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Incept Llc patents


Recent patent applications related to Incept Llc. Incept Llc is listed as an Agent/Assignee. Note: Incept Llc may have other listings under different names/spellings. We're not affiliated with Incept Llc, we're just tracking patents.

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Processor trace-based enforcement of control flow integrity of a computer system

Vaccines comprising an s. Aureus alpha-toxin antigen and a pharmaceutically acceptable carrier are provided, and are useful for treating and preventing infections. . . . . . . . . . . . . . . . . . . . . A computer processing node is described that is configured to perform a control flow integrity (cfi) method on a protected process operating on the processing node. The cfi method includes intercepting a system call originating from execution of the protected process executing in the runtime environment. ... Incept Llc

Biometric authentication apparatus, biometric authentication method, and non-transitory computer-readable storage medium for storing program for biometric authentication

A biometric authentication apparatus includes: a biometric sensor configured to capture an image of a hand of a user; a touch panel configured to output a contact signal indicating contact positions of fingers of the user in response to the reception of an operation by the fingers of the user; and control circuitry configured to display, on the touch panel, a plurality of marks each of which indicates position at which any of the fingers of the user is intended to come into contact with the touch panel, acquire the contact signal output from the touch panel, and reduce in size one or more marks among the plurality of marks during acquiring biometric information from the image captured by the biometric sensor when the control circuitry detects, in accordance with the contact signal, that the fingers of the user are in contact with the plurality of marks.. . ... Incept Llc

Personalized health tracker and method for destination selection based on tracked personalized health information

A method for providing destination guidance based on health risk information, includes receiving a destination request and searching, based on the request, to get a set of destination candidates. Susceptibility of the first user is identified based on retrieved health condition information of the first user. ... Incept Llc

Recommendation based on thematic structure of content items in digital magazine

An online system automatically selects one or more content items in a digital magazine for recommendation based on a common theme of the content items and similarities of the content items. In one aspect, content items are associated with different latent topics. ... Incept Llc

System, apparatus, method, program and recording medium for processing image

An image processing system may include an imaging device for capturing an image and an image processing apparatus for processing the image. The imaging device may include an imaging unit for capturing the image, a first recording unit for recording information relating to the image, the information being associated with the image, and a first transmission control unit for controlling transmission of the image to the image processing apparatus. ... Incept Llc

Identification of high deduplication data

A computer-implemented method includes dividing a data set into a plurality of regions and dividing the plurality of regions into a plurality of chunks of fixed size. The computer-implemented method further includes determining a sample size of the plurality of chunks to be sampled for each region, wherein the sample size is determined based, at least in part, on an acceptance of a likelihood of identifying at least one collision between two regions corresponding to logical entities of a first cluster of logical entities. ... Incept Llc

Identification of high deduplication data

A computer-implemented method includes dividing a data set into a plurality of regions and dividing the plurality of regions into a plurality of chunks of fixed size. The computer-implemented method further includes determining a sample size of the plurality of chunks to be sampled for each region, wherein the sample size is determined based, at least in part, on an acceptance of a likelihood of identifying at least one collision between two regions corresponding to logical entities of a first cluster of logical entities. ... Incept Llc

Systems and methods for assessing quality of input text using recurrent neural networks

Systems and methods for assessing quality of input text using recurrent neural networks is disclosed. The system obtains input text from user and performs a comparison of each word from input text with words from dictionary (or trained data) to determine a closest recommended word for each word in the input text. ... Incept Llc

Methods and systems for creating configurable forms, configuring forms and for form flow and form correlation

This disclosure relates to creating configurable forms and for configuring forms as well as creating configurable flow form process files and configuring flow form process files and for auto-discovering some or all of the available actions that can be performed on a type of record from a set of form flows process files stored in a data store. Establishing a configurable form can include receiving a form file configured with an acceptability filter and at least one non-mandatory form item that is configured to be either on or off and in the applicability filter, and establishing at least one circumstance under which the non-mandatory form item is to be applied in the form file and generating a configurable form file. ... Incept Llc

Mobile device and method

A mobile device comprises a display and a processor. The processor is configured to: intercept information sent from an application, to be displayed on the display; identify an information entity in the intercepted information, comprised in a predefined set of information entity types; reformat appearance of the identified information entity to be displayed on the display; forward the intercepted information including the reformatted appearance of the identified information entity to be displayed on the display. ... Incept Llc

Programmable controller

Provided is a programmable controller capable of simplifying handshake processing between control devices. The programmable controller, which performs the handshake processing in conjunction with a reception-side device, is provided with an output signal area in which a signal to be output to the reception-side device is held, an input signal area in which a signal output by the reception-side device is held, a sequential program execution part configured to execute a sequential program, an output signal temporary area in which an output signal from the sequential program is held, and a handshake processing part configured to copy a signal state of the output signal temporary area in the output signal area and hold the signal state of the output signal area so that the input signal area is notified of a completion signal.. ... Incept Llc

Memory controller, storage device, information processing system, and memory control method

In a memory controller, a request transfer unit transfers a request for demanding transfer of data and data based on the request to each of a plurality of memories in synchronization with a clock signal. A busy time measurement unit measures a busy time which is a time required for access based on the request, for a selected memory which is one memory out of the plurality of memories. ... Incept Llc

System and method for securely connecting to a peripheral device

A device connectable between a host computer and a computer peripheral over a standard bus interface is disclosed, used to improve security, and to detect and prevent malware operation. Messages passing between the host computer and the computer peripherals are intercepted and analyzed based on pre-configured criteria, and legitimate messages transparently pass through the device, while suspected messages are blocked. ... Incept Llc

Read-with overridable-invalidate transaction

A system comprises a number of master devices and an interconnect for managing coherency between the master devices. In response to a read-with-overridable-invalidate transaction received by the interconnect from a requesting master device requesting that target data associated with a target address is provided to the requesting master device, when target data associated with the target address is stored by a cache, the interconnect issues a snoop request to said cache triggering invalidation of the target data from the cache except when the interconnect or cache determines to override the invalidation and retain the target data in the cache. ... Incept Llc

08/09/18 / #20180225206

Read transaction tracker lifetimes in a coherent interconnect system

Apparatus and a corresponding method of operating the apparatus, in a coherent interconnect system comprising a requesting master device and a data-storing slave device, are provided. The apparatus maintains records of coherency protocol transactions received from the requesting master device whilst completion of the coherency protocol transactions are pending and is responsive to reception of a read transaction from the requesting master device for a data item stored in the data-storing slave device to issue a direct memory transfer request to the data-storing slave device. ... Incept Llc

08/09/18 / #20180225109

Techniques of adding security patches to embedded systems

In an aspect of the disclosure, a method, a computer-readable medium, and an apparatus are provided. The apparatus may be an embedded-system device. ... Incept Llc

08/09/18 / #20180225107

Modification of terminal and service provider machines using an update server machine

A method including (i) displaying a first prompt on a terminal display of a terminal machine by running a terminal application, the terminal application comprising first computer-executable instructions and first code that conduct the terminal machine's portion of a dialogue sequence, (ii) accepting a first data entry at the terminal machine, (iii) communicating information associated with the first data entry from the terminal machine to the service provider machine, the service provider machine using a provider application comprising second computer-executable instructions and second code that conduct the service provider machine's portion of the dialogue sequence, and (iv) receiving, at the terminal machine, third code that modifies at least a portion of the first code to produce first updated code, wherein the first updated code adapts the terminal application to display a second prompt for the terminal machine's portion of a modified dialogue sequence with the service provider machine.. . ... Incept Llc

