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Geno Llc patents


Recent patent applications related to Geno Llc. Geno Llc is listed as an Agent/Assignee. Note: Geno Llc may have other listings under different names/spellings. We're not affiliated with Geno Llc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "G" | Geno Llc-related inventors


Methods and systems for processing polynucleotides

The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.. ... Geno Llc

Phasing analysis with dynamic programming algorithm

Provided herein are methods and systems useful for the determination and assignment of haplotypes for genetic loci.. . ... Geno Llc

Linkage disequilibrium method and database

A method for determining the association of human leukocyte antigen (hla) alleles at adjacent loci in genomic dna from a biological sample obtained from a human subject is disclosed. A method and system of validating correctness of an assignment of an allele variant to a genetic human leucocyte antigen (hla) locus are also disclosed.. ... Geno Llc

Analysis of nucleic acid sequences

The present disclosure relates to methods, compositions and systems for haplotype phasing and copy number variation assays. Included within this disclosure are methods and systems for combining the barcode comprising beads with samples in multiple separate partitions, as well as methods of processing, sequencing and analyzing barcoded samples.. ... Geno Llc

Data security in bioinformatic sequence analysis

Systems and methods for protecting information stored in private references that are available to be queried—e.g., graph-based sequence references that users query through an interface, providing short reads to obtain the results of an alignment against the reference sequence—analyze the query and/or alignment results to determine whether the query represents an attack. The analysis may be performed before returning results to a user, and in some cases before performing the alignment.. ... Geno Llc

Watermarking for data security in bioinformatic sequence analysis

Embodiments of the invention protect information stored in graph-based sequence references by “watermarking” the graph with uniquely identifiable information. The watermark identifies the graph or version thereof in a detectable but nonintrusive manner. ... Geno Llc

Methods and compositions for identifying or quantifying targets in a biological sample

Compositions, kits and methods are described that comprise one or more constructs, each construct comprising a ligand attached or conjugated to a polymer construct, e.g., an oligonucleotide sequence, by a linker, each ligand binding specifically to a single target located in or on the surface of a cell. The polymer construct comprises a) an amplification handle; b) a barcode that specifically identifies a single ligand; c) an optional unique molecular identifier that is positioned adjacent to the barcode on its 5′ or 3′ end; and d) an anchor for hybridizing to a complementary sequence, e.g., for generation of a double-stranded oligonucleotide. ... Geno Llc

Expression of modified glycoproteins and glycopeptides

The present invention provides recombinant cells that contain a genetic modification to at least one mannosyl transferase gene. As a result of the modification the cells produce a glycoprotein or glycopeptide that has an n-linked glycan profile that is simplified or more easily humanized. ... Geno Llc

Single-molecule image correction method, device and system, and computer-readable storage medium

An embodiment of the present disclosure discloses a method and a device of correcting a single-molecule image, the method includes: acquiring the first target simplified matrix corresponding to the first image according to the intensity matrix corresponding to each of pixels in the first image, and acquiring the second target simplified matrix corresponding to the second image according to the intensity matrix corresponding to each of the pixels in the second image; the two-dimensional dft is performed to the first target simplified matrix and the second target simplified matrix respectively to acquire the first fourier matrix corresponding to the first target simplified matrix and the second fourier matrix corresponding to the second target simplified matrix; the method of correcting a single-molecule image acquire the offset of the second image with respect to the first image according to the first fourier matrix and the second fourier matrix; and correcting the second image according to the offset. Such method can correct the images of single molecules taken at different moments.. ... Geno Llc

Bioinformatics systems, apparatuses, and methods executed on a quantum processing platform

A system, method and apparatus for executing a bioinformatics analysis on genetic sequence data includes a quantum computing device formed of a set of hardwired quantum logic circuits interconnected by a plurality of superconducting connections to process information represented as a quantum state that is configured as a set of one or more qubits. The hardwired quantum logic circuits may be arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired quantum logic circuits to perform one or more steps in the bioinformatics analysis on the reads of genomic data. ... Geno Llc

Bioinformatics systems, apparatuses, and methods executed on an integrated circuit processing platform

A system, method and apparatus for executing a sequence analysis pipeline on genetic sequence data includes a structured asic formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the structured asic connected with an electronic data source for receiving reads of genomic data. ... Geno Llc

Compositions and multiplexed systems for coupled cell-free transcription-translation and protein synthesis and methods for using them

In alternative embodiments, provided herein are transcription/translation (tx-tl) systems and methods of using them for use as rapid prototyping platforms for the synthesis, modification and identification of natural products (nps), and natural product analogs (npas) and secondary metabolites, from biosynthetic gene cluster pipelines. In alternative embodiments, exemplary tx-tl systems as provided herein are used for the combinatorial biosynthesis of natural products (nps), natural product analogs (npas) and secondary metabolites. ... Geno Llc

Process and systems for obtaining 1,4-butanediol from fermentation broths

A process of purifying 1,4-butanediol (1,4-bdo) from a fermentation broth including separating solid materials, salts and water, and subjecting the resulting material to a two, three or four column distillation system, that can include a wiped film evaporator to produce a purified 1,4-butanediol product.. . ... Geno Llc

Instrument systems for integrated sample processing

An integrated system for processing and preparing samples for analysis may include a microfluidic device including a plurality of parallel channel networks for partitioning the samples including various fluids, and connected to a plurality of inlet and outlet reservoirs, at least a portion of the fluids comprising reagents, a holder including a closeable lid hingedly coupled thereto, in which in a closed configuration, the lid secures the microfluidic device in the holder, and in an open configuration, the lid is a stand orienting the microfluidic device at a desired angle to facilitate recovery of partitions or droplets from the partitioned samples generated within the microfluidic device, and an instrument configured to receive the holder and apply a pressure differential between the plurality of inlet and outlet reservoirs to drive fluid movement within the channel networks.. . ... Geno Llc

08/23/18 / #20180235737

Drilling driver for placing dental implant

The present disclosure provides a drilling driver for placing a dental implant. The drilling driver includes: a tip part having a first outer diameter and having a cutting edge; a small-diameter part extended from the tip part, and having a second outer diameter smaller than the first outer diameter; and a large-diameter part positioned farther from the tip part than the small-diameter part, and having a third outer diameter larger than the first outer diameter.. ... Geno Llc

08/16/18 / #20180233230

Systems and methods for predicting treatment-regimen-related outcomes

Systems and methods are provided for predicting treatment-regimen-related outcomes (e.g., risks of regimen-related toxicities). A predictive model is determined for predicting treatment-regimen-related outcomes and applied to a plurality of datasets. ... Geno Llc

08/16/18 / #20180232483

Systems and methods for analyzing sequence data

The invention provides methods for comparing one set of genetic sequences to another without discarding any information within either set. A set of genetic sequences is represented using a directed acyclic graph (dag) avoiding any unwarranted reduction to a linear data structure. ... Geno Llc

