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Howard Hughes Medical Institute patents


Recent patent applications related to Howard Hughes Medical Institute. Howard Hughes Medical Institute is listed as an Agent/Assignee. Note: Howard Hughes Medical Institute may have other listings under different names/spellings. We're not affiliated with Howard Hughes Medical Institute, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "H" | Howard Hughes Medical Institute-related inventors


Ion-activated photolabile compounds

The presently-disclosed subject matter relates to analyte-activated photolabile compounds. The compounds include the formula: wherein z includes a maskable molecule; l is selected from a bond, c, c(o), o, alkyl, (o)alkyl, and alkoxy; r1 is selected from h, halogen, alkyl, and acyl; each r2 is independently selected from h, alkyl, aryl, and acyl, and is optionally substituted with one or more heteroatoms independently selected from cooh and coo(alkyl); and r3 is selected from h, alkyl, aryl, halogen, cn, oh, o(alkyl), o(aryl), sh, s(alkyl), s(aryl), amine, cho, cooh, coo(alkyl), coo(aryl), po3h2, and so3h, and is optionally substituted with one or more heteroatoms independently selected from n, o, and s, halogen, oh, o(alkyl), o(aryl), sh, s(alkyl), s(aryl), amine, no2, cho, coo, cooh, coo(alkyl), coo(aryl), c(o)nr2, po3h2, and/or so3h. ... Howard Hughes Medical Institute

Continuously variable aperture

An apparatus for a transmission electron microscope includes a housing configured to be attached to the transmission electron microscope; a plunger received in the housing and movable relative to the housing; a first set of pieces coupled to the plunger, the first piece being configured to move relative to the housing in response to the plunger moving relative to the housing; and a second set of pieces positioned in a fixed spatial relationship relative to each other, the second set of pieces and the first set of pieces forming a perimeter of an opening, an extent of the opening being continuously variable by moving the first set of piece relative to the second set of pieces.. . ... Howard Hughes Medical Institute

Video-rate volumetric functional imaging of the brain at synaptic resolution

A scanning microscope includes a light source for generating a light beam having a wavelength, λ, and beam-forming optics configured for receiving the light beam and generating a quasi-bessel excitation beam that is directed into a sample. The quasi-bessel beam has a lateral fwhm and an axial fwhm that is greater than ten times the lateral fwhm, and the beam-forming optics include an excitation objective having an axis oriented in a first direction. ... Howard Hughes Medical Institute

Enhanced fib-sem systems for large-volume 3d imaging

A microscopy system for imaging a sample can include a scanning electron microscope system configured for imaging a surface layer of the sample and a focused ion beam system configured for generating an ion beam for milling the surface layer away from a sample after it has been imaged. A movable mechanical shutter can be configured to be moved automatically into a position between the sample and the scanning electron microscope system, so that when the electron beam is not imaging the sample the movable mechanical shutter is positioned between the sample and the scanning electron microscope system.. ... Howard Hughes Medical Institute

Bessel beam plane illumination microscope

A microscope has a light source for generating a light beam having a wavelength, λ, and beam-forming optics configured for receiving the light beam and generating a bessel-like beam that is directed into a sample. The beam-forming optics include an excitation objective having an axis oriented in a first direction. ... Howard Hughes Medical Institute

Multiview light-sheet microscopy

A live biological specimen is imaged by generating a plurality of light sheets; directing the plurality of light sheets along an illumination axis through the biological specimen such that the light sheets spatially and temporally overlap within the biological specimen along an image plane, and optically interact with the biological specimen within the image plane; and recording, at each of a plurality of views, images of the fluorescence emitted along a detection axis from the biological specimen due to the optical interaction between the light sheets and the biological specimen. The temporal overlap is within a time shift that is less than a resolution time that corresponds to a spatial resolution limit of the microscope.. ... Howard Hughes Medical Institute

Azetidine-substituted fluorescent compounds

The presently-disclosed subject matter includes azetidine-substituted fluorescent compounds, where the compounds may be used as probes, dyes, tags, and the like. The presently-disclosed subject matter also includes kits comprising the same as well as methods for using the same to detect a target substance.. ... Howard Hughes Medical Institute

Materials and methods for serial multiplexed detection of rna in cells and tissues

This disclosure describes materials and methods for effectively performing serial multiplexed fish analysis.. . ... Howard Hughes Medical Institute

Modified ligand-gated ion channels and methods of use

This document relates to materials and methods for controlling ligand gated ion channel (lgic) activity. For example, modified lgics including at least one lgic subunit having a modified ligand binding domain (lbd) and/or a modified ion pore domain (ipd) are provided. ... Howard Hughes Medical Institute

Genetically encoded calcium indicators and methods of use

Genetically encoded calcium indicator (geci) polypeptides and the nucleic acid molecules encoding such polypeptides are provided. In addition, methods of using such nucleic acids and polypeptides in methods of screening for agonists or antagonists of g-protein coupled receptor (gpcr) or ion channels and methods of monitoring neural activity also are provided.. ... Howard Hughes Medical Institute

Genomic probes

Labeled probes, and methods of use thereof, comprise a cas polypeptide conjugated to grna that is specific for target nucleic acid sequences, including genomic dna sequences. The probes and methods can be used to label nucleic acid sequences without global dna denaturation. ... Howard Hughes Medical Institute

Red genetically encoded calcium indicators and methods of use

Protein indicators useful for calcium imaging, in particular, red genetically-encoded calcium indicators (gecis) disclosed herein rival best-of-class green gecis in terms of sensitivity for detecting neural activity, and can be monitored in vivo. The presently-disclosed subject matter further includes a method of monitoring cell activity comprising stimulating a cell comprising a red geci polypeptide; and detecting fluorescence emitted by the cell.. ... Howard Hughes Medical Institute

Large field of view, high resolution microscope

A microscope system including: a source of light; a sample objective configured for focusing the light at a focal plane within a sample; a remote focus unit configured for changing a position of the focal plane along an axis perpendicular to the focal plane; one or more optical element configured for directing the focused light to a location within the focal plane; and a detector configured for detecting light emitted from the focal plane within the sample; wherein the one or more optical element is located after the remote focus unit along a beam path of the light from the source to the sample objective, such that the changing the position of the focal plane along the axis is performed before the directing the focused light to the location within the focal plane.. . ... Howard Hughes Medical Institute

Methods of using fluorescent protein-based indicators

The presently-disclosed subject matter includes fluorescent protein-based indicators for detecting ions, small molecule analytes, or combinations thereof. In some embodiments the indicators include a polypeptide, which itself includes a fluorescent polypeptide, a compound-binding polypeptide, and a polypeptide target of the compound-binding polypeptide. ... Howard Hughes Medical Institute

02/16/17 / #20170045501

Azetidine-substituted fluorescent compounds

The presently-disclosed subject matter includes azetidine-substituted fluorescent compounds, where the compounds may be used as probes, dyes, tags, and the like. The presently-disclosed subject matter also includes kits comprising the same as well as methods for using the same to detect a target substance.. ... Howard Hughes Medical Institute








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