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Massachusetts Institute Of Technology patents (2016 archive)


Recent patent applications related to Massachusetts Institute Of Technology. Massachusetts Institute Of Technology is listed as an Agent/Assignee. Note: Massachusetts Institute Of Technology may have other listings under different names/spellings. We're not affiliated with Massachusetts Institute Of Technology, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "M" | Massachusetts Institute Of Technology-related inventors


Wireless non-radiative energy transfer

Described herein are embodiments of a source high-q resonator, optionally coupled to an energy source, a second high-q resonator, optionally coupled to an energy drain that may be located a distance from the source resonator. A third high-q resonator, optionally coupled to an energy drain that may be located a distance from the source resonator. ... Massachusetts Institute Of Technology

Method and applications of thin-film membrane transfer

The disclosure relates to method and apparatus for micro-contact printing of micro-electromechanical systems (“mems”) in a solvent-free environment. The disclosed embodiments enable forming a composite membrane over a parylene layer and transferring the composite structure to a receiving structure to form one or more microcavities covered by the composite membrane. ... Massachusetts Institute Of Technology

T cell balance gene expression, compositions of matters and methods of use thereof

This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences t cell balance, for example, th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences t cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence t cell balance in a variety of therapeutic and/or diagnostic indications.. ... Massachusetts Institute Of Technology

Nickel pre-catalysts and related compositions and methods

Described herein are nickel pre-catalysts and related compositions and methods. The nickel pre-catalysts may be activated to form catalysts which may be utilized in organic reactions.. ... Massachusetts Institute Of Technology

Conductive aerogel

Electrically conductive aerogel and methods of making the same are disclosed. A solution is provided. ... Massachusetts Institute Of Technology

In vivo targeting of cells with ligand-conjugated particles

The invention provides compositions and methods for, inter alia, augmenting cell-based therapies in vivo by repeatedly stimulating target cells of interest over a period of time.. . ... Massachusetts Institute Of Technology

Uses of paralog-selective inhibitors of gsk3 kinases

The present disclosure provides methods of using gsk3α-selective inhibitors for treating fragile x syndrome, attention deficit hyperactivity disorder (adhd), childhood seizure, intellectual disability, diabetes, acute myeloid leukemia (aml), autism, and psychiatric disorder. The gsk3α-selective inhibitors include compounds of formula i-a. ... Massachusetts Institute Of Technology

System and method to improve image quality of emission tomography when using advanced radionuclides

A method and system for acquiring a series of medical images includes a plurality of detectors configured to be arranged to acquire gamma rays emitted from a subject as a result of an advanced radionuclide administered to the subject and communicate signals corresponding to acquired gamma rays. A data processing system is configured to receive the signals from the plurality of detectors, determine double coincidence event dataset and a multiple coincidence event dataset, separate the multiple coincidence event dataset into at least one of a standard lines of response dataset and a nonstandard lines of response dataset, and apply a background correction to the double coincidence event dataset based on the non-standard lines of response dataset and/or the standard lines of response dataset to obtain a standard coincidence dataset.. ... Massachusetts Institute Of Technology

Glycomic patterns for the detection of disease

This invention relates, in part, to methods and products for the detection of cancer, such as prostate cancer or multiple myeloma. This invention also relates, in part, to methods and products for the detection of prostate disease, such as benign prostatic hyperplasia (bph). ... Massachusetts Institute Of Technology

Paper-based immunoassay with polymerization-based signal amplification

Disclosed herein are paper-based immunoassays useful for the detection of analytes, kits for the same and methods of using the same.. . ... Massachusetts Institute Of Technology

Dye sensitized photoactive surfaces

Upon light irradiation, a dye sensitized photoactive surfaces can undergo hydrophobic to hydrophilic conversion in both in air and oil environments.. . ... Massachusetts Institute Of Technology

System and method for neuroendocrine control

The present invention relates to systems and methods for detecting and regulating neuroendocrine control. The systems involve measurement of real time pulsatile endocrine hormone levels in a subject and calculation of an appropriate dose of an analyte for treating the subject based on several factors. ... Massachusetts Institute Of Technology

Selective arylation of dichalcogenides in biomolecules

Disclosed are chemical transformations for the conjugation of unprotected peptide biomolecules. The processes feature several significant advantages over existing methods of peptide modification, including specificity towards selenocysteine over other nucleophiles (e.g., amines, hydroxyls), excellent functional group tolerance, and mild reaction conditions.. ... Massachusetts Institute Of Technology

Alkenyl substituted 2,5-piperazinediones, compositions, and uses thereof

Provided herein are compounds of formula (i), and salts thereof, wherein each instance of rl is independently optionally substituted c6-c40 alkenyl. Further provided are compositions comprising a compound of formula (i) and an agent. ... Massachusetts Institute Of Technology

12/15/16 / #20160366724

Multifunctional cnt-engineered structures

Various applications for structured cnt-engineered materials are disclosed herein. In one application, systems are disclosed, wherein a structured cnt-engineered material forms at least part of an object capable of providing its own structural feedback. ... Massachusetts Institute Of Technology

12/15/16 / #20160365216

Pyrolyzed porous carbon materials and ion emitters

Embodiments related to the use and production of porous carbon materials in ion emitters and other applications are described. . ... Massachusetts Institute Of Technology

12/15/16 / #20160364521

Methods to identify macromolecule binding and aggregation prone regions in proteins and uses therefor

The present invention provides methods and computational tools based, at least in part, on computer simulations that identify macromolecule binding regions and aggregation prone regions of a protein. Substitutions may then be made in these aggregation prone regions to engineer proteins with enhanced stability and/or a reduced propensity for aggregation. ... Massachusetts Institute Of Technology

12/08/16 / #20160359118

[2.2]paracyclophane-derived donor/acceptor-type molecules for oled applications

Disclosed are [2.2]paracyclophane-derivative compounds and related polymers that are useful as stable, efficient, blue-light emitting compounds for oled applications.. . ... Massachusetts Institute Of Technology

12/08/16 / #20160358077

System and method for quantifying and presenting information representative of technological improvements in a target technological domain based on patent metrics

Embodiments are disclosed herein for quantifying and presenting information representative of technological improvements in a technological domain based on patent metrics that may include receiving a request for a patent-based technological improvement rate in a target technological domain, selecting a set of patents representative of the technological domain from an online search of a patent database over a network, storing patent metadata in a memory for the set of patents received over the network from the online search of the patent database, calculating values for one or more patent metrics from the patent metadata for the technological domain, calculating the patent-based technological improvement rate for the technological domain by applying a predictive model to the one or more patent metric values for the technological domain, and communicating the patent-based technological improvement rate through an output communication interface for presentation through an output of an end user computing device.. . ... Massachusetts Institute Of Technology

12/08/16 / #20160355918

Activated aluminum fuel

Aluminum can be used as a fuel source when reacted with water if its native surrounding oxide coating is penetrated with a gallium-based eutectic. When discrete aluminum objects are treated in a heated bath of eutectic, the eutectic penetrates the oxide coating. ... Massachusetts Institute Of Technology

12/08/16 / #20160355849

Methods for conversion of food waste to chemical products

Aspects of the invention relate to methods for producing lactic acid from organic waste, comprising contacting organic waste with a microbial community to form a fermentation mixture, and fermenting the fermentation mixture under controlled ph and temperature conditions for a time sufficient to produce lactic acid.. . ... Massachusetts Institute Of Technology

