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Georgetown University patents


Recent patent applications related to Georgetown University. Georgetown University is listed as an Agent/Assignee. Note: Georgetown University may have other listings under different names/spellings. We're not affiliated with Georgetown University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "G" | Georgetown University-related inventors


Methods of assessing future memory loss by measuring polyunsaturated fatty acids

The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise determining the influx of polyunsaturated fatty acids (pu fas) into the brain from plasma in a test subject and comparing this measured influx to a normal standard influx. ... Georgetown University

Targeting tumor cells with chemotherapeutic agents conjugated to matriptase antibodies

The present invention relates to matriptase antibodies and immunoconjugates of matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of matriptase-expressing cancer cells, such as those of multiple myeloma and breast cancers. In particular, immunoconjugates comprising a matriptase monoclonal antibody and anticancer agents such as auristatin, including monomethyl auristatin e (mmae) and monomethyl auristatin f (mmaf) are introduced, which have potent antitumor activity in vivo. ... Georgetown University

Use of methadone metabolites for treatment of anxiety and depression

Disclosed are methods of treating anxiety or depression, comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (emdp), 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (eddp), and pharmaceutically acceptable salts thereof.. . ... Georgetown University

Discovery and analysis of drug-related side effects

Disclosed herein are methods and systems for discovering and analyzing drug related side effects, which are also referred to herein as “off-target responses”. Side effects can be positive/beneficial side effects or negative/undesirable side effects. ... Georgetown University

Predicting drug-target interactions and uses for drug repositioning and repurposing

Described herein are methods of predicting drug-target interactions and methods of using the information for drug repurposing. The methods described herein combine different descriptors, including, for example, atom pair similarity, shape, topology and chemical signatures, physico-chemical functional descriptors, contact points of the ligand and the target protein, chemical similarity, and docking score.. ... Georgetown University

Novel ezrin inhibitors and methods of making and using

The invention encompasses compound and pharmaceutical composition comprising the compound of the following formula (i): or pharmaceutically acceptable salts or prodrugs thereof, that are useful for inhibiting ezrin protein in a cell or for inhibiting the growh of a cancer cell.. . ... Georgetown University

Compounds and methods of use thereof for treating tumors

The invention encompasses novel compounds and pharmaceutically acceptable salts thereof and compositions including therapeutically or prophylactically effective amounts of such compounds or pharmaceutically acceptable salts thereof. The invention also encompasses methods for treating or preventing diseases and disorders associated with abnormal cell growth, for example, treating or preventing cancer or tumor growth, which methods include administering to a mammal in need thereof a composition comprising a therapeutically or prophylactically effective amount of a compound of the invention or a pharmaceutically acceptable salt thereof.. ... Georgetown University

Treatment for exposure to nerve agent

The present application provides methods of preventing and treating the toxic effects of exposure to organophosphate agents. In embodiments, targeted cationic liposome complexes delivering nucleic acid molecules encoding butyrylcholinesterase and a polyproline rich peptide are administered. ... Georgetown University

Dryer for preparation of dry nanoparticles

A system for producing dry nanoparticles from a liquid includes a closed tubing system which incorporates a mister, heater and an electrostatic collector therein. The system is able to produce dry nanoparticles from liquid-suspensions and from solvent solutions.. ... Georgetown University

Glutathione-cleavable prodrug and methods of use thereof

A glutathione-cleavable prodrug is provided herein, as well as methods for its use in treating cancer, including triple negative breast cancer. The prodrug can be cleaved by glutathione under physiological conditions to generate a biologically active agent. ... Georgetown University

Systems and methods for automated control of animal training and discrimination learning

Monitoring systems and methods for tracking movement of one or more animals in an enclosure, such as a fish tank, include introducing various stimuli, such as food, light, and auditory stimuli, and tracking the movement of the animals in response to these stimuli. Movement patterns of the animals can be determined and analyzed from data obtain from cameras that record images/videos of the relevant portions of the enclosure.. ... Georgetown University

Mint mask and methods of use thereof

Provided are methods and devices useful for treating a respiratory disease or disorder involving the central or upper airways. The methods and devices deliver to central or upper airways of a subject a vapor or aerosol comprising an effective amount of an active ingredient selected from the group consisting of menthol, menthone, neomenthol, isomenthol, and menthofuran. ... Georgetown University

Stripline detector for in situ battery and fuel cell nmr

Provided are batteries and fuel cells incorporating a stripline detector for use in nuclear magnetic resonance (nmr). The stripline batteries and fuel cells can be used for in situ nmr measurement of battery or fuel cell chemistry. ... Georgetown University

Intelligent medical hypertext information translator

Technology for providing a translated content item containing medical terms is disclosed. In one example, a method is used for providing a translated content item and a plurality of actionable options. ... Georgetown University

12/07/17 / #20170351742

Application programming interface and hypergraph transfer protocol supporting a global hypergraph approach to reducing complexity for accelerated multi-disciplinary scientific discovery

A system and method for connecting one or more client applications with one or more knowledge representation servers and communicating there between includes an application programming interface (api) and a hypergraph transfer protocol (hgtp), for facilitating communication between the one or more client applications and one or more knowledge representation servers responsive to a client application request. The client application request includes an api call for a specific entity that is received by a first knowledge representation server. ... Georgetown University

11/09/17 / #20170322682

System and method for detecting, collecting, analyzing, and communicating event-related information

