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Mallinckrodt Llc patents


Recent patent applications related to Mallinckrodt Llc. Mallinckrodt Llc is listed as an Agent/Assignee. Note: Mallinckrodt Llc may have other listings under different names/spellings. We're not affiliated with Mallinckrodt Llc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "M" | Mallinckrodt Llc-related inventors


Gallium-69 enriched target bodies

Gallium target bodies for producing germanium-68 are disclosed. The targets include an alloy of a base metal and gallium. ... Mallinckrodt Llc

Systems and methods for assaying an eluate of a radionuclide generator

A system for assaying an eluate includes a radiation detection device, a fluid handling system, and a connection interface. The radiation detection device includes a collection reservoir, and is adapted to measure a radioactive content of a sample within the collection reservoir. ... Mallinckrodt Llc

Systems and methods for electroplating sources for alpha spectroscopy

Disclosed herein are a system and method for electroplating an alpha emitting radionuclide, such as an actinide, for use in alpha spectroscopy. The electrodeposition system for electroplating an alpha emitting radionuclide can include an electroplating cell containing a solution of an electrolyte and the alpha emitting radionuclide, a metal target within the electroplating cell, and a metal anode at a distance from the metal target. ... Mallinckrodt Llc

Systems and methods for autoclave cart loading and unloading system

A system for manufacturing radionuclide generators including an enclosure defining a radioactive environment, at least one autoclave sterilizer within the enclosure, and at least two loading and unloading elevators. The enclosure includes radiation shielding to prevent radiation within the radioactive environment from moving to an exterior of the enclosure. ... Mallinckrodt Llc

Methods of reducing the risk of mortality associated with a medical treatment

Disclosed are methods of treatment that permit a reduction of risk of mortality in infants who are candidates for treatment with inhaled nitric oxide, by identifying a subset of such infants who are at an increased risk of mortality upon treatment with inhaled nitric oxide; also disclosed are related systems for use in administering inhaled nitric oxide and methods of distributing a pharmaceutical product.. . ... Mallinckrodt Llc

Devices and methods for engaging indexed valve and pressurized canister assembly with collar and for linear actuation by plunger assembly into fluid communication with device for regulating drug delivery

A valve assembly comprising a housing and a valve, the valve being disposed within the housing, a first indexed member integral to the housing, the first indexed member adapted to be complementary to a second indexed member, and a radio frequency identification device adapted to communicate with a radio frequency receiver, the valve being configured to align with a canister, seal the canister and open in a single movement. A drug containment device having said valve assembly is also disclosed.. ... Mallinckrodt Llc

Systems and methods for formulating radioactive liquids

Systems and methods for formulating a radioactive liquid using a disposable container are described. The disposable container includes a flexible sidewall defining an interior space for containing the radioactive liquid during formulation. ... Mallinckrodt Llc

Devices, methods, and systems for priming, separating, and collecting blood components

A photopheresis system (200) is disclosed, and that may be configured to execute one or more protocols. These protocols include: 1) protocols (400; 430; 460) for purging air out of a centrifuge bowl (210) used by the photopheresis system (200); 2) protocols (500; 510 550) for assessing the installation/operation of one or more pressure domes (330) used by the photopheresis system (200); and 3) protocols (580; 600; 660; 700; 740) for collecting buffy coat from blood processed by the photopheresis system (200).. ... Mallinckrodt Llc

Systems and methods for dispensing radioactive liquids

Systems and methods for dispensing radioactive liquids using a liquid dispensing apparatus are described. The apparatus includes a support arm rotatable about a rotation axis, an actuator operatively connected to the support arm and configured to at least one of rotate the support arm about the rotation axis and displace the support arm in a direction parallel to the rotation axis, and a pipette assembly mounted to the support arm. ... Mallinckrodt Llc

Purification process

A process for purifying mo-99 from an acidic solution obtained by dissolving an irradiated solid target comprising uranium in an acidic medium, or from an acidic solution comprising uranium and which has previously been irradiated in a nuclear reactor, or from an acidic solution comprising uranium and which has been used as reactor fuel in a homogeneous reactor, the process comprising contacting the acidic solution with an adsorbent comprising a zirconium oxide, zirconium hydroxide, zirconium alkoxide, zirconium halide and/or zirconium oxide halide, and eluting the mo-99 from the adsorbent using a solution of a strong base, the eluate then being subjected to a subsequent purification process involving an alkaline-based mo-99 chromatographic recovery step on an anion exchange material. Also provided is apparatus for carrying out the process.. ... Mallinckrodt Llc

