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Indiana University Research And Technology Corp patents


Recent patent applications related to Indiana University Research And Technology Corp. Indiana University Research And Technology Corp is listed as an Agent/Assignee. Note: Indiana University Research And Technology Corp may have other listings under different names/spellings. We're not affiliated with Indiana University Research And Technology Corp, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "I" | Indiana University Research And Technology Corp-related inventors


Insulin-incretin conjugates

Disclosed herein are insulin agonist peptides conjugated to a glucagon analog wherein the insulin/glucagon conjugate is targeted to liver tissues upon administration to a patient.. . ... Indiana University Research And Technology Corp

Protein tyrosine phosphatases or shp2 inhibitors and uses thereof

Small molecule compounds derived from α-sulfophenylacetic amide (spaa) are provided as novel sulfonic acid based ptyr mimetics. These compounds effectively inhibit a variety of protein tyrosine phosphatases (ptps), such as mptpa, mptpb, lmwptp, and laforin. ... Indiana University Research And Technology Corp

Small molecule inhibitors of protein tyrosine phosphatases and used thereof

Small molecule compounds derived from α-sulfophenylacetic amide (spaa) are provided as novel sulfonic acid based ptyr mimetics. These compounds effectively inhibit a variety of protein tyrosine phosphatases (ptps), such as mptpa, mptpb, lmwptp, and laforin. ... Indiana University Research And Technology Corp

Method and apparatus for 3d facial recognition

The present disclosure relates to methods and apparatuses for 3-d facial recognition using the fast multipole method (fmm).. . ... Indiana University Research And Technology Corp

Double knockout (gt/cmah-ko) pigs, organs and tissues

The invention provides double knockout transgenic pigs (gt/cmah-ko pigs) lacking expression of any functional αgal and cmah. Double knockout gt/cmah-ko transgenic organs, tissues and cells are also provided. ... Indiana University Research And Technology Corp

Inhibition of lncrna hotair and related materials and methods

Embodiments disclosed herein concern compositions and methods for treating a condition characterized by overexpression of long non-coding rna hotair. In certain embodiments, synthetic polynucleotide analogs capable of hybridizing with a target sequence domain of hotair are provided. ... Indiana University Research And Technology Corp

Materials and methods for treating bacterial infections using c-1 gentamicin

Various aspects relate to the use of c-1 gentamicin as an antibiotic effective for the treatment of a bacterial infection, a genetic disorder, or cancer in a subject.. . ... Indiana University Research And Technology Corp

Cell culture systems for producing il-33 induced t9 cells and methods of using the cells

Cell culture systems for producing il-33 induced t9 cells and methods of using the il-33 induced t9 cells (t9il-33 cells) in a cell therapy for increasing anti-tumoral activity following allogeneic hematopoietic cell transplantation (hct) and/or treating graft-versus-host disease (gvhd) are disclosed herein. Further, methods of using the t9il-33 cells, alone or in combination with allogeneic hematopoietic cell transplantation, are described herein for cancer treatment.. ... Indiana University Research And Technology Corp

Peptides that modulate the effect of the crmp: neurofibromin complex on synaptic transmission

The present disclosure relates generally to materials and methods for studying and treating neurofibromatosis type 1 (nf1) by modulating the interaction of crmp-2 and neurofibromin. Some embodiments relates to newly synthesized polypeptides or a pharmaceutically acceptable salt thereof. ... Indiana University Research And Technology Corp

Rechargeable alkaline metal and alkaline earth electrodes having controlled dendritic growth and methods for making and using same

A device for extending the life of a battery, including an electrode having a metal portion, wherein the metal portion is selected from the group including lithium, calcium, magnesium, sodium, potassium and combinations thereof, an electrolyte permeable membrane, and a metal dendrite seeding material disposed between the electrode and the membrane. The electrode, the membrane and the metal dendrite seeding material are positioned in an electrolyte matrix. ... Indiana University Research And Technology Corp