08/16/18 / #20180230548

Gene expression markers for breast cancer prognosis

The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.. . ... Geno Llc

08/16/18 / #20180230480

Method for plant improvement

The invention relates to the field of plant improvement, in particular of the improvement of yield for plants, by using a transgene containing an root-specific promoter driving expression of a myb-related protein.. . ... Geno Llc

08/09/18 / #20180226153

Systems and methods for predicting treatment-regimen-related outcomes

Systems and methods are provided for predicting treatment-regimen-related outcomes (e.g., risks of regimen-related toxicities). A predictive model is determined for predicting treatment-regimen-related outcomes and applied to a plurality of datasets. ... Geno Llc

08/09/18 / #20180225416

Systems and methods for visualizing a pattern in a dataset

A visualization system comprising a persistent memory, storing a dataset, and a non-persistent memory implements a pattern visualizing method. The dataset contains discrete attribute values for each first entity in a plurality of first entities for each second entity in a plurality of second entities. ... Geno Llc

08/09/18 / #20180223361

Characterization of molecules in nanofluidics

Methods are provided for detecting and quantitating molecules using fluidics. In preferred embodiments, the methods comprise analyzing blood to detect the presence of circulating dna or cells from a fetus or tumor.. ... Geno Llc

08/09/18 / #20180223342

Systems and methods for nucleic acid preparation

The present disclosure provides methods and systems for nucleic acid processing. A method for preparing a sequencing set may include providing a template nucleic acid and amplifying the template nucleic acid to provide a complementary nucleic acid. ... Geno Llc

08/09/18 / #20180221109

Multi-drilling guide device for implantation

The present disclosure relates to a multi drilling guide device for operating an implant. By way of example, the multi drilling guide device includes: a rod extending in a longitudinal direction; a fixing portion combined with one end of the rod and having a drill hole penetrating therethrough; and a guide portion coupled to the rod so as to be movable and rotatable along the rod and having a guide hole.. ... Geno Llc

08/02/18 / #20180218789

Methods and systems for sequencing-based variant detection

Provided herein are methods and systems for detecting genetic variants from sequencing data. The methods and systems provided herein can be useful for identifying the presence or absence of clinically actionable variants from a sequencing data set and reporting the clinically actionable variants to a user of the methods and systems.. ... Geno Llc

08/02/18 / #20180216197

Molecular subtyping, prognosis, and treatment of bladder cancer

The present invention relates to methods, systems and kits for the diagnosis, prognosis, and treatment of bladder cancer in a subject. The invention also provides biomarkers that define subgroups of bladder cancer, clinically useful classifiers for distinguishing bladder cancer subtypes, bioinformatic methods for determining clinically useful classifiers, and methods of use of each of the foregoing. ... Geno Llc

08/02/18 / #20180216162

Methods and systems for droplet-based single cell barcoding

Methods and systems are provided for sample preparation techniques and sequencing of macromolecular constituents of cells and other biological materials.. . ... Geno Llc

07/26/18 / #20180208968

Methods for depleting rna from nucleic acid samples

The invention relates to methods of depleting rna from a nucleic acid sample. The rna may be any rna, including, but not limited to, rrna, trna, and mrna. ... Geno Llc

07/26/18 / #20180208933

Bacteria with improved metabolic capacity

E. Coli bacteria comprising genetic modifications to enhance fermentability and production of protein and nucleic acids are provided.. ... Geno Llc

07/19/18 / #20180201941

Regulatory elements from labyrinthulomycetes microorganisms

The present disclosure generally relates to novel polynucleotide molecules for use in regulating gene expression in recombinant cells, such as labyrinthulomycetes cells. The disclosure further relates to nucleic acid constructs, such as vectors and expression cassettes, containing a regulatory element operably linked to a heterologous nucleotide sequence. ... Geno Llc

07/19/18 / #20180201914

Novel alpha-1,3-glucanase

The present invention relates to a novel alpha-1,3-glucanase, and more particularly, to a novel alpha-1,3-glucanase from trichoderma harzianum, a gene encoding the same, a recombinant vector and recombinant microorganism comprising the gene, and a method of producing an alpha-1,3-glucanase using the recombinant microorganism. The novel alpha-1,3-glucanase according to the present invention can effectively degrade mutan, which is a component of a microbial biofilm, and thus it can be used in oral hygiene products and the medical field.. ... Geno Llc

07/19/18 / #20180201904

In vitro production of expanded potential stem cells

A culture medium is provided which is capable of establishing expanded potential stem cell (epsc) lines which resemble naive or ground state es cells, but are also able to differentiate into placenta trophoblasts and the embryo proper. Methods are provided using the medium for the in vitro conversion and maintenance of cells, including pluripotent cells into epscs.. ... Geno Llc

07/19/18 / #20180199826

System and method of assessing endothelial function

A medical diagnostic system and method for assessing endothelial function comprise adjusting a reactive hyperemia indicator, measured in response to a stimulus, based on an anthropomorphic and/or demographic variable. The adjusted reactive hyperemia indicator provides a more accurate reflection of endothelial function and can be communicated to a clinician.. ... Geno Llc

07/12/18 / #20180196917

Bioinformatics systems, apparatuses, and methods executed on an integrated circuit processing platform

A system, method and apparatus for executing a sequence analysis pipeline on genetic sequence data includes a structured asic formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the structured asic connected with an electronic data source for receiving reads of genomic data. ... Geno Llc

07/12/18 / #20180196916

Bioinformatics systems, apparatuses, and methods for performing secondary and/or tertiary processing

A system, method and apparatus for executing a bioinformatics analysis on genetic sequence data is provided. Particularly, a genomics analysis platform for executing a sequence analysis pipeline is provided. ... Geno Llc

07/12/18 / #20180196781

Methods and apparatus for sorting data

A computer implemented system for genomic data sorting, comprising alignment and position mapping. The system maps each read to a position on the reference genome with which the read is associated, followed by sorting these reads by their mapped positions.. ... Geno Llc

07/12/18 / #20180195117

Sequencing method, apparatus, system and application thereof

A sequencing method comprising: (i) combining a template nucleic acid having a first optical detection label at the end with a primer to obtain a first complex; (ii) imaging the first complex to obtain a first image; (iii) mixing the first complex, polymerase, and one or more of nucleotides with a optical detection label to obtain an extension product by polymerization reaction; (iv) imaging the extension product to obtain a second image; (v) removing the cleavable group of the nucleotides with the optical detection label from the extension product to obtain a second complex; (vi) repeating the above steps (ii) to (v) once or more times to determine the template nucleic acid sequence. The sequencing method can achieve single molecule sequencing by capturing template nucleic acids through primers.. ... Geno Llc

07/12/18 / #20180195083

Improvement of plant yield

The invention relates to a method for improving the yield of a plant, comprising overexpressing in said plant a glutamine synthetase, said glutamine synthetase being both constitutively overexpressed in said plant and specifically overexpressed in the bundle sheath cells of said plant. The invention also relates to means for obtaining plants with improved yield.. ... Geno Llc

