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Immunogen Inc patents


Recent patent applications related to Immunogen Inc. Immunogen Inc is listed as an Agent/Assignee. Note: Immunogen Inc may have other listings under different names/spellings. We're not affiliated with Immunogen Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "I" | Immunogen Inc-related inventors


Methods and pharmaceutical compositions for treating celiac disease and gluten intolerance

The invention concerns methods for protecting a subject in need from a deleterious effect of gluten ingestion. The invention specifically concerns the treatment of celiac disease and gluten intolerance. ... Immunogen Inc

Methods for the acylation of maytansinol

Disclosed is a method of preparing an amino acid ester of maytansinol by reacting maytansinol with an n-carboxyanhydride of an amino acid (nca) in the presence of a drying agent. Also disclosed is an improved method of preparing an amino acid ester of maytansinol in which a nucleophile is added to the reaction mixture after completion of the reaction between maytansinol and an n-carboxyanhydride of an amino acid.. ... Immunogen Inc

Conjugation methods

This invention describes a method of conjugating a cell binding agent such as an antibody with an effector group (e.g., a cytotoxic agent) or a reporter group (e.g., a radionuclide), whereby the reporter or effector group is first reacted with a bifunctional linker and the mixture is then used without purification for the conjugation reaction with the cell binding agent. The method described in this invention is advantageous for preparation of stably-linked conjugates of cell binding agents, such as antibodies with effector or reporter groups. ... Immunogen Inc

Novel benzodiazepine derivatives

The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (i) and (ii), in which the diazepine ring (b) is fused with a heterocyclic ring (cd), wherein the heterocyclic ring is bicyclic or a compound of formula (iii), in which the diazepine ring (b) is fused with a heterocyclic ring (c), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. ... Immunogen Inc

Anti-cd123 antibodies and conjugates and derivatives thereof

The present invention generally relates to antibodies, antigen-binding fragments thereof, polypeptides, and immunoconjugates that bind to cd123 antigen (the α chain of the interleukine 3 receptor, or il-3rα). The present invention also relates to methods of using such cd123-binding molecules for diagnosing and treating diseases, such as b-cell malignancies.. ... Immunogen Inc

Cytotoxic agents comprising new maytansinoids (dm4)

New thiol and disulfide-containing maytansinoids bearing a mono or di-alkyl substitution on the α-carbon atom bearing the sulfur atom are disclosed. Also disclosed are methods for the synthesis of these new maytansinoids and methods for the linkage of these new maytansinoids to cell-binding agents. ... Immunogen Inc

Methods of preparation of conjugates

The present invention is directed to methods of preparing a conjugate of a cell-binding agent and a drug (such as a cytotoxic compound). The methods comprise the use of an imine reactive compound to enable efficient conjugations of cytotoxic compounds with cell binding agents.. ... Immunogen Inc

Diagnostic assays and kits for detection of folate receptor 1

The invention generally relates to antibodies that bind to human folate receptor 1 and diagnostic assays for folate receptor 1-based therapies. Methods of using the antibodies to monitor therapy are further provided.. ... Immunogen Inc

Cytotoxic benzodiazepine derivatives

The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (i)-(vii). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. ... Immunogen Inc

Process for preparing cell-binding agent-cytotoxic agent conjugates

The present invention provides a novel process for preparing a cell-binding agent cytotoxic agent conjugate. The process comprises the steps of: (a) reacting a cytotoxic agent with a bifunctional crosslinking reagent represented by the structural formula(i) or a salt thereof, in a buffer solution comprising a buffering agent to provide a first mixture comprising a cytotoxic agent-linker compound, wherein the buffer solution has high buffer capacity; and (b) reacting the first mixture comprising the cytotoxic agent-linker compound from step (a) with a cell-binding agent in a solution having a ph of 4 to 9 to provide a second mixture comprising the cell-binding agent cytotoxic agent conjugate. ... Immunogen Inc

Methods for formulating antibody drug conjugate compositions

The present invention provides improved methods for formulating therapeutic compositions comprising an antibody drug conjugate (“adc”) that reduce potency variability between batches of adc and provide for administration of such therapeutic compositions within a narrow intended range.. . ... Immunogen Inc