Processes for generating germanium-68 with reduced volatiles

Processes for producing germanium-68 from a gallium target body are disclosed. In some embodiments, germanium-68 and gallium are precipitated to remove metal impurities. ... Mallinckrodt Llc

Cannula for minimizing dilution of dosing during nitric oxide delivery

Described are nasal cannulas that improve the precision of the delivered dose for nitric oxide therapy by reducing the dilution of nitric oxide. The nasal cannulas may reduce the total volume and potential for retrograde flow during nitric oxide therapy through the design of the specific dimensions of the flow path and/or having check valves in the nitric oxide delivery line and/or having a flapper or umbrella valve dedicated to nitric oxide delivery. ... Mallinckrodt Llc

Systems and methods for high humidity curing within tablet coating system

The disclosure encompasses systems and methods for performing high temperature and high humidity curing of tablets using air flow delivered from a recirculating air handler to a pan coater of a tablet coating device. The recirculating air handler may be integrated into a preexisting tablet coating device so that the air flow may be delivered by the preexisting air handler or by the recirculating air handler as desired.. ... Mallinckrodt Llc

Automated hepa filter integrity testing

Hepa filter integrity testing apparatus including an automated mover, a scan module connected to the automated mover, and scan probes disposed along the length of the scan module. Assemblies also include hepa filters and the filter integrity testing apparatus. ... Mallinckrodt Llc

02/01/18 / #20180028956

Hepa filter airflow distribution systems

An air distribution system for supplying filtered air to isolator working volumes includes an inlet including a hepa filter and an outlet including a slidably mounted sintered panel. Methods for supplying filtered air to an isolator working volume are also disclosed.. ... Mallinckrodt Llc

01/25/18 / #20180023555

Pump for operation in radioactive environment

A method of assembling a pump for use in a radioactive environment includes positioning tubing between a rotor and a clamp of the pump. The pump includes a pump head that includes a casing, the rotor, and the clamp. ... Mallinckrodt Llc

01/18/18 / #20180018490

Scanning system for scanning objects in radioactive environment

A system for manufacturing radionuclide generators includes an enclosure defining a radioactive environment. The enclosure includes radiation shielding to prevent radiation within the radioactive environment from moving to an exterior of the enclosure. ... Mallinckrodt Llc

01/18/18 / #20180015039

Combinational liposome compositions for cancer therapy

The present invention provides methods for delivery of therapeutic agents to a subject using multi-component liposomal systems. The methods include administration of a therapeutic liposome containing an active agent, followed by a administration of an attacking liposome that induces release of the agents from the therapeutic liposome.. ... Mallinckrodt Llc

01/11/18 / #20180008596

Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds

The present invention generally relates to processes for preparing highly pure morphinan-6-one products. The processes involve reducing the concentration of alpha, beta unsaturated ketone compounds present as impurities in morphinan 6 one products or reaction mixtures including morphinan 6 one compounds by treatment with a sulfur-containing compound.. ... Mallinckrodt Llc

01/11/18 / #20180008532

Immediate release, abuse deterrent pharmaceutical compositions

The present disclosure provides pharmaceutical compositions and processes for making solid dosage form pharmaceutical compositions that provide immediate release of active ingredients and have abuse deterrent properties. The pharmaceutical compositions provided herein comprise at least one pharmaceutically active ingredient, at least one low molecular weight hydrophilic polymer, at least one high molecular weight hydrophilic polymer, and an effervescent system.. ... Mallinckrodt Llc

12/07/17 / #20170348502

Apparatus and method for monitoring nitric oxide delivery

Described is an apparatus for monitoring nitic oxide delivery, wherein such apparatus comprises an indicator to inform a user of the apparatus when the flow of breathing gas rises above or falls below a predetermined level or range. Also described is a method of monitoring nitric oxide delivery, wherein the flow of breathing gas is measured and displayed. ... Mallinckrodt Llc

