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Massachusetts Institute Of Technology patents (2015 archive)


Recent patent applications related to Massachusetts Institute Of Technology. Massachusetts Institute Of Technology is listed as an Agent/Assignee. Note: Massachusetts Institute Of Technology may have other listings under different names/spellings. We're not affiliated with Massachusetts Institute Of Technology, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "M" | Massachusetts Institute Of Technology-related inventors


12/31/15 / #20150381993

Managing transforms for compressing and decompressing visual data

Encoding data includes: encoding a first portion of an array of data to generate a first set of coefficients, using a first transform; decoding the first set of coefficients to generate a decoded approximation of the first portion, using the first transform; selecting a second transform from multiple candidate transforms based at least in part on a measure of encoding performance for each candidate transform used to encode the decoded approximation of the first portion; and encoding a second portion of the array of data in proximity to the first portion of the array of data to generate a second set of coefficients using the selected second transform.. . ... Massachusetts Institute Of Technology

12/31/15 / #20150381659

Cryptography and key management device and architecture

A method for operating a secure device having a plurality of mutually exclusive circuit zones, including a first circuit zone having a first level of security and a second circuit zone having a second level of security less than the first level of security, the method including unpacking a key exchange package including receiving a key exchange package in the second circuit zone, the key exchange package including encrypted key data and processing the encrypted key data using a content key in the first circuit zone to generate decrypted key data and storing the decrypted key data in the first circuit zone without disclosing the decrypted key data into the second circuit zone.. . ... Massachusetts Institute Of Technology

12/31/15 / #20150381592

Cryptography and key management device and architecture

A method for operating a secure device having a plurality of mutually exclusive circuit zones, including a first circuit zone having a first level of security and a second circuit zone having a second level of security less than the first level of security, the method including unpacking a key exchange package including receiving a key exchange package in the second circuit zone, the key exchange package including encrypted key data and processing the encrypted key data using a content key in the first circuit zone to generate decrypted key data and storing the decrypted key data in the first circuit zone without disclosing the decrypted key data into the second circuit zone.. . ... Massachusetts Institute Of Technology

12/31/15 / #20150376811

Electrophoretic-deposited surfaces

A method of altering a property of a surface includes suspending a plurality of low surface energy particles in a solvent, agglomerating the suspension of particles, and subjecting the suspension of particle agglomerates to electrophoretic deposition onto a substrate for a predetermined time. The altered surface may be superhydrophilic or superhydrophobic.. ... Massachusetts Institute Of Technology

12/31/15 / #20150374210

Photometric stereo endoscopy

The present invention relates to systems and methods for photometric endoscope imaging. The methods can further include chromoendoscopy and computer aided detection procedures for the imaging of body lumens and cavities.. ... Massachusetts Institute Of Technology

12/24/15 / #20150372809

Secure network coding for multi-resolution wireless transmission

Described herein is a method and system for hierarchical wireless video with network coding which limits encryption operations to a critical set of network coding coefficients in combination with multi-resolution video coding. Such a method and system achieves hierarchical fidelity levels, robustness against wireless packet loss and efficient security by exploiting the algebraic structure of network coding.. ... Massachusetts Institute Of Technology

12/24/15 / #20150372350

Lubricant-impregnated surfaces for electrochemical applications, and devices and systems using same

In certain embodiments, the invention relates to an electrochemical device having a liquid lubricant impregnated surface. At least a portion of the interior surface of the electrochemical device includes a portion that includes a plurality of solid features disposed therein. ... Massachusetts Institute Of Technology

12/24/15 / #20150372081

Improving linearity in semiconductor devices

A field effect transistor that has a source, a drain, a gate and a semiconductor region. The semiconductor region has a source access region between the gate and the source, a drain access region between the gate and the drain, and a channel region under the gate. ... Massachusetts Institute Of Technology

12/24/15 / #20150371810

Individually switched field emission arrays

An electron beam apparatus is disclosed that includes a plurality of current source elements disposed in at least one field emitter array. Each current source element can be a gated vertical transistor, an ungated vertical transistor, or a current controlled channel that is proximate to an optically-modulated current source. ... Massachusetts Institute Of Technology

12/24/15 / #20150370961

Water-soluble trans-membrane proteins and methods for the preparation and use thereof

The present invention is directed to water-soluble membrane proteins, methods for the preparation thereof and methods of use thereof.. . ... Massachusetts Institute Of Technology

12/24/15 / #20150370960

Water-soluble membrane proteins and methods for the preparation and use thereof

The present invention is directed to water-soluble membrane proteins, methods for the preparation thereof and methods of use thereof.. . ... Massachusetts Institute Of Technology

12/24/15 / #20150369117

Optimized fuel management system for direct injection ethanol enhancement of gasoline engines

Fuel management system for enhanced operation of a spark ignition gasoline engine. Injectors inject an anti-knock agent such as ethanol directly into a cylinder. ... Massachusetts Institute Of Technology

12/24/15 / #20150368625

Artificial sigma factors based on bisected t7 rna polymerase

Aspects of the invention relate to a regulatory system that follows design principles of natural systems but creates novel synthetic biology tools using bisected polymerase proteins.. . ... Massachusetts Institute Of Technology

12/24/15 / #20150368321

Novel full spectrum anti-dengue antibody

The present invention provides, among other things, antibody agents (e.g., antibodies, and/or antigen-binding fragments thereof) that bind to dv epitopes, as well as compositions containing them and methods of designing, providing, formulating, using, identifying and/or characterizing them. In some embodiments, provided antibody agents show significant binding to a plurality of dv serotypes. ... Massachusetts Institute Of Technology

12/24/15 / #20150368121

Multi-stage bubble column humidifier

A feed liquid flows into a second-stage humidifier chamber to form a second-stage humidifier bath. A first remnant of the feed liquid from the second-stage humidifier chamber then flows into a first-stage humidifier chamber to form a first-stage humidifier bath having a temperature lower than that of the second-stage bath. ... Massachusetts Institute Of Technology

12/24/15 / #20150367457

Methods for digital composites

In exemplary implementations of this invention, a digital material comprising many discrete units is used to fabricate a sparse structure. The units are reversibly joined by elastic connections. ... Massachusetts Institute Of Technology

12/17/15 / #20150365956

Cognitive radio method and apparatus for achieving ad hoc interference multiple access wireless communication

In a radio network having a plurality of first users on channel (fuocs) and one or more second users on channel (suocs), a method and apparatus for a suoc to select a channel to co-occupy based in part upon the expected impact on the fuoc. The fuoc collects signal parameters associated with the fuoc, such as actual rate, bandwidth, received signal power, and noise power, and uses the signal parameters to calculate the expected impact. ... Massachusetts Institute Of Technology

12/17/15 / #20150365724

Network coding for multi-resolution multicast

A method, apparatus and computer program product for utilizing network coding for multi-resolution multicast is presented. A network source partitions source content into a base layer and one or more refinement layers. ... Massachusetts Institute Of Technology

12/17/15 / #20150365222

Traffic backfilling via network coding in a multi-packet reception network

Network coding and multiple packet reception (mpr) are used together to improve message dissemination speed in a wireless network using half duplex communication. In at least one embodiment, mpr is used to initially distribute data packets from a number of source nodes in the network to the other nodes of the network. ... Massachusetts Institute Of Technology

12/17/15 / #20150365052

Rf-input / rf-output outphasing amplifier

A power combining and outphasing system and related techniques for simultaneously providing both wide-bandwidth linear amplification and high average efficiency is described. Providing linear amplification encompasses the ability to dynamically control an rf output power level over a wide range while still operating over a wide frequency bandwidth. ... Massachusetts Institute Of Technology

12/17/15 / #20150364307

Systems and methods for single cell culture and analysis by microscopy and maldi mass spectrometry

Systems and methods for single cell culture and analysis by microscopy and matrix assisted laser desorption ionization mass spectrometry are disclosed. The systems and methods isolate a plurality of cells in a plurality of wells such that a predetermined number of the plurality of wells contain one and only one cell. ... Massachusetts Institute Of Technology

12/17/15 / #20150362743

Content-adaptive parallax barriers for automultiscopic display

In exemplary implementations of this invention, two lcd screens display a multi-view 3d image that has both horizontal and vertical parallax, and that does not require a viewer to wear any special glasses. Each pixel in the lcds can take on any value: the pixel can be opaque, transparent, or any shade between. ... Massachusetts Institute Of Technology

12/17/15 / #20150362469

Methods and apparatus for artificial olfaction

In exemplary implementations of this invention, an electronic olfactor determines whether a scent being tested matches the scent of a positive control. The electronic olfactor can perform this scent matching even in a changing olfactory environment, and even if the positive control scent is a combination of hundreds or thousands of different odorants. ... Massachusetts Institute Of Technology

12/10/15 / #20150358136

Method and apparatus for reducing feedback and enhancing message dissemination efficiency in a multicast network

Message dissemination speed is increased during multicast operations in a network by intelligently selecting one or more feedback time slots for use by destination nodes. In at least one implementation, a feedback time slot is selected based upon probabilities that a plurality of data packets will be successfully distributed to a plurality of destination nodes by various future time slots. ... Massachusetts Institute Of Technology

12/10/15 / #20150357975

Hardware-efficient compensator for outphasing power amplifiers

Digital compensators for use in outphasing-based power amplification systems (e.g., linear amplification using nonlinear components (linc) amplifiers and asymmetric multilevel outphasing (amo) amplifiers) include a short memory nonlinear portion and a long memory linear time invariant (lti) portion. In various embodiments, compensators are provided that are of relatively low complexity and that are capable of operation at throughputs exceeding a gigasample per second.. ... Massachusetts Institute Of Technology

12/10/15 / #20150357912

Method and apparatus to provide power conversion with high power factor

A power converter circuit rectifies a line voltage and applies the rectified voltage to a stack of capacitors. Voltages on the capacitors are coupled to a plurality of regulating converters to be converted to regulated output signals. ... Massachusetts Institute Of Technology

12/10/15 / #20150357142

Electromechanical device

Electromechanical devices described herein may employ tunneling phenomena to function as low-voltage switches. Opposing electrodes may be separated by an elastically deformable layer which, in some cases, may be made up of a non-electrically conductive material. ... Massachusetts Institute Of Technology

12/10/15 / #20150354046

Continuous oligocrystalline shape memory alloy wire produced by melt spinning

There is provided herein a shape memory alloy wire that includes an alloy composition of cualmnni and excluding grain refiner elements. The alloy composition includes 20 at %-28 at % al, 2 at %-4 at % ni, 3 at %-5 at % mn with cu as a remaining balance of the alloy composition. ... Massachusetts Institute Of Technology

12/10/15 / #20150353503

Indazole derivatives and uses thereof

The present invention provides novel compounds (e.g., compounds of formula (i)), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits comprising the inventive compounds, or compositions thereof, for treating and/or preventing a fungal or protozoan infection, inhibiting the activity of a fungal or protozoan enzyme, killing a fungus or protozoon, or inhibiting the growth of a fungus or protozoon. ... Massachusetts Institute Of Technology

12/10/15 / #20150352181

Methods for treating tissue damage associated with ischemia with apolipoprotein d

The invention provides methods for treating tissue damage associated with impaired blood flow using apod, or an active variant thereof, or an agent that increases the expression of apod. The invention also encompasses active variants of apod for use in the methods.. ... Massachusetts Institute Of Technology

12/03/15 / #20150348654

Organically cooled nuclear reactor for enhanced economics and safety

An organically cooled nuclear reactor comprises fissionable fuel pellets and a neutron-moderator matrix in which the fissionable fuel pellets are distributed. The neutron-moderator matrix also defines coolant channels for flow of an organic coolant.. ... Massachusetts Institute Of Technology

12/03/15 / #20150348584

Coded seeking apparatus and techniques for data retrieval

Data blocks to be stored on a disk-based data storage device (e.g., a hard disk drive, etc.) are coded together to form a plurality of linearly independent network coded blocks. The network coded blocks are then stored on the data storage device. ... Massachusetts Institute Of Technology

12/03/15 / #20150345839

Thermo-adsorptive battery climate control systems

Thermo-adsorptive batteries can provide the heating and cooling functions by taking advantage of the reversible adsorption/desorption cycles involving the pair of the zeolite adsorbent and condensable vapor adsorbate.. . ... Massachusetts Institute Of Technology

12/03/15 / #20150343444

Hydrodynamic trap array

Hydrodynamic trap array. The array includes a serpentine bypassing channel including a plurality of trapping pockets disposed therein, the trapping pockets including a ramp entry portion to decrease flow velocity orthogonal to the trapping pocket to increase trapping efficiency. ... Massachusetts Institute Of Technology

12/03/15 / #20150343023

Methods for cardioprotection and cardioregeneration with dimers of egf family ligands

The invention provides methods and compositions for reducing, preventing or reversing cardio toxicity side effects associated with certain therapeutic agents. The invention also provides methods and compositions for treating heart dysfunction including heart failure, and for reversing the effects of myocardial infarction. ... Massachusetts Institute Of Technology

11/26/15 / #20150338253

Sensor, method for forming the same, and method of controlling the same

According to embodiments of the present invention, a sensor for determining a flow parameter of a fluid is provided. The sensor includes a polymer membrane, an elongate microstructure extending from the polymer membrane, and a hydrogel coupled to at least a portion of the elongate microstructure, wherein the hydrogel and the elongate microstructure are arranged to cooperate to cause a displacement of the polymer membrane in response to a fluid flowing and interacting with the sensor, and wherein the sensor is configured to provide a measurement indicative of a flow parameter of the fluid based on the displacement of the polymer membrane. ... Massachusetts Institute Of Technology

11/26/15 / #20150337420

Superelastic alloy structural geometry for ultrahigh mechanical damping

A mechanical structure is provided with a crystalline super alloy that is characterized by an average grain size and that exhibits a martensitic phase transformation resulting from a mechanical stress input greater than a characteristic first critical stress. A configuration of the superelastic alloy is provided with a geometric structural feature of the alloy that has an extent that is no greater than about 200 micrometers and that is no larger than the average grain size of the alloy. ... Massachusetts Institute Of Technology

11/26/15 / #20150336092

Compositions comprising functionalized carbon-based nanostructures and related methods

The present invention generally relates to compositions comprising and methods for forming functionalized carbon-based nanostructures.. . ... Massachusetts Institute Of Technology