07/12/18 / #20180195076

Microorganisms for the production of aniline

A non-naturally occurring microbial organism having an aniline pathway includes at least one exogenous nucleic acid encoding an aniline pathway enzyme expressed in a sufficient amount to produce aniline. The aniline pathway includes (1) an aminodeoxychorismate synthase, an aminodeoxychorismate lyase, and a 4-aminobenzoate carboxylyase or (2) an anthranilate synthase and an anthranilate decarboxylase. ... Geno Llc

07/12/18 / #20180193440

Immunogenic compositions and expression systems

Immunogenic compositions and vaccines against plasmodial infection comprising an rh polypeptide or a fragment or variant thereof are disclosed. Also disclosed are rh5 polypeptides or fragments or variants thereof capable of binding cd147 and conferring protection against infection and/or disease caused by multiple plasmodial strains or plasmodial species, inhibitors of the interaction between rh5 and cd147 and methods for producing polypeptides in a mammalian expression system.. ... Geno Llc

07/12/18 / #20180193403

Healthful supplements

Healthful supplements are described herein. For example, the supplements can include at least four of the following types of nutrients: an amino acid blend, a coconut extract, a vegetable glycerin extract, an alcohol blend, a cannabinoid blend, a hemp plant extract, a boswellia serrata extract, a curcuma/turmeric blend, black cumin seed, an artemisia ludoviciana extract, an astragalus extract, a fenugreek extract, a mushroom extract blend, or any combination thereof.. ... Geno Llc

07/05/18 / #20180191425

High speed phase shift keying modulator

Provided is a high speed phase shift keying modulator. The high speed phase shift keying modulator has variable pipeline buffers formed at an input side and an output side of a bandlimiting filter and a compensation filter to ensure timing margins of the bandlimiting filter and the compensation filter, so that a ultra-high speed phase shift keying modulator is provided.. ... Geno Llc

07/05/18 / #20180189444

Bioinformatics systems, apparatuses, and methods for generating a de bruijn graph

A system, method and apparatus for executing a bioinformatics analysis on genetic sequence data is provided. Particularly, a genomics analysis platform for executing a sequence analysis pipeline is provided. ... Geno Llc

07/05/18 / #20180187260

Systems and methods for obtaining biological molecules from a sample

The present invention relates to a method of creating a biomarker profile, the method comprising the steps of: obtaining a sample of biofluid from a subject, wherein the sample is stored on a sample collection apparatus; removing the sample from the sample collection apparatus; extracting nucleic acids from the sample; sequencing the extracted nucleic acids to generate sequence data; and analyzing the sequence data using a two-step analytical methodology to create the biomarker profile. The present invention athletic performance in a subject.. ... Geno Llc

07/05/18 / #20180187256

Method for controlling base sequence determination, base sequence determination system and control device

The present disclosure discloses a method for controlling a base sequence determination, a base sequence determination system, and a control device. The base sequence determination system includes a fluid device and an optical device, a reaction device includes a first component and a second component, and a repeated executable unit included in the base sequence determination is defined as: a second biochemical reaction—a first biochemical reaction—photographing. ... Geno Llc

07/05/18 / #20180187250

Method of detecting genetic material in a biological sample and a device for its implementation

The object of the invention is a method of detecting genetic material in a biological sample in which the biological sample is loaded into the reaction cartridge (6) and then the reaction cartridge (6) is placed in the control device, the collected biological sample is taken to the isolation chamber (7), isolation of biological material from the tested sample by heating the isolation chamber (7), the isolated genetic material is moved into a plurality of reaction chambers (8.1, 8.2, 8.3, 8.4), genetic material is amplified by heating the reaction chambers (8.1, 8.2, 8.3, 8.4), lyophilized reagents for genetic material amplification together with lyophilized fluorescent tag intercalating with genetic material are present in the reaction chambers (8.1, 8.2, 8.3, 8.4), and signal detection from fluorescent tags is carried out along with the genetic material amplification stage.. . ... Geno Llc

07/05/18 / #20180187241

Accurate molecular deconvolution of mixture samples

The present disclosure relates to methods to deconvolute a mixture sample of genetic material from different origins or sources. The disclosed methods can be used in various applications, including, the non-invasive determination of a fetal genome, a fetal -ome (e.g. ... Geno Llc

07/05/18 / #20180186842

High productivity algal mutants having reduced photosynthetic antenna

Disclosed herein are mutant photosynthetic microorgnaisms having an attenuated sgi1 gene. The mutants have reduced chlorophyll and increased productivity with respect to wild type cells. ... Geno Llc

07/05/18 / #20180185371

Systems and methods for treating cancer

Embodiments of the invention provide a method of treating cancer, the method comprising providing a subject having cancer cells, and contacting the cancer cells with a therapeutically effective amount of a g2/m checkpoint inhibitor. Embodiments of the invention also provide a method of treating cancer in a subject, the method comprising the steps of: (a) receiving a sample of the cancer cells from the subject; (b) determining if at least a portion of the sample of the cancer cells is lkb 1 deficient; and (c) contacting the cancer cells with a therapeutically effective amount of a g2/m checkpoint inhibitor.. ... Geno Llc

06/28/18 / #20180182602

A phototube and method of making it

A phototube suitable for detecting a photon, comprising: an electron ejector configured for emitting electrons in response to an incident photon; a detector configured for collecting the electrons and providing an output signal representative of the incident photon; an electrode configured for applying a voltage to drive the electrons to the detector; and one or more sidewalls forming an envelope of a hole between the electrode and the detector, wherein the electron ejector is inside the hole and bonded to the electrode.. . ... Geno Llc

06/28/18 / #20180182479

Weight management genetic test systems and methods

Disclosed herein is a nutritional genomic weight management algorithm running on a computer system, and more specifically, a nutritional genomic weight management algorithm where an analysis of a customer's unique dna results in individualized diet and exercise plans, in accordance with the present invention. Methods of weight management, weight management business methods, and panels of alleles for nutritional genomics are also disclosed.. ... Geno Llc

06/28/18 / #20180181708

Bioinformatics systems, apparatuses, and methods executed on an integrated circuit processing platform

A system, method and apparatus for executing a bioinformatics analysis on genetic sequence data includes an integrated circuit formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the integrated circuit that may be connected with an electronic data source for receiving reads of genomic data. ... Geno Llc

06/28/18 / #20180180547

A biosensor

Disclosed herein is an apparatus comprising: a probe carrier comprising: a substrate comprising with holes through a thickness of the substrate and a transparent window across an opening of each of the holes, wherein the transparent window closes the opening, wherein one or more locations on the transparent window are configured to have probes attached thereto, wherein interaction between the probes and an analyte generates a signal; an optical system comprising a plurality of collimators; a sensor configured to detect the signal; wherein the collimators can essentially prevent light from passing if a deviation of a propagation direction of the light from an optical axis of the collimators is greater than a threshold. Because the probe carrier is separate and independent from the microarray, the probe carrier may be assembled with a pre-existing microarray prior to its use, and be detached from the microarray and disposed after its use.. ... Geno Llc

