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Massachusetts Institute Of Technology patents


Recent patent applications related to Massachusetts Institute Of Technology. Massachusetts Institute Of Technology is listed as an Agent/Assignee. Note: Massachusetts Institute Of Technology may have other listings under different names/spellings. We're not affiliated with Massachusetts Institute Of Technology, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "M" | Massachusetts Institute Of Technology-related inventors


Method for dynamic video magnification

The method for dynamic video magnification magnifies small motions occurring simultaneously within large motions. The method involves selecting a region of interest from a video for magnification. ... Massachusetts Institute Of Technology

On-demand high-capacity ride-sharing via dynamic trip-vehicle assignment with future requests

Described is a method and system for vehicle routing and request assignment which incorporates a prediction of future demand. The method seamlessly integrates sampled future requests into request assignments and vehicle routing.. ... Massachusetts Institute Of Technology

Extending footprint for localization using surface penetrating radar (spr)

A method for extending a surface penetrating radar (spr) footprint for performing localization with an spr system is disclosed. The method may include may include transmitting at least one spr signal from at least one spr transmit element. ... Massachusetts Institute Of Technology

Dynamic resonant circuits for chemical and physical sensing with a reader and rfid tags

A tag for detecting an analyte can include a radio frequency identification tag including a sensor portion, the sensor portion configured to change resistivity when the radio frequency identification tag contacts or interacts with an analyte, whereby the resistivity change alters an output of the radio frequency identification tag, wherein the sensor portion includes a circuit, and wherein the sensor portion is configured to activate the circuit or deactivate the circuit when contacted or having interacted with the analyte, where the sensor portion includes a plurality of carbon nanotubes associated with a chemically-degradable polymer. In certain embodiments, the chemically degradable polymer can be a metallo-supramolecular polymer.. ... Massachusetts Institute Of Technology

Methods and products related to glutaminase inhibitors

The invention relates to methods and related compositions for enhancing cancer therapy and in particular glutaminase inhibitor therapy. The methods involve methods for identifying patients susceptible to glutaminase inhibitor therapy as well as sensitizing patients to glutaminase inhibitor therapy.. ... Massachusetts Institute Of Technology

Method and system for localization of a vehicle using surface penetrating radar

A method and a surface penetrating radar (spr) system for localization of a vehicle are disclosed. The method includes transmitting a radar signal having a first frequency into a subsurface region adjacent to a vehicle. ... Massachusetts Institute Of Technology

Determining surface characteristics

A method for determining surface characteristics is disclosed. The method may include transmitting a surface penetrating radar (spr) signal towards a surface from a spr system. ... Massachusetts Institute Of Technology

Systems and methods for genome mapping

A system for molecular mapping includes a semiconductor substrate defining a reservoir to receive a sample of molecules and a nanofluidic channel in fluid communication with the reservoir. The system also includes a plurality of electrodes, in electrical communication with the nanofluidic channel, to electrophoretically trap the sample of molecules in the nanofluidic channel. ... Massachusetts Institute Of Technology

Multiplexed signal amplified fish via splinted ligation amplification and sequencing

The present invention relates to a method for amplifying at least one target rna in a fixed and, optionally, expanded biological sample. In an embodiment of the invention, the method comprises incubating the fixed biological sample with a pair of polynucleotides complementary to non-overlapping and proximal sequences of a target rna, wherein the polynucleotide pair hybridizes to the target rna; ligating the polynucleotide pair using a ligase; and amplifying the ligation product. ... Massachusetts Institute Of Technology

Articles and methods providing scale-phobic surfaces

This invention relates generally to articles, devices, and methods for inhibiting or preventing the formation of scale during various industrial processes. In certain embodiments, a vessel is provided for use in an industrial process, the vessel including a surface in contact with a mineral solution, wherein the surface is provided or is modified to have γpolar/γtotal no greater than about 0.2 and/or the surface is provided or is modified to have a surface energy γ no greater than about 32 mj/m2, thereby providing resistance to mineral scale deposits thereupon.. ... Massachusetts Institute Of Technology

Secure network coding for multi-description wireless transmission

Described herein is a method and system for wireless data transmission with network coding which limits encryption operations to a critical set of network coding coefficients in combination with multi-resolution and/or multi-description video coding. Such a method and system achieves hierarchical fidelity levels, robustness against wireless packet loss and efficient security by exploiting the algebraic structure of network coding.. ... Massachusetts Institute Of Technology

Surface modified diamond materials and methods of manufacturing

New compositions of matter and device constructs are disclosed in the form of diamond material layers or films having one or more surfaces treated with chemically active radicals, e.g., photo-radical or thermal-radical generators to reduce and stabilize their surface resistance. The compositions exhibit stable, markedly lower surface resistances, e.g., below about 3 kΩ sq−1 or between about 3 and 2 kΩ sq−1 or below 2 kΩ sq−1, or below 1 kΩ sq−1, or lower. ... Massachusetts Institute Of Technology

Use of microparticle additives to simultaneously enable artifact-free image registration, auto-focusing, and chromatic aberration correction in microscopy

High-contrast, high-density cell-sized microparticles are introduced into a cell-containing solution prior to the solution being spread onto a planar substrate for imaging. The microparticles facilitate both the process of imager autofocusing and the subsequent registration of multiple images taken of regions of the substrate. ... Massachusetts Institute Of Technology

Polymerizable sulfonamide compounds and polymers thereof

Methods, compositions, reagents, and systems that allow for the preparation and utilization of sulfonamide salt polymer electrolytes are disclosed herein. Methods and reagents to prepare sulfonamide salt monomers are also disclosed herein. ... Massachusetts Institute Of Technology

07/26/18 / #20180208699

Polymers and uses thereof

The present invention provides polymers and methods of preparing the same. In certain embodiments, the polymers comprise acrylate repeating units that have been derivatized (e.g., reduced and/or substituted) to form new polymeric structures. ... Massachusetts Institute Of Technology

07/26/18 / #20180206586

Energy harvesting footwear

The present disclosure is related to energy-harvesting articles of footwear, and associated components and methods. In some embodiments, an energy-harvesting article of footwear comprises a compressible bladder, a pneumatic motor fluidically connected to the compressible bladder, and an electric generator operatively coupled to the pneumatic motor. ... Massachusetts Institute Of Technology

07/19/18 / #20180205020

Emissive compounds and related devices

In one aspect, compositions comprising emissive compounds including polycyclic aromatic groups are provided. In some embodiments, the emissive compounds may include various moieties having desirable physical and electronic properties. ... Massachusetts Institute Of Technology

07/19/18 / #20180204379

System and method for providing reconstruction of human surfaces from orientation data

A system and method for reconstructing a positional contour of a variably contoured surface includes a plurality of positional sensors and a plurality of orientation sensor disposed upon the surface, a processor and a memory. The system captures a positional description of the surface and produces a rotationally-invariant point cloud, and captures a first absolute orientation description of the surface and produces a first set of relative orientations. ... Massachusetts Institute Of Technology

