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Incept Llc patents


Recent patent applications related to Incept Llc. Incept Llc is listed as an Agent/Assignee. Note: Incept Llc may have other listings under different names/spellings. We're not affiliated with Incept Llc, we're just tracking patents.

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Antenna arrangement for an electronic device and an electronic device including same

The current document is directed to computational systems and methods carried out by the computational systems for propagating a combined source-and-receiver wavefield from a first level to a next, second level with respect to depth, time, or another dimension. The methods and systems, to which the current document is directed, apply an efficient complex, combined-source-and-receiver-wavefield propagation operator to a complex combined-source-and-receiver wavefield in order to propagate the complex combined-source-and-receiver wavefield to the next level. . . . . . . . . . . . . . . . . . . . . . . . . A wristworn device including a radio communication device for at least one of receiving signals from and transmitting signals to a communication device external to the wristworn device, the wristworn device including a non-electrically conductive watchcase that itself has an outer surface, a crystal that seals a first end of the watchcase and a case back that seals a second end of the watchcasing; an antenna structure comprising an outer conductive layer and an internal conductive layer electrically coupled to the outer conductive layer; a controller disposed in the casing of the watchcase and operatively coupled to the radio communication device, and wherein the outer conductive layer is electrically coupled to the radio communication device, and the outer conductive layer together with the inner conductive layer function as the antenna for at least one of reception or transmission of signals for the radio communication device. In the disclosed embodiments, the outer conductive layer is preferably disposed on the outer surface of the non-electrically conductive watchcase or embedded within the watchcase.. ... Incept Llc

Method and apparatus for neutral beam processing based on gas cluster ion beam technology

A method of processing a trench, via, hole, recess, void, or other feature that extends a depth into a substrate to a base or bottom and has an opening by irradiation with an accelerated neutral beam derived from an accelerated gas cluster ion beam for processing materials at the base or bottom of the opening.. . ... Incept Llc

Information processing apparatus, object information acquiring apparatus, and information processing method

An information processing apparatus, comprises a first acquiring unit that acquires a photoacoustic image generated base d on an acoustic wave which is generated by light irradiation; a second acquiring unit that acquires an ultrasonic image generated based on a reflected wave of an ultrasonic wave transmitted to the object; a determining unit that determines a high accuracy region that is a region in which information is acquired with at least a predetermined accuracy in the photoacoustic image; an input unit that accepts a specification of a region of interest (roi) on the ultrasonic image; and a displaying unit that displays the ultrasonic image and the photoacoustic image corresponding to the roi, wherein when the inputting unit accepts the specification of the roi, the displaying unit displays the position of the high accuracy region on the ultrasonic image in a superimposed state.. . ... Incept Llc

Image presenting apparatus, optical transmission type head-mounted display, and image presenting method

A display portion 318 includes a plurality of display surfaces corresponding to a plurality of pixels within an image as a target of display, and the display surfaces are configured in such a way that positions thereof in a direction vertical to the display surfaces are made changeable. A convex lens 312 presents a virtual image of an image displayed on the display portion 318 to a field of vision of a user. ... Incept Llc

Transmitting and receiving device for optical cable and alignment method thereof

Embodiments according to the present disclosure relate to an optical transmitting device and an optical receiving device which can minimize the alignment error between the light source and the photodetector on the substrate, miniaturize the devices, and require no separate guide member reducing manufacturing costs, while satisfying the design requirements for sub-miniaturization, and performing optical transmission and reception more efficiently.. . ... Incept Llc

Optical element, and optical element-equipped article

A concavo-convex structure forming layer with a concavo-convex structure on one surface; and a light-reflecting layer on at least part of a surface of the concavo-convex structure. In the optical element, the concavo-convex structure forming layer includes a unit group made up of a plurality of units whose concavo-convex structures are different from each other; each of the units has a flat portion and either a plurality of convexities or a plurality of concavities, with an upper surface of each convexity or a bottom surface of each concavity being substantially parallel to a surface of the flat portion; the convexities or the concavities adjacent to each other have center-to-center distances that are not constant; the convexities or the concavities have a constant height or depth; and in the unit group, units having an identical concavo-convex structure are not arrayed at a pitch of less than 150 μm.. ... Incept Llc

Process and system for enhanced depth penetration of an energy source

The method for enhanced depth penetration of energy into a formation may include mechanically stimulating the formation at a first frequency to induce mechanical stress in the formation and directing electromagnetic radiation towards the formation while mechanically stimulating the formation.. . ... Incept Llc

Distance measurement device

A distance measurement device includes: a pulse light emitter that emits pulse light to a measurement target; an optical sensor that receives reflected light which is the pulse light reflected by the measurement target; and a controller that controls a light emission timing of the pulse light emitted by the pulse light emitter, and determines a distance to the measurement target, from a light reception timing of the reflected light detected by the optical sensor. The controller sets the light emission timing in each of n periods (n being a natural number less than k) selected randomly from continuous k periods (k being a natural number greater than or equal to 2) to a timing that is delayed by a random first time from a start time of the period.. ... Incept Llc

Radio altimeter

A radio altimeter includes a voltage controlled oscillator outputting a radio frequency signal through a forward path in a direction from the voltage controlled oscillator to a radio frequency antenna, a path extending unit positioned in the forward path to receive the radio frequency signal to delay the radio frequency signal to generate a delayed radio frequency signal. The radio frequency antenna transmits the delayed radio frequency signal to ground and receives the delayed radio frequency signal reflected from the ground. ... Incept Llc

Liquid dispenser and method of use

Fraction collector dispensers and methods of using such dispensers are provided. In one embodiment, the dispenser includes an inlet for receiving liquid from a liquid source, wherein the inlet is in fluid communication with an outlet from which liquid is dispensed into a receptacle; and a reservoir in fluid communication with a flow path between the inlet and outlet, wherein the reservoir is configured to receive liquid during movement of the dispenser between receptacles or during movement of receptacles between dispense positions and to receive pressurized air or gas to empty liquid out of the reservoir before or after movement of the dispenser or receptacles, wherein the dispenser is moveable between a first receptacle and a second receptacle or the receptacles are moveable between dispense positions.. ... Incept Llc

Liquid dispenser

Fraction collector dispensers and methods of using such dispensers are provided. In one embodiment, the dispenser includes an inlet for receiving liquid from a liquid source, wherein the inlet is in fluid communication with an outlet from which liquid is dispensed into a receptacle; and a reservoir in fluid communication with a flow path between the inlet and outlet, wherein the reservoir comprises trapped air therein and is configured to receive liquid during movement of the dispenser between receptacles or during movement of receptacles between dispense positions, wherein the dispenser is moveable between a first receptacle and a second receptacle or the receptacles are moveable between dispense positions.. ... Incept Llc

Role of citrullination in diagnosing diseases

Provided herein are methods and markers for diagnosing cardiovascular disease and/or neurodegenearative diseases in a subject. The methods include obtaining a biological sample from a subject in need of diagnosis and detecting the amount of a citrullinated protein or a citrullinated peptide in the biological sample obtained from said subject.. ... Incept Llc

Mass defect-based multiplex dimethyl pyrimidinyl ornithine (dipyro) tags for high-throughput quantitative proteomics and peptidomics

The use of mass defect signatures to impart millidalton mass differences between isotopically labeled peptides at the ms1-level allows multiplex quantification without the increased mass spectral complexity that occurs with mass difference approaches. Provided herein is a mass defect-based chemical tag, dimethyl pyrimidinyl ornithine (dipyro), that is compact and easy to synthesize at high purity in few steps using commercially available starting materials. ... Incept Llc

Methods for enriching glycopeptides for global analysis of glycoproteins

Compositions and methods for enriching glycocompounds are disclosed which can comprise a glycocompound bound to a boronic acid compound which can be conjugated to a dendrimer.. . ... Incept Llc