06/28/18 / #20180179591

Methods and systems for processing polynucleotides

The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.. ... Geno Llc

06/28/18 / #20180179590

Methods and systems for processing polynucleotides

The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.. ... Geno Llc

06/28/18 / #20180179580

Compositions and methods for sample processing

This disclosure provides methods and compositions for sample processing, particularly for sequencing applications. Included within this disclosure are bead compositions, such as diverse libraries of beads attached to large numbers of oligonucleotides containing barcodes. ... Geno Llc

06/28/18 / #20180178221

Magnetic iron particles separating system

The present invention relates to a magnetic iron particle (mip) separating system for separating the magnetic beads existing in the mixed solution.. . ... Geno Llc

06/21/18 / #20180173848

Generation and use of simulated genomic data

Embodiments of the invention utilize a graph-based approach for simulating genomic datasets from large scale populations. Genomic data may be represented as a directed acyclic graph (dag) that incorporates individual sample data including variant type, position, and zygosity. ... Geno Llc

06/21/18 / #20180173648

Bioinformatics systems, apparatus, and methods executed on an integrated circuit processing platform

A system, method and apparatus for executing a sequence analysis pipeline on genetic sequence data includes an integrated circuit formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the integrated circuit connected with an electronic data source for receiving reads of genomic data. ... Geno Llc

06/21/18 / #20180171340

Compositions and methods for enhancing gene expression

The present disclosure generally relates to nucleic acid molecules for use in regulating gene expression. Disclosed herein include nucleic acid molecules containing one or more structural elements of the viral capsid enhancer operably linked to a coding sequence of a gene of interest. ... Geno Llc

06/14/18 / #20180165412

Neural network architectures for linking biological sequence variants based on molecular phenotype, and systems and methods therefor

We describe a system and a method that ascertains the strengths of links between pairs of biological sequence variants, by determining numerical link distances that measure the similarity of the molecular phenotypes of the variants. The link distances may be used to associate knowledge about labeled variants to other variants and to prioritize the other variants for subsequent analysis or interpretation. ... Geno Llc

06/14/18 / #20180165411

Systems and methods for assembling fragmented information

Computer systems obtain sets of entities. Each entity includes (i) a unique portion for a subset of a source entity and (ii) a common portion forming an identifier independent of the source and identifying a unit, in a plurality of units, that formed the entity. ... Geno Llc

06/14/18 / #20180165409

Method and device for identifying single molecule and method and device for counting single molecule

A method and a device for identifying a single molecule, a method and a device for counting a single molecule and a system for processing a single molecule are provided. The method for identifying the single molecule includes inputting time sequence of an intensity of an spot; forming a line chart of time and intensity of the spot according to the time sequence, wherein the line chart consists of a plurality of line segments; dividing the line chart into a plurality of grids in an array, counting the number of the line segments and/or ends of the line segments in each grid; subjecting the divided line chart to a line corrosion according to numbers corresponding to the grids to transform the divided line chart to a simplified image; subjecting the simplified image to run-length coding to indicate connected domains; calculating an area of each connected domain and determining that the connected domain corresponds to a single molecule if the area of the connected domain is greater than a first predetermined threshold. ... Geno Llc

06/14/18 / #20180163254

Methods for assembling dna molecules

The invention provides compositions and methods for assembling a dna molecule having a desired sequence. The methods involve contacting a dna polymerase, dntps, and a plurality of pairs of oligonucleotides. ... Geno Llc

06/07/18 / #20180157792

Systems and methods for aligning sequences to personalized references

Techniques for generating a personalized reference sequence construct for an individual to align sequence reads obtained for the individual. The techniques include: obtaining a plurality of sequence reads for an individual; obtaining information identifying a plurality of locations; genotyping the plurality of sequence reads for the plurality of locations to obtain a first set of variants for the individual for at least some of the plurality of locations; identifying a second set of variants associated with the first set of variants; generating a personalized reference sequence construct using the second set of variants; and aligning the plurality of sequence reads to the personalized reference sequence construct.. ... Geno Llc

06/07/18 / #20180155782

Biosensors for biological or chemical analysis and methods of manufacturing the same

Embodiments of the invention provide an improved biosensor for biological or chemical analysis. According to embodiments of the invention, backside illumination (bsi) complementary metal-oxide-semiconductor (cmos) image sensors can be used to effectively analyze and measure fluorescence or chemiluminescence of a sample. ... Geno Llc

06/07/18 / #20180155742

Microorganisms and methods for the biosynthesis of butadiene

The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene.. ... Geno Llc

06/07/18 / #20180155731

Nannochloropsis spliced leader sequences and methods of use thereof

The present invention relates to the culture and manipulation of microorganisms for biotech applications, and is based on the discovery and characterization of spliced leader sequences identified in transcripts from nannochloropsis species. In particular, the invention provides nucleic acid compositions comprising a sl sequence operably linked to a protein-encoding gene. ... Geno Llc

06/07/18 / #20180155699

Beta-galactosidase variant having high transglycosylation activity, and use thereof

The present invention relates to a beta-galactosidase mutant having high transglycosylation activity and containing a c-terminal deletion, and the use thereof and more. More specifically, the present invention relates to a beta-galactosidase mutant having a c-terminal deletion, a gene encoding the same, a recombinant vector containing the gene, a recombinant microorganism transformed with the gene or the recombinant vector, and a method for producing the beta-galactosidase mutant using the recombinant microorganism. ... Geno Llc

05/31/18 / #20180150597

Method for optimal design of polynucleotides sequences for analysis of specific events in any genetic region of interest

Methods including in-silico steps for design and synthesis of genomic morse code (“gmc”) probes including design of combinations of polynucleotide sequences and labelling colors for analysis of large rearrangements in targeted genetic regions as well as allele characterization of complex regions and localization of events such as replication, dna reparation or epigenetics in particular regions. Color-encoded sets of probes that produce characteristic or unique color patterns when painted on a target nucleic acid sequence. ... Geno Llc

05/31/18 / #20180148717

Methods for generating circular dna from circular rna

Provided herein are methods of amplifying nucleic acids. In particular, methods are provided for amplifying circular rna molecules. ... Geno Llc

05/24/18 / #20180143914

Method and system for genomic visualization

A method and system for correlating genome data with emr/mr data is disclosed herein. The method includes identifying a plurality of sources of genome data. ... Geno Llc

05/24/18 / #20180142292

Methods and systems for processing polynucleotides

The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.. ... Geno Llc

05/24/18 / #20180142269

Microorganisms for the production of 1,4-butanediol

The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (bdo) pathway comprising at least one exogenous nucleic acid encoding a bdo pathway enzyme expressed in a sufficient amount to produce bdo. The invention additionally provides methods of using such microbial organisms to produce bdo.. ... Geno Llc

05/24/18 / #20180142212

Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells

The present invention relates to methods, kits and compositions for expansion of hematopoietic stem/progenitor cells and providing hematopoietic function to human patients in need thereof. In one aspect, it relates to kits and compositions comprising a notch agonist and an aryl hydrocarbon receptor antagonist. ... Geno Llc