12/08/16 / #20160355484

Articles and methods comprising persistent carbenes and related compositions

Articles and methods comprising persistent carbenes are provided, as well as related compositions. In some embodiments, a persistent carbene may be associated with a portion of a substrate (e.g., at least a portion of a surface on the substrate). ... Massachusetts Institute Of Technology

12/08/16 / #20160355233

Hybrid sensor-enabled electric wheel and associated systems, multi-hub wheel spoking systems, and methods of manufacturing and installing wheel spokes

Embodiments of hybrid sensor-enabled and autonomous electric wheels can include a plurality of systems and devices integrated into a single compact hub unit that can be retrofitted into numerous types of two-wheeled bicycles. In one embodiment, an electrically motorized bicycle wheel can include a wheel rim, a wheel hub having an electric motor, a battery pack and a control unit configured to control a drive torque of the electric motor, and a plurality of wheel spokes connecting the wheel rim to the wheel hub. ... Massachusetts Institute Of Technology

12/08/16 / #20160354332

Therapeutic strategies for treating mitochondrial disorders

Provided herein are methods, compositions, and systems for treating mitochondrial disorders (e.g., merrf, melas, kearns-sayre syndrome, chronic progressive external ophthalmoplegia, diabetes mellitus and deafness, lactic acidosis, leber's hereditary optic neuropathy, wolff-parkinson-white syndrome, leigh syndrome, narp, myoneurogenic gastrointestinal encephalopathy, mitochondrial dna depletion syndrome) or neurodegenerative diseases (e.g., alzheimer's disease, parkinson's disease) by administering aspartate, or an analog or prodrug thereof, or an agent that increases intracellular levels of aspartate. Pharmaceutical compositions and kits for use in treating mitochondrial disorders and neurodegenerative diseases are also described herein. ... Massachusetts Institute Of Technology

12/08/16 / #20160354034

Systems and methods for reducing scar formation about a neural implant

Systems, devices, and methods are provided for reducing scar formation about a neural implant due to brain tissue and neural implant movement. In an embodiment, a neural implant is provided which has a surface coating that matches one or more mechanical properties, such as elastic modulus, of the brain tissue, thereby reduce scar formation about the neural implant due to normal brain micromotion.. ... Massachusetts Institute Of Technology

12/01/16 / #20160350472

System for introspection and annotation of electronic circuit design data

. . A system for introspection and annotation of electronic design data includes a tracked probe that interacts with an electronic circuit, a tracking system, schematics, design files, or models for the circuit, electronic design system software, and a user interface. The probe has a sensor that tracks the position of the probe within the circuit. ... Massachusetts Institute Of Technology

12/01/16 / #20160348498

Compositions of and methods for making stable carbonaceous nanomaterials

A composition for stabilizing dispersed particles in an ionically charged solution is disclosed. The composition includes a carbonaceous substrate, the carbonaceous substrate operable to undergo a grafting-to approach for functionalization. ... Massachusetts Institute Of Technology

12/01/16 / #20160346099

Peripheral neural interface via nerve regeneration to distal tissues

At least partial function of a human limb is restored by surgically removing at least a portion of an injured or diseased human limb from a surgical site of an individual and transplanting a selected muscle into the remaining biological body of the individual, followed by contacting the transplanted selected muscle, or an associated nerve, with an electrode, to thereby control a device, such as a prosthetic limb, linked to the electrode. Simulating proprioceptive sensory feedback from a device includes mechanically linking at least one pair of agonist and antagonist muscles, wherein a nerve innervates each muscle, and supporting each pair with a support, whereby contraction of the agonist muscle of each pair will cause extension of the paired antagonist muscle. ... Massachusetts Institute Of Technology

11/24/16 / #20160341637

Microfluidic bubble logic devices

Fluid-based no-moving part logic devices are constructed from complex sequences of micro- and nanofluidic channels, on-demand bubble/droplet modulators and generators for programming the devices, and micro- and nanofluidic droplet/bubble memory elements for storage and retrieval of biological or chemical elements. The input sequence of bubbles/droplets encodes information, with the output being another sequence of bubbles/droplets or on-chip chemical synthesis. ... Massachusetts Institute Of Technology

11/24/16 / #20160340661

Delivery, use and therapeutic applications of the crispr-cas systems and compositions for genome editing

The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. ... Massachusetts Institute Of Technology

11/24/16 / #20160340569

Multifunctional particles for enhanced oil recovery

To deliver surfactants or tracers to underground oil fields, inorganic encapsulated surfactant nanoparticles or microparticles that are stable for several weeks under high temperature and high salt conditions can be used.. . ... Massachusetts Institute Of Technology

11/24/16 / #20160339627

Pre-stressed and constrained transformable materials

A transformable material and comprising a base material having a natural shape, with a second material disposed on the base material in a particular pattern so as to impose a transformed shape on the base material, the transformed shape being different than the natural shape. More particularly, the base material is a stretchable 2-dimensional material, and is subjected to pre-stressing before and during disposition of the second material, whereupon after release of the stress, the stretchable base material with the disposed second material thereon automatically transform into a predetermined 3-dimensional manufactured shape.. ... Massachusetts Institute Of Technology

11/24/16 / #20160339510

Methods and apparatus for actuated fabricator

In exemplary implementations of this invention, an actuated fabricator deposits structural elements (e.g., tensile structural elements) in a 3d pattern over large displacements. The fabricator is supported by at least three elongated support members. ... Massachusetts Institute Of Technology

11/24/16 / #20160339434

Inertio-elastic focusing of particles in microchannels

One example of systems and methods for inertio-elastic focusing of particles in microchannels includes a substrate including a channel having an inlet and an outlet. A viscoelastic fluid, i.e., a fluid having a dynamic viscosity that varies with shear rate, and that carries suspended particles is driven through the channel. ... Massachusetts Institute Of Technology

11/24/16 / #20160339429

Methods and apparatus for microfluidic perfusion

In illustrative implementations of this invention, microfluidic perfusion tubing is easily and precisely inserted into a microfluidic device. The tubing is inserted in a manner that aligns one or more holes in the perfusion tubing with one or more channels in the microfluidic device. ... Massachusetts Institute Of Technology

11/24/16 / #20160339393

Maintenance of gas layers for fouling prevention on submerged surfaces

An apparatus for enhanced anti-fouling of a submerged surface includes a bath of a feed liquid that includes water; a fouling structure in contact with the feed liquid; and a gas feed configured to introduce a gas into contact with the fouling structure and the feed liquid to separate the fouling structure from the feed liquid with a gas layer.. . ... Massachusetts Institute Of Technology

11/24/16 / #20160339150

Methods and compositions for the treatment of open and closed wound spinal cord injuries

Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. ... Massachusetts Institute Of Technology

11/24/16 / #20160338857

Artificial ankle-foot system with spring, variable-damping, and series-elastic actuator components

An artificial foot and ankle joint consists of a curved leaf spring foot member having a heel extremity and a toe extremity, and a flexible elastic ankle member that connects the foot member for rotation at the ankle joint. An actuator motor applies torque to the ankle joint to orient the foot when it is not in contact with the support surface and to store energy in a catapult spring that is released along with the energy stored in the leaf spring to propel the wearer forward. ... Massachusetts Institute Of Technology

