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Hakko Corporation patents


Recent patent applications related to Hakko Corporation. Hakko Corporation is listed as an Agent/Assignee. Note: Hakko Corporation may have other listings under different names/spellings. We're not affiliated with Hakko Corporation, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "H" | Hakko Corporation-related inventors


Therapeutic agent for a tumor comprising an ido inhibitor administered in combination with an antibody

The present invention provides a method for treating a tumor comprising administering an effective amount of an antibody which specifically binds to human cc chemokine receptor 4, human epidermal growth factor receptor 2, human cd20, or epidermal growth factor receptor, and an indoleamine 2,3-dioxygenase inhibitor to a human in need thereof, and the like.. . ... Hakko Corporation

Melting tool controller

A melting tool control apparatus comprises a drive mechanism, a melt processing assembly configured to perform a melt process, a receiving module that receives input of three-dimensional coordinate information of a first point where the melt process is to be performed and input of a position information indicating a position different from the first point, and a process control module configured to control the melt processing assembly to perform the melt process when the distal end is at the first point.. . ... Hakko Corporation

Antibody which specifically binds to human crth2

There is provided an anti-human crth2 antibody which has desired activity by recognizing and binding to a specific human crth2; the antibody fragment; dna which encodes the amino acid sequence of the antibody; a vector which comprises the dna; hybridomas and antibody producing cells which produce the antibody; a method of producing the antibody; a composition which comprises the antibody or the antibody fragment; a treatment method and a diagnostic method of an allergic disease, an autoimmune disease, a disease accompanied by at least one of increase and hyperergasia of eosinophils; a disease accompanied by at least one of increase and hyperergasia of th2 cells using the antibody or the antibody fragment; and a medicine and a diagnostic agent which comprise the antibody or the antibody fragment.. . ... Hakko Corporation

Methods of treating patients suffering from movement disorders

The present invention is directed to methods of treating movement disorders by administering an effective amount of one or more adenosine a2a receptor antagonists to a patient in need thereof. The present invention also provides methods of decreasing the adverse effects of l-dopa in patients receiving l-dopa therapy in the treatment of parkinson's disease. ... Hakko Corporation

Antisense oligonucleotide inhibiting ß2gpi expression

. . The present invention aims to provide a novel nucleic acid capable of suppressing expression of β2gpi, as well as a pharmaceutical composition for the prophylaxis or treatment of diseases associated with β2gpi expression. The present invention solves the above-mentioned problem by providing an antisense oligonucleotide having a β2gpi expression suppressive activity, a pharmaceutical composition containing the antisense oligonucleotide, and a prophylactic or therapeutic drug for autoimmune diseases including aps, sle and the like, and thrombosis in hemodialysis that contains the antisense oligonucleotide and suppresses β2gpi expression.. ... Hakko Corporation

Soldering apparatus and method

A soldering apparatus and method involves capturing an image of a soldering operation, and storing image data in association with that particular soldering operation. A soldering tool that is used to perform the soldering operation has a position during the soldering operation, and the image data could also be stored in association with data for that particular position. ... Hakko Corporation

Controller and a control method for a hot air blower

A controller and a control method for a hot air blower used in the field of solder reworking. The controller allows a user to change the control parameters effectively while using the hot air blower.. ... Hakko Corporation

ß2gpi gene expression-suppressing nucleic acid conjugate

The present invention provides a nucleic acid conjugate comprising: a double-stranded nucleic acid consisting of a sense strand and an antisense strand and comprising a duplex region of at least 11 base pairs; and a ligand part, wherein an oligonucleotide with a strand length of 17 to 30 nucleotides in the antisense strand is complementary to a target β2gpi mrna sequence, and the 3′ end or 5′ end of the sense strand has a ligand part represented by following formula (i), formula (ii), formula (iii), formula (iv) or formula (v).. . ... Hakko Corporation

Method for purifying mitomycin c

Provided are a method for purifying mitomycin c, comprising a step of recrystallizing crude mitomycin c crystals using a high-purity methanol; mitomycin c obtainable by the method; and. . ... Hakko Corporation

Method for producing alpha-form crystal of reduced glutathione, and method for storing said crystal

The invention provides a method of efficiently and stably producing α-form crystal of reduced glutathione, and a preservation method thereof. According to the invention, development of β-form crystal and/or transition to β-form crystal of reduced glutathione are suppressed by the coexistence of at least one kind of compound selected from the group of aliphatic amino acid, sulfur-containing amino acid, aromatic amino acid, an analogous compound and dipeptide, as a habit modifier, during production and preservation of an aqueous solution or α-form crystal of reduced glutathione.. ... Hakko Corporation

