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Icahn School Of Medicine At Mount Sinai patents


Recent patent applications related to Icahn School Of Medicine At Mount Sinai. Icahn School Of Medicine At Mount Sinai is listed as an Agent/Assignee. Note: Icahn School Of Medicine At Mount Sinai may have other listings under different names/spellings. We're not affiliated with Icahn School Of Medicine At Mount Sinai, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "I" | Icahn School Of Medicine At Mount Sinai-related inventors


Therapeutic acid ceramidase compositions and methods of making and using them

. . The present invention relates to a therapeutic composition including a ceramidase mixture and a pharmaceutically acceptable carrier, where the ceramidase mixture includes an inactive acid ceramidase precursor and an active acid ceramidase. The invention also relates to a method of acid ceramidase treatment, including formulating the acid ceramidase used in said treatment as a ceramidase mixture, where the ceramidase mixture includes an inactive acid ceramidase precursor and an active acid ceramidase. ... Icahn School Of Medicine At Mount Sinai

Compositions and methods for treating cancer

A method of treating cancer in a subject in need thereof includes administering to the subject therapeutically effective amounts of a pp2a activator and a protein kinase inhibitor.. . ... Icahn School Of Medicine At Mount Sinai

Compositions and methods for modulating pro-inflammatory immune response

Provided herein are compositions and methods useful for increasing a pro-inflammatory immune response, treating an autoimmune disorder, inflammation, or transplant rejection in a mammal by activating a leukocyte immunoglobulin-like receptor (lilr) protein. Also provided are compositions and methods useful for increasing a pro-inflammatory immune response, treating cancer, and treating infectious disease in a mammal by blocking the activation of a lilr protein.. ... Icahn School Of Medicine At Mount Sinai

Mesoderm and definitive endoderm cell populations

The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy. ... Icahn School Of Medicine At Mount Sinai

Benzothiazole or benzoxazole compounds as sumo activators

Provided are sumo activators, which can enhance sumoylation of serca2a, which are useful in the treatment of heart failure, cardiovascular diseases, cancer, neurodegenerative disorders, viral infection, bacterial infection, liver disease, inflammation, and other diseases.. . ... Icahn School Of Medicine At Mount Sinai

Clinical gene signature-based human cell culture model and uses thereof

The present invention provides a simple and robust human liver cell-based system in which persistent hepatitis c infection, persistent hepatitis b infection or ethanol exposure induces a clinical prognostic liver signature (pls) high-risk gene signature. The cellular model system for hepatocellular carcinoma (hcc)/cirrhosis development and progression may be used in the screening of compounds useful in the treatment and/or prevention of cirrhosis and/or hcc as well as in the identification biomarkers for the prediction of liver disease (especially cirrhosis) progression and hcc. ... Icahn School Of Medicine At Mount Sinai

Immunogenic polypeptides

. . The present invention relates to isolated immunogenic polypeptides and their use. In one aspect, the isolated immunogenic polypeptide includes a scaffold polypeptide having a hairpin loop modified to include one or more epitopes heterologous to the scaffold polypeptide and from an amino acid loop linked by a disulfide bond. ... Icahn School Of Medicine At Mount Sinai

Compositions and methods for inhibiting expression of the alas1 gene

The invention relates to double-stranded ribonucleic acid (dsrna) compositions targeting the alas1 gene, and methods of using such dsrna compositions to alter (e.g., inhibit) expression of alas1.. . ... Icahn School Of Medicine At Mount Sinai

Method of maintaining the anti-depressant effect of ketamine with lithium

Disclosed herein is method for maintaining the anti-depressant effect of ketamine by administering lithium to patients that respond to ketamine treatment.. . ... Icahn School Of Medicine At Mount Sinai

Influenza virus vaccination regimens

Provided herein are immunization regimens for inducing an immune response (e.g., an antibody response) against influenza virus. In specific aspects, the immunization regimens involve the administration of a chimeric hemagglutinin (ha), a headless ha or another influenza virus stem domain based construct (e.g., the ha stem domain or a fragment thereof) to a subject. ... Icahn School Of Medicine At Mount Sinai

Influenza virus vaccines and uses thereof

. . Provided herein are influenza hemagglutinin stem domain polypeptides, compositions comprising the same, vaccines comprising the same and methods of their use.. . ... Icahn School Of Medicine At Mount Sinai

Method of forming a lipid bilayer

The present application is directed, at least in part, to a process for forming droplet interface blayers (dibs). In one or more embodiments, a housing is produced wherein the housing includes at least one aperture that comprises a cis portion and a trans portion, at least one cis electrode receptacle and at least one trans electrode receptacle, wherein the cis electrode receptacle is operatively connected to the cis portion, and the trans electrode receptacle is operatively connected to the trans portion. ... Icahn School Of Medicine At Mount Sinai