11/17/16 / #20160336878

Poly-actuator

Similar to combustion engines including multiple cylinders engaged with a crankshaft, multiple piezoelectric stack actuators (psa) engaged with a common output rod can produce smooth, long stroke motion with desired properties. In particular, when equally spaced multiple units are arranged to push sinusoidal gear teeth on the output rod, the system exhibits unique collective behaviors thanks to “harmonic” effects of the multiple units. ... Massachusetts Institute Of Technology

11/17/16 / #20160336477

Eliminating emissive sub-bandgap states in nanocrystals

The size-dependent band-gap tunability and solution processability of nanocrystals (ncs) make them attractive candidates for optoelectronic applications. One factor that presently limits the device performance of nc thin films is sub-bandgap states, also referred to as trap states. ... Massachusetts Institute Of Technology

11/17/16 / #20160331784

Compositions, methods, and devices for treating disease

Described are compositions and methods for treating liver disease, e.g., acute liver disease, using bone marrow-derived stem cells and bone marrow-derived stem cell conditioned media.. . ... Massachusetts Institute Of Technology

11/17/16 / #20160331297

Integrated electrical profiling system for measuring leukocytes activation from whole blood

A system includes a microfluidic device configured to isolate one or more particles from a mixture, a flow rate matching device configured to match flow rate of the microfluidic device with flow rate of an electrical measurement device configured to measure an electrical property of the isolated particles, and an electrical measurement device configured to measure an electrical property of the isolated particles.. . ... Massachusetts Institute Of Technology

11/10/16 / #20160328635

Substrate pre-scanning for high throughput microscopy

Non-uniformities in substrate thickness and surface topography contribute significantly to the need for auto-focusing on a sample deposited thereon. These auto-focusing needs can be reduced or eliminated by measuring and storing substrate surface topography for later retrieval by an imaging system that can use the topographic information to help set appropriate focal parameters. ... Massachusetts Institute Of Technology

11/10/16 / #20160327471

T-peel test fixture

T-peel test fixture for a vertical test machine. The test fixture includes an upper grip for holding an arm of a peel specimen that has a hangover tail and a lower grip for holding the other arm of the peel specimen. ... Massachusetts Institute Of Technology

11/10/16 / #20160326535

Metabolic flux biosensor

Metabolic flux biosensors are provided herein, as are related compositions and methods useful for, inter alia, identifying factors which increase the production of metabolites and/or end products of metabolic pathways, and for the production of inter alia, metabolites and/or end products of metabolic pathways.. . ... Massachusetts Institute Of Technology

11/10/16 / #20160326431

One-pot method for preparing core-shell nanocrystals

A method for preparing a core-shell nanocrystal can include mixing an m-containing precursor solution, an x-containing precursor solution, and an acid or alcohol in an inert atmosphere at a first temperature to form a reaction mixture; maintaining the reaction mixture at the first temperature to grow the mx core of the nanocrystal; raising the temperature of the reaction mixture to a second temperature; and maintaining the reaction mixture at the second temperature to grow a shell of the nanocrystal.. . ... Massachusetts Institute Of Technology

11/10/16 / #20160326295

Broad wavelength range chemically tunable photonic materials

The present invention provides polymeric materials arranged as photonic crystals, or portions of photonic crystals, having properties which can be easily tuned over a large range of wavelengths upon exposure to an external stimulus. In some embodiments, the photonic crystals comprise at least one portion which can undergo a change in a physical, chemical, dielectric, or other property upon exposure to an altering stimulus, resulting in a change in a diffracted wavelength of electromagnetic radiation (e.g, light) by the photonic crystal. ... Massachusetts Institute Of Technology

11/10/16 / #20160325505

Micro-pillar methods and apparatus

A computer produces a digital model that efficiently describes a dense array of many micro-pillars. The digital model achieves this efficiency by describing an entire micro-pillar with only a few parameters. ... Massachusetts Institute Of Technology

11/10/16 / #20160325429

Modular angular-momentum driven magnetically connected robots

A modular robotic system that includes a plurality of self-configuring robots. Each self-configuring robot includes a frame structure having a plurality of cylindrical bonding magnets positioned along the edges of the frame structure. ... Massachusetts Institute Of Technology

11/10/16 / #20160324793

Modified alginates for cell encapsulation and cell therapy

Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for the encapsulation and transplantation of cells. ... Massachusetts Institute Of Technology

11/10/16 / #20160324206

Fused deposition model cold slurry printer

Fused deposition model printer system. The system prints cold slurry substances and includes a source of a cold slurry substance with a print platform supported for at least three axes of motion under computer control. ... Massachusetts Institute Of Technology

11/03/16 / #20160321519

Assisted surveillance of vehicles-of-interest

A computer-implemented image processing method includes accessing image data representing a plurality of images of a plurality of vehicles and reading a data model representing a predefined vehicle attribute. The method further includes processing a portion of the image data to detect a vehicle feature of at least one of the vehicles represented in at least one of the images based on the predefined vehicle attribute, and processing the portion of the image data to generate vehicle data representing the detected vehicle feature.. ... Massachusetts Institute Of Technology

11/03/16 / #20160320837

Methods and apparatus for retinal retroreflection imaging

A video camera captures images of retroreflection from the retina of an eye. These images are captured while the eye rotates. ... Massachusetts Institute Of Technology

11/03/16 / #20160319464

Methods and systems for manufacturing a tablet

Methods and systems for manufacturing a tablet are generally provided. Certain embodiments comprise electrodepositing (e.g., electrospinning) a material (e.g., the tablet material, for example, within a fluid) onto a substrate. ... Massachusetts Institute Of Technology

11/03/16 / #20160318048

Electrically-driven fluid flow and related systems and methods, including electrospinning and electrospraying systems and methods

Systems and methods in which the flow of fluid is electrically driven, including electrospinning and electrospraying systems and methods, are generally described.. . ... Massachusetts Institute Of Technology

11/03/16 / #20160317796

Triggerable shape memory induction devices

In accordance with the invention, compositions, devices, and related methods have been developed for medical-related and other applications. In some embodiments, the devices and compositions described herein comprise a triggerable shape memory polymer network. ... Massachusetts Institute Of Technology

11/03/16 / #20160317612

Engineered polypeptide agents for targeted broad spectrum influenza neutralization

The present invention provides novel agents for broad spectrum influenza neutralization. The present invention provides agents for inhibiting influenza infection by bind to the influenza virus and/or hemagglutinin (ha) polypeptides and/or ha receptors, and reagents and methods relating thereto. ... Massachusetts Institute Of Technology

11/03/16 / #20160317079

System and method for measuring skin movement and strain and related techniques

Described herein are systems and techniques for a motion capture system and a three-dimensional (3d) tracking system used to record body position and/or movements/motions and using the data to measure skin strain (a strain field) all along the body while a joint is in motion (dynamic) as well as in a fixed position (static). The data and technique can be used to quantify strains, calculate 3d contours, and derive patterns believed to reveal skin's properties during natural motions.. ... Massachusetts Institute Of Technology

10/27/16 / #20160313425

Micro magnetic resonance relaxometry

A low-cost and bench-top magnetic resonance relaxometer can be used for ex-vivo biochemical stress tests on plasma/erythrocytes, enabling deep-phenotyping of an individual's oxidative status, susceptibility and capacity.. . ... Massachusetts Institute Of Technology

10/27/16 / #20160311727

Alkali metal ion source with moderate rate of ion release and methods of forming

An alkali metal ion source with a moderate rate of release of the ion (e.g. Potassium) is formed by a method that includes: 1) combining an particulate ore that contains at least one of an alkali metal ion-bearing framework silicate (e.g. ... Massachusetts Institute Of Technology

