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Health Research Inc patents


Recent patent applications related to Health Research Inc. Health Research Inc is listed as an Agent/Assignee. Note: Health Research Inc may have other listings under different names/spellings. We're not affiliated with Health Research Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "H" | Health Research Inc-related inventors


Biomarkers for prostate cancer

The disclosure provides methods of using biomarkers to improve diagnosis of forms of prostate. The method includes testing a biological sample from an individual for a interleukin-8 (il-8), tumor necrosis factor alpha (tnf-α) and soluble tumor necrosis factor-α receptor 1 (stnfr1), and may further include testing for prostate serum antigen (psa). ... Health Research Inc

Method and composition for treatment of hair loss

A method of treating a hair loss condition, comprising administering a notch signaling pathway activator to a subject in need thereof.. . ... Health Research Inc

Method for genotyping mycobacterium tuberculosis

The present application provides a method for genotyping m. Tuberculosis, comprising obtaining amplifying and obtaining a first dna fragment from a dna sample by using one or more primer sets selected from the group consisting of primer sets 1 to 25 (seq id nos. ... Health Research Inc

Heterocyclic compounds and use thereof

Heterocyclic compounds of formula (i) shown herein. Also disclosed is a pharmaceutical composition containing one of the heterocyclic compounds. ... Health Research Inc

System and method for delivering dose light to tissue

A system and method for interstitial photodynamic light therapy (i-pdt) of a tissue. A plurality of light-transmitting catheters (ltcs) are provided and placed in the tissue according to a pre-determined treatment plan, wherein an ltc includes a first treatment fiber disposed therethrough, and an ltc includes a dosimetry fiber disposed therethrough. ... Health Research Inc

System and method for administering light therapy to curved and large surfaces

A system and method are disclosed that use a flexible guide (flap) and a scanning method to control the delivery of light dose to a treatment area. This approach overcomes the non-reliable delivery of light dose with a flap that conforms to the target area. ... Health Research Inc

Diagnostic test for alzheimer's disease based on identification of a proteolytic pathway

A method for detecting circulating levels of beta amyloid peptides in an individual by administration of one or more inhibitors of an extracellular proteolytic pathway in blood and detection of the beta amyloid peptides in the blood or a fraction thereof. An example of an inhibitor is an anticoagulant. ... Health Research Inc

Combination therapy for hepatocellular carcinoma

Provided are methods and compositions for a combination therapy for liver disorders such as hepatocellular carcinoma. Also provided is a method for determining the effectiveness of therapy involving tyrosine kinase inhibitors such as sorafenib. ... Health Research Inc

Method of stimulating tlr9-activated immune response

A method of stimulating a tlr9-activated immune response or enhancing a tlr9-activated immune response to an antigen is disclosed herein. Tlr9 is the cellular receptor for cpg-odn, and current developed cpg-odn has low activity to rabbit tlr9. ... Health Research Inc

Enrichment of cd16+ monocytes to improve dendritic cell vaccine quality

Compositions and methods are provided for converting the predominant circulating classical monocytes to a non-classical and/or intermediate monocyte phenotype through cytokine stimulation via, for example, macrophage colony-stimulating factor. Once cultured into dendritic cells, these non-classical and/or intermediate monocyte derived cells have increased costimulatory molecule expression, which leads to improved immune and clinical responses in cancer patients receiving dendritic cell vaccination and other immunotherapies. ... Health Research Inc

Immune modulator for immunotherapy and vaccine formulation

A recombinant flagrp170 protein and pharmaceutical compositions comprising a flagrp170 protein and related molecules encoding same, and cells presenting such a protein are provided. The flagrp170 protein comprises an nf-κb-activating domain of flagellin and an atp-binding domain truncated grp170. ... Health Research Inc

Prevention of psychotic disorders and/or treatment of psychotic symptoms

The present invention relates to methods of preventing a psychotic disorder in a subject in need of intervention including administering to the subject a composition including epa (eicosapentanoic acid) and dha (docosahexaenoic acid). Methods of treating pre-psychotic symptoms in a subject, including administering to the subject a composition including epa and dha are also included.. ... Health Research Inc

Use of atpenin to activate innate immunity

Provided is a method for inducing innate apolipoprotein b editing catalytic protein (apobec) driven c>u rna deamination of rna in a cell comprising contacting the cell with an effective amount of atpenin a5 with or without interferon. Specifically, apobec3a is a cytidine deaminase enzyme that edits rna transcripts of hundreds of cellular genes upon stimulation of innate immune cells by low oxygen tension (hypoxia) or antiviral factor interferon. ... Health Research Inc

Jejunostomy tube and method

A jejunostomy tube (“j-tube”) is presented. The j-tube is amenable for placement via total laparoscopic approach, without the need for any percutaneous, endoscopic, or open operative assistance. ... Health Research Inc