05/17/18 / #20180137387

Systems and methods for aligning sequences to graph references

Various embodiments of the disclosure relate to systems and methods for aligning a sequence read to a graph reference. In one embodiment, the method comprises selecting a first node from a graph reference, the graph reference comprising a plurality of nodes connected by a plurality of directed edges, at least one node of the plurality of nodes having a nucleotide sequence. ... Geno Llc

05/17/18 / #20180137255

System and method for characterizing data through a probabilistic data structure

A system and method for resolving data through a probabilistic data structure can include initializing a b-field data structure, inserting a key-value element into the b-field data structure, selecting at least one key query, and looking up the value of a key lookup request through the b-field data structure.. . ... Geno Llc

05/17/18 / #20180135119

Nucleic acid sequencing system

A nucleic acid sequencing system is provided, including a base provided with a clamping platform, a reagent storage unit, a fluid control unit, a mobile platform and a total reflection microscope thereon; the clamping platform being provided with a gene sequencing chip thereon; the reagent storage unit being configured to store a gene sequencing reagent, the fluid control unit being configured to pump the gene sequencing reagent from the reagent storage unit to the gene sequencing chip, the mobile platform being configured to drive the clamping platform to move toward or away from the total reflection microscope; and the total reflection microscope being configured to detect a gene sequence of a sample in the gene sequencing chip.. . ... Geno Llc

05/17/18 / #20180135087

Microorganisms and methods for the production of caprolactone

The invention provides non-naturally occurring microbial organisms containing caprolactone pathways having at least one exogenous nucleic acid encoding a butadiene pathway enzyme expressed in a sufficient amount to produce caprolactone. The invention additionally provides methods of using such microbial organisms to produce caprolactone by culturing a non-naturally occurring microbial organism containing caprolactone pathways as described herein under conditions and for a sufficient period of time to produce caprolactone.. ... Geno Llc

05/17/18 / #20180135082

Engineered microorgansims & methods for improved crotyl alcohol production

Disclosed are methods and engineered microorganisms that enhance or improve the production of crotyl alcohol. The engineered microorganisms include genetic modifications in alcohol dehydrogenase, alkene reductase or both enzymatic activities. ... Geno Llc

05/17/18 / #20180135080

Method for the monitoring of modified nucleases induced-gene editing events by molecular combing

Methods for detecting and characterizing large genomic rearrangements induced by modified nucleases at high resolution and for quantifying the frequency of the large genomic or gene rearrangements induced by modified nucleases using molecular combing.. . ... Geno Llc

05/17/18 / #20180135044

Non-unique barcodes in a genotyping assay

The present disclosure involves ctdna assays that interrogate many regions from a single sample with high precision and accuracy, while evaluating multiple forms of cancer-related genomic alterations including sequence mutations and structural alterations. The disclosure provides simplified yet robust methods that achieve high sensitivity and specificity by analyzing cancer genes using a limited pool of non-unique barcodes in combination with endogenous barcodes. ... Geno Llc

05/17/18 / #20180133310

Methods and compositions for treating herpes

The present disclosure provides, inter alia, certain combinations of immunogenic compositions (e.g., vaccines) against hsv-2 and antiviral therapy. The vaccines can be used therapeutically and/or prophylactically.. ... Geno Llc

05/10/18 / #20180127835

Gene expression signature for classification of tissue of origin of tumor samples

The present invention provides a process for classification of cancers and tissues of origin through the analysis of the expression patterns of specific micrornas and nucleic acid molecules relating thereto. Classification according to a microrna tree-based expression framework allows optimization of treatment, and determination of specific therapy.. ... Geno Llc

05/10/18 / #20180127755

Targeting micrornas for the treatment of liver cancer

Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a mirna. ... Geno Llc

05/10/18 / #20180127406

Arylcyclopropylamine based demethylase inhibitors of lsd1 and their medical use

The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula (i) as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection. Thus, in one specific aspect the invention relates to formulas (ii), (iii), (iv), (v), (vi), (vii), (viii), (ix).. ... Geno Llc

05/03/18 / #20180121601

Bioinformatics systems, apparatuses, and methods for performing secondary and/or tertiary processing

A system, method and apparatus for executing a bioinformatics analysis on genetic sequence data is provided. Particularly, a genomics analysis platform for executing a sequence analysis pipeline is provided. ... Geno Llc

05/03/18 / #20180119230

Systems and methods for analyzing nucleic acid

Increased sensitivity and specificity of characterizing patient-specific variations as mutations that are indicative of a cancer or other disease by identifying patient-specific tumor mutations by comparing tumor and normal sequence reads from the patient and filtering for mutations that are unique to the tumor. By comparing tumor sequence to a normal sequence from the same patient, false-positive mutation calls are minimized in the analysis.. ... Geno Llc

05/03/18 / #20180119203

Physical linkage preservation in dna storage

Disclosed herein are compositions, systems, kits and methods related to preserving physical linkage information of isolated dna subject to dna damage, and identifying a nucleic acid preservative. Physical linkage information and dna integrity may be preserved by methods relating to reassembly of chromatin onto isolated dna molecules so as to protect the nucleic acids, preserve physical linkage information, or size select molecules of interest. ... Geno Llc

05/03/18 / #20180119193

Expression of modified glycoproteins and glycopeptides

The present invention provides recombinant cells that contain a modification causing altered expression or function of at least one mannosyl transferase enzyme. As a result of the modification the cells produce a glycoprotein or glycopeptide that has an n-linked glycan profile that is simplified or humanized. ... Geno Llc

05/03/18 / #20180119132

Generation of synthetic genomes

Methods for generating synthetic genomes, for example synthetic genomes having desired properties or viable genomes of reduced size, are disclosed. Also disclosed are synthetic genomes produced by the methods disclosed herein and synthetic cells containing the synthetic genomes disclosed herein.. ... Geno Llc

05/03/18 / #20180119115

Recombinant dna polymerase for improved incorporation of nucleotide analogues

A composition comprising a recombinant dna polymerase and 3′-esterified nucleotide analogues is provided. The recombinant dna polymerase includes an amino acid sequence that is at least 90% homology with 9° n dna polymerase (seq id no: 1), and the recombinant dna polymerase includes at least two mutations at the positions corresponding to amino acid residues 141 and 143 of the 9° n dna polymerase. ... Geno Llc

04/19/18 / #20180107927

Architectures for training neural networks using biological sequences, conservation, and molecular phenotypes

The present disclosure provides methods and systems that can ascertain how genetic variants impact molecular phenotypes. Such methods and systems may use additional conservation information. ... Geno Llc

04/19/18 / #20180107784

Evaluating and calling sequences

Methods and systems for simultaneously evaluating genomic or biological sequences across multiple population members, and methods and systems for simultaneously calling normal and cancerous genomic or biological sequences from a mixed sample containing normal and cancerous material are disclosed. This may be achieved by evaluating the probability of one or more hypothesis being correct for a plurality of population members based on genomic or biological sequence information for the population. ... Geno Llc