10/20/16 / #20160307659

Coherent electron and radiation production using transverse spatial modulation and axial transfer

Coherent electronic current is generated by generating and transmitting an electron bunch along a longitudinal axis. The electron bunch is then directed onto a target, wherein the target imparts a transverse spatial modulation to the electron bunch via diffraction contrast or phase contrast. ... Massachusetts Institute Of Technology

10/20/16 / #20160307376

Hybrid sensor-enabled electric wheel and associated systems, multi-hub wheel spoking systems, and methods of manufacturing and installing wheel spokes

Embodiments of hybrid sensor-enabled and autonomous electric wheels can include a plurality of systems and devices integrated into a single compact hub unit that can be retrofitted into numerous types of two-wheeled bicycles. In one embodiment, an electrically motorized bicycle wheel can include a wheel rim, a wheel hub having an electric motor, a battery pack and a control unit configured to control a drive torque of the electric motor, and a plurality of wheel spokes connecting the wheel rim to the wheel hub. ... Massachusetts Institute Of Technology

10/20/16 / #20160305939

Stochastic arrangement of reagents in clusters - starc

The invention, in some aspects relates to compositions and methods for imaging biological systems and physiological activity and conditions in cells.. . ... Massachusetts Institute Of Technology

10/20/16 / #20160305856

Iterative expansion microscopy

The present invention leverages the techniques for expansion microscopy (exm) to provide improved high-throughput super-resolution whole-organ imaging methodology to image protein architectures over whole organs with nanoscale resolution by using high-throughput microscopes in combination with samples that have been iteratively expanded more than once, in a method referred to herein as “iterative expansion microscopy” (iexm). In the exm method, biological samples of interest are permeated with a swellable material that results in the sample becoming embedded in the swellable material, and then the sample can be expanded isotropically in three dimensions the process of iteratively expanding the samples can be applied to samples that have been already expanded using exm techniques one or more additional times to iteratively expand them such that, for example, a 5-fold expanded specimen can be expanded again 3- to 4-fold, resulting in as much as a 17- to 19-fold or more linear expansion.. ... Massachusetts Institute Of Technology

10/20/16 / #20160304861

Spatial multiplexing for multisignal cellular imaging

The invention, in some aspects, relates to methods, systems, and components of a high-content, single-cell resolution, spatial multiplex cell imaging system.. . ... Massachusetts Institute Of Technology

10/20/16 / #20160304158

Hybrid sensor-enabled electric wheel and associated systems, multi-hub wheel spoking systems, and methods of manufacturing and installing wheel spokes

Embodiments of hybrid sensor-enabled and autonomous electric wheels can include a plurality of systems and devices integrated into a single compact hub unit that can be retrofitted into numerous types of two-wheeled bicycles. In one embodiment, an electrically motorized bicycle wheel can include a wheel rim, a wheel hub having an electric motor, a battery pack and a control unit configured to control a drive torque of the electric motor, and a plurality of wheel spokes connecting the wheel rim to the wheel hub. ... Massachusetts Institute Of Technology

10/20/16 / #20160303046

Lipid vesicle compositions and methods of use

The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.. ... Massachusetts Institute Of Technology

10/20/16 / #20160302665

Methods and apparatus for visual cues for eye alignment

A retinal imaging device includes a camera, a light source, a projector, an i/o device and a computer. The projector emits two sets of light rays, such that one set of rays lies on an exterior surface of a first cone, and the other set of rays lie on an exterior surface of a second cone. ... Massachusetts Institute Of Technology

10/13/16 / #20160302134

Coding approach for a robust and flexible communication protocol

A coding approach for a robust and flexible network communication protocol is described. By using coding, it is possible to eliminate the need to track packet identities, and hence, it is possible to reduce coordination overhead associated with many conventional protocols. ... Massachusetts Institute Of Technology

10/13/16 / #20160301265

Wireless energy transfer

Disclosed is an apparatus for use in wireless energy transfer, which includes a first resonator structure configured to transfer energy non-radiatively with a second resonator structure over a distance greater than a characteristic size of the second resonator structure. The non-radiative energy transfer is mediated by a coupling of a resonant field evanescent tail of the first resonator structure and a resonant field evanescent tail of the second resonator structure.. ... Massachusetts Institute Of Technology

10/13/16 / #20160297549

Propellant tank and loading for electrospray thruster

Methods and apparatus of adding propellant to a thruster assembly are described. A first end of a beaker is disposed in an opening of the tank, where the beaker contains propellant and the first end of the beaker includes a breakaway bottom. ... Massachusetts Institute Of Technology

10/13/16 / #20160296985

Articles for manipulating impinging liquids and associated methods

Presented herein are articles and methods relating to manufactured superhydrophobic, superoleophobic, and/or supermetallophobic surfaces with macro-scale features (macro features) configured to induce controlled asymmetry in a liquid film produced by impinging phase (e.g., impinging droplet(s)) onto the surface, thereby further reducing the contact time between an impinging liquid and the surface.. . ... Massachusetts Institute Of Technology

10/13/16 / #20160296631

Drug delivery polymer and uses thereof

Described herein are platinum-based brush-arm star polymers (pt-basps), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as cisplatin. Also provided are methods and kits involving the pt-basps, or a pharmaceutical composition thereof, for treating proliferative diseases such as cancers (e.g., lung cancer, head-and-neck cancer, esophagus cancer, stomach cancer, breast cancer, pancreas cancer, liver cancer, kidney cancer, or prostate cancer) in a subject.. ... Massachusetts Institute Of Technology

10/13/16 / #20160296471

Surface binding of nanoparticle based drug delivery to tissue

Microparticles and nanoparticles and compositions thereof are provided. The microparticles and nanoparticles and compositions may be used for the treatment of musculoskeletal disease, such as osteoarthritis and injury such as trauma.. ... Massachusetts Institute Of Technology

10/13/16 / #20160296242

Method for automated opening of craniotomies for mammalian brain access

A method for automated opening of craniotomies includes, under the control of a computer processor, drilling into a skull for a predetermined distance and determining when there is a conductance drop near the drilling tip that indicates skull breakthrough. If the conductance is not below a predetermined threshold, drilling continues iteratively manner until conductance is below the threshold. ... Massachusetts Institute Of Technology

10/06/16 / #20160295151

Digital readout method and apparatus

Autonomously operating analog to digital converters are formed into a two dimensional array. The array may incorporate digital signal processing functionality. ... Massachusetts Institute Of Technology

10/06/16 / #20160290980

Detection of amines

A sensor can include a conductive region in electrical communication with at least two electrodes, the conductive region can include a complex, and the complex can include a carbon nanotube that is functionalized by a porphyrin.. . ... Massachusetts Institute Of Technology

10/06/16 / #20160289248

Articles and methods comprising persistent carbenes and related compositions

Articles and methods comprising persistent carbenes are provided, as well as related compositions. In some embodiments, a persistent carbene may be associated with a portion of a substrate (e.g., at least a portion of a surface on the substrate). ... Massachusetts Institute Of Technology

10/06/16 / #20160289173

Devices and methods for crystallizing a compound

The present invention generally relates to devices and methods for crystallizing a compound. In certain industries, crystallization techniques require additional filtration steps in order to obtain products of relatively high yield and/or high purity. ... Massachusetts Institute Of Technology