10/18/18 / #20180299461

Identification of glycosylation forms

The present teachings relate to methods, systems, and kits for analyzing a sample containing a glycopeptide of interest that can subject the glycopeptide of interest to a plurality of parallel deglycosylation reactions that differentially cleave the glycan, with the various products resulting from the deglycosylation reactions being differentially labeled (e.g., with isobaric and/or isomeric labeling reagents) to thereby produce labeled glycopeptides or labeled fragments of the glycopeptides. The products of the various deglycosylation reactions can then be mixed together and subject to lc-ms/ms using a single injection of the mixture. ... Incept Llc

10/18/18 / #20180299460

Protein sequencing methods and reagents

Described are optical methods and reagents for sequencing polypeptides. A probe that exhibits different spectral properties when conjugated to different n-terminal amino acids is conjugated to the n-terminal amino acid of a polypeptide. ... Incept Llc

10/18/18 / #20180299458

Plasmonic nanoparticles and lspr-based assays

Compositions, methods, devices, and systems are described for performing single-step, homogenous, localized surface plasmon resonance (lspr)-based plasmonic assays having exceptional assay sensitivity and extremely low limits of detection (lods). Ag/au core/shell nanoparticles are described, which may be used with lspr sensors to develop single-step, homogeneous, lspr-based assays.. ... Incept Llc

10/18/18 / #20180299457

High-throughput fluorescence polarization microorganism screening assay

The present disclosure provides a high-throughput fluorescence polarization microorganism screening assay for a metabolite produced by a microorganism. The metabolite is detected using competition with a fluorescent reporter for a receptor that binds both the metabolite and the reporter. ... Incept Llc

10/18/18 / #20180299451

Tpm4-alk fusion protein and composition for diagnosing cancer

Result: a tropomyosin 4 (tpm4)-anaplastic lymphoma receptor tyrosine kinase (alk) fusion protein, which is not expressed in a normal gastric tissue, but expressed only in a gastric cancer tissue, is identified. As a result identified by the tpm4 antibody, a high-molecular tpm4 band is present only in a gastric cancer tissue.. ... Incept Llc

10/18/18 / #20180299432

Profiling peptides and methods for sensitivity profiling

The present disclosure is generally directed to profiling peptides, compositions, and kits, as well as methods of use thereof. The profiling peptides comprise an mcl-1 binding domain, and optionally a cellular uptake moiety. ... Incept Llc

10/18/18 / #20180299429

Genetically encoded calcium indicators and methods of use

Genetically encoded calcium indicator (geci) polypeptides and the nucleic acid molecules encoding such polypeptides are provided. In addition, methods of using such nucleic acids and polypeptides in methods of screening for agonists or antagonists of g-protein coupled receptor (gpcr) or ion channels and methods of monitoring neural activity also are provided.. ... Incept Llc

10/18/18 / #20180299427

Detection of acute myeloid leukaemia

The present invention relates to diagnostic screens, antibodies, methods and kits for detection/prognosis of acute myeloid leukaemia. The diagnostic screen detects the presence (+) or absence (−) of the cell surface polypeptide markers i) cd34+; ii) cd45ra+; and iii) cd90− and/or cd123+. ... Incept Llc

10/18/18 / #20180299399

Electrochemical assay for a protein analyte

There is described herein a method for the electrochemical quantification of a protein analyte in sample, comprising: providing one or more electrode(s), each comprising at least one peptide attached to its surface, the peptide being the protein or a fragment thereof; contacting the sample and electrode with an antibody in the presence of a redox reporter, wherein the antibody is capable of binding to each of the protein analyte and the peptide on the electrode; measuring an electrochemical signal generated by the redox reporter when a potential is applied; quantifying the protein analyte by comparing the electrochemical signal generated with a control, wherein the electrochemical signal is indirectly proportional to the amount of protein analyte in the sample.. . ... Incept Llc

10/18/18 / #20180299384

Method for acquiring a spectrum

The invention is an iterative method for acquiring a spectrum of a particle that is subjected to an illumination. It may in particular be a raman spectrum. ... Incept Llc

10/18/18 / #20180299365

Cytometric method and cytometer unit

In the case of a cytometer unit (1) comprising a receptacle (2), which is configured for the insertion of an exchangeable sample carrier (3) and in which an optical path (4) for carrying out a cytometric measurement is implemented, it is proposed to bleach the sample carrier (3) in a region (10) around a sensitive region (18) predefined by a detector arrangement (8) and/or to alter a position of the optical path (4) on the inserted sample carrier (3) using an alteration means (16).. . ... Incept Llc

10/18/18 / #20180299359

Additive manufacturing test feature including powder sampling capsule

A test feature is disclosed that is formed during metal powder additive manufacturing of a production part. The test feature may include a metal powder sample capsule including a chamber for capturing unfused powder from the metal powder additive manufacturing, and a removable cap closing an end of the chamber. ... Incept Llc

10/18/18 / #20180299357

Cell-based composite materials with programmed structures and functions

The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. ... Incept Llc

10/18/18 / #20180299353

Device and method for the analysis of tyres

Device and method for analysis of tyres are presented. The device includes a support frame, a flange, and first/second image acquisition systems. ... Incept Llc

10/18/18 / #20180299352

Tyre condition analysis

The condition of a tyre (5) on a wheel (2) is assessed while the wheel (2) is mounted on a vehicle (1) and while the vehicle (1) is moving. As the vehicle (1) moves, the tyre (5) rotates and moves longitudinally along a path of movement. ... Incept Llc

10/18/18 / #20180299316

Water level sensor

A first electrode is provided to a side wall of a container, and has a width that increases according to an increase in the depth. A second electrode is provided to the side wall of the container, and has a width that reduces according to an increase in the depth. ... Incept Llc

10/18/18 / #20180299282

Mobile device application that enables efficient navigation to urgent care facility based on triage time and insurance

A system and method for providing a mobile device application that may enable efficient navigation to urgent care facilities, wherein the navigation may be online or offline, wherein selection of the urgent care facility may depend on criteria that may include distance from current location, acceptance of the user's insurance and wait time at the urgent care facility.. . ... Incept Llc

10/18/18 / #20180299262

Device for optical 3d measuring of an object

The invention relates to a device for optical 3d measurement of an object using an optical depth-scanning measurement method, comprising at least two light sources, at least two optical means for producing textured patterns and at least one recording means. A first pattern is produced with the aid of a first optical means and projected onto the object to be recorded as a first projection beam. ... Incept Llc

10/18/18 / #20180299258

Apparatus and methods for distance estimation using multiple image sensors

Data streams from multiple image sensors may be combined in order to form, for example, an interleaved video stream, which can be used to determine distance to an object. The video stream may be encoded using a motion estimation encoder. ... Incept Llc

10/18/18 / #20180299151

Multi-function thermostat with intelligent ventilator control for frost/mold protection and air quality control

An hvac system within a building including a ventilator, a number of sensors, and a control device. The control device has a processor that is configured to receive a request to operate the ventilator. ... Incept Llc

10/18/18 / #20180299131

Fuel flow rate setting method, device for implementing said method, and gas turbine plant provided with said device

A gas turbine fuel flow rate setting device includes a flow rate ratio computing unit and a flow rate computing unit. The flow rate ratio computing unit accepts a parameter having a correlation with a gas turbine output, and uses a predetermined flow rate ratio relationship between the parameter and a fuel flow rate ratio between a plurality of premixing nozzle groups to determine a fuel flow rate ratio corresponding to the accepted parameter. ... Incept Llc