11/09/17 / #20170321244

Systems and methods for sterility testing of radionuclide generator column assemblies

A method includes sterilizing a column assembly including a column having a parent radionuclide contained therein with a sterilizer. The method further includes transferring the column assembly from the sterilizer to a first clean room environment, transferring the column assembly from the first clean room environment to a second clean room environment, and collecting a sterility test sample from the column assembly within the second clean room environment.. ... Mallinckrodt Llc

11/09/17 / #20170320673

Conveyance system for operation in radioactive environment

A system for manufacturing radionuclide generators includes an enclosure defining a radioactive environment. The enclosure includes radiation shielding to prevent radiation within the radioactive environment from moving to an exterior of the enclosure. ... Mallinckrodt Llc

11/09/17 / #20170319810

Apparatus and method for humidity conditioning sample gas of a patient breathing circuit affiliated with a ventilator and/or nitric oxide delivery system

A therapeutic gas is administered to a patient. A sample gas is drawn from the therapeutic gas supply, and passed through a water-permeable tubular membrane. ... Mallinckrodt Llc

11/09/17 / #20170319809

Apparatus and method for detecting liquid level in a clear or partially clear container

A trap bowl is provided to accumulate liquid droplets from a filter, as a liquid content. The trap bowl includes a transparent vertical prism. ... Mallinckrodt Llc

11/09/17 / #20170319778

Pump for operation in radioactive environment

A system for manufacturing radionuclide generators includes an enclosure defining a radioactive environment. The enclosure includes radiation shielding to prevent radiation within the radioactive environment from moving to an exterior of the enclosure. ... Mallinckrodt Llc

11/09/17 / #20170319728

Column assembly transfer mechanism and systems and methods for sanitizing same

A system includes a radiation containment chamber, an isolator connected to the radiation containment chamber, a rotating transfer door positioned between the radiation containment chamber and the isolator, and an antimicrobial vapor generator connected to the isolator. The rotating transfer door includes a cavity for receiving a radionuclide generator column assembly, and is rotatable between a first position, in which the cavity is open to the radiation containment chamber, and a second position, in which the cavity is open to the isolator. ... Mallinckrodt Llc

11/09/17 / #20170319724

Systems and methods for sterilizing sealed radionuclide generator column assemblies

Systems and methods for sterilizing a column assembly including a column having an interior containing a retaining media and a parent radionuclide retained by the retaining media, an inlet port in fluid communication with the interior of the column, and an outlet port in fluid communication with the interior of the column. The method includes sealing at least one of the inlet port and the outlet port to form a sealed column assembly such that fluid communication with the column interior though both the inlet port and the outlet port is prevented, and sterilizing the sealed column assembly to form a terminally-sterilized column assembly.. ... Mallinckrodt Llc

10/26/17 / #20170304483

Formulations for wound therapy

The present invention relates to novel formulations comprising a dry powder fibrin sealant comprised of a mixture of fibrinogen and/or thrombin, for use in the treatment of wounds or injuries, in particular for use as a topical hemostatic composition or for surgical intervention.. . ... Mallinckrodt Llc

10/05/17 / #20170281896

Apparatus and method for filtering liquid particles from inspiratory gas flow of a patient breathing circuit affiliated with a ventilator and/or nitric oxide delivery system

The present disclosure relates to a filter apparatus for filtering liquid from a gas, the apparatus having a first housing having a gas inlet and a gas outlet; a first filter media disposed in the first housing; a second filter media disposed in the housing; and a second housing forming a first collection basin disposed in the flow path between the first filter media and the second filter media, so that a path is defined for the gas flowing from the inlet, through the first filter media, past the collection basin, through the second filter media, and to the outlet. The present disclosure also relates to a method of passing a gas through a coalescing filter media and through a hydrophobic filter media.. ... Mallinckrodt Llc

10/05/17 / #20170281615

Extended release, abuse deterrent dosage forms

Extended release, abuse deterrent dosage forms comprising crush-resistant controlled-release particles that provide abuse deterrent properties to the dosage forms. The crush-resistant controlled-release particles, which comprise plastic/elastic polymers and at least one active pharmaceutical ingredient (api) or a pharmaceutically acceptable salt thereof, are prepared by a hot melt extrusion process.. ... Mallinckrodt Llc