Vacuum pick-up confirmation system

The present invention defines a tool including a heating device including a method and apparatus to allow the user to check whether, or be notified when, the soldered electronic component is completely removed from a substrate after the solder is sufficiently melted.. . ... Hakko Corporation

Therapeutic agent and therapeutic method for pulmonary hypertension

The present invention relates to a therapeutic agent for pulmonary hypertension comprising an interleukin-5 receptor (hereinafter, abbreviated to “il-5r”)-inhibiting compound and therapeutic method therefor. More specifically, the present invention relates to a therapeutic agent for pulmonary hypertension comprising an antibody or an antibody fragment capable of specifically binding to the extracellular region of il-5r and a therapeutic method therefor.. ... Hakko Corporation

Ink supply tube

An ink supply tube of the present invention comprising an inner layer to come into contact with ink, a middle layer having at least three layers, and an outer layer, wherein the middle layer includes a first middle layer, a second middle layer, and a third middle layer, the inner layer comprises one of an ethylene-tetrafluoroethylene copolymer resin, a tetrafluoroethylene-perfluoroalkoxy alkane copolymer resin, and a modified perfluoroalkoxy-based resin, each having a solvent resistance, an oxygen barrier property, and a low moisture permeability, the first middle layer comprises a polyamide resin having a fusibility with the inner layer or the second middle layer, the second middle layer comprises an ethylene-vinyl alcohol copolymer resin having an oxygen barrier property, the third middle layer comprises an adhesive polyolefin resin having a fusibility with the second middle layer or the outer layer, and having a low moisture permeability, and the outer layer comprises a thermoplastic resin or elastomer. Accordingly, an ink supply tube for an inkjet printer is provided that has a more excellent oxygen barrier property and a more excellent low moisture permeability in addition to an excellent solvent resistance and an excellent flexibility.. ... Hakko Corporation

Therapeutic composition containing antithrombin gamma

The present invention pertains to a therapeutic composition comprising antithrombin gamma for diffuse intravascular coagulation or disseminated intravascular coagulation involving a decrease of antithrombin, or for thrombophilia due to congenital antithrombin deficiency.. . ... Hakko Corporation

04/05/18 / #20180094025

Crystal of reduced glutathione

The present invention provides a crystal of reduced glutathione that is stable, and is easy to process, and a method for producing the crystal. According to the present invention, a crystal of a metal salt of reduced glutathione is produced by suspending an amorphous solid of a metal salt of reduced glutathione in a hydrophobic organic solvent, and adding water to the resulting suspension to precipitate a crystal of a metal salt of reduced glutathione.. ... Hakko Corporation

03/29/18 / #20180085373

Therapeutic and/or prophylactic agent for lewy body disease

The present invention provides a therapeutic and/or prophylactic agent and the like, comprising istradefylline as an active ingredient, for lewy body disease (for example, parkinson's disease dementia, diffuse lewy body disease, dementia with lewy bodies, movement disorder associated with lewy body disease and the like).. . ... Hakko Corporation

03/15/18 / #20180072612

Glass lining, method for manufacturing glass lining and method for cleaning glass-lined articles

A glass lining that has an excellent balance between a hydrophilic property and a hydrophobic property on its surface, that has less adhesion of dirt than a typical gl since having an excellent stain-proof property against both oily stains and aqueous stains, and that can maintain the stain-proof property and the self-cleaning performance for a long time after the glass lining is cleaned, leading to excellent cleaning performance and low dirt-adhesion. The glass lining includes a lining and a conductive inorganic compound contained in the lining. ... Hakko Corporation

02/15/18 / #20180044678

Double-stranded ribonucleic acid for adjuvants

The invention provides a double-stranded ribonucleic acid (dsrna) having a chain length suitable for simultaneously showing low toxicity and high function in the use of an adjuvant and the like, and resisting variation of chain length even when subjected to a heating and cooling treatment, or a salt thereof; an immune potentiator, adjuvant, pharmaceutical product and the like containing the dsrna and the like; and a production method of such dsrna and the like. The invention is characterized in that the weight average chain length of two or more single-stranded ribonucleic acids (ssrnas) constituting the first chain constituting dsrna is not more than ½ of the weight average chain length of one ssrna constituting the second chain.. ... Hakko Corporation