07/19/18 / #20180202935

Multifocal imaging systems and method

In the systems and methods of the present invention a multifocal multiphoton imaging system has a signal to noise ratio (snr) that is reduced by over an order of magnitude at imaging depth equal to twice the mean free path scattering length of the specimen. An mmm system based on an area detector such as a multianode photomultiplier tube (mapmt) that is optimized for high-speed tissue imaging. ... Massachusetts Institute Of Technology

07/19/18 / #20180202375

Optimized fuel management system for direct injection ethanol enhancement of gasoline engines

Fuel management system for enhanced operation of a spark ignition gasoline engine. Injectors inject an anti-knock agent such as ethanol directly into a cylinder. ... Massachusetts Institute Of Technology

07/19/18 / #20180201889

Delivery of materials to anucleate cells

The current subject matter includes methods, systems, articles, and techniques to deliver material to anucleate cells, such as red blood cells. Using a rapid deformation based microfluidic system, loading of red blood cells with macromolecules of different sizes has been shown. ... Massachusetts Institute Of Technology

07/12/18 / #20180198256

Method for high-concentration doping of germanium with phosphorous

In a method for electrically doping a semiconducting material, a layer of germanium is formed having a germanium layer thickness, while in situ incorporating phosphorus dopant atoms at a concentration of at least about 5×1018 cm−3 through the thickness of the germanium layer during formation of the germanium layer. Additional phosphorus dopant atoms are ex situ incorporated through the thickness of the germanium layer, after formation of the germanium layer, to produce through the germanium layer thickness a total phosphorus dopant concentration of at least about 2×1019 cm−3.. ... Massachusetts Institute Of Technology

07/12/18 / #20180197999

High-linearity transistors

A transistor includes a first gate-controlled region having a first threshold voltage and a second gate-controlled region in parallel with the first gate-controlled region. The second gate-controlled region has a second threshold voltage different form the first threshold voltage.. ... Massachusetts Institute Of Technology

07/12/18 / #20180197736

Systems and methods for graphene based layer transfer

A graphene-based layer transfer (gblt) technique is disclosed. In this approach, a device layer including a iii-v semiconductor, si, ge, iii-n semiconductor, sic, sige, or ii-vi semiconductor is fabricated on a graphene layer, which in turn is disposed on a substrate. ... Massachusetts Institute Of Technology

07/12/18 / #20180197686

Lubricant-impregnated surfaces for electrochemical applications, and devices and systems using the same

In certain embodiments, the invention relates to an electrochemical device having a liquid lubricant impregnated surface. At least a portion of the interior surface of the electrochemical device includes a portion that includes a plurality of solid features disposed therein. ... Massachusetts Institute Of Technology

07/12/18 / #20180196058

Multiplexed detection with isotope-coded reporters

Some aspects of this invention provide reagents and methods for the sensitive, quantitative and simultaneous detection of target analytes in complex biological samples by liquid chromatography tandem mass spectrometry (lc ms/ms). Some aspects of this invention provide affinity reagents encoded with mass reporters for the sensitive and quantitative translation of an analyte of interest into a mass tag. ... Massachusetts Institute Of Technology

07/12/18 / #20180196025

Chemical sensor for heavy metal detection

A chemical sensor for heavy metal detection is provided. The chemical sensor includes an inlet, a chamber in fluid communication with the inlet, and an outlet in fluid communication with the chamber. ... Massachusetts Institute Of Technology

07/12/18 / #20180195213

Active woven materials

Active fabrics typically include a plurality of fibers. At least one of the fibers exhibits a change in length or width upon exposure to an external stimulus, such as heat, moisture, or light. ... Massachusetts Institute Of Technology

07/12/18 / #20180194106

Active lattices

An active lattice capable of self-transforming responsive to a stimulus, such as heat or moisture, includes a plurality of links interconnected to each other at a plurality of nodes. At least a subset of links includes at least two materials that have different coefficients of expansion in response to an external stimulus. ... Massachusetts Institute Of Technology

07/12/18 / #20180194066

Systems and methods of machine vision assisted additive fabrication

The present application relates generally to systems and methods for using machine vision to provide information on one or more aspects of an additive fabrication device, such as calibration parameters and/or an object formed by the device or in the process of being formed by the device. According to some aspects, a method is provided for calibrating an additive fabrication device. ... Massachusetts Institute Of Technology

07/12/18 / #20180193518

Controllably degradable compositions and methods

Methods, compositions, kits, and drug delivery devices are provided for treating, adhering, or sealing biological tissues. The methods include combining a first solution that includes an oligomer/polymer component and a second solution that includes a dendrimer component, and at least one of the oligomer/polymer component and dendrimer component includes at least one substituent that is capable of photoreversible dimerization. ... Massachusetts Institute Of Technology

07/12/18 / #20180192974

Integrated optical blocking filter for compact x-ray imaging detector

An x-ray imaging device can include an x-ray detector and an optical-blocking filter. The x-ray detector has an entrance-window surface for receiving x-rays, at least one side surface, and a back surface facing in an opposite direction from the entrance-window surface. ... Massachusetts Institute Of Technology

07/05/18 / #20180190973

Systems and methods of preparing lithium sulfur electrode using sacrificial template

Embodiments described herein relate generally to lithium sulfur batteries and methods of producing the same. As described herein, preventing coarsening of sulfur during the well-known melt-diffusion processing of cathodes allows a high areal capacity of 10.7 mah/cm2 at current density of 3.4 ma/cm2 (c-rate of 1/5 h−1). ... Massachusetts Institute Of Technology

07/05/18 / #20180188151

Method to distinguish and analyze white blood cells in the presence of red blood cells

Method for distinguishing between red blood cells and white blood cells. The method includes obliquely illuminating the blood sample with light from at least two rotational angles and analyzing light side scattered from cells in the sample to provide accurate discrimination of white blood cell types based on the anisotropy of red blood cell side scatter as compared to more isotropic white blood cell side scatter.. ... Massachusetts Institute Of Technology

07/05/18 / #20180187186

Compositions comprising nucleic acids and methods of using the same

The disclosure relates to compositions comprising and methods for chemical modification of single guide rna (sgrna), tracrrna and/or crrna used individually or in combination with one another or cas system components. Compositions comprising modified ribonucleic acids have been designed with chemical modification for even higher efficiency as unmodified native strand of sgrna. ... Massachusetts Institute Of Technology

07/05/18 / #20180187183

Dna microscopy

The present invention relates to dna microscopy methods to record the cellular co-localization and/or spatial distributions of arbitrary nucleic acid sequences, or other biomolecules tagged with nucleic sequences. The method involves sequence-components which may identify the targeted sequences-of-interest themselves and/or spatial beacons relative to which their distances are measured.. ... Massachusetts Institute Of Technology

07/05/18 / #20180187169

Thiolase variants and methods of use thereof

Described herein are thiolase variants, cells expressing the thiolase variants, and methods of their use for the biosynthesis of desired products.. . ... Massachusetts Institute Of Technology

07/05/18 / #20180187072

Ligands for semiconductor nanocrysals

In this invention, polyimidazole ligands (pils) incorporating pendant imidazole moieties for nanocrystal binding and either sulfonatebetaine, carboxybetaine, or phosphocholinebetaine moieties for water-solubilization have been developed. Greatly enhanced stability of nanocrystals (both over time and in wide ph range) was achieved by incorporating multi-dentate imidazole moieties which provide strong coordination of the ligand to the nanocrystal surface and prevent aggregation of nanocrystals. ... Massachusetts Institute Of Technology