Pharmaceutical formulations and methods of use thereof

This disclosure is directed to antibody-drug conjugates. More specifically, this disclosure is directed to compositions comprising (i) antibody-drug conjugates comprising benzodiazepines, and (ii) a small hydrophobic molecule, methods of treatment using the compositions, and methods of formulating the compositions. ... Immunogen Inc

Cytotoxic benzodiazepine derivatives

The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (i)-(vii). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. ... Immunogen Inc

Cytotoxic benzodiazepine derivatives

The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (i)-(vi). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. ... Immunogen Inc

11/16/17 / #20170327575

Folate receptor 1 antibodies and immunoconjugates and uses thereof

Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to human folate receptor 1 are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided.. ... Immunogen Inc

11/16/17 / #20170327486

Methods for the preparation of charged crosslinkers

Processes for the preparation of charged crosslinkers bearing a sulfonic acid moiety are disclosed. These procedures also optionally include methods to convert the resulting products to substantially a single salt form.. ... Immunogen Inc

10/26/17 / #20170306041

Antibodies and assays for detection of folate receptor 1

The invention generally relates to antibodies that bind to human folate receptor and diagnostic assays for folate receptor 1-based therapies. Methods of using the antibodies to monitor therapy are further provided.. ... Immunogen Inc

09/28/17 / #20170274091

Benzodiazepines and conjugates thereof

Conjugates and compounds for making conjugates which are pbd molecules linked via the n10 position are disclosed, along with the use of the conjugates for treating proliferative diseases, including cancer.. . ... Immunogen Inc

08/24/17 / #20170239367

Anti-folr1 immunoconjugate dosing regimens

Methods of administering immunoconjugates that bind to folr1 are provided. The methods comprise administering an anti-folr1 immunoconjugate to a person in need thereof, for example, a cancer patient, at a therapeutically effective dosing regimen that results in minimal adverse effects.. ... Immunogen Inc

08/10/17 / #20170226220

Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates and methods of making said conjugates

The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.. . ... Immunogen Inc

07/06/17 / #20170189548

Pharmaceutical formulations and methods of use thereof

This disclosure is directed to antibody-drug conjugates. More specifically, this disclosure is directed to compositions comprising (i) antibody-drug conjugates comprising benzodiazepines, and (ii) a small hydrophobic molecule, methods of treatment using the compositions, and methods of formulating the compositions. ... Immunogen Inc

06/29/17 / #20170183419

Novel benzodiazepine derivatives

The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (i) and (ii), in which the diazepine ring (b) is fused with a heterocyclic ring (cd), wherein the heterocyclic ring is bicyclic or a compound of formula (iii), in which the diazepine ring (b) is fused with a heterocyclic ring (c), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. ... Immunogen Inc

06/08/17 / #20170157264

Cross-linkers and their uses

Charged or pro-charged cross-linking moieties and conjugates of cell binding agents and drugs comprising the charged or pro-charged cross-linking moieties and method of making the same.. . ... Immunogen Inc

05/18/17 / #20170137440

Methods for the acylation of maytansinol

Disclosed is a method of preparing an amino acid ester of maytansinol by reacting maytansinol with an n-carboxyanhydride of an amino acid (nca) in the presence of a drying agent. Also disclosed is an improved method of preparing an amino acid ester of maytansinol in which a nucleophile is added to the reaction mixture after completion of the reaction between maytansinol and an n-carboxyanhydride of an amino acid.. ... Immunogen Inc

04/06/17 / #20170095571

Therapeutic combinations comprising anti-folr1 immunoconjugates

Therapeutic combinations of immunoconjugates that bind to folr1 (e.g., imgn853) with anti-vegf agents (e.g., bevacizumab), a platinum-based agent, and/or doxorubicin are provided. Methods of administering the combinations to treat cancers, e.g., ovarian cancers, with greater clinical efficacy and/or decreased toxicity are also provided.. ... Immunogen Inc

03/23/17 / #20170081418

Immunoconjugates targeting cd138 and uses thereof

Disclosed are immunoconjugates having in particular specificity for cd138 expressed on target cells and which display homogenous targeting. The immunoconjugates may be sterially hindered and/or contain a cleavable linker.. ... Immunogen Inc