A system and method involves detecting operational social disruptive events on a global scale, assigning disease or non-disease event staging and warnings to express data in more simplistic terms, modeling data in conjunction with linguistics analysis to establish responsive actions, generating visualization and modeling capabilities for communicating information, and modeling disease or non-disease propagation for containment and forecasting purposes.. . ... Georgetown University

08/31/17 / #20170246259

Compositions and methods of using interleukin-4 induced gene 1 (il-4i1)

The invention is directed to methods of promoting myelin formation in central nervous system (cns) tissue in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of interleukin-4 induced gene 1 (il4-i1) protein. The invention is also directed to methods of monitoring the progression of conditions marked by an impairment of myelin formation in the cns comprising assessing the levels or activity of il4-i1 in activated macrophages obtained from the subject.. ... Georgetown University

08/31/17 / #20170246145

Use of artemisinin for treating tumors induced by oncogenic viruses and for treating viral infections

In certain aspects, the invention relates to methods of treating proliferative cervical disorders (such as cervical cancer and cervical dysplasia) and treating virus infection by administering artemisinin-related compounds. In certain aspects, the invention relates to methods of treating a tumor induced by an oncogenic virus, methods of killing or inhibiting a squamous cell carcinoma, and methods of inhibiting the replication of a virus, by administering artemisinin-related compounds.. ... Georgetown University

08/03/17 / #20170216287

Treating neural disease with tyrosine kinase inhibitors

Provided herein are methods of treating or preventing a neurodegenerative disease, a myodegenerative disease or a prion disease in a subject comprising administering a tyrosine kinase inhibitor.. . ... Georgetown University

07/27/17 / #20170213028

Methods, systems, and computer readable media for detecting covert timing channels

A mechanism called time-deterministic replay (tor) that can reproduce the execution of a program, including its precise timing. Without tor, reproducing the timing of an execution is difficult because there are many sources of timing variability. ... Georgetown University

06/15/17 / #20170165254

Treating flavivirus infections with amodiaquine and derivatives thereof

Methods of treating, preventing, and/or ameliorating a flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a flavivirus inhibitor. ... Georgetown University

06/08/17 / #20170157089

Methods and compositions for treating cancer

Methods and compositions provided herein relate to the treatment of cancer. In some embodiments, the compositions have utility in the treatment of cancers including glioblastoma multiforme and lung cancer.. ... Georgetown University

06/01/17 / #20170154410

Enhancing the legibility of images using monochromatic light sources

A system and method are described for enhancing readability of document images by operating on each document individually. Monochromatic light sources operating at different wavelengths of light can be used to obtain greyscale images. ... Georgetown University

05/18/17 / #20170136134

Manganese-oxo clusters as contrast agents for magnetic resonance imaging

Nanoparticles for use as magnetic resonance imaging contrast agents are described. The nanoparticles are made up of a polymeric support and a manganese-oxo or manganese-iron-oxo cluster having magnetic properties suitable of a contrast agent. ... Georgetown University

04/06/17 / #20170098053

Telegenetics

Disclosed herein are systems and methods that utilized a network of dispersed computing systems, specialized software, and other networking technology for providing remote communications for facilitating genetics counseling services between people or devices located at remote locations. The disclosed technology can utilize a centralized computing system including a central server system and one or more data warehouses. ... Georgetown University

03/30/17 / #20170087107

Benzenetricarboxylic acid and methods of use

Methods of treating or preventing cancer and/or a neurodegenerative disorder in a subject are provided. The methods comprise administering to a subject a therapeutically effective amount of 1,2,3-benzenetricarboxylic acid or a hydrate or pharmaceutically acceptable salt thereof.. ... Georgetown University

02/23/17 / #20170049182

Orthotic devices

The present invention relates to orthotic devices and footwear. In particular, the present invention relates to orthotic devices comprising a wedge configured to be placed beneath a forefoot.. ... Georgetown University

02/09/17 / #20170035331

Apparatus and method for delivery of antimicrobial during a transdermal sampling and delivery process

A device for introducing at least one antimicrobial in an exposed region of a user's skin caused while accessing interstitial fluid includes a substrate having thereon at least one electrically controllable microheating element including at least a microheater portion with multiple electrodes connected to the microheater portion for forming a micropore in the user's skin. A nanofiber mat loaded with at least one antimicrobial material is arranged on the substrate such that it contacts the user's skin and encircles an opening of the micropore formed by the microheating element. ... Georgetown University

01/26/17 / #20170022562

Biomarkers and therapeutic targets for abnormal retinal pigment epithelium

The present invention relates to markers and therapeutic targets of abnormal retinal pigment epithelium (rpe).. . ... Georgetown University

01/12/17 / #20170011131

System and method for detecting, collecting, analyzing, and communicating event related information

A system and method involves detecting operational social disruptive events on a global scale, assigning disease event staging and warnings to express data in more simplistic terms, modeling data in conjunction with linguistics analysis to establish responsive actions, generating visualization and modeling capabilities for communicating information, and modeling disease propagation for containment and forecasting purposes.. . ... Georgetown University

01/12/17 / #20170007588

Small molecule inhibitors of xbp1 splicing

Small molecule inhibitors of xbp1 splicing by ire1α are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.. . ... Georgetown University

01/05/17 / #20170000746

Methods for treating heat stress and related compositions

Methods of treating, reducing, and/or preventing heat stress are provided. For example, provided is a method of treating or preventing heat stress in a subject comprising selecting a subject in need of heat stress treatment or prevention and administering an effective amount of one or more of astaxanthin and milk casein hydrolysate, or a derivative thereof to the subject. ... Georgetown University








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