11/26/15 / #20150335343

Debridement apparatus using linear lorentz-force motors

A debridement device having a controllable lorentz-force actuator is disclosed. The debridement device includes a nozzle delivering a jet of debridement substance to a tissue and the jet is driven by the lorentz-force actuator. ... Massachusetts Institute Of Technology

11/19/15 / #20150331232

Ultra-fast mechanical shutter

An electro-mechanical shutter is described. The fast operation is based on a coil operated via a current, where the coil can move within a set of magnets to provide opening and closing of a shutter. ... Massachusetts Institute Of Technology

11/19/15 / #20150330905

Methods and apparatus for surface classification

In illustrative implementations of this invention, light sources illuminate a surface with multi-spectral, multi-directional illumination that varies in direction, wavelength, coherence and collimation. One or more cameras capture images of the surface while the surface is illuminated under different lighting conditions. ... Massachusetts Institute Of Technology

11/19/15 / #20150329590

Cysteine arylation directed by a genetically encodable pi-clamp

Disclosed are methods of single-site-specific cysteine modification on peptide/protein molecules under physiologically relevant conditions. This process features several significant advantages over existing methods of peptide modification, such as specificity towards thiols over other nucleophiles (e.g., amines, hydroxyls), excellent functional group tolerance, and mild reaction conditions. ... Massachusetts Institute Of Technology

11/19/15 / #20150328838

Systems, devices, and methods for three-dimensional printing

Systems, devices, and methods for three-dimensional printing are provided. The systems, devices, and methods provide for high throughput printing by allowing for parallel extrusion within a single vertical layer of the printed object, i.e., parallel extrusion within an x-y coordinate plane. ... Massachusetts Institute Of Technology

11/12/15 / #20150321921

Silica aerogels and their preparation

Silica aerogels with improved properties are disclosed together with methods for synthesizing such aerogels. The improved properties include lower thermal conductivity (better insulating capacity), lower acoustic velocity, lower dielectric constant and improved ductility. ... Massachusetts Institute Of Technology

11/12/15 / #20150321408

Continuous fabrication system and method for highly aligned polymer films

Process for continuous fabrication of highly aligned polymer films. A polymer-solvent solution is subjected to a high shear, high temperature, couette flow to extrude a thin film having polymer chain disentanglement. ... Massachusetts Institute Of Technology

11/12/15 / #20150321118

Multi-stage bubble column humidification and dehumidification

A feed liquid flows into a second-stage humidifier chamber to form a second-stage humidifier bath. A first remnant of the feed liquid from the second-stage humidifier chamber then flows into a first-stage humidifier chamber to form a first-stage humidifier bath having a temperature lower than that of the second-stage bath. ... Massachusetts Institute Of Technology

11/12/15 / #20150320560

Radiolucent cranial implants for neural applications

Cranial implants, kits including cranial implants, and methods of making cranial implants are described. The cranial implants may be radiolucent. ... Massachusetts Institute Of Technology

11/05/15 / #20150319540

Method and apparatus for recovering audio signals from images

A method of recovering audio signals and corresponding apparatus according to an embodiment of the present invention using video or other sequence of images enables recovery of sound that causes vibrations of a surface. An embodiment method includes combining representations of local motions of a surface to produce a global motion signal of the surface. ... Massachusetts Institute Of Technology

11/05/15 / #20150318360

Reducing leakage current in semiconductor devices

A semiconductor device includes a first region having a first semiconductor material and a second region having a second semiconductor material. The second region is formed over the first region. ... Massachusetts Institute Of Technology

11/05/15 / #20150315576

Genetic device for the controlled destruction of dna

The invention relates to dna destruction devices and related methods reagents and kits. The dna destruction devices are useful for achieving target specific dna destruction in vivo using a system that involves an actuator element and a crispr array, under specific regulatory control.. ... Massachusetts Institute Of Technology

11/05/15 / #20150315574

Production of stable non-polyadenylated rnas

The invention relates in aspects to hybrid rnas lacking a poly-a tail and nucleic acid vectors for expressing the rna. The hybrid rnas in some instances have a 3′ terminal stabilizing triple helical structure. ... Massachusetts Institute Of Technology

11/05/15 / #20150315570

Directed evolution of synthetic gene cluster

The invention relates to methods and products for generating diverse libraries of genetic material. The products include libraries and constructed nucleic acids as well as kits and databases and systems thereof.. ... Massachusetts Institute Of Technology

11/05/15 / #20150315242

Self-assembling peptide and peptide gel with high strength

Provide are a peptide gel with practically sufficient mechanical strength and a self-assembling peptide capable of forming the peptide gel. The self-assembling peptide is formed of the following amino acid sequence: a1b1c1b2a2b3db4a3b5c2b6a4 where: a1 to a4 each represent a basic amino acid residue; b1 to b6 each represent an uncharged polar amino acid residue and/or a hydrophobic amino acid residue, provided that at least five thereof each represent a hydrophobic amino acid residue; c1 and c2 each represent an acidic amino acid residue; and d represents a hydrophobic amino acid residue.. ... Massachusetts Institute Of Technology

11/05/15 / #20150313798

Adaptor for removal of fluid from vial using a needle-free syringe

A needle-free adaptor for removing liquid from a vial comprises a cannula adapted to piece a septum of a vial, a plurality of legs surrounding the cannula to secure the adaptor to the vial when the cannula has pieced the septum, an elastomeric membrane having a normally closed pinhole orifice, and a conforming surface having an orifice connected to the cannula. The elastomeric membrane has a stable convex shape and is adapted to receive a nozzle of a needle-free device. ... Massachusetts Institute Of Technology

10/29/15 / #20150311982

Devices and techniques for integrated optical data communication

Devices and techniques for integrated optical data communication. An optical receiver may include a photodetector and a differential amplifier. ... Massachusetts Institute Of Technology

10/29/15 / #20150311971

Method and apparatus for smart adaptive dynamic range multiuser detection radio receiver

A receiver includes multi-user detection (mud) functionality and a cognitive engine. The receiver may also be coupled to multiple antennas and have analog beamforming capability. ... Massachusetts Institute Of Technology

10/29/15 / #20150311664

Method and applications of thin-film membrane transfer

The disclosure relates to method and apparatus for micro-contact printing of micro-electromechanical systems (“mems”) in a solvent-free environment. The disclosed embodiments enable forming a composite membrane over a parylene layer and transferring the composite structure to a receiving structure to form one or more microcavities covered by the composite membrane. ... Massachusetts Institute Of Technology

10/29/15 / #20150311401

Thermo-electrically pumped light-emitting diodes

Contrary to conventional wisdom, which holds that light-emitting diodes (leds) should be cooled to increase efficiency, the leds disclosed herein are heated to increase efficiency. Heating an led operating at low forward bias voltage (e.g., v<kbt/q) can be accomplished by injecting phonons generated by non-radiative recombination back into the led's semiconductor lattice. ... Massachusetts Institute Of Technology

10/29/15 / #20150311363

Nanowire-modified graphene and methods of making and using same

A transparent electrode can include a graphene sheet on a substrate, a layer including a conductive polymer disposed over the graphene sheet, and a plurality of semiconducting nanowires, such as zno nanowires, disposed over the layer including the conductive polymer.. . ... Massachusetts Institute Of Technology

10/29/15 / #20150309306

Applications of contact-transfer printed membranes

The disclosed embodiments provide sensitive pixel arrays formed using solvent-assisted or unassisted release processes. Exemplary devices include detectors arrays, tunable optical instruments, deflectable minors, digital micro-mirrors, digital light processing chips, tunable optical micro-cavity resonators, acoustic sensors, acoustic actuators, acoustic transducer devices and capacitive zipper actuators to name a few.. ... Massachusetts Institute Of Technology

10/29/15 / #20150308015

Formation of core-shell fibers and particles by free surface electrospinning

Disclosed are methods that utilize the differences in physical properties between two coating fluids to form core-shell particles or core-shell fibers by coaxial free-surface electrospinning. The methods are able to achieve higher productivity than known methods, and are tunable. ... Massachusetts Institute Of Technology

10/29/15 / #20150307385

Methods and apparatus for additive manufacturing of glass

In illustrative implementations of this invention, a crucible kiln heats glass such that the glass becomes or remains molten. A nozzle extrudes the molten glass while one or more actuators actuate movements of the nozzle, a build platform or both. ... Massachusetts Institute Of Technology

10/29/15 / #20150306642

Apparatus and methods employing liquid-impregnated surfaces

In certain embodiments, the invention is directed to apparatus comprising a liquid-impregnated surface, said surface comprising an impregnating liquid and a matrix of solid features spaced sufficiently close to stably contain the impregnating liquid therebetween or therewithin, and methods thereof. In some embodiments, one or both of the following holds: (i) 0<φ≦0.25, where φ is a representative fraction of the projected surface area of the liquid-impregnated surface corresponding to non-submerged solid at equilibrium; and (ii) sow(a)<0, where sow(a) is spreading coefficient, defined as γwa−γwo−γoa, where γ is the interfacial tension between the two phases designated by subscripts w, a, and o, where w is water, a is air, and o is the impregnating liquid.. ... Massachusetts Institute Of Technology

10/29/15 / #20150306590

Carbon-dioxide compound and catalyst

Tetrahedral [moo4]2− readily binds co2 to produce a robust [moo3(κ2-co3)]2− that can affect the reduction of co2 to formate.. . ... Massachusetts Institute Of Technology

10/22/15 / #20150304979

Characterizing multipath delays in antenna array and synthetic aperture radar systems

Multiple radio transmissions are processed to determine, for each of a number of directions of arrival of the radio transmissions, a most direct direction of arrival, for example, to distinguish a direct path from a reflected path from the target. In some examples, the radio transmissions include multiple frequency components, and channel characteristics at different frequencies are compared to determine the direct path.. ... Massachusetts Institute Of Technology

10/22/15 / #20150304534

Methods and apparatus for demultiplexing illumination

In illustrative implementations of this invention, an imaging system includes multiple light sources that illuminate a scene, and also includes a lock-in time of flight camera. While the scene is illuminated by these light sources, each of the light sources is amplitude-modulated by a different modulation pattern, and a reference signal is applied to the lock-in time-of-flight camera. ... Massachusetts Institute Of Technology

10/22/15 / #20150304419

Random linear coding approach to distributed data storage

A method and computer program product for providing a random linear coding approach to distributed data storage is presented. A file is broken into a plurality of pieces. ... Massachusetts Institute Of Technology

10/22/15 / #20150303525

Liquid metal alloy energy storage device

An energy storage device configured to exchange energy with an external device includes a container having walls, a lid covering the container and having a safety pressure valve, a negative electrode disposed away from the walls of the container, a positive electrode in contact with at least a portion of the walls of the container, and an electrolyte contacting the negative electrode and the positive electrode at respective electrode/electrolyte interfaces. The negative electrode, the positive electrode and the electrolyte include separate liquid materials within the container at an operating temperature of the battery.. ... Massachusetts Institute Of Technology

10/22/15 / #20150303064

Developer free positive tone lithography by thermal direct write

A method for lithographic patterning of thin films. A thin film is deposited on a substrate and the film is exposed to optical energy from a focused laser to induce a thermal gradient in the film by optical absorption. ... Massachusetts Institute Of Technology

10/22/15 / #20150301380

Methods and apparatus for light harvesting in displays

Methods and apparatuses for harvesting light from displays. In one embodiment, the invention relates to a substrate having a first and a second surface, an edge and a luminescent dye. ... Massachusetts Institute Of Technology

10/22/15 / #20150301152

Localization with non-synchronous emission and multipath transmission

Directional characterization of a location of a target device makes use of multiple radio transmissions that are received from the target device. In some examples, each radio transmission is received at a first antenna at a fixed location, and is also received at a second moving antenna. ... Massachusetts Institute Of Technology

10/22/15 / #20150299233

Compositions and methods comprising rhenium for the treatment of cancers

Compositions and methods comprising rhenium are provided. In some embodiments, the rhenium compounds comprise a bidentate ligand. ... Massachusetts Institute Of Technology

10/22/15 / #20150298827

Attitude determination using infrared earth horizon sensors

Described herein are systems and methods for attitude determination using infrared earth horizon sensors (ehss) with gaussian response characteristics. Attitude information is acquired by detecting earth's infrared electromagnetic radiation and, subsequently, determining the region obscured by earth in the sensors' fields of view to compute a nadir vector estimation in the spacecraft's body frame. ... Massachusetts Institute Of Technology

10/22/15 / #20150298089

Systems for filling a sample array by droplet dragging

A method and an array filling system for loading a plurality of disparate sample containers, the sample containers comprising an integral structure. Each receptacle is characterized by a hydrophilic surface,, and the receptacles are separated by a hydrophobic surface. ... Massachusetts Institute Of Technology

10/22/15 / #20150297799

Methods and compositions for the treatment of open and closed wound spinal cord injuries

Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. ... Massachusetts Institute Of Technology

10/22/15 / #20150297691

Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness

The invention relates to methods of protecting against chronic stress in a subject and treating stress sensitive disorders in a subject by antagonizing ghrelin or ghrelin receptor.. . ... Massachusetts Institute Of Technology

10/22/15 / #20150297458

Rapid reconstitution packages for mixing and delivery of drugs

Rapid reconstitution package. The package includes a substantially cylindrical structure including a diluent chamber and a drug chamber communicating through a valve. ... Massachusetts Institute Of Technology

10/01/15 / #20150282189

Cognitive radio method and apparatus for achieving ad hoc interference multiple access wireless communication

An suoc radio employs: (1) spectrum sensing and parameter estimation methods to characterize potential fuocs; (2) a rate pair prediction tool to guide it's choice of fuoc to target along with the appropriate rate pair (suoc and fuoc achievable rates); (3) machine learning methods to automatically and on the fly advantage experience/history; (4) a decision maker with multiple possible procedures that govern steps of interaction; (5) multiuser detection receiver to deal with the interference once information-bearing transmission has commenced by the suoc radios. (6) a radio capable of full transmit-processing chain to accomplish modulation and full receive-processing chain to accomplish demodulation, as well as other radio functions necessary for successful wireless communications such as medium access control, networking and other functions.. ... Massachusetts Institute Of Technology

10/01/15 / #20150282176

Method and apparatus for rate determination in a radio frequency system

Techniques are described for determining rates and other parameters for users associated with a multiple access channel (mac). In at least one embodiment, a rate determination tool having a gui interface is provided.. ... Massachusetts Institute Of Technology

10/01/15 / #20150280614

Electric field activation of shape memory ceramics

Articles and methods in which an electric field is used to actuate a material are generally described. Provided in one embodiment is a method including applying an electric field to a ceramic material. ... Massachusetts Institute Of Technology

