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Katholieke Universiteit Leuven patents


Recent patent applications related to Katholieke Universiteit Leuven. Katholieke Universiteit Leuven is listed as an Agent/Assignee. Note: Katholieke Universiteit Leuven may have other listings under different names/spellings. We're not affiliated with Katholieke Universiteit Leuven, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "K" | Katholieke Universiteit Leuven-related inventors


Fused bicyclic heteroaromatic derivatives as kinase inhibitors

A series of fused bicyclic heteroaromatic derivatives of formula (ia) or (ib), as defined herein, being selective inhibitors of phosphatidylinositol-4-kinase iiiβ (pi4kiiiβ) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.. . ... Katholieke Universiteit Leuven

Wave-based majority gate device

The disclosed technology generally relates to computation devices, and more particularly to majority gate devices configured for computation based on spin waves. In one aspect, a majority gate device comprises cells that are configurable as spin wave generators or spin wave detectors. ... Katholieke Universiteit Leuven

Double-gate vertical transistor semiconductor device

A semiconductor device is disclosed that includes a substrate and at least a first, second, third, and fourth vertical transistor supported by the substrate. Each transistor comprises a vertical channel, a polarity gate electrode forming a polarity gate adapted to act on a first portion of the channel to affect a polarity of the channel, and a control gate electrode forming a control gate adapted to act on a second portion of the channel to control the electrical conductivity of the channel. ... Katholieke Universiteit Leuven

Non-volatile sram cell using resistive memory elements

A memory cell is disclosed, comprising a static random-access memory, sram, bit cell, a first resistive memory element and a second resistive memory element. The first resistive memory element is connected to a first storage node of the sram bit cell and a first intermediate node, and the second resistive memory element connected to a second storage node of the sram bit cell and a second intermediate node. ... Katholieke Universiteit Leuven

Lithographic mask layer

An example embodiment relates to a method for making a mask layer. The method may include providing a patterned layer on a substrate, the patterned layer including at least a first set of lines of an organic material of a first nature, the lines having a line height, a first line width roughness, and being separated either by voids or by a material of a second nature. ... Katholieke Universiteit Leuven

Method for preparing an asymmetric membrane

The present invention provides a method for the preparation of an asymmetric membranes. More particularly, the new method relates to the use of a crosslinker contacted via vapour or liquid phase with the surface layer of a cast polymer film, followed by the immersion of said film in a coagulation bath. ... Katholieke Universiteit Leuven

Method of releasing graphene from substrate

The disclosed technology generally relates to preparing two-dimensional material layers, and more particularly to releasing a graphene layer from a template substrate. According to an aspect, a method of releasing a graphene layer includes providing a template substrate on which the graphene layer is provided, the method comprising: subjecting the graphene layer and the template substrate to a water treatment by soaking the graphene layer and the template substrate in water such that water is intercalated between the template substrate and the graphene layer; and subjecting the graphene layer and the template substrate to a delamination process, thereby releasing the graphene layer from the template substrate.. ... Katholieke Universiteit Leuven

Compositions for treatment of osteochondral disorders

The application provides biocompatible carriers comprising bone forming and/or cartilage forming cells and methods for making them. The application further provides pharmaceutical compositions comprising said atmps and method of treatments using said atmps. ... Katholieke Universiteit Leuven

Speech recognition system and method using an adaptive incremental learning approach

The present disclosure relates to speech recognition systems and methods using an adaptive incremental learning approach. More specifically, the present disclosure relates to adaptive incremental learning in a self-taught vocal user interface.. ... Katholieke Universiteit Leuven

Semiconductor cell configured to perform logic operations

The disclosed technology generally relates to machine learning, and more particularly to integration of basic machine learning kernels in a semiconductor device. In an aspect, a semiconductor cell is configured to perform one or more logic operations such as one or both of an xnor and an xor operation. ... Katholieke Universiteit Leuven

Demultiplexing method and device

A method is disclosed for demultiplexing a signal. The method comprises receiving the signal being a sum of at least two sub-signals, whereby each sub-signal comprises a different repetitive pattern. ... Katholieke Universiteit Leuven

Method for bonding semiconductor chips to a landing wafer

A method for bonding chips to a landing wafer is disclosed. In one aspect, a volume of alignment liquid is dispensed on a wettable surface of the chip so as to become attached to the surface, after which the chip is moved towards the bonding site on the wafer, the bonding site equally being provided with a wettable surface. ... Katholieke Universiteit Leuven