03/15/18 / #20180072793

Apobec3a cytidine deaminase induced rna editing

Provided are methods for identifying agents which can induce or inhibit c>u deamination in rna driven by apolipoprotein b editing catalytic proteins. The method comprises contacting apobec3a or apobec3g with a suitable rna substrate and determining the extent of c>u deamination under conditions which induce apobec driven c>u deamination.. ... Health Research Inc

03/15/18 / #20180070847

Improved measurement of cortical excitability

The present invention includes a responsive neural stimulator having electrodes, a filter, a processor, a recording medium, an extractor for extracting instantaneous voltage amplitudes of biased oscillatory activity with asymmetrically distributed peak/trough amplitudes, and a neural stimulator connected to the processor configured to apply neural stimulation via the neural stimulator when a predetermined state of neuronal excitability is detected, a state of relatively higher neuronal excitability corresponding to a relatively lower instantaneous voltage amplitude extracted by the extractor. Also provided is a system for providing neurofeedback including electrodes, a filter, a processor, a recording medium, an extractor for extracting instantaneous voltage amplitudes of biased oscillatory activity with asymmetrically distributed peak/trough amplitudes, and an output device configured to communicate changes in, increases in, decreases in, or maintenance of instantaneous voltage amplitudes, or any combination, to a participant in a neurofeedback session.. ... Health Research Inc

03/01/18 / #20180057602

Combination therapy of cancer with anti-endoglin antibodies and anti-vegf agents

The present application relates to compositions of chimeric anti-endoglin antibodies and anti-vegf agents. Another aspect relates to the use of chimeric anti-endoglin antibodies and bevacizumab. ... Health Research Inc

02/22/18 / #20180051084

Combination of beta-adrenergic receptor antagonists and check point inhibitors for improved efficacy against cancer

Provided are methods for prophylaxis and/or therapy of cancer that include administering to an individual in need thereof an effective amount of a β-blocker and an immune checkpoint inhibitor such that growth of cancer in the individual is inhibited. Patients include those diagnosed with or at risk for a wide variety of cancer types. ... Health Research Inc

01/11/18 / #20180010133

Method of producing exosomes from stem cells and use thereof

. . A method of producing induced exosomes, the method comprising: contacting an isolated population of stem cells with an amount of a prostaglandin e receptor 4 (ep4) antagonist effective for inducing release of exosomes, whereby induced exosomes are released from the stem cells, and isolating the induced exosomes.. . ... Health Research Inc

01/11/18 / #20180009786

Heterocyclic compounds and use thereof

Heterocyclic compounds of formula (i) shown herein. Also disclosed are pharmaceutical compositions containing the heterocyclic compounds and methods of using the heterocyclic compounds to mobilize hematopoietic stem cells and endothelial progenitor cells into the peripheral circulation. ... Health Research Inc

01/11/18 / #20180008713

Sorbitan polyester conjugates for stabilizing water-in-oil emulsions and delivering controlled release of bioactive agents

A composition in a water-in-oil-in-water (w/o/w) emulsion is disclosed. The composition comprises: (a) a continuous aqueous phase, comprising h2o; (b) an oil phase or an oil shell, dispersed in the continuous aqueous phase; and (c) a hydrophilic polymer, stabilizing an interface between the continuous aqueous phase and the oil phase or the oil shell to form the water-in-oil-in-water (w/o/w) emulsion. ... Health Research Inc

12/28/17 / #20170368159

Lipidated streptococcus pneumoniae antigen compositions, methods of preparation and use

There are provided compositions and methods for prevention or treatment of streptococcus pneumoniae (sp)-associated diseases. More specifically, there are provided recombinant lipidated fusion proteins comprising pneumococcal surface antigen a (psaa), the recombinant lipidated fusion proteins comprising, from n-terminus to c-terminus, the n-terminal native lipid signal peptide of psaa and the c-terminal structural gene for psaa. ... Health Research Inc

11/30/17 / #20170343557

Use of 5-methoxytryptophan as diagnostic agent of inflammatory diseases

A diagnostic method for inflammatory diseases, and the diagnostic kit used in the method. The diagnostic method includes the use of a novel tryptophan metabolite, 5-methoxytryptophan (5-mtp), as a diagnostic biomarker of inflammation. ... Health Research Inc

10/26/17 / #20170306000

Method for determining deletions in hbv pre-s2 region

A method of detecting pre-s2 deletion mutant lhbs is disclosed herein. The method comprises incubating a biological sample with a first antibody to captured hbs proteins; detecting the lhbs and wt lhbs bound to the immobilized first antibody, respectively; and calculating the amount of the pre-s2 deletion mutant lhbs protein by subtracting the amount of the wt lhbs protein from that of the lhbs protein. ... Health Research Inc