10/01/15 / #20150280553

Power converter with capacitive energy transfer and fast dynamic response

A converter circuit and related technique for providing high power density power conversion includes a reconfigurable switched capacitor transformation stage coupled to a magnetic converter (or regulation) stage. The circuits and techniques achieve high performance over a wide input voltage range or a wide output voltage range. ... Massachusetts Institute Of Technology

10/01/15 / #20150278635

Methods and apparatus for learning representations

Systems and methods for processing an input signal. In some embodiments, an input pattern in the input signal may be combined with each stored representation of a plurality of stored representations of at least one template to obtain a respective value for each stored representation, thereby obtaining a plurality of values. ... Massachusetts Institute Of Technology

10/01/15 / #20150273085

Short-wavelength infrared (swir) fluorescence in vivo and intravital imaging with semiconductor nanocrystals

Inas based core-shell particles which leads to tunable, narrow emitting semiconductor nanocrystals with a very high quantum yield which can be preserved in physiological buffers with long stability can used for short wavelength infrared (swir) imaging. Increased resolution with reduced read time and increased imaging frequency can provide advantages in in vivo applications.. ... Massachusetts Institute Of Technology

10/01/15 / #20150272899

Blood clotting control

The disclosure is directed to enabling reversible, on-demand remote control of blood clotting and clot dissolution. In one embodiment, a laser at one wavelength triggers release of a dna thrombin inhibitor from one nanorod, which acts as an anticoagulant to stop blood clotting. ... Massachusetts Institute Of Technology

10/01/15 / #20150272884

Lipid vesicle compositions and methods of use

The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.. ... Massachusetts Institute Of Technology

10/01/15 / #20150272504

Apparatus and method for motor function characterization

Analysis of keystroke dynamics performed by an individual can be used for assessment and monitoring of the individual's motor function. Keystroke events related to a user pressing one or more keys on a keyboard or regions on a touch screen may be analyzed to identify a plurality of distributions of keystroke event intervals. ... Massachusetts Institute Of Technology

09/24/15 / #20150271453

Imaging systems and methods for immersive surveillance

Security guards at large facilities, such as airports, monitor multiple screens that display images from individual surveillance cameras dispersed throughout the facility. If a guard zooms with a particular camera, he may lose image resolution, along with perspective on the surrounding area. ... Massachusetts Institute Of Technology

09/24/15 / #20150270992

Digital transmitter

An equalizer provided in a digital transmitter compensates for attenuation in a signal channel to a digital receiver. The equalizer generates signal levels as a logical function of bit history to emphasize transition signal levels relative to repeated signal levels. ... Massachusetts Institute Of Technology

09/24/15 / #20150270356

Vertical nitride semiconductor device

A vertical semiconductor device and a method of forming the same. A vertical semiconductor device has a substrate that includes a first material, a first electrode below the substrate, and at least one semiconductor region. ... Massachusetts Institute Of Technology

09/24/15 / #20150268461

Applications of contact-transfer printed membranes

The disclosed embodiments provide sensitive pixel arrays formed using solvent-assisted or unassisted release processes. Exemplary devices include detectors arrays, tunable optical instruments, deflectable mirrors, digital micro-mirrors, digital light processing chips, tunable optical micro-cavity resonators, acoustic sensors, acoustic actuators, acoustic transducer devices and capacitive zipper actuators to name a few.. ... Massachusetts Institute Of Technology

09/24/15 / #20150268223

Micropatterned co-culture systems as infectious disease analysis platforms

Cell cultures are provided that include a population of micropatterened hepatocytes and one or more non-parenchymal cell populations, where the hepatocytes are infected with a virus or parasite and include a reporter of virus or parasite infection. Methods of making and using the cell cultures are also provided.. ... Massachusetts Institute Of Technology

09/24/15 / #20150266946

Treatment of age-related and mitochondrial diseases by inhibition of hif-1 alpha function

Disclosed herein are novel compositions and methods for the treatment of age-related diseases, mitochondrial diseases, the improvement of stress resistance, the improvement of resistance to hypoxia and the extension of life span. Also described herein are methods for the identification of agents useful in the foregoing methods. ... Massachusetts Institute Of Technology

09/24/15 / #20150265956

Discrete bypass particle concentrator

A discrete bypass particle concentrator can significantly reduce surface fouling and manufacturing cost by including bypass stages after each of concentration stages.. . ... Massachusetts Institute Of Technology

09/24/15 / #20150265716

Nanoparticles for targeted delivery of multiple therapeutic agents and methods of use

Provided herein are compositions that contain a nanoparticle containing a plurality of polymers, wherein at least a fraction of the polymers comprise a hydrophobic polymer, a topoisomerase inhibitor, and a pt-containing chemotherapeutic agent, where the polymers self-assemble in an aqueous liquid to form the nanoparticle, and where the pt-containing chemotherapeutic agent and the topoisomerase inhibitor are present within the hydrophobic core of the nanoparticle in a ratio of between about 24:1 to about 1:24. Also provided are methods of reducing the proliferation of a cancer cell and methods of treating cancer in a subject that include the use of these compositions. ... Massachusetts Institute Of Technology

09/24/15 / #20150265161

Methods and apparatus for physiological parameter estimation

In illustrative implementations, a gyroscope, an accelerometer and a camera gather sensor data indicative of motion of a human head. The gyroscope, accelerometer and camera are each housed in, or attached to, headwear that is worn on the head. ... Massachusetts Institute Of Technology

09/17/15 / #20150263606

Level-crossing based circuit and method with offset voltage cancellation

A level-crossing based circuit with offset voltage cancellation includes a first level-crossing detector section having a first output capacitor, wherein the first level-crossing section is configured to charge the first output capacitor to a first voltage corresponding to an input signal. The first voltage includes a first offset voltage. ... Massachusetts Institute Of Technology

09/17/15 / #20150262760

Plasmon-enhanced dye-sensitized solar cells

A dye-sensitized solar cell can include a plurality of a plasmon-forming nanostructures. The plasmon-forming nanostructures can include an oxide core, an inner metallic shell on a surface of the oxide core, and an outer oxide shell on a surface of the inner metallic shell.. ... Massachusetts Institute Of Technology

09/17/15 / #20150260769

Contact-independent electrical conductance measurement

Electrical conductance measurement system including a one-dimensional semiconducting channel, with electrical conductance sensitive to electrostatic fluctuations, in a circuit for measuring channel electrical current. An electrically-conductive element is disposed at a location at which the element is capacitively coupled to the channel; a midpoint of the element aligned with about a midpoint of the channel, and connected to first and second electrically-conductive contact pads that are together in a circuit connected to apply a changing voltage across the element. ... Massachusetts Institute Of Technology

09/17/15 / #20150259435

Her2- and vegf-a-binding proteins with enhanced stability

The invention provides her2-binding proteins and vegf-a-binding proteins having a reduced tendency to aggregate. Compositions and methods of use are also provided.. ... Massachusetts Institute Of Technology

09/17/15 / #20150259381

High affinity metal-oxide binding peptides with reversible binding

A dodecamer peptide, and its modified variant, having a repeating glycine-lysine sequence was created and found to bind with high affinity to oxide surfaces and certain activated polymeric surfaces. Reversible binding characteristics of the peptides were demonstrated. ... Massachusetts Institute Of Technology

09/10/15 / #20150257238

Methods and apparatus for illumination control

In exemplary embodiments of this invention, one or more i/o devices accept input from a human user. The input is indicative of a value for each control variable in a set of separate control variables. ... Massachusetts Institute Of Technology

09/10/15 / #20150256354

Efficient transmission of information to multiple nodes using cooperative feedback requests

A system and method to reduce the number of data transmissions between nodes in a network is described. In one embodiment, a system and method for reducing the amount of ack and nak traffic in a network is described.. ... Massachusetts Institute Of Technology

09/10/15 / #20150255549

Controlling gaasp/sige interfaces

Initiation conditions and strain techniques are described that enable forming high quality gaasp semiconductor material on an sige semiconductor material with low threading defect density. Suitable initiation conditions include exposing the sige semiconductor material to a gas comprising arsenic. ... Massachusetts Institute Of Technology

09/10/15 / #20150253237

Method and apparatus for tracking cell identity

A method of tracking cell identity across analytical platforms uses stochastic barcoding (sb). Sb uses a randomly generated code based on one or more of the number, color and position of beads encapsulated together with a set of cells of interest. ... Massachusetts Institute Of Technology

09/10/15 / #20150252412

High-definition dna in situ hybridization (hd-fish) compositions and methods

The invention provides methods and compositions relating to high definition fluorescence dna in situ hybridization (hd-fish). The probes generated using the methods of the invention demonstrate higher resolution and efficacy than conventional dna fish probes.. ... Massachusetts Institute Of Technology

09/10/15 / #20150252336

Split peroxidases and methods of use

An imaging method utilizing a split peroxidase is described herein. Imaging methods involve contacting a cell with a split peroxidase and a substrate thereof to allow conversion of a substrate into a product via an enzymatic reaction catalyzed by the reconstitute split peroxidase. ... Massachusetts Institute Of Technology

09/10/15 / #20150250739

Multilayer compositions, coated devices and use thereof

The present invention provides, among other things, multilayer film coating compositions, coated substrates and methods thereof. In some embodiments, a structure, comprising a substrate and a multilayer film on the substrate, wherein the multilayer film comprises a release layer and one or more layer-by-layer films. ... Massachusetts Institute Of Technology

09/03/15 / #20150247832

Gas sensors based upon metal carbon complexes

. . A sensor can include a conductive region in electrical communication with at least two electrodes, the conductive region including a conductive material and an alkene-interacting metal complex.. . ... Massachusetts Institute Of Technology

09/03/15 / #20150246354

Cell rolling separation

The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and edges are disclosed.. ... Massachusetts Institute Of Technology

08/27/15 / #20150240008

Catalysts and methods for ring opening metathesis polymerization

The present invention, among other things, provides highly syndiotactic poly(dicyclopentadiene) and/or hydrogenated poly(dicyclopentadiene), compositions thereof, and compounds and methods for preparing the same. In some embodiments, a provided compound is a compound of formula i, ii or iii. ... Massachusetts Institute Of Technology

08/27/15 / #20150239977

Cd20- and egfr-binding proteins with enhanced stability

The invention provides cd20-binding proteins and egfr-binding proteins having a reduced tendency to aggregate. Compositions and methods of use are also provided.. ... Massachusetts Institute Of Technology

08/20/15 / #20150236526

Wireless power transfer

A method includes determining, by a base station including a number of transmitting coils, a first number of mutual magnetic parameters, each mutual magnetic parameter being associated with one of the transmitting coils and a receiving coil of at least one receiving coil associated with at least one electronic device remotely located from and to be remotely charged by the base station, determining a plurality of control signals based on the first number of mutual magnetic parameters, each control signal being associated with a corresponding one of the transmitting coils, providing each control signal to a driving circuit coupled to the control signal's corresponding transmitting coil, and using each control signal to cause the driving circuit coupled to the control signal's corresponding transmitting coil to cause a current with a magnitude and phase determined from the control signal to flow in the corresponding transmitting coil.. . ... Massachusetts Institute Of Technology

08/20/15 / #20150234270

Microstructure synthesis by flow lithography and polymerization

In a method for synthesizing polymeric microstructures, a monomer stream is flowed, at a selected flow rate, through a fluidic channel. At least one shaped pulse of illumination is projected to the monomer stream, defining in the monomer stream a shape of at least one microstructure corresponding to the illumination pulse shape while polymerizing that microstructure shape in the monomer stream by the illumination pulse. ... Massachusetts Institute Of Technology

08/20/15 / #20150233440

Beam-based nonlinear spring

Nonlinear spring. In one embodiment, the spring includes two opposed curved surfaces curving away from one another. ... Massachusetts Institute Of Technology

08/20/15 / #20150232883

Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components

The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery particle formulations and/or systems comprising one or more components of a crispr-cas system, which are means for targeting sites for delivery. ... Massachusetts Institute Of Technology

08/20/15 / #20150230901

Layered medium for three-dimensional imaging

The attenuation and other optical properties of a medium are exploited to measure a thickness of the medium between a sensor and a target surface. Disclosed herein are various mediums, arrangements of hardware, and processing techniques that can be used to capture these thickness measurements and obtain three-dimensional images of the target surface in a variety of imaging contexts. ... Massachusetts Institute Of Technology

08/20/15 / #20150230707

Buffered body return receiver

Buffered body return receiver configurations are described. An amplifier for a receiver can be connected to two electrodes such that one of the two electrodes is connected to a non-inverting input of the amplifier and a second of the two electrodes is a driven node by being connected to both the inverting input of the amplifier and the output of the amplifier. ... Massachusetts Institute Of Technology

08/13/15 / #20150229910

Method and apparatus for stereoscopic imaging

A device is disclosed that utilizes color or polarization to generate two separate images of the same object taken from the two perspectives that correspond to the left and right eyes of an observer. The two separate images are captured through a single camera objective (e.g., a single shutter camera), resulting in a single image with 3d information encoded in the color or polarization. ... Massachusetts Institute Of Technology

08/13/15 / #20150228916

Bottom-up ultra-thin functional optoelectronic films and devices

The embodiments disclosed herein are directed to optoelectronic devices based, on ultra-thin, lightweight and in-situ deposited parylene substrates, as well as methods of manufacture. Using a bottom-up approach, a readily releasable parylene thin film can be used for fabricating thin film electronic and optoelectronic systems on the thin and light substrates having thicknesses in the nanometer to low micron range. ... Massachusetts Institute Of Technology

08/13/15 / #20150228805

Electronically controlled squishable composite switch

A method and apparatus for making analog and digital electronics which includes a composite including a squishable material doped with conductive particles. A microelectromechanical systems (mems) device has a channel made from the composite, where the channel forms a primary conduction path for the device. ... Massachusetts Institute Of Technology

08/13/15 / #20150225692

Programmable drug delivery profiles of tumor-targeted bacteria

The present invention relates to composition comprising at least one non-pathogenic bacterial cell, wherein the non-pathogenic bacterial cell comprises at least a first and a second nucleic acid sequence, the first nucleic acid sequence comprising at least one non-constitutive promoter operably linked to the second nucleic acid sequence that encodes therapeutic agent, wherein the non-constitutive promoter is an inducible promoter responsive to at least one stimuli and the at least one stimuli comprises the presence of a certain density or a certain number of bacterial cells comprising the first and second nucleic acid sequences.. . ... Massachusetts Institute Of Technology