10/18/18 / #20180299063

Overhead mounting system for daisy-chained devices

The struggle to organize many tools and miscellaneous items of greatly varying shapes and sizes has led to some innovation in garage storage systems. However, most systems are based on the similar concept of creating an overhead floor on which to store things. ... Incept Llc

10/18/18 / #20180299055

Leak resistant and serviceable receptacle

A receptacle for conveying fluid is disclosed. The receptacle may include a main body, a spring retainer, a valve seat assembly, a poppet, and a spring. ... Incept Llc

10/18/18 / #20180299011

Pressure ring

A pressure ring includes a first pressure ring fitted in a first ring groove of a piston; and a second pressure ring fitted in a second ring groove of the piston, and positioned between the first pressure ring and an oil ring. The second pressure ring is provided with a groove that extends across a surface of the second pressure ring from an inner peripheral side to an outer peripheral side. ... Incept Llc

10/18/18 / #20180298980

Low frequency torsional vibration damper having a formed hub

A low frequency torsional vibration damper has an annular inertia member defining an annular recess for receiving an elastomeric o-ring in a radial outer surface or a radial inner surface thereof and defining opposing annular recesses for receiving elastomeric o-rings, one each, in the top and bottom surfaces thereof, an elastomeric o-ring seated in each annular recess, and a hub defining an annular receptacle with opposing sidewalls that each comprise a plurality of spaced apart tabs permanently deformed against the plurality of elastomeric o-rings, thereby operatively coupling the hub to the inertia member for rotation together. When the inertia member defines the outer diameter of the torsional vibration damper, the hub is mountable on a shaft, and when the inertia member defines the inner diameter of the torsional vibration damper, the hub is mountable inside a shaft.. ... Incept Llc

10/18/18 / #20180298959

Haptic operating device with a rotating element and method for operating electronic equipment with the haptic operating device

Electronic devices, such as consumer electronics devices and constrol systems in vehicles are controlled by way of a haptic operating device with a rotating unit. Selectable menu items are displayed on a display unit, and a menu item is selected by rotating the rotating unit. ... Incept Llc

10/18/18 / #20180298948

Bearing arrangement

The disclosure relates to a bearing arrangement, having a metallic bearing receptacle with a bearing socket, a rubber/metal bearing being pressed into the bearing socket, at least one recess being configured in an inner circumferential face of the bearing socket and/or in the outer circumferential face of the outer sleeve, and the rubber/metal bearing having a metallic outer sleeve which is pressed with an interference fit into the bearing socket.. . ... Incept Llc

10/18/18 / #20180298888

Hydraulic machine and reversible metering pump equipped with such a machine

A hydraulic machine includes: a casing; a differential piston having an upper ring and a lower base, sliding reciprocally in the casing and a cylindrical housing inside the envelope, separating two chambers of the casing; a hydraulic switch conveying liquid to/from the chambers, the switch controlled by movement of the piston and including at least one rod acting on a distribution member that includes an upper valve cooperating with a first seat in the upper ring of the piston and at least one lower valve cooperating with a second seat in the lower base of the piston; and a trigger causing, at the end of the stroke, a sudden change in the position of the switch to reverse the stroke. The lower and upper valve seats accept upper and lower frustoconical portions and a lower frustoconical portion tapering in opposite directions. ... Incept Llc

10/18/18 / #20180298868

Electric starting system for an internal combustion engine

An electric starting system for an internal combustion engine is provided. The starting system includes a rechargeable battery, a battery receiver, and a starter motor. ... Incept Llc

10/18/18 / #20180298766

Gas turbine blade assembly having retainer assembling structure, and gas turbine having same

A gas turbine blade assembly, which is as an assembly provided with a plurality of gas turbine blades on an outer circumferential surface of a rotating disk along a circumferential direction to be spaced apart from each other at predetermined intervals, includes: a retainer insertion hole provided in a blade-fixing end, and depressed by a predetermined depth to correspond to a lower end of a retainer; a retainer coupler provided at a lower end of each of the gas turbine blades, and depressed by a predetermined depth to correspond to an upper end of the retainer; and a coupling member coupled at a location adjacent to the retainer coupler to couple the retainer and each of the gas turbine blades together.. . ... Incept Llc

10/18/18 / #20180298762

Reduced drag system for windmills, fans, propellers, airfoils, and hydrofoils

Airfoil and hydrofoils systems with structures having a surface texture defined by fractal geometries are described. Raised portions or fractal bumps can be included on the surfaces, forming a surface texture. ... Incept Llc

10/18/18 / #20180298741

Process and system for enhanced depth penetration of an energy source

A method for enhanced depth penetration of energy into a formation may include mechanically stimulating proppant in proppant-containing fractures in the formation at a first frequency to induce mechanical stress in the proppant and directing electromagnetic radiation at a second frequency into the proppant-containing fractures of the formation while mechanically stimulating the proppant, wherein the first frequency and the second frequency are the same or different and wherein the proppant includes silica.. . ... Incept Llc

10/18/18 / #20180298690

Rotary gate

Methods and systems are disclosed to facilitate a rotary gate controller moving from one state to another in a manner wherein the gate controller uses the state condition to determine if an exit is taking place when an entry request has been sent. Once such an occurrence is determined to exist, the mid will send an exit request allowing the exiting customer to continue through the gate. ... Incept Llc

10/18/18 / #20180298659

Shower door guide assembly

A shower door guide assembly is provided with a pair of spaced apart brackets. Each bracket has a receptacle formed therein. ... Incept Llc

10/18/18 / #20180298643

A magnetic lock mechanism

A magnetic lock has a barrel and keyway, the barrel when rotated unlocking the lock. Locking element cavities each contain a moveable locking element such as a ball, movable in response to a magnetic field applied by a magnetic key. ... Incept Llc

10/18/18 / #20180298622

Densified foam core (dfc) tile with imitation grout line

A tile that may be used as a covering on a floor, wall, or ceiling surface comprises at least a top section and a core layer may be made from a densified foam material. In most embodiments, but not all, the top section comprises a polyvinyl chloride layer, and may also comprise a wear layer and/or a decorative layer. ... Incept Llc

10/18/18 / #20180298621

Densified foam core (dfc) tile with imitation grout line

A tile that may be used as a covering on a floor, wall, or ceiling surface comprises at least a top section and a core layer may be made from a densified foam material. In most embodiments, but not all, the top section comprises a polyvinyl chloride layer, and may also comprise a wear layer and/or a decorative layer. ... Incept Llc

10/18/18 / #20180298596

Temperature monitoring device for shower system

A shower system includes a receptacle connected to an inlet tube for receiving a fluid, a temperature detector engaged in the receptacle for detecting a temperature of the fluid, a showering device attached to the receptacle, a container is connected to the receptacle for receiving the fluid from the receptacle, and connected to the showering device, a showering head is connected to the container, and a control valve is engaged in the container for controlling the fluid to flow out through either the showering device or the showering head selectively. The temperature detector monitors the temperature of the fluid flowing out through either the showering device or the showering head.. ... Incept Llc

10/18/18 / #20180298585

Cabin of working machine and working machine having cabin

A cabin includes: a panel disposed on a side of an operator seat, the panel including: a plurality of cross members extending in a first direction; and a plurality of transverse members intersecting with the plurality of cross members each other and extending in a second direction; a glass panel disposed on a side of the panel; a window frame disposed on the glass panel; a window panel disposed on the window frame, the window panel being configured to move in the first direction or in the second direction; a projecting member disposed on a side of the window panel, the side being an identical side to the operator seat, the projecting member being configured to move together with the window panel; and a guide portion configured to accept insertion of the projecting member and to limit a moving distance of the window panel.. . ... Incept Llc

10/18/18 / #20180298581

Environmental amelioration with improved ec fiber bags and processes particularly useful for mitigation of erosion in challenged areas

