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Lonza Inc patents


Recent patent applications related to Lonza Inc. Lonza Inc is listed as an Agent/Assignee. Note: Lonza Inc may have other listings under different names/spellings. We're not affiliated with Lonza Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "L" | Lonza Inc-related inventors


Dynamically controlling an automated system

. . Systems and methods for dynamic automation are provided. An automation module, for example, may receive at least one map template that is selectable by a user. ... Lonza Inc

Methods and systems for using a virtual or augmented reality display to perform industrial maintenance

A method of providing a virtual reality or augmented reality display is provided. The method includes generating, with a camera of a device, first video content (e.g., a first video stream) that may include a depiction of a component of a facility for the processing of a pharmaceutical product, e.g., a biological product and detecting or selecting the component (e.g., a vessel, a pipe between a holding tank and a filter). ... Lonza Inc

Coagulogen-free clarified limulus amebocyte lysate

The present invention is related to compositions comprising clarified limulus amebocyte lysate (lal), wherein the lal is substantially free of coagulogen and methods of making such compositions. The invention further relates to a method of detecting an endotoxin in a sample using a chromogenic assay, the method comprising: (a) contacting the sample with a reagent comprising clarified lal and a chromogenic substrate; and (b) measuring a chromogenic effect resulting from a change in the chromogenic substrate in the presence of endotoxin in the sample, wherein the lal is substantially free of coagulogen. ... Lonza Inc

Passaging and harvesting formulation and method for human pluripotent stem cells

Formulations and methods are disclosed for the harvesting and subsequent passaging of human pluripotent stem cells without the use of enzymes and/or scraping to dislodge cells from cell culture vessels. The formulations and methods permit the harvesting of cells as large clusters from the surface of various cell culture vessels including multilayer cell culture vessels. ... Lonza Inc

Rupture disks for bioreactors and methods of using same

A rupture disk includes a body including an internal wall extending from a first end of the body to a second end of the body. The internal wall defines an opening extending through the body. ... Lonza Inc

Foaming agent composition and method for removing hydrocarbon liquids from subterranean wells

A composition containing a quaternary organosilane foaming agent capable of foaming various liquids in order to remove the liquids from subterranean wells is described. For instance, the composition can be used to remove hydrocarbon condensate liquids from a gas well or an oil well. ... Lonza Inc

Method for the reduction of viral titer in pharmaceuticals

Disclosed are methods and devices for the optimization of virus removal from solutions. A method of filtering a process fluid comprising a product includes allowing some of the process fluid to flow from a first reservoir to a viral filter; adding a chase fluid to the process fluid in the first reservoir to form a composite fluid; and allowing the composite fluid to flow from the first reservoir to the viral filter to produce eluent. ... Lonza Inc

Antibodies

Antibodies having modified constant regions so as to permit conjugation of the antibody to a payload such as a therapeutic agent are described. Preferred antibodies include a mutation at light chain position 180 (positional numbering), most preferably the mutation is to a residue selected from c, k, q, or a non-natural amino acid. ... Lonza Inc

Method for preparation of bis(fluorosulfonyl)-imide

The invention relates to a method for the preparation of bis(fluorosulfonyl)-imide and its derivatives at elevated temperature.. . ... Lonza Inc

Expression sequences

An isolated nucleic acid encoding a leader, which has a specific sequence, an isolated leader peptide encoded by such nucleic acid, an expression cassette comprising such nucleic acid encoding a leader operably linked to a nucleic acid sequence encoding a poi, a recombinant yeast host cell or a vector comprising such expression cassette, a method of producing a poi in such yeast host cell, and further the use of the specific nucleic acid for the secretion of a poi from a host cell and/or to increase the secretion of a poi from a host cell.. . ... Lonza Inc

Disinfectant composition having residual biocidal properties

A composition having biocidal properties is disclosed. The composition includes a biocide in combination with a film forming component. ... Lonza Inc

Reactor surface finish remediation

Improved biopharmaceutical processing equipment such as reactor vessels and stainless steel surfaces, and methods of determining the same are disclosed herein. In some embodiments, a biopharmaceutical processing equipment can include a vessel having a surface that is configured to contact proteinaceous processing material, wherein the surface has a pre-commissioning surface roughness of greater than about 20 ra max (μin).. ... Lonza Inc

Low residue disinfecting wipes

The present disclosure is directed to a wiping composition. The composition contains a quaternary ammonium compound in a concentration sufficient to have antimicrobial efficacy. ... Lonza Inc

Enhanced biocide composition containing an isothiazolinone and a pyrithione

The present disclosure is directed to an enhanced biocide composition containing an isothiazolinone and a pyrithione. In particular, the composition contains an isothiazolinone, a pyrithione, a zinc compound, and an organic amine. ... Lonza Inc