Method of propagating magnetic domain wall in magnetic devices

The disclosed technology generally relates to magnetic devices, and more particularly to magnetic devices configured to generate a stream of domain walls propagating along an output magnetic bus. In an aspect, a magnetic device includes a magnetic propagation layer, which in turn includes a plurality of magnetic buses. ... Katholieke Universiteit Leuven

Method of patterning an amorphous semiconductor layer

Methods of patterning an amorphous semiconductor layer according to a predetermined pattern via laser ablation with a pulsed laser having a laser wavelength are disclosed. In one aspect, a method may include providing the amorphous semiconductor layer on a substrate, providing a distributed bragg reflector on the amorphous semiconductor layer, wherein the distributed bragg reflector is reflective at the laser wavelength, providing an absorbing layer on the distributed bragg reflector, wherein the absorbing layer is absorptive at the laser wavelength, patterning the absorbing layer by laser ablation, in accordance with the predetermined pattern, patterning the distributed bragg reflector by performing an etching step using the patterned absorbing layer as an etch mask, and etching the amorphous semiconductor layer using the patterned distributed bragg reflector as an etch mask. ... Katholieke Universiteit Leuven

04/19/18 / #20180108734

Semiconductors with increased carrier concentration

Within examples, a semiconductor device includes a first structure that includes a first doped semiconductor material of a first doping type. The semiconductor device further includes a metal in contact with the first structure, and a second structure that includes a second doped semiconductor material of the first doping type in contact with the first structure. ... Katholieke Universiteit Leuven

03/15/18 / #20180071288

Functional cure of retroviral infection

The application relates to methods of curing retroviral infections, i.e. Ensuring remission of retroviral infections, more particularly hiv infections, by administering a compound which is capable of binding to the ledgf/p75 binding pocket of hiv-integrase and inhibiting ledgf/p75-in protein-protein interaction. ... Katholieke Universiteit Leuven

03/08/18 / #20180066241

Pro-apoptotic set and pp2a peptides

The invention provide chimeric peptides comprising a chimeric peptide comprising a cell-penetrating peptide linked to a pro-apoptotic peptide, wherein the pro-apoptotic peptide is derived from, or consists of, a portion of pp2a protein that binds a set protein or is derived from, or consists of, a portion of the set protein that binds pp2a protein.. . ... Katholieke Universiteit Leuven

03/01/18 / #20180061970

Magnetic majority gate device

The disclosed technology relates generally to spintronics, and more particularly to a magnetic majority gate device. In one aspect, a magnetic majority gate device includes a magnetic propagation layer and at least one input transducer. ... Katholieke Universiteit Leuven

01/18/18 / #20180015437

Patterning device

A novel miniaturized and highly automated method for the controlled printing of large arrays of nano- to femtoliter droplets is presented by actively transporting mother droplets over hydrophilic-in-hydrophobic micropatches. The proposed technology consists of single plate or double-plate devices where mother droplets can be actuated and hydrophilic-in-hydrophobic micropatches on one or both plates of the device where nano- to femtoliter droplets are printed. ... Katholieke Universiteit Leuven

01/11/18 / #20180013431

Breakdown-based physical unclonable function

A device and a method for implementing a physically unclonable function is disclosed. In one aspect, the device includes at least one electronic structure including a dielectric. ... Katholieke Universiteit Leuven

01/11/18 / #20180009903

Modulating adipose tissue and adipogenesis

The invention relates to the field of obesity and related metabolic diseases. More specifically, the invention relates to methods of reducing aggrecanase activity or antigen in mammals in order to enhance brown adipose tissue (bat) development, to promote conversion of white adipose tissue (wat) into bat in vivo, and to limit triglyceride accumulation and steatosis in the liver. ... Katholieke Universiteit Leuven

01/04/18 / #20180002282

Mono- or di-substituted indole derivatives as dengue viral replication inhibitors

The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. ... Katholieke Universiteit Leuven

12/14/17 / #20170356013

Causative genes conferring acetic acid tolerance in yeast

The present invention relates to genes conferring acetic acid tolerance in yeast. More specifically, the invention relates to the use of dot5, preferably in combination with cup2 and/or haa1 to obtain acid tolerance in yeast. ... Katholieke Universiteit Leuven