10/06/16 / #20160287870

Low power cochlear implants

In one aspect, the disclosure features systems for providing auditory signals to a subject. The systems include a sensor front-end circuit configured to be connected to an acoustic sensor and to convert analog signals received from the acoustic sensor to digital electric signals. ... Massachusetts Institute Of Technology

10/06/16 / #20160287622

Compositions and methods for treating immune and viral disorders and modulating protein-rna interaction

The present invention relates to methods of treating or decreasing the likelihood of developing a disorder associated with immune misregulation, such as, an autoimmune disorder, or viral or virus-associated disorder in a subject including administering to the subject a composition comprising an activator of a ccch zinc finger-containing parp, such as, parp13 or parp12. The present invention also relates to methods of treating a trail-resistant disorder, such as, trail-resistant cancer including administering to the subject a composition comprising an activator of a ccch zinc finger-containing parp, such as, parp13 or parp12. ... Massachusetts Institute Of Technology

09/29/16 / #20160285007

Organic conductive materials and devices

. . Embodiments described herein relate to compositions including bridged bicyclic compounds such as iptycene-based structures and extended iptycene structures. In some embodiments, the compositions may be useful in organic light-emitting diodes (oleds), organic photovoltaics, and other devices.. ... Massachusetts Institute Of Technology

09/29/16 / #20160284811

Electronics including graphene-based hybrid structures

Device are described that include a semiconductor material layer and at least one graphene-based electrode disposed over a portion of the semiconductor material layer, such that the at least one graphene-based electrode forms an overlap region with the semiconductor material layer. The device includes a means for providing charge carriers in the at least one graphene-based electrode proximate to the overlap region, to reduce a difference between a work function of the at least one graphene-based electrode and an electron affinity of the semiconductor material layer, to reduce a schottky barrier height between the semiconductor material layer and the at least one graphene-based electrode.. ... Massachusetts Institute Of Technology

09/29/16 / #20160281072

Crispr-cas systems and methods for altering expression of gene products

The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which encode one or more components of a crispr complex, as well as methods for the design and use of such vectors. ... Massachusetts Institute Of Technology

09/29/16 / #20160279630

Methods and apparatus for pipetting

A pipetting system identifies and records data regarding pipetting events, including the time and well into which a pipette dispenses liquid and the volume of liquid dispensed into the well. The pipetting system also measures and records other data regarding the context of pipetting events. ... Massachusetts Institute Of Technology

09/29/16 / #20160279246

Methods and systems for continuous heterogeneous crystallization

Methods of heterogeneous crystallization and related systems are provided. In some embodiments, a method comprises crystallizing an agent in a suspension comprising a heteronucleant and the dissolved agent. ... Massachusetts Institute Of Technology

09/22/16 / #20160277893

Sub-decimeter radio frequency ranging

A system enables a single wifi access point to localize clients to within tens of centimeters. Such a system can bring indoor positioning to homes and small businesses which typically have a single access point. ... Massachusetts Institute Of Technology

09/22/16 / #20160272623

Formation of macromolecules using iterative growth and related compounds

In some embodiments, macromolecules and related methods are provided. In some embodiments, an iterative growth process may be used to form a macromolecule comprising one or more repeat units comprising a functionalizable pendant group, with precise control over mass, length, backbone sequence, pendant group sequence, and/or stereochemistry, amongst other features. ... Massachusetts Institute Of Technology

09/15/16 / #20160270204

Phase-lock loop synchronization between beam orbit and rf drive in synchrocyclotrons

The invention specifies the use of feedback in the radio frequency (rf) drive for a synchrocyclotron, controlling the phase and/or amplitude of the accelerating field as a means to assure optimal acceleration of the beam, to increase the average beam current and to alter the beam orbit in order to allow appropriate extraction as the beam energy is varied. The effect of space charge is reduced by rapid acceleration and extraction of the beam, and the repetition rate of the pulses can be increased. ... Massachusetts Institute Of Technology

09/15/16 / #20160268832

Method and apparatus for wirelessly charging portable electronic devices

Wireless charging of portable electronic devices is carried out by detecting load variations caused by the device and dynamically compensating for these variations during charging to increase system efficiency and regulate delivered power. In some embodiments, load variations are tracked by comparing a feedback signal to a value range and determining whether the feedback value is higher than, lower than, or within the range of values. ... Massachusetts Institute Of Technology

09/15/16 / #20160268467

Metallic photovoltaics

According to some aspects, an apparatus for converting electromagnetic radiation into electric power is provided, comprising a first layer comprising a first semiconductor material, an absorber in contact with the first layer, a second layer comprising a second semiconductor material, the second layer being in contact with the absorber, and a reflector to reflect at least a portion of electromagnetic radiation passing through the second layer. According to some aspects, a method of forming an apparatus for converting electromagnetic radiation into electric power is provided, comprising forming a reflector on a substrate, forming a first layer in contact with the reflector, the first layer comprising a first semiconductor material, forming an absorber in contact with the first layer, and forming a second layer in contact with the absorber, the second layer comprising a second semiconductor material.. ... Massachusetts Institute Of Technology

09/15/16 / #20160267664

Methods and apparatus for modeling deformations of an object

Embodiments can be used to synthesize physically plausible animations of target objects responding to new, previously unseen forces. Knowledge of scene geometry or target material properties is not required, and a basis set for creating realistic synthesized motions can be developed using only input video of the target object. ... Massachusetts Institute Of Technology

09/15/16 / #20160266117

Compositions and methods for diagnosing and/or treating influenza infections

The present invention provides ha polypeptides (e.g., h1 ha polypeptides) that bind to umbrella-topology glycans, and reagents and methods relating thereto. The present invention provides binding agents that bind to ha polypeptides (e.g., h1 ha polypeptides), and reagents and methods relating thereto. ... Massachusetts Institute Of Technology

09/15/16 / #20160265089

Method for controlling the energy damping of a shape memory alloy with surface roughness

In a method for controlling energy damping in a shape memory alloy, provided is a shape memory alloy having a composition including at least one of: cu in at least about 10 wt. %, fe in at least about 5 wt. ... Massachusetts Institute Of Technology

09/15/16 / #20160265046

Spatial and cellular mapping of biomolecules in situ by high-throughput sequencing

The present invention relates to molecular microscopy or volumetric imaging by proximal unique molecular identifiers (“uid”) reaction (“vipur”) microscopy methods to record the cellular co-localization and/or spatial distributions of arbitrary nucleic acid sequences, or other biomolecules tagged with nucleic sequences. The method involves one or both of two dna sequence-components such as an α-uid, which may identify the targeted sequences-of-interest themselves and/or spatial beacons relative to which their distances are measured, and a −β-uid, which labels α-uid association events.. ... Massachusetts Institute Of Technology

09/15/16 / #20160264640

Water soluble membrane proteins and methods for the preparation and use thereof

The present invention is directed to water-soluble membrane proteins, methods for the preparation thereof and methods of use thereof.. . ... Massachusetts Institute Of Technology

09/15/16 / #20160263882

Carrier-substrate adhesive system

A system and method for creating three-dimensional nanostructures is disclosed. The system includes a substrate bonded to a carrier using a bonding agent. ... Massachusetts Institute Of Technology

