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Institut National De La Sante Et De La Recherche Medicale patents


Recent patent applications related to Institut National De La Sante Et De La Recherche Medicale. Institut National De La Sante Et De La Recherche Medicale is listed as an Agent/Assignee. Note: Institut National De La Sante Et De La Recherche Medicale may have other listings under different names/spellings. We're not affiliated with Institut National De La Sante Et De La Recherche Medicale, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "I" | Institut National De La Sante Et De La Recherche Medicale-related inventors


1,4-di-(4-methylthiophenyl)-3-phtaloylazetidine-2-one and the derivatives thereof

The present invention relates to a compound with formula (i) or a salt and/or a pharmaceutically acceptable solvate thereof, the method for preparing same as well as the uses thereof, in particular the therapeutic use thereof, mainly in the treatment of diseases associated with a hyperactivity of the endocannabinoid system.. . ... Institut National De La Sante Et De La Recherche Medicale

Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy

The success of anti-tumor immune responses requires effector t cells to infiltrate solid tumors, a process guided by chemokines. Herein, we demonstrate that in vivo post-translational processing of chemokines by dipeptidylpeptidase 4 (dpp4, also known as cd26) limits lymphocyte migration to sites of inflammation and tumors. ... Institut National De La Sante Et De La Recherche Medicale

Cd34+cd41dim megakaryocytes progenitors and uses thereof for producing proplatelet-bearing mks and/or platelets

The invention relates to a method of producing cd34+cd4dim megakaryocyte (mk) progenitor cells, and substantially pure cell population of megakaryocyte precursor cells obtained by said method. The invention also relates to a method of producing proplatelet-bearing mks and/or platelets using the cd34+cd4dim cells.. ... Institut National De La Sante Et De La Recherche Medicale

Vaccine composition against chlamydiaceae infections

The invention relates to vaccine compositions for treating and/or preventing infections by a bacterium of the chlamydiaceae family, said compositions comprising bacteria of the chlamydiaceae family, which have been previously treated by at least one peptidoglycan inhibitor, or extracts of said treated bacteria.. . ... Institut National De La Sante Et De La Recherche Medicale

Method for generating t-cell progenitors

The invention relates to the field of cell therapy and to an in vitro method for generating t-cell progenitors, comprising the step of exposing cd34+ cells in a medium containing a notch ligand, a soluble domain of the delta-like ligand 4, joined to an fc region of a protein igg, in the presence of a fragment of fibronectin comprising the motifs rgds and cs-1 and a heparin-binding domain.. . ... Institut National De La Sante Et De La Recherche Medicale

Pathology prognosis method

The invention relates to a method for the prognosis a person's susceptibility to environmental stress. The method includes: a step of determining the sequence for initiating the translation of at least one of the genes from the ccnd family, and a step of quantifying the expression of the protein encoded by said gene, the translation initiation sequence of which was sequenced in the previous step, and comparing said expression with the expression level of said protein from a reference sample.. ... Institut National De La Sante Et De La Recherche Medicale

Method for the diagnosis of disorders caused by fetal alcohol syndrome

The present invention provides a method for the diagnosis of disorders caused by foetal alcohol syndrome, said method comprising the assaying of plgf (placental growth factor).. . ... Institut National De La Sante Et De La Recherche Medicale

Nanoparticle-based antigen specific immunotherapy

The present invention provides a nano particle comprising: a core comprising metal atoms; a corona comprising a plurality of ligands covalently linked to the core, wherein said plurality of ligands comprises: at least one carbohydrate ligand; at least one glutathione ligand; and at least one autoantigen peptide ligand. Also provided are compositions and vaccines comprising the nanoparticles, methods for producing the nanoparticles and medical uses of the nanoparticles, including for antigen specific imunotherapy of an autoimmune disease, such as diabetes mellitus type 1, in a mammalian subject.. ... Institut National De La Sante Et De La Recherche Medicale

Dynamin 2 inhibitor for the treatment of duchenne's muscular dystrophy

The present disclosure relates to an inhibitor of dynamin 2 or composition comprising the same for use in the treatment of duchenne's muscular dystrophy.. . ... Institut National De La Sante Et De La Recherche Medicale

Nucleoside-lipid compounds with ph-sensitive dialkylorthoester chains and their use for transportation or vectorization of at least one therapeutic agent

The invention relates to new nucleoside-lipid compounds with ph-sensitive dialkylorthoester chains, to the process for their preparation and to their uses, in particular their use for transportation or vectorization of at least one therapeutic agent.. . ... Institut National De La Sante Et De La Recherche Medicale

Simulation system, corresponding devices, methods and programs

A module for simulating an operative procedure within a virtual environment. The virtual environment is implemented by using a device for processing virtual environment data. ... Institut National De La Sante Et De La Recherche Medicale