11/30/17 / #20170346149

Tunable magnonic crystal device and filtering method

The present disclosure relates to a tunable magnonic crystal device comprising a spin wave waveguide, a magnonic crystal structure in or on the spin wave waveguide, and a magneto-electric cell operably connected to the magnonic crystal structure. The magnonic crystal structure is adapted for selectively filtering a spin wave spectral component of a spin wave propagating through the spin wave waveguide so as to provide a filtered spin wave. ... Katholieke Universiteit Leuven

11/30/17 / #20170346005

Rare-earth metal oxide resistive random access non-volatile memory device

A resistive random access memory (rram) device and a method of its manufacture are disclosed. The rram device comprises a lower oxygen affinity bottom electrode, a hygroscopic solid-state dielectric layer, comprising hydroxyl groups, and a higher oxygen affinity top electrode. ... Katholieke Universiteit Leuven

11/30/17 / #20170341036

Improved method for synthesis of polyamide composite membranes

The present invention provides a method for the preparation of thin film composite (tfc) membranes, preferably solvent resistant tfc membranes, by interracial polymerization (ifp), more in particular solvent resistant tfc membranes wherein a thin pa-layer is deposited on a porous support membrane. Said method comprises the replacement of the aqueous and/or the organic solvent in the ifp method by an ionic liquid (il) as solvent for the monomers which form said tfc membranes, to alter the top layer morphology, thickness and crosslinking degree.. ... Katholieke Universiteit Leuven

11/30/17 / #20170340287

Method and apparatus for motion correction in ct imaging

A method for the reduction of motion artifacts in a helical ct reconstruction, the method including the steps of: (a) reconstructing from the raw ct data an initial estimate of the 3d attenuation distribution of the object of interest; (b) estimating a pose parameter set of the object for each projection angle; (c) undertaking a motion corrected reconstruction from the measured projections, accounting for the pose changes estimated in (b); (d) iterating steps (b)-(c) until some convergence criterion is met; and (e) making a final reconstruction of diagnostic quality using the pose estimates obtained in the previous steps.. . ... Katholieke Universiteit Leuven

11/23/17 / #20170338752

Electrical machines

A stator or a rotor for use in an electrical machine comprises a composite element having a rigid mass suitable for including at least one magnetostrictive electrode bar, at least one magnetostrictive electrode bar, and a piezoelectric material in between the rigid mass material and the magnetostrictive electrode bars. The rigid mass, the magnetostrictive electrode bars and the piezoelectric material are arranged such that applying a voltage between the rigid mass and one or more magnetostrictive electrodes, causes piezoelectric effects in the piezoelectric material inducing stress in the bi-axial plane of the at least one magnetostrictive bar and an altered permeability of the at least one magnetostrictive bar in a direction perpendicular to the bi-axial stress plane.. ... Katholieke Universiteit Leuven

11/16/17 / #20170331631

A method and device for authentication

A method for authenticating a prover to a verifier, the prover being provided with a proving key paired to a verification key registered with the verifier, wherein the proving key can be obtained by transforming a protected key and a secret (s) using a transformation (e), characterized in that the prover stores the protected key and does not store the corresponding proving key nor the corresponding verification key in clear, with the exception of storage in transient memory.. . ... Katholieke Universiteit Leuven

11/16/17 / #20170330760

Method for manufacturing pillar or hole structures in a layer of a semiconductor device, and associated semiconductor structure

The present disclosure relates to a method for manufacturing pillar or hole structures in a layer of semiconductor device, and associated semiconductor structure. At least one embodiment relates to a method for manufacturing pillar structures in a layer of a semiconductor device. ... Katholieke Universiteit Leuven

11/16/17 / #20170325701

Device and method for controlling acquisition of a signal and a system for acquisition of a signal

Devices, systems, and methods for controlling acquisition of a signal representing a physiological measurement are described herein. An example device comprises: an input for receiving the signal in digital form, wherein the signal has been acquired by means of at least one electrode without galvanic contact between the electrode and the living being and has been processed by circuitry for acquisition of the signal in analog domain to refine the signal before the signal is converted from analog to digital domain; an adaptation decision module, being configured to determine whether a measure of signal quality indicates that an adaptation of the circuitry for acquisition of the signal in analog domain is beneficial for the robustness of the system and/or the quality of the obtained signals; wherein the adaptation decision module, is arranged to output a control signal for controlling a parameter affecting amplifier saturation in processing of the signal.. ... Katholieke Universiteit Leuven