08/13/15 / #20150225438

Suprametallogels and uses thereof

The disclosure provides nanostructures (e.g., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e.g., pd(ii)-, ni(ii)-, or fe(ii)-ligand of formula (a)) coordination and junction self-assembly. The disclosure also provides supramolecular complexes that include the nanostructures connected by divalent linkers y. ... Massachusetts Institute Of Technology

08/06/15 / #20150222238

Switched capacitor circuits having level-shifting buffer amplifiers, and associated methods

Switched capacitor circuits and charge transfer methods comprising a sampling phase and a transfer phase. Circuits and methods are implemented via a plurality of switches, a set of at least two capacitors, at least one buffer amplifier, and an operational amplifier. ... Massachusetts Institute Of Technology

08/06/15 / #20150219673

The use of gene expression profiling as a biomarker for assessing the efficacy of hdac inhibitor treatment in neurodegenerative conditions

The present invention relates to methods, arrays, and kits for identifying alzheimer's disease phenotype and for assessing the efficacy of putative ad therapies. In some aspects provided, is a method of identifying the presence of an alzheimer's disease phenotype in a subject comprising: performing an assay to measure an expression pattern of at least one alzheimer's associated gene.. ... Massachusetts Institute Of Technology

08/06/15 / #20150219559

Fluorescent contact imaging for in-process print sensing

System for visualization of conformal contact. The system visualizes conformal contact between a patterned stamp and a transparent impression surface. ... Massachusetts Institute Of Technology

08/06/15 / #20150218645

Methods and products related to targeted cancer therapy

The invention relates to methods and related products for treatment and determining modes of treatment for cancer or prognosis of cancer. Preferably the methods are related to the induction of cd80 in p53 responsive cancer cells.. ... Massachusetts Institute Of Technology

08/06/15 / #20150217444

Wearable robot assisting manual tasks

A wearable robotic system assists a wearer in performing manual tasks. One or more robotic arms are mounted to a wearer, and an sensor monitors the orientation(s) (e.g., position and movement) of the wearer's upper body and one or both arms. ... Massachusetts Institute Of Technology

07/30/15 / #20150215353

Tangible social network

A tangible social network system comprises at least two interactive physical objects adapted for communicatively linking with each other, a visualization application for providing a visual representation of a user's tangible social network, and an object communication frame. An interactive physical object comprises a controller for forming a communicatively linked relationship with another interactive physical object and for receiving and responding to commands and data received from a linked object, and an audio or visual response subsystem. ... Massachusetts Institute Of Technology

07/30/15 / #20150214579

Alkali metal ion battery with bimetallic electrode

Electrochemical cells having molten electrodes having an alkali metal provide receipt and delivery of power by transporting atoms of the alkali metal between electrode environments of disparate chemical potentials through an electrochemical pathway comprising a salt of the alkali metal. The chemical potential of the alkali metal is decreased when combined with one or more non-alkali metals, thus producing a voltage between an electrode comprising the molten alkali metal and the electrode comprising the combined alkali/non-alkali metals.. ... Massachusetts Institute Of Technology

07/30/15 / #20150213991

Microplasma generation devices and associated systems and methods

Microplasma generators and associated arrays and methods are described herein. Certain embodiments relate to a microplasma generator in which an elongated semiconductor structure can control electronic cun'ent supplied to a microplasma cavity. ... Massachusetts Institute Of Technology

07/30/15 / #20150213930

No-insulation multi-width winding for high temperature superconducting magnets

An hts magnet having a stack of a plurality of double-pancake (dp) coils is disclosed, with each dp coil having a first superconducting coil and a second superconducting coil. The plurality of dp coils have varying widths, with dp coils with the widest widths at the top and bottom of the stack, and dp coils with the narrowest coils located substantially at a midpoint of the stack. ... Massachusetts Institute Of Technology

07/30/15 / #20150213187

System for introspection and annotation of electronic design data

A system for introspection and annotation of electronic design data includes a tracked probe that interacts with an electronic circuit, a tracking system, schematics, design files, or models for the circuit, electronic design system software, and a user interface. The probe has a sensor that tracks the position of the probe within the circuit. ... Massachusetts Institute Of Technology

07/30/15 / #20150211067

Neuropsychiatric disorder-associated mutations and uses thereof

Provided herein are methods and compositions for identifying subjects as having an elevated risk of developing or having a neuropsychiatric disorder. These subjects are identified based on the presence of one or more mutations.. ... Massachusetts Institute Of Technology

07/30/15 / #20150210350

Wheel spoking systems and methods of manufacturing and installing wheel spokes

Embodiments of hybrid sensor-enabled and autonomous electric wheels can include a plurality of systems and devices integrated into a single compact hub unit that can be retrofitted into numerous types of two-wheeled bicycles. In one embodiment, an electrically motorized bicycle wheel can include a wheel rim, a wheel hub having an electric motor, a battery pack and a control unit configured to control a drive torque of the electric motor, and a plurality of wheel spokes connecting the wheel rim to the wheel hub. ... Massachusetts Institute Of Technology

07/30/15 / #20150209750

Method for preparing a slurry of pulverized solid material in liquid or supercritical carbon dioxide

Method for making a slurry of a pulverized solid in liquid or supercritical carbon dioxide. The method includes making a water-pulverized solid slurry at ambient pressure and pressurizing the water-pulverized solid slurry to a high pressure. ... Massachusetts Institute Of Technology

07/30/15 / #20150209509

Methods and devices for inserting a needle

An apparatus provides targeted placement of openings for infusing fluids into a body. The apparatus provides a driving force to a penetrating medical device, such as a needle, when the apparatus tip encounters material of high resistance. ... Massachusetts Institute Of Technology

07/30/15 / #20150209359

Combination therapies and methods of use thereof for treating cancer

Pharmaceutical compositions including an effective amount of an antiandrogen or androgen antagonist in combination with a plk inhibitor and methods of use thereof for treating cancer are disclosed. Administration of the combination of the active agents can be effective to reduce cancer cell proliferation or viability in a subject with cancer to the same degree, or a greater degree than administering to the subject the same amount of either active agent alone. ... Massachusetts Institute Of Technology

07/30/15 / #20150209214

Optimal design of a lower limb exoskeleton or orthosis

A link extends between a distal member and a proximal member of a wearable device, such as an exoskeleton, orthosis or prosthesis for a human lower limb. One or other of the distal member and the proximal member includes a crossing member. ... Massachusetts Institute Of Technology

07/23/15 / #20150205912

Methods to identify amino acid residues involved in macromolecular binding and uses therefor

The present disclosure relates to methods and computational tools based, at least in part, on computer simulations that identify hot-spot amino acid residues and binding-region amino acid residues of a protein.. . ... Massachusetts Institute Of Technology

07/23/15 / #20150204809

Screening solid state ionic conductors for high ionic conductivity

Non-normal statistics applied to diffusivity calculations accelerate screening of ionic conductors for electrochemical devices such as electric storage batteries, fuel cells, and sensors. Displacements of atomic species within a crystalline structure for a candidate ionic conductor material are analyzed using a skellam distribution optionally combined with gaussian noise to calculate values for the standard deviation, upper error bound, and lower error bound for predicted values of diffusivity (d). ... Massachusetts Institute Of Technology

07/23/15 / #20150203880

Co-culture based modular engineering for the biosynthesis of isoprenoids, aromatics and aromatic-derived compounds

The invention relates to co-cultures and their use in the biosynthesis of functionalized taxanes, other isoprenoids, aromatics, and aromatic-derived compounds.. . ... Massachusetts Institute Of Technology

07/23/15 / #20150203872

Crispr-cas systems and methods for altering expression of gene products

The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which encode one or more components of a crispr complex, as well as methods for the design and use of such vectors. ... Massachusetts Institute Of Technology

07/23/15 / #20150203751

Highly luminescent color-selective nanocrystalline materials

A nanocrystal capable of light emission includes a nanoparticle having photoluminescence having quantum yields of greater than 30%.. . ... Massachusetts Institute Of Technology

07/23/15 / #20150203439

Aminoalcohol lipidoids and uses thereof

Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. ... Massachusetts Institute Of Technology

07/23/15 / #20150203371

Liquid separation device

A device for separating liquids such as oil and water includes a hydrophobic and oleophilic mesh that allows oil to pass through while preventing water from passing through. The mesh can be fabricated simply from inexpensive materials by coating a mesh with a hydrophobic polymer.. ... Massachusetts Institute Of Technology

07/23/15 / #20150202606

High charge density structures, including carbon-based nanostructures and applications thereof

The present invention generally provides compositions including carbon-based nanostructures, catalyst materials and systems, and related methods. In some cases, the present invention relates to carbon-based nanostructures comprising a high density of charged moieties. ... Massachusetts Institute Of Technology

07/16/15 / #20150199424

Knowledge registry systems and methods

Systems and methods are disclosed that provide high-level, ontology-based analysis of low-level data stored within an unstructured key/value store. The systems and methods allow an analyst to make sense of massive amounts of data from diverse sources without having any knowledge of the underlying physical data storage. ... Massachusetts Institute Of Technology

07/16/15 / #20150199358

System and method for providing unidimensional scale extraction from a multidimensional entity

A method is provided for deriving a unidimensional scale from an object having multiple attributes. An object and a set of attributes for the object are determined. ... Massachusetts Institute Of Technology

07/16/15 / #20150198722

Travel survey systems and methods

Systems and methods for collecting travel data include a mobile application capable of being executed on a mobile computing device and configured to monitor and log travel data related to travel of the mobile computing device, and to communicate the travel data over a network. A networked data processing device may be coupled to receive the travel-related data from the network and analyze the travel-related data to identify a mode of travel of the mobile computing device. ... Massachusetts Institute Of Technology

07/16/15 / #20150196687

Compositions and uses to govern cancer cell growth

The invention relates to composition and a method of using the composition for modulting proliferation, invasiveness, the expression of a biomarker of an abnormal cell, of reducing the risk of patient cell becoming abnormal, or of modulating proliferation of a carcinoma-associated fibroblast or of a tumor-associated macrophage. The invention also relates to a method of culturing the composition to produce molecules that modulate abnormal cell proliferation, invasiveness, or metastasis. ... Massachusetts Institute Of Technology

07/16/15 / #20150196489

Polymer matrices for controlling crystallization

Compositions, methods, and systems for controlling crystallization of an agent are generally described. In some embodiments, an agent is crystallized in the presence of polymer matrices, such as polymer particles. ... Massachusetts Institute Of Technology

07/09/15 / #20150195430

Riesz pyramids for fast phase-based video magnification

Some embodiments are directed to a method, corresponding system, and corresponding apparatus for rendering a video and/or image display to amplify small motions through video magnification. Some embodiments include a new compact image pyramid representation, the riesz pyramid, that may be used for real-time, high-quality phase-based video magnification. ... Massachusetts Institute Of Technology

07/09/15 / #20150194818

Wireless energy transfer

Disclosed is an apparatus for use in wireless energy transfer, which includes a first resonator structure configured to transfer energy non-radiatively with a second resonator structure over a distance greater than a characteristic size of the second resonator structure. The non-radiative energy transfer is mediated by a coupling of a resonant field evanescent tail of the first resonator structure and a resonant field evanescent tail of the second resonator structure.. ... Massachusetts Institute Of Technology

07/09/15 / #20150192532

Methods and apparatus for optically detecting magnetic resonance

A light-trapping geometry enhances the sensitivity of strain, temperature, and/or electromagnetic field measurements using nitrogen vacancies in bulk diamond, which have exterior dimensions on the order of millimeters. In an example light-trapping geometry, a laser beam enters the bulk diamond, which may be at room temperature, through a facet or notch. ... Massachusetts Institute Of Technology

07/09/15 / #20150191359

Foams of graphene, method of making and materials made thereof

Method for making a liquid foam from graphene. The method includes preparing an aqueous dispersion of graphene oxide and adding a water miscible compound to the aqueous dispersion to produce a mixture including a modified form of graphene oxide. ... Massachusetts Institute Of Technology

07/09/15 / #20150190051

Temporal structured-illumination motion-detection system

The present invention provides devices and methods for detecting and tracking fast-moving-object. In one application, the present invention can be employed to detect and track fast eye movements (saccades). ... Massachusetts Institute Of Technology

07/02/15 / #20150188448

Apparatus for multi-level switched-capacitor rectification and dc-dc conversion

A voltage-step down rectifier topology suitable for integration on a die of an integrated circuit is described. In one embodiment, a switched capacitor rectifier is provided having an architecture such that an input voltage swing of the switched-capacitor rectifier is a factor n times an output voltage where n depends upon the number of stages such that the switched-capacitor rectifier can provide a π/(2n) step-down voltage conversion ratio between an input fundamental ac peak voltage to the output dc voltage. ... Massachusetts Institute Of Technology

07/02/15 / #20150188321

Wireless non-radiative energy transfer

Described herein are embodiments of a source high-q resonator, optionally coupled to an energy source, a second high-q resonator, optionally coupled to an energy drain that may be located a distance from the source resonator. A third high-q resonator, optionally coupled to an energy drain that may be located a distance from the source resonator. ... Massachusetts Institute Of Technology

07/02/15 / #20150184213

Engineering dna assembly in vivo and methods of making and using the reverse transcriptase technology

Cells that can synthesize oligonucleotides in vivo to produce a nucleic acid nanostructure are described. Methods for producing oligonucleotide nanostructures for use in regulating gene expression and altering biological pathways are provided. ... Massachusetts Institute Of Technology

07/02/15 / #20150183828

Self-assembling peptides incorporating modifications and methods of use thereof

The invention provides a self-assembling peptide comprising (a) a first amino acid domain that mediates self-assembly, wherein the domain comprises alternating hydrophobic and hydrophilic amino acids that are complementary and structurally compatible and self-assemble into a macroscopic structure when present in unmodified form; and (b) a second amino acid domain that does not self-assemble in isolated form. In certain embodiments of the invention the second amino acid domain comprises a biologically active peptide motif, e.g., a peptide motif found in a naturally occurring protein, or a target site for an interaction with a biomolecule. ... Massachusetts Institute Of Technology

07/02/15 / #20150182544

Modified saponins for the treatment of fungal infections

Methods of treating a fungal infection in a subject, the method comprising administering to the subject a modified saponin.. . ... Massachusetts Institute Of Technology