Methods for determining recombination diversity at a genomic locus

The present disclosure relates to methods for determining recombination diversity at a genomic locus of interest. The method includes fragmenting nucleic acids isolated from immune cells, ligating adaptors to the fragmented or amplified nucleic acids, and selectively amplifying nucleic acids containing a recombined junction at the genomic locus of interest. ... Icahn School Of Medicine At Mount Sinai

Recombinant rna viruses and uses thereof

Described herein are modified rna virus gene segments and nucleic acids encoding modified rna virus gene segments. Also described herein are recombinant rna viruses comprising modified rna virus gene segments and the use of such recombinant rna viruses for the prevention and treatment of disease.. ... Icahn School Of Medicine At Mount Sinai

10/26/17 / #20170303851

Systems and methods for treating a psychiatric disorder

Systems and methods for treating a subject with a psychiatric disorder are provided in which a therapy session is conducted. In the therapy session, each respective expression image in a plurality of expression images is sequentially displayed. ... Icahn School Of Medicine At Mount Sinai

09/14/17 / #20170261585

Methods for producing a slice-selective adiabatic t2 preparation pulse and devices thereof

A method, magnetic resonance imaging computing device, and a non-transitory computer readable medium for producing a slice-selective adiabatic magnetization t2 preparation pulse for magnetic resonance imaging. A pulse control signal including an adiabatic half passage pulse control signal, an adiabatic full passage pulse control signal, and a reverse adiabatic half passage pulse control signal is generated. ... Icahn School Of Medicine At Mount Sinai

09/14/17 / #20170260488

Automated, multifunctional, engineered cardiac tissue culture and testing bioreactor system

An improved tissue engineering bioreactor and testing platform has been designed that integrates multiple testing and stimulation capabilities. The system allows for growth of multiple tissue strips in parallel with mechanical and electrical stimulation, media perfusion, and the automated monitoring of contractile force and extracellular electrical activity. ... Icahn School Of Medicine At Mount Sinai

08/10/17 / #20170228507

Automatic disease diagnoses using longitudinal medical record data

An example method of automated medical diagnosis includes obtaining an electronic longitudinal data set for each of a plurality of patients, where each data set includes a plurality of measurement values corresponding to a metric, where each measurement value is associated with a respective time point. The method also includes arranging the data sets into two or more clusters. ... Icahn School Of Medicine At Mount Sinai

08/10/17 / #20170228506

Electronic phenotyping technique for diagnosing chronic kidney disease

An example method of diagnosing chronic kidney disease (ckd) includes obtaining an electronic medical record for a patient having medical data. The medical data includes an indication if the patient had been previously diagnosed with ckd, an indication if the patient had previously undergone a kidney transplant, an indication if the patient had previously undergone a renal dialysis procedure, an indication if the patient had previously been diagnosed with another type of kidney disease, one or more glomerular filtration rate (gfr) measurements associated with the patient, an indication if the patient has type 2 diabetes, and/or an indication if the patient has hypertension. ... Icahn School Of Medicine At Mount Sinai

08/03/17 / #20170219578

Peptides, reagents and methods for detecting food allergy

Provided are peptide biomarkers for diagnosis of allergy, monitoring development of clinical tolerance in an allergic individual, and predicting whether an allergic subject is likely to develop clinical or natural tolerance over time. The invention also relates to diagnostic methods and diagnostic kits employing the peptide biomarkers.. ... Icahn School Of Medicine At Mount Sinai

07/20/17 / #20170206460

Systems and methods for causal inference in network structures using belief propagation

Systems and method for perturbing a system include obtaining directed acyclic/cyclic graph candidates {gi, . . ... Icahn School Of Medicine At Mount Sinai

07/06/17 / #20170189484

Ceacam5 peptides for crohn's disease

The present invention relates to small peptides, derived from the n-terminal domain of ceacam5 (carcinoembryonic antigen family member 5), with the ability to stimulate the suppressive activity of cd8+ t cells in crohn's disease. Pharmaceutical formulations, methods to treat patients with crohn's disease, and methods to identify candidate peptides for treatment of crohn's disease patients, are also disclosed.. ... Icahn School Of Medicine At Mount Sinai

06/22/17 / #20170172978

Methods and compositions for treatment of lipid storage disorders

Treating subjects having a lipid storage disorder with a composition comprising a pkc activator, such as bryostatins, bryologs, and polyunsaturated fatty acids. Accordingly, the present disclosure provides methods for treating human subjects suffering from lipid storage disorders, such as niemann-pick disease, by administering pkc activators. ... Icahn School Of Medicine At Mount Sinai