09/21/17 / #20170266262

Fibrinogen preparations enriched in fibrinogen with an extended alpha chain

The present invention relates to fibrinogen preparations enriched in α-extended fibrinogen. Compositions comprising such preparations show improved clotting properties compared to preparations based on hmw fib which typically contain no or only low amounts of α-extended fibrinogen. ... Mallinckrodt Llc

08/17/17 / #20170232166

Use and monitoring of inhaled nitric oxide with left ventricular assist devices

Described are systems and methods for administration of nitric oxide (no) with use of left ventricular assists devices (lvads), as well as systems and methods for monitoring the no delivery devices and/or the lvad.. . ... Mallinckrodt Llc

08/10/17 / #20170224826

Glucomannan containing pharmaceutical compositions with extended release and abuse deterrent properties

A pharmaceutical composition comprising at least one active pharmaceutical ingredient (api) or a pharmaceutically acceptable salt thereof, a glucomannan, a first polyalkylene oxide having an average molecular weight of no more than 300,000, and a second polyalkylene oxide having an average molecular weight of at least 1,000,000 and methods of making. The pharmaceutical composition provides extended release of the api and has abuse deterrent features.. ... Mallinckrodt Llc

08/03/17 / #20170216551

Compensating for disruptions in breathing gas flow measurement

The present disclosure generally relates to systems and methods for delivery of therapeutic gas to patients, using techniques to compensate for disruptions in breathing gas flow measurement, such as when breathing gas flow measurement is unavailable or unreliable. Such techniques include using historical breathing gas flow rate data, such as moving average flow rates, moving median flow rates and/or flow waveforms. ... Mallinckrodt Llc

08/03/17 / #20170215411

Administration and monitoring of nitric oxide in ex vivo fluids

Described are systems and methods for monitoring administration of nitric oxide (no) to ex vivo fluids. Examples of such fluids include blood in extracorporeal membrane oxygenation (ecmo) circuits or perfusion fluids used for preserving ex vivo organs prior to transplanting in a recipient. ... Mallinckrodt Llc

07/27/17 / #20170209665

Therapeutic gas delivery device with pulsed and continuous flow control

Described are methods and devices for therapeutic or medical gas delivery that utilize at least one proportional control valve and at least one binary control valve. The proportional control valve may be in series with the binary control valve to provide a valve combination capable of pulsing therapeutic gas at different flow rates, depending on the setting of the proportional control valve. ... Mallinckrodt Llc

07/06/17 / #20170189538

Hemostatic microspheres

Provided herein are hemostatic compositions. In one embodiment, the hemostatic composition includes cross-linked polymer microspheres, such as cross-linked gelatin microspheres with pores. ... Mallinckrodt Llc

07/06/17 / #20170189537

Hemostatic microspheres

Provided herein are hemostatic compositions. In one embodiment, the hemostatic composition includes cross-linked polymer microspheres, such as cross-linked gelatin microspheres with pores. ... Mallinckrodt Llc

06/29/17 / #20170182033

Pharmaceutical compositions for extended release of oxycodone and acetaminophen resulting in a quick onset and prolonged period of analgesia

The present disclosure provides extended release pharmaceutical compositions comprising oxycodone and acetaminophen that produce a quick initial onset of analgesia, yet, maintain analgesia for about 12 hours after administration of the composition to a subject in need thereof. The pharmaceutical compositions disclosed herein also reduce the levels of acetaminophen in a subject's blood near the end of the dosing interval because the acetaminophen released by the pharmaceutical composition is being eliminated by a subject's body faster than it is being absorbed.. ... Mallinckrodt Llc

06/08/17 / #20170157071

Reduced dose intravenous acetaminophen

Described herein are compositions and methods for intravenous administration of acetaminophen at a single dose level of less than about 1000 mg for the treatment or prevention of pain (e.g., postoperative pain) and/or fever.. . ... Mallinckrodt Llc