02/15/18 / #20180042910

Therapeutic agent for frontal lobe dysfunction

The present invention provides a therapeutic and/or prophylactic agent for, for example, frontal lobe dysfunction (for example, cognitive impairment (for example, cognitive impairment in parkinson's disease, cognitive impairment caused by chronic stress, dementia with lewy bodies, progressive supranuclear palsy, frontotemporal dementia and the like) and the like), lewy body disease (for example, cognitive impairment in parkinson's disease, diffuse lewy body disease, dementia with lewy bodies, movement disorder associated with lewy body disease and the like) and the like, which contains a compound represented by the formula (i) or a pharmaceutically acceptable salt thereof as an active ingredient.. . ... Hakko Corporation

02/08/18 / #20180036819

Cleaning pad assembly

The invention details the designs of cleaning pad assemblies for use with heating tools including for example soldering cartridges and soldering irons. The cleaning pads of the assembly are designed to effectively remove and clean the solder from heating tools during and at the end of soldering operations, and allow the collection of the removed solder.. ... Hakko Corporation

02/01/18 / #20180030146

Human cdr-grafted antibody and antibody fragment thereof

A human cdr-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human cc chemokine receptor 4 (ccr4) but does not react with a human blood platelet; a human cdr-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of ccr4 and has a cytotoxic activity against a ccr4-expressing cell; and a medicament, a therapeutic agent or a diagnostic agent comprising at least one of the antibodies and the antibody fragments thereof as an active ingredient.. . ... Hakko Corporation

01/18/18 / #20180016346

Bispecific antibody binding to trailr2 and psma

The present invention is related to a bispecific antibody or an antibody fragment thereof comprising an antigen binding domain that binds to a trailr2, and an antigen binding domain that binds to a psma; a nucleic acid comprising a nucleotide sequence that encodes the antibody or the antibody fragment thereof; a recombinant vector comprising the nucleic acid; a transformant comprising the recombinant vector; a method for producing the bispecific antibody or the antibody fragment thereof by using the transformant; and a reagent for detection or measurement, a diagnostic agent, and a therapeutic agent, each of which comprises the bispecific antibody or the antibody fragment thereof.. . ... Hakko Corporation

01/04/18 / #20180002364

Crystal of ammonium n-acetylneuraminate anhydrate, and process for producing same

. . According to the present invention, a crystal of ammonium n-acetylneuraminate anhydrate, and a process for producing a crystal of ammonium n-acetylneuraminate anhydrate, comprising adding or adding dropwise a solvent selected from the group consisting of alcohols and ketones to an aqueous n-acetylneuraminic acid solution containing an ammonium-containing compound and having a ph of 3.0 to 9.0 to precipitate a crystal of ammonium n-acetylneuraminate anhydrate, and collecting the crystal of ammonium n-acetylneuraminate anhydrate from the aqueous solution, can be provided.. . ... Hakko Corporation

12/21/17 / #20170362323

Heterodimer protein composition

According to the present invention, a heterodimer protein composition that is composed of a first polypeptide comprising an immunoglobulin heavy chain constant region and a second polypeptide comprising cl-fc prepared by fusion of an immunoglobulin light chain constant region (cl) and fc region, and also has a deletion or substitution of cys residues involved in disulfide bonds between cl and ch1, a purification method of the protein composition thereof, a preparation method of the protein composition thereof, a dna and a vector encoding the protein composition thereof are provided. . ... Hakko Corporation