Flow assembly for cells

In one embodiment, a flow assembly for cells comprises a first flow path configured to receive a plurality of cells, a second flow path configured to receive a buffer, and a third flow path configured to receive the plurality of cells and the buffer. The plurality of cells are in a single-file orientation and the buffer generally surrounds the single-file orientation of the plurality of cells when in the third flow path.. ... Indiana University Research And Technology Corp

Targeting cgmp-related phosphodiesterases to reduce cyst formation in cystic kidney disease, and related materials and methods

Described herein is the identification of cgmp-specific phosphodiesterase upregulation in cystic kidney diseases. Also described is the use of cgmp-specific phosphodiesterase inhibitors for preventing the progression and/or treatment of cystic kidney diseases. ... Indiana University Research And Technology Corp

Compositions and systems for conferring disease resistance in plants and methods of use thereof

Compositions, systems and methods are provided for conferring disease resistance to plant pathogens that use proteases to target plant substrate proteins inside plant cells. Briefly, the compositions, systems and methods are based upon plant substrate proteins that are targeted by pathogen-specific proteases and that activate nucleotide binding site-leucine rich repeat (nb-lrr) disease resistance proteins when cleaved by the protease. ... Indiana University Research And Technology Corp

High torque density electric motor and/or generator

An electric motor is disclosed, comprising a stator and a rotor mounted relative to the stator to form a gap between a surface of the stator and a surface of the rotor, the gap having a width. One of the stator and the rotor is mounted for movement relative to the other of the stator and the rotor about a central axis, and one of the stator and the rotor is mounted for movement relative to the other of the stator and the rotor along the central axis in response to thermal expansion of at least one of the stator and the rotor to maintain the width of the gap.. ... Indiana University Research And Technology Corp

02/01/18 / #20180033600

Device and method for analysis of biofluids by ion generation using wetted porous material

The present disclosure provides a mass spectrometry cartridge and methods of use thereof.. . ... Indiana University Research And Technology Corp

02/01/18 / #20180030442

Microrna therapy for pancreatic cancer

Methods for inhibiting pancreatic cancer cell migration and invasion are disclosed herein. Further, methods for inhibiting autophagy are disclosed. ... Indiana University Research And Technology Corp

01/18/18 / #20180017561

Th17-prone cd146+ccr5+ t-cell population as an early marker of intestinal graft-versus-host disease

Th17-prone cd146+ccr5+ t-cell population as an early biomarker of intestinal graft-versus-host disease and its use for determining prognosis of intestinal gvhd before the clinical signs are apparent are disclosed.. . ... Indiana University Research And Technology Corp

01/04/18 / #20180003725

Methods and systems for predicting bleeding risk and dose of plasminogen activator

The present disclosure provides a method and system for estimating the clinical responsiveness of a patient to a dose of a plasminogen activating agent to treat a thrombosis, comprising determining a concentration of α2-antiplasmin in a blood sample of the patient, determining a concentration of activated fibrinolysis inhibitor (“tafi”) in the blood sample, determining a concentration of plasminogen activator inhibitor 1 (“pai-1”) in the blood sample, computing a clot lysis time (“clt”) based on the concentrations of a2-antiplasmin, tafi and pai-1 using the equation clt=−2,813.6+31.1*a2-antiplasmin (percent activity)+31.1*tafi (percent activity)+1.49 pai-1 (ug/l), and determining that the patient is at increased risk of hemorrhage when the computed clt is less than a first predetermined cutoff time.. . ... Indiana University Research And Technology Corp

01/04/18 / #20180002728

Culture conditions that allow zymomonas mobilis to assimilate n2 gas as a nitrogen source during bio-ethanol production

Chemically defined culture medium and culture conditions that allow bacteria to assimilate dinitrogen gas (n2) as a nitrogen source during bio-ethanol production are disclosed herein. Methods of bioethanol production using the chemically defined culture medium and culture conditions are also disclosed.. ... Indiana University Research And Technology Corp

12/07/17 / #20170349642

Glucagon/glp-1 receptor co-agonists

Provided herein are peptides and variant peptides that exhibit enhanced activity at the glp-1 receptor, as compared to native glucagon.. . ... Indiana University Research And Technology Corp