07/05/18 / #20180185513

Nano-fibular nanoparticle polymer-drug conjugate for sustained dermal delivery of retinoids

Disclosed herein are conjugated polymers comprising a polymer and an all-trans retinoic acid (atra) prodrug covalently bound to the polymer by a hydrolysable linker l or a pharmaceutically acceptable salt thereof, and methods of using same to treat certain disorders. In an embodiment, the conjugated polymer comprises poly (vinyl alcohol) covalently bound to atra through an ester linkage.. ... Massachusetts Institute Of Technology

07/05/18 / #20180185473

Lipid vesicle compositions and methods of use

The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.. ... Massachusetts Institute Of Technology

07/05/18 / #20180185286

Porous materials containing compounds including pharmaceutically active species

Materials containing pharmaceutically active species in solid (e.g., crystal) form, and related methods, are provided, allowing for improved stability, solubility, bioavailability, and/or dissolution rates for pharmaceutically active species having poor aqueous solubility.. . ... Massachusetts Institute Of Technology

06/28/18 / #20180184024

Methods and apparatus for true high dynamic range (thdr) time-delay-and-integrate (tdi) imaging

In time-delay-and-integrate (tdi) imaging, a charge-couple device (ccd) integrates and transfers charge across its columns. Unfortunately, the limited well depth of the ccd limits the dynamic range of the resulting image. ... Massachusetts Institute Of Technology

06/28/18 / #20180181540

Systems and methods for distributed solution of optimization problems

A framework is presented for designing a class of distributed, asynchronous optimization algorithms realized as signal processing architectures utilizing various conservation principles. The architectures are specifically based on stationary conditions pertaining to primal and dual variables in a class of generally nonconvex optimization problems. ... Massachusetts Institute Of Technology

06/28/18 / #20180180811

Waveguide formation using cmos fabrication techniques

Conventional approaches to integrating waveguides within standard electronic processes typically involve using a dielectric layer, such as polysilicon, single-crystalline silicon, or silicon nitride, within the in-foundry process or depositing and patterning a dielectric layer in the backend as a post-foundry process. In the present approach, the back-end of the silicon handle is etched away after in-foundry processing to expose voids or trenches defined using standard in-foundry processing (e.g., complementary metal-oxide-semiconductor (cmos) processing). ... Massachusetts Institute Of Technology

06/28/18 / #20180180364

Liquid-impregnated surfaces, methods of making, and devices incorporating the same

The invention is directed to an article with a liquid-impregnated surface, the surface having a matrix of features thereupon, spaced sufficiently close to stably contain a liquid therebetween or therewithin, and preferable also a thin film thereupon. The surface provides the article with advantageous non-wetting properties. ... Massachusetts Institute Of Technology

06/21/18 / #20180175809

Power amplifier operation

Systems and methods for improving power amplifier operation are provided. A system may include a baseband signal generator communicatively coupled to a baseband signal digital-to-analog converter. ... Massachusetts Institute Of Technology

06/21/18 / #20180175635

Wireless power transfer

A method includes determining, by a base station including a number of transmitting coils, a first number of mutual magnetic parameters, each mutual magnetic parameter being associated with one of the transmitting coils and a receiving coil of at least one receiving coil associated with at least one electronic device remotely located from and to be remotely charged by the base station, determining a plurality of control signals based on the first number of mutual magnetic parameters, each control signal being associated with a corresponding one of the transmitting coils, providing each control signal to a driving circuit coupled to the control signal's corresponding transmitting coil, and using each control signal to cause the driving circuit coupled to the control signal's corresponding transmitting coil to cause a current with a magnitude and phase determined from the control signal to flow in the corresponding transmitting coil.. . ... Massachusetts Institute Of Technology

06/21/18 / #20180174291

Determining soil state and controlling equipment based on captured images

Methods and systems for controlling earth moving equipment are described. In some embodiments, a stream of images may be captured using at least one imaging system. ... Massachusetts Institute Of Technology

06/21/18 / #20180172723

Apparatus and methods for photonic integrated resonant accelerometers

The accelerometers disclosed herein provide excellent sensitivity, long-term stability, and low swap-c through a combination of photonic integrated circuit technology with standard micro-electromechanical systems (mems) technology. Examples of these accelerometers use optical transduction to improve the scale factor of traditional mems resonant accelerometers by accurately measuring the resonant frequencies of very small (e.g., about 1 μm) tethers attached to a large (e.g., about 1 mm) proof mass. ... Massachusetts Institute Of Technology

06/21/18 / #20180171604

Sorption-based atmospheric water harvesting device

A water-harvesting system can operate with a material that can take up and release water with minimum energy requirements and powered by low-grade energy sources, such as sunlight, in order to potentially allow its deployment into households, especially those located in sunny regions. A water-harvesting method and system can include vapor adsorption using a porous metal-organic framework. ... Massachusetts Institute Of Technology

06/21/18 / #20180171297

Targeting bcl11a enhancer functional regions for fetal hemoglobin reinduction

Provided herein are nucleic acid molecules that target the bcl11a enhancer functional regions, compositions comprising the nucleic acid molecules and methods for increasing fetal hemoglobin levels in a cell by disrupting bcl11a expression at the genomic level. Also provided herein are methods and compositions relating to the treatment of hemoglobinopathies by reinduction of fetal hemoglobin levels. ... Massachusetts Institute Of Technology

06/21/18 / #20180169953

Adaptive material deposition for additive manufacturing

A closed-loop adaptive material deposition apparatus and method uses a scanning system to monitor an additively manufactured object as it is being fabricated and adapting the geometric shape and material composition of the subsequent layers based on the scan data. The scanning system repeatedly captures geometric and/or material information of a partially manufactured object with optional auxiliary objects inserted during the manufacturing process. ... Massachusetts Institute Of Technology

06/21/18 / #20180169302

Methods and compositions for the treatment of open and closed wound spinal cord injuries

Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. ... Massachusetts Institute Of Technology

06/21/18 / #20180168440

Methods and apparatus for imaging and 3d shape reconstruction

An otoscope may project a temporal sequence of phase-shifted fringe patterns onto an eardrum, while a camera in the otoscope captures images. A computer may calculate a global component of these images. ... Massachusetts Institute Of Technology

06/14/18 / #20180166727

Extruder feed system

Extruder feed system. The system includes a pair of spaced-apart, internally and oppositely threaded rotatable elements for receiving and engaging a plastic filament material. ... Massachusetts Institute Of Technology

06/14/18 / #20180164440

Methods and apparatus for three-dimensional (3d) imaging

A method of imaging a scene includes estimating multiple three-dimensional (3d) representations, each of which corresponds to a respective portion of the scene. Neighboring portions of the scene area are at least partially overlapping. ... Massachusetts Institute Of Technology

06/14/18 / #20180163995

Selective solar absorbers with tuned oxygen deficiency and methods of fabrication thereof