04/19/18 / #20180106802

Methods for detecting and treating fungal infections

Methods are provided to detect and treat a fungal infection. The method may include the steps of obtaining a sample from a subject suspected of having a fungal infection, detecting an uncharacterized fungal protein (cimg_09001/cpsg_01366) in the sample, and determining the presence on the fungal infection if the uncharacterized fungal protein is detected.. ... Geno Llc

04/19/18 / #20180105864

Quality assessment of circulating cell-free dna using multiplexed droplet digital pcr

The present invention provides a method of determining integrity and/or quantity of cell free dna (cfdna) in a bio logical sample comprising amplifying target sequences with at least a first primer/probe set and at least a second primer probe/set, amplifying the target sequences of differing lengths, and monitoring for detection of the labels of the oligonucleotide probes, and determining the integrity and/or quantity of the cfdna based on the level of detection of the label of the oligonucleotide probe from the first primer/probe set compared to the level detection of the label of the oligonucleotide probe from the second primer/probe set. The present invention also provides methods for generating a library with the cfdna for sequencing and analysis.. ... Geno Llc

04/19/18 / #20180105808

Methods and systems for barcoding nucleic acid molecules from individual cells or cell populations

The present disclosure provides methods, compositions and systems for analyzing individual cells or cell populations through a partitioned analysis of contents of individual cells or cell populations, such as cancer cells and cells of the immune system. Individual cells or cell populations may be co-partitioned with processing reagents for accessing cellular contents, and for uniquely identifying the content of a given cell or cell population, and subsequently analyzing the content of the cell and characterizing it as having derived from an individual cell or cell population, including analysis and characterization of nucleic acid(s) from the cell through sequencing.. ... Geno Llc

04/19/18 / #20180104359

Recombinant virus replicon systems and uses thereof

The present disclosure generally relates to viral-based expression systems suitable for the production of molecules of interest. The disclosure relates to nucleic acid constructs, such as expression vectors, containing a modified replicon rna which includes a modified 5′-unstranslated region (5′-utr) and, optionally, at least some of its original viral sequence encoding structural proteins having been deleted. ... Geno Llc

04/12/18 / #20180101951

Method and system for processing image

The present disclosure provides a method and a system for processing an image. The method includes: an image pre-processing step, including analyzing an image input to be processed so as to obtain a first image; and a spot detecting step, including analyzing the first image so as to compute a spot determining threshold; analyzing the first image so as to acquire a candidate pixel spot, and judging whether the candidate pixel spot is the spot according to the spot determining threshold; computing a sub-pixel center coordinate of the spot and an intensity value of the sub-pixel center coordinate if yes; and discarding the candidate pixel spot if no. ... Geno Llc

04/12/18 / #20180100202

Method for identifying or detecting genomic rearrangements in a biological sample

A method for detection, visualization and/or comparison of polynucleotide sequences of interest using specially designed sets of long and short probes that enhance resolution and simplify visualization and detection. Probe compositions useful for practicing this method and procedures for identifying useful probes and probe combinations. ... Geno Llc

04/12/18 / #20180100172

Preparation of 6-aminocaproic acid from 5-formyl valeric acid

The invention relates to a method for preparing 6-aminocaproic acid (hereinafter also referred to as ‘6-aca’) using a biocatalyst. The invention further relates to a method for preparing ϵ-caprolactam (hereafter referred to as ‘caprolactam’) by cyclising such 6-aca. ... Geno Llc

04/05/18 / #20180096098

Method of nucleic acid fragment detection

A method of nucleic acid fragment detection includes capturing a target nucleic acid fragment by an oligonucleotide probe to form a hybridised double strand. The oligonucleotide probe has an identification sequence complementary to the target nucleic acid fragment and a reproducible sequence. ... Geno Llc

04/05/18 / #20180095039

A biosensor

Disclosed herein is an apparatus comprising: a plurality of locations configured to have probes attached thereto, wherein interaction between the probes and an analyte generates a signal; an optical system comprising a plurality of collimators; a sensor comprising a plurality of pixels configured to detect the signal; wherein the collimators are configured to essentially prevent light from passing if a deviation of a propagation direction of the light from an optical axis of the collimators is greater than a threshold.. . ... Geno Llc

04/05/18 / #20180094315

Methods and systems for processing polynucleotides

The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.. ... Geno Llc

04/05/18 / #20180094314

Methods and systems for processing polynucleotides

The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.. ... Geno Llc

04/05/18 / #20180094313

Methods and systems for processing polynucleotides

The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.. ... Geno Llc

04/05/18 / #20180094312

Methods and systems for processing polynucleotides

The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.. ... Geno Llc

04/05/18 / #20180094298

Compositions and methods for sample processing

This disclosure provides methods and compositions for sample processing, particularly for sequencing applications. Included within this disclosure are bead compositions, such as diverse libraries of beads attached to large numbers of oligonucleotides containing barcodes. ... Geno Llc

03/29/18 / #20180089369

Systems and methods for sequence encoding, storage, and compression

. . Genomic data is written to disk in a compact format by dividing the data into segments and encoding each segment with the smallest number of bits per character necessary for whatever alphabet of characters appears in that segment. A computer system dynamically chooses the segment boundaries for maximum space savings. ... Geno Llc

03/29/18 / #20180087103

High throughput nucleic acid sequencing by expansion and related methods

Nucleic acid sequencing methods and related products and methods for detection and presentation of the same are disclosed. Methods for sequencing a target nucleic acid comprise providing a daughter strand produced by a template-directed synthesis, the daughter strand comprising a plurality of subunits coupled in a sequence corresponding to a contiguous nucleotide sequence of all or a portion of the target nucleic acid, wherein the individual subunits comprise a tether, at least one probe or nucleobase residue, and at least one selectively cleavable bond. ... Geno Llc

03/29/18 / #20180087018

Materials and methods for extended continuous flow fermentation of reduced genome bacteria

A two-vessel continuous flow system in conjunction with low mutation reduced genome bacterial strains provides a platform for long term extended fermentations. Such systems require modification of standard fermentation devices such as probes, pumps and monitoring systems as well as improved procedures for feed delivery, culture monitoring and product harvesting methods. ... Geno Llc

03/22/18 / #20180082012

Method and device for determining fraction of cell-free nucleic acids in biological sample and use thereof

Provided in the present disclosure are a method and a device for determining a fraction of cell free nucleic acids in a biological sample and use thereof, wherein the method comprises: (1) sequencing nucleic acids of a biological sample having free nucleic acids, in order to obtain sequencing results for a plurality of sequencing data; (2) based on the sequencing results, determining the number of nucleic acid molecules with a length falling within a preset range in the sample; and (3) based on the number of nucleic acid molecules with a length falling within the preset range, determining the ratio of free nucleic acids in the biological sample.. . ... Geno Llc

03/22/18 / #20180081717

Hashing data-processing steps in workflow environments

Various approaches for data storage and retrieval for a computer memory include processing a computational workflow having multiple data-processing steps, generating and storing a first hash value associated with a first step of the data-processing steps based on an input to the first step, generating and storing a second hash value associated with a second step of the data-processing steps based on the generated first hash value, and reconstructing a computational state of the workflow based on the second hash value, and thereby avoid re-execution of a portion of the workflow corresponding to the second hash value.. . ... Geno Llc