Improved ec types of fiber bags drives minimum negative environment impact with installation, up to at least tertiary level adverse water or rain events do not substantially degrade the mechanical integrity or erosion mitigating impact of structures or landscapes ameliorated on a long term basis or mitigated from hazard to acceptable levels and compliance with regulatory and cost structures for said system are maintained more efficiently than known systems, as maintained for examples in special purpose processing or computing media.. . ... Incept Llc

10/18/18 / #20180298573

Roadway sweeper with multiple sweeping modes

A roadway or pavement sweeper with multiple sweeping modes for the removal of debris from a swept surface may, in some embodiments, include a sweeper vehicle having a pair of side-brooms independently movable between a retracted and extended position for sweeping debris into an area therebetween and at least one material-transfer broom to sweep a portion of the debris accumulated between the side-brooms as the vehicle moves in its direction of travel. A fan-driven suction-inlet may be provided at or adjacent each side of the vehicle. ... Incept Llc

10/18/18 / #20180298569

Truck position control system for milling operations

A control system (40) is disclosed for a mobile machine (10) configured to transfer material into a receptacle (18). The control system may include a first sensor (44) configured to generate a first signal indicative of one of a speed of the mobile machine and a distance between the mobile machine and the receptacle, a display system (56) having at least one display device (58) configured to show information relating to one or more of the mobile machine and the receptacle to an operator of the receptacle, and a controller electronically connected to the first sensor and the display system. ... Incept Llc

10/18/18 / #20180298494

Graphite susceptor

Embodiments described herein include a susceptor for semiconductor processing including an oriented graphite plate that may have a thickness of at least 1 mm. The susceptor may have a support member, and the oriented graphite plate may be disposed on the support member. ... Incept Llc

10/18/18 / #20180298426

Systems and methods for performing assays

A processing module is configured to extend the capabilities of an analyzer configured to process substances within each of a plurality of receptacles. The module includes a container transport configured to transport a container from a location within the processing module to a location within the analyzer that is accessible to a substance transfer device of the analyzer. ... Incept Llc

10/18/18 / #20180298422

Polypeptide specifically binding to taq dna polymerase and use thereof

The present invention discloses a novel polypeptide capable of binding taq dna polymerase, a polynucleotide encoding the polypeptide, a recombinant vector comprising the polynucleotide, a cell having the recombinant vector introduced therein, a method of producing the polypeptide using the recombinant cell, and a hot-start pcr composition comprising the polypeptide. The polypeptide of the present invention is capable of binding specifically to taq dna polymerase to inhibit the activity of the polymerase, and thus may be effectively used in hot-start pcr using taq dna polymerase.. ... Incept Llc

10/18/18 / #20180298417

Rapid preconcentration of viable bacteria using magnetic ionic liquid for pcr amplification and culture-based diagnostics

In this disclosure, transition and rare earth metal-based magnetic ionic liquids (mils) are successfully prepared in a two-step synthesis and used to extract viable bacteria from a liquid sample. The disclosed mils are extremely hydrophobic mils and were insoluble in aqueous solution at 0.01% (v/v). ... Incept Llc

10/18/18 / #20180298415

Cofactor regeneration system

The present invention relates to cofactor regeneration systems, components and uses thereof and methods for generating and regenerating cofactors. The cofactor regeneration system comprises a first electron transfer component selected from a polypeptide comprising a nadh:acceptor oxido-reductase or nadph:acceptor oxido-reductase, a second electron transfer component selected from a hydrogenase moiety and/or non-biological nanoparticles and an electronically conducting surface. ... Incept Llc

10/18/18 / #20180298407

Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription

The present disclosure provides a dna-targeting rna that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target dna and/or a polypeptide associated with the target dna. The present disclosure further provides site-specific modifying polypeptides. ... Incept Llc

10/18/18 / #20180298406

Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription

The present disclosure provides a dna-targeting rna that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target dna and/or a polypeptide associated with the target dna. The present disclosure further provides site-specific modifying polypeptides. ... Incept Llc

10/18/18 / #20180298402

Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics

Isolated polynucleotides and polypeptides encoded thereby are described, together with the use of those products for making transgenic plants with increased tolerance to abiotic stress (e.g., high or low temperature, drought, flood).. . ... Incept Llc

10/18/18 / #20180298394

Selection in fungi

The present invention relates to methods for constructing a recombinant fungal host cell comprising one or more copies of a polynucleotide construct integrated in its genome, said method comprising transforming a fungal host cell with an integrative polynucleotide construct comprising a first polynucleotide encoding a selectable marker, wherein the first polynucleotide, a 5′ untranslated region thereof and/or a riboswitch operably linked therewith comprises a spliceosomal intron which has 5 nucleotides or less between its branch site and its acceptor site; and a second polynucleotide encoding a polypeptide of interest; as well as suitable polynucleotide constructs, resulting fungal host cells and methods of manufacture.. . ... Incept Llc

10/18/18 / #20180298390

Novel genetic code and translation system for producing polypeptide, and method for producing polypeptide

(ii) a trna having an anticodon to a codon after interchange and recognized by an aminoacyl-trna synthetase corresponding to an amino acid encoded by a codon before the interchange, or a nucleic acid encoding the trna, the amino acids, and the aminoacyl-trna synthetase or a nucleic acid encoding the aminoacyl-trna synthetase.. . ... Incept Llc

10/18/18 / #20180298388

Cytotoxic t cell response modifiers

The present invention relates to a compound selectively binding to a sensory receptor or selectively altering the expression of a sensory receptor for use in a method for treating or preventing a disease associated with a pathologic cellular cytotoxic t cell (ctl) response. Further, the invention relates to means for detecting a sensory receptor for use in a method for diagnosing cellular resistance against ctl response in a patient. ... Incept Llc

10/18/18 / #20180298383

Peptide oligonucleotide conjugates

Oligonucleotide analogues conjugated to carrier peptides are provided. The disclosed compounds are useful for the treatment of various diseases, for example diseases where inhibition of protein expression or correction of aberrant mrna splice products produces beneficial therapeutic effects.. ... Incept Llc

10/18/18 / #20180298379

Small interfering rna modification method by combining with isonucleoside modification, terminal peptide conjugation and cationic liposomes, and preparation

Provided is a novel chemical modification method for small interfering rna (sirna). The method is combined with at least two of the three methods of isonucleoside modification, terminal peptide conjugation and cationic liposomes.. ... Incept Llc

10/18/18 / #20180298376

Isolating traffic-enhancing mutants of drug delivery protein

The invention relates to methods for isolating traffic-enhancing mutants of drug delivery proteins. In one embodiment, the invention provides a carrier for delivering a therapeutic agent to an organelle, comprising a polypeptide encoded by a mutant penton base gene. ... Incept Llc

10/18/18 / #20180298367

Suppression of itch

The invention provides a polypeptide, for use in suppressing or treating itch, wherein the polypeptide comprises: a non-cytotoxic protease, which protease is capable of cleaving a snare protein in an itch-specific drg neuron or a pruriceptor; a targeting moiety (tm) that is capable of binding to a binding site on the itch-specific drg neuron or a pruriceptor, which binding site is capable of undergoing endocytosis to be incorporated into an endosome within the itch-specific drg neuron or a pruriceptor, and wherein said itch-specific drg neuron or a pruriceptor expresses said snare protein; and a translocation domain that is capable of translocating the protease from within an endosome, across the endosomal membrane and into the cytosol of the itch-specific drg neuron or a pruriceptor; with the proviso that the polypeptide is not a clostridial neurotoxin (holotoxin) molecule.. . ... Incept Llc

10/18/18 / #20180298365

Polypeptides having lysozyme activity and polynucleotides encoding same

The present invention relates to isolated polypeptides having lysozyme activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.. ... Incept Llc

