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Fred Hutchinson Cancer Research Center patents (2016 archive)


Recent patent applications related to Fred Hutchinson Cancer Research Center. Fred Hutchinson Cancer Research Center is listed as an Agent/Assignee. Note: Fred Hutchinson Cancer Research Center may have other listings under different names/spellings. We're not affiliated with Fred Hutchinson Cancer Research Center, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "F" | Fred Hutchinson Cancer Research Center-related inventors


Methods, systems, apparatus and software for use in acceptance and commitment therapy

Various embodiments of the present disclosure comprise methods, apparatus, systems and software for use in implementing acceptance and commitment therapy (act). The methods include notifying or reminding users to track completion of exercises, and to track and/or monitor awareness of urges and the number of times the user allows urges to pass. ... Fred Hutchinson Cancer Research Center

Liquid chalcogenide compositions and methods of manufacturing and using the same

The present invention provides novel stable, liquid compositions comprising chalcogenides or salts thereof. These compositions may be used for a variety of purposes, including the treatment and prevention of ischemic or hypoxic injury, as well as in the preservation of biological matter.. ... Fred Hutchinson Cancer Research Center

Methods, compositions and articles of manufacture for enhancing survivability of cells, tissues, organs, and organisms

The present invention concerns the use of oxygen antagonists and other active compounds for inducing stasis or pre-stasis in cells, tissues, and/or organs in vivo or in an organism overall, in addition to enhancing their survivability. It includes compositions, methods, articles of manufacture and apparatuses for enhancing survivability and for achieving stasis or pre-stasis in any of these biological materials, so as to preserve and/or protect them. ... Fred Hutchinson Cancer Research Center

Halogen treatment of heart attack and ischemic injury

The present invention relates to the use of halogen compounds, including iodide, and chalcogenide compounds, including iodide, sulfide and selenide, to treat and prevent diseases and injuries. The present invention further relates to compositions comprising a halogen compound and/or a chalcogenide compound, including pharmaceutical compositions, as well as methods of manufacturing such compounds and administering such compositions to subjects in need thereof.. ... Fred Hutchinson Cancer Research Center

Compositions and methods for accurately identifying mutations

The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.. . ... Fred Hutchinson Cancer Research Center

Compounds and methods for preventing, treating and/or protecting against sensory hair cell death

Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing, treating, and/or protecting against sensory hair cell death. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.. ... Fred Hutchinson Cancer Research Center

Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set

Compositions and methods are disclosed for uniquely tagging each rearranged gene segment that encodes a t cell receptor (tcr) and/or an immunoglobulin (ig), in a dna (or mrna or cdna reverse transcribed therefrom) sample from lymphoid cells. These and related embodiments permit accurate, high throughput quantification of distinct tcr and/or ig encoding sequences. ... Fred Hutchinson Cancer Research Center

Enhanced generation of cytotoxic t lymphocytes by il-21 mediated foxp3 suppression

A method of carrying out adoptive immunotherapy by administering a subject an antigen-specific cytotoxic t lymphocytes (ctl) preparation in a treatment-effective amount is described. In the method, the ctl preparation is preferably administered as a preparation of an in vitro antigen-stimulated and expanded primate ctl population, the ctl population: (i) depleted of foxp3+ t lymphocytes prior to antigen stimulation; (ii) antigen-stimulated in vitro in the presence of interleukin-21; or (iii) both depleted of foxp3+ t lymphocytes prior to antigen stimulation and then antigen-stimulated in vitro in the presence of interleukin-21. ... Fred Hutchinson Cancer Research Center

Methods for identifying therapeutic targets and treating monitoring cancers

The present invention provides methods for treating cancers having a mutation in one or more tumor suppressor genes, comprising providing to a subject in need thereof an inhibitor of a kinase, as well as related methods and compositions.. . ... Fred Hutchinson Cancer Research Center

Methods for treating hematological malignancies

Described herein are methods for treating hematological malignancies and/or solid tumors in a subject using inhibitors of integrin alpha 6. In some embodiments, the inhibitors are monoclonal antibodies. ... Fred Hutchinson Cancer Research Center

Engineered high-affinity human t cell receptors

T cell receptors (tcrs) that have specificity for the wt1 antigen are provided. The tcrs include higher affinity tcrs that were engineered through the generation of mutational libraries of tcrs in a single-chain format, followed by selection for improved stability and affinity on the surface of yeast (i.e. ... Fred Hutchinson Cancer Research Center

Method of measuring adaptive immunity

The present disclosure provides compositions, kits, and methods to protect organs by inducing acquired cytoresistance without causing injury to the organ. The compositions, kits, and methods utilize heme proteins, iron and/or vitamin b12 and, optionally, agents that impact heme protein metabolism.. A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. ... Fred Hutchinson Cancer Research Center

Cocal vesiculovirus envelope pseudotyped retroviral vectors

Provided herein are cocal vesiculovirus envelope pseudotyped retroviral vectors that exhibit high titers, broad species and cell-type tropism, and improved serum stability. Disclosed cocal vesiculovirus envelope pseudotyped retroviral vectors may be suitably employed for gene therapy applications and, in particular, for the ex vivo and in vivo delivery of a gene of interest to a wide variety of target cells.. ... Fred Hutchinson Cancer Research Center

Compositions and methods for directed immunogen evolution and uses thereof

The present disclosure relates to compositions and methods for using a modified virus that infects a cell only if the virus presents a candidate antigen that binds with high affinity to a target antibody, thereby allowing for generation and identification of immunogens useful, for example, as vaccines.. . ... Fred Hutchinson Cancer Research Center