11/23/17 / #20170338567

Multiband wavelength selective structure

A wavelength selective structure for selectively reflecting or absorbing incident electromagnetic visible or infrared radiation. The wavelength selective structure includes a wavelength selective structure with a plurality of layers, including a compound layer forming a plurality of surface elements, an electrically isolating intermediate layer, wherein the compound layer is in contact with a first surface of the electrically isolating intermediate layer, and a continuous electrically conductive layer in contact with a second surface of the electrically isolating intermediate layer. ... Indiana University Research And Technology Corp

11/16/17 / #20170328910

Pro-angiogenic and anti-angiogenic hematopoietic progenitor cell populations

Methods for identifying active angiogenesis and vasculopathy are described. More particularly, the present disclosure relates to cellular biomarkers, and to methods of screening cellular biomarkers for identifying active angiogenesis.. ... Indiana University Research And Technology Corp

11/09/17 / #20170321220

Presentation of bioactive proteins

The invention provides a fusion protein comprising an antigen binding domain linked to a bacteriophage decoration (dec) protein along with a polynucleotide comprising the nucleic acid sequence of the fusion protein and a vector comprising the polynucleotide. Additionally, the invention provides a composition comprising the fusion protein and a virus-like particle (vlp), and a method of treating a disease in a mammal comprising administering a therapeutically effective amount of the composition to the mammal. ... Indiana University Research And Technology Corp

10/26/17 / #20170307636

Biomarker for determining mitochondrial damage in friedreich's ataxia

Compositions and methods for screening for a disease or a disorder associated with a deficiency in frataxin in a subject using biomarkers for diseases or disorders associated with a deficiency in frataxin are disclosed. The compositions and methods include determining the acetylation status of mito-chondrial proteins. ... Indiana University Research And Technology Corp

10/26/17 / #20170307565

Hybrid ion mobility spectrometer

A hybrid ion mobility spectrometer includes a single-pass drift tube having an ion inlet and an ion outlet, a multiple-pass drift tube having an ion inlet and an ion outlet each coupled to the single pass drift tube between the ion inlet and the ion outlet thereof, and at least one ion steering channel controllable to selectively pass ions traveling through the single-pass drift tube into the multiple-pass drift tube via the ion inlet of the multiple-pass drift tube and to selectively pass ions traveling through the multiple-pass drift tube into the single-pass drift tube via the ion outlet of the multiple-pass drift tube. The single-pass drift tube separates in time ions traveling therethrough according to a first function of ion mobility, and the multiple-pass drift tube separates in time ions traveling one or more times therethrough according to the first or a second function of ion mobility.. ... Indiana University Research And Technology Corp

10/26/17 / #20170304462

Artificial antigen-presenting cells and methods for producing and using the same

Described herein are biomimetic janus particles useful as artificial antigen presenting cells capable of activating t cells in vitro. “bull's eye” ligand patterns mimicking either the native or reverse organization of the t cell immunological synapse are provided on the surface of nano- or micro-sized particles. ... Indiana University Research And Technology Corp

10/05/17 / #20170283479

Lipidated amide-based insulin prodrugs

Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half-lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.. ... Indiana University Research And Technology Corp

10/05/17 / #20170281788

Incretin-insulin conjugates

Disclosed herein are insulin agonist peptides conjugated to incretins wherein the incretin-insulin conjugate has agonist activity at the insulin receptor and the corresponding incretin receptor, and stimulates weight loss in an individual administered the compound.. . ... Indiana University Research And Technology Corp

09/28/17 / #20170273609

Method and apparatus for assessing tissue oxygenation saturation

A method and apparatus for assessing tissue oxygenation saturation during physical activity comprising the steps of providing at least one near-infrared spectroscopy probe including at least one near-infrared light source and at least one photodetector-and measuring oxygen saturation in at least one of a skin dermis layer, an adipose layer and a muscular fascial layer of a user.. . ... Indiana University Research And Technology Corp

