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Illumina Cambridge Limited patents


Recent patent applications related to Illumina Cambridge Limited. Illumina Cambridge Limited is listed as an Agent/Assignee. Note: Illumina Cambridge Limited may have other listings under different names/spellings. We're not affiliated with Illumina Cambridge Limited, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "I" | Illumina Cambridge Limited-related inventors


Flow cell package and method for making the same

A flow cell package includes first and second surface-modified patterned wafers and a spacer layer. The first surface-modified patterned wafer includes first depressions separated by first interstitial regions, a first functionalized molecule bound to a first silane or silane derivative in at least some of the first depressions, and a first primer grafted to the first functionalized molecule in the at least some of the first depressions. ... Illumina Cambridge Limited

Systems and methods of improving droplet operations in fluidic systems

Embodiments of present application are directed to micro fluidic devices and particularly digital micro fluidic devices with improved droplet operations, and methods of improving droplet operations in micro fluidic devices.. . ... Illumina Cambridge Limited

Kinetic exclusion amplification of nucleic acid libraries

An example method includes reacting a first solution and a different, second solution on a flow cell by flowing the first solution over amplification sites on the flow cell and subsequently flowing the second solution over the amplification sites. The first solution includes target nucleic acids and a first reagent mixture that comprises nucleoside triphosphates and replication enzymes. ... Illumina Cambridge Limited

Methods of reducing density-dependent gc bias in amplification

The invention provides methods for amplifying nucleic acids, particularly methods for reducing density-dependent gc bias and for reducing nucleic acid damage in a bridge amplification of a nucleic acid template. The invention also provides methods for evaluating the effect of reagents and/or additives on nucleic acid damage during bridge amplification of nucleic acid template strands. ... Illumina Cambridge Limited

Arrays including a resin film and a patterned polymer layer

An example of an array includes a support, a cross-linked epoxy polyhedral oligomeric silsesquioxane (poss) resin film on a surface of the support, and a patterned hydrophobic polymer layer on the cross-linked epoxy poss resin film. The patterned hydrophobic polymer layer defines exposed discrete areas of the cross-linked epoxy poss resin film, and a polymer coating is attached to the exposed discrete areas. ... Illumina Cambridge Limited

Imprinting apparatus

An imprinting apparatus includes a silicon master having a plurality of nanofeatures defined therein. An anti-stick layer coats the silicon master, the anti-stick layer including a molecule having a cyclosiloxane with at least one silane functional group. ... Illumina Cambridge Limited

Surface-based tagmentation

Presented herein are methods and compositions surface-based tagmentation. In particular embodiments, methods of preparing an immobilized library of fragmented and tagged dna molecules on a solid surface are presented. ... Illumina Cambridge Limited

Novel polymers and dna copolymer coatings

Some embodiments described herein relate to new polymer coatings for surface functionalization and new processes for grafting pre-grafted dna-copolymers to surface(s) of substrates for use in dna sequencing and other diagnostic applications.. . ... Illumina Cambridge Limited

Enhanced utilization of surface primers in clusters

Presented herein are methods and compositions for enhancing utilization of surface primers during the surface amplification process. The methods are useful for surface amplification at improved densities. ... Illumina Cambridge Limited

Pyrophosphorolytic sequencing

A method for determining the sequence of a target nucleic acid, including steps of contacting a target nucleic acid with a polymerase to sequentially remove nucleotide triphosphates from the target nucleic acid, wherein the nucleotide triphosphates that are removed have a variety of different base moieties; and distinguishing the different base moieties for the nucleotide triphosphates that are removed. Also provided is a apparatus including a nanopore positioned in a fluid impermeable barrier to form a passage through which a nucleotide triphosphate can pass from a first fluid reservoir to a second fluid reservoir, and a reaction mix in the first fluid reservoir that includes a polymerase, target nucleic acid having two strands, and pyrophosphorolytic concentration of pyrophosphate.. ... Illumina Cambridge Limited

Fluorescent dyes and their uses as biomarkers

The present application relates to new fluorescent dyes and their uses as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.. ... Illumina Cambridge Limited

Reducing dna damage during sample preparation and sequencing using siderophore chelators

Embodiments disclosed herein provide reagents and kits for nucleic acid preparation comprising a siderophore. Embodiments disclosed herein provide methods for preparing a nucleic acid library, which comprise: providing a plurality of nucleic acid molecules from a sample; and manipulating the plurality of nucleic acid molecules in a reagent for nucleic acid preparation comprising a siderophore. ... Illumina Cambridge Limited

Methods and arrays for producing and sequencing monoclonal clusters of nucleic acid

The present disclosure relates to the field of molecular biology and more specifically to microarrays and methods.. . ... Illumina Cambridge Limited

Methods for sequencing a polynucleotide template

The invention relates to methods for pairwise sequencing of a polynucleotide template which result in the sequential determination of nucleotide sequence in two distinct and separate regions of the polynucleotide template.. . ... Illumina Cambridge Limited

