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Genomatica Inc patents


Recent patent applications related to Genomatica Inc. Genomatica Inc is listed as an Agent/Assignee. Note: Genomatica Inc may have other listings under different names/spellings. We're not affiliated with Genomatica Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "G" | Genomatica Inc-related inventors


Microorganisms for the production of aniline

A non-naturally occurring microbial organism having an aniline pathway includes at least one exogenous nucleic acid encoding an aniline pathway enzyme expressed in a sufficient amount to produce aniline. The aniline pathway includes (1) an aminodeoxychorismate synthase, an aminodeoxychorismate lyase, and a 4-aminobenzoate carboxylyase or (2) an anthranilate synthase and an anthranilate decarboxylase. ... Genomatica Inc

Microorganisms and methods for the biosynthesis of butadiene

The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene.. ... Genomatica Inc

Microorganisms for the production of 1,4-butanediol

The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (bdo) pathway comprising at least one exogenous nucleic acid encoding a bdo pathway enzyme expressed in a sufficient amount to produce bdo. The invention additionally provides methods of using such microbial organisms to produce bdo.. ... Genomatica Inc

Microorganisms and methods for the production of caprolactone

The invention provides non-naturally occurring microbial organisms containing caprolactone pathways having at least one exogenous nucleic acid encoding a butadiene pathway enzyme expressed in a sufficient amount to produce caprolactone. The invention additionally provides methods of using such microbial organisms to produce caprolactone by culturing a non-naturally occurring microbial organism containing caprolactone pathways as described herein under conditions and for a sufficient period of time to produce caprolactone.. ... Genomatica Inc

Engineered microorgansims & methods for improved crotyl alcohol production

Disclosed are methods and engineered microorganisms that enhance or improve the production of crotyl alcohol. The engineered microorganisms include genetic modifications in alcohol dehydrogenase, alkene reductase or both enzymatic activities. ... Genomatica Inc

Preparation of 6-aminocaproic acid from 5-formyl valeric acid

The invention relates to a method for preparing 6-aminocaproic acid (hereinafter also referred to as ‘6-aca’) using a biocatalyst. The invention further relates to a method for preparing ϵ-caprolactam (hereafter referred to as ‘caprolactam’) by cyclising such 6-aca. ... Genomatica Inc

Process and systems for obtaining 1,4-butanediol from fermentation broths

A process of purifying 1,4-butanediol (1,4-bdo) from a fermentation broth including separating solid materials, salts and water, and subjecting the resulting material to a two, three or four column distillation system, that can include a wiped film evaporator to produce a purified 1,4-butanediol.. . ... Genomatica Inc

Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,4-butanediol related thereto

Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 1,4-butanediol (bdo). ... Genomatica Inc

Method of producing & processing diamines

Provided is a method of producing and isolating a diamine produced by microbial fermentation that minimizes undesirable salt formation to provide a lower cost process.. . ... Genomatica Inc

Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds

The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate or related products using the microbial organisms.. ... Genomatica Inc

Process and systems for obtaining 1,4-butanediol from fermentation broths

A process of purifying 1,4-butanediol (1,4-bdo) from a fermentation broth including separating solid materials, salts and water, and subjecting the resulting material to a two, three or four column distillation system, that can include a wiped film evaporator to produce a purified 1,4-butanediol.. . ... Genomatica Inc

Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene

The invention provides non-naturally occurring microbial organisms having a toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4-pentadienoate, 3-butene-1 ol or 1,3-butadiene pathway. The invention additionally provides methods of using such organisms to produce toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4-pentadienoate, 3-butene-1 ol or 1,3-butadiene.. ... Genomatica Inc