10/18/18 / #20180298364

Pullulanase variants and polynucleotides encoding same

The present invention relates to pullulanase variants comprising substitutions of the parent pullulanase at one or more positions corresponding to positions 393, 143, 150, 243, 244, 345, 346, 368, 370, 373, 381, 382, 385, 387, 402, 429, 430, 431, 432, 456, 486, 492, 610, 624, 631, 632, 665 and 699 of the polypeptide of seq id no: 3. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.. ... Incept Llc

10/18/18 / #20180298362

Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same

The present invention relates to isolated polypeptides having cellulolytic enhancing activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.. ... Incept Llc

10/18/18 / #20180298361

Endoglycosidase mutants for glycoprotein remodeling and methods of using it

A mutant of endos2 includes one or more mutations in the sequence of a wild-type endos2 (seq id no:1), wherein the one or more mutations are in a peptide region located within residues 133-143, residues 177-182, residues 184-189, residues 221-231, and/or residues 227-237, wherein the mutant of endos2 has a low hydrolyzing activity and a high tranglycosylation activity, as compared to those of the wild-type endos2. A method for preparing an engineered glycoprotein using the mutant of endos2 includes coupling an activated oligosaccharide to a glycoprotein acceptor. ... Incept Llc

10/18/18 / #20180298359

Intracellular protein delivery

A secretion signal peptide sequence (sp) in combination with a cleavage inhibition sequence (cis) fused to a structural gene sequence in a recombinant expression system can be used to express a full length protein with an sp in a cell. Such a fusion protein may be purified to homogeneity from a membrane fraction of the cell. ... Incept Llc

10/18/18 / #20180298355

Transaminase polypeptides

The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.. ... Incept Llc

10/18/18 / #20180298352

Polypeptide for the enzymatic detoxification of zearalenone, isolated polynucleotide, and associated additive, use and method

The invention relates to a polypeptide for the enzymatic detoxification of zearalenone, said polypeptide being a monooxygenase which converts the keto group in position 7 of zearalenone into an ester group, the monooxygenase in particular being an amino acid sequence selected from the group comprising sequence id no. 1, 2 and 3 or a functional variant thereof. ... Incept Llc

10/18/18 / #20180298338

T cells with increased immunosuppression resistance

This invention relates to the treatment of cancer in an individual by administration of a population of modified t cells that express a recombinant camp phosphodiesterase (pde) or a fragment thereof and an antigen receptor which binds specifically to cancer cells in the individual. Populations of modified t cells and methods of producing populations of modified t cells are provided, along with pharmaceutical compositions and methods of treatment.. ... Incept Llc

10/18/18 / #20180298336

T cell receptor-deficient t cell compositions

The invention is directed to modified t cells, methods of making and using isolated, modified t cells, and methods of using these isolated, modified t cells to address diseases and disorders. In one embodiment, this invention broadly relates to tcr-deficient t cells, isolated populations thereof, and compositions comprising the same. ... Incept Llc

10/18/18 / #20180298326

Method of nociceptor differentiation of human embryonic stem cells and uses thereof

The present invention relates to the field of stem cell biology, in particular the lineage specific differentiation of pluripotent or multipotent stem cells, which can include, but is not limited to, human embryonic stem cells (hesc), human induced pluripotent stem cells (hipsc), somatic stem cells, cancer stem cells, or any other cell capable of lineage specific differentiation. Specifically described are methods to direct the lineage specific differentiation of hesc and/or hipsc to nociceptors (i.e. ... Incept Llc

10/18/18 / #20180298250

Method for making quick drying adhesive available for architectural use under low temperature

A method includes preparing a solvent, adding the solvent into a mixture to dissolve the mixture and to form a mixing solution, adding a filler and an additive into the mixing solution, and using a three-shaft mixer to stir and blend the solvent, the filler, the mixing solution and the additive to form a sticky quick drying adhesive. The temperature is controlled under 40° c. ... Incept Llc

10/18/18 / #20180298226

Process for preparing transparent/semi-transparent color dispersions and the color dispersions made thereof

This invention relates to a process for preparing color dispersions comprising a first step of contacting water, a first colorant, and a polysaccharide selected from methylcellulose, hydropropylmethylcellulose, hydroxyethylmethylcellulose, hydroxybutylmethylcellulose, hydroxyethylethylcellulose, and the mixture thereof, to form a first colorant dispersion; a second step of contacting the first colorant dispersion with a protective composition comprising an aqueous dispersion of polymer particles, clay, and a peptizing agent to form a dispersion of protected first colorant particles; an optional third step of repeating the first step and the second step with a second colorant that is different from the first colorant to form a dispersion of protected second colorant particles; and an optional fourth step of mixing the dispersions of protected first and second colorant particles to form a multi-color dispersion. This invention also relates to a color dispersion comprising the first colorant dispersion, and a color coating comprising the color dispersion.. ... Incept Llc

10/18/18 / #20180298160

Polytetrafluoroethylene aqueous dispersion

To provide a polytetrafluoroethylene aqueous dispersion which is excellent in mechanical stability, while being not susceptible to foaming. The polytetrafluoroethylene aqueous dispersion comprises: 15 to 70 mass % of polytetrafluoroethylene particles having an average primary particle size of 0.1 to 0.5 μm; 0.1 to 20,000 ppm, to the mass of the polytetrafluoroethylene particles, of a fluorinated emulsifier selected from c4-7 fluorinated carboxylic acids which may have an ether oxygen atom, and salts thereof; 1 to 20 parts by mass, per 100 parts by mass of the ptfe particles, of a nonionic surfactant represented by r1—o-a-h (wherein r1 is a c8-18 alkyl group, and a is a polyoxyalkylene chain); 0.01 to 3.0 parts by mass, per 100 parts by mass of the polytetrafluoroethylene particles, of a compound represented by the formula (2) (wherein r is a c2-4 alkyl group, n is 1 or 2, and each of m1 and m2 is an average repeating number of oxyethylene groups, with (m1+m2) being 1 to 6); and water.. ... Incept Llc

10/18/18 / #20180298134

Composition for soft mold and soft mold manufactured by using the composition

A composition for a soft mold according to an embodiment of the inventive concept may manufacture a soft mold having good durability and release properties by including at least one multifunctional acrylate monomer, at least one photoinitiator, and a siloxane compound, and may improve productivity in the manufacture of an optical member by using the soft mold.. . ... Incept Llc

10/18/18 / #20180298109

Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics

This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against vsig1, ildr1, loc253012, ai216611, c1orf32 or fxyd3 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. ... Incept Llc

10/18/18 / #20180298103

Monoclonal antibodies directed to peptide in the context of mhc and methods of making and using monoclonal antibodies

Phycoerythrin (pe) and peptide:mhcii (p:mhcii) reactive monoclonal antibodies; methods to generate monoclonal antibodies including, for example, peptide:mhc (p:mhc) reactive monoclonal antibodies; compositions including monoclonal antibodies; and uses thereof.. . ... Incept Llc

10/18/18 / #20180298100

Combination therapy for the treatment of cancer

This invention relates to a pharmaceutical composition that comprises a first molecule that specifically binds her2/neu and a second molecule that specifically binds a cell-surface receptor (or its ligand) that is involved in regulating an immune checkpoint (or the ligand thereof). The invention particularly relates to the embodiment wherein the second molecule binds to pd-1. ... Incept Llc

10/18/18 / #20180298099

T-cell recepter (tcr) targeting therapies for immune-mediated adverse drug reactions (adrs) and other conditions

The present invention provides methods and compositions for treating immune mediated adverse drug reactions using anti-αβ tcr antibodies and fragments thereof. The adverse drug reactions treated according to the invention include severe cutaneous adverse reactions, idiosyncratic liver injury, and idiopathic drug-induced liver disease. ... Incept Llc