06/08/17 / #20170160361

Methods for producing a semi-adiabatic spectral-spatial spectroscopic imaging sequence and devices thereof

A method, magnetic resonance imaging computing device, and a non-transitory computer readable medium for producing a semi-adiabatic spectral-spatial spectroscopic imaging sequence for magnetic resonance imaging. A pulse control signal comprising a pair of adiabatic pulses and a linear phase pulse is generated. ... Icahn School Of Medicine At Mount Sinai

06/01/17 / #20170152560

Methods for diagnosing risk of renal allograft fibrosis and rejection

Disclosed herein is a method for diagnosing a renal allograft recipient's risk for developing fibrosis of the allograft and allograft loss. The method includes determining the expression levels of certain micrornas, which have been determined to be predictive of an allograft recipient's risk. ... Icahn School Of Medicine At Mount Sinai

05/18/17 / #20170137883

Method for diagnosing subclinical and clinical acute rejection by analysis of predictive gene sets

Disclosed herein are methods for diagnosing acute cellular rejection (acr) of an allograft by analysis of predictive gene sets and kits for practicing these methods.. . ... Icahn School Of Medicine At Mount Sinai

04/20/17 / #20170107469

Method and apparatus to prepare cardiac organoids in a bioreactor system

A bioreactor system for preparing a cardiac organoid chamber and for subsequent testing thereof is described herein and shown in the exemplary drawing figures. The bioreactor system includes a first vessel having a hollow interior and an open top. ... Icahn School Of Medicine At Mount Sinai

04/20/17 / #20170107218

Small molecule transcription modulators of bromodomains

This disclosure relates generally to compounds and compositions comprising one or more indole analogs. These compounds are useful for treating diseases associated with nf-kb and p53 activity, such as cancer and inflammatory diseases.. ... Icahn School Of Medicine At Mount Sinai

03/09/17 / #20170065685

Serca2 therapeutic compositions and methods of use

The present invention provides methods for treating pulmonary hypertension in a subject by delivering a therapeutic adeno-associated virus (aav)-serca2 composition to a subject in need thereof.. . ... Icahn School Of Medicine At Mount Sinai

02/23/17 / #20170052184

Detection methods employing hcv core lipid and dna binding domain monoclonal antibodies

The present disclosure provides detection methods employing hcv core lipid binding domain and dna binding domain monoclonal antibodies or antibody fragments. In certain embodiments, the lipid binding domain monoclonal antibody or antibody fragment recognizes an epitope in amino acids 141 to 161 of hcv core protein and the dna binding domain antibody or antibody fragment recognizes an epitope in amino acids 95-123 (e.g., in amino acids 99-117) of hcv core protein.. ... Icahn School Of Medicine At Mount Sinai

02/16/17 / #20170042840

Use of 1,3-propanedisulfonic acid or pharmaceutically acceptable salts thereof for the treatment of sarcoidosis

The present disclosure relates to methods for the treatment of sarcoidosis. In certain aspects and embodiments, the disclosure provides compositions containing 1,3-propanedisulfonic acid or a pharmaceutically acceptable salt thereof and/or the use of such compositions for the treatment of sarcoidosis. ... Icahn School Of Medicine At Mount Sinai

02/09/17 / #20170037379

Chimeric viruses presenting non-native surface proteins and uses thereof

The present invention provides chimeric negative-stand rna viruses that allow a subject, e.g., an avian, to be immunized against two infectious agents by using a single chimeric virus of the invention. In particular, the present invention provides chimeric influenza viruses engineered to express and incorporate into their virions a fusion protein comprising an ectodomain of a protein of an infectious agent and the transmembrane and cytoplasmic domain of an influenza virus protein. ... Icahn School Of Medicine At Mount Sinai

01/19/17 / #20170015630

Constrained tricyclic sulfonamides

. . Tricyclic chemical modulators of protein phosphatase 2a are disclosed. The compounds are useful to treat cancer, age-onset proteotoxicity, stress-induced depression, inflammation, and acne. ... Icahn School Of Medicine At Mount Sinai

01/19/17 / #20170014494

Sumoylation of serca2a and cardiovascular disease

Methods for treating cardiovascular disease, and in particular heart failure, are provided comprising administering a therapeutically effective amount of a modulator of serca2a post-translation modification such as sumoylation or acetylation. Also provided are methods of treating cardiovascular disease by inhibiting serca2a degradation. ... Icahn School Of Medicine At Mount Sinai








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