12/21/17 / #20170360733

Aging inhibitor

An object of the present invention is to provide a senescence retarding agent that delays the onset of senescence symptoms and extends longevity, and is superior in safety. The senescence retarding agent of the present invention that achieves the object is characterized by containing a plant fermentation product as an active ingredient, the plant fermentation product being a mixture of the following: (a) a koji mold-fermented product of one or more kinds of beans and/or cereals selected from the group consisting of barley, black soybean, red rice, black rice, adzuki bean, adlay, japanese millet, foxtail millet, and millet; (b) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of fruits selected from the group consisting of mikan (mandarin orange), grape, apple, yama-budo (crimson glory grape), peach, kaki (japanese persimmon), papaya, nashi (japanese pear), watermelon, ume (japanese apricot), fig, karin (chinese quince), pumpkin, kumquat, yuzu (chinese lemon), loquat, apricot, jujube, chestnut, matatabi (silvervine), and sumomo (japanese plum); (c) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of root crops and/or potatoes selected from the group consisting of murasaki-imo (purple sweet potato), kikuimo (jerusalem artichoke), carrot, onion, satsuma-imo (sweet potato), satoimo (taro), jinenzyo (japanese yam), daikon (japanese radish), akakabu (red turnip), gobo (burdock root), renkon (lotus root), yacon, yuri-ne (lily bulb), kuwai (arrowhead), ginger, garlic, and turmeric; (d) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of flowers and/or leaf vegetables selected from the group consisting of cabbage, shiso (perilla), mulberry leaves, dokudami (korean houttuynia), yomogi (wormwood), kumazasa (kuma bamboo grass), and dandelion; (e) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of seaweeds selected from the group consisting of kombu (sea tangle), wakame (undaria pinnatifida), and mozuku (nemacystus decipiens); (f) a yeast- and/or lactic acid bacterium-fermented product of one or more kinds of seeds selected from the group consisting of black sesame seeds, walnuts, and ginkgo nuts; and (g) a yeast- and/or lactic acid bacterium-fermented product of one or two kinds of mushrooms selected from the group consisting of maitake (grifola frondosa) and shiitake (lentinus edodes).. ... Hakko Corporation

12/14/17 / #20170354673

Oligonucleotide having non-natural nucleotide at 5'-terminal thereof

An oligonucleotide having a nucleotide residue or a nucleoside residue represented by formula (i) {wherein x1 is an oxygen atom or the like, r1 is formula (iia) (wherein r5a is halogen or the like, and r6a is a hydrogen atom or the like), formula (iva) (wherein y3a is a nitrogen atom or the like, and y4a is ch or the like), or the like, r2 is a hydrogen atom, hydroxy, halogen, or optionally substituted lower alkoxy, and r3 is a hydrogen atom or the like, or formula (vi) (wherein n2 is 1, 2 or 3)} at the 5′ end thereof, wherein the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue through the oxygen atom at position 3, is provided.. . ... Hakko Corporation

11/23/17 / #20170336098

Hot air nozzle and its production method

. . The invention is directed to a nozzle for a hot air device used in the electronic assembly industry to melt solder or heat shrink-wrap insulators. The nozzle provides a uniform temperature environment and suppresses the occurrence of local excess heating.. ... Hakko Corporation

11/23/17 / #20170335016

Stable multivalent antibody

The present invention relates to a multivalent antibody comprising multiple heavy chain variable regions of antibody linked to each other via a linker comprising an amino acid sequence encoding an immunoglobulin domain or a fragment thereof.. . ... Hakko Corporation

10/05/17 / #20170281582

Enhancer for eating activity and/or gastrointestinal activity

An agent for secreting ghrelin, comprising ornithine or a salt thereof as an active ingredient, an agent for enhancing eating activity, comprising ornithine or a salt thereof as an active ingredient, and an agent for enhancing gastrointestinal activity, comprising ornithine or a salt thereof as an active ingredient.. . ... Hakko Corporation

09/28/17 / #20170275296

Therapeutic agent for motor disorders

Provided are an agent for the treatment and/or prophylaxis of a movement disorder, the agent for the treatment and/or prophylaxis wherein the movement disorder is extrapyramidal syndrome, the agent for the treatment and/or prophylaxis wherein the movement disorder is bradykinesia, gait disturbance, dystonia, dyskinesia or tardive dyskinesia, the agent for the treatment and/or prophylaxis wherein the movement disorder is a side effect of l-dopa and/or dopamine agonist therapy, and the like, each containing a thiazole derivative represented by the formula (i) wherein r1 represents aryl and the like, and r2 represents pyridyl or the like, or a pharmaceutically acceptable salt thereof as an active ingredient.. . ... Hakko Corporation

09/21/17 / #20170266255

Pharmaceutical composition for treating bone diseases which comprises protein comprising frizzled1, frizzled2 or frizzled7 extracellular cysteine-rich domain

This invention relates to a pharmaceutical composition for treatment of a bone disease comprising, as an active ingredient, a protein comprising an extracellular cysteine-rich domain, which is from the frizzled receptor selected from the group consisting of mammalian animal-derived frizzled 1, frizzled 2, and frizzled 7 and has activity of increasing bone mass, bone density, and/or bone strength, or a mutant of such domain having sequence identity of 85% or higher to the amino acid sequence of the domain and having activity of increasing bone mass, bone density, and/or bone strength, or a vector comprising a nucleic acid encoding the protein.. . ... Hakko Corporation