Laser printing method and device for implementing said method

A method for printing uses at least one ink. The method includes: a step of focusing a laser beam so as to generate a cavity in an ink film; a step of forming at least one ink droplet from a free surface of the ink film; and a step of depositing the droplet onto a depositing surface of a receiving substrate positioned at a given distance from the film. ... Institut National De La Sante Et De La Recherche Medicale

Anti il-34 antibodies

The present disclosure relates to novel anti il-34 antibodies or antigen-binding fragments thereof specifically binding cytokine il-34 with high affinity, the method of obtaining of these antibodies and their therapeutic use.. . ... Institut National De La Sante Et De La Recherche Medicale

Use of hepcidin as a regulator of iron homeostasis

The invention concerns the use of hepcidin for the diagnosis and therapy of disorders of iron homeostasis. Hepcidin can be used in the treatment of disorders resulting from iron overload while inhibitors of hepcidin can be used in the treatment of anaemia.. ... Institut National De La Sante Et De La Recherche Medicale

11/23/17 / #20170337473

Method for unsuper vised sorting in real time of action potentials of a plurality of biological neurons

A method for unsupervised sorting, in real time, of action potentials of biological neurons by a network of artificial neurons including input, intermediate and output layers, the method according to which: the input layer receives an electrical signal measuring an electrical activity of biological neurons, the electrical signal having a variable amplitude as a function of action potentials emitted by the plurality of biological neurons over time; the input layer converts the amplitude of the electrical signal into a train of first spikes; the input layer transmits the train of first spikes to the intermediate layer; the intermediate layer converts the train of first spikes into a train of second spikes; the intermediate layer transmits the train of second spikes to the output layer; as a function of the train of second spikes, the output layer sorts each occurrence of each type of action potential present in the electrical signal.. . ... Institut National De La Sante Et De La Recherche Medicale

11/23/17 / #20170335276

Method of culturing segmented filamentous bacteria in vitro

The present invention relates to an in vitro method of culturing a segmented filamentous bacterium strain, comprising co-culturing said segmented filamentous bacterium strain with a eukaryotic host cell, wherein the culture is performed at an o2 level inferior to 5% in a rich tissue culture liquid medium containing bacterial medium components including iron. The present invention also relates to methods for genetically modifying a segmented filamentous bacterium strain comprising a step a culturing the strain in vitro.. ... Institut National De La Sante Et De La Recherche Medicale

11/09/17 / #20170320263

Method for laser printing biological components, and device for implementing said method

A method for printing uses at least one bio-ink. The method also uses at least one laser print head to deposit at least one droplet of at least one bio-ink onto a depositing surface of a receiving substrate. ... Institut National De La Sante Et De La Recherche Medicale

10/26/17 / #20170304489

Time-controlled glucose releasing hydrogels and applications thereof

The present invention relates generally to a hydrogel releasing glucose in a time-controlled manner, to medical applications thereof, and to a method for preparing said hydrogel.. . ... Institut National De La Sante Et De La Recherche Medicale

10/05/17 / #20170283890

Mutant bordetella strains and methods of use

A method of reducing or preventing the development of airway inflammation in a subject includes the step of infecting the respiratory tract of a subject an amount of a composition including a pharmaceutically acceptable carrier and live attenuated pertactin-deficient bordetella bacteria sufficient to colonize the respiratory tract of the subject. The step of infecting the subject with the live attenuated pertactin-deficient bordetella bacteria results in reduction or prevention of the development of airway inflammation in the subject.. ... Institut National De La Sante Et De La Recherche Medicale

08/24/17 / #20170242038

Compositions useful in the diagnostic of latently infected mycobacterium tuberculosis

The present invention concerns a composition comprising at least three peptides derived from mycobacterium tuberculosis antigen rv2626c, its use in the diagnostic of latently infected mycobacterium tuberculosis (ltbi) subjects, corresponding methods of use and kits.. . ... Institut National De La Sante Et De La Recherche Medicale

08/24/17 / #20170241988

New in vitro blood-brain barrier model

The invention is in the domain of delivery of molecules to brain cells across the blood-brain barrier. The invention relates to a novel polypeptide-based carrier that allows the efficient delivery of an effector peptide, to neuron cells across the blood-brain barrier, and to methods for the production and testing of such carrier, including a model for testing the capacity of such molecule to cross the blood-brain barrier and/or the toxicity of molecules on the blood brain barrier and/or the capacity of molecules that have crossed to target human brain cells (e/g. ... Institut National De La Sante Et De La Recherche Medicale