08/09/18 / #20180225009

Stimulus integration apparatus

Apparatus, architecture and methods for integrating and/or presenting stimuli to sensory receptor(s) are provided. An electronically stored value may encode stimuli presentable via electronic display(s) to receptor(s). ... Incept Llc

08/09/18 / #20180224967

Touch sensor

A capacitive touch sensor device comprising set of crossing x and y electrodes whose crossing points form a two-dimensional array of nodes which define a touch sensitive area made up of rectilinear sub-areas bounded by adjacent pairs of x and y electrodes. The main electrode branches are referred to as zeroth order branches, since, in each sub-area, there are also higher order branches arranged such that some higher order x branches interdigitate with some higher order y branches separated by a gap suitable for making a mutual capacitance measurement. ... Incept Llc

08/09/18 / #20180224950

Information processing system and information processing method thereof

Provided is an information processing system implemented to allow various types of services, such as virtual reality games or augmented reality games, to be enjoyed with a perception of reality by using a single manipulation device that may be modified in various forms, and an information processing method thereof. The information processing system includes: a manipulation device including a plurality of fragments each having distinguishment information for distinguishing the plurality of fragments from each other, the manipulation device configured to provide motion information according to a manipulation of a user; and an information processing device configured to provide various types of services by reflecting the motion information received from the manipulation device and a result of processing an image of the manipulation device on basic content for a service.. ... Incept Llc

08/09/18 / #20180224926

Methods and systems for providing haptic feedback for virtual 3d objects

Described herein are various embodiments for enabling realistic haptic feedback for virtual three-dimensional (3d) objects. A real proxy surface is provided for a virtual object, where the proxy surface may be a relief surface, such as a depth-compressed model of the virtual object. ... Incept Llc

08/09/18 / #20180224917

Device and method for controlling application program

A method for operating an electronic device according to various embodiments may comprise the steps of: executing an application program in response to an input by a user; detecting a user perception response period in an execution period of the application program; and transmitting information on the user perception response period.. . ... Incept Llc

08/09/18 / #20180224914

Power transmission and reception control device, power transmission and reception control method, computer program, and input and output control device

[solution] provided is a power transmission and reception control device including: a power transmission and reception control unit configured to control transmission and reception of direct-current power over a direct-current power line through a dc-to-dc converter connected to the direct-current power line; a power transmission and reception management unit configured to request the power transmission and reception control unit to control the dc-to-dc converter; and a power transmission and reception arbitration unit configured to request the power transmission and reception management unit to perform transmission and reception of power through the dc-to-dc converter. When the power transmission and reception arbitration unit instructs the power transmission and reception management unit to set voltage to the direct-current power line, the power transmission and reception management unit causes the power transmission and reception control unit to set the voltage to the direct-current power line a predetermined number of times by using a random number, and if voltage and current of the direct-current power line are set values, the power transmission and reception management unit instructs the power transmission and reception arbitration unit to acquire a control right of the direct-current power line.. ... Incept Llc

08/09/18 / #20180224887

Apparatus and method for asynchronous event timestamping

Methods and apparatuses are described for obtaining a timestamp of an interface event. In one configuration, a host receives an in-band interrupt (ibi) from a sensor. ... Incept Llc

08/09/18 / #20180224867

Autonomous unmanned road vehicle for making deliveries

An autonomous unmanned road vehicle and how it can be used to make deliveries. The unmanned vehicle is capable of operating autonomously on paved roadways. ... Incept Llc

08/09/18 / #20180224864

Human imperceptible signals

Systems, methods, and computer-readable media are disclosed for initiating a response action based at least in part on a human imperceptible signal. An emitting device may emit a human imperceptible signal. ... Incept Llc

08/09/18 / #20180224821

Rich contextualization of automation data

A method of operating an intelligent programmable logic controller (plc) as part of a production process within an automation system includes the intelligent plc receiving automation system data and a semantic context model comprising a plurality of ontologies providing formal specifications of conceptual entities associated with the automation system. The intelligent plc creates one or more semantic annotations for the automation system data using the semantic context model. ... Incept Llc

08/09/18 / #20180224761
08/09/18 / #20180224760

Electrophotographic photoreceptor, method for producing the same, and electrophotographic device including the same

The invention provides an electrophotographic photoreceptor, which undergoes little abrasion over long term use and is able to develop a stable image, as well as a method of producing the same and an electrophotographic device including the same. The electrophotographic photoreceptor includes a conductive substrate; and a photosensitive layer that contains an inorganic oxide and that is formed on the conductive substrate from a coating liquid. ... Incept Llc

08/09/18 / #20180224662

Display device and display method

A display device and a display method are provided. The display device includes a plurality of transparent display units configured to emit imaging light along a same direction and arranged in sequence with spaces therebetween along a light-emitting direction of the imaging light; and a layer-by-layer scan circuit configured to respectively input a plurality of depth images of a same three-dimensional (3d) image into corresponding transparent display units in the plurality of transparent display units, wherein, the plurality of depth images have different depth ranges; and upon each transparent display unit displaying the inputted depth image, the layer-by-layer scan circuit is configured to control transparent display units on a display side of the each transparent display unit to be in a transparent state.. ... Incept Llc

08/09/18 / #20180224629

Focusing control device, focusing control method, focusing control program, lens device, and imaging device

A focusing control device includes: a sensor as defined herein; a first correlation value generation unit as defined herein; a second correlation value generation unit as defined herein; a first phase difference amount measurement unit as defined herein; a second phase difference amount measurement unit as defined herein; a target position determination unit as defined herein; and a lens driving control unit as defined herein, the target position determination unit calculates a temporary target position of the focus lens as defined herein, determines whether or not the target position of the focus lens based on the first phase difference amount falls within a predetermined depth range as defined herein, performs the first process in a case defined herein and performs the second process in a case defined herein, and, in the second process, the target position of the focus lens is determined as defined herein.. . ... Incept Llc

08/09/18 / #20180224608

Fiber optic connector and method of assembling the same

The present invention discloses a fiber optic connector comprises: a ferrule assembly; a spring seat provided behind the ferrule assembly; and a spring provided between the ferrule assembly and the spring seat. The spring seat has a receiving chamber having an insertion port through which a portion of the ferrule assembly is inserted into the receiving chamber; wherein the ferrule assembly is pre-assembled into the receiving chamber of the spring seat in a way that the ferrule assembly is held to be movably engaged with the spring seat. ... Incept Llc

08/09/18 / #20180224579

Antireflection film, manufacturing method of antireflection film, kit including antireflection film and cleaning cloth

There is provided an antireflection film including an unevenness structure having an average cycle shorter than a visible light wavelength on a transparent substrate film, wherein in the unevenness structure, an average aspect ratio of an average height of convex portions or an average depth of concave portions to an average cycle is from 1.0 to 3.0, a water contact angle to an unevenness structure surface is 100° or more, and a specular reflectance is 2.0% or less.. . ... Incept Llc

08/09/18 / #20180224577

Second-order nonlinear optical compound and nonlinear optical element comprising the same

Solution: a chromophore comprising a donor structure d, a π-conjugated bridge structure b, and an acceptor structure a, the donor structure d comprising an aryl group substituted with a substituted oxy group; and a nonlinear optical element comprising said chromophore.. . ... Incept Llc

08/09/18 / #20180224565

Water pumping and injecting multi-layered concentric sphere neutron spectrometer

A water pumping and injecting multi-layered concentric sphere neutron spectrometer includes a neutron detector, a plurality of shells concentrically provided, and a water pumping and injecting device; wherein an innermost shell surrounds a surface of the neutron detector; gaps are formed between adjacent shells for containing liquid; the shells are made of an aluminum material; a valve is arranged on each of the shells except the innermost shell; the water pumping and injecting device is connected to the valve of each of the shells except the innermost shell, so as to input water into the gaps or output the water from the gaps. Compared with conventional neutron spectrometer, weight of the water pumping and injecting multi-layered concentric sphere device and the neutron spectrum detection system of the present invention is greatly reduced, which is conducive to transportation and utilization. ... Incept Llc