09/07/17 / #20170253627

Crystal of alkali metal n-acetylneuraminate anhydrate, and process for producing same

According to the present invention, a crystal of an alkali metal n-acetylneuraminate anhydrate, and a process for producing a crystal of an alkali metal n-acetylneuraminate anhydrate, comprising adding or adding dropwise a solvent selected from the group consisting of alcohols and ketones to an aqueous n-acetylneuraminic acid solution containing an alkali metal-containing compound and having a ph of 3.0 to 9.0 to precipitate a crystal of an alkali metal n-acetylneuraminate anhydrate, and collecting the crystal of an alkali metal n-acetylneuraminate anhydrate from the aqueous solution, can be provided.. . ... Hakko Corporation

08/31/17 / #20170247701

Nucleic acid capable of inhibiting expression of beta-2gpi

The present invention provides a nucleic acid having activity to suppress expression of β2gpi, a pharmaceutical composition comprising the nucleic acid, and a prophylactic or therapeutic drug containing the nucleic acid for autoimmune diseases such as aps, sle and the like and thrombosis in hemodialysis.. . ... Hakko Corporation

08/31/17 / #20170247700

Nucleic acid capable of inhibiting expression of beta-2gpi

The present invention provides a nucleic acid having activity to suppress expression of β2gpi, a pharmaceutical composition comprising the nucleic acid, and a prophylactic or therapeutic drug containing the nucleic acid for autoimmune diseases such as aps, sle and the like and thrombosis in hemodialysis.. . ... Hakko Corporation

08/31/17 / #20170247449

Therapeutic method and medicament for cancer patients by folr1-targeting drug and an antagonist for folic acid metabolism

The invention provides a method for treating a cancer with a human folr1-targeting drug by increasing an expression of folate receptor α (hereinafter abbreviated to folr1) by using an antagonist for folic acid metabolism, a medicament for a cancer containing a human folr1-targeting drug for increasing an expression of folr1 by using an antagonist for folic acid metabolism and a method for enhancing a therapeutic effect of a human folr1-targeting drug by increasing an expression of folr1 in a cancer cell by using an antagonist for folic acid metabolism. For example, the invention provides a more effective therapeutic method using an antagonist for folic acid metabolism with a human folr1-targeting drug, for cancer patients in which an expression level of folr1 is low and in which an anti-tumor activity of the human folr1-targeting drug is not exhibited sufficiently or for cancer patients in which a treatment of a cancer expressing folr1 is to be further enhanced.. ... Hakko Corporation

08/24/17 / #20170240647

Method of modulating the activity of functional immune molecules

The invention relates to a method for controlling the activity of an immunologically functional molecule, such as an antibody, a protein, a peptide or the like, an agent of promoting the activity of an immunologically functional molecule, and an immunologically functional molecule having the promoted activity.. . ... Hakko Corporation

08/17/17 / #20170238409

Printed board and method for manufacturing same

The object of the present invention is to provide a printed circuit board that improves the heat radiating effect as the entire printed circuit board and a manufacturing method for such a printed circuit board. A printed circuit board includes a base member having two main surfaces, at least one heat-radiating conductor layer formed on at least one of the main surfaces of the two main surfaces of the base member and a solder resist layer formed on a surface of the heat-radiating conductor layer, and in this printed circuit board, the heat-radiating conductor layer has two main surfaces and at least one side face, the heat-radiating conductor layer has its one main surface of the two main surfaces made in planar contact with the main surface of the base member, the solder resist layer further has an etching liquid resistance, and is formed on the other main surface of the two main surfaces of the heat-radiating conductor layer, with the side face of the heat-radiating conductor layer being exposed, and the heat-radiating conductor layer and the solder resist layer are allowed to form a laminate 24 having a substantially convex shape with an appropriate height.. ... Hakko Corporation

08/03/17 / #20170215911

Endoscopic snare

. . . . There is provided an endoscopic snare including: a flexible sheath 1; a cable 2 configured to slide in the sheath; a snare loop 3 connected to the cable 2, and projecting from or retracting into the sheath 1; a distal end tip 4 disposed in a distal end part of the sheath and retaining the snare loop 3; and a hand operating part for operating the snare loop 3 via the cable 2. One end of the snare loop 3 is attached to the distal end tip and the other end of the snare loop 3 is attached to a distal end of the cable. ... Hakko Corporation