Systems and methods disclosed herein are directed towards the fabrication of a solar absorber comprising an ir reflector layer deposited on a substrate; a first cermet layer deposited in contact with the ir reflector layer; a second cermet layer deposited in contact with the first cermet layer; a first anti-reflection coating layer deposited in contact with the second cermet layer; a second anti-reflection coating layer deposited in contact with the first anti-reflection coating layer. A sputtering process may be used to deposit some or all of the layers, and the ysz layers in each cermet layer may be deposited with a tuned partial oxygen pressure in order to form a layer that is oxygen-deficient.. ... Massachusetts Institute Of Technology

06/14/18 / #20180163265

Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing

The invention provides for systems, methods, compositions, and kits for the complete characterization of targeted nuclease specificity which necessitates techniques that can assess the full possibility space of off-target activity and genomic stability following genome editing. Also provided are the materials and techniques which enable the comprehensive genomic stability accompanying a range of cellular perturbations, including genome editing (zfn, talen, crispr, and future technologies) and disease modeling among other applications.. ... Massachusetts Institute Of Technology

06/14/18 / #20180163216

Gene expression in bacteroides

Provided herein, in some aspects, are tools (e.g., methods, compositions and nucleic acids) for building genetic circuits in bacteroides and parabacteroides bacteria, as well as the bacteria containing the genetic circuits.. . ... Massachusetts Institute Of Technology

06/14/18 / #20180162087

Flexural digital material construction and transduction

Flexural digital materials are discrete parts that can be assembled into a lattice structure to produce an actuatable structure capable of coordinated reversible spatially-distributed deformation. The structure comprises a set of discrete flexural digital material units assembled according to a lattice geometry, with a majority of the discrete units being connected, or adapted to be connected, to at least two other units according to the geometry. ... Massachusetts Institute Of Technology

06/14/18 / #20180161836

Articles and methods for modifying condensation on surfaces

The articles and methods described herein provide a way to manipulate condensation on a surface by micro/nano-engineering textures on the surface and filling the spaces between the texture features with an impregnating liquid that is stably held therebetween or therewithin. The articles and methods allow droplets of water, or other condensed phases, even in micrometer size range, to easily shed from the surface, thereby enhancing contact between a condensing species and the condensing surface. ... Massachusetts Institute Of Technology

06/14/18 / #20180161727

Concentration control in filtration systems, and associated methods

Concentration control in filtration systems and associated methods are generally described. Streams originating from upstream filters and having similar concentrations of a target minor component and/or similar osmotic pressures can be mixed and subsequently filtered within additional filters. ... Massachusetts Institute Of Technology

06/14/18 / #20180161362

Controllably degradable compositions and methods

Methods for treating, adhering, or sealing biological tissue are provided. The methods include combining solutions containing a polymer component and a dendrimer component capable of reacting with each other, and at least one of the components includes a substituent capable of photoreversible dimerization that can be reversibly dimerized. ... Massachusetts Institute Of Technology

06/14/18 / #20180161180

Passive artificial knee

A passive artificial knee includes a knee hinge assembly defining a knee axis, a locking hinge assembly defining a locking axis, and a post linking the knee hinge assembly and the locking hinge assembly. A ground reaction force applied to the artificial knee posterior to the locking axis causes an interfering relation by compression of the locking hinge assembly and the knee hinge assembly during heel strike at early-stance gait phase of an individual wearing the artificial knee, thereby locking rotation of the post about the knee axis. ... Massachusetts Institute Of Technology

06/07/18 / #20180160217

Systems, apparatus, and methods for hearing protection

Systems, apparatus, and methods for filtering acoustic energy include a first conduit substantially aligned with a longitudinal axis and defining a first opening for receiving incident acoustic energy from the environment. A cavity in fluid communication with the first conduit selectively amplifies and/or dampens the acoustic energy based on an associated resonance frequency. ... Massachusetts Institute Of Technology

06/07/18 / #20180159181

Flame-retardant, non-toxic phosphate ester ionic liquid electrolytes and method of making

A phosphate ester compound can include a cation and an anion, the anion being an alkyl phosphate. The phosphate ester compound can be a phosphate ester ionic liquid. ... Massachusetts Institute Of Technology

06/07/18 / #20180159012

Systems and methods for the synthesis of high thermoelectric performance doped-snte materials

A thermoelectric composition comprising tin (sn), tellurium (te) and at least one dopant that comprises a peak dimensionless figure of merit (zt) of 1.1 and a seebeck coefficient of at least 50 μv/k and a method of manufacturing the thermoelectric composition. A plurality of components are disposed in a ball-milling vessel, wherein the plurality of components comprise tin (sn), tellurium (te), and at least one dopant such as indium (in). ... Massachusetts Institute Of Technology

06/07/18 / #20180155721

Synthetic bacteriophages and bacteriophage compositions

Disclosed herein are novel synthetic bacteriophages and bacteriophage compositions, methods of production thereof, and therapeutic uses thereof.. . ... Massachusetts Institute Of Technology

06/07/18 / #20180155400

Compressed pathways for nonribosomal molecular biosynthesis

Provided herein are synthetic pathways from escherichia coli and vibrio cholerae genes for the production of new, synthetic nonribosomal peptides, and methods and compositions comprising the same. Some aspects of the present disclosure are directed to modified bacterial cells comprising a compressed biosynthetic pathway that comprises (a) biosynthetic genes obtained from one species encoding enzymes active in the bioassembly of a nonribosomal molecule, (b) biosynthetic genes obtained from another species encoding enzymes active in the bioassembly of a nonribosomal molecule that is different from the nonribosomal molecule of (a). ... Massachusetts Institute Of Technology

06/07/18 / #20180155283

Dopamine d2 receptor ligands

The present invention relates to novel dopamine d2 receptor ligands. The invention further relates to functionally-biased dopamine d2 receptor ligands and the use of these compounds for treating or preventing central nervous system and systemic disorders associated with dysregulation of dopammode inergic activity. ... Massachusetts Institute Of Technology

06/07/18 / #20180154627

Methods and apparatus for hygromorphic shape control

A composite film includes a substrate that is not responsive to relative humidity, and also one or more layers of hygromorphic material. The hygromorphic material expands in response to an increase in relative humidity and contracts in response to a decrease in relative humidity. ... Massachusetts Institute Of Technology

06/07/18 / #20180154170

Methods and compositions for treating mental disorders and conditions

The invention, in some aspects, relates to methods to alter activity in cells and the use of such method to treat disorders and conditions. The methods involve, in part, expressing stimulus-activated opsin polypeptides in neurons involved in memory and behavior and activating the opsin polypeptides to modulate activity of cells in which they are expressed and/or cells to which the cells that express the opsin polypeptides project.. ... Massachusetts Institute Of Technology

05/31/18 / #20180149639

Modeling neural network dysfunction

The present invention relates to in vitro models of autism and methods of using the same to diagnose disorders associated with network dysfunction, e.g., autism schizophrenia, depression, obsessive-compulsive spectrum disorders, bipolar disorder, or epilepsy, and to identify compounds for use in treating these conditions.. . ... Massachusetts Institute Of Technology

05/31/18 / #20180148729

Engineered bacteria for production and release of therapeutics

Some embodiments described herein relate to cells which have been genetically engineered to release a polypeptide when a population of the cells reaches a desired density. In some embodiments, the released polypeptide may be a therapeutic polypeptide. ... Massachusetts Institute Of Technology