11/30/17 / #20170342406

Nucleic acid arrays

The present invention provides methods for creating an array of features on a surface based on content transferred from a plurality of beads to the surface. Nucleic acid content can be transferred using a method including the steps of (a) providing a surface having one or more primer oligonucleotides attached to the surface; (b) providing a pool of beads, wherein beads in the pool have a plurality of templates attached thereto, the plurality comprising multiple copies of a single nucleic acid template sequence; (c) arraying the beads onto the surface by hybridizing the templates to the primer oligonucleotides; and (d) extending the primers to produce copies of the templates attached to the surface.. ... Illumina Cambridge Limited

11/16/17 / #20170327885

Method for sequencing a polynucleotide template

The invention relates to methods for pairwise sequencing of a double stranded polynucleotide template, which permit the sequential determination of nucleotide sequences in two distinct and separate regions on complementary strands of the double-stranded polynucleotide template. The two regions for sequence determination may or may not be complementary to each other.. ... Illumina Cambridge Limited

09/28/17 / #20170275602

Polymerases

Modified dna polymerases have an affinity for dna such that the polymerase has an ability to incorporate one or more nucleotides into a plurality of separate dna templates in each reaction cycle. The polymerases are capable of forming an increased number of productive polymerase-dna complexes in each reaction cycle. ... Illumina Cambridge Limited

08/31/17 / #20170249421

Detecting repeat expansions with short read sequencing data

The disclosed embodiments concern methods, apparatus, systems and computer program products for determining the presence or absence of repeat expansions of interest, including repeat expansions of repeat sequences that are medically significant. Some embodiments provide methods for identifying and calling medically relevant repeat expansions using anchored reads. ... Illumina Cambridge Limited

08/17/17 / #20170237445

Methods and systems for data analysis and compression

The present disclosure provides computer implemented methods and systems for analysing datasets, such as large data sets output from nucleic acid sequencing technologies. In particular, the present disclosure provides for data analysis comprising computing the bwt of a collection of strings in an incremental, character by character, manner. ... Illumina Cambridge Limited

07/27/17 / #20170212123

Methods of nucleic acid sequencing

Provided herein is a method of using transposition to improve methods of sequencing rna molecules. Provided herein is a method of tagging nucleic acid duplexes, such as dna:rna duplexes or dna:dna duplexes. ... Illumina Cambridge Limited

07/20/17 / #20170204458

Labelled nucleotides

Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.. . ... Illumina Cambridge Limited

06/15/17 / #20170166961

Modified nucleosides or nucleotides

Some embodiments described herein relate to modified nucleotide and nucleoside molecules with novel 3′-hydroxy protecting groups. Also provided herein are methods to prepare such modified nucleotide and nucleoside molecules and sequencing by synthesis processes using such modified nucleotide and nucleoside molecules.. ... Illumina Cambridge Limited

05/18/17 / #20170137876

Methods of increasing sequencing accuracy

The present invention provides methods of increasing sequencing accuracy. For example, the methods of the invention use linear amplification to generate a relatively small population of template molecules that may be subsequently amplified into a larger clonal population of dna molecules for sequencing.. ... Illumina Cambridge Limited

05/11/17 / #20170130260

Methods and compositions for preparing sequencing libraries

Embodiments provided herein relate to methods and compositions for next generation sequencing. Some embodiments include the preparation of a template library from a target nucleic acid in contact with a surface, and sequencing the library on the surface. ... Illumina Cambridge Limited

03/09/17 / #20170067104

Labelled nucleotides

Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.. . ... Illumina Cambridge Limited

02/02/17 / #20170029857

Amplification methods to minimise sequence specific bias

Methods for amplifying nucleic acids are provided. The methods can be used to minimise sequence specific bias caused by the preferential amplification of certain nucleic acid sequences. ... Illumina Cambridge Limited

01/26/17 / #20170021325

Preparation of templates for nucleic acid sequencing

The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: providing at least one double-stranded nucleic acid molecule, wherein both strands of the double-stranded nucleic acid molecule are attached to a solid support at the 5′ end, cleaving one or both strands of the double-stranded nucleic acid molecule, and subjecting the cleaved strand(s) to denaturing conditions to remove the portion of the cleaved strand(s) not attached to the solid support, thereby generating a partially or substantially single-stranded template for a nucleic acid sequencing reaction.. . ... Illumina Cambridge Limited

01/05/17 / #20170002408

Labelled nucleotides

The invention provides a nucleotide or nucleoside having a base attached to a detectable label via a cleavable linker, characterised in that the cleavable linker contains a moiety selected from the group comprising: formula (i) (wherein x is selected from the group comprising o, s, nh and nq wherein q is a c1-10 substituted or unsubstituted alkyl group, y is selected from the group comprising o, s, nh and n(allyl), t is hydrogen or a c1-10 substituted or unsubstituted alkyl group and * indicates where the moiety is connected to the remainder of the nucleotide or nucleoside).. . ... Illumina Cambridge Limited

01/05/17 / #20170002407

Labelled nucleotides

Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.. . ... Illumina Cambridge Limited








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