03/22/18 / #20180080075

Methods for analyzing nucleic acids from single cells

Aspects of the present invention include analyzing nucleic acids from single cells using methods that include using tagged polynucleotides containing multiplex identifier sequences.. . ... Geno Llc

03/22/18 / #20180080065

Universal method for extracting nucleic acid molecules from a diverse population of one or more types of microbes in a sample

Disclosed herein are methods of extracting genetic material from a diverse population of one or more types of microbes in a sample. Microbes can be prokaryotes or eukaryotes and may include bacteria, archaea, fungi, protozoa, helminths, parasites, viruses, phages, and others. ... Geno Llc

03/22/18 / #20180079709

(hetero)aryl cyclopropylamine compounds as lsd1 inhibitors

The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula (i) as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.. . ... Geno Llc

03/15/18 / #20180071467

System and method for portable nitric oxide delivery

An apparatus for delivering no includes a nitric oxide-releasing agent, a reactor cartridge containing a reducing agent that coverts a nitric oxide-releasing agent to nitric oxide (no), a portable console, and a respiratory assist device configured to deliver the no.. . ... Geno Llc

03/08/18 / #20180067038

Devices and methods for high-throughput single cell and biomolecule analysis and retrieval in a microfluidic chip

Described here is a device comprising a microfluidic chip and an acoustic transducer external to the microfluidic chip, wherein the microfluidic chip comprises a channel in communication with a microwell having a volume less than one microliter, and wherein the acoustic transducer is coupled to the microfluidic chip via a coupling medium. Also described here is a method for analyzing a cell or a biomolecule, comprising applying a focused acoustic beam to a microfluidic chip comprising a channel in fluid communication with a microwell having a volume less than one microliter, wherein the microwell comprises an aqueous compartment comprising a cell or a biomolecule, wherein the channel comprises a non-aqueous liquid phase immiscible with the aqueous compartment which encapsulates the aqueous compartment in the microwell, and wherein the acoustic beam displaces a meniscus at an interface of the aqueous compartment and the non-aqueous liquid phase thereby ejecting the aqueous compartment from the microwell into the channel as an aqueous droplet.. ... Geno Llc

03/08/18 / #20180066324

Method for detecting lung cancer using lung cancer-specific methylation marker gene

The present invention relates to a method for detecting lung cancer using a lung cancer-specific biomarker, and more particularly to a biomarker for lung cancer diagnosis, which can detect methylation of pcdhga12 gene whose 5′utr or exon 1 region is specifically methylated in lung cancer cells, and to a method of detecting lung cancer and the stage of its progression using the biomarker. The diagnostic kit according to the present invention makes it possible to diagnose lung cancer at an early stage in an accurate and rapid manner compared to conventional methods and can be used for prognosis and monitoring of lung cancer and the stage of its progression.. ... Geno Llc

03/08/18 / #20180065907

Process and systems for obtaining 1,4-butanediol from fermentation broths

A process of purifying 1,4-butanediol (1,4-bdo) from a fermentation broth including separating solid materials, salts and water, and subjecting the resulting material to a two, three or four column distillation system, that can include a wiped film evaporator to produce a purified 1,4-butanediol.. . ... Geno Llc

03/01/18 / #20180060480

Systems and methods for detecting recombination

A method for screening for disease in a genomic sample is includes receiving a representation of a reference genome comprising a sequence of symbols. The presence of a predicted mutational event is identified in a location of the reference genome. ... Geno Llc

03/01/18 / #20180057824

Genetically engineered vibrio sp. and uses thereof

The present disclosure provides engineered vibrio sp. Organisms. ... Geno Llc

02/22/18 / #20180053328

Systems and methods for processing computational workflows

In one embodiment, a method of processing a computational workflow comprises receiving a description of a computational workflow. The description comprises a plurality of steps, in which each step has at least one input and at least one output, and further wherein an input from a second step depends on an output from a first step. ... Geno Llc

02/22/18 / #20180051333

Nucleic acid analysis by random mixtures of non-overlapping fragments

The invention provides methods and kits for ordering sequence information derived from one or more target polynucleotides. In one aspect, one or more tiers or levels of fragmentation and aliquoting are generated, after which sequence information is obtained from fragments in a final level or tier. ... Geno Llc

02/22/18 / #20180051321

Compositions and methods for sample processing

This disclosure provides methods and compositions for sample processing, particularly for sequencing applications. Included within this disclosure are bead compositions, such as diverse libraries of beads attached to large numbers of oligonucleotides containing barcodes. ... Geno Llc

02/22/18 / #20180051280

Materials and methods for the synthesis of error-minimized nucleic acid molecules

The present invention provides materials and methods useful for error correction of nucleic acid molecules. In one embodiment of the invention, a first plurality of double-stranded nucleic acid molecules having a nucleotide mismatch are fragmented by exposure to a molecule having unidirectional mismatch endonuclease activity. ... Geno Llc

02/22/18 / #20180050946

Environmentally sustainable cement composition, its use for inerting dredging sediments/sludges, relative method and apparatus for inerting

A cement composition based on a sulfoaluminate clinker is described, together with its use for agglomerating and inerting sediment/dredging sludge, and the relative inerting method and apparatus.. . ... Geno Llc

02/15/18 / #20180044730

Ultra-low coverage genome sequencing and uses thereof

Methods are provided for analyzing one or more genetic samples, comprising procuring one or more genetic samples comprising genetic material from one or more individuals and sequencing the genetic material using non-targeted, ultra-low coverage sequencing to obtain genetic information for individual associated with the one or more genetic samples. Personal and genetic information associated with the individuals is stored in a database for retrieval and manipulation.. ... Geno Llc

02/15/18 / #20180044725

Polynucleotide binding protein sequencing

The present disclosure relates to systems, methods and compositions for single molecule electronic sequencing of template nucleic acids using nanosensors. The nanosensors of the invention improve the measurement of polynucleotides by assimilating authentic polynucleotide binding proteins (“pbps”) in place of conventional pore-forming proteins that do not normally interact with polynucleotides. ... Geno Llc

02/15/18 / #20180042936

Maintenance therapy using tianeptine

The present application provides a method for treating treatment-resistant depression in a patient in need thereof, comprising administering to said patient a therapeutically effective amount of tianeptine, subsequent to a ketamine treatment; also provided is a method of treating suicidal ideation (si), post-traumatic stress disorder (ptsd), mild cognitive impairment (mci) or pre-dementia co-morbid with symptoms of depression; and further provided is maintenance therapy for depression remission.. . ... Geno Llc

02/08/18 / #20180039730

Computer method and system of identifying genomic mutations using graph-based local assembly

Computer-implemented methods and systems for performing a local assembly of a genomic region of interest include the de novo or assisted creation of a directed graph, such as a directed acyclic graph (dag), from a plurality of obtained nucleotide sequence reads. First and second sequence reads are aligned to each other to define at least one node of the dag. ... Geno Llc

