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Guardant Health Inc patents


Recent patent applications related to Guardant Health Inc. Guardant Health Inc is listed as an Agent/Assignee. Note: Guardant Health Inc may have other listings under different names/spellings. We're not affiliated with Guardant Health Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "G" | Guardant Health Inc-related inventors


 new patent  Locked nucleic acids for capturing fusion genes

Provided herein is a method for enriching a sample for polynucleotides comprising a breakpoint of a fusion gene, comprising: a) contacting a probe set comprising a plurality of polynucleotide probes, each probe configured to specifically hybridize to a fusion gene, wherein the set comprises one or more high affinity polynucleotide probes (e.g., a polynucleotide comprising one or more locked nucleic acid nucleotides), with a mixture of polynucleotides under hybridization conditions to produce probe-captured polynucleotides; and b) isolating the probe-captured polynucleotides from the mixture, to produce a sample enriched with polynucleotides comprising breakpoint fragments of the fusion gene.. . ... Guardant Health Inc

Systems and methods to detect rare mutations and copy number variation

The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. ... Guardant Health Inc

Diagnostic methods

A method for analyzing a disease state of a subject includes characterizing the subject's genetic information at two or more time points or instances with a genetic analyzer, e.g., a deoxyribonucleic acid (dna) sequencer, and using the information from the two or more time points or instances to produce an adjusted test result in the characterization of the subject's genetic information.. . ... Guardant Health Inc

Systems and methods to detect rare mutations and copy number variation

The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. ... Guardant Health Inc

Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results

This disclosure provides, among other things, methods for generating and applying therapeutic interventions. The methods involve, for example, (a) sequencing polynucleotides from cancer cells from a subject; (b) identifying and quantifying somatic mutations in the polynucleotides; (c) developing a profile of tumor heterogeneity in the subject indicating the presence and relative quantity of a plurality of the somatic mutations in the polynucleotides, wherein different relative quantities indicates tumor heterogeneity; and (d) determining a therapeutic intervention for a cancer exhibiting the tumor heterogeneity, wherein the therapeutic intervention is effective against a cancer having the profile of tumor heterogeneity determined.. ... Guardant Health Inc

Methods to determine tumor gene copy number by analysis of cell-free dna

Methods are provided herein to improve automatic detection of copy number variation in nucleic acid samples. These methods provide improved approaches for determining baseline copy number of genetic loci within a sample, reduce variation due to features of genetic loci, sample preparation, and probe exhaustion.. ... Guardant Health Inc

Methods and applications of gene fusion detection in cell-free dna analysis

Systems and methods are disclosed for determining gene fusion by determining a fused read containing sequencing data of a portion of a fused chromosome dna molecule; determining a predetermined point on the genome with least one mapped portion of the fused read clipped at the predetermined point (a breakpoint); identifying two mapped read portions from two breakpoints (breakpoint pair) as a potential fusion candidate; creating one or more fusion sets based on breakpoint pairs and clustering the fusion sets into one or more fusion clusters; and identifying each fusion cluster meeting a predetermined criterion as a gene fusion.. . ... Guardant Health Inc

Locked nucleic acids for capturing fusion genes

Provided herein is a method for enriching a sample for polynucleotides comprising a breakpoint of a fusion gene, comprising: a) contacting a probe set comprising a plurality of polynucleotide probes, each probe configured to specifically hybridize to a fusion gene, wherein the set comprises one or more high affinity polynucleotide probes (e.g., a polynucleotide comprising one or more locked nucleic acid nucleotides), with a mixture of polynucleotides under hybridization conditions to produce probe-captured polynucleotides; and b) isolating the probe-captured polynucleotides from the mixture, to produce a sample enriched with polynucleotides comprising breakpoint fragments of the fusion gene.. . ... Guardant Health Inc

Systems and methods to detect rare mutations and copy number variation

The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. ... Guardant Health Inc

Systems and methods to detect rare mutations and copy number variation

The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. ... Guardant Health Inc

Machine learning for somatic single nucleotide variant detection in cell-free tumor nucleic acid sequencing applications

Systems and methods are disclosed to detect single-nucleotide variations (snvs) from somatic sources in a cell-free biological sample of a subject by generating training data with class labels; in computer memory, generating a machine learning unit comprising one output for each of adenine (a), cytosine (c), guanine (g), and thymine (t) calls; training the machine learning unit; and applying the machine learning unit to detect the snvs from somatic sources in the cell-free biological sample of the subject, wherein the cell-free biological sample comprises a mixture of nucleic acid molecules from somatic and germline sources.. . ... Guardant Health Inc

Identification of somatic mutations versus germline variants for cell-free dna variant calling applications

The present disclosure provides systems and methods to detect somatic or germline variants by providing a predetermined genomic dna (gdna) to an assay mixture, and capturing a sample of a subject's genetic information using a dna sequencer and detecting genetic variants from the genetic information. A mutation may then be classified as being from a germline source if gdna derived molecules have lengths inconsistent with those expected from cell-free dna (cfdna) derived molecules.. ... Guardant Health Inc








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