05/31/18 / #20180148364

Methods and apparatus for additive manufacturing of glass

In illustrative implementations of this invention, a crucible kiln heats glass such that the glass becomes or remains molten. A nozzle extrudes the molten glass while one or more actuators actuate movements of the nozzle, a build platform or both. ... Massachusetts Institute Of Technology

05/31/18 / #20180148065

Clutchless shifting of a manual transmission

An apparatus including a drive shaft, a transmission, and a motor shaft. The drive shaft includes a drive gear and is configured to transmit power to a wheel of a vehicle. ... Massachusetts Institute Of Technology

05/31/18 / #20180147826

Methods and apparatus for additive manufacturing with molten glass

A nozzle deposits a filament of viscous, molten glass onto a print bed, while the print bed rotates about a vertical axis and translates in x, y, and z directions. The deposition is computer controlled, such that the resulting deposited filament forms a desired glass object that is solid after it anneals. ... Massachusetts Institute Of Technology

05/31/18 / #20180147798

Methods for fabricating low cost 3-d printed parts with expanded material properties

A 3-d (three dimensional) printing system is provided that includes a customized matrix having suitable material properties and geometric patterning to facilitate filling and retention of one or more filler material. The customized matrix defines the geometry and shape of the object. ... Massachusetts Institute Of Technology

05/24/18 / #20180145110

Distributed nanowire sensor for single photon imaging

An integrated, superconducting imaging sensor may be formed from a single, meandering nanowire. The sensor is capable of single-photon (or single-event) detection and imaging with ˜10 micron spatial resolution and sub-100-picosecond temporal resolution. ... Massachusetts Institute Of Technology

05/24/18 / #20180143295

System and technique for mitigation of clutter in radar

Described are a system and technique to mitigate the impacts of clutter in a radar system. The system and technique require only linear co-polarized measurements can be incorporated into the standard radar signal processing chain without slowing down radar performance.. ... Massachusetts Institute Of Technology

05/24/18 / #20180143125

Device and method for analysing and controlling cell motility

The invention is related to a device and method for analysing and controlling cell motility. In accordance with an aspect of the present invention, there if provided a microfluidic device for analyzing and controlling the motility of a cell, the device comprising: (a) a first inlet for introducing a cell sample; (b) an outlet for discharging the cell sample; (c) a microfluidic channel in fluid communication with and intermediate the first inlet and outlet; (d) a first pump coupled to the first inlet for pumping the cell sample in the microfluidic channel; and (d) an observation area within a portion of the microfluidic channel for analysing and controlling the motility of the cell, wherein the first pump generates a shear stress in the observation area, the shear stress generates a shearotactical signal for driving movement of the cell.. ... Massachusetts Institute Of Technology

05/24/18 / #20180141832

Ion concentration polarization-electrocoagulation hybrid water treatment system

Between two juxtaposed similar ion exchange membranes (aems or cems), an ion depletion zone and ion enrichment zone are generated under an electric field. As cations are selectively transferred through the cems, for example, anions are relocated in order to achieve electro-neutrality, resulting in the concentration drop (increase) in ion depletion (enrichment) zone. ... Massachusetts Institute Of Technology

05/24/18 / #20180141274

Multimaterial 3d-printing with functional fiber

In a method for printing a three dimensional structure, a continuous length of fiber that includes, interior to a surface of the fiber, a plurality of different materials arranged as an in-fiber functional domain, with at least two electrical conductors disposed in the functional domain in electrical contact with at least one functional domain material, is dispensed through a single heated nozzle. After sections of the length of fiber are dispensed from the heated nozzle, the sections are fused together in an arrangement of a three dimensional structure. ... Massachusetts Institute Of Technology

05/24/18 / #20180140625

Production of stable non-polyadenylated rnas

The invention relates in aspects to hybrid rnas lacking a poly-a tail and nucleic acid vectors for expressing the rna. The hybrid rnas in some instances have a stabilizing triple helical structure. ... Massachusetts Institute Of Technology

05/24/18 / #20180140233

High fidelity systems, apparatus, and methods for collecting noise exposure data

Systems, apparatus, and methods for collecting, interpreting, and utilizing noise exposure data may include sensors to obtain an analog signal representative of impulse noise sound pressure and an analog signal representative of continuous noise sound pressure. At least one adc may generate digital signals by sampling the analog signals at rates equal to or greater than twice the reciprocal of a minimum impulse noise rise time. ... Massachusetts Institute Of Technology

05/24/18 / #20180140172

Apparatus, systems, and methods for biomedical imaging and stimulation

A multi-channel optical imaging and stimulation system includes a light source to deliver light beams into a light guide. Different light beams are coupled into different spatial modes supported by the light guide. ... Massachusetts Institute Of Technology

05/17/18 / #20180138751

Wireless non-radiative energy transfer

Described herein are embodiments of a source high-q resonator, optionally coupled to an energy source, a second high-q resonator, optionally coupled to an energy drain that may be located a distance from the source resonator. A third high-q resonator, optionally coupled to an energy drain that may be located a distance from the source resonator. ... Massachusetts Institute Of Technology

05/17/18 / #20180136210

Liquid biopsy detection of leukemia using closed-loop microfluidics

This invention describes a one-step technique for the simultaneous label-free detection and concentration of blast cells from a blood sample. Enrichment of blast cells is achieved using a closed loop microfluidics system, allowing continuous removal of waste and non-target cells to generate concentrated samples of high purity without the need for specific targeting of proteins by antibodies. ... Massachusetts Institute Of Technology

05/17/18 / #20180135970

Systems, apparatus, and methods for spectral imaging

A spectral imaging system includes an autocorrelator to generate different autocorrelations when the moving reflector in the autocorrelator is at different positions so as to reconstruct spectral images. The system also includes a position measurement system to measure the actual positions of the moving reflector when autocorrelations are taken. ... Massachusetts Institute Of Technology

05/17/18 / #20180134945

Nanoparticle-based shear-thickening materials

Compositions including an aqueous colloidal dispersion of a nanomaterial and methods for preparing and using the same are described. The nanomaterial includes, disposed on a surface of the nanomaterial, a first coupling agent including silane and a functional group including an amino acid, and a second coupling agent including silane and a polymer with a molecular weight between 1,000 and 20,000.. ... Massachusetts Institute Of Technology

05/17/18 / #20180133693

Biotemplated perovskite nanomaterials

A biotemplated nanomaterial can include a crystalline perovskite.. . ... Massachusetts Institute Of Technology

05/17/18 / #20180133343

Nanoparticle conjugates and uses thereof

The targeted delivery of therapeutic agents to specific cells remains a challenge in drug delivery. Provided herein are nanoparticle-targeting agent conjugates that can be used for the targeted delivery of therapeutic agents to certain cells and target tissues. ... Massachusetts Institute Of Technology

05/10/18 / #20180131851

Methods and apparatus for optical fiber imaging

An open-ended, incoherent bundle of optical fibers transmits light from a nearby scene. A camera captures images of the back end of the fiber bundle. ... Massachusetts Institute Of Technology