10/05/17 / #20170281190

Pressurized anatomical compressor for kidney device

A surgical apparatus has connected strips that are configured to surround an organ, such as a kidney. The surgical apparatus at least partially mechanically occludes fluid flow into, out of or within part of the organ. ... Health Research Inc

09/14/17 / #20170258896

Endotoxin nanovesicles: hydrophilic gold nanodots control lipopolysaccharide assembly for modulating immunological responses

An endotoxin nanovesicle for enhancing type 1 t helper cell-induced immunological responses is disclosed. The endotoxin nanovesicle comprises: (a) lipopolysaccharide molecules, assembled into a vesicle with a wall surrounding an inner space; and (b) hydrophilic gold nanodots, localized in the wall of the vesicle. ... Health Research Inc

09/07/17 / #20170253569

Thiazolidinone compounds and use thereof

A pharmaceutical composition containing a compound of formula (i) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. ... Health Research Inc

08/31/17 / #20170247660

Progenitor cells, method for preparation thereof and uses thereof

The present application provides progenitor cells and a preparing method thereof. The preparing method comprises obtaining a tissue sample containing myometrium from uterus, treating the tissue sample with collagenase, and culturing the treated tissue sample to obtain the progenitor cells, wherein the progenitor cell is multipotent and immunomodulatory. ... Health Research Inc

08/31/17 / #20170246212

Methods to upregulate and suppress an expression of immunomodulatory cells

The present application provides a method of upregulating an expression of immumodulatory cells in vitro comprising treating the immumodulatory cells with il-25 to increase an expression of pd-l1. The present application also provides a method for treatment of immune disorders by the aforementioned methods. ... Health Research Inc

08/17/17 / #20170232078

Method for prophylaxis and/or treatment of erbb1 positive cancers

Provided are compositions and methods for prophylaxis and/or therapy of erbb1-positive cancer. The compositions include pharmaceutical preparations that contain isolated or recombinant or modified peptidase d (pepd) proteins. ... Health Research Inc

08/10/17 / #20170229511

Amorphous lead oxide based energy detection devices and methods of manufacture thereof

Pbo-based photoconductive x-ray imaging devices are disclosed in which the pbo photoconductive layer exhibits an amorphous crystal structure. According to selected embodiments, the amorphous pbo photoconductive layer may be formed by providing a substrate inside an evacuated evaporation chamber and evaporating lead oxide to deposit a photoconductive lead oxide layer onto the substrate, while subjecting the photoconductive layer to ion bombardment with oxygen ions having an ion energy between 25 and 100 ev. ... Health Research Inc

08/10/17 / #20170226100

Aminothiazole compounds

Aminothiazole compounds of formula (i) shown herein and pharmaceutical compositions containing one of such compounds.. . ... Health Research Inc

08/10/17 / #20170224776

Methods to enhance nerve regeneration utilizing neural stem cells and il12p40

The present application provides a composition and methods to enhance nerve regeneration utilizing at least one component of neural stem cells or il12p40. The composition comprises neural stem cells and a neurotrophic factor, which is constructed by il12p40 as at least one subunit. ... Health Research Inc

07/06/17 / #20170189655

System and method for draining cerebrospinal fluid

A system and/or a method of evacuating cerebrospinal fluid (csf) from a csf reservoir is provided. The system can include a csf reservoir, a reservoir mating piece, and a securing piece. ... Health Research Inc

03/09/17 / #20170066837

Anti-survivin antibodies for cancer therapy

Provided are survivin specific antibodies, nucleic acids encoding the antibodies and methods for treating tumors comprising survivin-expressing cells by administration of the antibodies. The antibody compositions were found to be effective in inhibiting the growth of tumors.. ... Health Research Inc

03/02/17 / #20170057956

Histone deacetylase inhibitors

Fused bicycle indol, indoline, azoindole, or azoindoline compounds of formula (i) set forth herein. Also disclosed are pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing the same. ... Health Research Inc

03/02/17 / #20170055837

Clinical intravital microscope

A clinical intravital microscope with a heavy base; a motorized, mechanized or manual cantilever arm; and a microscope and camera portion at the distal end of the cantilever arm is provided. A method for observing and/or recording conditions such as blood flow, vessel characteristics, such as vessel density, tumor structure, tumor size and dimensions, is provided such that a physician is permitted to observe such information and characteristics in real-time.. ... Health Research Inc

02/16/17 / #20170042761

Shaking device, system, and method

A shaking device includes at least one pad, a mover configured to reciprocally move the pad, and a mount configured to support the mover. The shaking device may be connected with a medical device using a feedback system. ... Health Research Inc

02/09/17 / #20170037448

Use of known compounds as d-amino acid oxidase inhibitors

The invention utilizes virtual screening strategy to seek for current market drugs as anti-schizophrenia therapy drug repurposing. Drug repurposing strategy finds new uses other than the original medical indications of existing drugs. ... Health Research Inc








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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