06/25/15 / #20150181559

Method for coding-based, delay-efficient data transmission

A method, apparatus and computer program product for -based, delay-efficient data transmission for broadcasting a single file is presented. A file (ƒ) comprised of k packets to be broadcast to a plurality of receivers is determined. ... Massachusetts Institute Of Technology

06/25/15 / #20150179321

Controlled liquid/solid mobility using external fields on lubricant-impregnated surfaces

A method for precise control of movement of a motive phase on a lubricant-impregnated surface includes providing a lubricant-impregnated surface, introducing the motive phase onto the lubricant-impregnated surface, and exposing the droplets to an electric and/or magnetic field to induce controlled movement of the droplets on the surface. The lubricant-impregnated surface includes a matrix of solid features spaced sufficiently close to stably contain the impregnating lubricant therebetween or therewithin. ... Massachusetts Institute Of Technology

06/25/15 / #20150179044

Wireless communication systems for underground pipe inspection

Wireless communication system for underground pipeline inspection. The system includes a plurality of sensor nodes moved by robots within the pipeline and each sensor node includes a radio transceiver. ... Massachusetts Institute Of Technology

06/25/15 / #20150177348

Biosensor, palm-sized device and method based on magnetic resonance relaxometry

In accordance with one aspect of this disclosure, there is provided a device for performing magnetic resonance relaxometry. The device comprises a radio-frequency spectrometer comprising at least one field-programmable gate array chip; a power amplifier electrically connected with the radio-frequency spectrometer and amplifying an electrical output of the radio-frequency spectrometer, thereby producing an amplified electrical signal comprising between about 0.1 watts and about 10 watts power; a duplexer configured to isolate the radio-frequency spectrometer from the amplified electrical signal during a receiving mode of the device; a radio-frequency detection probe configured to transmit radio-frequency electromagnetic radiation to excite nuclei under resonance during a transmission mode of the device, the radio-frequency detection probe comprising a detection coil comprising an inner diameter of less than about 1 millimeter; and at least one magnet supplying an external magnetic field to a detection region of the radio-frequency detection probe, the external magnetic field being less than about 3 tesla.. ... Massachusetts Institute Of Technology

06/25/15 / #20150177133

Tomographic phase microscopy

The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase-shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time-dependent changes in cell structure and the quantitative characterization of specimen-induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering.. ... Massachusetts Institute Of Technology

06/25/15 / #20150174549

High-throughput synthesis of nanoparticles

A simple and versatile coaxial turbulent jet mixer can synthesize a range of nanoparticles at high throughput, while maintaining the advantages of homogeneity, reproducibility, and tunability that are normally accessible only in specialized microscale mixing devices. Rapid mixing down to a timescale of 7 ms can be achieved by controlling the reynolds number, providing homogeneous and controllable environments for formation of nanoparticles, for example, by precipitation. ... Massachusetts Institute Of Technology

06/25/15 / #20150174265

Reversible masking of pore-forming proteins for macromolecular delivery

The present invention features compositions and methods for enhancing endosomal escape of therapeutic agents in the cytoplasm of a cell to thereby provide more effective therapy. The endocytic pathway is the major uptake mechanism of cells, and biological agents such as proteins, dna, and sirna become entrapped in endosomes and subsequently degraded by lysosomal enzymes. ... Massachusetts Institute Of Technology

06/25/15 / #20150174212

Identifying and modulating molecular pathways that mediate nervous system plasticity

The present invention provides methods for identifying genes and pathways involved in plasticity. The invention applies some of these methods to identify genes that are differentially regulated in at least a portion of the nervous system of an individual subjected to conditions known to result in altered nervous system plasticity, i.e., dark rearing (dr) or monocular deprivation (md). ... Massachusetts Institute Of Technology

06/25/15 / #20150174156

Controllably degradable compositions and methods

Methods for treating, adhering, or sealing biological tissue are provided. The methods include combining solutions containing a polymer component and a dendrimer component capable of reacting with each other, and at least one of the components includes a substituent capable of photoreversible dimerization that can be reversibly dimerized. ... Massachusetts Institute Of Technology

06/25/15 / #20150173918

Peripheral neural interface via nerve regeneration to distal tissues

At least partial function of a human limb is restored by surgically removing at least a portion of an injured or diseased human limb from a surgical site of an individual and transplanting a selected muscle into the remaining biological body of the individual, followed by contacting the transplanted selected muscle, or an associated nerve, with an electrode, to thereby control a device, such as a prosthetic limb, linked to the electrode. Simulating proprioceptive sensory feedback from a device includes mechanically linking at least one pair of agonist and antagonist muscles, wherein a nerve innervates each muscle, and supporting each pair with a support, whereby contraction of the agonist muscle of each pair will cause extension of the paired antagonist muscle. ... Massachusetts Institute Of Technology

06/18/15 / #20150171768

Inverter/power amplifier with capacitive energy transfer and related techniques

Circuit topologies and control methods for a dc-to-rf converter circuit are described.. . ... Massachusetts Institute Of Technology

06/18/15 / #20150170865

Method and apparatus for a porous electrospray emitter

An ionic liquid ion source can include a microfabricated body including a base and a tip. The body can be formed of a porous material compatible with at least one of an ionic liquid or room-temperature molten salt. ... Massachusetts Institute Of Technology

06/18/15 / #20150168217

Methods and apparatus for spectrometry

Multimode interference can be used to achieve ultra-high resolving powers (e.g., q>105) with linewidths down to 10 pm at 1500 nm and a broad spectroscopy range (e.g., 400-2400 nm) within a monolithic, millimeter-scale device. For instance, multimode interference (mmi) in a tapered waveguide enables fine resolution and broadband spectroscopy in a compact, monolithic device. ... Massachusetts Institute Of Technology

06/18/15 / #20150167959

Tunable nucleate boiling using electric fields and ionic surfactants

A tunable boiling system includes a fluid having a solvent and an ionic surfactant in the solvent, a counter electrode disposed within the fluid, and a working electrode having a surface in contact with the fluid. The system is configured to apply a voltage between the surface and the counter electrode in order to affect bubble formation in the fluid at the surface. ... Massachusetts Institute Of Technology

06/18/15 / #20150167034

Engineered microbes and methods for microbial oil production

Some aspects of this invention provide engineered microbes for oil production. Methods for microbe engineering and for use of engineered microbes are also provided herein. ... Massachusetts Institute Of Technology

06/18/15 / #20150166562

Methods and products related to protozoan disease

The invention relates to methods and related products for treatment or protozoan disease. The invention also relates to new compositions of matter useful in the treatment of protozoan disease and methods of identifying additional active compounds.. ... Massachusetts Institute Of Technology

06/18/15 / #20150165062

Translocation of non-natural chemical entities through anthrax protective antigen pore

Disclosed is a new approach for delivering compounds and drugs to the cytosol of living cells through the use of engineered protein transporters. The engineered protein transporters include a pore and a pore specific delivery protein, wherein a reagent such as a drug is attached to one or more of the engineered protein transporters.. ... Massachusetts Institute Of Technology

06/11/15 / #20150159452

Method and system for extending reach in deviated wellbores using selected vibration frequency

A method for extending reach of a coiled tubing string in a deviated wellbore includes determining a frequency of vibration of the tubing string based on a function of the bending resonance of the tubing string and vibrating the tubing string at the determined frequency while the tubing string is inside the wellbore. A non-transitory computer-readable storage medium to execute the foregoing method and a system for extending reach of a coiled tubing string in a deviated wellbore are also described.. ... Massachusetts Institute Of Technology

06/11/15 / #20150159447

Method and system for extending reach in deviated wellbores using selected injection speed

A method for extending reach of a coiled tubing string in a deviated wellbore includes vibrating the tubing string while the tubing string is injected into the wellbore at a first injection speed, finding the peak speed of lateral vibration of the tubing string, determining a second injection speed as a function of the obtained peak speed of lateral vibration, and adjusting the injection speed of the vibrating tubing string from the first injection speed to the determined second injection speed based on said function. A non-transitory computer-readable storage medium to execute the foregoing method is provided, along with a system for extending reach of a coiled tubing string in a deviated wellbore.. ... Massachusetts Institute Of Technology

06/11/15 / #20150158244

Object of additive manufacture with encoded predicted shape change and method of manufacturing same

The combination of 3d printing technology plus the additional dimension of transformation over time of the printed object is referred to herein as 4d printing technology. Particular arrangements of the additive manufacturing material(s) used in the 3d printing process can create a printed 3d object that transforms over time from a first, printed shape to a second, predetermined shape.. ... Massachusetts Institute Of Technology

06/11/15 / #20150158043

Discrete deposition of particles

A particle can be discretely ejected from a orifice.. . ... Massachusetts Institute Of Technology

06/04/15 / #20150156470

Reducing view transitions artifacts in automultiscopic displays

Automultiscopic displays enable glasses-free 3d viewing by providing both binocular and motion parallax. Within the display field of view, different images are observed depending on the viewing direction. ... Massachusetts Institute Of Technology

06/04/15 / #20150155585

Gravity induced flow cell

Gravity induced flow cell. The flow cell includes first and second reservoirs having a selected volume containing a flowable redox electrode. ... Massachusetts Institute Of Technology

06/04/15 / #20150153493

Device and method for luminescence enhancement by resonant energy transfer from an absorptive thin film

Disclosed are a device and a method for the design and fabrication of the device for enhancing the brightness of luminescent molecules, nanostructures, and thin films. The device includes a mirror, a dielectric medium or spacer, an absorptive layer, and a luminescent layer. ... Massachusetts Institute Of Technology

06/04/15 / #20150152134

Protein retrosplicing enabled by a double ligation reaction

Proteins containing a c-terminal thioester are important intermediates in semi-synthesis. Currently there is one main method for the synthesis of protein thioesters that relies upon the use of engineered inteins. ... Massachusetts Institute Of Technology

06/04/15 / #20150151980

Nanocrystal synthesis

A method of preparing monodisperse mx semiconductor nanocrystals can include contacting an m-containing precursor with an x donor to form a mixture, where the molar ratio between the m containing precursor and the x donor is large. Alternatively, if additional x donor is added during the reaction, a smaller ratio between the m containing precursor and the x donor can be used to prepare monodisperse mx semiconductor nanocrystals.. ... Massachusetts Institute Of Technology

06/04/15 / #20150150892

Methods and products related to lung cancer

The invention relates to methods and related products for treatment and determining modes of treatment for cancer. Preferably the methods relate to the inhibition of the nf-κb pathway in lung cancer.. ... Massachusetts Institute Of Technology

06/04/15 / #20150150714

Independent magnetically-multiplexed heating of portions of a target

A predetermined spatial locale is selectively operationally stimulated through local heating by exposing magnetic particle(s) associated with such local to alternating magnetic field parameters of which are chosen to generate hysteretic losses in magnetic particle(s). When different types of particles are associated with different locales such as different biological cells, different cells can be accessed and stimulated independently from one another. ... Massachusetts Institute Of Technology

05/28/15 / #20150148675

System and method for analyzing tissue using shear waves

A system and method for determining tissue changes. Shear waves are transmitted across the tissue in response to an ultrasonic signal input exterior to the tissue surface. ... Massachusetts Institute Of Technology

05/28/15 / #20150148655

System and method for non-contact ultrasound

A system and method for generating ultrasound images of a subject without physically contacting the subject is provided. A photoacoustic excitation source may be employed that directed into a scanning mirror to transmit acoustic disturbances into a patient to induce propagating photoacoustic waves. ... Massachusetts Institute Of Technology

05/28/15 / #20150148317

Spinal cord injury, inflammation, and immune-disease: local controlled release of therapeutic agents

A drug delivery system is provided for treatment of oxidative stress. The drug delivery system can include a therapeutic agent and a matrix. ... Massachusetts Institute Of Technology

05/28/15 / #20150147384

Sustained delivery of molecules using peptide surfactants and uses thereof

The present invention is directed to a drug delivery composition comprising a self-assembled nanostructure and biologically active molecule, wherein the nanostructure comprises surfactant peptides, and wherein the biologically active molecule is encapsulated in the nanostructure. The invention also encompasses methods of administering a biologically active molecule to a subject comprising administering the drug delivery composition and methods for the preparation of said composition.. ... Massachusetts Institute Of Technology

05/28/15 / #20150147329

Influenza treatment and/or characterization, human-adapted ha polypeptides; vaccines

The present invention provides, among other things, methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza infections.. . ... Massachusetts Institute Of Technology

05/28/15 / #20150145741

Wideband simultaneous transmit and receive (star) antenna with miniaturized tem horn elements

An antenna system capable of achieving simultaneous transmit and receive (star.) operation over a wide bandwidth includes a ring array of tem horn elements and a centrally located monocone or bicone antenna. The tem horn elements each include a capacitive feed. ... Massachusetts Institute Of Technology

05/28/15 / #20150144259

Quick-release adhesive tapes

Methods and compositions for securing to and removing adhesive tapes from substrates, e.g., delicate substrates such as skin, are described. The methods include providing an adhesive tape comprising an adhesive layer and a support layer in contact with the adhesive layer. ... Massachusetts Institute Of Technology

05/28/15 / #20150144176

Photovoltaic power balancing and differential power processing

Power production among photovoltaic elements can be equalized through charge redistribution, which can reduce or eliminate the effect of partial shading. Also described is a technique for differential power processing by individually setting currents through different strings of photovoltaic elements.. ... Massachusetts Institute Of Technology

05/21/15 / #20150142966

Signal-flow architecture for cooperative control and resource allocation

. . Methods and supporting systems for allocating a resource among multiple agents are disclosed. Multipoint-to-multipoint communication is established among the agents, with each agent using an amount of a resource. ... Massachusetts Institute Of Technology

05/21/15 / #20150141756

Continuum style manipulator actuated with phase change media

A continuum style manipulator is actuated by jammable media within an envelope of a module, which is also actuated by a tensile element, such as a cable and spooler motor. Multiple modules may be reversibly added. ... Massachusetts Institute Of Technology

05/21/15 / #20150141684

Nickel pre-catalysts and related compositions and methods

Described herein are nickel pre-catalysts and related compositions and methods. The nickel pre-catalysts may be activated to form catalysts which may be utilized in organic reactions.. ... Massachusetts Institute Of Technology

05/21/15 / #20150141263

Massively parallel combinatorial genetics

The invention relates to methods and compositions that enable the rapid generation of high-order combinations of genetic elements, and that provide a barcoded basis for rapid characterization of the specific combination of genetic elements encoded within a single cell or in a pooled population.. . ... Massachusetts Institute Of Technology