09/21/17 / #20170266253

Antithetical regulation of endothelial ace and ace2 by brg1-foxm1 complex underlies pathological cardiac hypertrophy

. . Methods are disclosed herein for administering a foxm1 inhibitor for preventing, treating, and/or reducing cardiac hypertrophy and/or cardiac failure. Particularly, the methods are directed to the use of a foxm1 inhibitor to block the function of foxm1-brg1 complex, thereby reversing the ace/ace2 expression ratio such to protect the heart from hypertrophy and failure.. ... Indiana University Research And Technology Corp

09/14/17 / #20170261518

Biomarkers and assay to detect chronic graft versus host disease

A four-biomarker panel for diagnosis of chronic graft-versus-host disease (cgvhd) and methods of prognosing and/or diagnosing cgvhd using the biomarker panel are disclosed.. . ... Indiana University Research And Technology Corp

09/07/17 / #20170251646

Transgenic pigs lacking one or more cellular transport genes

The application provides methods of improving a medication related side effect in a human after transplant of transgenic organs, tissues or cells from transgenic pigs with a disrupted cellular transport gene or genes, and porcine organs, tissues, and cells therefrom are provided.. . ... Indiana University Research And Technology Corp

09/07/17 / #20170251629

Method and apparatus for spatial cognitive assessment of a lab animal

The present disclosure relates to a method and apparatus for performing a cognitive bias assay on a lab animal. The apparatus may include a first base member and a second base member spaced apart from the first base member to form an interior region between the first and second base members. ... Indiana University Research And Technology Corp

08/31/17 / #20170248612

Methods for detecting sinusoidal obstructive syndrome (sos)

Disclosed are biomarker panels for evaluating subjects at risk of sinusoidal obstruction syndrome (sos) early after hematopoietic stem cell transplantation (hsct). In particular, the present disclosure relates to the use of one or more of st2, ang2, l-ficolin, ha, and vcam1 for prognosing, diagnosing, and/or treating sos.. ... Indiana University Research And Technology Corp

08/17/17 / #20170231548

System and method for bladder transducer placement

A tissue sensing device and a method for placing the device. The device including a first electrically conductive needle; a non-conductive sheath receiving the first needle therein and allowing exposure of a portion the first needle at a distal end thereof; a second electrically conductive needle; and electronics coupled to the first and second needle, the electronics providing for sensing of capacitance between the first and second needles so as to provide an indication of a tissue in which the exposed portion of the first needle is located.. ... Indiana University Research And Technology Corp

08/10/17 / #20170227147

Conduit identification tags

An identifier for a conduit includes a first tag having a body with a first aperture formed therein for receiving the conduit and a first identifying feature, and a second tag having a body with a second aperture formed therein for receiving the conduit and a second identifying feature that matches the first identifying feature. The first tag is attached to the conduit adjacent one end, the second tag is attached to the conduit adjacent another end, and the ends are identified as ends of the same conduit by the matching first and second identifying features.. ... Indiana University Research And Technology Corp

08/03/17 / #20170220743

Tracking real-time assessment of quality monitoring in endoscopy

The present disclosure provides a method for making clinical recommendations, comprising receiving pathology reports by a computing device; processing the pathology reports by the computing device using natural language processing software, including a custom pathology dictionary; generating, using the computing device, a document based on the processing of the pathology reports; and using the document to output a clinical recommendation.. . ... Indiana University Research And Technology Corp

07/27/17 / #20170211039

Method for producing retinal ganglion cells from pluripotent cells

A method of making retinal ganglion cells, comprises the steps of: (a) differentiating pluripotent stem cells into retinal progenitor cells; and, (b) differentiating retinal progenitor cells into retinal ganglion cells.. . ... Indiana University Research And Technology Corp

07/06/17 / #20170191963

Ion mobility spectrometer and method of operating same

An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field sources may each be coupled to one or more of the plurality of drift tube segments. ... Indiana University Research And Technology Corp

07/06/17 / #20170189362

Tuneable delivery of nanoparticle bound active plasmin for the treatment of thrombosis