10/18/18 / #20180298098

Immunotherapeutic targeting of placental-like chondroitin sulfate using chimeric antigen receptors (cars) and immunotherapeutic targeting of cancer using cars with split-protein binding systems

The present invention relates to polypeptides comprising conditionally active chimeric antigen receptor (car) and a split-protein binding system, a var2csa polypeptide, or any other targeting agent. The present invention further relates to poly-peptides comprising var2csa polypeptides or other targeting agent, and a split-protein binding system.. ... Incept Llc

10/18/18 / #20180298089

Chimeric and humanized anti-histone antibodies

The present invention concerns chimeric or humanized antibodies or antigen-binding fragments thereof that comprise specific cdr sequences, disclosed herein. Preferably, the antibodies or fragments comprise specific heavy and light chain variable region sequences disclosed herein. ... Incept Llc

10/18/18 / #20180298087

Humanized monoclonal advanced glycation end-product antibody

A humanized monoclonal antibody that binds to an advanced glycation end-product-modified protein or peptide on a cell comprises a heavy chain and a light chain. The antibody binds a carboxymethyllysine-modified protein or peptide. ... Incept Llc

10/18/18 / #20180298079

Compositions and methods for immunomodulation in an organism

The present invention relates to a therapeutic polypeptide and methods for its creation and use for modulating an immune response in a host organism in need thereof. In particular, the invention relates to the administration to an organism in need thereof, of an effective amount of a pre-coupled polypeptide complex comprising a lymphokine polypeptide portion, for example il-15 (seq id no: 5, 6), il-2 (seq id no: 10, 12) or combinations of both, and an interleukin receptor polypeptide portion, for example il-15ra (seq id no: 7, 8), il-2ra (seq id no: 9, 11) or combinations of both, for augmenting the immune system in, for example, cancer, scid, aids, or vaccination; or inhibiting the immune system in, for example, rheumatoid arthritis, or lupus. ... Incept Llc

10/18/18 / #20180298077

Glucagon-like-peptide-2 (glp-2) analogues

Glp-2 analogues are disclosed which comprise one of more substitutions as compared to h[gly2]glp-2 and which may have the property of an altered glp-1 activity, and their medical use. The analogues are particularly useful for the prophylaxis treatment or ameliorating of the gastro-intestinal associated side effects of diabetes.. ... Incept Llc

10/18/18 / #20180298075

Interferon analogs

The invention relates to the field of medicine. Among others, it relates to biologically active analogs of interferons (ifns) which show less unwanted side-effects and to the therapeutic uses thereof. ... Incept Llc

10/18/18 / #20180298074

Targeted modified tnf family members

The present invention relates to a modified cytokine of the tnf superfamily, with reduced activity to its receptor, wherein said modified cytokine is specifically delivered to target cells. Preferably, said modified cytokine is a single chain variant of the tnf superfamily, even more preferably, one or more of the chains can-y one or more mutations, resulting in a low affinity to the receptor, wherein said mutant cytokine is specifically delivered to target cells. ... Incept Llc

10/18/18 / #20180298073

Modified fgf-21 polypeptides and their uses

Modified fgf-21 polypeptides and uses thereof are provided.. . ... Incept Llc

10/18/18 / #20180298072

Diagnosis of a novel autoimmune disease

Polypeptides including neurochondrin and autoantibodies binding to polypeptides including neurochondrin are provided. Methods for diagnosing or treating diseases associated with neurological symptoms or cancers are also provided. ... Incept Llc

10/18/18 / #20180298070

Peptide compound

Wherein each symbol is as defined herein.. . ... Incept Llc

10/18/18 / #20180298069

Cell lines for screening odorant and aroma receptors

Provided herein is a cell line with improved odorant receptor function comprising an activated endogenous rtp1 gene, which further expresses an rtp1 protein. Further provided herein is a method for specifically activating an endogenous rtp1 gene in a eukaryotic cell using a crispr/cas9 derived technique. ... Incept Llc

10/18/18 / #20180298068

Treatment of cancer using chimeric antigen receptor and protein kinase a blocker

The invention provides compositions and methods for treating diseases associated with expression of a cancer associated antigen as described herein. The invention also relates to chimeric antigen receptor (car) specific to a cancer associated antigen as described herein, vectors encoding the same, and recombinant t cells comprising the cars of the present invention. ... Incept Llc

10/18/18 / #20180298067

Methods for the production of a cosmetic composition comprising leukolectin and uses thereof

The present invention relates to cosmetic compositions comprising polypeptides obtained or obtainable from salmonidae hatching fluid, methods of producing said compositions and their use in various cosmetic applications to the skin, particularly for improving the cosmetic appearance of skin of a mammalian animal.. . ... Incept Llc

10/18/18 / #20180298066

Peptides having reduced toxicity that stimulate cholesterol efflux

The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., apo ai and apo e), and having high selectivity for abca1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. ... Incept Llc

10/18/18 / #20180298065

Protease-resistant streptavidin

The present invention relates to modified streptavidin molecules that are resistant to cleavage by lys-c or other proteases. These modified streptavidin molecules can be produced by chemical modification of natural streptavidin, by chemical synthesis or by genetic engineering. ... Incept Llc

10/18/18 / #20180298063

Engineered influenza antigenic polypeptides and immunogenic compositions thereof

The present invention provides, among other things, a novel and improved method for generating “mosaic” influenza antigenic polypeptides including hemagglutinin (ha) and neuraminidase (na) polypeptides based on unique combination of epitope patterns that maximize exposure to epitopes present across multiple ha or na sequences and therefore improved influenza strain coverage. In particular, the present invention provides engineered h1n1 influenza hemagglutinin (ha) polypeptides that are comprised of novel combinations of protective epitopes and antigenic regions from multiple h1n1 viral strains. ... Incept Llc

10/18/18 / #20180298062

Self-assembled structures composed of monomers of peptide nucleic acid and tunable photonic crystals made therefrom

Ordered structures composed of a plurality of self-assembled peptide nucleic acid (pna) monomers, and processes of generating same are provided. The plurality of pna monomers includes modified pna monomers which are n-protected pna monomers and/or which feature at least one aromatic moiety attached to a backbone, a nucleobase and/or a nucleobase linkage unit of the pna monomer. ... Incept Llc

10/18/18 / #20180298061

Synthetic n-acetyl-muramic acid derivatives and uses thereof

The present invention provides n-acetyl-muramic acid (nam) derivatives having formula i, wherein xa is selected from the group consisting of x1-x59, ya is selected from the group consisting of h, monophosphate, uridine diphosphate and ethyl azide linker prepared from 2-azido-ethanol, and za is selected from the group consisting of oh, an ethylene diamine coupled fluorophore, a peptide and a peptide with an ethylene diamine coupled fluorophore, wherein the peptide is selected from the group consisting of a monopeptide, a dipeptide, a tripeptide and a pentapeptide. Also provided are methods for synthesizing nam derivatives and methods for modulating nod2 in cells, modifying bacterial cell wall or modulating innate immune response by a subject to bacterial cells upon exposure to nam derivatives.. ... Incept Llc

10/18/18 / #20180298060

Cyclopeptide, pharmaceutical or cosmetic composition comprising the same and method for preparing the same

Wherein r1 is defined in the specification. In addition, a pharmaceutical or cosmetic composition comprising the same and a method for preparing the same are also disclosed.. ... Incept Llc

10/18/18 / #20180298059

A new type polypeptide targeting tumours

Provided is a nrgd polypeptide formed by connecting alanine-alanine-asparagine (aan) and a polypeptide containing arginine-glycine-aspartic acid (rgd), wherein the nrgd polypeptide can target tumour vessels, tumour cells and tumour-associated macrophages, and mediate the targeted delivery of tumours.. . ... Incept Llc