03/23/17 / #20170080102

Methods for characterizing and treating acute myeloid leukemia

The invention features methods for characterizing and treating acute myeloid leukemia (aml) (e.g., newly diagnosed, relapsed, and refractory aml) in a subject using immunoconjugates of the invention. In one aspect, the invention generally features a method of treating acute myeloid leukemia in a subject (e.g., a human), the method involving administering an effective amount of an immunoconjugate to a pre-selected subject, where the immunoconjugate contains a humanized or chimeric antibody or fragment conjugated to a cytotoxic benzodiazepine dimer compound via a cleavable disulfide linker.. ... Immunogen Inc

02/23/17 / #20170051011

Methods of preparing cytotoxic benzodiazepine derivatives

The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.. . ... Immunogen Inc

02/23/17 / #20170050986

Methods of preparing cytotoxic benzodiazepine derivatives

The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.. . ... Immunogen Inc

02/23/17 / #20170050985

Methods of preparing cytotoxic benzodiazepine derivatives

The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.. . ... Immunogen Inc

02/16/17 / #20170044266

Cytotoxic benzodiazepine derivatives

The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (i)-(vii). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. ... Immunogen Inc

02/09/17 / #20170037080

Preparation of maytansinoid antibody conjugates by a one-step process

The invention provides a one-step process for preparing a cell-binding agent cytotoxic agent conjugate comprising contacting a cell-binding agent with a cytotoxic agent to form a first mixture comprising the cell-binding agent and the cytotoxic agent and contacting the first mixture comprising the cell-binding agent and the cytotoxic agent with a bifunctional crosslinking reagent, which provides a linker, in a solution having a ph of about 4 to about 9 to provide a second mixture comprising the cell-binding agent cytotoxic agent conjugate, wherein the cell-binding agent is chemically coupled through the linker to the cytotoxic agent, free cytotoxic agent, and reaction by-products. The second mixture is then optionally subjected to purification to provide a purified cell-binding agent cytotoxic agent conjugate.. ... Immunogen Inc

02/02/17 / #20170029514

Anti-cd123 antibodies and conjugates and derivatives thereof

The present invention generally relates to antibodies, antigen-binding fragments thereof, polypeptides, and immunoconjugates that bind to cd123 antigen (the α chain of the interleukine 3 receptor, or il-3rα). The present invention also relates to methods of using such cd123-binding molecules for diagnosing and treating diseases, such as b-cell malignancies.. ... Immunogen Inc

01/19/17 / #20170014522

Conjugates of cysteine engineered antibodies

The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (cba) is covalently linked to the cytotoxic agent through an engineered cys, such as an engineered cys in the heavy chain ch3 domain, at a position corresponds to the eu/ou numbering position 442 (or c442) on an antibody cba. The invention also provides methods of preparing the conjugates of the present invention. ... Immunogen Inc

01/05/17 / #20170002393

Compositions and methods for antibody production

Compositions and methods for minimizing antibody disulfide bond reduction are described. In one aspect, a composition is provided for culturing mammalian host cells to express an antibody including an anti-reduction agent that minimizes reduction of a disulfide bond in the antibody or fragment thereof. ... Immunogen Inc

01/05/17 / #20170002096

Conjugation methods

This invention describes a method of conjugating a cell binding agent such as an antibody with an effector group (e.g., a cytotoxic agent) or a reporter group (e.g., a radionuclide), whereby the reporter or effector group is first reacted with a bifunctional linker and the mixture is then used without purification for the conjugation reaction with the cell binding agent. The method described in this invention is advantageous for preparation of stably-linked conjugates of cell binding agents, such as antibodies with effector or reporter groups. ... Immunogen Inc

01/05/17 / #20170000900

Anti-cd37 immunoconjugate and anti-cd20 antibody combinations

Methods of administering immunoconjugates that bind to cd37 (e.g., imgn529) in combination with antibodies that bind to cd20 are provided. The methods comprise administering an anti-cd37 immunoconjugate (e.g., imgn529) and an anti-cd20 antibody to a person in need thereof, for example, a cancer patient.. ... Immunogen Inc








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