07/20/17 / #20170204189

Therapeutic method and medicament for htlv-1 associated myelopathy

The object of the present invention is to provide a new therapeutic method and a new therapeutic agent that are different from known therapeutic medicines for human t cell leukemia virus type-1 (also known as human t lymphotropic virus type-1) associated myelopathy (ham) patients and asymptomatic htlv-1 carriers. The present invention relates to a therapeutic method and a therapeutic agent for human t cell leukemia virus type-1 (htlv-1) associated myelopathy (ham) patients and asymptomatic htlv-1 carriers (acs), which is characterized by reducing htlv-1 virus-infected cells using an anti-human cc-chemokine receptor 4 (ccr4) antibody.. ... Hakko Corporation

07/20/17 / #20170204056

Process for producing 7-dehydrocholesterol and vitamin d3

According to the present invention, there can be provided a process for producing 7-dehydrocholesterol (7dhc), comprising culturing, in a medium, a 7dhc-producing labyrinthulea microorganism in which sterol 24-c-methyltransferase activity is reduced or lost as compared to a parent strain, allowing 7dhc to be produced and accumulated in the culture, and collecting the 7dhc from the culture; and a process for producing vitamin d3, comprising irradiating, with ultraviolet light, 7-dehydrocholesterol produced by the production process.. . ... Hakko Corporation

07/13/17 / #20170198262

Culture medium and culturing method for anchorage-dependent cells, cell composition including stem cells and/or differentiated cells derived from stem cells, and production method for cell composition

. . As a technique capable of culturing anchorage-dependent cells without using an anchorage, provided is a medium for anchorage-dependent cells, which comprises mfg-e8 (milk fat globule-egf factor 8) or a fragment of the protein. This medium can promote adhesion of anchorage-dependent cells in the absence of an anchorage, enables the survival and proliferation (colony formation) of the cells, and further, also enables the subsequent differentiation if the anchorage-dependent cells are stem cells.. ... Hakko Corporation

07/13/17 / #20170196872

Methods of treating patients suffering from movement disorders

The present invention is directed to methods of treating movement disorders by administering an effective amount of one or more adenosine a2a receptor antagonists to a patient in need thereof. The present invention also provides methods of decreasing the adverse effects of l-dopa in patients receiving l-dopa therapy in the treatment of parkinson's disease. ... Hakko Corporation

07/06/17 / #20170190781

Anti-death receptor 3 (dr3) antagonistic antibodies with reduced agonistic activity

According to the present invention, anti-death receptor 3 (dr3) antagonistic igg antibodies and antibody fragments thereof, wherein the antibodies and the antibody fragments thereof display a decreased agonistic activity or no agonistic activity for dr3 through their binding, an antibody compositions and an antibody fragment compositions comprising them, a nucleotide sequence encoding the antibody or the antibody fragment, a vector comprising the nucleotide sequences, an amino acid sequences of the antibodies or the antibody fragments, a method of producing the antibodies or the antibody fragments thereof, and a method of decreasing the agonistic potency of an antibody against dr3 through its binding, are provided.. . ... Hakko Corporation

07/06/17 / #20170189467

Methods and compositions for enhancement of ability to concentrate

A composition for enhancement of ability to concentrate and method of improving ability to concentrate using alanylglutamine or a salt of alanylglutamine as an active ingredient.. . ... Hakko Corporation

06/29/17 / #20170182576

Holding stand

A holding stand for a heating tool such as a soldering or de-soldering device. The holding stand has a rotary member for securing the heating tool and an assembly for moving and positioning the rotary member with the heating tool in any of three axis.. ... Hakko Corporation

06/15/17 / #20170166650

Antibody variants composition

Among n-glycoside-linked sugar chains which are bound to the fc region of an antibody, sugar chains which are bound to asn at position 297 relates to the activity and stability of the antibody in blood, but there is a possibility that extra sugar chains bound to the amino acid residues at positions other than 297 have influences upon the antibody constant region-mediated activity and a possibility of causing a problem of uniformity as a therapeutic antibody preparation. Accordingly, among n-glycoside-linked sugar chains which bind to the fc region of the antibody, a method for controlling extra sugar chains which are bound to asn residues at positions other than position 297 according to the eu index is required. ... Hakko Corporation