Compositions and methods for therapeutic delivery are disclosed. More particularly, the present disclosure relates to nanoparticle compositions that sequester the activity of a target molecule while leaving other domains accessible to bind targeted tissues of interest. ... Indiana University Research And Technology Corp

06/29/17 / #20170182055

Materials and method for inhibiting replication protein a and uses thereof

Targeting uncontrolled cell proliferation and resistance to dna damaging chemotherapeutics with at least one reagent has significant potential in cancer treatment. Replication protein a, the eukaryotic single-strand (ss) dna binding protein, is essential for genomic maintenance and stability via roles in both dna replication and repair. ... Indiana University Research And Technology Corp

06/15/17 / #20170170487

Systems and methods of graphene supported catalysts

Functionalized graphene comprising graphene, a metal dispersed throughout the graphene, wherein the metal comprises pt, rh, pd, ag, au, ni, os, ir, alloys thereof, oxides thereof, or mixtures thereof, and a first functional group covalently bonded to the graphene, wherein the first functional group comprises sulfonate, so3−, carboxylate, coo−, a tertiary amine, nr3+, where r is h, alkyl, aryl, or combinations thereof, polybenzimidazole (pbi), poly(ethylene oxide) (peo), polyphenylene oxide (ppo), polyaniline, or mixtures thereof are disclosed. Methods of manufacture are also disclosed.. ... Indiana University Research And Technology Corp

06/08/17 / #20170157426

System and method for reducing biological damage in proton therapy

Systems comprising a processor in electrical communication with a tangible, non-transitory memory that, in response to an execution by the processor, cause the processor to measure a relative biological effectiveness of a beam on a region of a human body, and a beam applicator in electrical communication with the processor, wherein a characteristic of the beam can be adjusted based on the measured relative biological effectiveness are disclosed. Methods of treatment comprising measuring, by a processor capable of detecting potential biological hot spots, a relative biological effectiveness of a beam on a region of a human body, designing a beam therapy treatment plan based on the measured relative biological effectiveness, and applying a beam to a patient with a region in need of beam therapy with a beam applicator in electrical communication with the processor capable of detecting potential biological hot spots are also disclosed.. ... Indiana University Research And Technology Corp

06/01/17 / #20170155129

High-energy rechargeable lithium-sulfur batteries

Methods of manufacturing comprising placing a mixture comprising sulfur powder, a carbon nanotube, an alcohol soluble binder, and a solvent into a cast and removing a solvent from the mixture to form an electrode are disclosed. Electrodes and batteries comprising sulfur, a carbon nanotube, and an alcohol soluble binder are also disclosed.. ... Indiana University Research And Technology Corp

05/04/17 / #20170123092

Systems and methods for detection of well properties

Methods comprising electronically receiving information of a reflection of a known first sound pulse, electronically receiving information of a reflection of a known second sound pulse, determining, by a processor, a change in a first property between a known first sound pulse and a reflection of the known first sound pulse, determining, by the processor, a change in a second property between a known second sound pulse and a reflection of the known second sound pulse, comparing, by the processor, the change in the first property of the first known sound pulse with the change in the second property of the second known sound pulse, and determining, by the processor, a condition of a well in response to the comparison of the change of the first property with the change of the second property are disclosed. Systems for determining a condition of a well are also disclosed.. ... Indiana University Research And Technology Corp

04/20/17 / #20170108512

Use of biomarkers for detection of excessive alcohol use

Methods of diagnosing excessive alcohol use are disclosed herein. More particularly, the present disclosure is directed to methods of diagnosing excessive alcohol use by identifying expression levels of various serum biomarkers. ... Indiana University Research And Technology Corp

04/20/17 / #20170105710

System and method for extracting tissue samples

A method and apparatus for extracting tissue samples are disclosed herein. An example apparatus disclosed herein includes a first sidewall and a second sidewall spaced apart from the first sidewall. ... Indiana University Research And Technology Corp

