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Incyte Holdings Corporation patents


Recent patent applications related to Incyte Holdings Corporation. Incyte Holdings Corporation is listed as an Agent/Assignee. Note: Incyte Holdings Corporation may have other listings under different names/spellings. We're not affiliated with Incyte Holdings Corporation, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "I" | Incyte Holdings Corporation-related inventors


Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors

The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the pim kinases and are useful in the treatment of diseases related to the activity of pim kinases including, e.g., cancer and other diseases.. ... Incyte Holdings Corporation

1,2,5-oxadiazoles as inhibitors of indoleamine 2,3- dioxygenase

The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.. . ... Incyte Holdings Corporation

Tricyclic fused thiophene derivatives as jak inhibitors

. . The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of janus kinase (jak) and are useful in the treatment of diseases related to the activity of jak including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.. . ... Incyte Holdings Corporation

Modulators of indoleamine 2,3-dioxygenase and methods of using the same

The present invention is directed to modulators of indoleamine 2,3-dioxygenase (ido), as well as compositions and pharmaceutical methods thereof.. . ... Incyte Holdings Corporation

Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2,3-b]pyrimidin-5-yl-amines as janus kinase inhibitors

The present invention provides pyrrolo[2,3-b]pyridine-4-yl amines pyrrolo[2,3-b]pyrimidin-4-yl amines that modulate the activity of janus kinases and are useful in the treatment of diseases related to activity of janus kinases including, for example, immune-related diseases and cancer.. . ... Incyte Holdings Corporation

1,2,5-oxadiazoles as inhibitors of indoleamine 2,3- dioxygenase

The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.. . ... Incyte Holdings Corporation

Amido compounds and their use as pharmaceuticals

. . The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (mr), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.. ... Incyte Holdings Corporation

Metabolites of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile

The present invention provides active metablites of 3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile that modulate the activity of janus kinases and are useful in the treatment of diseases related to activity of janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.. . ... Incyte Holdings Corporation

Salts of 2-fluoro-n-methyl-4-[7-(quinolin-6-yl-methyl)- imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same

The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-met kinase inhibitor 2-fluoro-n-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and pharmaceutical compositions thereof, useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. The present invention further relates to processes and intermediates for preparing 2-fluoro-n-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and salts thereof.. ... Incyte Holdings Corporation

Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors

The present invention provides azetidinyl phenyl, pyridyl, or pyrazinyl carboxamide derivatives, as well as their compositions and methods of use, that modulate the activity of janus kinase (jaks) and are useful in the treatment of diseases related to the activity of jak including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.. . ... Incyte Holdings Corporation

Piperidin-4-yl azetidine derivatives as jak1 inhibitors

The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of janus kinase 1 (jak1) and are useful in the treatment of diseases related to the activity of jak1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.. . ... Incyte Holdings Corporation

Tricyclic heterocycles as bet protein inhibitors

The present invention relates to tricyclic heterocycles which are inhibitors of bet proteins such as brd2, brd3, brd4, and brd-t and are useful in the treatment of diseases such as cancer.. . ... Incyte Holdings Corporation

Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors

The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the pim kinases and are useful in the treatment of diseases related to the activity of pim kinases including, e.g., cancer and other diseases.. ... Incyte Holdings Corporation

Bicyclic heterocycles as fgfr inhibitors

The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of one or more fgfr enzymes and are useful in the treatment of fgfr-associated diseases such as cancer.. . ... Incyte Holdings Corporation

06/15/17 / #20170165263

Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3

The present invention relates to substituted imidazopyridazines and substituted benzimidazoles, as well as pharmaceutical compositions comprising the same, which are fgfr3 inhibitors useful in the treatment of cancer and other diseases.. . ... Incyte Holdings Corporation

06/08/17 / #20170158696

N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors

The present invention provides n-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines derivatives that modulate the activity of phosphoinositide 3-kinases (pi3ks) and are useful in the treatment of diseases related to the activity of pi3ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.. . ... Incyte Holdings Corporation

05/18/17 / #20170137424

Substituted tricyclic compounds as fgfr inhibitors

The present invention relates to tricyclic compounds, and pharmaceutical compositions of the same, that are inhibitors of one or more fgfr enzymes and are useful in the treatment of fgfr-associated diseases such as cancer.. . ... Incyte Holdings Corporation

03/30/17 / #20170087158

Janus kinase inhibitors for treatment of dry eye and other eye related diseases

The present application relates to janus kinase (jak) inhibitors, including 3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile, for the treatment of a dry eye disorder or ameliorating a particular symptom of a dry eye disorder, such as eye discomfort, visual disturbance, tear film instability, tear hyperosmolarity, and inflammation of the ocular surface, as well as kits and compositions, including topical compositions, related thereto.. . ... Incyte Holdings Corporation

03/16/17 / #20170071947

Heteroaryl substituted pyrrolo[2,3-b] pyridines and pyrrolo[2,3-b] pyrimidines as janus kinase inhibitors

The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of janus kinases and are useful in the treatment of diseases related to activity of janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.. . ... Incyte Holdings Corporation

02/23/17 / #20170050987

Pyrimidinones as pi3k inhibitors

The present invention provides pyrimidinones that modulate the activity of phosphoinositide 3-kinases (pi3ks) and are useful in the treatment of diseases related to the activity of pi3ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.. . ... Incyte Holdings Corporation

01/19/17 / #20170015674

Processes and intermediates for making a jak inhibitor

. . This invention relates to processes and intermediates for making {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]azetidin-3-yl}acetonitrile, useful in the treatment of diseases related to the activity of janus kinases (jak) including inflammatory disorders, autoimmune disorders, cancer, and other diseases.. . ... Incyte Holdings Corporation








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