11/09/17 / #20170319610

Means and methods for treatment of early-onset parkinson's disease

This application relates to the field of neurodegenerative diseases, more particularly to the field of parkinson's disease. In particular, the disclosure describes that inhibitors reducing fas activity can be used for treatment of parkinson's disease, in particular, the treatment of patients suffering from parkinson's disease having loss of function mutations in pink1 or parkin genes.. ... Katholieke Universiteit Leuven

10/05/17 / #20170283453

Cofactor analogues for methyltransferases

Cofactor analogues for methyltransferases are disclosed. The compounds are represented by formula (i) wherein r1 is cooh or coo—; x is an organic or inorganic anion carrying one or more negative charges; y and y′ are h, or an alkyl; r2 is nh2, nhboc, or h; and z is s or se. ... Katholieke Universiteit Leuven

09/28/17 / #20170276841

Wavelength-controlled directivity of all-dielectric optical nano-antennas

The disclosure relates to wavelength-controlled directivity of all-dielectric optical nano-antennas. One example embodiment is an optical nanoantenna for directionally scattering light in a visible or a near-infrared spectral range. ... Katholieke Universiteit Leuven

09/21/17 / #20170271185

Thin film device fabrication methods and apparatus

A deposition device for providing a thin film on a substrate. The device comprises a material source for providing at least one first metallic element which does not re-evaporate substantially from the substrate under particular growth conditions, at least one second metallic element or metal based molecule which does re-evaporate substantially from the substrate under the same growth conditions, and a component suitable for forming an at least one first compound with the at least one first metallic element and an at least one second compound with the at least one second metallic element or metal based molecule. ... Katholieke Universiteit Leuven

09/21/17 / #20170270388

System and method for cell recognition

The present disclosure relates to systems and methods for cell recognition. At least one embodiment relates to a method for recognizing cell. ... Katholieke Universiteit Leuven

09/14/17 / #20170263475

Hot jet assisted systems and methods

A heating device for heating the surface of a substrate. The heating device comprises a gas source comprising an inert material supply inert under the operating conditions of the heating device, the gas source being adapted for supplying a hot jet of a gas comprising at least elements of said inert material on the substrate. ... Katholieke Universiteit Leuven

09/14/17 / #20170260586

Gene expression monitoring for risk assessment of apple and pear fruit storage stress and physiological disorders

The present invention is a tool for diagnosis and prediction using biomarker-based risk assessment for chilling-related disorders of rosaceous fruit crops including apple and pear. Provided are methodology and genes whose relative and absolute expression can accurately indicate disorder risk throughout the production and supply chain of these crops. ... Katholieke Universiteit Leuven

09/14/17 / #20170259260

Biological sampling and storage container

The invention relates to a biological sampling and storage container comprising a top cover and a bottom cover adapted to fit onto each other; and a sampling element having a proximal end onto which the top cover fits and a distal end onto which the bottom cover fits, said sampling element further comprising a sampling container comprising a sampling chamber for accepting the biological sample; an aliquoting element removably mounted on and in said sampling container, said aliquoting element comprising a structural element onto which one or more aliquoting chambers are positioned; and optionally, an ejector removably mounted onto said aliquoting element, wherein the ejector comprises an ejector wand fitting into the aliquoting chambers.. . ... Katholieke Universiteit Leuven

08/31/17 / #20170250075

Method of producing transition metal dichalcogenide layer

Method of producing one or more transition metal dichalcogenide (mx2) layers on a substrate, comprising the steps of: obtaining a substrate having a surface and depositing mx2 on the surface using ald deposition, starting from a metal halide precursor and a chalcogen source (h2x), at a deposition temperature of about 300° c. Suitable metals are mo and w, suitable chalcogenides are s, se and te. ... Katholieke Universiteit Leuven

08/10/17 / #20170224658

Mono- or di-substituted indoles as dengue viral replication inhibitors

. . The present invention concerns mono- or di-substituted indole compounds of formula (i) which are useful to prevent or treat dengue viral infections and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. ... Katholieke Universiteit Leuven

07/27/17 / #20170209493

Stem cells for wound healing

. . The present invention provides a method for treating wounds by applying cells as described in this application. In one aspect the method provides treatment for cutaneous wounds. ... Katholieke Universiteit Leuven