08/09/18 / #20180224556

Wireless device having low susceptibility to static electricity

A wireless device includes a circuit board, a communicator disposed on the circuit board, and a casing accommodating the circuit board and the communicator. The casing has a through-hole in a side face. ... Incept Llc

08/09/18 / #20180224554

Vehicle-to-x communication module

A vehicle-to-x communication module which is configured to transmit operating data to a satellite navigation module. In this way, supply of operating data to the satellite navigation module can be facilitated and, in particular, in many cases reception of the operating data by assisted gps (agps) can be dispensed with.. ... Incept Llc

08/09/18 / #20180224552

Compressed-sensing ultrafast photography (cup)

A system and method for compressed-sensing ultrafast photography for two-dimensional dynamic imaging is disclosed. The system and method may capture non-repetitive time-evolving events at up to about 100 billion frames per second. ... Incept Llc

08/09/18 / #20180224551

Intelligent illumination systems using modulated light

The present disclosure describes intelligent illumination systems that use modulated light. For example, in one aspect, a method includes producing, by a light source, modulated illumination in a visible part of the spectrum, detecting three-dimensional image data based on at least a portion of the modulated light produced by the light source and reflected by a scene, and changing a characteristic of the modulated illumination based on the detected three-dimensional image data.. ... Incept Llc

08/09/18 / #20180224545

Active illumination management through contextual information

An illumination module and a depth camera on a near-eye-display (ned) device used for depth tracking may be subject to strict power consumption budgets. To reduce power consumption of depth tracking, the illumination power of the illumination module is controllably varied. ... Incept Llc

08/09/18 / #20180224533

Method and apparatus for an adaptive ladar receiver

Disclosed herein are various embodiments of an adaptive ladar receiver and associated method whereby the active pixels in a photodetector array used for reception of ladar pulse returns can be adaptively controlled based at least in part on where the ladar pulses were targeted. Additional embodiments disclose improved imaging optics for use by the receiver and further adaptive control techniques for selecting which pixels of the photodetector array are used for sensing incident light.. ... Incept Llc

08/09/18 / #20180224513

Method and magnetic resonance apparatus for generating a weighting matrix for reducing artifacts with parallel imaging

In a magnetic resonance (mr) apparatus and an operating method therefor, the mr apparatus has multiple reception coils each having an associated reception channel, a reference dataset is obtained from an examination volume of a subject, wherein the reference dataset completely fills a region of k-space. In a computer, a subregion of the examination volume is determined that has a lower homogeneity than other subregions of the examination volume, and the computer also determines at least one of the reception channels in which raw data signals are received that have a higher intensity in the determined subregion than others of the reception channels. ... Incept Llc

08/09/18 / #20180224500

Smart vibration wafer with optional integration with semiconductor processing tool

A test wafer having two spaced-apart accelerometers mounted thereon is disclosed. The accelerometers may be positioned at locations located along a common axis passing through the center of gravity of the test wafer. ... Incept Llc

08/09/18 / #20180224499

Reliability management system and operation thereof

A reliability management system and its operation method is presented. The reliability management system comprises instructions stored in a computer-readable non-transitory storage medium, with said instructions executable by one or more hardware processors communicating with the storage medium, the system comprises a reliability manager and a reliability test requestor (rtr). ... Incept Llc

08/09/18 / #20180224495

Electric-current sensing device, load driving system, and method for manufacturing electric-current sensing device

There are provided an electric-current sensing device capable of detecting an electric current with high accuracy, a load driving system, and a method for manufacturing the electric-current sensing device. According to one embodiment, the electric-current sensing device includes a sense igbt through which an electric current proportional to an electric current flowing through a main igbt flows. ... Incept Llc

08/09/18 / #20180224459

Nanobody conjugates and protein fusions as bioanalytical reagents

Systems and methods for detecting a target protein using a nanobody-peptide receptor pair are described.. . ... Incept Llc

08/09/18 / #20180224456

Method for determining a subject's probability to suffer from pancreatic cancer

A method for determining a subject's probability to suffer from pancreatic cancer, wherein the level of platelet glycoprotein v (gp5), or a peptide fragment thereof is used as a biomarker. An increased level of gp5, or a peptide fragment thereof, is indicative for an increased probability to suffer from pancreatic cancer.. ... Incept Llc

08/09/18 / #20180224455

Using phage epitopes to profile the immune response

The present disclosure provides compositions and methods for using one or more polypeptide probes to profile an immune response. The polypeptide probe can be used to detect one or more antibodies from a sample. ... Incept Llc

08/09/18 / #20180224450

Use of amino acid sequences from mycobacterium tuberculosis or corresponding nucleic acids for diagnosis and prevention of tubercular infection, diagnostic kit and vaccine therefrom

The present invention refers to the use of gene sequences or portions thereof characterized in that the same belong to the classes of in vitro and ex vivo induced, repressed or conserved genes in mycobacterium tuberculosis currently infected human macrophages and to corresponding peptides or consensus peptides or proteins for the preparation of specific bio-markers for the diagnosis and prevention of active or latent disease.. . ... Incept Llc

08/09/18 / #20180224447

Immunologically active polypeptide

Disclosed are immunomodulatory polypeptides that elicit an unusual induced cytokine profile, compositions comprising such polypeptides, compositions comprising antibodies that specifically bind to such polypeptides, and methods of using the same, including in cancer treatment, in the treatment of autoimmune diseases, in organ transplantation and for reducing graft rejection, for promoting fertility, and for identifying a neutrophil subset and/or other cellular subset including by flow cytometry. Pharmaceutical compositions and kits, and treatment methods are also disclosed.. ... Incept Llc

08/09/18 / #20180224438

Stabilized vesicle-functionalized microparticles for chemical separations and rapid formation of polymer frits in silica capillaries using spatially-defined thermal polymerization

Surface-modified silica microparticles that are functionalized with stabilized phospholipid vesicles are described herein. These stabilized vesicles can be functionalized with either transmembrane receptors or membrane associated receptors and used for affinity pull-down assays or other chromatographic separation modalities to provide affinity capture/concentration of low abundance ligands in complex mixtures with minimal sample preparation. ... Incept Llc

08/09/18 / #20180224422

Controlled tunnel gap device for sequencing polymers

The invention includes compositions, devices, and methods for analyzing a polymer and/or polymer unit. The polymer may be a homo or hetero-polymer such as dna, rna, a polysaccharide, or a peptide. ... Incept Llc

08/09/18 / #20180224417

Microalgal flour compositions of optimised sensory quality

Thus, the present invention relates to a method for determining the organoleptic quality of a microalgal flour composition, comprising determining the total content of 13 volatile organic compounds, the 13 volatile organic compounds being heptanal, 3-octen-2-one, 2,4-heptadienal, 3,5-octadien-2-one, 2,4-nonadienal, 2,4-decadienal, hexanoic acid, 2-ethylhexanoic acid, heptanoic acid, myristate-1, laurate-1, myristate-2 and geranyl acetone.. . ... Incept Llc

08/09/18 / #20180224386

Sensor fitting for biotech process bag

A fluid process application bag includes a flexible film body having an opening, a port plate sealed around the opening of the flexible film body, a sensor fitting and a sensor contained within the sensor fitting. The port plate has a receptacle defining a passage in fluid communication with an interior of the flexible film body and the sensor fitting has a body portion seated within the passage of the receptacle and is coupled to the receptacle. ... Incept Llc