03/08/18 / #20180066400

Treatment composition containing a mold inhibiting agent and a water repellent having reduced foaming properties

The present disclosure is generally directed to a mold inhibiting composition. The mold inhibiting composition can be used to treat various different substrates, including building material products, such as facing layers for wallboard. ... Lonza Inc

02/08/18 / #20180038864

Method of detecting an endotoxin using limulus amebocyte lysate substantially free of coagulogen

The present invention is related to a method of detecting an endotoxin in a sample using a chromogenic assay, the method comprising: (a) contacting the sample with a reagent comprising limulus amebocyte lysate (lal) and a chromogenic substrate; and (b) measuring a chromogenic effect resulting from a change in the chromogenic substrate in the presence of endotoxin in the sample; wherein the lal is substantially free of coagulogen. The method also relates to compositions and kits comprising lal substantially free of coagulogen, and methods of making such.. ... Lonza Inc

02/08/18 / #20180037861

Method and system for providing buffer solutions

A method for delivering a processing solution includes providing a concentrated processing solution in a bioprocess container, the concentrated processing solution being produced at a first site. The method also includes combining the concentrated processing solution with a biopolymer containing solution produced in a bioreactor at a second site different from the first site. ... Lonza Inc

01/11/18 / #20180010082

Bioreactor with higher agitation rates

A single-use bioreactor is provided. The single-use bioreactor may include a bioprocess container, a shell, at least one agitator, at least one sparger, at least one gas filter inlet port for the sparger(s) and headspace overlay, at least one fill port, at least one harvest port, at least one sample port, and at least one probe. ... Lonza Inc

12/28/17 / #20170369828

Variable diameter bioreactors

. . A variable diameter bioreactor vessel is provided that includes a first vessel section having a first diameter configured to hold a liquid media and biologic material, and a second vessel section having a second diameter that is greater than the first diameter such that the liquid media can be increased from a first volume to a second volume within the vessel.. . ... Lonza Inc

12/28/17 / #20170367331

Preservative composition for wet wipes

A wiping composition and a wiping product containing the composition are disclosed. The wiping composition contains a combination of an antimicrobial agent with a preservative enhancing agent that not only provides antiseptic properties when applied to an adjacent surface, but also is well suited to preserving the substrate that is used to apply the composition. ... Lonza Inc

12/14/17 / #20170356022

Method for stabilizing proteins

The present disclosure features methods and compositions for increasing the amount of products of cellular metabolism, e.g., proteins, by lowering the temperature of cells expressing the product at one or more steps while culturing the cells, expressing the product, and/or recovering the product.. . ... Lonza Inc

12/14/17 / #20170356007

Expression vectors comprising chimeric cytomegalovirus promoter and enhancer sequences

The present invention relates to expression vectors for the heterologous expression of a nucleic acid sequence of interest in mammalian cells, the vectors comprising a chimeric promoter regulatory sequence being operably linked to a nucleic acid sequence to be expressed, wherein the chimeric promoter regulatory sequence comprises a cytomegalovirus promoter sequence derived from murine cytomegalovirus or from human cytomegalovirus and being operably linked to the transcriptional start site of the nucleic acid sequence to be expressed; and a cytomegalovirus upstream region and/or enhancer sequence derived from human and/or the simian cytomegalovirus, wherein the upstream region and/or enhancer sequence is located 5′ of and operably linked to the murine or the human promoter sequence, and wherein the chimeric promoter regulatory sequence comprises sequence elements being derived from at least two of the group consisting of murine cytomegalovirus, human cytomegalovirus and simian cytomegalovirus. In particular embodiments, the chimeric promoter regulatory sequence comprises sequence elements derived from the murine or the human cytomegalovirus ie1 promoter and from the human and/or the simian cytomegalovirus ie1 region. ... Lonza Inc

12/07/17 / #20170349874

Single use bioreactor

A single-use bioreactor is provided. The single-use bioreactor may include a bioprocess container, a shell, at least one agitator, at least one sparger, at least one gas filter inlet port for the sparger(s) and headspace overlay, at least one fill port, at least one harvest port, at least one sample port, and at least one probe. ... Lonza Inc

11/16/17 / #20170326520

Fluid mixing structure, continuous reaction unit, continuous reaction reactor and method of using the same

A fluid mixing structure (10) for mixing at least two fluidic components has a flow inlet port and a flow outlet port and comprises a contraction zone (12), an expansion zone (14), and a retention zone (16), arranged in this order in an inflow direction (ifd) of a fluid flow to flow through said fluid mixing structure (10) and being composed of said at least two fluidic components, and a flow splitter (32) arranged in a space (30) formed by said expansion zone (14) and said retention zone (16) to split said fluid flow in a first sub fluid flow and a second sub fluid flow flowing in a first flow path and a second flow path, respectively, formed in the fluid mixing structure, and to mix said first and second sub fluid flows within said space (30) to generate and discharge a homogenized fluid flow, wherein said flow splitter (32) is arranged and configured to let any flow element of each of said first and second sub fluid flows prior to their mixing have a non-zero average flow component in said inflow direction (ifd).. . ... Lonza Inc