09/15/16 / #20160263034

Manufacture of a pharmaceutical product

The invention concerns an emulsion-based method for the manufacture of a crystalized spherical agglomerate and/or a pharmaceutical product; and crystalized spherical agglomerate and/or a pharmaceutical product manufactured thereby.. . ... Massachusetts Institute Of Technology

09/08/16 / #20160261844

Methods and apparatus for enhancing depth maps with polarization cues

A 3d imaging system uses a depth sensor to produce a coarse depth map, and then uses the coarse depth map as a constraint in order to correct ambiguous surface normals computed from polarization cues. The imaging system outputs an enhanced depth map that has a greater depth resolution than the coarse depth map. ... Massachusetts Institute Of Technology

09/08/16 / #20160257386

Underwater vehicle design and control methods

Vehicles designed to use ground effect forces to control a positioning of the vehicle relative to a surface as well as their methods of use are described.. . ... Massachusetts Institute Of Technology

09/08/16 / #20160257385

Underwater vehicle design and control methods

Vehicles designed to use ground effect forces to control a positioning of the vehicle relative to a surface as well as their methods of use are described.. . ... Massachusetts Institute Of Technology

09/08/16 / #20160256670

Implantable devices and methods for evaluation of active agents

Devices for the local delivery of microdose amounts of one or more active agents, alone or in combination, in one or more dosages, to selected tissue of a patient are described. The devices generally include multiple microwells arranged on or within a support structure and contain one or more active agents, alone or in combination, in one or more dosages and/or release pharmacokinetics. ... Massachusetts Institute Of Technology

09/08/16 / #20160256386

Methods and compositions for localized agent delivery

The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.. ... Massachusetts Institute Of Technology

09/01/16 / #20160254754

Systems and methods for a variable frequency multiplier power converter

. . A power converter for converting dc power to dc power includes an inverter stage having two or more switched inverters configured to receive dc power from a source and produce a switched ac output power signal. A transformation stage is coupled to receive the switched output power signal from the inverter stage, shape the output power signal, and produce a shaped power signal. ... Massachusetts Institute Of Technology

09/01/16 / #20160254114

Self-aligned gated emitter tip arrays

Methods for fabrication of self-aligned gated tip arrays are described. The methods are performed on a multilayer structure that includes a substrate, an intermediate layer that includes a dielectric material disposed over at least a portion of the substrate, and at least one gate electrode layer disposed over at least a portion of the intermediate layer. ... Massachusetts Institute Of Technology

09/01/16 / #20160252652

Methods and apparatus for broadband angular selectivity of electromagnetic waves

A filter to transmit incident radiation at a predetermined incidence angle includes a plurality of photonic crystal structures disposed substantially along a surface normal direction of the filter. The photonic crystal structure includes a multilayer cell that comprises a first layer having a first dielectric permittivity, and a second layer having a second dielectric permittivity different from the first dielectric permittivity. ... Massachusetts Institute Of Technology

09/01/16 / #20160251662

Compositions and methods for treating cancer and modulating stress granule formation

The invention provides methods for treating or decreasing the likelihood of developing a stress-granule related disorder and/or cancer by administering one or more poly-adp-ribose polymerase (parp) inhibitors, one or more parp activators, one or more poly-adp-ribose glycosylase (parg) activators, and/or one or more poly-adp-ribose glycohydrolase arh3 activators. The invention also provides corresponding methods of decreasing stress granule formation and/or proliferation in a cell or a population of cells. ... Massachusetts Institute Of Technology

08/25/16 / #20160247591

Toroidal bending magnets for hadron therapy gantries

Toroidal superconducting magnets can be used as lightweight rotating bending magnets in hadron therapy gantries. The toroidal bending magnets are self-shielded and do not require ferromagnetic material for field modification or shielding, decreasing both the magnet system weight, as well as overall gantry weight. ... Massachusetts Institute Of Technology

08/25/16 / #20160245354

Beam-based nonlinear spring

Nonlinear spring. In one embodiment, the spring includes two opposed curved surfaces curving away from one another. ... Massachusetts Institute Of Technology

08/25/16 / #20160244784

Population-hastened assembly genetic engineering

Population-hastened assembly genetic engineering is a method for continuous genome recoding using a mixed population of cells. Nucleic acid donors are distributed amongst a population of cells that continuously transfer nucleic acids to achieve asynchronous recoding of genetic information within a subpopulation of the cells. ... Massachusetts Institute Of Technology

08/25/16 / #20160243254

Theranostic nanoprobes for overcoming cancer multidrug resistance and methods

Theranostic nanoprobes are provided for overcoming cancer multidrug resistance, and methods for treating biological tissue, including cancerous tissue. The theranostic nanoprobes may include gold nanoparticles functionalized with dna-hairpin. ... Massachusetts Institute Of Technology

08/25/16 / #20160243251

Artificial transcription factors comprising a sliding domain and uses thereof

The present invention relates to compositions which may comprise a non-naturally occurring or engineered artificial transcription factor, wherein the transcription factor may comprise a sequence specific dna binding domain, a sliding domain, and one or more linkers, wherein the dna binding domain and the sliding domain are operably connected by the one or more linkers, and uses thereof. Methods involving the use of a non-naturally occurring or engineered artificial transcription factors and pharmaceutical compositions, methods for treating cancer, a degenerative disease, a genetic disease or an infectious disease as well as diagnostic methods are also contemplated by the present invention.. ... Massachusetts Institute Of Technology

08/25/16 / #20160243197

Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness

The invention relates to methods of treating stress-sensitive psychiatric diseases arising from trauma in a subject by enhancing ghrelin signaling in the bla of the subject. The invention also relates to methods of reversing ghrelin resistance.. ... Massachusetts Institute Of Technology

08/25/16 / #20160243048

Cationic nanoparticles for co-delivery of nucleic acids and therapeutic agents

Nanoparticles containing an aqueous core containing one or more nucleic acids, such as sirna, and a shell containing one or more hydrophobic cationic materials, one or more amphiphilic materials, and one or more therapeutic, diagnostic, and/or prophylactic agents are. The hydrophobic cationic material and the hydrophobic portion of the amphiphilic material provide a non-polar polymer matrix for loading non-polar drugs, protect and promoting sirna molecule retention inside the np core, and control drug release. ... Massachusetts Institute Of Technology

08/18/16 / #20160240297

High-temperature superconducting high-current cables

High-temperature superconducting (hts) devices and methods are disclosed. An hts cable subassembly has a rectangular shaped cross section. ... Massachusetts Institute Of Technology

08/18/16 / #20160239606

Systems and methods for determining an unknown characteristic of a sample

Computerized analysis methods and systems to implement the computerized analysis methods are disclosed herein. Specifically, the present disclosure relates to systems and methods for determining an unknown characteristic of a sample.. ... Massachusetts Institute Of Technology

08/18/16 / #20160238593

Pumilio domain-based modular protein architecture for rna binding

A programmable modular protein architecture for rna binding comprises a set of modules, derived from rna-binding protein pumilio, that can be concatenated into chains of varying composition and length. When bound into a chain, each module has a preferred affinity for a specific rna base. ... Massachusetts Institute Of Technology

08/18/16 / #20160238591

Biopolymer-mediated assembly of nanoparticles using genetically encoded proteins

Various aspects and embodiments provided herein are directed to compositions that include at least one nanoparticle linked to a first polypeptide, and a biologically synthesizable polymer linked to at least one second polypeptide that binds covalently to the first polypeptide. Other aspects and embodiments provided herein are directed to methods of producing the foregoing compositions and components therein.. ... Massachusetts Institute Of Technology