08/09/18 / #20180224372

Fog detection method

The present disclosure relates to a fog detection method in a vehicle comprising the steps of: providing a first fog sensor with a first transmitter emitting a first encoded optical signal into a vehicle's surroundings, and an associated first receiver for receiving an optical signal reflected from the vehicle's surroundings, and a first analyzing unit for decoding, analyzing and providing a first detection result related to the reception, wherein, for encoding, a code is selected among a plurality of possible codes (a,b,c) by the first transmitter in a code selection, and the code selection is communicated from the first transmitter to the first receiver and/or the analyzing unit, wherein, upon analyzing the signal received from the first receiver by the first analyzing unit, the code selection is used for identifying the first encoded optical signal in the received signal.. . ... Incept Llc

08/09/18 / #20180224356

Interface designed with differential pumping and built-in figure of merit method to monitor chambers where environmentally sensitive samples are prepared and transferred for analysis

In some embodiments, a system may function to transfer samples in a controlled environment. The system may include a sample container configured to convey a sample from a first device to a second device. ... Incept Llc

08/09/18 / #20180224305

Method for manufacturing a measurement sensor for a motor vehicle

A method for manufacturing a measurement sensor for a motor vehicle, having a body and an electronic measurement module mounted in the body. The method including molding the body of the sensor so as to define, in one and the same material, a base for fastening the sensor, an element for receiving the electronic measurement module, delineating a space for receiving the electronic measurement module and including a first cylindrical portion with a circular cross section and a second cylindrical portion with a circular cross section, the diameter of the second cylindrical portion being smaller than the diameter of the first cylindrical portion, and a seal made from material of the second portion, mounting the electronic measurement module in the reception space, and overmolding the element for receiving the electronic measurement module.. ... Incept Llc

08/09/18 / #20180224296

Image processing system and image processing method

An image processing system includes: an imaging device mounted in a vehicle and an information processing device. The vehicle includes an image acquiring unit configured to acquire a plurality of images captured by the imaging device. ... Incept Llc

08/09/18 / #20180224271

System and process for roof measurement using imagery

The present disclosure describes systems and processes, including processes in which first location data is received. Visual access to a first image corresponding to the first location data is provided, the first image including a roof structure of a building. ... Incept Llc

08/09/18 / #20180224267

Multiple reference oct system

The invention provides for generating a set of signature signals that correspond to a range of depths within a target. These signature signals can include multiple individual reference signals and be can modified to compensate for specific characteristics of the target. ... Incept Llc

08/09/18 / #20180224142

Site-customized benchmark for operating an air conditioning system in real time

A system for customizing an hvac system for operation at a specific site requires defining a benchmark which is based on environmental data taken from the site, and on operational data taken from the hvac system at the site. For the present invention, this benchmark establishes limits for acceptable environmental conditions at the site and appropriate ranges for cost-effective, operational parameters for the hvac system. ... Incept Llc

08/09/18 / #20180224087

Lens protection for high intensity luminaires

A luminaire is provided that includes a light source comprising at least one light-emitting diode (led) and a coated lens. The coated lens includes a lens comprising a plastic material and a coating configured to reduce a susceptibility of the lens to scratching, to reduce a buildup of static electricity on the surface of the lens, and to reduce cracking of the lens coating from thermal cycling of the lens.. ... Incept Llc

08/09/18 / #20180224034

Emergency detachment device of fluid handling device

An object is to provide an emergency detachment device of a fluid handling device, the emergency detachment device having exceptional heat insulation performance and making it possible to handle extremely-low-temperature fluids such as liquid hydrogen. A first coupler 2 and a second coupler 3 are provided with a vacuum section 10 between an inner pipe section 5 and an outer pipe section 6, and are provided with two valves 1 in series. ... Incept Llc

08/09/18 / #20180224029

Autonomous connection evaluation and automated shoulder detection for tubular makeup

A method of connecting a first threaded tubular to a second threaded tubular includes engaging the threads of the tubulars and rotating the first tubular relative to the second tubular to makeup a threaded connection. The method further includes, during makeup of the threaded connection: measuring time, measuring torque applied to the connection, and measuring turns of the first tubular. ... Incept Llc

08/09/18 / #20180223967

Two piece piston with venting

A piston assembly for a tensioner which has a hollow piston body having a first end and a second end; and a cap. At least a portion of the cap fits into the first end of the piston body. ... Incept Llc

08/09/18 / #20180223762

Abnormality diagnosis apparatus and abnormality diagnosis method for pressure sensor of internal combustion engine

An abnormality diagnosis apparatus is an abnormality diagnosis apparatus for a pressure sensor provided in a purge passage that provides communication between an intake passage of an internal combustion engine and a canister, the pressure sensor being closer to the intake passage than a purge valve and a check valve are, the purge valve opening and closing the purge passage, the abnormality diagnosis apparatus for the pressure sensor including: a first determination unit that determines whether the purge valve is being kept in a closing state and a fuel cut in which fuel injection in the internal combustion engine is stopped is being executed; and a second determination unit that determines whether the pressure sensor is abnormal, based on a detection value of the pressure sensor, when the positive determination is made by the first determination unit.. . ... Incept Llc

08/09/18 / #20180223725

Diffuser in wastegate turbine housings

A number of variations may include a turbine housing comprising a turbine body; an inlet passage and an outlet passage connected to the turbine body; a wastegate passage operatively connected to the outlet passage; a diffuser positioned within the outlet passage comprising at least one radial opening; wherein the first flow passage accepts fluid flow from the wastegate passage and the second flow passage accepts fluid flow from the turbine wheel; wherein a first end of the diffuser is attached to a first end of the turbine outlet and a second end of the diffuser is attached to a second end of the turbine outlet so that fluid flow from the first flow passage is directed into the second flow passage through the at least one radial opening before exiting the outlet passage, and wherein the at least one radial opening minimizes turbulence of fluid flow exiting the turbine housing.. . ... Incept Llc

08/09/18 / #20180223700

Thermal energy recovery device

Provided is a thermal energy recovery device in which a site of a circulation flow path between an evaporated portion and an expander can be avoided having too high temperature upon stoppage of power recovery by a power recovery machine. The thermal energy recovery device includes an evaporator (10), an expander (12), a power recovery machine (14), a condenser (16), a pump (18), a circulation flow path (20), a cooling flow path (30) for supplying working medium of liquid phase flowing out of the pump (18) partially to a site of the circulation flow path (20) between the evaporator (10) and the expander (12), an on-off valve (v1) provided in the cooling flow path (30), and a control unit (40), in which upon reception of a stop signal for stopping power recovery by the power recovery machine (14), the control unit (40) opens the on-off valve (v1).. ... Incept Llc

08/09/18 / #20180223698

Thermal energy recovery device

Provided is a thermal energy recovery device in which poor lubrication of a bearing can be inhibited when an expander is driven. The thermal energy recovery device includes an evaporator (10), an expander (20), a power recovery machine (30), a condenser (40), a pump (50), a circulation flow path (60), a cooling flow path (70) for supplying working fluid from the pump (50) partially to the power recovery machine (30), an on-off valve (v1) provided in the cooling flow path (70), and a control unit (80), in which the expander (20) has a rotor (21), a bearing (22), and a primary casing (23), and in which the power recovery machine (30) has a power recovery unit (31) and a secondary casing (35), and in which upon reception of a stop signal for stopping power recovery by the power recovery machine (30), the control unit (80) closes the on-off valve (v1).. ... Incept Llc

