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Fred Hutchinson Cancer Research Center patents (2017 archive)


Recent patent applications related to Fred Hutchinson Cancer Research Center. Fred Hutchinson Cancer Research Center is listed as an Agent/Assignee. Note: Fred Hutchinson Cancer Research Center may have other listings under different names/spellings. We're not affiliated with Fred Hutchinson Cancer Research Center, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "F" | Fred Hutchinson Cancer Research Center-related inventors


Characterization of adaptive immune response to vaccination or infection using immunosequencing

Methods of monitoring and measuring dynamic adaptive immune cell responses are provided. High-throughput sequencing of t cell receptor and immunoglobulin loci is used to characterize the breadth of an effector cell response to a stimulus, such as a vaccine or infection. ... Fred Hutchinson Cancer Research Center

Enhanced affinity t cell receptors and methods for making the same

The present disclosure provides methods for generating enhanced affinity t cell receptors by agonist selection of hematopoietic progenitor cells expressing an antigen specific tcrα cultured with stromal cells expressing delta-like-1 or delta-like-4, compositions prepared from such methods, and uses of thereof.. . ... Fred Hutchinson Cancer Research Center

Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from a large number of samples

The invention is directed to methods for highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune heterodimers from a large number of biological samples containing lymphocytes of interest. Methods of the invention comprise performing a single pairing assay on a pool of source samples to determine nucleic acids encoding paired cognate receptor heterodimer chains in the combined pool. ... Fred Hutchinson Cancer Research Center

Method of measuring adaptive immunity

Compositions and methods for measuring adaptive immune receptor (t cell receptor and immunoglobulin) diversity are described, and find uses for assessing immunocompetence and other purposes. Means are provided for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. ... Fred Hutchinson Cancer Research Center

Pancreatic cancer diagnostic

The present disclosure provides methods of using certain biomarker expression profiles in the detection, diagnosis, prognosis, or development of treatment regimens for various cellular hyperproliferative disorders of the pancreas. For example, methods comprise detecting whether the concentration of erbb2, esr1, and tnc in a test biological sample from a subject is elevated as compared to a control.. ... Fred Hutchinson Cancer Research Center

Tagged chimeric effector molecules and receptors thereof

The present disclosure relates to tagged chimeric effector molecules and receptor molecules thereof for genetically engineering a host cell, wherein the recombinant host cell can be identified, isolated, sorted, induced to proliferate, tracked or eliminated using the tag. An exemplary receptor molecule is a chimeric antigen receptors (cars) having an extracellular domain comprising a binding domain for a target, a hinge region and a tag cassette, a hydrophobic portion as a transmembrane domain and, an intracellular part with an effector domain. ... Fred Hutchinson Cancer Research Center

Cell population analysis using single nucleotide polymorphisms from single cell transcriptomes

The disclosure provides methods and systems for producing single cell rna sequencing data. Single nucleotide polymorphisms (snps) identified in such data can be used to distinguish subpopulations of cells within a mixed population.. ... Fred Hutchinson Cancer Research Center

Compositions and methods for boosting the efficacy of adoptive cellular immunotherapy

The present disclosure provides compositions and methods for boosting, augmenting or enhancing the efficacy of the adoptive cellular immunotherapy by using modified t cells expressing an antigen binding protein in conjunction with modified cells (such as hematopoietic progenitor cells, modified human immune system cells or a combination thereof) expressing the antigen specifically bound by the antigen binding protein of the modified t cells.. . ... Fred Hutchinson Cancer Research Center

Compositions, kits, and methods to induce acquired cytoresistance using stress protein inducers

The present disclosure provides compositions, kits, and methods to protect organs by inducing acquired cytoresistance without causing injury to the organ. The compositions, kits, and methods utilize heme proteins, iron and/or vitamin b12 and, optionally, agents that impact heme protein metabolism.. ... Fred Hutchinson Cancer Research Center

Expansion and engraftment of stem cells using notch 1 and/or notch 2 agonists

The present disclosure provides methods for immortalizing precursor cells that are non-terminally differentiated cells such as stem cells, the methods comprising culturing the precursor cells in the presence of a notch 1 agonist, notch 2 agonist or notch 1 agonist and notch 2 agonist (and, in particular embodiments, one or more growth factors) that support the proliferation but not differentiation of the non-terminally differentiated cells. The present disclosure further provides methods to induce the differentiation of immortalized cells, comprising growing the cells in the presence of a notch 1 agonist, notch 2 agonist or notch 1 agonist and notch 2 agonist and at least one growth factor which supports the differentiation of the cell into a more specialized cell type. ... Fred Hutchinson Cancer Research Center

Compositions and methods to modulate angiogenesis

The present invention provides methods of stimulating angiogenesis and the growth or migration of cells associated with angiogenesis, by contacting animals, tissues, or cells with sulfide, alone or in combination with nitric oxide. These methods may be used for a variety or purposes, including promoting wound healings, increasing blood flow, and for the treatment and prevention of diseases and disorders associated with decreased blood flow, including ischemic or hypoxic injury.. ... Fred Hutchinson Cancer Research Center








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