Organisms for the production of 1,3-butanediol

A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-bdo) pathway having at least one exogenous nucleic acid encoding a 1,3-bdo pathway enzyme expressed in a sufficient amount to produce 1,3-bdo. The pathway includes an enzyme selected from a 2-amino-4-ketopentanoate (akp) thiolase, an akp dehydrogenase, a 2-amino-4-hydroxypentanoate aminotransferase, a 2-amino-4-hydroxypentanoate oxidoreductase (deaminating), a 2-oxo-4-hydroxypentanoate decarboxylase, a 3-hydroxybutyraldehyde reductase, an akp aminotransferase, an akp oxidoreductase (deaminating), a 2,4-dioxopentanoate decarboxylase, a 3-oxobutyraldehyde reductase (ketone reducing), a 3-oxobutyraldehyde reductase (aldehyde reducing), a 4-hydroxy-2-butanone reductase, an akp decarboxylase, a 4-aminobutan-2-one aminotransferase, a 4-aminobutan-2-one oxidoreductase (deaminating), a 4-aminobutan-2-one ammonia-lyase, a butenone hydratase, an akp ammonia-lyase, an acetylacrylate decarboxylase, an acetoacetyl-coa reductase (coa-dependent, aldehyde forming), an acetoacetyl-coa reductase (coa-dependent, alcohol forming), an acetoacetyl-coa reductase (ketone reducing), a 3-hydroxybutyryl-coa reductase (aldehyde forming), a 3-hydroxybutyryl-coa reductase (alcohol forming), a 4-hydroxybutyryl-coa dehydratase, and a crotonase. ... Genomatica Inc

Eukaryotic organisms and methods for increasing the availability of cytosolic acetyl-coa, and for producing 1,3-butanediol

Provided herein are non-naturally occurring eukaryotic organisms that can be engineered to produce and increase the availability of cytosolic acetyl-coa. Also provided herein are non-naturally occurring eukaryotic organisms having a 1,3-butanediol (1,3-bdo) pathway. ... Genomatica Inc

08/24/17 / #20170240931

Methods and organisms for the growth-coupled production of 1,4-butanediol

The invention provides a non-naturally occurring microorganism comprising one or more gene disruptions, the one or more gene disruptions occurring in genes encoding an enzyme obligatory to coupling 1,4-butanediol production to growth of the microorganism when the gene disruption reduces an activity of the enzyme, whereby the one or more gene disruptions confers stable growth-coupled production of 1,4-butanediol onto the non-naturally occurring microorganism. The microorganism can further comprise a gene encoding an enzyme in a 1,4-butanediol (bdo) biosynthetic pathway. ... Genomatica Inc

08/03/17 / #20170218414

Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid

The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. ... Genomatica Inc

07/06/17 / #20170191085

Microorganisms and methods for the production of butadiene using acetyl-coa

The invention provides non-naturally occurring microbial organisms containing butadiene or 2,4-pentadienoate pathways comprising at least one exogenous nucleic acid encoding a butadiene or 2,4-pentadienoate pathway enzyme expressed in a sufficient amount to produce butadiene or 2,4-pentadienoate. The organism can further contain a hydrogen synthesis pathway. ... Genomatica Inc

06/29/17 / #20170183694

Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds

The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa and/or putrescine pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa and/or putrescine or related products using the microbial organisms.. ... Genomatica Inc

06/15/17 / #20170166931

Microorganisms for producing 4c-5c compounds with unsaturation and methods related thereto

The invention provides a non-naturally occurring microbial organism having a butadiene, crotyl alcohol, 2,4-pentadienoate, 3-buten-2-ol, or 3-buten-1-ol, pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a pathway. ... Genomatica Inc

06/08/17 / #20170159075

Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis

The invention provides non-naturally occurring microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing carbon flux through acetyl-coa. In some embodiments, the microbial organisms having such pathways also include pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation. ... Genomatica Inc

05/11/17 / #20170130234

Microorganisms for the production of adipic acid and other compounds

The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. ... Genomatica Inc

04/06/17 / #20170096689

Semi-synthetic terephthalic acid via microorganisms that produce muconic acid

The invention provides a non-naturally occurring microbial organism having a muconate pathway having at least one exogenous nucleic acid encoding a muconate pathway enzyme expressed in a sufficient amount to produce muconate. The muconate pathway including an enzyme selected from the group consisting of a beta-ketothiolase, a beta-ketoadipyl-coa hydrolase, a beta-ketoadipyl-coa transferase, a beta-ketoadipyl-coa ligase, a 2-fumarylacetate reductase, a 2-fumarylacetate dehydrogenase, a trans-3-hydroxy-4-hexendioate dehydratase, a 2-fumarylacetate aminotransferase, a 2-fumarylacetate aminating oxidoreductase, a trans-3-amino-4-hexenoate deaminase, a beta-ketoadipate enol-lactone hydrolase, a muconolactone isomerase, a muconate cycloisomerase, a beta-ketoadipyl-coa dehydrogenase, a 3-hydroxyadipyl-coa dehydratase, a 2,3-dehydroadipyl-coa transferase, a 2,3-dehydroadipyl-coa hydrolase, a 2,3-dehydroadipyl-coa ligase, a muconate reductase, a 2-maleylacetate reductase, a 2-maleylacetate dehydrogenase, a cis-3-hydroxy-4-hexendioate dehydratase, a 2-maleylacetate aminoatransferase, a 2-maleylacetate aminating oxidoreductase, a cis-3-amino-4-hexendioate deaminase, and a muconate cis/trans isomerase. ... Genomatica Inc