08/09/18 / #20180223658

Method and apparatus for measuring characteristics of fluid in a reservoir

Disclosed are methods in which measurements are obtained from a plurality of sensors secured in spaced relation to one another across at least a portion of the depth of reservoir of some form in order to identify one or more characteristics of the fluids within the reservoir. The sensors are used to monitor ambient forces exerted by fluids within the tank proximate each sensor. ... Incept Llc

08/09/18 / #20180223619

Subsea system and methodology utilizing production receptacle structure

A technique facilitates deployment of equipment, e.g. An electric submersible pumping system, in a subsea production operation. ... Incept Llc

08/09/18 / #20180223607

Toe casing

A toe casing is made of a material different from conventional casing, and may be deployed in an open-hole section of a well that is not economically accessible by conventional casing. The toe casing may be made of a material that more easily conforms to the well bore, such as aluminum alloy, titanium alloy, or a composite material. ... Incept Llc

08/09/18 / #20180223566

Lock assembly for securing a storage container

A lock assembly for securing a storage container comprises a first lock having a first lock body and a shackle, the first lock having a first locked condition wherein the shackle is locked to the first lock body and a first unlocked condition wherein the shackle is unlocked from the first lock body. The first lock has a first key receptacle for actuating the first lock between the first locked condition and the first unlocked condition. ... Incept Llc

08/09/18 / #20180223557

Platform for a cemetery lowering device

A platform for a cemetery lowering device comprising a one-piece base having a tapered edge and a non-skid surface, wherein the one-piece base comprises an opening for a casket to be lowered through the base, a frame and skin, and one or more receptacles for adjustable-height footings. The frame and skin may be formed of a single piece of polymer, fiberglass, or metal. ... Incept Llc

08/09/18 / #20180223434

Vapor growth apparatus, and vapor growth method

A vapor growth apparatus has a reaction chamber, a gas supply part to supply a gas to the reaction chamber, a heater to heat the substrate from a surface opposite to a film growth surface of the substrate, an irradiation part to emit an optical signal to the film growth surface, a light receiving part to receive the reflected optical signal, a first light receiving range determination part to determine whether a light receiving position of the optical signal in the light receiving part is out of a predetermined first light receiving range, and a position deviation detection part to judge that the substrate has caused position deviation, a rotation part to rotate the substrate via a susceptor, a purge gas supply part to supply a purge gas into the rotation part, and a control part to control a supply amount of the purge gas.. . ... Incept Llc

08/09/18 / #20180223389

Measurement apparatus for measuring a volume of a desired solid component in a sample volume of a solid-liquid slurry

The invention discloses a measurement apparatus for measuring a volume of a desired solid component in a sample volume of a solid-liquid slurry. The sample volume of the slurry is received into a receptacle and screened to separate out the desired solid component from a remainder of the slurry, whereby the solid component is retained in the receptacle to form a bed therein and the remainder is exhausted. ... Incept Llc

08/09/18 / #20180223371

Fgfr expression and susceptibility to an fgfr inhibitor

A method of selecting a subject suffering from a cancer for a therapeutic regimen of administration of a pharmaceutical composition comprising an effective amount of an fgfr inhibitor is described, which method comprises (1) the taking of a tumor or liquid biopsy from the subject; (2) determination of the level of expression of any or all of fgfr1, fgfr2 and fgfr3, and (3) comparison of the determined level of expression of at least one of fgfr1, fgfr2 and fgfr3 with a pre-established threshold value, and declaring the subject eligible for the therapeutic regimen if the determined level exceeds the threshold value. The invention also relates to a method of personalized cancer therapy comprising selection of a subject by the above-described method and subjecting the subject to a therapeutic regimen that comprises administration of a pharmaceutical composition comprising an effective amount of an fgfr inhibitor.. ... Incept Llc

08/09/18 / #20180223362

Methods of predicting osteoarthritis

The present invention relates generally to methods for predicting progression, initiation and susceptibility of osteoarthritis in human subjects using their genotype test results.. . ... Incept Llc

08/09/18 / #20180223327

Method for determining antimicrobial susceptibility of a microorganism

The present invention provides methods for determining the antimicrobial susceptibility of a microorganism in a clinical sample said method comprising removing a test aliquot from a clinical sample culture before the culture reaches 0.5 mcfarland units, isolating the microbial cells and transferring the cells into a suitable culture medium for microbial growth, and performing an ast assay using the isolated microbes, wherein the concentration of microbial cells in the microbial cells used to set up the ast assay is measured before the degree of microbial growth in the different growth conditions of the ast assay is measured. Devices for determining the antimicrobial susceptibility of a microorganism in a clinical sample are also provided.. ... Incept Llc

08/09/18 / #20180223326

Method for measuring complement-dependent bactericidal function with respect to pneumococci

The present invention relates to a measurement method for complement-dependent bactericidal activity against streptococcus pneumoniae, and provides a measurement method capable of measuring complement-dependent bactericidal activity against streptococcus pneumoniae of any capsular serotype. Complement-dependent bactericidal activity against streptococcus pneumoniae is measured using capsule-deficient streptococcus pneumoniae, that is, non-encapsulated or substantially non-encapsulated, or transparent streptococcus pneumoniae. ... Incept Llc

08/09/18 / #20180223306

Artificial salt tolerant protein, its synthetic method and coding gene thereof and use of said coding gene

This invention relates to an artificial salt tolerant protein nlea with the amino acid sequence shown in seq id no.1 and a synthetic method of salt tolerant protein nlea comprising the steps of retrieving different types of lea proteins from lea database; making multiple sequence alignment on different types of lea proteins to obtain conserved short peptides; selecting hydrophilic short peptides with a hydrophilicity index higher than 3.5 from conserved short peptides; arranging and splicing hydrophilic short peptides in the order of isoelectric point size from large to small, to obtain salt tolerant protein nlea. This invention involves bioinformatics analysis by retrieving different lea conserved amino acid sequences of lea protein data. ... Incept Llc

08/09/18 / #20180223305

Transgenic plants having increased tolerance to aluminum

Methods and materials for modulating aluminum tolerance in plants are disclosed. For example, nucleic acids encoding aluminum tolerance-modulating polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells. ... Incept Llc

08/09/18 / #20180223304

Transgenic plants having increased tolerance to aluminum

Methods and materials for modulating aluminum tolerance in plants are disclosed. For example, nucleic acids encoding aluminum tolerance-modulating polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells. ... Incept Llc

08/09/18 / #20180223303

Sequence-determined dna fragments and corresponding polypeptides encoded thereby

The present invention provides dna molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The dna molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an utr or as a 3′ termination sequence, and are also useful in controlling the behavior of a gene in the chromosome, in controlling the expression of a gene or as tools for genetic mapping, recognizing or isolating identical or related dna fragments, or identification of a particular individual organism, or for clustering of a group of organisms with a common trait. ... Incept Llc

08/09/18 / #20180223287

Fibrotic treatment

The present invention relates to a method for the treatment of fibrosis, in particular cardiac fibrosis, comprising the administration of an inhibitor of insulin-regulated aminopeptidase (irap). Preferable the irap inhibitor is chosen from the group including hfi-419, ha-08, al-40, hfi-437, val-tyr-ile-his-pro-phe (otherwise known as angiotensin iv or ang iv), c[cys-tyr-cys]-his-pro-phe, and c[hcy-tyr-hcy]-his-pro-phe.. ... Incept Llc

08/09/18 / #20180223278

Functionally-modified oligonucleotides and subunits thereof

Functionally-modified oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3′ and/or 5′-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mrna splice products produces beneficial therapeutic effects.. ... Incept Llc

08/09/18 / #20180223275

Methods and materials for cloning functional t cell receptors from single t cells