10/18/18 / #20180298058

A multi-functional peptide benefiting expression, purification, stabilization and catalytic efficiency of recombinant proteins

The present invention relates to a multi-functional peptide benefiting expression, purification, stabilization and catalytic efficiency of recombinant proteins, which relates to the field of enzyme engineering and protein purification. The present invention provides a self-assembling amphipathic peptide, which fused with proteins including alkaline polygalacturonate lyase (pgl), lipoxygenase (lox) and green fluorescent protein (gfp), which leads to successful purification by the nickel affinity chromatography with recovery rates were 47.01%, 39.01% and 56.1%, respectively. ... Incept Llc

10/18/18 / #20180298057

Compositions and methods for managing respiratory conditions

This disclosure relates to compositions for use in managing respiratory distress and related disorders. In certain embodiments, the disclosure relates to methods of treating or preventing respiratory distress comprising administering an effective amount of a pharmaceutical composition comprising peptides or agents disclosed herein to a subject in need thereof. ... Incept Llc

10/18/18 / #20180298055

Inhibitors of nf kappa-b activity for treatment of diseases and disorders

Peptides and methods of use thereof, are disclosed for use in treating various disease and disorders, including inflammation, pain, oral mucositis, oral lesions, and cancer. The peptides modulate the activity of the transcription. ... Incept Llc

10/18/18 / #20180298053

Antibiotic oligopeptides

Disclosed are methionine mimetics that possess antibiotic properties in prokaryotic cells. These mimetics are coupled to one or more optionally substituted amino acids provided that at least one of the amino acids is phenylglycine, tryptophan, phenylalanine or tyrosine.. ... Incept Llc

10/18/18 / #20180298051

Methods and compositions related to functional polypeptides embedded in heterologous protein scaffolds

The present invention provides methods for generating functional derivatives of effector polypeptides (e.g., hormones and receptor ligands) embedded in a different protein scaffold (e.g., antibody scaffolds). The methods involve modifying the effector polypeptide with a combinatorial library of terminal linker sequences, inserting the modified sequences into the host scaffold, and then selecting functional derivatives from the library of modified polypeptide sequences embedded in the host scaffold. ... Incept Llc

10/18/18 / #20180298043

Alkyne compounds for treatment of complement mediated disorders

Compounds, methods of use, and processes for making inhibitors of complement factor d comprising formula i, or a pharmaceutically acceptable salt or composition thereof, wherein r12 or r13 on the a group is an alkyne (r32) are provided. The inhibitors described herein target factor d and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor d's ability to modulate the classical and lectin complement pathways. ... Incept Llc

10/18/18 / #20180298036

Urea peptoid boric acid compound, pharmaceutical composition thereof, preparation method therefor, and uses thereof

The present invention provides a urea peptidomimetic boronic compound and pharmaceutical compositions thereof, their preparative methods and uses. The compounds are represented by the following formula (1).. ... Incept Llc

10/18/18 / #20180298035

Inhibitors of indoleamine 2,3-dioxygenase

Provided are compounds of formula (i) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and methods for their use in the prevention and/or treatment of hiv; including the prevention of the progression of aids and general immunosuppression.. . ... Incept Llc

10/18/18 / #20180298030

Heterocyclic compounds as inhibitors of platelet aggregation

The present invention provides compounds of formula i: wherein y, aa, w, r3′ r2, r4, r5, r6, r7, x1, x2, x3, x4 and x5 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug or esters or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.. ... Incept Llc

10/18/18 / #20180298028

Deuterated otx-015

This invention relates to novel thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines, and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an inhibitor of binding between an acetylated histone and a bromodomain-containing protein.. ... Incept Llc

10/18/18 / #20180298021

Substituted thiohydantoin derivatives as androgen receptor antagonists

Wherein r1 and g are defined herein.. . ... Incept Llc

10/18/18 / #20180298020

Piperidine derivative and preparation method and pharmaceutical use thereof

The present invention relates to a piperidine derivative and the preparation method and a pharmaceutical use thereof. In particular, the present invention relates to the piperidine derivative as shown by general formula (i) and the preparation method thereof and a pharmaceutical composition containing the same, and the use thereof as an estrogen receptor modulator in the treatment of estrogen receptor mediated or dependent diseases or conditions, the diseases preferably being breast cancer. ... Incept Llc

10/18/18 / #20180298018

Fused tricyclic pyrazole derivatives useful for farnesoid x receptors

A stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators of the activity of farnesoid x receptors (fxr).. . ... Incept Llc

10/18/18 / #20180298015

Pyrazolo[1,5a]pyrimidine derivatives as irak4 modulators

Compounds of formula 0, formula i, and formula ii and methods of use as interleukin-1 receptor associated kinase (irak4) inhibitors are described herein.. . ... Incept Llc

10/18/18 / #20180298013

Aryl hydrocarbon receptor antagonists and uses thereof

The disclosure relates to aryl hydrocarbon receptor antagonists, such as substituted imidazopyridines and imidazopyrazines, as well as methods of expanding hematopoietic stem cells by culturing hematopoietic stem or progenitor cells in the presence of these agents. Additionally, the disclosure provides methods of treating various pathologies in a patient by administration of expanded hematopoietic stem cells. ... Incept Llc

10/18/18 / #20180298011

Pyrazolo[1,5-a]pyrimidines for antiviral treatment

Or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating pneumovirinae virus infections. ... Incept Llc

10/18/18 / #20180298010

Prmt5 inhibitors and uses thereof

Described herein are compounds of formula (a), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting prmt5 activity. ... Incept Llc

10/18/18 / #20180298007

Pyrazolo[1,5-a]triazin-4-amine derivatives useful in therapy

A compound of formula (i), or a pharmaceutically acceptable salt thereof, useful in therapy, in particular in the treatment of a viral infection.. . ... Incept Llc

10/18/18 / #20180298006

Fused tricyclic imidazo pyrazines as modulators of tnf activity

A series of substituted fused tricyclic imidazo pyrazine derivatives and analogues thereof, represented by formula (i), being potent modulators of human tnfa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.. . ... Incept Llc

10/18/18 / #20180298003

Tetracyclic bromodomain inhibitors

Wherein r1, r2, r6, y1, y2, y3, a1, a2, a3, and a4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and aids. Also provided are pharmaceutical compositions comprising one or more compounds of formula (i).. ... Incept Llc

10/18/18 / #20180298002

Nicotinic acetylcholine receptor silent agonists

Derivatives of n,n-diethyl-n′-phenyl-piperazine, a silent agonist of the mammalian α7 nicotinic acetylcholine receptor, are provided. These silent agonists control the desensitization state of the receptor. ... Incept Llc

10/18/18 / #20180298001

Ergoline compounds and uses thereof

Provided herein are ergoline compounds and pharmaceutical compositions thereof. In some embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and pharmaceutical compositions disclosed herein. ... Incept Llc

10/18/18 / #20180297996

Non-selective protease activated receptor 4 ala120thr isoform antagonist

A substance of formula (i) for use as a medicament for the treatment of cardiovascular diseases, wherein r is nitrogen or carbon; r1 is selected from the group consisting of a hydrogen, a trifluoromethyl, a methyloxyphenyl, a phenyl, a c1-c3 phenylalkyl, a halogenated phenyl, a halogenated c1-c3 phenylalkyl, a trifluoromethyloxy, a trifluoromethyl oxyphenyl, and a c1-c3 pyridinylalkyl; r2 is selected from the group consisting of a c1-c3 alkyl alcohol optionally substituted with a c1-c3 alkoxyphenyl, a c1-c3 n-alkylmethanamine, a c1-c3 alkoxymethyl, a c1-c3 phenylalkoxymethyl, a c1-c3 cyclopropylalkoxymethyl, and a methoxyethoxymethyl; and r3 is a phenyl or a methoxypyridinyl; and r4 is selected from the group consisting of a hydrogen, a cyano, a c1-c3 sulfonyl, a nitro, and a trifluoromethyl.. . ... Incept Llc