05/10/18 / #20180131720

Dynamic flow system

System and methods for communicating across a network comprise: a database containing high level security rules for the network; computing devices communicating on the network; a security rule translation module; event sensors configured to monitor and detect one or more events occurring on or relating to the network, and in response thereto, provide to the security rule translation module an indication of occurrence for each of the one or more security events. The security rule translation module may associate the security rules with the security events corresponding to the received indication, and produce a low-level security rule based on data from the high-level security rule and the received indication of occurrence of the security events. ... Massachusetts Institute Of Technology

05/10/18 / #20180131311

Highly-efficient near-field thermophotovoltaics using surface-polariton emitters and thin-film photovoltaic-cell absorbers

A near-field thermophotovoltaic system comprises a hot emitter and a cold absorbing photovoltaic cell separated by a small gap. The emitter emits hot photons and includes a polaritonic material that supports a surface-polaritonic mode. ... Massachusetts Institute Of Technology

05/10/18 / #20180128850

Integrated resonant accelerometer using optical strain sensor

An accelerometer may comprise a proof mass, a first tether mechanically coupled to the side of the proof mass and to an anchor, and a ring resonator integrated with the tether to form a sensing tether. The ring resonator and the tether may be configured such that a strain sustained by the sensing tether causes a change of a resonance condition of the ring resonator. ... Massachusetts Institute Of Technology

05/10/18 / #20180128723

Particle isolation/enrichment using continuous closed-loop micro-fluidics

The present invention encompasses a micro-fluidic system having a closed-loop configuration in which inertial micro-fluidic separation of particles and/or cells is continuously repeated by feeding part of the output back to the input so that the purity and/or concentration of the particles and/or cell is maximized. The invention also includes methods of using the micro-fluidic system.. ... Massachusetts Institute Of Technology

05/10/18 / #20180127759

Dynamic genome engineering

Provided herein, in some embodiments, are genomic editing constructs that can achieve nearly 100% recombination efficiency within a select population of bacterial cells.. . ... Massachusetts Institute Of Technology

05/10/18 / #20180127745

Cell sorting

The invention provides for use of crispr-cas systems to sort barcoded cells or molecules. Cells or nucleic acid molecules may be sorted from a heterogenous population by targeting a barcode of interest specific for a cell or cell progeny or nucleic acid molecule of interest.. ... Massachusetts Institute Of Technology

05/10/18 / #20180127447

Metathesis catalysts and methods thereof

The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and/or stereoselectivity. ... Massachusetts Institute Of Technology

05/10/18 / #20180126677

Extremely compliant yet tough hydrogel systems as ultrasound transmission agents

A method for making a tough and compliant hydrogel. A precursor hydrogel is made of a first polymer selected to maintain high elasticity and a second polymer selected to dissipate mechanical energy. ... Massachusetts Institute Of Technology

05/10/18 / #20180126367

Light-assisted photocatalyst regeneration and oxygen-resilient radical polymerization

A photocatalyst can be regenerated with increasing efficiency, turnover number and turnover frequency in the presence of air by irradiating the photocatalyst with a first range of wavelengths of light that excite the photocatalyst to an intermediate and irradiating the intermediate with a second range of wavelengths of light that turns the intermediate to the photocatalyst.. . ... Massachusetts Institute Of Technology

05/10/18 / #20180126080

Bi-directional motion of a lorentz-force actuated needle-free injector (nfi)

The present invention relate to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber of a plurality of chambers. ... Massachusetts Institute Of Technology

05/10/18 / #20180125391

Systems, apparatus, and methods related to modeling, monitoring, and/or managing metabolism

Systems, apparatus, and methods related to modeling, monitoring, and/or managing metabolism of a subject include measuring a respiratory quotient (rq) level in a subject and/or optimizing and executing a nonlinear feedback model to model energy substrate utilization in the subject based on at least one of a macronutrient composition and caloric value of food consumed by the subject, an intensity and duration of activity by the subject, a rate and maximum capacity of glycogen storage in the subject, a rate and maximum capacity of de novo lipogenesis in the subject, a quality and duration of sleep by the subject, and/or an rq level in the subject.. . ... Massachusetts Institute Of Technology

05/03/18 / #20180123724

Scheduled light path switching in optical networks and automatic assessment of traffic impairments that would result from adding or deleting a channel in a wavelength-division multiplexed optical communication network

. . A single-wavelength light path is selected between a source access node and a destination access node of a wavelength-division multiplexed optical network, including selecting an illuminated wavelength of the light path and selecting a start time and duration for a data transfer that would not interfere with other data transfers. If no start time/wavelength combination is available with duration sufficient to transport the data, an additional wavelength is automatically selected, based on modeling, that would not impair traffic being carried by other wavelengths in the network, and without a time-consuming manual process of the prior art. ... Massachusetts Institute Of Technology

05/03/18 / #20180123238

Multipolarized vector sensor array antenna system for search and rescue applications

The present disclosure is directed towards direction finding (df) systems that can detect and locals a radio frequency (rf) signal (e.g. An emergency beacon) is two dimensions (i.e., azimuth and elevation). ... Massachusetts Institute Of Technology

05/03/18 / #20180119219

Augmenting in situ nucleic acid sequencing of expanded biological samples with in vitro sequence information

The invention provides in situ nucleic acid sequencing to be conducted in biological specimens that have been physically expanded. The invention leverages the techniques for expansion microscopy (exm) to provide new methods for in situ sequencing of nucleic acids in a process referred to herein as “expansion sequencing” (exseq).. ... Massachusetts Institute Of Technology

05/03/18 / #20180119141

Crispr/cas global regulator screening platform

Provided herein are methods for identifying genetic networks and methods of treating neurodegenerative disorders associated with α-synuclein dysfunction.. . ... Massachusetts Institute Of Technology

05/03/18 / #20180119089

Microbial system for biosynthesis of natural and engineered products coupled to in situ extraction in supercritical co2

Provided herein are methods of producing a bioproduct by culturing a cell in a multiphase reactor that comprises supercritical co2, near critical co2, or liquid co2.. . ... Massachusetts Institute Of Technology

05/03/18 / #20180118806

Engineered replacement of partial variant water soluble membrane proteins

The present invention is directed to water-soluble membrane proteins, methods for the preparation thereof and methods of use thereof.. . ... Massachusetts Institute Of Technology

05/03/18 / #20180116504

Apparatus and method of determining an eye prescription

Eye prescriptions may be determined by providing a simple, easy to use, portable device with a specially configured targeting light source that aligns the eye, mitigates accommodation, and provides accurate results. Unlike stationary, closed view autorefractors, this device typically is portable, self-usable, relatively inexpensive, enabling more widespread use across the world.. ... Massachusetts Institute Of Technology

04/19/18 / #20180107909

Chemical and physical sensing with a reader and rfid tags

A method of detecting a stimulus can include detecting an output from a radio frequency identification tag including a sensor. A smartphone-based sensing strategy can use chemiresponsive nanomaterials integrated into the circuitry of commercial near field communication tags to achieve non-line-of-sight, portable, and inexpensive detection and discrimination of gas phase chemicals (e.g., ammonia, hydrogen peroxide, cyclohexanone, and water) at part-per-thousand and part-per-million concentrations.. ... Massachusetts Institute Of Technology