03/30/17 / #20170088840

Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors

The invention provides a non-naturally occurring microbial biocatalyst including a microbial organism having a 4-hydroxybutanoic acid (4-hb) biosynthetic pathway having at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-coa synthetase, coa-dependent succinic semialdehyde dehydrogenase, or α-ketoglutarate decarboxylase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce monomeric 4-hydroxybutanoic acid (4-hb). Also provided is a non-naturally occurring microbial biocatalyst including a microbial organism having 4-hydroxybutanoic acid (4-hb) and 1,4-butanediol (bdo) biosynthetic pathways, the pathways include at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-coa synthetase, coa-dependent succinic semialdehyde dehydrogenase, 4-hydroxybutyrate:coa transferase, 4-butyrate kinase, phosphotransbutyrylase, α-ketoglutarate decarboxylase, aldehyde dehydrogenase, alcohol dehydrogenase or an aldehyde/alcohol dehydrogenase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce 1,4-butanediol (bdo). ... Genomatica Inc

03/16/17 / #20170073708

Adipate (ester or thioester) synthesis

The present invention relates to a method for preparing an adipate ester or thioester. The invention further relates to a method for preparing adipic acid from said ester or thioester. ... Genomatica Inc

03/16/17 / #20170073691

Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, for producing methacrylic acid

Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such reducing equivalents can be used to increase the product yield of organic compounds produced by the microbial organism, such as 3-hydroxyisobutyrate or maa. ... Genomatica Inc

02/16/17 / #20170044572

Microorganisms and methods for the biosynthesis of butadiene

The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene.. ... Genomatica Inc

02/02/17 / #20170029852

Process for the production of 1,4-butanediol

Process for the synthesis of 1,4-butanediol comprising fermentation of a culture medium by a microorganism provided with at least one metabolic pathway for the synthesis of 1,4-butanediol and able to use saccharose, in which said culture medium comprises a glucose and saccharose mixture comprising, based on the combined weight of glucose and saccharose, 10-90% by weight of saccharose and 10-90% by weight of glucose.. . ... Genomatica Inc

01/26/17 / #20170022524

Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors

The invention provides a non-naturally occurring microbial biocatalyst including a microbial organism having a 4-hydroxybutanoic acid (4-hb) biosynthetic pathway having at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-coa synthetase, coa-dependent succinic semialdehyde dehydrogenase, or α-ketoglutarate decarboxylase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce monomeric 4-hydroxybutanoic acid (4-hb). Also provided is a non-naturally occurring microbial biocatalyst including a microbial organism having 4-hydroxybutanoic acid (4-hb) and 1,4-butanediol (bdo) biosynthetic pathways, the pathways include at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-coa synthetase, coa-dependent succinic semialdehyde dehydrogenase, 4-hydroxybutyrate:coa transferase, 4-butyrate kinase, phosphotransbutyrylase, α-ketoglutarate decarboxylase, aldehyde dehydrogenase, alcohol dehydrogenase or an aldehyde/alcohol dehydrogenase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce 1,4-butanediol (bdo). ... Genomatica Inc

01/26/17 / #20170022508

Microorganisms for the production of aniline

A non-naturally occurring microbial organism having an aniline pathway includes at least one exogenous nucleic acid encoding an aniline pathway enzyme expressed in a sufficient amount to produce aniline. The aniline pathway includes (1) an aminodeoxychorismate synthase, an aminodeoxychorismate lyase, and a 4-aminobenzoate carboxylyase or (2) an anthranilate synthase and an anthranilate decarboxylase. ... Genomatica Inc

01/12/17 / #20170008828

Methods for the synthesis of olefins and derivatives

The invention provides a method of producing acrylic acid. The method includes contacting fumaric acid with a sufficient amount of ethylene in the presence of a cross-metathesis transformation catalyst to produce about two moles of acrylic acid per mole of fumaric acid. ... Genomatica Inc








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