07/20/17 / #20170207217

Finfet having locally higher fin-to-fin pitch

The disclosed technology generally relates to semiconductor devices, and more particularly to finfet transistors. In one aspect, at least three fins are arranged to extend in parallel in a first direction and are laterally separated from each other in a second direction by shallow trench isolation structures having a first fin spacing, where at least a portion of each fin protrudes out from a substrate. ... Katholieke Universiteit Leuven

07/13/17 / #20170198393

Method of producing a thin metal-organic framework film using vapor phase precursors

A method of producing a metal-organic framework (mof) film on a substrate is disclosed, the method comprising providing a substrate having a main surface and forming on said main surface a mof film using an organometallic compound precursor and at least one organic ligand, wherein each of said organometallic compound precursor and said at least one organic ligand is provided only in vapour phase.. . ... Katholieke Universiteit Leuven

07/06/17 / #20170194283

Method for self-aligned solder reflow bonding and devices obtained thereof

A method for producing a stack of semiconductor devices and the stacked device obtained thereof are disclosed. In one aspect, the method includes providing a first semiconductor device comprising a dielectric layer with a hole, the hole lined with a metal layer and partially filled with solder material. ... Katholieke Universiteit Leuven

07/06/17 / #20170191087

Causative genes conferring acetic acid tolerance in yeast

The present invention relates to the use of glo1 to modulate acetic acid tolerance in yeast. More specifically, it relates to the use of a specific glo1 allele to confer tolerance to acetic acid, and to improve the fermentation performance of yeast in the presence of acetic acid.. ... Katholieke Universiteit Leuven

07/06/17 / #20170190978

Biphasic solvent catalytic process for the direct production of light naphtha from carbohydrate-containing feedstock

The disclosure describes a one-step liquid biphasic catalytic process for converting a carbohydrate-containing feedstock, preferably lignocellulose, to light naphtha (e.g., hexane, pentane, methyl cyclopentane, cyclohexane, etc.) in the presence of an acidic reactive aqueous phase and a redox catalyst in the organic extracting/reaction phase. The process provides a cost-effective route for producing light-naphtha components, in presence or not of deoxygenates. ... Katholieke Universiteit Leuven

06/29/17 / #20170186733

Method for aligning micro-electronic components

Alignment of a first micro-electronic component to a receiving surface of a second micro-electronic component is realized by a capillary force-induced self-alignment, combined with an electrostatic alignment. The latter is accomplished by providing at least one first electrical conductor line along the periphery of the first component, and at least one second electrical conductor along the periphery of the location on the receiving surface of the second component onto which the component is to be placed. ... Katholieke Universiteit Leuven

06/22/17 / #20170179337

Optical semiconductor device and method for making the device

. . An optical semiconductor device comprises, on a substrate, a fin of diamond-cubic semiconductor material and, at the base of the fin, a slab of that semiconductor material, in a diamond-hexagonal structure, that extends over the full width of the fin, the slab being configured as an optically active material. This semiconductor material can contain silicon. ... Katholieke Universiteit Leuven

06/22/17 / #20170179263

Two-dimensional material semiconductor device

A semiconductor device comprises a two-dimensional (2d) material layer, the 2d material layer comprising a channel region in between a source region and a drain region; a first gate stack and a second gate stack in contact with the 2d material layer, the first and second gate stack being spaced apart over a distance; the first gate stack located on the channel region of the 2d material layer and in between the source region and the second gate stack, the first gate stack arranged to control the injection of carriers from the source region to the channel region and the second gate stack located on the channel region of the 2d material layer; the second gate stack arranged to control the conduction of the channel region.. . ... Katholieke Universiteit Leuven

06/15/17 / #20170170017

Method for patterning a substrate involving directed self-assembly

A method for patterning a substrate is disclosed. The method includes applying a first directed self-assembly (dsa) patterning process that defines a first patterned layer on top of the substrate. ... Katholieke Universiteit Leuven

06/15/17 / #20170170007

Method for pattern formation on a substrate, associated semiconductor devices, and uses of the method

The present disclosure relates to a method for pattern formation on a substrate. An example embodiment includes a method for pattern formation. ... Katholieke Universiteit Leuven

06/15/17 / #20170169873

Three transistor two junction magnetoresistive random-access memory (mram) bit cell

Three transistor two junction magnetoresistive random-access memory (mram) bit cells are disclosed. An example mram bit cell includes a first magnetic tunnel junction, mtj, connected to a first bit line. ... Katholieke Universiteit Leuven

