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Insilico Medicine Inc patents

Recent patent applications related to Insilico Medicine Inc. Insilico Medicine Inc is listed as an Agent/Assignee. Note: Insilico Medicine Inc may have other listings under different names/spellings. We're not affiliated with Insilico Medicine Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "I" | Insilico Medicine Inc-related inventors

Brd2 protein inhibitor compounds and uses thereof

The present invention provides bioinformatics methods for predicting efficient protein inhibitors, compounds synthesized based on the methods and uses thereof, the method including identifying a brd2 inhibitor by performing a pharmacophore-based search to produce a first plurality of candidate agents, applying a docking method to the first plurality of candidate agents to output a second plurality of candidate agents to provide at least one brd2 inhibitor which are 2-acetyl-n,n,3-trisubstituted-5-[(substituted sulfonyl)substituted]imidazole-4-carboxamide and 1-{1,3,4-trisubstituted-5-[(substituted sulfonyl)substituted]-1h-pyrrol-2-yl}ethan-1-one, configured to inhibit the brd2 protein.. . ... Insilico Medicine Inc

Withaferin compositions for prevention of aging

The present invention provides gero-protective pharmaceutical compositions and methods, the compositions being adapted to enhance at least one of cell survival and cell metabolism in a mammalian subject, the pharmaceutical compositions include at least two of withaferin a or its structural analogs, coumestrol, ginsenoside, quinidine, silymarin, licochalcone a, lipoic acid and apigenin, in a pharmaceutically effective amount.. . ... Insilico Medicine Inc

Systems, methods and software for ranking potential geroprotective drugs

The present invention provides improved systems, methods and software for determining a pathway activation strength in old subjects relative to young subjects of the same species, the method including collecting young subject transcriptome data and old subject transcriptome data for one species to evaluate pathway activation strength (pas) and down-regulation strength for a plurality of biological pathways, mapping the plurality of biological pathways for the activation strength and down-regulation strength from old subject samples relative to young subject samples to form a pathway cloud map and providing a gero-protective rating for each of a plurality of drugs in accordance with a drug rating for minimizing signaling pathway cloud disturbance (spcd) in the pathway cloud map of the one species to provide a ranking of the gero-protective drugs.. . ... Insilico Medicine Inc

System, method and software for robust transcriptomic data analysis

The present invention provides systems, methods and software for improving robustness of transcriptomic data analysis, the method including receiving control cell transcriptomic data (c) and cell transcriptomic data (s) under study for a gene, calculating a fold change ratio (fc) for the gene, repeating these steps for a plurality of genes, grouping co-expressed genes into modules, estimating gene importance factors based on a network topology, mapped from a plurality of the modules and obtaining a insilico pathway activation network decomposition analysis (ipanda) value, wherein the ipanda value has a pearson coefficient greater than a pearson coefficient associated with another platform for manipulating the same data.. . ... Insilico Medicine Inc

System, method, and software for improved drug efficacy and safety in a patient

The present invention provides systems, methods and software for predicting drug efficacy for treating a disorder in a patient, the method including providing a drug scoring database based on pathway activation strengths (pass) for a plurality of biological pathways associated with the drug in the treatment of the disorder, thereafter providing a support vector machines (svm) to enable svm tuning using a floating window to transfer data from a training dataset (t) to a validation dataset (v) by interpolation along at least one pas axis and further determining if both i) there is a positive correlation coefficient between a drug score and a clinical efficacy of the drug and ii) an area-under a curve (auc) statistical indicator for the drug score exceeds 0.7; to provide a predictive indication if the patient is a responder or non-responder to the drug to determine whether the drug should be used in treating the patient.. . ... Insilico Medicine Inc

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009


This listing is an abstract for educational and research purposes is only meant as a recent sample of applications filed, not a comprehensive history. is not affiliated or associated with Insilico Medicine Inc in any way and there may be associated servicemarks. This data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Insilico Medicine Inc with additional patents listed. Browse our Agent directory for other possible listings. Page by