03/16/17 / #20170078559

Three dimensional moving pictures with a single imager and microfluidic lens

A method and system for determining depth of an image using a single imager and a lens having a variable focal length is provided. The system comprises a microfluidic lens having a variable focal length controlled by a lens controller and an imager receiving an image of an object from the lens, wherein the imager is configured to receive a first image comprising a first plurality of pixels from the lens at a first focal length and a second image comprising a second plurality of pixels from the lens at a second focal length, the second focal length being different than the first focal length, non-volatile memory, wherein the first image and the second image are stored in the non-volatile memory, a depth module configured to determine a distance between the lens and the object based by a comparison of the first image of the object and the second image of the object.. ... Indiana University Research And Technology Corp

03/09/17 / #20170067053

Methods for preventing and treating chronic kidney disease (ckd)

The present invention relates to methods for preventing and treating chronic kidney disease (ckd).. . ... Indiana University Research And Technology Corp

02/16/17 / #20170044485

Materials and methods for identifying and using yeast strains that metabolize pentose sugars in the presence of d-glucose

Disclosed herein are materials and methods for creating and/or isolating variants of yeasts especially variants of saccharomyces cerevisiae that can grow on sugars other than d-glucose in the presence of amounts of 2-deoxy-glucose and or d-glucose that inhibit most strains of yeast from growing on sugars other than d-glucose. Selection media that can be used to isolate such variants include pentose sugars such as d-xylose, l-glutamine and 2-deoxy-glucose. ... Indiana University Research And Technology Corp

02/16/17 / #20170044097

Antibacterials and/or modulators of biofilm formation and methods of using the same

Amides substituted with aromatic groups were synthesized and some were purified to create enantiomer pure compounds. The compounds were tested to determine their ability to inhibit the growth of bacteria and the formation of biofilms created by bacteria. ... Indiana University Research And Technology Corp

02/09/17 / #20170035782

Modulation of inflammation using progesterone metabolites

Methods for modulating inflammation using progesterone metabolites are disclosed. More particularly, methods of administering progesterone metabolites, 6β-hydroxyprogesterone (6β-ohp) and 16α-hydroxyprogesterone (16α-ohp) are disclosed for mitigating inflammation in various tissue types in the body.. ... Indiana University Research And Technology Corp

02/02/17 / #20170030916

Materials and methods for diagnosing and predicting the course of prostate cancer

Expression of forkhead-box protein a1 (foxa1), a transcription factor important for the normal development of the prostate gland is thought to be controlled by steroid hormones and gata-3. Expression of foxa1, gata-3 and androgen receptor (ar) was retrospectively analyzed by immunohistochemistry (ihc) in a series of 80 primary tumors and 28 metastatic prostate cancers including 15 matched paired samples. ... Indiana University Research And Technology Corp

02/02/17 / #20170029907

Generalizable assay for virus capsid assembly

Virus capsids protect the viral genome and play roles in its delivery and intracellular transport, making them an attractive target for antiviral therapeutics. The difficulty in targetting capsid assembly is to identify molecules that interfere with the weak protein-protein interactions that drive the reaction. ... Indiana University Research And Technology Corp

01/26/17 / #20170022476

Method for generating endothelial colony forming cell-like cells

The present disclosure relates generally to methods and compositions useful in cell and tissue biology and therapeutics. In particular, an in vitro method for differentiating pluripotent cells into endothelial colony forming cell-like cells (ecfc-like cells) is provided. ... Indiana University Research And Technology Corp

01/05/17 / #20170005328

Novel carbonized polyaniline-grafted silicon nanoparticles encapsulated in graphene sheets for li-ion battery anodes

A method for producing a graphene-composite material, including removing any oxide layer from each of a plurality of silicon nanoparticles, forming a polyaniline layer over each clean silicon nanoparticle, binding a graphene oxide sheet to the polyaniline layer of each particle, and carbonizing the polyaniline to yield a plurality of composite particles. Each composite particle has a graphene outer layer substantially encapsulating a silicon inner core.. ... Indiana University Research And Technology Corp








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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