This document provides methods and materials involved in cloning functional tcrs from single t cells. For example, methods and materials for obtaining nucleic acid encoding a tcr from a single t cell and arranging that nucleic acid to form nucleic acid vectors successfully designed to express a tcr, kits for obtaining nucleic acid encoding a tcr from a single t cell and arranging that nucleic acid to form nucleic acid vectors successfully designed to express a tcr, methods for making such kits, collections of nucleic acid primers designed to amplify the entire coding sequence of both variable regions for each expressed v segment for functional αβ or γδ tcrs of a particular mammalian species, methods for using such collections of nucleic acid primers to clone functional tcrs from single t cells, and kits containing such collections of nucleic acid primers to clone functional tcrs from single t cells are provided.. ... Incept Llc

08/09/18 / #20180223272

Method and device for non-thermal extraction of phytochemicals from macroalgae

A method is for the extraction of a phytochemical, e.g., peptide or protein, or a chemical element from a macroalgae, by applying pulsed electric field (pef)- or continuous electric field (cef)-treatment to the macroalgae in a solvent, under pressure higher than the ambient pressure. A device and system carry out this method.. ... Incept Llc

08/09/18 / #20180223268

Polypeptides having cellobiohydrolase activity and polynucleotides encoding same

Disclosed herein are polypeptides having cellobiohydrolase activity, catalytic domains, carbohydrate binding modules and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate binding modules. Disclosed herein are nucleic acid constructs, vectors and host cells comprise the polynucleotides as well as their uses, and methods of producing the polypeptides, catalytic domains, carbohydrate binding modules.. ... Incept Llc

08/09/18 / #20180223265

Engineered transaminase polypeptides for industrial biocatalysis

The present disclosure provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions. The disclosure also provides polynucleotides encoding the engineered transaminase polypeptides, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases for the production of chiral amine compounds.. ... Incept Llc

08/09/18 / #20180223264

Engineered glycosyltransferases and steviol glycoside glucosylation methods

The present invention provides engineered glycosyltransferase (gt) enzymes, polypeptides having gt activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention provides engineered sucrose synthase (sus) enzymes, polypeptides having sus activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. ... Incept Llc

08/09/18 / #20180223262

Recombinant k1-5 bacteriophages and uses thereof

The present disclosure provides compositions including recombinant k1-5 bacteriophages, methods for making the same, and uses thereof. The recombinant k1-5 bacteriophages disclosed herein are useful for the identification and/or antibiotic susceptibility profiling of specific bacterial strains/species present in a sample.. ... Incept Llc

08/09/18 / #20180223256

Modified t cells and their uses in treating cancer

Provided herein are compositions and methods for treating cancer. The compositions include a modified t cell comprising a nucleic acid encoding a calcium translocating channelrhodopsin (catch) polypeptide. ... Incept Llc

08/09/18 / #20180223255

Activation and expansion of t cells

The present disclosure relates to compositions, methods, and systems for selectively activating and/or expanding t cells for use in therapy. For example, the method may include contacting a population of t cells with an agent capable of binding an extracellular domain of a chimeric antigen receptor (car) that is expressed on the surface of the population of t cells.. ... Incept Llc

08/09/18 / #20180223247

Method for optimising the production efficiency, organoleptic quality and stability over time of a protein-rich microalgae biomass

The present invention relates to a method for optimising the downstream processing of a protein-rich microalgae biomass of the chlorella genus previously prepared by fermentation in heterotrophic conditions and in the absence of light, comprising: 1) providing biomass comprising more than 50% protein by dry weight of biomass; next, at low temperature, carrying out the following steps: 2) harvesting the biomass at the end of fermentation, 3) washing and concentrating the biomass, 4) optionally, lysing the biomass, next, without low temperature stress, 5) optionally, concentrating the biomass slurry, 6) applying heat treatment, 7) drying the biomass obtained in this way in order to obtain the product, a step of adjusting the ph to 7 being applied before or after the heat treatment step 6).. . ... Incept Llc

08/09/18 / #20180223245

Method for thermal permeabilization of a microalgae biomass

Described are methods for thermal permeabilization of the biomass of microalgae of the chlorella genus. The methods are useful in recovering the soluble fractions, including polypeptides and saccharide, of the microalgae.. ... Incept Llc

08/09/18 / #20180223211

Low transition temperature mixtures or deep eutectic solvents and processes for preparation thereof

A low transition temperature mixture (lttm) or deep eutectic solvent (des) useful as a lubricating oil base stock and lubricating oil including a eutectic mixture of at least a first component and at least a second component. The at least first component comprises a hydrogen bond acceptor and the at least second component comprises a hydrogen bond donor. ... Incept Llc

08/09/18 / #20180223109

Abradable dimensionally stable preparation containing platelet-shaped particles

The invention relates to a dimensionally stable preparation which can be abraded on flat materials, containing a translucent water-based polymer-containing carrier composition and platelet-shaped solid particles. The platelet-shaped solid particles have an average maximum diameter ranging from 2 to 40 μm and are contained in the preparation in a proportion by volume specified by the selected particle size in order to achieve a sheen which is clearly perceptible to the human eye while simultaneously having good abrasion properties. ... Incept Llc

08/09/18 / #20180223003

Novel chelator and use thereof

The present invention relates to dimeric pentadentate chelators with exceptionally strong binding of metal ions, for detection, immobilization and purification of biomolecules. Dimeric chelators offer a cooperativity of binding of two adjacent immobilized metal ions simultaneously to a histidine-tagged biomolecule, which gives advantageous properties regarding strength of binding compared to a corresponding monomer chelator. ... Incept Llc

08/09/18 / #20180222997

Compositions and methods for diagnosing and treating cancer

An isolated antibody that specifically binds to an extracellular domain of two or more human fzd receptors and inhibits growth of tumor cells is described. Also described is a method of treating cancer comprising administering an antibody of the present disclosure in an amount effective to inhibit tumor cell growth.. ... Incept Llc

08/09/18 / #20180222995

Use of chimeric antigen receptor modified cells to treat cancer

The present disclosure relates to compositions and methods for compositions, methods, and kits for treating cancer using chimeric antigen receptor (car) modified cells. Some embodiments of the present disclosure relate to an isolated nucleic acid sequence encoding car. ... Incept Llc

08/09/18 / #20180222993

Bispecific anti-human cd20/human transferrin receptor antibodies and methods of use

Herein are provided bispecific anti-human cd20/human transferrin receptor antibodies and methods of using the same.. . ... Incept Llc

08/09/18 / #20180222992

Bispecific anti-human a-beta/human transferrin receptor antibodies and methods of use

Herein are provided bispecific anti-human a-beta/human transferrin receptor antibodies and methods of using the same.. . ... Incept Llc

08/09/18 / #20180222986

Cancer metastasis inhibitor

The present inventors used a model of intrasplenically induced liver metastasis to determine whether or not nf-κb activation in the liver is involved in the onset of metastatic tumors. When ikkβ was deleted from both liver cells and hematopoietically-derived cells, the onset of tumors was reduced remarkably. ... Incept Llc

08/09/18 / #20180222978

Muscarinic acetylcholine receptor binding agents and uses thereof

Agents that specifically bind to a muscarinic acetylcholine receptor in a conformationally specific way can be used to induce a conformational change in the receptor. Such agents have therapeutic applications and can be used in x-ray crystallography studies of the receptor. ... Incept Llc

08/09/18 / #20180222971

Compounds and methods for treating pain

This disclosure provides compositions and methods for controlling pain. In particular the disclosure provides a method for controlling pain comprising co-administration of an ngf antagonist and a tnfα antagonist. ... Incept Llc