02/01/18 / #20180031520

Organic transistor-based system for electrophysiological monitoring of cells and method for the monitoring of the cells

An organic transistor-based system for electrophysiological monitoring of cells is disclosed. The system includes a plurality of organic transistors each comprising: a floating gate electrode; a source electrode and a drain electrode; an organic semiconductor; an insulating layer; and a sensing area. ... Geno Llc

02/01/18 / #20180030540

Systems and methods for expression-based classification of thyroid tissue

A system for classifying thyroid nodule tissue as malignant or benign is provided that is based on the identification of sets of gene transcripts, which are characterized in that changes in expression of each gene transcript within a set of gene transcripts can be correlated to with either malignant or benign thyroid nodule disease. The thyroid classification system provides for sets of “thyroid classifying” target sequences and further provides for combinations of polynucleotide probes and primers derived there from. ... Geno Llc

02/01/18 / #20180030527

Methods and compositions for generating and amplifying dna libraries for sensitive detection and analysis of dna methylation

The present invention regards a variety of methods and compositions for obtaining epigenetic information, such as dna methylation patterns, through the preparation, amplification and analysis of methylome libraries. In particular, the method employs preparation of a dna molecule by digesting the dna molecule with at least one methylation-sensitive restriction enzyme; incorporating a nucleic acid molecule into at least some of the digested dna molecules by either (1) incorporating at least one primer from a plurality of primers that have a 5′ constant sequence and a 3′ variable sequence, wherein the primers are substantially non-self-complementary and substantially non-complementary to other primers in the plurality; or (2) incorporating an oligonucleotide having an inverted repeat and a loop under conditions wherein the oligonucleotide becomes blunt-end ligated to one strand of the digested dna molecule, followed by polymerization from a 3′ hydroxyl group present in a nick in the oligonucleotide-linked molecule; and amplifying one or more of the dna molecules. ... Geno Llc

02/01/18 / #20180030512

Capsule array devices and methods of use

This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample preparation operations. ... Geno Llc

02/01/18 / #20180030484

Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,4-butanediol related thereto

Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (bdo). ... Geno Llc

01/18/18 / #20180018423

Systems and methods for reconciling variants in sequence data relative to reference sequence data

Techniques for identifying variations in sequence data relative to reference sequence data. The techniques include accessing information specifying multiple sets of variants in the sequence data relative to reference sequence data, each of the multiple sets of variants being generated by using a respective variant identification technique; and determining, using the information specifying the multiple sets of variants in the sequence data, a reconciled set of variants in the sequence data relative to the reference sequence data, the determining comprising: determining whether a first variant is present at a first position in the sequence data based, at least in part, on one or more variants at one or more other positions in the sequence data.. ... Geno Llc

01/18/18 / #20180016644

Method for detecting methylation of colorectal cancer specific methylation marker gene for colorectal cancer diagnosis

The present disclosure relates to a method for detecting methylation of the bowel-cancer-specific methylation marker gpm6a (nm_201591, glycoprotein m6a) gene in order to diagnose bowel cancer, and more specifically relates to a method for providing information for diagnosing bowel cancer by detecting the methylation of a bowel-cancer-specific marker gene that is specifically methylated in bowel cancer cells. The method for detecting methylation and a diagnostic composition, kit and nucleic-acid chip according to the present disclosure can be used to advantage in diagnosing bowel cancer more accurately and quickly than by normal methods as they permit bowel cancer to be diagnosed at the initial genetic transformation step and so allow early diagnosis.. ... Geno Llc

01/18/18 / #20180016643

Diagnosis kit and chip for bladder cancer using bladder cancer specific methylation marker gene

The present invention relates to a kit and nucleic acid chip for diagnosing bladder cancer using a bladder cancer-specific marker gene. More particularly, the invention relates to a kit and nucleic acid chip for diagnosing bladder cancer, which can detect the promoter methylation of a bladder cancer-specific gene, the promoter or exon region of which is methylated specifically in transformed cells of bladder cancer. ... Geno Llc

01/18/18 / #20180016634

Methods and systems for processing polynucleotides

The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.. ... Geno Llc

01/18/18 / #20180016628

Self-assembled single molecule arrays and uses thereof

The present invention provides methods of making and using self-assembled arrays of single polynucleotide molecules for carrying out a variety of large-scale genetic measurements, such as gene expression analysis, gene copy number assessment, and the like. Random arrays used in the invention are “self-assembled” in the sense that they are formed by deposition of polynucleotide molecules onto a surface where they become fixed at random locations. ... Geno Llc

01/18/18 / #20180015473

Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same

The disclosure provides devices, systems and methods for the generation of encapsulated reagents and the partitioning of encapsulated reagents for use in subsequent analyses and/or processing, such as in the field of biological analyses and characterization.. . ... Geno Llc

01/18/18 / #20180015472

Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same

The disclosure provides devices, systems and methods for the generation of encapsulated reagents and the partitioning of encapsulated reagents for use in subsequent analyses and/or processing, such as in the field of biological analyses and characterization.. . ... Geno Llc

01/11/18 / #20180013017

Optical sensor and manufacturing method thereof

Some embodiments of the present disclosure provide an optical sensor. The optical sensor includes a semiconductive substrate; a light sensing region on the semiconductive substrate; a waveguide region configured to guide light from a wave insert portion through a waveguide portion and to a sample holding portion; and an interconnect region below the waveguide region, and the interconnect region being disposed above the light sensing region. ... Geno Llc

01/11/18 / #20180008984

Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same

The disclosure provides devices, systems and methods for the generation of encapsulated reagents and the partitioning of encapsulated reagents for use in subsequent analyses and/or processing, such as in the field of biological analyses and characterization.. . ... Geno Llc

01/11/18 / #20180008317

Bone compression and fixation devices

A bone screw, for drawing first and second bone fragments together, includes a shaft having a distal section and a proximal section. The distal section has a first external male screw thread and a minor diameter. ... Geno Llc

01/04/18 / #20180004891

Method and apparatus for identifying tandem repeats in a nucleotide sequence

A method and corresponding apparatus for identifying tandem repeats in a nucleotide sequence is described. Tandem repeats can be identified by identifying one or more lines present in a self-alignment plot of the nucleotide sequence. ... Geno Llc

01/04/18 / #20180002735

Efficient arrays of amplified polynucleotides

The present invention is related generally to analysis of polynucleotides, particularly polynucleotides derived from genomic dna. The invention provides methods, compositions and systems for such analysis. ... Geno Llc

01/04/18 / #20180002731

Methods of constructing a circular template and detecting dna molecules

A method of constructing a circular template includes preparing a partially double stranded linear dna molecule, and incubating the partially double stranded linear dna molecule with a ligase capable of intra-molecular ligation of single stranded dna molecules to generate a partially double stranded circular dna molecule. A method of detecting dna molecules includes the following steps. ... Geno Llc

12/28/17 / #20170369913

Method of producing & processing diamines

Provided is a method of producing and isolating a diamine produced by microbial fermentation that minimizes undesirable salt formation to provide a lower cost process.. . ... Geno Llc








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