10/18/18 / #20180297994

Positive allosteric modulators of muscarinic m2 receptor

The present application relates to positive allosteric modulators of the muscarinic m2 receptor, especially to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular disorders and/or renal disorders.. . ... Incept Llc

10/18/18 / #20180297992

Inhibiting agents for bruton's tyrosine kinase

Provided are compounds of formula (i), or pharmaceutically acceptable salts thereof, and methods for their use and production.. . ... Incept Llc

10/18/18 / #20180297990

Dopamine d3 receptor antagonists having a morpholine moiety

The disclosure provides compounds of formula (i) or pharmaceutically acceptable salts thereof: the disclosure also provides processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them, and their use as modulators of dopamine d3 receptors, such as treating substance abuse or psychiatric diseases.. . ... Incept Llc

10/18/18 / #20180297988

Oxa spiro derivative, preparation method therefor, and applications thereof in medicines

The present invention relates to an oxa spiro derivative, a preparation method therefor, and applications thereof in medicines. Particularly, the present invention relates to an oxa spiro derivative represented by formula (i), a preparation method therefor, and a pharmaceutical composition comprising the derivative, applications thereof as an mor receptor agonist, and applications in the preparation of drugs for treating and/or preventing pains and pains-related diseases. ... Incept Llc

10/18/18 / #20180297987

Amino pyrimidine ssao inhibitors

The present invention provides compounds of the formula (i), or a pharmaceutically acceptable salt thereof, where n and r1 are defined herein, methods of treating patients for liver disease, and processes for preparing the compounds.. . ... Incept Llc

10/18/18 / #20180297981

Triazole derivativesas p2y14 receptor antagonists

Described are compounds, which are antagonists of the p2y14 receptor, for example, a compound of formula (i) in which ring a, r1, r2, r3, and n are as described herein. Also provided are dendron conjugates comprising the compounds, and methods of using the compounds, including a method of treating a disorder, such as inflammation, diabetes, insulin resistance, hyperglycemia, a lipid disorder, obesity, a condition associated with metabolic syndrome, and asthma, and a method of antagonizing p214 receptor activity in a cell.. ... Incept Llc

10/18/18 / #20180297977

Novel pan-tam inhibitors and mer/axl dual inhibitors

This invention is in the area of improved therapeutic combinations for and methods of treating selected cancers using selected pyrimidine compounds having pan-tam or mer/axl dual receptor tyrosine kinase inhibitory activity in combination with immune checkpoint inhibitors. In one aspect, an improved treatment for select cancers is disclosed using selected pyrimidine compounds described herein in combination with an immune checkpoint inhibitor, for example, a cytotoxic t-lymphocyte-associated protein 4 (ctla4) inhibitor, a programmed cell death protein 1 (pd1) inhibitor, or a programmed death-ligand 1 (pdl-1) inhibitor, or combination thereof.. ... Incept Llc

10/18/18 / #20180297975

Cyclohexane derivative or stereoisomer or salt thereof, and preparation and use thereof

Provided are a cyclohexane derivative as shown by formula ib or a stereoisomer or a salt thereof, and the preparation and use thereof. The cyclohexane derivative has a high affinity for d3 receptors and 5-hydroxytryptamine, has a lower affinity for d2 receptors, shows a high selectivity for d3/d2 receptors, and can be used as a therapeutic drug against neuropsychiatric diseases; and the preparation method thereof is simple and easy.. ... Incept Llc

10/18/18 / #20180297974

Most effective process for base-free preparation of ketone intermediates usable for manufacture of nebivolol

Comprising the steps of: activation of a carboxylic acid by using a peptide coupling agent, coupling of the activated carboxylic acid with a malonic acid derivative providing a β-ketoester precursor and converting the β-ketoester precursor to the ketone of the general formula 1.. . ... Incept Llc

10/18/18 / #20180297966

Compounds, compositions, and methods of making and using the same

Compounds are provided according to formula (i), and hydrates thereof, and compositions thereof; and methods of using and making the same. Compounds of the present invention are contemplated useful for suppressing pain during cosmetic, medical, and dental procedures. ... Incept Llc

10/18/18 / #20180297962

Heterocyclic compounds useful in the treatment of disease

Heterocyclic compounds are described that are lysophosphatidic acid receptor ligands that are useful in the treatment of lysophosphatidic acid receptor-dependent diseases and conditions, including but not limited to diseases involving fibrosis, such as fibrosis of the heart, kidney, liver and lung, and scleroderma; inflammatory diseases such as diabetic nephropathy and nonalcoholic steatohepatitis (nash); ocular diseases such as diseases involving retinal degeneration; nerve diseases such as pruritus and pain.. . ... Incept Llc

10/18/18 / #20180297961

Tetrazole derivatives

Or to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof for use in the treatment of schizophrenia, bipolar disorder, obsessive-compulsive disorder or autism spectrum disorder.. . ... Incept Llc

10/18/18 / #20180297959

Benzimidazole derivatives, preparation method therefor, and applications thereof

The present invention belongs to the pharmaceutical field, and relates to a preparation method for a series of benzimidazole derivatives, their pharmaceutical salts and pharmaceutically acceptable prodrugs, a pharmaceutical composition containing the derivatives, and the uses of the derivatives and pharmaceutical composition in the preparation of antigout drugs and in the treatment of related diseases.. . ... Incept Llc

10/18/18 / #20180297958

Etomidate derivative and intermediate, preparation method and use thereof

The present invention discloses an etomidate derivative of formula 1, or a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, a pharmaceutical composition and a kit comprising the same, as well as intermediates and methods for preparing the same, and use thereof. The etomidate derivative of the present invention not only has good anesthetic activity, rapid onset, and short duration of action, but also shows little inhibition to the secretion of corticosteroids in animals, and therefore has both favorable anesthetic effect and safety profiles.. ... Incept Llc

10/18/18 / #20180297948

Sodium channel blockers

The present invention relates to a compound having a blocking effect against sodium ion channels, particularly nav1.7, a preparation method thereof and use thereof. The compound represented by the formula 1 or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof can be effectively used in the prevention or treatment of pains, for example, acute pain, chronic pain, pain from nervous disease, postoperative pain, migraine, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neuropathic disease, epilepsy, arrhythmia, myotonia, ataxia, multiple sclerosis, irritable bowel syndrome, urinary incontinence, visceral pain, depression, erythromelalgia, paroxysmal extreme pain disorder (pepd).. ... Incept Llc

10/18/18 / #20180297946

Polymorphic form of pyrrole derivative and intermediate thereof

The present invention relates to saroglitazar free acid of formula (ia) or its pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutically acceptable esters, stereoisomers, tautomers, analogs and derivatives thereof. The present invention also provides an amorphous form of saroglitazar free acid and processes of preparation thereof. ... Incept Llc

10/18/18 / #20180297945

Polymorphic form of pyrrole derivative and intermediate thereof

The present invention relates to saroglitazar free acid of formula (ia) or its pharmaceutically acceptable salts, pharmaceutically acceptable solvates, pharmaceutically acceptable esters, stereoisomers, tautomers, analogs and derivatives thereof. The present invention also provides an amorphous form of saroglitazar free acid and processes of preparation thereof. ... Incept Llc

10/18/18 / #20180297944

Substituted pyrrolidines as g-protein coupled receptor 43 agonists

The present invention is directed to novel compounds of formula (i) and their use in treating and/or preventing metabolic diseases.. . ... Incept Llc








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