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Institute For Research In Biomedicine patents


Recent patent applications related to Institute For Research In Biomedicine. Institute For Research In Biomedicine is listed as an Agent/Assignee. Note: Institute For Research In Biomedicine may have other listings under different names/spellings. We're not affiliated with Institute For Research In Biomedicine, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "I" | Institute For Research In Biomedicine-related inventors


Novel vaccines in prevention and treatment of malaria

The present invention provides a pharmaceutical composition, for example a vaccine, which comprises a rifin, which is able to bind to a mutated lair-1 fragment, which broadly binds to erythrocytes infected with plasmodium falciparum. Such a rifin may be useful in the prevention and/or treatment of malaria.. ... Institute For Research In Biomedicine

Proteins comprising a mutated lair-1 fragment and uses thereof

The present invention provides a protein comprising a mutated lair-1 fragment, which broadly binds to erythrocytes infected with plasmodium falciparum. The protein comprising the mutated lair-1 fragment may be useful in the prevention and/or treatment of malaria. ... Institute For Research In Biomedicine

Ultra-potent neutralization of cytokines by multispecific antibodies and uses thereof

The present invention provides multispecific antibodies, and antigen binding fragments thereof, that potently neutralize a cytokine and that may thus be useful in the prevention and/or treatment of inflammatory and/or autoimmune diseases. In particular, the present invention provides a multispecific antibody, or an antigen binding fragment thereof, comprising at least two different domains specifically binding to at least two different, non- overlapping sites in a cytokine and an fc moiety. ... Institute For Research In Biomedicine

Human cytomegalovirus neutralizing antibodies and use thereof

The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hcmv, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hcmv gene ul products. The invention also relates to immortalized b cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. ... Institute For Research In Biomedicine

Genetically modified non-human animals and methods of use thereof

Genetically modified non-human animals are provided that may be used to model human hematopoietic cell development, function, or disease. The genetically modified non-human animals comprise a nucleic acid encoding human il-6 operably linked to an il-6 promoter. ... Institute For Research In Biomedicine

Genetically modified non-human animals and methods of use thereof

The invention relates generally to genetically modified non-human animals expressing human polypeptides and their methods of use.. . ... Institute For Research In Biomedicine

Recombinant metapneumovirus f proteins and their use

Metapneumovirus (mpv) f proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the mpv f proteins and/or nucleic acid molecules can be used to generate an immune response to mpv in a subject. ... Institute For Research In Biomedicine

Human cytomegalovirus neutralizing antibodies and use thereof

The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hcmv, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hcmv gene ul products. The invention also relates to immortalized b cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. ... Institute For Research In Biomedicine

Humanized m-csf mice

Genetically modified mice comprising a nucleic acid sequence encoding a human m-csf protein are provided. Also provided are genetically modified mice comprising a nucleic acid sequence encoding a human m-csf protein that have been engrafted with human cells such as human hematopoietic cells, and methods for making such engrafted mice. ... Institute For Research In Biomedicine

Neutralizing anti-influenza a virus antibodies and uses thereof

The invention relates to antibodies, and antigen binding fragments thereof, that specifically bind to an epitope in the stem region of an influenza a hemagglutinin trimer and neutralize a group 1 subtype and a group 2 subtype of influenza a virus. The invention also relates to nucleic acids that encode, immortalized b cells and cultured single plasma cells that produce, and to epitopes that bind to such antibodies and antibody fragments. ... Institute For Research In Biomedicine

Genetically modified mice and engraftment

A mouse with a humanization of the mil-3 gene and the mgm-csf gene, a knockout of a mrag gene, and a knockout of a mll2rg subunit gene; and optionally a humanization of the tpo gene is described. A rag/ll2rg ko/htpo knock-in mouse is described. ... Institute For Research In Biomedicine

Human cytomegalovirus neutralizing antibodies and use thereof

The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hcmv, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hcmv gene ul products. The invention also relates to immortalized b cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. ... Institute For Research In Biomedicine

Human cytomegalovirus neutralizing antibodies and use thereof

The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hcmv, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hcmv gene ul products. The invention also relates to immortalized b cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. ... Institute For Research In Biomedicine

Human cytomegalovirus neutralizing antibodies and use thereof

The invention relates to neutralizing antibodies, and antibody fragments thereof, having high potency in neutralizing hcmv, wherein said antibodies and antibody fragments are specific for one, or a combination of two or more, hcmv gene ul products. The invention also relates to immortalized b cells that produce, and to epitopes that bind to, such antibodies and antibody fragments. ... Institute For Research In Biomedicine








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