08/18/16 / #20160238455

Compositions and methods for the downconversion of light

The present invention generally relates to composition and methods for downconverting light. In some embodiments, the composition and methods comprise an organic material, a nanocrystal, and a ligand capable of facilitating energy transfer between the organic material and the nanocrystal. ... Massachusetts Institute Of Technology

08/18/16 / #20160237343

Methods and compositions for the upconversion of light

The present invention generally relates to composition and methods for upconverting light. In some embodiments, the composition and methods comprise an organic material, a nanocrystal, and a ligand capable of facilitating energy transfer between the nanocrystal and the organic material. ... Massachusetts Institute Of Technology

08/18/16 / #20160235778

Compositions containing pufa, uridine and choline and methods of use thereof

The invention is directed to a method for increasing phosphatidylcholine in the blood of a subject comprising administering to the subject a composition having uridine or a metabolic precursor of uridine; choline or a metabolic precursor of choline; and at least one omega-3 fatty acid and/or omega-6 fatty acid, the phosphatidylcholine has a glycerol portion and the glycerol portion is bonded to two fatty acids and the total amount of carbons in the fatty acids is about 16 to 40 carbon atoms.. . ... Massachusetts Institute Of Technology

08/18/16 / #20160235324

Methods, systems, and apparatus for self-calibrating eeg neurofeedback

Methods, systems, and apparatus implementing a generalizable self-calibrating protocol coupled with machine learning algorithms in an exemplary setting of classifying perceptual states as corresponding to the experience of perceptually opposite mental states (including pain or no pain) are disclosed. An embodiment presented represents inexpensive, commercially available, wearable eeg sensors providing sufficient data fidelity to robustly differentiate the two perceptually opposite states. ... Massachusetts Institute Of Technology

08/11/16 / #20160231734

Methods and apparatus for handheld tool

In exemplary implementations of this invention, a computer-assisted, handheld machining tool allows even an inexperienced user to carve a complex 3d object, while maintaining artistic freedom to modify the sculpture from an initial cad design. The tool prevents the user from unintentionally removing material from a volume defined by the cad design. ... Massachusetts Institute Of Technology

08/11/16 / #20160231267

Devices and methods including a preconcentrator material for detection of analytes

Embodiments described herein provide devices and methods for the determination of analytes. The device typically includes an absorbent material that allows for an analyte sample to be concentrated and analyzed simultaneously and within a short period of time (e.g., less than 10 seconds). ... Massachusetts Institute Of Technology

08/11/16 / #20160229877

Metathesis catalysts and methods thereof

The present invention provides, among other things, novel compounds and methods for metathesis reactions. In some embodiments, a provided compound has the structure of formula i or ii. ... Massachusetts Institute Of Technology

08/11/16 / #20160229714

Hybridization of humidification-dehumidification and pressure-retarded osmosis

A carrier gas and a combined feed liquid are directed through a humidifier, where water vaporizes from the combined feed liquid into the carrier gas, and through a dehumidifier, where the combined feed liquid cools the carrier gas to condense water from the carrier gas. At least a portion of the concentrated brine stream from the humidifier is directed through a pressure-retarded osmosis unit, while an initial feed solution is directed, in counter-flow, through the osmosis unit. ... Massachusetts Institute Of Technology

08/11/16 / #20160228507

Isolated mucins and different microorganisms, and methods of use

A method of altering intercellular interactions between a combination of microorganisms includes contacting a combination of different species of microorganisms with at least one mucin. Isolated compositions include a combination of microorganisms and at least one mucin. ... Massachusetts Institute Of Technology

08/11/16 / #20160228465

Modified saponins for the treatment of fungal infections

Methods of treating a fungal infection in a subject, the method comprising administering to the subject a modified saponin.. . ... Massachusetts Institute Of Technology

08/11/16 / #20160228265

Artificial human limbs and joints employing actuators, springs and variable damper elements

It is to be understood that the methods and apparatus which have been described above are merely illustrative applications of the principles of the invention. Numerous modifications may be made by those skilled in the art without departing from the true spirit and scope of the invention.. ... Massachusetts Institute Of Technology

08/04/16 / #20160227508

Transponder localization

A method processes a concurrently triggered response signal at a number of transceivers configured to operate at a channel carrier frequency, where at least some of the transceivers have distinct transmit carrier frequencies offset from the channel carrier frequency. The method includes receiving, at a first receiver, a response signal in response to a trigger signal, the response signal including a combination of a number of transceiver response signals, each transceiver response signal of the number of transceiver response signals corresponding to a different transceiver of the number of transceivers and having a distinct transmit carrier frequency, wherein at least some of the transceiver response signals overlap in time, and determining characteristics of the number of transceivers based on the carrier frequencies of the transceiver response signals, including determining a number of transceivers in the number of transceivers.. ... Massachusetts Institute Of Technology

08/04/16 / #20160226095

Sodium-conducting solid electrolyte

A sodium-conductive solid-state electrolyte material includes a compound of the composition na10mp2s12, wherein m is selected from ge, si, and sn. The material may have a conductivity of at least 1.0×10−5 s/cm at a temperature of about 300k and may have a tetragonal microstructure, e.g., a skewed p1 crystallographic structure. ... Massachusetts Institute Of Technology

08/04/16 / #20160225887

Control of current collapse in thin patterned gan

A gan device is formed on a semiconductor substrate having a plurality of recessed regions formed in a surface thereof. A seed layer, optional buffer layer, and gallium nitride layer such as a carbon-doped gallium nitride layer are successively deposited within the recessed regions improved current collapse response of the gan device is attributed to maximum length and width dimensions of the multilayer stack.. ... Massachusetts Institute Of Technology

08/04/16 / #20160223988

Transparent flat-panel holographic display

A flat-panel holographic video display includes a control layer and waveguide elements. Each waveguide element has a light-guiding substrate and an array of transducers configured to produce a diffraction grating comprising surface acoustic waves. ... Massachusetts Institute Of Technology

08/04/16 / #20160222050

Mutagenic nucleoside analogs and uses thereof

The present disclosure provides nucleoside analogs of formula (i) or (ii). The nucleoside analogs are expected to show multiple tautomerism and may increase the mutation of an rna and/or dna (be mutagenic) of a virus or cancer cell. ... Massachusetts Institute Of Technology

08/04/16 / #20160220727

Self-assembling underwater adhesives

Compositions, methods, and kits are provided which involve novel fusion protein-based adhesives for use in medical and marine applications. In some aspects, the novel fusion proteins comprise an adhesive domain (e.g., derived from an adhesive protein of a marine organism) and an amyloid domain (e.g., derived from a bacterial amyloid protein). ... Massachusetts Institute Of Technology

07/28/16 / #20160218759

Digital matching of a radio frequency antenna

. . A matching technique that may be used with electrically small antennas uses one or more digital circuit blocks connected in a feedback arrangement configured to tune the transfer function response between the antenna and an output port of the system. Each circuit block may include an analog-to-digital converter (adc), a digital filter, and a digital-to-analog converter (dac). ... Massachusetts Institute Of Technology

07/28/16 / #20160217701

System and method for real-time analysis and guidance of learning

The present disclosure features systems and methods for analyzing student learning and calibrating the difficulty of questions on a test or examination. In one embodiment, a method for analyzing the learning of a student includes administering, by an assessment agent, a task to a student, the task comprising a question having an associated difficulty. ... Massachusetts Institute Of Technology