07/14/16 / #20160199418

Compositions and methods for providing hematopoietic function

The present invention relates to methods and compositions for providing hematopoietic function to human patients in need thereof, by selecting a pool of expanded human cord blood stem/progenitor cell samples for administration to the patient, wherein the samples in the pool collectively do not mismatch the patient at more than 2 of the hla antigens or alleles typed in the patient; and administering the selected pool of expanded human cord blood stem/progenitor cell samples to the patient. Methods for obtaining the pools of expanded human cord blood stem/progenitor cell samples, banks of frozen pools of expanded human umbilical cord blood stem/progenitor cell samples, and methods for producing such banks are also provided herein.. ... Fred Hutchinson Cancer Research Center

07/07/16 / #20160194664

Compositions and methods for generating adeno-associated viral vectors with undetectable capsid gene contamination

In one aspect, the present invention provides an intron-modified capsid expression cassette useful for generating adeno-associated virus (aav) vector particles. In another aspect, the present invention provides a method of reducing the immune response in a mammalian subject undergoing treatment with an aav vector.. ... Fred Hutchinson Cancer Research Center

07/07/16 / #20160193369

Magnetic nanoparticle and method for imaging t cells

The present invention provides nanoparticles having a core comprising a magnetic material and having a surface, where the surface may be operatively linked to an antigenic peptide-major histocompatibility complex (mhc) monomer. The antigenic peptide-mhc monomer may then be recognized by a t cell receptor. ... Fred Hutchinson Cancer Research Center

05/26/16 / #20160145603

Compositions for making random codon-mutant libraries and uses thereof

The present disclosure relates to compositions and methods for randomly introducing codon-mutations in a target nucleic acid molecule and, more particularly, using wild-type and triplet-randomized oligonucleotides to introduce mutations uniformly across a target nucleotide of interest in a controlled fashion and with a low rate of insertions or deletions.. . ... Fred Hutchinson Cancer Research Center

05/26/16 / #20160145348

Compositions and methods to modify cells for therapeutic objectives

The present disclosure provides compositions and methods that rapidly and selectively modify cells of the immune system to achieve therapeutic objectives. The methods can be practiced in vivo and any cell type that expresses a known marker can be targeted for a therapeutic objective. ... Fred Hutchinson Cancer Research Center

05/12/16 / #20160129093

Compositions, methods and uses for alpha-1 antitrypsin or derivatives thereof

Embodiments herein report methods and compositions for treating or preventing adverse effects of radiation therapies. In certain embodiments, compositions and methods relate to reducing or inhibiting damage due to acute, periodic or chronic radiation exposure.. ... Fred Hutchinson Cancer Research Center

04/07/16 / #20160095883

Method for the treatment of obesity

The present invention relates to therapeutic compositions for treating or preventing obesity and obesity-related disorders in a subject using immunotherapy to target and eliminate adipocytes.. . ... Fred Hutchinson Cancer Research Center

03/24/16 / #20160083699

High efficiency flp site-specific recombination in mammalian cells using an optimized flp gene

The present invention provides an optimized flp site-specific recombinase coding sequence and methods for its use. This genetically engineered flp gene displays a marked increase in recombination efficiency compared to the native flp gene and is therefore useful in a wide array of molecular applications.. ... Fred Hutchinson Cancer Research Center

03/24/16 / #20160083449

T cell immunotherapy specific for wt-1

The present disclosure provides high affinity and enhanced affinity t cell receptors specific for human wilms tumor protein 1 (wt-1) epitopes for use in treating diseases or disorders, such as cancer cells that overexpress wt-1.. . ... Fred Hutchinson Cancer Research Center

02/18/16 / #20160045594

Directed immune stimulation

A synthetic polypeptide vaccine is employed for directed targeting of an individual's immune response to an antigen of interest. The synthetic polypeptide contains a carrier epitope specific for open conformers of an individual's mhc-i molecules in the presence of hla-f, and also contains an effector epitope which elicits an immune response to the antigen of interest. ... Fred Hutchinson Cancer Research Center

02/18/16 / #20160045580

Identification of cd8+ t cells that are cd161hi and/or il18r(alpha)hi and have rapid drug efflux capacity

This invention provides, among other things, methods for the identification and isolation of viable putative long-lived antigen-specific memory cd8+ t cell subsets (cmhi and emhi) with high surface expression of cd161 and/or il-18rα and the capacity to rapidly efflux the fluorescent dye rh123.. . ... Fred Hutchinson Cancer Research Center

01/21/16 / #20160015701

Methods of treating acute kidney injury

Methods are provided for treating acute kidney injury in a subject, particularly ischemia-induced kidney injury and/or hypoxia-induced kidney injury. The methods comprise administering to the subject an eta receptor antagonist, such as atrasentan or a pharmaceutically acceptable salt thereof. ... Fred Hutchinson Cancer Research Center

01/14/16 / #20160008399

Compositions and methods for delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse

The present disclosure provides compositions and methods for the delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse. The compositions comprise (i) a structure comprising an injectable polymer or scaffold comprising pores; (ii) lymphocytes disposed within the structure, (iii) at least one lymphocyte-adhesion moiety associated with the structure; and (iv) at least one lymphocyte-activating moiety associated with the structure, and optionally an immune stimulant.. ... Fred Hutchinson Cancer Research Center








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