05/21/15 / #20150137712

Multi-actuator design and control for a high-speed/large-range nanopositioning system

Multi-actuator system. The system includes at least two nano positioners having different ranges and bandwidths located in cascaded serial form to contact and move an object. ... Massachusetts Institute Of Technology

05/07/15 / #20150127117

Active ankle foot orthosis

An active ankle foot orthosis (aafo) is provided where the impedance of an orthotic joint is modulated throughout the walking cycle to treat ankle foot gait pathology, such as drop foot gait. During controlled plantar flexion, a biomimetic torsional spring control is applied where orthotic joint stiffness is actively adjusted to minimize forefoot collisions with the ground. ... Massachusetts Institute Of Technology

05/07/15 / #20150127085

Endovascular devices with axial perturbations

Endovascular devices are provided. The endovascular devices include a conformable scaffold with one or more outpocketings. ... Massachusetts Institute Of Technology

05/07/15 / #20150126496

Diagnosis and treatment of autism spectrum disorders

The invention relates to methods for diagnosis and treatment of autism spectrum disorders, particularly for autism spectrum disorders characterized by increased head size (circumference) and deficits in social behavior.. . ... Massachusetts Institute Of Technology

05/07/15 / #20150126412

Systems for filling a sample array by droplet dragging

A method and an array filling system for loading a plurality of disparate sample containers, the sample containers comprising an integral structure. Each receptacle is characterized by a hydrophilic surface, and the receptacles are separated by a hydrophobic surface. ... Massachusetts Institute Of Technology

05/07/15 / #20150125904

Probe incorporation mediated by enzymes

Compositions (e.g., lipoic acid ligase polypeptides and lipoic acid analogs) and uses thereof in the probe incorporation mediated by enzymes (prime) methods both in vitro and in vivo. Also described herein are kits for performing the prime method and vectors/kits for expressing the lipoic acid ligases.. ... Massachusetts Institute Of Technology

05/07/15 / #20150125879

Biodegradable layer-by-layer (lbl) films for cell capture and release

Compositions and methods for providing devices comprised of a substrate and a layer-by-layer (lbl) film coated on at least a surface of the substrate, which lbl film comprises binding agents that specifically interact with cells. Such devices are useful, for example, in various cell isolation applications. ... Massachusetts Institute Of Technology

05/07/15 / #20150125764

Flow battery using non-newtonian fluids

Flow battery. The battery includes high energy density fluid electrodes having a selected non-newtonian rheology and structure for providing intermittent flow pulses of controlled volume and duration of the fluid electrodes, the structure adapted to promote interfacial slip to improve flow uniformity. ... Massachusetts Institute Of Technology

05/07/15 / #20150125391

Bone and metal targeted polymeric nanoparticles

In certain embodiments, the invention relates to an article having a liquid-impregnated surface. The surface includes a matrix of solid features (e.g., non-toxic and/or edible features) spaced sufficiently close to stably contain a liquid therebetween or therewithin, wherein the liquid is non-toxic and/or edible. Bone- and metal-targeted polymeric nanoparticles are provided. Exemplary nanoparticles have three main components: 1) a targeting element that can selectively bind to bone, minerals, or metal ions; 2) a layer of stealth to allow the polymer to evade immune response; and 3) a biodegradable polymeric material, forming an inner core which can carry therapeutics or other diagnostics. ... Massachusetts Institute Of Technology

05/07/15 / #20150125338

Stable binary nanocrystalline alloys and methods of identifying same

Identifying a stable phase of a binary alloy comprising a solute element and a solvent element. In one example, at least two thermodynamic parameters associated with grain growth and phase separation of the binary alloy are determined, and the stable phase of the binary alloy is identified based on the first thermodynamic parameter and the second thermodynamic parameter, wherein the stable phase is one of a stable nanocrystalline phase, a metastable nanocrystalline phase, and a non-nanocrystalline phase.. ... Massachusetts Institute Of Technology

05/07/15 / #20150125111

Waveguide formation using cmos fabrication techniques

Conventional approaches to integrating waveguides within standard electronic processes typically involve using a dielectric layer, such as polysilicon, single-crystalline silicon, or silicon nitride, within the in-foundry process or depositing and patterning a dielectric layer in the backend as a post-foundry process. In the present approach, the back-end of the silicon handle is etched away after in-foundry processing to expose voids or trenches defined using standard in-foundry processing (e.g., complementary metal-oxide-semiconductor (cmos) processing). ... Massachusetts Institute Of Technology

05/07/15 / #20150124907

Hardware-efficient signal-component separator for outphasing power amplifiers

Described herein is a fixed-point piece-wise linear (fp pwl) approximation technique for computations of nonlinear functions. The technique results in circuit designs having relatively few and simple arithmetic operations, short arithmetic operands and small-sized look-up tables and the circuits resultant there from can be efficiently pipelined to run at multi-gsamples/s throughputs. ... Massachusetts Institute Of Technology

05/07/15 / #20150124062

Joint view expansion and filtering for automultiscopic 3d displays

Multi-view autostereoscopic displays provide an immersive, glasses-free 3d viewing experience, but they preferably use correctly filtered content from multiple viewpoints. The filtered content, however, may not be easily obtained with current stereoscopic production pipelines. ... Massachusetts Institute Of Technology

05/07/15 / #20150123831

Digital readout method and apparatus

Autonomously operating analog to digital converters are formed into a two dimensional array. The array may incorporate digital signal processing functionality. ... Massachusetts Institute Of Technology

05/07/15 / #20150122735

Membrane for filtrating water

The present invention relates to a material. In particular, it relates to a membrane for filtering water. ... Massachusetts Institute Of Technology

05/07/15 / #20150122338

Automated method for simultaneous bubble detection and expulsion

A method and apparatus for detecting and removing air from a syringe containing a volume of liquid and a volume of gas is described. The method includes moving a piston in the syringe to expel gas through an orifice of the syringe, sensing a movement of the piston in the syringe, and determining when the volume of gas is expelled from the syringe based on a change in the sensed movement. ... Massachusetts Institute Of Technology

04/30/15 / #20150120241

Methods and apparatus for coded time-of-flight camera

In illustrative implementations, a time-of-flight camera robustly measures scene depths, despite multipath interference. The camera emits amplitude modulated light. ... Massachusetts Institute Of Technology

04/30/15 / #20150119286

High-throughput corrosion testing platform

A high-throughput corrosion testing mechanism was developed for metals in a variety of environments in controlled, multiplexed microenvironments. Many parallel experiments can be conducted with microbial and environmental variables independently manipulated to identify the key determinants of corrosion progression. ... Massachusetts Institute Of Technology

04/30/15 / #20150119280

Hydrogel microstructures with immiscible fluid isolation for small reaction volumes

Techniques for hydrogel microstructures with oil isolation for small reaction volumes include providing a hydrogel microstructure that has a plurality of pores and a hydrogel frame surrounding the pores. The microstructure has a volume in a range from about 1 picoliter to about 10,000 picoliters and is configured to repel an immiscible fluid. ... Massachusetts Institute Of Technology

04/30/15 / #20150118712

Cell-directed synthesis of multifunctional nanopatterns and nanomaterials

Aspects of the invention relate to the engineering of biological nanostructures and materials.. . ... Massachusetts Institute Of Technology

04/30/15 / #20150116887

Method and apparatus for producing an asymmetric magnetic field

A system for generating an asymmetric magnetic field. The system includes a drive circuit and a stacked winding structure coupled to the drive circuit. ... Massachusetts Institute Of Technology

04/30/15 / #20150116093

Chemical and physical sensing with a reader and rfid tags

A method of detecting a stimulus can include detecting an output from a radio frequency identification tag including a sensor. A smartphone-based sensing strategy can use chemiresponsive nanomaterials integrated into the circuitry of commercial near field communication tags to achieve non-line-of-sight, portable, and inexpensive detection and discrimination of gas phase chemicals (e.g., ammonia, hydrogen peroxide, cyclohexanone, and water) at part-per-thousand and part-per-million concentrations.. ... Massachusetts Institute Of Technology

04/23/15 / #20150112261

Methods and devices for sensing tissues and tissue compartments

An apparatus provides feedback regarding the material in which tip of the apparatus is located as the tip is advanced into matter of varying resistances. The apparatus responds to a change in pressure, force, or other parameter such that when the tip reaches matter of a certain resistance, a change in the parameter is sensed. ... Massachusetts Institute Of Technology

04/23/15 / #20150112232

Using correlation structure of speech dynamics to detect neurological changes

A method and a system for assessing a condition in a subject. An example of a condition is a major depressive disorder (mdd). ... Massachusetts Institute Of Technology

04/23/15 / #20150111063

Hydrophobic materials incorporating rare earth elements and methods of manufacture

This invention relates generally to an article that includes a base substrate, an intermediate layer including at least one element or compound selected from titanium, chromium, indium, zirconium, tungsten, and titanium nitride on the base substrate, and a hydrophobic coating on the base substrate, wherein the hydrophobic coating includes a rare earth element material (e.g., a rare earth oxide, a rare earth carbide, a rare earth nitride, a rare earth fluoride, and/or a rare earth boride). An exposed surface of the hydrophobic coating has a dynamic contact angle with water of at least about 90 degrees. ... Massachusetts Institute Of Technology

04/23/15 / #20150110825

Self-assembled nanoparticle vaccines

The present invention provides nanoparticles and compositions of various constructs that combine meta-stable viral proteins (e.g., rsv f protein) and self-assembling molecules (e.g., ferritin, hsps) such that the pre-fusion conformational state of these key viral proteins is preserved (and locked) along with the protein self-assembling into a polyhedral shape, thereby creating nanoparticles that are effective vaccine agents. The invention also provides nanoparticles comprising a viral fusion protein, or fragment or variant thereof, and a self-assembling molecule, and immunogenic and vaccine compositions including the same.. ... Massachusetts Institute Of Technology

04/23/15 / #20150110740

Carrier-free biologically-active protein nanostructures

The present disclosure provides compositions and methods for efficient and effective protein delivery in vitro and in vivo. In some aspects, proteins are reversibly crosslinked to each other and/or modified with functional groups and protected from protease degradation by a polymer-based or silica-based nanoshell.. ... Massachusetts Institute Of Technology

04/23/15 / #20150110696

Reversible sorbent for warm co2 capture by pressure swing adsorption

Sorbent for reversible warm co2 capture. The sorbent includes activated carbon impregnated with magnesium oxide, wherein the magnesium oxide constitutes at least 5% by weight of the sorbent.. ... Massachusetts Institute Of Technology

04/23/15 / #20150110694

Methods and systems for carrying out a ph-influenced chemical and/or biological reaction

The present invention generally relates to methods and systems for carrying out a ph-influenced chemical and/or biological reaction. In some embodiments, the ph-influenced reaction involves the conversion of co2 to a dissolved species.. ... Massachusetts Institute Of Technology

04/23/15 / #20150107334

Continuous measurement chromatography and method of continuous stochastic perturbation chromatography

A method and system for continuous measurement chromatograph involves stochastically modulating a system variable. The sample can be introduced into a chromatography column. ... Massachusetts Institute Of Technology

04/23/15 / #20150107233

Methods and apparatus for layer jamming

In some implementations, bending or other shape changes of a device are actuated by inflating or deflating a bladder in the device. Then, once the desired new shape is achieved by this actuation, another bladder in the device is layer-jammed, to make the device rigid in the new shape. ... Massachusetts Institute Of Technology

04/16/15 / #20150105337

Enterobactin conjugates and uses thereof

The present invention provides novel enterobactin-cargo conjugates, such as compounds of formula (i), and salts thereof, where x is the cargo and may be an antibiotic, a fluorophore, or biotin. The present invention also provides complexes, compositions, kits, and methods that involve the compounds of formula (i) and are useful in delivering a cargo to a bacterium, treating a bacterial infection, cystic fibrosis, and/or inflammatory bowel disease in a subject, preventing a bacterial infection, cystic fibrosis, and/or inflammatory bowel disease in a subject, inhibiting the growth of or killing a bacterium, or determining the concentration of a bacterium in a biological sample. ... Massachusetts Institute Of Technology

04/16/15 / #20150105241

Process for the production of non-sintered transition metal carbide and nitride nanoparticles

Transition metal carbide, nitride, phosphide, sulfide, or boride nanoparticles can be made by transforming metal oxide materials coated in a ceramic material in a controlled environment. The coating prevents sintering while allowing the diffusion of reactive gases through the inorganic matrix that can then alter the metal nanoparticle oxidation state, remove oxygen, or intercalate into the lattice to form a carbide, nitride, phosphide, sulfide, or boride.. ... Massachusetts Institute Of Technology

04/16/15 / #20150104515

Particles for inhalation having sustained release properties

The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. ... Massachusetts Institute Of Technology

04/09/15 / #20150099328

Monolithic integration of cmos and non-silicon devices

A method includes attaching a partially processed cmos wafer to a second wafer to produce a combined wafer. The second wafer comprises a first region including a material different from silicon. ... Massachusetts Institute Of Technology

04/09/15 / #20150099199

Battery with heterogeneous flow-through porous electrodes

The invention discloses general apparatus and methods for electrochemical energy conversion and storage via a membraneless laminar flow battery. In a preferred embodiment, the battery includes a flow-through porous anode for receiving a fuel and a porous electrolyte channel for transporting an electrolyte adjacent to the porous anode; a flow-through porous cathode is provided for transporting an oxidant; and a porous dispersion blocker is disposed between the electrolyte channel and the porous cathode, which inhibits convective mixing while allowing molecular diffusion and mean flow. ... Massachusetts Institute Of Technology

04/09/15 / #20150099001

Nanocell drug delivery system

Nanocells allow the sequential delivery of two different therapeutic agents with different modes of action or different pharmacokinetics. A nanocell is formed by encapsulating a nanocore with a first agent inside a lipid vesicle containing a second agent. ... Massachusetts Institute Of Technology

04/02/15 / #20150095841

Systems and methods for composable analytics

Systems, methods, and computer readable medium are provided for a composable analytics environment. A graphical module repository is provided that consists of a plurality of graphical modules that are configured to perform a data processing function. ... Massachusetts Institute Of Technology

04/02/15 / #20150094255

Lectin conjugates for mucin hydration

The invention provides, inter alia, conjugates of a hydratable polymer (such as peg, polyethylene glycol) and a lectin (such as wheat germ agglutinin, wga), compositions comprising these conjugates, as well as methods and targeted uses of these conjugates and compositions for, e.g., lubricating, maintaining hydration of rehydrating, and/or inhibiting microorganism colonization of a biological surface in need thereof.. . ... Massachusetts Institute Of Technology

