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Massachusetts Eye And Ear Infirmary patents


Recent patent applications related to Massachusetts Eye And Ear Infirmary. Massachusetts Eye And Ear Infirmary is listed as an Agent/Assignee. Note: Massachusetts Eye And Ear Infirmary may have other listings under different names/spellings. We're not affiliated with Massachusetts Eye And Ear Infirmary, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "M" | Massachusetts Eye And Ear Infirmary-related inventors


Drug delivery system and methods of use

A drug delivery system (dds) including a hydrophobic porous scaffold and a hydrogel having a hydrophilic polymer and one or more biologic drugs provides sustained zero-order release of the one or more biologic drugs. Also provided herein are methods of making and using a dds including a hydrophobic porous scaffold and a hydrogel having a hydrophilic polymer and one or more biologic drugs.. ... Massachusetts Eye And Ear Infirmary

Calculating conjunctival redness

The present application includes methods, systems and computer readable storage devices for determining a color score for at least a portion of a biological tissue. The subject matter of the application is embodied in a method that includes obtaining a digital image of the biological tissue, and receiving a selection of a portion of the image as an evaluation area. ... Massachusetts Eye And Ear Infirmary

Molecular imaging methods for diagnosis and evaluation of ocular and systemic diseases

This invention relates generally to minimally-invasive, in vivo methods of detecting one or more ligands on an intraluminal surface of a blood vessel using microparticles coated with one or more ligand binding partners. More particularly, in certain embodiments, the invention relates to minimally-invasive, in vivo methods of detecting endothelial and leukocyte antigens that are predictive of diabetic retinopathy (dr) and/or other conditions using protein-conjugated microparticles detectable by a non-invasive detection system, for example, a scanning laser ophthalmoscope. ... Massachusetts Eye And Ear Infirmary

Cyp450 lipid metabolites reduce inflammation and angiogenesis

Methods for reducing angiogenesis, inflammation, and vascular permeability in a subject by administering an epoxymetabolite of docosahexaenoic acid (dha) and eicosapentaenoic acid (epa), e.g., as listed in table a, e.g., one or both of 17,18-epoxyeicosatetraenoic acid (eeq) and 19,20-epoxydocosapentaenoic acid (edp), e.g., for the treatment of conditions associated with inflammation or excess angiogenesis or neovascularization, including age-related macular degeneration, cancer, stroke, and arthritis.. . ... Massachusetts Eye And Ear Infirmary

Methods of delivering an agent to the eye

Methods of delivering agents to structures within the eye are provided.. . ... Massachusetts Eye And Ear Infirmary

Prosthetic devices for semicircular canal defects

This disclosure features elongated prosthetic devices that can be used to repair, e.g., resurface or occlude, a defect of a semicircular canal, e.g., a superior semicircular canal dehiscence, as wellmethods of making and using these devices. For example, the devices can be made using three-dimensional (3d) printing.. ... Massachusetts Eye And Ear Infirmary

Gene augmentation therapies for inherited retinal degeneration caused by mutations in the prpf31 gene

The present invention relates to methods and compositions for gene therapy of retinitis pigmentosa related to mutations in pre-mrna processing factor 31 (prpf31).. . ... Massachusetts Eye And Ear Infirmary

Methods for treating ocular inflammatory disorders

Provided are methods for treating ocular inflammatory disorders, including macular edema, using an amp kinase activator, e.g., 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (aicar). The method reduces inflammation, thereby minimizing the loss of vision or visual function associated with these ocular disorders.. ... Massachusetts Eye And Ear Infirmary

Methods and compositions for preserving the viability of photoreceptor cells

Provided are methods and compositions for maintaining the viability of photoreceptor cells following retinal detachment. The viability of photoreceptor cells can be preserved by administering an apoptosis inhibitor to a mammal having an eye with retinal detachment. ... Massachusetts Eye And Ear Infirmary

Methotrexate for proliferative vitreoretinopathy

The use of methotrexate, e.g., repeated dosing or sustained-release formulations of methotrexate, for treating or reducing risk of proliferative vitreoretinopathy (pvr) or epiretinal membranes (erm), e.g., after surgical vitrectomy to treat retinal detachment.. . ... Massachusetts Eye And Ear Infirmary

Treatment of ocular disorders

The invention includes a method of treating an intraocular disorder in a mammal, the method comprising administering to the mammal a very late antigen-4 (vla-4) antagonist for the treatment of selected ocular disorders.. . ... Massachusetts Eye And Ear Infirmary

Treatment of rhinosinusitis with p-glycoprotein inhibitors

Provided herein are, inter alia, methods for treating rhinosinusitis with p-glycoprotein inhibitors. A subject having rhinosinusitis is identified and then treated by administration to the subject an effective amount of a p-gp inhibitor. ... Massachusetts Eye And Ear Infirmary

