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Integrated Dna Technologies Inc patents


Recent patent applications related to Integrated Dna Technologies Inc. Integrated Dna Technologies Inc is listed as an Agent/Assignee. Note: Integrated Dna Technologies Inc may have other listings under different names/spellings. We're not affiliated with Integrated Dna Technologies Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "I" | Integrated Dna Technologies Inc-related inventors


Crispr/cpf1 systems and methods

This invention pertains to recombinant ascpf1 and lbcpf1 nucleic acids and polypeptides for use in crispr/cpf1 endonuclease systems and mammalian cell lines encoding recombinant ascpf1 or lbcpf1 polypeptides. The invention includes recombinant ribonucleoprotein complexes and crspr/cpf1 endonuclease systems having a suitable ascpf1 crrna is selected from a length-truncated ascpf1 crrna, a chemically-modified ascpf1 crrna, or an ascpf1 crrna comprising both length truncations and chemical modifications. ... Integrated Dna Technologies Inc

Crispr-based compositions and methods of use

This invention pertains to modified compositions for use in crispr systems, and their methods of use. In particular, length-modified and chemically-modified forms of crrna are described for use as a reconstituted guide rna for interaction with cas9 of crispr systems. ... Integrated Dna Technologies Inc

Methods and compositions for the specific inhibition of gene expression by double-stranded rna

The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as for treating diseases caused by the expression of the gene. More particularly, the invention is directed to compositions that contain double stranded rna (“dsrna”), and methods for preparing them, that are capable of reducing the expression of target genes in eukaryotic cells. ... Integrated Dna Technologies Inc

Dna data storage using reusable nucleic acids

Disclosed herein are nucleic acid-based data storage systems and nucleic acid data storage constructs comprising reusable nucleic acid sequences, each representing information carried by a single bit (and, in some embodiments, one or more adjacent bits) within a bit string, and each furthermore representing the position of the single bit within the bit string. Also described are methods for storing data in the nucleic acid-based data storage systems and nucleic acid data storage constructs of the disclosure.. ... Integrated Dna Technologies Inc

S. pyogenes cas9 mutant genes and polypeptides encoded by same

This invention pertains to mutant cas9 nucleic acids and proteins for use in crispr/cas endonuclease systems, and their methods of use. In particular, the invention pertains to an isolated mutant cas9 protein, wherein the isolated mutant cas9 protein is active in a crispr/cas endonuclease system, wherein the crispr/cas endonuclease system displays reduced off-target editing activity and maintained on-target editing activity relative to a wild-type crispr/cas endonuclease system. ... Integrated Dna Technologies Inc

Cleavable hairpin primers

The invention describes composition and methods of use for novel hairpin blocked-cleavable primers. In one embodiment unblocking occurs through action of rnase h2. ... Integrated Dna Technologies Inc

Rnase h mutants in an emulsion

The invention is directed to methods and kits for performing an rnase h2-mediated cleavage reaction on a sample in an emulsion.. . ... Integrated Dna Technologies Inc

Long nucleic acid sequences containing variable regions

This invention pertains to improved methods for the synthesis of long, double stranded nucleic acid sequences containing difficult to clone or variable regions.. . ... Integrated Dna Technologies Inc

Rnase h-based assays utilizing modified rna monomers

The present invention pertains to novel oligonucleotide compounds for use in various biological assays, such as nucleic acid amplification, ligation and sequencing reactions. The novel oligonucleotides comprise a ribonucleic acid domain and a blocking group at or near the 3′ end of the oligonucleotide. ... Integrated Dna Technologies Inc

Methods for variant detection

The invention can be used to provide a more efficient and less error-prone method of detecting variants in dna, such as snps and indels. The invention also provides a method for performing inexpensive multiplex assays. ... Integrated Dna Technologies Inc

Synthesis of long nucleic acid sequences

The invention provides methods for the synthesis of long oligonucleotides, genes and gene fragments. The methods include the manufacture of genes or gene fragments that can be then inserted into a variety of vectors.. ... Integrated Dna Technologies Inc