06/01/17 / #20170152148

Method and apparatus for the manufacture of high purity carbon monoxide

Method and apparatus of making 99.99% pure gaseous carbon monoxide comprising the steps of degassing liquid formic acid producing degassed liquid formic acid; reacting the degassed liquid formic acid or a degassed gaseous formic acid with a liquid mineral acid at an elevated temperature producing a gas phase comprising carbon monoxide gas and water vapor and a liquid phase; condensing the gas phase producing liquid water and gaseous carbon monoxide; scrubbing the carbon monoxide gas producing a gaseous 99.99% pure carbon monoxide having a purity of at least 99.99%, and, compressing the gaseous 99.99% pure carbon monoxide producing the 99.99% pure gaseous carbon monoxide, wherein the method is performed at least in the substantial absence of metallic nickel, metallic iron, nickel-containing alloys, and, iron-containing alloys from contacting any of the liquids or gases, wherein the fe(co)5 content is less than 1 ppb, wherein the ni(co)4 content is less than 10 ppb, wherein the water moisture content is less than 5 ppm, and, wherein the co2 content is less than 2 ppm. Gaseous carbon monoxide purities of 99.998% and 99.999% are achieved by removing residual air from the gaseous carbon monoxide.. ... Mallinckrodt Llc

05/11/17 / #20170128694

Breathing apparatus detection and purging

Described are methods for safer nitric oxide delivery, as well as apparatuses for performing these methods. The methods may include detecting the presence or absence of a nasal cannula, and stopping the delivery of nitric oxide or providing an alert if the cannula is disconnected. ... Mallinckrodt Llc

05/11/17 / #20170128690

Cannula for minimizing dilution of dosing during nitric oxide delivery

The present invention generally relates to, amongst other things, systems, devices, materials, and methods that can improve the accuracy and/or precision of nitric oxide therapy by, for example, reducing the dilution of inhaled nitric oxide (no). As described herein, no dilution can occur because of various factors. ... Mallinckrodt Llc

04/06/17 / #20170095633

Device and method for diffusing high concentration no with inhalation therapy gas

Systems and methods of the present invention can enable high concentration no to be delivered into ventilator breathing circuits, via a diffusing device, without generating undesirably large amounts of no2.. . ... Mallinckrodt Llc

04/06/17 / #20170095470

Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia

The present disclosure provides an extended release pharmaceutical composition comprising hydrocodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof.. ... Mallinckrodt Llc

03/23/17 / #20170080393

Slurry dispenser for radioisotope production

A slurry dispensing system is disclosed. A peristaltic pump may direct a flow of slurry out of a horizontal mixer to a slurry dispenser. ... Mallinckrodt Llc

03/16/17 / #20170074845

Systems and methods for compensating long term sensitivity drift of electrochemical gas sensors exposed to nitric oxide

Described are systems and methods for compensating long term sensitivity drift of catalytic type electrochemical gas sensors used in systems for delivering therapeutic nitric oxide (no) gas to a patient by compensating for drift that may be specific to the sensors atypical use in systems for delivering therapeutic nitric oxide gas to a patient. In at least some instances, the long term sensitivity drift of catalytic type electrochemical gas sensors can be addressed using calibration schedules, which can factor in the absolute change in set dose of no being delivered to the patient that can drive one or more baseline calibrations. ... Mallinckrodt Llc

03/16/17 / #20170074844

Systems and methods for compensating long term sensitivity drift of electrochemical gas sensors exposed to nitric oxide

Described are systems and methods for compensating long term sensitivity drift of catalytic type electrochemical gas sensors used in systems for delivering therapeutic nitric oxide (no) gas to a patient by compensating for drift that may be specific to the sensors atypical use in systems for delivering therapeutic nitric oxide gas to a patient. In at least some instances, the long term sensitivity drift of catalytic type electrochemical gas sensors can be addressed using calibration schedules, which can factor in the absolute change in set dose of no being delivered to the patient that can drive one or more baseline calibrations. ... Mallinckrodt Llc

03/16/17 / #20170072157

Systems and methods for compensating long term sensitivity drift of electrochemical gas sensors exposed to nitric oxide

