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Knopp Biosciences Llc patents


Recent patent applications related to Knopp Biosciences Llc. Knopp Biosciences Llc is listed as an Agent/Assignee. Note: Knopp Biosciences Llc may have other listings under different names/spellings. We're not affiliated with Knopp Biosciences Llc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "K" | Knopp Biosciences Llc-related inventors


Compositions and methods for treating amyotrophic lateral sclerosis in responders

A method for treating amyotrophic lateral sclerosis (als) in a subject in need thereof comprising administering to said subject an effective amount of (6r)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole or pharmaceutically acceptable salt thereof, wherein said subject is a treatment responder. In certain embodiments, said subject is a subject with definite amyotrophic lateral sclerosis, a subject with amyotrophic lateral sclerosis symptom onset duration of less than about 18 months, a subject with a high level of serum creatinine, a subject with concomitant riluzole administration and combinations thereof.. ... Knopp Biosciences Llc

Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils

Disclosed herein are methods of treating conditions, which may be associated with elevated levels of eosinophils and/or basophils, with a therapeutically effective amount of dexpramipexole or pharmaceutical acceptable salt thereof.. . ... Knopp Biosciences Llc

Compositions and methods for treating conditions related to elevated levels of eosinophils and/or basophils

Disclosed herein are methods of treating conditions, which may be associated with elevated levels of eosinophils and/or basophils, with a therapeutically effective amount of dexpramipexole or pharmaceutical acceptable salt thereof.. . ... Knopp Biosciences Llc

Benzoimidazol-1,2-yl amides as kv7 channel activators

Optionally substituted benzoimidazol-1,2-yl amides, such as compounds of formula 1 or formula 2, can be used to treat disorders associated with a kv7 potassium channel activator. Compositions, medicaments, and dosage forms related to the treatment are also disclosed herein.. ... Knopp Biosciences Llc

Compositions and methods for treating chronic urticaria

Disclosed herein are methods of treating conditions, which may be associated with elevated levels of mast cells, basophils, eosinophils, or a combination thereof, with a therapeutically effective amount of dexpramipexole or pharmaceutical acceptable salt thereof.. . ... Knopp Biosciences Llc

Compositions and methods for treating amyotrophic lateral sclerosis in responders

A method for treating amyotrophic lateral sclerosis (als) in a subject in need thereof comprising administering to said subject an effective amount of (6r)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole or pharmaceutically acceptable salt thereof, wherein said subject is a treatment responder. In certain embodiments, said subject is a subject with definite amyotrophic lateral sclerosis, a subject with amyotrophic lateral sclerosis symptom onset duration of less than about 18 months, a subject with a high level of serum creatinine, a subject with concomitant riluzole administration and combinations thereof.. ... Knopp Biosciences Llc

Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders

Disclosed herein are methods of treating conditions, which may be associated with elevated levels of plasma cells and/or b-cells, with a therapeutically effective amount of dexpramipexole or pharmaceutical acceptable salt thereof.. . ... Knopp Biosciences Llc

Imidazo(4,5-b) pyridin-2-yl amides as kv7 channel activators

Compounds represented by formula 1 can be potent and/or partially selective for the kv7.2/7.3 heteromultimer. They may be useful in treating disorders related to seizures, pain, neurotransmitter release, etc.. ... Knopp Biosciences Llc

Synthesis of chirally purified substituted benzothiazole diamines

Methods for preparing chirally purified substituted 4,5,6,7-tetrahydro-benzotiazole diamines such as, for example, (6r)2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole and purifying a dominant enantiomer of substituted 4,5,6,7-tetrahydro-benzotiazole diamines from entantiomerically enriched mixtures of substituted 4,5,6,7-tetrahydro-benzotiazole diamines are provided herein.. . ... Knopp Biosciences Llc

Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds

The present invention is related to an improved process for the preparation of amino-substituted 4,5,6,7-tetrahydrobenzothiazole compounds of formula i, such as the compound 2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention further relates to an improved synthesis of (r)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. ... Knopp Biosciences Llc

Benzoimidazol-1,2-yl amides as kv7 channel activators

Optionally substituted benzoimidazol-1,2-yl amides, such as compounds of formula 1 or formula 2, can be used to treat disorders associated with a kv7 potassium channel activator. Compositions, medicaments, and dosage forms related to the treatment are also disclosed herein.. ... Knopp Biosciences Llc








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