08/24/17 / #20170240583

Bola-amphiphilic compounds and their uses for biomedical applications

The invention relates to bola-amphiphilic compounds and their uses for biomedical application. The invention particularly relates to the use of bola-amphiphilic compounds for providing low molecular weight gels (lmwg), useful, in particular, as culture media for animal or human cells, or as biocompatible material for biomedical applications.. ... Institut National De La Sante Et De La Recherche Medicale

07/06/17 / #20170190687

Imidazol- or 1,2,4-triazol-derivatives and their use

The present invention is directed to novel compounds of formula (i), pharmaceutically acceptable salts or solvates thereof, and their use.. . ... Institut National De La Sante Et De La Recherche Medicale

06/22/17 / #20170175196

Diagnosis of hereditary spastic paraplegias (hsp) by detection of a mutation in the kiaa1840 gene or protein

An ex vivo method of diagnosing or predicting an hereditary spastic paraplegias (hsp) in a subject is provided which comprises detecting a mutation in the kiaa1840 gene or protein (spatacsin), wherein that mutation is indicative of an hereditary spastic paraplegias (hsp).. . ... Institut National De La Sante Et De La Recherche Medicale

06/22/17 / #20170174716

Fumarate-co-releasing molecule hybrids, their use in the treatment of inflammatory or cardiovascular diseases and their process of preparation

The present invention relates to hybrid fumarate-co-releasing molecules capable of increasing heme oxygenase-1 (ho-1) activity and ho-1 protein expression and simultaneously releasing co, their synthesis and their use in therapeutic applications, in particular their use in the treatment of inflammatory or cardiovascular diseases.. . ... Institut National De La Sante Et De La Recherche Medicale

06/15/17 / #20170166643

Recombinant monovalent antibodies

The invention relates to recombinant monovalent antibodies which are heterodimers of a first protein chain comprising the variable domain of the heavy chain of an antibody of interest and the ch2 and ch3 domains of an igg immunoglobulin and a second protein chain comprising the variable domain of the light chain of said immunoglobulin of interest and the ch2 and ch3 domains of said igg immunoglobulin. These antibodies can be used in particular as therapeutic agents in all cases where monovalent binding to a ligand such a cellular receptor is required.. ... Institut National De La Sante Et De La Recherche Medicale

05/04/17 / #20170124294

Method of characterizing molecular diffusion within a body from a set of diffusion-weighted magnetic resonance signals and apparatus for carrying out such a method

A computer-implemented method of characterizing molecular diffusion within a body from a set of diffusion-weighted magnetic resonance signals by computing a weighted average of a plurality of multi-compartment diffusion models comprises a same number of compartments, fitted to a set of diffusion-weighted magnetic resonance signals, the weighted average being computed using weights representative of a performance criterion of each of the models; wherein each of the multi-compartment diffusion models comprises a different number of subsets of compartments, the compartments of a same subset being identical to each other.. . ... Institut National De La Sante Et De La Recherche Medicale

04/06/17 / #20170095513

Methods of generating corneal cells and cell populations comprising same

A method of generating a population of corneal epithelial cells is disclosed. The method comprises culturing human pluripotent stem cells in corneal fibroblast-conditioned medium on a solid surface comprising an extracellular matrix component thereby generating the population of corneal epithelial cells. ... Institut National De La Sante Et De La Recherche Medicale

03/16/17 / #20170074891

Detection of shed cd31, diagnosis of atherothrombosis and autoimmune disorders, and methods for analyzing signaling pathways

The present invention stems from the finding that the extracellular domain of cd31 proteins present on blood leukocytes is shed and released in the circulation as a soluble form of cd31. A method for detecting shed cd31 is further disclosed. ... Institut National De La Sante Et De La Recherche Medicale

03/02/17 / #20170056500

Fkbp52-tau interaction as a novel therapeutical target for treating the neurological disorders involving tau dysfunction

The invention relates generally to neuroprotection and repair in neurological disorders involving tan dysfunction (including alzheimer's disease). The invention describes and includes a direct interaction between proteins fkbp52 mid tau. ... Institut National De La Sante Et De La Recherche Medicale

02/23/17 / #20170051253

Method and device for conserving viable and functional human polymorphonuclear neutrophils

A method for keeping leukocytes alive ex vivo or in vitro, comprising maintaining the leukocytes in a medium comprising from 3 to 10 mm of glucose, in hypoxic conditions with p(02)≦10 mm hg.. . ... Institut National De La Sante Et De La Recherche Medicale

01/19/17 / #20170014421

Piperazine phenothiazine derivatives for treating spasticity

The present invention relates to piperazine phenothiazine derivatives useful as therapeutic agents for treating spasticity, particularly following an ischemia or traumatic injury, or compression syndrome. The invention further relates to a pharmaceutical composition comprising a compound of the invention for treating spasticity.. ... Institut National De La Sante Et De La Recherche Medicale








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