04/19/18 / #20180106936

Methods and apparatus for imaging using optical cavity

In illustrative implementations, an imaging system may comprise a lens, an optical cavity and a time-of-flight camera. The imaging system may capture an image of a scene. ... Massachusetts Institute Of Technology

04/19/18 / #20180105806

Method for rna-guided endonuclease-based dna assembly

The invention provides a novel approach to facilitate assembly of dna molecules. This approach utilizes rna-guided endonucleases, capable of targeting any dna sequence, which cleave dna and generate dna fragments characterized by single stranded overhangs. ... Massachusetts Institute Of Technology

04/19/18 / #20180104690

Reaction circuit design in microfluidic circuits

The microfluidic devices and systems disclosed herein reduce sample loss and help decrease sample processing bottlenecks for applications such as next generation sequencing (ngs). The microfluidic devices include a plurality of reaction modules. ... Massachusetts Institute Of Technology

04/12/18 / #20180102644

Coupled split path power conversion architecture

. . Described herein are power conversion systems and related techniques which utilize a coupled split path (csp) circuit architecture. The csp structure combines switches, capacitors and magnetic elements in such a way that power is processed in multiple coupled split paths in a variety of voltage domains. ... Massachusetts Institute Of Technology

04/12/18 / #20180102470

Cryogenic electronic packages and assemblies

A cryogenic electronic package includes a circuitized substrate, an interposer, a superconducting multichip module (smcm) and at least one superconducting semiconductor structure. The at least one superconducting semiconductor structure is disposed over and coupled to the smcm, and the interposer is disposed between the smcm and the substrate. ... Massachusetts Institute Of Technology

04/12/18 / #20180102469

Cryogenic electronic packages and methods for fabricating cryogenic electronic packages

A cryogenic electronic package includes a first superconducting multi-chip module (smcm), a superconducting interposer, a second smcm and a superconducting semiconductor structure. The interposer is disposed over and coupled to the first smcm, the second smcm is disposed over and coupled to the interposer, and the superconducting semiconductor structure is disposed over and coupled to the second smcm. ... Massachusetts Institute Of Technology

04/12/18 / #20180100817

Stable nanocrystalline ordering alloy systems and methods of identifying same

Provided in one embodiment is a method of identifying a stable phase of an ordering binary alloy system comprising a solute element and a solvent element, the method comprising: determining at least three thermodynamic parameters associated with grain boundary segregation, phase separation, and intermetallic compound formation of the ordering binary alloy system; and identifying the stable phase of the ordering binary alloy system based on the first thermodynamic parameter, the second thermodynamic parameter and the third thermodynamic parameter by comparing the first thermodynamic parameter, the second thermodynamic parameter and the third thermodynamic parameter with a predetermined set of respective thermodynamic parameters to identify the stable phase; wherein the stable phase is one of a stable nanocrystalline phase, a metastable nanocrystalline phase, and a non-nanocrystalline phase.. . ... Massachusetts Institute Of Technology

04/05/18 / #20180096482

Devices for refractive field visualization

An apparatus according to an embodiment of the present invention enables measurement and visualization of a refractive field such as a fluid. An embodiment device obtains video captured by a video camera with an imaging plane. ... Massachusetts Institute Of Technology

04/05/18 / #20180095481

Variable thermal resistance

Electrical and electromechanical devices often require maintaining a specific temperature, or a narrow range or temperatures, during operation. An assembly regulates the temperature of a device by providing a variable thermal resistance between the device and a heatsink. ... Massachusetts Institute Of Technology

04/05/18 / #20180094927

Method and apparatus for reducing sensor power dissipation

A sensor produces the sensor data for a sensor data consumer. A facility receives a sensor profile of the sensor indicating a relationship between a sensor parameter operating range and a deviation of the sensor data as a result of scaling one or more sensor parameters. ... Massachusetts Institute Of Technology

04/05/18 / #20180094099

Bottlebrush copolymers and uses thereof

Materials (e.g., particles, hydrogels) that provide extended release of one or more therapeutic agents are useful platforms for drug delivery. In part, the present invention relates to new triblock (abc) bottlebrush copolymers which can be used in the formulation of particles and hydrogels for the extended release of therapeutic agents. ... Massachusetts Institute Of Technology

04/05/18 / #20180093229

Segregation resistant perovskite oxides with surface modification

A method and a composition to stabilize the surface cation chemistry of the perovskite or related oxides, and thus, to minimize or completely avoid the detrimental segregation and phase separation of dopant cations at the surface can include modifying the surface with more oxidizable metal cations and/or more oxidizable metal oxides, thereby reducing the oxygen vacancy concentration at the very surface.. . ... Massachusetts Institute Of Technology

04/05/18 / #20180092538

Systems and methods for dual-mode imaging using optical coherence tomography and fluorescence imaging

Systems and methods are provided to obtain optical coherence tomography data and fluorescence imaging data from an object. The systems and methods use a single light source to illuminate and excite fluorescence in the object and a common optical path including an optical fiber to provide illumination and excitation light and collect reflected and emitted light at the object. ... Massachusetts Institute Of Technology

03/29/18 / #20180090852

Stacked patch antenna array with castellated substrate

Described is a printed circuit antenna array including at least one castellated substrate. Also described is a stacked patch antenna array having at least one castellated substrate.. ... Massachusetts Institute Of Technology

03/29/18 / #20180090283

High-performance supercapacitors based on metal nanowire yarns

An energy-storage device is formed from a first and a second yarn, each yarn including a plurality of nanowires including aluminum and/or a transition metal. An anode pad is in contact with the first yarn and a cathode pad is in contact with the second yarn. ... Massachusetts Institute Of Technology

03/29/18 / #20180086641

Controlled-orientation films and nanocomposites including nanotubes or other nanostructures

Generally, the present invention provides methods for the production of materials comprising a plurality of nanostructures such as nanotubes (e.g., carbon nanotubes) and related articles. The plurality of nanostructures may be provided such that their long axes are substantially aligned and, in some cases, continuous from end to end of the sample. ... Massachusetts Institute Of Technology

03/29/18 / #20180085359

Use of chelators of divalent cations to promote nerve regeneration

Disclosed herein are methods to promote axonal outgrowth of a neuron comprising, contacting the neuron with an effective amount of a chelating agent, to thereby promote axonal outgrowth in the neuron. Also disclosed are methods of treating a subject for a cns lesion, comprising, administering to the subject a therapeutically effective amount of a chelating agent, also disclosed are devices for promoting regeneration in a lesioned neuron, and pharmaceutical compositions comprising a therapeutically effective amount of a chelating agent formulated for localized administration directly to an injured neuron. ... Massachusetts Institute Of Technology

03/22/18 / #20180080927

Systems including janus droplets

Embodiments described herein may be useful in the detection of analytes. The systems and methods may allow for a relatively simple and rapid way for detecting analytes such as chemical and/or biological analytes and may be useful in numerous applications including sensing, food manufacturing, medical diagnostics, performance materials, dynamic lenses, water monitoring, environmental monitoring, detection of proteins, detection of dna, among other applications. ... Massachusetts Institute Of Technology