11/09/17 / #20170321443

Customizable facility

A campus for fabricating at least one pharmaceutical product has one or more customizable facilities each configured to manufacture the at least one pharmaceutical product, a media/buffer plant, and a utility building connected by a utility line to the media/buffer plant and/or the one or more customizable facilities to provide at least one first utility to the media/buffer plant and/or the one or more customizable facilities via the utility line.. . ... Lonza Inc

11/09/17 / #20170321194

Modulation of lipid metabolism for protein production

The present disclosure features methods and compositions for modulating lipid metabolism to achieve improved production and quality of recombinant products, such as next generation biologics. Modulation of lipid metabolism as described herein includes, for example, introducing a lipid metabolism modulator described herein to a cell or a cell-free system. ... Lonza Inc

11/09/17 / #20170320878

Method for preparation of fluoro, chloro and fluorochloro alkylated compounds by homogeneous catalysis

The invention discloses a method for preparation of fluoro, chloro and fluorochloro alkylated compounds by homogeneous pd catalyzed fluoro, chloro and fluorochloro alkylation with fluoro, chloro and fluorochloroalkyl halides in the presence of di(1-adamantyl)-n-butylphosphine and in the presence of 2,2,6,6-tetramethylpiperidine 1-oxyl.. . ... Lonza Inc

10/26/17 / #20170306317

Method and device for uniformly treating adherent cells

Disclosed is a method for subjecting adherent cells to at least one electric field, in which the electric field is generated by applying a voltage to at least two active electrodes 63, wherein at least three electrodes 63, 64 are provided, and wherein at least two electrodes 63, 64 are active electrodes 63 when the voltage is applied in order to generate a first electric field, and in which at least one second electric field is generated, wherein at least one of the two previously active electrodes 63 is a potential-free electrode 64 when the voltage is applied. Also disclosed is a device 58 comprising at least three electrodes 63, 64, which are connected to at least one voltage source by means of at least one switching device 59, 60, 61, 62, wherein at least five electrodes 63, 64 are connected to the at least one voltage source by means of four switching devices 59, 60, 61, 62, wherein at least two electrodes 63, 64 are connected to the voltage source by means of a common switching device 59, 60, 61, 62. ... Lonza Inc

10/05/17 / #20170284605

Dispersants and dissolvers for removal of asphaltene deposits

A cleaning solution for the removal of asphaltene deposits includes a first dispersant comprising a quaternary ammonium compound and a second dispersant comprising a pyridinium compound.. . ... Lonza Inc

09/21/17 / #20170267962

Bioreactor for the cultivation of mammalian cells

The present invention relates to large-scale bioreactors having at least two impellers, large-scale bioreactor systems and methods for the large scale cultivation and propagation of mammalian cells using these bioreactors.. . ... Lonza Inc

09/14/17 / #20170260763

Customizable facility

A customizable facility for manufacturing at least one product has at least one modular unit in communication with at least one central unit configured to provide utilities to the at least one modular unit. In some embodiments, the central unit(s) and modular unit(s) are positioned at least partially within a shell. ... Lonza Inc

08/24/17 / #20170242029

Rapid method for targeted cell (line) selection

The present invention relates to a process for the prediction of cell culture performance data of sample cells, a process for the isolation of said cells and a device for the prediction of cell culture performance data of sample cells.. . ... Lonza Inc

08/17/17 / #20170233716

Device and method for large volume transfection

The invention relates to a device for applying an electric field to a suspension of cells, comprising at least one chamber which comprises at least one internal space (40) for holding the suspension, the internal space (40) comprising at least two segments (41, 42), wherein each segment (41, 42) comprises at least one electrode (43, 44) and wherein neighboring electrodes (43, 44) are separated from each other by at least one gap (47) which is at least partially filled with an insulating material (46), and wherein the edges of the electrodes (43, 44) facing each other within the internal space (40) are rounded. Rounding the electrodes' edges facing a neighboring electrode results in a significant reduction of field gradients and thus even of the risk of arcing. ... Lonza Inc