06/08/17 / #20170158684

Novel compound, pharmaceutically acceptable salt or optical isomer thereof, method for preparing the same, and pharmaceutical composition for prevention or treatment of viral diseases containing same as active ingredient

The present invention relates to a novel compound, to a pharmaceutically acceptable salt or optical isomer thereof, to a method for preparing same, and to a pharmaceutical composition for the prevention or treatment of viral diseases containing same as an active ingredient. The novel compound according to the present invention not only has low cytotoxicity but also has excellent antiviral activity against picornavirus such as coxsackievirus, enterovirus, echovirus, poliovirus and rhinovirus, and thus can be effectively used as a pharmaceutical composition for the prevention or treatment of viral diseases such as infantile paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis a, myitis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, cold, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinus infection, or otitis media.. ... Katholieke Universiteit Leuven

06/01/17 / #20170152271

Gak modulators as antivirals

The present invention relates to the use of a class of novel isothiazolo[4,3-b]pyridine derivatives as well as to pharmaceutical compositions comprising one or more of said isothiazolo[4,3-b]pyridine derivatives and one or more pharmaceutically acceptable excipients as biologically active ingredients, more specifically as medicaments for the treatment of disorders and pathologic conditions such as viral diseases.. . ... Katholieke Universiteit Leuven

05/18/17 / #20170137502

Phosphospecific antibodies recognising tau

The present invention relates to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with neurofibrillary tangles. In particular, the invention relates to antibodies, which specifically recognize and bind to phosphorylated pathological protein tau-conformers and to methods and compositions involving said antibodies for the therapeutic and diagnostic use in the treatment of tauopathies including alzheimer's disease (ad).. ... Katholieke Universiteit Leuven

05/11/17 / #20170133853

Methods and devices for increasing the voltage gain range of a dc-dc power converter

Circuits and methods for increasing the voltage gain range of a dc-dc power converter include: two multiplier stages, each comprising two capacitors, each capacitor respectively connected to a diode, which are adapted to charge the capacitors with a voltage; at least two switching devices arranged to interchangeably operate between the at least two multiplier stages, or arranged to selectively connect the at least two multiplier stages in series in a first mode of operation and to at least partly bypass one of the at least two multiplier stages in a second mode of operation, thereby increasing the voltage gain range of the dc-dc power converter.. . ... Katholieke Universiteit Leuven

05/11/17 / #20170129905

Fused bicyclic heteroaromatic derivatives as kinase inhibitors

A series of fused bicyclic heteroaromatic derivatives of formula (ia) or (ib), as defined herein, being selective inhibitors of phosphatidylinositol-4-kinase iiiβ (pi4kiiiβ) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.. . ... Katholieke Universiteit Leuven

05/04/17 / #20170125789

Methods for forming lithium manganese oxide layers

A method is provided for forming a porous, electrochemically active lithium manganese oxide layer on a substrate, the method comprising: depositing a porous manganese oxide layer on the substrate; providing a li containing layer on the porous manganese oxide layer; and afterwards performing an annealing step at a temperature in the range between 200° c. And 400° c., thereby inducing a solid-state reaction between the porous manganese oxide layer and the li containing layer. ... Katholieke Universiteit Leuven

05/04/17 / #20170121529

Solvent resistant polymeric membranes

A radiation curable composition for preparing a polymeric membrane includes a) a membrane polymer selected from the group consisting of a polysulfone (psu), a polyether sulfone (pes), a polyether etherketone (peek), a polyvinylchloride (pvc), a polyacrylonitrile (pan), a polyvinylidene fluoride (pvdf), a polyimide (pi), a polyamide (pa) and copolymers thereof; b) a hydrophobic monomer or oligomer having at least two free radical polymerizable groups independently selected from the group consisting of an acrylate group, a methacrylate group, an acrylamide group, a methacrylamide group, a styrene group, a vinyl ether group, a vinyl ester group, a maleate group, a fumarate group, an itaconate group, and a maleimide group; and c) an organic solvent for the membrane polymer and the hydrophobic monomer. A polymeric membrane and a method for manufacturing the membrane are also disclosed.. ... Katholieke Universiteit Leuven

05/04/17 / #20170121337

Fused bicyclic heteroaromatic derivatives as kinase inhibitors

A series of fused bicyclic heteroaromatic derivatives of formula (i), as defined herein, being selective inhibitors of phosphatidylinositol-4-kinase iiiβ (pi4kiiiβ) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.. . ... Katholieke Universiteit Leuven