04/02/15 / #20150093794

Cellular production of glucaric acid

The invention relates to the production of glucuronic and glucaric acid in cells through recombinant expression of myo-inositol 1-phosphate synthase, myo-inositol oxygenase and uronate dehydrogenase. Cloning and characterization of the gene encoding uronate dehydrogenase is also disclosed.. ... Massachusetts Institute Of Technology

04/02/15 / #20150093745

Optoelectronic detection system

The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.. ... Massachusetts Institute Of Technology

04/02/15 / #20150091061

Passivation technique for wide bandgap semiconductor devices

A method of protecting a semiconductor structure from water and a semiconductor structure formed by the method. The semiconductor structure includes a wide-bandgap semiconductor material in which at least one semiconductor device is formed. ... Massachusetts Institute Of Technology

03/26/15 / #20150087991

Application specific integrated circuit with column-row-parallel architecture for ultrasonic imaging

An ultrasonic imaging system is described in which a column-row-parallel architecture is provided at the circuit level of an ultrasonic transceiver. The ultrasonic imaging system can include a n×m array of transducer elements and a plurality of transceiver circuits where each transceiver circuit is connected to a corresponding one transducer element of the n×m array of transducer elements. ... Massachusetts Institute Of Technology

03/26/15 / #20150087055

Analog and mixed-signal computation and circuits in living cells

Provided herein are molecular analog gene circuits that exploit positive and negative feedback to implement logarithmically linear sensing, addition, subtraction, and scaling thus enabling multiplicative, ratiometric, and power-law computations. The circuits exhibit weber's law behavior as in natural biological systems, operate over a wide dynamic range of up to four orders of magnitude, and can be architected to have tunable transfer functions. ... Massachusetts Institute Of Technology

03/26/15 / #20150086668

Extruder feed system

Extruder feed system. The system includes a pair of spaced-apart, internally and oppositely threaded rotatable elements for receiving and engaging a plastic filament material. ... Massachusetts Institute Of Technology

03/26/15 / #20150086599

Self assembled films for protein and drug delivery applications

Provided are systems for controlled release of proteins from decomposable thin films constructed by layer-by-layer deposition. Such films generally comprise alternating layers of polymers and proteins, and may further comprise additional layers of polyions. ... Massachusetts Institute Of Technology

03/26/15 / #20150086516

Methods, compositions, and devices to induce mobilization and recruitment of progenitor cells

Methods, compositions and systems are provided for mobilizing and recruiting progenitor, progenitor-like cells, and/or stem cells to a target site, such as an in vivo site in a patient in need of treatment. In embodiments, the methods include embedding cells in a matrix material having a three-dimensional structure capable of contacting the cells in a non-planar manner to alter the secretome of the cells and/or mirna expression in a manner effective to recruit progenitor, progenitor-like, or stem cells.. ... Massachusetts Institute Of Technology

03/26/15 / #20150083032

Combustion system

Combustion system. The system includes a combustor generating a combustion gas and a splitter for receiving the combustion gas and dividing the combustion gas into first and second gas streams. ... Massachusetts Institute Of Technology

03/26/15 / #20150082582

Methods and apparatus for robotic zipper

A robotic zipper system for joining and separating zipper halves of a zipper tape. A chassis retains an actuator that drives a zipper slide geometry along the zipper tape to join or separate the zipper tape. ... Massachusetts Institute Of Technology

03/19/15 / #20150082468

Inverse patterning process for three-dimensional multi-compartmental micro-organization of multiple cell types

The invention features an “inverse patterning” or “intaglio-void/embed-relief topographic (in vert) molding” manufacturing process for generating high-resolution three-dimensional (3d) multi-cellular microstructures in distinct cellular compartments of a single hydrogel. The platform has general utility in the development of engineered tissues for human therapies, drug testing, and disease models. ... Massachusetts Institute Of Technology

03/19/15 / #20150080234

Cell patterning

The present disclosure provides technologies for achieving cell patterning, as well as patterned cell arrays achieved with such technologies. Provided apparatus and methods are useful in a variety of contexts and provide particular advantages with respect to assessing living cell arrays and/or their responsiveness to stimuli, including identifying and/or characterizing complex cellular responses.. ... Massachusetts Institute Of Technology

03/19/15 / #20150079681

Crispr-cas component systems, methods and compositions for sequence manipulation

The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a crispr complex, as well as methods for the design and use of such vectors. ... Massachusetts Institute Of Technology

03/19/15 / #20150079645

Microbial engineering for the production of fatty acids and fatty acid derivatives

Some aspects of this invention relate to methods useful for the conversion of a carbon source to a biofuel or biofuel precursor using engineered microbes. Some aspects of this invention relate to the discovery of a key regulator of lipid metabolism in microbes. ... Massachusetts Institute Of Technology

03/19/15 / #20150079282

Conductive polymer films grafted on organic substrates

One aspect of the invention relates to a linker-free, one-step method of grafting polymer films onto organic substrates, and the films obtained by such a method. In certain embodiments, the grafted polymer films are conductive. ... Massachusetts Institute Of Technology

03/19/15 / #20150079113

Mena and alpha5 integrin interaction

Methods are provided for treating invasion of a tumor or metastasis of a tumor in a subject comprising administering to the subject an agent which inhibits the interaction of mena with an alpha5 integrin. Assays for identifying agents that inhibit interaction of mena with an alpha5 integrin are also provided.. ... Massachusetts Institute Of Technology

03/19/15 / #20150075989

Devices and methods using porous membranes for oil-water emulsion separation

The invention provides methods and devices that use membranes to separate oil/water mixtures. The methods and devices have a wide range of applications, including deep seep oil exploration, oil purification, and oil spill cleanup. ... Massachusetts Institute Of Technology

03/12/15 / #20150073319

Controllable compression textiles using shape memory alloys and associated products

An active compression garment includes at least one active textile member formed from a shape memory alloy (sma) material to provide controllable compression to a body part of interest. The active compression garment may also include at least one contact for applying an electrical stimulus signal to the active textile member to cause the sma material to return to a trained shape.. ... Massachusetts Institute Of Technology

03/12/15 / #20150073318

Controllable compression garments using shape memory alloys and associated techniques and structures

An active compression garment includes at least one passive member to at least partially surround a body part of interest and at least one active actuator member including a shape memory alloy (sma) that is coupled to the at least one passive member. The at least one active actuator member may be configured to apply compression to, or remove compression from, the body part of interest based on the presence or absence of an applied stimulus.. ... Massachusetts Institute Of Technology

03/12/15 / #20150072133

Localized solar collectors

A localized heating structure, and method of forming same, for use in solar systems includes a thermally insulating layer having interconnected pores, a density of less than about 3000 kg/m3, and a hydrophilic surface, and an expanded carbon structure adjacent to the thermally insulating layer. The expanded carbon structure has a porosity of greater than about 80% and a hydrophilic surface.. ... Massachusetts Institute Of Technology

03/12/15 / #20150071849

Systems and methods related to the formation of carbon-based nanostructures

Systems and methods for the formation of carbon-based nanostructures are generally described. In some embodiments, the nanostructures may be formed on a nanopositor. ... Massachusetts Institute Of Technology

03/12/15 / #20150068599

Metallic dielectric photonic crystals and methods of fabrication

A metallic-dielectric photonic crystal is formed with a periodic structure defining a plurality of resonant cavities to selectively absorb incident radiation. A metal layer is deposited on the inner surfaces of the resonant cavities and a dielectric material fills inside the resonant cavities. ... Massachusetts Institute Of Technology

03/12/15 / #20150068335

Methods and apparatus for selective rod actuation

In exemplary implementations, a target rod is actuated. The target rod is part of a set of threaded, elongated rods, the longitudinal axes of which are substantially parallel to each other. ... Massachusetts Institute Of Technology

03/05/15 / #20150066440

System and method for designing three-dimensional objects

According to some aspects, a method of designing an object based on a three-dimensional model representing a shape of the object is provided. The object may be fabricated from a plurality of materials having one or more known physical properties, wherein the object is designed to exhibit one or more target properties. ... Massachusetts Institute Of Technology

03/05/15 / #20150066152

Orthopaedic joints providing enhanced lubricity

The present disclosure provides, among other things, prosthetic joint components having textured surface(s) for improving lubrication and increasing the useful life of the prosthetic joint components. The textured surface includes solid features configured to stably contain a biological fluid or a synthetic biological fluid therebetween or therewithin for a non-zero residence time.. ... Massachusetts Institute Of Technology

03/05/15 / #20150065723

Olefin metathesis catalysts and related methods

The present invention provides methods for the synthesis of catalysts and precursors thereof. Methods of the invention may comprise combining a catalyst precursor and at least one ligand to generate a catalytically active species, often under mild conditions and in high yields. ... Massachusetts Institute Of Technology

03/05/15 / #20150065389

Multi-well micropatterning by ablation

The present invention is drawn to the generation of micropatterns of biomolecules and cells on standard laboratory materials through selective ablation of a physisorbed biomolecule with oxygen plasma. In certain embodiments, oxygen plasma is able to ablate selectively physisorbed layers of biomolecules (e.g., type-i collagen, fibronectin, laminin, and matrigel) along complex non-linear paths which are difficult or impossible to pattern using alternative methods. ... Massachusetts Institute Of Technology

03/05/15 / #20150064791

Microfluidic-based gene synthesis

A method for synthesizing long dna constructs from oligonucleotide precursors directly within a microfluidic device uses several oligonucleotides at once. A precursor mix containing at least two oligonucleotide precursors with at least partial base complementarity is introduced into an input of a microfluidic chip and at least one cycle of at least one gene synthesis protocol is applied to fabricate a dna construct containing the sequence of at least two oligonucleotide precursors. ... Massachusetts Institute Of Technology

03/05/15 / #20150064770

Tuning bacteriophage host range

Various aspects and embodiments of the invention are directed to high-throughput phage-engineering methods and recombinant bacteriophages with tunable host ranges for controlling phage specificity.. . ... Massachusetts Institute Of Technology

03/05/15 / #20150064471

Seed for metal dichalcogenide growth by chemical vapor deposition

A metal dichalcogenide layer is produced on a transfer substrate by seeding f16cupc molecules on a surface of a growth substrate, growing a layer (e.g., a monolayer) of a metal dichalcogenide via chemical vapor deposition on the growth substrate surface seeded with f16cupc molecules, and contacting the f16cupc-molecule and metal-dichalcogenide coated growth substrate with a composition that releases the metal dichalcogenide from the growth substrate.. . ... Massachusetts Institute Of Technology

03/05/15 / #20150064138

Tuning microbial populations with programmable nucleases

Various aspects and embodiments of the invention are directed to methods and compositions for reversing antibiotic resistance or virulence in and/or destroying pathogenic microbial cells such as, for example, pathogenic bacterial cells. The methods include exposing microbial cells to a delivery vehicle with at least one nucleic acid encoding an engineered autonomously distributed circuit that contains a programmable nuclease targeted to one or multiple genes of interest.. ... Massachusetts Institute Of Technology

02/26/15 / #20150057315

Methods for treatment of 16p11.2 microdeletion syndrome

Subjects that have a 16p11.2 microdeletion syndrome are treated by administering compositions that include mglur inhibitors, including mglur antagonists that include mglur negative allosteric modulators. Administration of compositions employed in the methods of the invention can treat psychiatric, including neuropsychiatric disorders, cognitive impairments, attention, obesity, intellectual disability and seizure disorders.. ... Massachusetts Institute Of Technology

02/26/15 / #20150053337

Carrier-substrate adhesive system

A system and method for creating three-dimensional nanostructures is disclosed. The system includes a substrate bonded to a carrier using a bonding agent. ... Massachusetts Institute Of Technology

02/26/15 / #20150053266

Internally-heated thermal and externally-cool photovoltaic cascade solar energy system for full solar spectrum utilization

A single-stack, solar power receiver comprising both a thermal absorber layer and a photovoltaic cell layer. The stack includes an aerogel layer, that is optically transparent and thermally insulating (“otti”); a spectrally selective high thermal conductivity (“sstc”) thermal absorber layer; a bottom otti layer; and a pv cell layer. ... Massachusetts Institute Of Technology

02/19/15 / #20150051710

Model-based neuromechanical controller for a robotic leg

A model-based neuromechanical controller for a robotic limb having at least one joint includes a finite state machine configured to receive feedback data relating to the state of the robotic limb and to determine the state of the robotic limb, a muscle model processor configured to receive state information from the finite state machine and, using muscle geometry and reflex architecture information and a neuromuscular model, to determine at least one desired joint torque or stiffness command to be sent to the robotic limb, and a joint command processor configured to command the biomimetic torques and stiffnesses determined by the muscle model processor at the robotic limb joint. The feedback data is preferably provided by at least one sensor mounted at each joint of the robotic limb. ... Massachusetts Institute Of Technology

02/19/15 / #20150051513

Nonlinear system identification techniques and devices for discovering dynamic and static tissue properties

A device for measuring a mechanical property of a tissue includes a probe configured to perturb the tissue with movement relative to a surface of the tissue, an actuator coupled to the probe to move the probe, a detector configured to measure a response of the tissue to the perturbation, and a controller coupled to the actuator and the detector. The controller drives the actuator using a stochastic sequence and determines the mechanical property of the tissue using the measured response received from the detector. ... Massachusetts Institute Of Technology

02/19/15 / #20150051139

Mucins as antiviral compounds

The invention provides methods, and compositions for performing the methods, that reduce the diffusion or overall mobility of a virus on a surface, such as a biological surface using a purified mucin. The methods can reduce the infectivity of a virus for a cell on the surface. ... Massachusetts Institute Of Technology

02/19/15 / #20150050723

Optoelectronic detection system

The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. ... Massachusetts Institute Of Technology

02/19/15 / #20150049210

Method and apparatus for motion coded imaging

An imaging apparatus and corresponding method according to an embodiment of the present invention enables high-resolution, wide-field-of-view, high sensitivity imaging. An embodiment of the invention is a camera system that utilizes motion of an optical element, such as a spatial filtering mask or of the camera itself, to apply different spatial filtering functions to a scene to be imaged. ... Massachusetts Institute Of Technology