Described are systems and methods for compensating long term sensitivity drift of catalytic type electrochemical gas sensors used in systems for delivering therapeutic nitric oxide (no) gas to a patient by compensating for drift that may be specific to the sensors atypical use in systems for delivering therapeutic nitric oxide gas to a patient. In at least some instances, the long term sensitivity drift of catalytic type electrochemical gas sensors can be addressed using calibration schedules, which can factor in the absolute change in set dose of no being delivered to the patient that can drive one or more baseline calibrations. ... Mallinckrodt Llc

03/16/17 / #20170072153

Systems and methods for compensating long term sensitivity drift of electrochemical gas sensors exposed to nitric oxide

Described are systems and methods for compensating long term sensitivity drift of catalytic type electrochemical gas sensors used in systems for delivering therapeutic nitric oxide (no) gas to a patient by compensating for drift that may be specific to the sensors atypical use in systems for delivering therapeutic nitric oxide gas to a patient. In at least some instances, the long term sensitivity drift of catalytic type electrochemical gas sensors can be addressed using calibration schedules, which can factor in the absolute change in set dose of no being delivered to the patient that can drive one or more baseline calibrations. ... Mallinckrodt Llc

02/09/17 / #20170037108

Recombinant fibrinogen

The present invention relates to nucleotide sequences encoding a fibrinogen alpha, beta or gamma chain. The sequences are optimized for expression in a eukaryotic cell culture system. ... Mallinckrodt Llc

02/02/17 / #20170029432

(+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof

The present invention provides (+)-morphinans comprising toll-like receptor 9 (tlr9) antagonist activity, as well as methods for using the (+)-morphinans to treat pain. Also provided are pharmaceutical combination compositions comprising a (+)-morphinan and an opioid agonist/monoamine reuptake inhibitor, as well as methods for using the combination compositions to treat pain.. ... Mallinckrodt Llc

01/26/17 / #20170021124

Systems and methods for compensating long term sensitivity drift of electrochemical gas sensors exposed to nitric oxide

Described are systems and methods for compensating long term sensitivity drift of catalytic type electrochemical gas sensors used in systems for delivering therapeutic nitric oxide (no) gas to a patient by compensating for drift that may be specific to the sensors atypical use in systems for delivering therapeutic nitric oxide gas to a patient. In at least some instances, the long term sensitivity drift of catalytic type electrochemical gas sensors can be addressed using calibration schedules, which can factor in the absolute change in set dose of no being delivered to the patient that can drive one or more baseline calibrations. ... Mallinckrodt Llc

01/19/17 / #20170014592

Systems and methods for compensating long term sensitivity drift of electrochemical gas sensors exposed to nitric oxide

Described are systems and methods for compensating long term sensitivity drift of catalytic type electrochemical gas sensors used in systems for delivering therapeutic nitric oxide (no) gas to a patient by compensating for drift that may be specific to the sensors atypical use in systems for delivering therapeutic nitric oxide gas to a patient. In at least some instances, the long term sensitivity drift of catalytic type electrochemical gas sensors can be addressed using calibration schedules, which can factor in the absolute change in set dose of no being delivered to the patient that can drive one or more baseline calibrations. ... Mallinckrodt Llc

01/19/17 / #20170014591

Systems and methods for compensating long term sensitivity drift of electrochemical gas sensors exposed to nitric oxide

Described are systems and methods for compensating long term sensitivity drift of catalytic type electrochemical gas sensors used in systems for delivering therapeutic nitric oxide (no) gas to a patient by compensating for drift that may be specific to the sensors atypical use in systems for delivering therapeutic nitric oxide gas to a patient. In at least some instances, the long term sensitivity drift of catalytic type electrochemical gas sensors can be addressed using calibration schedules, which can factor in the absolute change in set dose of no being delivered to the patient that can drive one or more baseline calibrations. ... Mallinckrodt Llc

01/12/17 / #20170008832

Two-step process for preparing 3-substituted phenylalkylamines

Processes for preparing 3-substituted phenylalkylamines comprising reacting a phenyl boronic compound with an α-β unsaturated carbonyl-containing compound via an asymmetric 1,4-addition reaction, followed by reductive alkylation. The processes may be useful in the synthesis of tapentadol.. ... Mallinckrodt Llc








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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