05/04/17 / #20170121324

Pyrazolo-pyridine derivatives as kinase inhibitors

A series of pyrazolo[3,4-b]pyridine derivatives that are substituted at the 4-position by a diaza monocyclic, bridged bicyclic or spirocyclic moiety, being selective inhibitors of phosphatidylinositol-4-kinase iiiβ (pi4kiiiβ) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.. . ... Katholieke Universiteit Leuven

03/16/17 / #20170076772

Magnetic topological soliton detection

A solid-state device configured to generate an electric signal indicative of a presence or an absence of a magnetic topological soliton is disclosed. The solid-state device includes a storage element configured to store a magnetic topological soliton. ... Katholieke Universiteit Leuven

03/09/17 / #20170065937

Solvent resistant thin film composite membrane and its preparation

The present invention relates to improved methods for synthesis of thin film composite membranes by interfacial polymerization. More in particular, the method of the present invention comprises the impregnation of an ultrafiltration porous support membrane with an aqueous solution containing a polyfunctional nucleophilic monomer, and contacting the impregnated support membrane with a second largely water-immiscible solvent containing a polyfunctional epoxide monomer.. ... Katholieke Universiteit Leuven

03/02/17 / #20170061619

Analysis and sorting of objects in flow

A device and method for sorting objects immersed in a flowing medium are disclosed. An example device comprises a holographic imaging unit comprising one or more holographic imaging elements, a fluid handling unit comprising one or more microfluidic channels configured to conduct flowing medium along a corresponding holographic imaging element and at least one microfluidic switch arranged downstream of an imaging region in the microfluidic channel configured to direct objects in the flowing medium into a one of a plurality of outlets. ... Katholieke Universiteit Leuven

02/23/17 / #20170052452

Method for verifying a pattern of features printed by a lithography process

The disclosure relates to a method for verifying a printed pattern. In an example embodiment, the method includes defining sectors of at least a portion of the features in the reference pattern, determining a contour of the printed pattern, and superimposing the contour of the printed pattern on the reference pattern. ... Katholieke Universiteit Leuven

01/26/17 / #20170022242

Novel antiviral and antitumoral compounds

The present invention relates to novel phosphate-modified nucleosides, such as phosphoramidate nucleosides. The invention also relates to the use of these novel phosphate-modified nucleosides to treat or prevent viral infections and proliferative diseases (such as cancer) and their use to manufacture a medicine to treat or prevent viral infections and proliferative diseases particularly infections with viruses belonging to the hcv family.. ... Katholieke Universiteit Leuven

01/19/17 / #20170017148

Method for designing a lithographic mask

The disclosure is directed to a method for designing a lithographic mask to print a pattern of structural features, wherein an opc-based methodology may be used for producing one or more simulated patterns as they would be printed through the optimized mask. A real mask is then produced according to the optimized design, and an actual print is made through the mask. ... Katholieke Universiteit Leuven

01/19/17 / #20170016071

Oxidative stress and cardiovascular disease events

The present invention relates to diagnosis and/or prognosis of cardiovascular disease and cardiovascular events. A prognostic risk score in relation to the cardiovascular events, more particular after intervention, can be determined by counting the number of deregulated genes (or derived proteins) in their isolated monocytes. ... Katholieke Universiteit Leuven

01/12/17 / #20170010281

Biomarker panel for assessment of mucosal healing

The present invention provides methods for predicting the likelihood of mucosal healing in an individual with inflammatory bowel disease (ibd), including crohn's disease and ulcerative colitis (uc). In addition, the present invention provides methods for monitoring the progression of mucosal healing in an individual with a disease such as ibd. ... Katholieke Universiteit Leuven

01/12/17 / #20170009229

Inhibition of neat1 for treatment of solid tumors

The application relates to the field of cancer, particularly to the field of solid tumors. It was found that a particular long non-coding rna (lncrna), neat1, an essential architectural component of nuclear paraspeckles, is required for the survival of cancer, but not that of normal, non-transformed, cells. ... Katholieke Universiteit Leuven

01/05/17 / #20170000368

Sensing device with array of microelectrodes

Devices and systems described herein relate to a sensing device that includes an output area and an electrode area. The output area includes an output circuit comprising an integrator adapted to integrate a received current so as to generate an output voltage corresponding to the received current. ... Katholieke Universiteit Leuven








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