08/09/18 / #20180222967

Methods for treating pain using antibodies to kallidin and des-arg10-kallidin

The invention provides antibodies that specifically bind to kallidin or des-arg10-kallidin. The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-kallidin or des-arg10-kallidin antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. ... Incept Llc

08/09/18 / #20180222965

Fc variants that improve fcrn binding and/or increase antibody half-life

The present invention discloses the generation of novel variants of fc domains, including those found in antibodies, fc fusions, and immuno-adhesions, which have an increased binding to the fcrn receptor and/or increased serum half-life.. . ... Incept Llc

08/09/18 / #20180222963

Albumin variants

The present invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The present invention also relates to fusion polypeptides and conjugates comprising said variant albumin.. ... Incept Llc

08/09/18 / #20180222962

Single-chain trail-receptor agonist proteins

Provided herein are specific trail receptor agonist proteins, nucleic acids encoding the same, and methods of treating a subject having a trail-associated disease or disorder. The trail receptor agonist proteins provided herein comprise three soluble trail domains and an fc fragment. ... Incept Llc

08/09/18 / #20180222961

Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers

The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. ... Incept Llc

08/09/18 / #20180222960

Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof

The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.. . ... Incept Llc

08/09/18 / #20180222959

Exposed collagen-targeted fusion cytokine for immune modulation in invasive cancers and lesions of infections

Provided herein are new compositions and methods to target pharmaceutical agents to pathological areas by utilizing fusion polypeptides. These fusion polypeptides contain two or more domains: (i) aptamer sequences that bind to exposed collagenous (xc-) proteins present in pathological areas, including cancerous and viral lesions, (ii) immunomodulators, such as cytokines, and optionally (iii) at least one linker joining the two domains or at the terminus of the polypeptide. ... Incept Llc

08/09/18 / #20180222958

Lymphotoxin-beta receptor-binding agents, targeting antibodies, and uses thereof

Polypeptides, agents, and molecules that bind lymphotoxin-beta receptor (ltβr) and/or tumor-associated antigens are disclosed. The polypeptides, agents, or molecules may include, without limitation, fusion or single-chain lymphotoxin-αββ polypeptides and homodimer and heterodimer molecules comprising the lymphotoxin-αββ polypeptides. ... Incept Llc

08/09/18 / #20180222957

Modified cxcl12 polypeptides and uses thereof

The present invention relates to modified cxcl12 polypeptides, modified cxcl12 locked monomers, and cxcl12 locked dimers. The invention further relates to methods for inhibiting signaling through cxcr4 receptors using the polypeptides of the invention.. ... Incept Llc

08/09/18 / #20180222954

Neil3 peptides and vaccines including the same

The present invention provides isolated peptides or the fragments derived from seq id no: 45, which bind to an hla antigen and induce cytotoxic t lymphocytes (ctl). The peptides may include the above mentioned amino acid sequence with substitution deletion, or addition of one, two, or several amino acids sequences. ... Incept Llc

08/09/18 / #20180222953

Sarcomere biosensor and methods of use thereof

Wherein the first and second chromophores are a förster resonance energy transfer (fret) donor-acceptor pair; wherein the first chromophore is a donor chromophore and the second chromophore is an acceptor chromophore, or wherein the first chromophore is an acceptor chromophore and the second chromophore is a donor chromophore; and wherein the polypeptide is capable of integrating into a sarcomere. Certain embodiments of the invention also provide methods of using such polypeptides.. ... Incept Llc

08/09/18 / #20180222952

Progranulin (pgrn) fragments and derivatives for treatment or alleviation of lysosomal storage diseases

The present invention provides peptides, compositions and methods for treatment and alleviation of lysosomal storage diseases and their diagnosis and treatment, including gaucher's disease, and particularly which utilize one or more progranulin (pgrn) derivative or fragment, particularly fragment nd7/pcgin.. . ... Incept Llc

08/09/18 / #20180222951

Brachyury deletion mutants, non-yeast vectors encoding brachyury deletion mutants, and their use

The invention provides brachyury deletion mutant polypeptides, nucleic acids encoding the polypeptides, non-yeast vectors comprising the nucleic acids, non-yeast cells, and methods of use.. . ... Incept Llc

08/09/18 / #20180222943

Antimicrobial peptide for nosocomial infections

A novel antimicrobial peptide is provided having an inhibitory effect on biofilms produced by biofilm-forming bacteria. The peptide is effective against wide range bacterial targets; generates no antimicrobial resistance; agglutinates bacteria cells enhancing the pathogen removal at the infectious focus; promotes biofilm eradication and prevents biofilm development. ... Incept Llc

08/09/18 / #20180222941

Depdc1-derived peptide and vaccine containing same

The present invention provides depdc1-derived epitope peptides having the ability to induce cytotoxic t cells. The present invention further provides polynucleotides encoding the peptides, antigen-presenting cells presenting the peptides, and cytotoxic t cells targeting the peptides, as well as methods of inducing the antigen-presenting cells or ctls. ... Incept Llc

08/09/18 / #20180222940

Mu opioid receptor agonist analogs of the endomorphins

The invention relates to cyclic peptide agonists that bind to the mu (morphine) opioid receptor and their use in the treatment of acute and/or chronic pain. Embodiments of the invention are directed to cyclic pentapeptide and hexapeptide analogs of endomorphin that have (i) a carboxy-terminal extension with an amidated hydrophilic amino acid and (ii) a substitution in amino acid position 2. ... Incept Llc

08/09/18 / #20180222937

Methods for preparation of bile acids and derivatives thereof

The present application relates to a method of preparing compounds of formula (a) or a pharmaceutically acceptable salt, solvate, or amino acid conjugate thereof.. . ... Incept Llc

08/09/18 / #20180222930

Prodrugs of glutamine analogs

And the pharmaceutically acceptable salts thereof, wherein r1, r2, r2′, and x are as defined as set forth in the specification. Compounds having formula (i) are prodrugs that release glutamine analogs, e.g., 6-diazo-5-oxo-l-norleucine (don). ... Incept Llc

08/09/18 / #20180222925

Compounds for treating spinal muscular atrophy

The present invention provides compounds of formula (i) wherein a, b, x, y, r1 and r2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (i), pharmaceutical compositions comprising them and their use as medicaments.. ... Incept Llc

08/09/18 / #20180222922

Radiofluorinated 7-amino-5-thio-thiazolo[4,5-d]pyrimidines for imaging fractalkine receptor (cx3cr1)

Radiofluorinated 7-amino-5-thio-thiazolo[4,5-d]pyrimidines targeting fractalkine receptor (cx3cr1) are disclosed. Methods of imaging cx3cr1-expressing tumors or cells also are disclosed.. ... Incept Llc

08/09/18 / #20180222919

N-alkyl-2-phenoxyethanamines, their preparation and use

The present invention provides a compound having the structure: (structurally represented) wherein r1, r2, r3, r4, and r5 are each independently h, halogen, cf3 or c1-c4 alkyl; r6 is alkyl; a is absent or present, and when present is —c(o)— or —c(o)nh—; b is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, co2h or (c1-c4 alkyl)-co2h, wherein when b is co2h, then a is present and is —c(o)—, or a pharmaceutically acceptable salt thereof.. . ... Incept Llc

08/09/18 / #20180222918

Dopamine d3 receptor antagonists having a bicyclo moiety

The disclosure provides compounds having formula (i), wherein the substituents are as defined herein. The compounds are useful for modulating the dopamine d3 receptor and for treating conditions associated therewith, such as addictions, drug dependency, and psychiatric conditions.. ... Incept Llc

08/09/18 / #20180222908

6,7-dihydropyrazolo[1,5-a]pyrazin-4(5h)-one compounds and their use as negative allosteric modulators of mglur2 receptors