Efficient delivery of therapeutic molecules in vitro and in vivo

Compositions are described for direct protein delivery into multiple cell types in the mammalian inner ear. The compositions are used to deliver protein(s) (such as gene editing factors) editing of genetic mutations associated with deafness or associated disorders thereof. ... Massachusetts Eye And Ear Infirmary

Efficient delivery of therapeutic molecules to cells of the inner ear

Compositions and provided to induce cells of the inner ear to renter the cell cycle and to proliferate. In particular, hair cells are induced to proliferate by administration of a composition which activates the myc and notch. ... Massachusetts Eye And Ear Infirmary

11/16/17 / #20170326254

Efficient delivery of therapeutic molecules in vitro and in vivo

A chimeric molecule of one or more proteins or peptides fused, complexed or linked to one or more anionic molecules. Efficient in vitro and in vivo delivery is attained by encapsulating these molecules in cationic lipids or cationic liposomes. ... Massachusetts Eye And Ear Infirmary

08/31/17 / #20170247672

Method for efficient delivery of therapeutic molecules in vitro and in vivo

Compositions are described for direct protein delivery into multiple cell types in the mammalian inner ear. The compositions are used to deliver protein(s) (such as gene editing factors) editing of genetic mutations associated with deafness or associated disorders thereof. ... Massachusetts Eye And Ear Infirmary

08/03/17 / #20170216393

Methods and compositions for preserving photoreceptor and retinal pigment epithelial cells

Provided are methods and compositions for maintaining the viability of photoreceptor cells and/or retinal pigment epithelial cells in a subject with an ocular disorder including, for example, age-related macular degeneration (amd) (e.g., dry or neovascular amd), retinitis pigmentosa (rp), or a retinal detachment. The viability of the photoreceptor cells and/or the retinal pigment epithelial cells can be preserved by administering a necrosis inhibitor either alone or in combination with an apoptosis inhibitor to a subject having an eye with the ocular condition. ... Massachusetts Eye And Ear Infirmary

08/03/17 / #20170216294

Methotrexate for proliferative vitreoretinopathy

The use of methotrexate, e.g., repeated dosing or sustained-release formulations of methotrexate, for treating or reducing risk of proliferative vitreoretinopathy (pvr) or epiretinal membranes (erm), e.g., after surgical vitrectomy to treat retinal detachment.. . ... Massachusetts Eye And Ear Infirmary

07/13/17 / #20170196806

Methods and compositions for preserving the viability of photoreceptor cells

Provided are methods and compositions for maintaining the viability of photoreceptor cells following retinal detachment. The viability of photoreceptor cells can be preserved by administering a neuroprotective agent, for example, a substance capable of suppressing endogenous mcp-1, a mcp-1 antagonist, a substance capable of suppressing endogenous tnf-alpha, a tnf-alpha antagonist, a substance capable of suppressing endogenous il-1 beta, an il-1 beta antagonist, a substance capable of inducing endogenous bfgf, exogenous bfgf, a bfgf mimetic, and combinations thereof, to a mammal having an eye with retinal detachment. ... Massachusetts Eye And Ear Infirmary

07/06/17 / #20170188814

Inflammatory eye disorders

Provided herein are methods of evaluating efficacy of a treatment in a subject having eye inflammation (e.g., a subject having dry eye syndrome) and selecting a subject for participation in a clinical study. Also provided are methods of treating a subject having eye inflammation (e.g., a subject having dry eye syndrome).. ... Massachusetts Eye And Ear Infirmary

02/16/17 / #20170043015

Methods for cross-linking corneal collagen with verteporfin for the treatment of disorders of the eye

Described are compositions and methods of using verteporfin-based photodynamic therapy (pdt) to increase the biomechanical strength of the cornea. More particularly, described herein are compositions and methods for cross-linking collagen in corneal tissue which are useful in the treatment of corneal ectatic disorders.. ... Massachusetts Eye And Ear Infirmary

02/09/17 / #20170035883

Methods and compositions for treating conditions of the eye

Provided are methods and compositions for treating ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example neovascular age-related macular degeneration. The selectivity and sensitivity of, for example, a photodynamic therapy (pdt)based approach can be enhanced by combining the pdt with an anti-fasl factor, for example, an anti-fasl neutralizing antibody.. ... Massachusetts Eye And Ear Infirmary

01/26/17 / #20170020909

Methods of treating glaucoma using amp-activated protein kinase (ampk) activators

Methods of reducing intraocular pressure in a mammal using ampk activators, e.g., for treating glaucoma.. . ... Massachusetts Eye And Ear Infirmary








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