Methods for variant detection

The invention can be used to provide a more efficient and less error-prone method of detecting variants in dna, such as snps and indels. The invention also provides a method for performing inexpensive multiplex assays. ... Integrated Dna Technologies Inc

Oligonucleotide-based probes for detection of bacterial nucleases

The present invention relates to a rapid detection of microbial-associated nuclease activity with chemically modified nuclease (e.g., ribonuclease) substrates, and probes and compositions useful in detection assays.. . ... Integrated Dna Technologies Inc

Cleavable primers for isothermal amplification

The invention provides a more efficient and less error-prone method of performing lamp. The invention also provides a method for utilizing an rnase h2-cleavable probe as a technique for generating signal from the reaction, potentially increasing the specificity of the signal generation.. ... Integrated Dna Technologies Inc

07/20/17 / #20170204412

Modifications for antisense compounds

The invention pertains to modifications for antisense oligonucleotides, wherein the modifications are used to improve stability and provide protection from nuclease degradation. The modifications could also be incorporated into double-stranded nucleic acids, such as synthetic sirnas and mirnas.. ... Integrated Dna Technologies Inc

06/08/17 / #20170159054

Methods and compositions for the specific inhibition of gene expression by double-stranded rna

The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as for treating diseases caused by the expression of the gene. More particularly, the invention is directed to compositions that contain double stranded rna (“dsrna”), and methods for preparing them, that are capable of reducing the expression of target genes in eukaryotic cells. ... Integrated Dna Technologies Inc

04/27/17 / #20170114404

Tm-enhanced blocking oligonucleotides and baits for improved target enrichment and reduced off-target selection

The invention is directed to modified oligonucleotide compositions and methods for selectively reducing unwanted nucleic acid contaminants and enriching for desired nucleic acid targets from complex genomic nucleic acid mixtures for sequencing applications. The modified oligonucleotide compositions include one or more modified groups that increase the tm of the resultant oligonucleotide composition.. ... Integrated Dna Technologies Inc

04/27/17 / #20170114379

Dna polymerase mutants having enhanced template discrimination activity

This invention relates to mutant dna polymerases having an enhanced template discrimination activity compared with the corresponding unmodified dna polymerase counterparts, wherein the amino acid sequence of the mutant dna polymerase includes at least one substitution at residue positions structurally and functionally homologous or orthologous positions 783 or 784 of an unmodified taq dna polymerase.. . ... Integrated Dna Technologies Inc

02/16/17 / #20170044537

Crispr-based compositions and methods of use

This invention pertains to modified compositions for use in crispr systems, and their methods of use. In particular, length-modified and chemically-modified forms of crrna and tracrrna are described for use as a reconstituted guide rna for interaction with cas9 of crispr systems. ... Integrated Dna Technologies Inc

02/16/17 / #20170044536

Crispr-based compositions and methods of use

This invention pertains to modified compositions for use in crispr systems, and their methods of use. In particular, length-modified and chemically-modified forms of crrna and tracrrna are described for use as a reconstituted guide rna for interaction with cas9 of crispr systems. ... Integrated Dna Technologies Inc

02/16/17 / #20170044535

Crispr-based compositions and methods of use

This invention pertains to modified compositions for use in crispr systems, and their methods of use. In particular, length-modified and chemically-modified forms of crrna and tracrrna are described for use as a reconstituted guide rna for interaction with cas9 of crispr systems. ... Integrated Dna Technologies Inc

02/16/17 / #20170044507

Modified rnase h enzymes and their uses

The invention provides a provides improvements to assays that employ rnase h cleavage for biological applications related to nucleic acid amplification and detection, where the rnase h has been reversibly inactivated.. . ... Integrated Dna Technologies Inc

02/09/17 / #20170037395

Tailed primer for cloned products used in library construction

This invention pertains to improved methods for the synthesis of long, double stranded nucleic acid sequences containing difficult to clone or variable regions.. . ... Integrated Dna Technologies Inc








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