03/22/18 / #20180080019

Encoding of dna vector identity via iterative hybridization detection of a barcode transcript

Embodiments disclosed herein are directed to a new genetic perturbation and screening method that combines advantages of pooled perturbation with imaging assays for complex phenotypes. Specifically, the method may be used to screen pooled genomic perturbations to identify phenotypes and to identify perturbed genes at the single-cell level using optical barcodes. ... Massachusetts Institute Of Technology

03/22/18 / #20180079786

Constructs for continuous monitoring of live cells

Embodiments disclosed herein provide nucleic acid constructs and methods of use thereof that induce a live cell to give off sub-samples of the cell's cytosolic content. The term “cell” as used herein may be any cell type. ... Massachusetts Institute Of Technology

03/22/18 / #20180079125

Automatic process control of additive manufacturing device

Automatic process control of additive manufacturing. The system includes an additive manufacturing device for making an object and a local network computer controlling the device. ... Massachusetts Institute Of Technology

03/22/18 / #20180078936

Systems, devices, and methods for microfluidics using modular blocks

The present disclosure is directed to the creation and/or manipulation of microfluidic systems and methods that can be formed in pre-existing modular blocks. Microfluidic paths can be formed in one or more blocks, and when multiple blocks are used, the blocks can be used together to form a path across the blocks. ... Massachusetts Institute Of Technology

03/22/18 / #20180078657

Amphiphilic nanoparticles for delivery of crispr based therapy

Disclosed are copolymer micelles for simultaneous delivery of cas9 mrna and guide rna for cas9 crispr gene editing. Also disclosed are copolymer micelles for simultaneous delivery of a therapeutic or diagnostic nucleic acid and a cross-linking or alkylating anticancer agent.. ... Massachusetts Institute Of Technology

03/22/18 / #20180078609

Methods and compositions for treating alzheimer's disease and other memory-associated disorders and conditions

The invention, in part, relates to the use of optogenetic methods to increase dendritic spine density on dg memory engram cells in treatment methods for memory-impairment-associated diseases and conditions.. . ... Massachusetts Institute Of Technology

03/22/18 / #20180078159

Cardiovascular assist system that quantifies heart function and faciltates heart recovery

The systems, devices, and methods presented herein use a heart pump to obtain measurements of cardiovascular function. The heart pumps described herein can operate in parallel with and unload the heart. ... Massachusetts Institute Of Technology

03/15/18 / #20180076003

Method and apparatus for a porous electrospray emitter

An ionic liquid ion source can include a microfabricated body including a base and a tip. The body can be formed of a porous material compatible with at least one of an ionic liquid or room-temperature molten salt. ... Massachusetts Institute Of Technology

03/15/18 / #20180074457

Near-to-eye and see-through holographic displays

A holographic display is comprised of space-multiplexed elemental modulators, each of which consists of a surface acoustic wave transducer atop an anisotropic waveguide. Each “line” of the overall display consists of a single anisotropic waveguide across the display's length with multiple surface acoustic wave transducers spaced along the waveguide length, although for larger displays, the waveguide may be divided into segments, each provided with separate illumination. ... Massachusetts Institute Of Technology

03/15/18 / #20180074383

Electroactive polymer membrane-based active lens assemblies

Active lens assemblies based on a deformable lens adhered to an electroactive polymer (eap) membrane based actuator, active lens systems comprising such active lenses, and methods of actuating a deformable lens are described. The active lenses can provide controllable optical power, withstand constant periods of actuation, have low power consumption, have fewer mechanically moving parts, have fast response times and/or high portability. ... Massachusetts Institute Of Technology

03/15/18 / #20180073031

Transcriptional sensor for bile acids in bacteroides thetaiotaomicron

The present disclosure relates, in some aspects, to bile acid sensors.. . ... Massachusetts Institute Of Technology

03/15/18 / #20180072895

Apparatus and methods employing liquid-impregnated surfaces

In certain embodiments, the invention is directed to apparatus comprising a liquid-impregnated surface, said surface comprising an impregnating liquid and a matrix of solid features spaced sufficiently close to stably contain the impregnating liquid therebetween or therewithin, and methods thereof. In some embodiments, one or both of the following holds: (i) 0<φ≦0.25, where φ is a representative fraction of the projected surface area of the liquid-impregnated surface corresponding to non-submerged solid at equilibrium; and (ii) sow(a)<0, where sow(a) is spreading coefficient, defined as γwa−γwo−γoa, where γ is the interfacial tension between the two phases designated by subscripts w, a, and o, where w is water, a is air, and o is the impregnating liquid.. ... Massachusetts Institute Of Technology

03/15/18 / #20180072327

Systems and methods for using an attention buffer to improve resource allocation management

Systems and methods for assessing resource allocation are provided. In some exemplary embodiments, the system uses an attention buffer to classify glances by a person and/or automated system, the buffer determining the impact the glances have on the person and/or automated system's situation awareness level. ... Massachusetts Institute Of Technology

03/15/18 / #20180071738

Massively parallel on-chip coalescence of microemulsions

Embodiments disclosed herein are directed to microfluidic devices that allow for scalable on-chip screening of combinatorial libraries and methods of use thereof. Droplets comprising individual molecular species to be screened are loaded onto the microfluidic device. ... Massachusetts Institute Of Technology

03/15/18 / #20180071215

Core-shell particles for controlled release

Compositions, methods, and systems for controlling crystallization of an agent are generally described. In some embodiments, an agent is crystallized in the presence of polymer matrices, such as polymer particles. ... Massachusetts Institute Of Technology

03/08/18 / #20180068062

Methods for identifying novel gene editing elements

Embodiments disclosed herein provide methods for identifying new crispr loci and effectors, as well as different crispr loci combinations found in various organisms. Class-ii crispr systems contain single-gene effectors that have been engineered for transformative biological discovery and biomedical applications. ... Massachusetts Institute Of Technology

03/08/18 / #20180067065

Ethylene sensor

A sensor device can include a transition metal complex capable of interacting with a carbon-carbon multiple bond moiety. The sensor can detect the fruit-ripening hormone ethylene with high sensitivity.. ... Massachusetts Institute Of Technology

03/08/18 / #20180066242

Crispr-cas systems and methods for altering expression of gene products, structural information and inducible modular cas enzymes

The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the cas protein of the crispr-cas system, use of this information in generating modified components of the crispr complex, vectors and vector systems which encode one or more components or modified components of a crispr complex, as well as methods for the design and use of such vectors and components. ... Massachusetts Institute Of Technology

03/08/18 / #20180066012

Solid phase peptide synthesis processes and associated systems

Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. ... Massachusetts Institute Of Technology

03/01/18 / #20180062163

Lithium hydrogen titanate li-h-ti-o material and method for making the same

A lithium hydrogen titanate li—h—ti—o material includes li, h, ti, and o elements, wherein a mass percentage of li is in a range from about 3% to about 12%, a mass percentage of h is in a range from about 0.1% to about 8%, a mass percentage of ti is in a range from about 46% to about 56%, and a mass percentage of o is in a range from about 28% to about 50%. A lithium ion battery and a method for making the lithium hydrogen titanate li—h—ti—o material are also disclosed.. ... Massachusetts Institute Of Technology








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