06/15/17 / #20170165771

Support stand for heating tools

A support stand for a soldering or de-soldering handheld tool comprises a base and a cradle for supporting the handheld tool when it is not in use that protects the surrounding work area and accommodates user preferences.. . ... Hakko Corporation

05/04/17 / #20170121415

Antibody which specifically binds to human crth2

There is provided an anti-human crth2 antibody which has desired activity by recognizing and binding to a specific human crth2; the antibody fragment; dna which encodes the amino acid sequence of the antibody; a vector which comprises the dna; hybridomas and antibody producing cells which produce the antibody; a method of producing the antibody; a composition which comprises the antibody or the antibody fragment; a treatment method and a diagnostic method of an allergic disease, an autoimmune disease, a disease accompanied by at least one of increase and hyperergasia of eosinophils; a disease accompanied by at least one of increase and hyperergasia of th2 cells using the antibody or the antibody fragment; and a medicine and a diagnostic agent which comprise the antibody or the antibody fragment.. . ... Hakko Corporation

04/13/17 / #20170099814

Human artificial chromosome containing human antibody lambda light chain gene and non-human animal containing the human artificial chromosome capable of genetic transmission

The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 mb to about 1 mb region containing an antibody λ light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the nonhuman animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome.. ... Hakko Corporation

03/30/17 / #20170088627

Combination of an anti-ccr4 antibody and a 4-1bb agonist for treating cancer

The present disclosure describes combination therapies comprising an antibody which specifically binds to human ccr4 and a selective 4-1bb agonist, and the use of the combination therapies for the treatment of cancer.. . ... Hakko Corporation

03/23/17 / #20170081667

Nucleic acid that inhibits expression of irf5

The present invention provides a nucleic acid having activity to suppress expression of irf5, a pharmaceutical composition comprising the nucleic acid, and a prophylactic or therapeutic drug containing the nucleic acid for autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis and the like.. . ... Hakko Corporation

03/23/17 / #20170081417

Human monoclonal antibody human cd134 (ox40) and methods of making and using same

The invention provides antibodies that specifically bind to ox40 (cd134), referred to as ox40 antibodies, anti-ox40 or anti-ox40 antibodies. Invention antibodies that specifically bind to ox40 include mammalian (human, primate, etc.), humanized and chimeric anti-ox40 antibodies. ... Hakko Corporation

02/23/17 / #20170050251

Heating cartridge and heating tool with same

A heater cartridge comprises a heater contained within a distal section of housing pipe near a working portion, such as soldering iron tip or a blade for stripping wire. The wall thickness of the housing pipe is generally thin to limit heat transfer to a proximal section of the housing pipe near where a user's hand would be normally located. ... Hakko Corporation

02/23/17 / #20170049796

Administration of citicoline to improve cognitive performance, attentional performance, and motor function

A method of improving both motor function and cognitive function of healthy human subjects through administration of citicoline or its salt in high dosage or low dosage for a period of time, resulting in improved motor function and cognitive function.. . ... Hakko Corporation

02/16/17 / #20170043039

Method for measuring toxicity of human csf

. . The problem is to provide a method that can quickly and efficiently evaluate the toxicity of human cerebrospinal fluid (csf) with small amounts of human csf. The problem is solved by a method comprising administering human csf into the cerebral ventricle of a rodent such as a mouse, and evaluating the cognitive function of the rodent by using a behavioral pharmacological technique.. ... Hakko Corporation

02/16/17 / #20170042962

Agent for preventing or ameliorating vascular endothelial malfunction

An agent for preventing or ameliorating vascular endothelial malfunction and arteriosclerosis-related symptoms caused by the progress of vascular endothelial malfunction (e.g., ischemic diseases such as myocardial infarction, angina, and peripheral artery occlusion) or low blood flow-related symptoms (e.g., stiff shoulders, excessive sensitivity to cold, swelling, erectile dysfunction, rough skin and decrease in exercise performance due to skeletal muscle hypoactivity), which has an improved no production enhancing effect is provided. A no production enhancer comprising citrulline or a salt thereof and glutathione or a salt thereof as active ingredients. ... Hakko Corporation

02/02/17 / #20170028497

Heater sensor complex with high thermal capacity

The invention is directed to designs for heater-sensor sub-assemblies for soldering cartridges and de-soldering cartridges for soldering systems. The designs provide a high thermal capacity and accurate tip temperature sensing and control features. ... Hakko Corporation








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