02/19/15 / #20150048676

Wireless non-radiative energy transfer

Described herein are embodiments of a source high-q resonator, optionally coupled to an energy source, a second high-q resonator, optionally coupled to an energy drain that may be located a distance from the source resonator. A third high-q resonator, optionally coupled to an energy drain that may be located a distance from the source resonator. ... Massachusetts Institute Of Technology

02/12/15 / #20150047074

Nanobionic engineering of organelles and photosynthetic organisms

In one aspect, a composition can include an organelle, and a nanoparticle having a zeta potential of less than −10 mv or greater than 10 mv contained within the organelle. In a preferred embodiment, the organelle can be a chloroplast and the nanoparticle can be a single-walled carbon nanotube associated with a strongly anionic or strongly cationic polymer.. ... Massachusetts Institute Of Technology

02/12/15 / #20150045928

Automatic process control of additive manufacturing device

Automatic process control of additive manufacturing. The system includes an additive manufacturing device for making an object and a local network computer controlling the device. ... Massachusetts Institute Of Technology

02/12/15 / #20150045570

Phosphine-ligated palladium sulfonate palladacycles

Described are palladium precatalysts, and methods of making and using them. The palladium precatalysts show improved stability and improved reactivity in comparison to previously-described palladium precatalysts.. ... Massachusetts Institute Of Technology

02/12/15 / #20150045537

Extracellular release of lipids by photosynthetic cells

The invention relates to methods for harvesting macromolecules such as lipids and proteins by culturing in growth medium a photo synthetic cyanobacteria that secretes vesicles into the growth medium, and separating the secreted vesicles from the cyanobacteria and/or from the growth medium.. . ... Massachusetts Institute Of Technology

02/12/15 / #20150045259

High-throughput platform for in-vivo sub-cellular screens on vertebrate larvae

High throughput system for in vivo screens on vertebrate larvae. The system includes a source of vertebrate larvae in a liquid medium and loading tube means for aspirating a larva. ... Massachusetts Institute Of Technology

02/12/15 / #20150044463

Dynamic in-fiber particle production with precise dimensional control

A fiber is provided that has been thermally drawn from a fiber preform, having a longitudinal-axis length and including at least one core that has a longitudinal core axis parallel to the longitudinal axis and internally disposed to at least one outer fiber cladding material layer along the fiber length. The fiber is fed through a localized heating site having a heating site temperature, t, that is above a melting temperature of the fiber core, with a feed speed, υf, that melts a portion of the fiber core at the heating site, causing molten droplets to pinch off of fiber core material, one droplet at a time, with a time period of molten droplet formation set by the fiber feed speed, υf. ... Massachusetts Institute Of Technology

02/05/15 / #20150038870

Multi-channel scalable eeg acquisition system on a chip with integrated patient specific seizure classification and recording processor

An integrated circuit chip and method for eeg monitoring. In one embodiment, the integrated circuit chip includes an analog front end cell in communication with an electrode and a classification processor wherein a signal received from the electrode is processed by the classification engine cell and designated as seizure or non-seizure. ... Massachusetts Institute Of Technology

02/05/15 / #20150037829

Cytosolically-active peroxidases as reporters for microscopy

An imaging method comprising expressing in cells a class i heme peroxidase, which optionally is fused with a protein of interest or a cellular localization signal peptide, and contacting the cells with a substrate of the class i heme peroxidase to allow conversion of the substrate into a product via an oxidation reaction catalyzed by the class i heme peroxidase, wherein the product releases a signal detectable by a microscope such as an electron microscope. Also disclosed herein are monomeric mutants of a class i heme peroxidase and mutants of the enzyme that exhibit elevated enzymatic activity as compared to the corresponding wild-type counterpart.. ... Massachusetts Institute Of Technology

02/05/15 / #20150035880

Methods and apparatus for visual display

In exemplary implementations of this invention, light from a backlight is transmitted through two stacked lcds and then through a diffuser. The front side of the diffuser displays a time-varying sequence of 2d images. ... Massachusetts Institute Of Technology

01/29/15 / #20150032190

Methods and apparatus for omnidirectional tissue illumination

Embodiments of the present invention include a fiber-optic tissue illuminator suitable for illuminating large areas of central and peripheral neural tissue, e.g., in a primate brain. Certain examples of the tissue illuminator have a light delivery surface that may be about two orders of magnitude larger than that of a conventional optical fiber of equal diameter. ... Massachusetts Institute Of Technology

01/29/15 / #20150031138

Emissive compositions with internal standard and related techniques

The present invention provides materials, devices, and methods related to determination of an analyte. In some embodiments, an analyte may be determined by monitoring, for example, a change in an optical signal of a luminescent material (e.g., particle) upon exposure to an analyte. ... Massachusetts Institute Of Technology

01/29/15 / #20150030661

Multilayer films and uses thereof

The invention provides, inter alia, multilayer films of alternating layers of a glycosylated polymer (e.g. A mucin) and a lectin, as well as methods of making and using these films. ... Massachusetts Institute Of Technology

01/29/15 / #20150030659

Methods and compositions for the treatment of open and closed wound spinal cord injuries

Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. ... Massachusetts Institute Of Technology

01/29/15 / #20150030641

Glucose-responsive microgels for closed loop insulin delivery

Injectable insulin loaded microgels that are capable of modifying the amount of insulin released based on the patient's tissue glucose levels, methods for making and using these compositions have been developed. The microgels contain insulin, glucose oxidase entrapped in or bound to the microgels, and an agent that reduces hydrogen peroxide, entrapped in or bound to the microgels, wherein the polymeric microgel expands when ph decreases from physiological ph and shrinks when ph increases towards physiological ph, thereby releasing insulin at a rate corresponding to the glucose concentration. ... Massachusetts Institute Of Technology

01/29/15 / #20150029581

Thulium laser

Stimulating emission via thulium's lasing transition from the 3h4 manifold to the 3h6 manifold yields light at wavelength of about 820 nm. Unfortunately, excited thulium ions also transition from the 3h4 manifold to the long-lived 3f4 manifold, where they become trapped and can no longer participate in the lasing transition. ... Massachusetts Institute Of Technology

01/29/15 / #20150029505

Spark-induced breakdown spectroscopy electrode assembly

A spark-induced breakdown spectroscopy apparatus can have a housing with an inlet and an outlet that define an analyte flow path. A laser can define a laser pathway generally transverse to an intersecting the analyte flow path. ... Massachusetts Institute Of Technology

01/29/15 / #20150029058

Accurate timing distribution by high-frequency radio

A method of obtaining an absolute time reference for a high-frequency (hf) sounding signal includes transmitting a reference signal at a first location and transmitting a sounding signal in close proximity to the transmitting of the reference signal at the first location. The method additionally includes receiving the reference signal at a second location and receiving the sounding signal at the second location. ... Massachusetts Institute Of Technology

01/29/15 / #20150028346

Aluminum nitride based semiconductor devices

Semiconductor structures and techniques are described which enable forming aluminum nitride (ain) based devices by confining carriers in a region of ain by exploiting the polar nature of ain materials. Embodiments of ain transistors utilizing polarization-based carrier confinement are described.. ... Massachusetts Institute Of Technology

01/29/15 / #20150027529

Electrodes formed by oxidative chemical vapor deposition and related methods and devices

The present invention generally relates to electrodes formed by oxidative chemical vapor deposition and related methods and devices.. . ... Massachusetts Institute Of Technology

01/22/15 / #20150025505

Bi-directional motion of a lorentz-force actuated needle-free injector (nfi)

The present invention relate to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber of a plurality of chambers. ... Massachusetts Institute Of Technology

01/22/15 / #20150025005

Self-regulated peptide hydrogel for insulin delivery

A glucose binding amphiphilic peptide hydrogel insulin delivery system that is responsive to glucose concentrations under physiological conditions is provided. Insulin is encapsulated in a glucose binding hydrogel, made from self-assembling amphiphilic peptides including a hydrophobic domain including a beta sheet forming region coupled to a charged hydrophilic domain modified to contain a glucose binding segment. ... Massachusetts Institute Of Technology

01/22/15 / #20150023789

Wind turbine power augmentation

Wind power generator. The generator includes a wind turbine rotating in an aerodynamically contoured duct and capable of generating increased power by increasing the wind flow at the turbine. ... Massachusetts Institute Of Technology

01/22/15 / #20150023063

Resonant power converters using impedance control networks and related techniques

An impedance control resonant power converter (converter) operated at a fixed switching frequency includes an impedance control network (icn) coupled between two or more inverters operated at a fixed duty ratio with a phase shift between them and one or more rectifiers. The phase shift is used to control output power or compensate for variations in input or output voltage. ... Massachusetts Institute Of Technology

01/22/15 / #20150021480

Visible-infrared plane grating imaging spectrometer

An imaging spectrometer, covering the visible through infrared wavelengths, which disperses the light by a plane diffraction grating behind a wedged optical element. This design uses an achromatic doublet lens with a reflective coating on its convex back surface to produce the spectra on a flat detector. ... Massachusetts Institute Of Technology

01/15/15 / #20150020223

Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications

The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. ... Massachusetts Institute Of Technology

01/15/15 / #20150018665

Molecular and cellular imaging using engineered hemodynamic responses

According to some aspects, the invention relates to methods and compositions for evaluation of hemodynamic responses (e.g., using molecular imaging) with high sensitivity.. . ... Massachusetts Institute Of Technology

01/15/15 / #20150018220

Persistent-mode mri magnet fabricated from reacted, monofilamentary mgb2 wires and joints

A superconducting magnet and method for making a superconducting magnet, are presented. The superconducting magnet is made by forming a coil from windings of a first wire comprising a reacted mgb2 monofilament, filling a cavity of a stainless steel billet with a mg+b powder. ... Massachusetts Institute Of Technology

01/15/15 / #20150017120

Synergistic tumor treatment with extended-pk il-2 and adoptive cell therapy

The present invention provides a method of enhancing adoptive cell therapy (act) by administering an extended-pharmacokinetic (pk) interleukin (il)-2 to a cancer subject receiving act, optionally in combination with a therapeutic antibody. Methods of treating cancer and promoting tumor regression are also provided.. ... Massachusetts Institute Of Technology

01/15/15 / #20150016690

Methods and apparatus for refractive flow measurement

An imaging method and corresponding apparatus according to an embodiment of the present invention enables measurement and visualization of fluid flow. An embodiment method includes obtaining video captured by a video camera with an imaging plane. ... Massachusetts Institute Of Technology

01/15/15 / #20150014045

Sleeved coaxial printed circuit board vias

A printed circuit board, and a method of fabricating the printed circuit board is disclosed. The printed circuit board includes at least one coaxial via. ... Massachusetts Institute Of Technology

01/08/15 / #20150011830

Tip actuated disposable endoscope

The present invention relates to an endoscope having a motorized assembly to control the distal end of an endoscope. Preferred embodiments can include disposable and reusable components. ... Massachusetts Institute Of Technology

01/08/15 / #20150011404

Microfluidic bubble logic devices

Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices, and micro- and nanofluidic droplet/bubble memory elements for storage and retrieval of biological or chemical elements. The input sequence of bubbles/droplets encodes information, with the output being another sequence of bubbles/droplets or on-chip chemical synthesis. ... Massachusetts Institute Of Technology

01/08/15 / #20150009706

Optical structures including nanocrystals

An optical structure can include a nanocrystal on a surface of an optical waveguide in a manner to couple the nanocrystal to the optical field of light propagating through the optical waveguide to generate an emission from the nanocrystal. The structure can be configured to restrict propagation of the emission from the nanocrystal along the waveguide.. ... Massachusetts Institute Of Technology

01/08/15 / #20150007560

Turbocharged single cylinder internal combustion engine using an air capacitor

Internal combustion engine system. The system includes a single cylinder engine having an engine volume, the single cylinder engine having an intake manifold for introducing air into the engine and an exhaust manifold for discharge of exhaust gases. ... Massachusetts Institute Of Technology

01/01/15 / #20150007357

Use of humanized mice to determine toxicity

The invention is directed to a method of determining whether an agent causes immune toxicity in a human comprising administering the agent to a non-human mammal that has been engrafted with human hematopoietic stem cells (hscs) and administered one or more human cytokines; and determining whether the agent causes immune toxicity in the non-human mammal. If the agent causes immune toxicity in the non-human mammal then the agent causes toxicity in a human. ... Massachusetts Institute Of Technology

01/01/15 / #20150005701

Controlled needle-free transport

A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. ... Massachusetts Institute Of Technology

01/01/15 / #20150005646

Pulse detection from head motions in video

Heart rates and beat lengths can be extracted from videos by measuring subtle head motion caused by the newtonian reaction to the influx of blood at each beat. In an embodiment of the present invention, a method tracks features on the head and performs principal component analysis (pca) to decompose their trajectories into a set of component motions. ... Massachusetts Institute Of Technology

01/01/15 / #20150004710

Reagents for oxidizer-based chemical detection

Reagents and methods are disclosed for detection of oxidizers and inorganic salts and other analytes of interest. The reagents can interact with their target analytes, especially oxidizer compositions or oxidizer-based explosives, to selectively enhance their ionization yield, interacting by chemical reaction or by forming an associative adduct which facilitates their detection. ... Massachusetts Institute Of Technology

01/01/15 / #20150003557

Permute codes, iterative ensembles, graphical hash codes, and puncturing optimization

Described herein are new error-correction (channel) codes: permute codes, iterative ensembles of permute and spinal codes, and graphical hash codes. In one aspect, a wireless system includes an encoder configured to encode data using one of the aforementioned channel codes. ... Massachusetts Institute Of Technology

01/01/15 / #20150001539

Flexible high-voltage thin film transistors

A flexible high-voltage thin-film transistor includes a gate electrode, a source electrode, a drain electrode, a dielectric layer, and a flexible semiconductor layer. The flexible semiconductor layer serves as a channel for the transistor and is in electrical communication with the source electrode and the drain electrode. ... Massachusetts Institute Of Technology

01/01/15 / #20150001422

Wide-field imaging using nitrogen vacancies

Nitrogen vacancies in bulk diamonds and nanodiamonds can be used to sense temperature, pressure, electromagnetic fields, and ph. Unfortunately, conventional sensing techniques use gated detection and confocal imaging, limiting the measurement sensitivity and precluding wide-field imaging. ... Massachusetts Institute Of Technology

01/01/15 / #20150001153

Polymer particles and methods of using these for oil recovery

The invention provides methods that use particles comprising a polymer to absorb and recover oil. The methods can be used for oil spill cleanup, oil recovery, extraction of oil from an oil-water emulsion, etc. ... Massachusetts Institute Of Technology








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