The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5h)-one derivatives as negative allosteric modulators (nams) of the metabotropic glutamate receptor subtype 2 (“mglur2”). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of disorders in which the mglur2 subtype of metabotropic receptors is involved.. ... Incept Llc

08/09/18 / #20180222907

Macrocyclic factor xia inhibitors bearing heterocyclic groups

Or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor xia inhibitors or dual inhibitors of fxia and plasma kallikrein. ... Incept Llc

08/09/18 / #20180222902

Dihydropyrrolopyridine inhibitors of ror-gamma

Pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by rorγ. Also provided are pharmaceutical compositions comprising the novel compounds of formula (i) and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseases or disorders.. ... Incept Llc

08/09/18 / #20180222897

Substituted nicotinimide inhibitors of btk and their preparation and use in the treatment of cancer, inflammation and autoimmune disease

And pharmaceutically acceptable salts, syntheses, intermediates, formulations, and methods of treating diseases including cancer, inflammation, and autoimmune disease mediated at least in part by bruton's tyrosine kinase (btk).. . ... Incept Llc

08/09/18 / #20180222895

Compounds for use in preparing heterocyclic triazole agonists of the apj receptor

Where the definitions of the variables are provided herein.. . ... Incept Llc

08/09/18 / #20180222892

Heterocyclic modulators of lipid synthesis

Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.. . ... Incept Llc

08/09/18 / #20180222890

5-(n-[6,5]-fused bicyclic aryl tetrahydroisoquinolin-6-yl) pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication

Disclosed are compounds of formula i, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting hiv integrase and treating those infected with hiv or aids.. . ... Incept Llc

08/09/18 / #20180222889

Novel substituted glycine derived fxia inhibitors

The present invention provides compounds of formula (i): [insert chemical structure here] (i) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor xia inhibitors or dual inhibitors of fxia and plasma kallikrein. ... Incept Llc

08/09/18 / #20180222888

Compounds useful for treating cancer

Wherein a and a′ independently represent a phenylene group or a pyridylene group; r2 is a hydrogen atom or a (c1-c4)alkyl group; r3 is a 2-pyridyl group, 3-pyridyl group, a 4-pyridyl group, a 2-pyrimidinyl group, a 4-pyrimidinyl group or a 5-pyrimidinyl group; r4 is a carbonyl group or a sulfonyl group; and r5 is a —nh—(ch2)a—nr6r7 group or a 4-methylpiperazinyl group, with a being an integer from 1 to 4, r6 and r7 representing independently a (c1-c4)alkyl group, or r6 and r7 together with the nitrogen atom to which they are linked forming a heterocycle group which is chosen among a 4-methylpiperazinyl group, a morpholino group, a pyrrolidinyl group and a piperidino group; or any one of its pharmaceutically acceptable salt.. . ... Incept Llc

08/09/18 / #20180222886

Vinyl compounds as fgfr and vegfr inhibitors

Fgfr and vegfr inhibitors are provided, and compounds represented by formula (1) or formula (ii) as fgfr and vegfr inhibitors, pharmaceutically acceptable salts or tautomers thereof are specifically disclosed.. . ... Incept Llc

08/09/18 / #20180222885

Muscarinic agonists

This invention relates to compounds that are agonists of the muscarinic m1 receptor and/or m4 receptor and which are useful in the treatment of muscarinic m1/m4 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. ... Incept Llc

08/09/18 / #20180222869

Anticancer drugs including the chemical structures of an androgen receptor ligand and a histone deacetylase inhibitor

A novel class of drugs for treating androgen receptor (ar) positive cancer including prostate cancer and breast cancer are described. The drugs include the chemical scaffolds of a high affinity androgen receptor ligand and a histone deacetylase inhibitor. ... Incept Llc

08/09/18 / #20180222868

Indazole derivatives as modulators of tnf activity

A series of substituted indazole derivatives, being potent modulators of human tnfa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.. . ... Incept Llc

08/09/18 / #20180222864

Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication

Disclosed are compounds of formula i, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting hiv integrase and treating those infected with hiv or aids.. . ... Incept Llc

08/09/18 / #20180222863

Ionizable cationic lipid for rna delivery

Or a pharmaceutically acceptable salt thereof.. . ... Incept Llc

08/09/18 / #20180222862

Novel 3-indol substituted derivatives, pharmaceutical compositions and methods for use

Or pharmaceutically acceptable enantiomers, salts or solvates thereof. The invention further relates to the use of the compounds of formula i as tdo2 inhibitors. ... Incept Llc

08/09/18 / #20180222861

Synthesis of diindolylmethanes and indolo[3,2-b]carbazoles, compounds formed thereby, and pharmaceutical compositions containing them

Described is a method to make diindolylmethanes and indolyl/pyrrolylmethanes, the method includes the steps of contacting an ether comprising an arylpropargyl moiety and an amine-protected, substituted or unsubstituted aniline moiety with a substituted or unsubstituted indol or a substituted or unsubstituted pyrrole, in the presence of a metal-containing catalyst, for a time and at a temperature to cause an annulation/arylation cascade reaction that yields a diindolylmethane or a indolyl/pyrrolylmethane. The resulting compounds are effective to modulate activity of arylhydrocarbon receptors, to inhibit activity of pcsk9, and to stimulate secretion of glucagon-like peptide 1 in mammals.. ... Incept Llc

08/09/18 / #20180222860

Modulators of ror-gamma

Provided are novel compounds of formula i: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by rory. Also provided are pharmaceutical compositions comprising the novel compounds of formula i and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseases or disorders.. ... Incept Llc

08/09/18 / #20180222858

Derivatives of dolastatin 10 and auristatins

The present invention concerns a compound of following formula (i): where: —r1 is h or oh, —r2 is a (c1-c6)alkyl, cooh, coo—((c1-c6)alkyl) or thiazolyl group, —r3 is h or a (c1-c6)alkyl group, and —r4 is: ▪a straight-chain or branched, saturated or unsaturated hydrocarbon group having 1 to 8 carbon atoms substituted by one or more groups chosen from among oh and nr5r6, ▪—(ch2ch2x1)(ch2ch2x2)a2(ch2ch2x3)a3(ch2ch2x4)a4(ch2ch2x5)a5r7, ▪an aryl-(c1-c8)alkyl group substituted by one or more groups chosen from among oh and nr9r10 groups, or ▪a heterocycle-(c1-c8)alkyl group optionally substituted by one or more groups chosen from among (c1-c6)alkyl, oh and nr12r13 groups, or a pharmaceutically acceptable salt, hydrate or solvate thereof, and its uses in particular for the treatment of cancer, pharmaceutical compositions containing the same and the preparation methods thereof.. . ... Incept Llc

08/09/18 / #20180222853

Antitumor compound targeting idh2 mutation and method of use thereof

The present application relates to compounds represented by general formula (i), general formula (ii) or general formula (iii), and pharmaceutically acceptable salts or hydrates thereof, preparation methods thereof, and pharmaceutical compositions thereof. The compounds represented by general formula (i), general formula (ii) or general formula (iii) have inhibitory activities against isocitrate dehydrogenase 2 (idh2), thereby being capable of treating idh2 mutation-induced cancers.. ... Incept Llc

08/09/18 / #20180222838

Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof

Certain compounds, or pharmaceutically acceptable salts or prodrugs thereof, are provided herein. Also provided are pharmaceutical compositions comprising at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein and one or more pharmaceutically acceptable vehicle. ... Incept Llc

08/09/18 / #20180222697

Automated handling of shipping containers and connectors

A system for managing shipping containers and twist lock connectors is described. The system includes multiple stations. ... Incept Llc








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