08/17/17 / #20170233715

Device and method for large volume transfection

The invention relates to a device (1) for applying an electric field to a suspension of cells, cell derivatives, organelles, sub-cellular particles and/or vesicles, comprising at least one chamber (6) which comprises at least two electrodes (4), and at least one separating element (13) which is movable within the chamber (6) between two terminal points (14, 15) and, if it is in a position between the terminal points (14, 15), separates at least one first compartment (26) of the chamber (6) from at least one second compartment (27) of the chamber (6). According to the invention each compartment (26, 27) is designed to hold the suspension and comprises at least one port (7, 8, 10, 11) for charging or discharging the suspension, so as to discharge an aliquot of the suspension from the chamber (6) and at the same time charge a further aliquot of the suspension into the chamber (6), wherein the separating element (13) is moved in a second direction opposite to a first direction, and wherein the separating element (13) separates the aliquots from each other.. ... Lonza Inc

08/10/17 / #20170226483

Methods and vectors to produce vector free induced pluripotent stem cells

The invention relates generally to methods of generating induced pluripotent stem cells (ipscs) that do not contain the reprogramming vector. In some embodiments, the invention relates to inducing pluripotency in somatic cells by introducing an episomal vector(s) comprising at least one expression cassette containing reprogramming factors and/or synthetic transcription factors and a suicide gene. ... Lonza Inc

06/22/17 / #20170173050

Method and composition for increasing muscle protein synthesis and/or functional strength in mammals

A method and composition for preserving muscle mass and function by increasing muscle protein synthesis and/or decreasing muscle protein degradation in mammals is disclosed. In one embodiment, the mammals are administered a protein building composition comprising at least two of an essential amino acid, an amino acid derivative, and a nitrogenous organic acid. ... Lonza Inc

06/08/17 / #20170158695

Method for preparation of alkylated or fluoro, chloro and fluorochloro alkylated compounds by heterogeneous catalysis

The invention discloses a method for preparation of alkylated or fluoro, chloro and fluorochloro alkylated compounds by a heterogeneous pt/c-catalyzed alkylation or fluoro, chloro and fluorochloro alkylation with alkyl halides or with fluoro, chloro and fluorochloro alkyl halides in the presence of cs2c03 or cshc03.. . ... Lonza Inc

05/18/17 / #20170137830

Regulation of inducible promoters

The present invention relates to the production of heterologous polypeptides in a recombinant bacterial host cell, wherein the bacterial host cell is rendered unable to deactivate the promoter controlling the expression of the heterologous polypeptide in the absence of an inducer.. . ... Lonza Inc

05/18/17 / #20170137359

Method for preparation of 4-alkoxy-1,1,1-trifluorobut-3-en-2-ones from 1,1,1-trifluoroacetone

The invention discloses a method for the preparation of 4-alkoxy-1,1,1-trifluorobut-3-en-2-ones from 1,1,1-trifluoroacetone.. . ... Lonza Inc

05/11/17 / #20170130283

Method for preserving hides or skins

A process for preserving raw/fresh hides and skins is disclosed. In one embodiment, the hides and skins are treated with an antimicrobial composition containing a carbonate and/or bicarbonate salt of a quaternary ammonium cation. ... Lonza Inc

05/04/17 / #20170120244

Modular well plates

A filter plate with a flexible modular design. The filter plate has removable and completely closable rows and columns of wells, as well as removable and completely closable single or groups of wells.. ... Lonza Inc

04/20/17 / #20170107476

System and method for regulating cell culture based production of biologics

. . The disclosure is directed to a system and method for control of at least one bioreactor, other cell cultivation-related equipment, and systems containing any combination of these in a plant. For example, a plant-wide control system (pwcs) or a process control system (pcs) may be divided into three main components: hardware (including operating systems, such as a controller communicating with one or more servers of a network associated with the pwcs, (2) software (such as a control module) for performing control, and (3) one or more instrument control loops, which may be used by the software to maintain certain process values. ... Lonza Inc

02/16/17 / #20170044557

Recombinant host cell for expressing proteins of interest

The present invention is in the field of recombinant biotechnology, in particular in the field of protein expression. The invention generally relates to a method of expressing a protein of interest (poi) from a host cell. ... Lonza Inc

02/09/17 / #20170037418

Regulatable promoter

A method of producing a protein of interest (poi) by culturing a recombinant eukaryotic cell line comprising an expression construct comprising a regulatable promoter and a nucleic acid molecule encoding a poi under the transcriptional control of said promoter, comprising the steps a) cultivating the cell line with a basal carbon source repressing the promoter, b) cultivating the cell line with a limited amount of a supplemental carbon source de-repressing the promoter to induce production of the poi at a transcription rate or at least 15% as compared to the native pgap promoter, and c) producing and recovering the poi; and further an isolated regulatable promoter and a respective expression system.. . ... Lonza Inc

02/02/17 / #20170029827

Recombinant host cell engineered to overexpress helper proteins

The present invention is in the field of recombinant biotechnology, in particular in the field of protein expression. The invention generally relates to a method of expressing a protein of interest (poi) from a host cell. ... Lonza Inc








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