07/28/16 / #20160217315

Systems, methods, and apparatus for in vitro single-cell identification and recovery

Described herein are systems, methods, and apparatus for automatically identifying and recovering individual cells of interest from a sample of biological matter, e.g., a biological fluid. Also described are methods of enriching a cell type of interest. ... Massachusetts Institute Of Technology

07/28/16 / #20160213477

Orthopaedic joints providing enhanced lubricity

The present disclosure provides, among other things, prosthetic joint components having textured surface(s) for improving lubrication and increasing the useful life of the prosthetic joint components. The textured surface includes solid features configured to stably contain a biological fluid or a synthetic biological fluid therebetween or therewithin for a non-zero residence time.. ... Massachusetts Institute Of Technology

07/21/16 / #20160209319

Systems, methods, and apparatus for in vitro single-cell identification and recovery

. . Described herein are systems, methods, and apparatus for automatically identifying and recovering individual cells of interest from a sample of biological matter, e.g., a biological fluid. Also described are methods of enriching a cell type of interest. ... Massachusetts Institute Of Technology

07/21/16 / #20160208323

Methods for shearing and tagging dna for chromatin immunoprecipitation and sequencing

Disclosed are methods for shearing and tagging chromatin dna. The disclosed methods include contacting chromatin dna with at least one transposome, that includes a transposase enzyme. ... Massachusetts Institute Of Technology

07/21/16 / #20160207201

Neuromuscular model-based sensing and control paradigm for a robotic leg

A neuromuscular model-based controller for a robotic limb having at least one joint includes a neuromuscular model having a muscle model, muscle geometry and reflex feedback loop to determine at least one torque or impedance command to be sent to the robotic limb. One or more parameters that determine relation between feedback data and activation of the muscle model are adjusted consequent to sensory data from at least one of an intrinsic sensor and an extrinsic sensor. ... Massachusetts Institute Of Technology

07/21/16 / #20160206197

Methods and apparatus for anterior segment ocular imaging

A projector and one or more optical components project a light pattern that scans at least a portion of an anterior segment of an eye of a user, while one or more cameras capture images of the anterior segment. During each scan, different pixels in the projector emit light at different times, causing the light pattern to repeatedly change orientation relative to the eye and thus to illuminate multiple different cross-sections of the anterior segment. ... Massachusetts Institute Of Technology

07/14/16 / #20160204795

Systems and methods for model-free compression and model-based decompression

An encoder generates a compressed data sequence from an original data sequence using many-to-one mapping independently of a source model associated with the original data sequence and without extracting the source model. A decoder uses both the source model associated with the original data sequence and the mapping applied during compression that is devoid of, in substance, the source model, to regenerate, at least in part, the original uncompressed data sequence from the compressed data sequence that does not include a significant portion of the source model.. ... Massachusetts Institute Of Technology

07/14/16 / #20160204326

Fabrication of stable electrode/diffusion barrier layers for thermoelectric filled skutterudite devices

Disclosed are methods for the manufacture of n-type and p-type filled skutterudite thermoelectric legs of an electrical contact. A first material of cosi2 and a dopant are ball-milled to form a first powder which is thermo-mechanically processed with a second powder of n-type skutterudite to form a n-type skutterudite layer disposed between a first layer and a third layer of the doped-cosi2. ... Massachusetts Institute Of Technology

07/14/16 / #20160203382

Compressive sensing with local geometric features

Methods and apparatuses for compressive sensing that enable efficient recovery of features in an input signal based on acquiring a few measurements corresponding to the input signal. One method of compressive sensing includes folding an image to generate first and second folds, and recovering a feature of the image based on the first and second folds without reconstructing the image. ... Massachusetts Institute Of Technology

07/14/16 / #20160201881

Transparent luminescent displays enabled by electric-field-induced quenching of photoluminescent pixels

A light emitting device can include a light source, a first electrode, a second electrode, a first barrier layer, a second barrier layer, and an emitter layer between the first barrier layer and the second barrier layer. A method of controllably generating light can comprise two states: an on state, wherein an emitter layer of a device (which includes a photoluminescent pixel) is illuminated with a light source in the absence of an electric field, and the emitter layer generates light through photoluminescence; and an off state, wherein an emitter layer of a device (which includes a photoluminescent pixel) is illuminated with a light source in the presence of a static or time-varying electric field, and the electric field or induced current results in quenching of the emitter photoluminescence.. ... Massachusetts Institute Of Technology

07/14/16 / #20160200971

Highly luminescent semiconductor nanocrystals

A method of making a semiconductor nanocrystal can include contacting an m-containing compound with an x donor having the formula x(y(r)3)3, where x is a group v element and y is a group iv element.. . ... Massachusetts Institute Of Technology

07/07/16 / #20160197542

Controlled needle-free transport

A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. ... Massachusetts Institute Of Technology

07/07/16 / #20160195504

Methods and devices for deposition of materials on patterned substrates

Methods for depositing materials on patterned substrates, and related devices, are generally provided. In some embodiments, a material is deposited on a patterned substrate. ... Massachusetts Institute Of Technology

07/07/16 / #20160194604

Compositions and methods for epithelial stem cell expansion and culture

Described are cell culture solutions and systems for epithelial stem cell and organoid cultures, formation of epithelial constructs and uses of the same in transplantation. A single layer of epithelial cells that actively self-renews and is organized into crypts and villi clothes the intestine. ... Massachusetts Institute Of Technology

07/07/16 / #20160194415

Catechol-rich polymers from n-substituted maleimides

Disclosed are monomers, polymers and a method of making polymers that retain the ability of the polymer to from reversible and irreversible bonds. Gels comprising the polymers have the ability to coordinate metal ions and bind biopolymers.. ... Massachusetts Institute Of Technology

07/07/16 / #20160193792

Production of composite parts

A process for producing a composite part includes (a) applying a loose carbon filament to a receiving portion of a first mold piece; (b) reversibly coupling the first mold piece with at least a second mold piece to form a first mold layer, wherein an interior region of the first mold layer includes a pocket configured to receive a curable resin, the pocket having a shape of the composite part; (c) infusing the curable resin into the pocket; and (d) curing the resin to form the composite part.. . ... Massachusetts Institute Of Technology

07/07/16 / #20160193605

Selective delivery of material to cells

Isolating or identifying a cell based on a physical property of said cell can include providing a cell suspension; passing said suspension through a microfluidic channel that includes a constriction; passing the cell suspension through the constriction; and, contacting said cell suspension solution with a compound. The constriction can be sized to preferentially deform a relatively larger cell compared to a relatively smaller cell.. ... Massachusetts Institute Of Technology

07/07/16 / #20160192701

Filter materials including functionalized cellulose

Embodiments described herein provide materials and methods for the absorption or filtration of various species and analytes. In some cases, the materials may be used to remove or reduce the amount of a substance in vapor sample (e.g., cigarette smoke).. ... Massachusetts Institute Of Technology

06/16/16 / #20160172714

Multi-element liquid metal battery

An electrochemical cell includes a negative electrode having at least two active metals, a positive electrode having a metal or alloy, and an electrolyte having a cation of each of the active metals. The electrolyte defines first and second interfaces with the positive electrode being in contact with the first interface and the negative electrode being in contact with the second interface. ... Massachusetts Institute Of Technology

06/16/16 / #20160172180

Methods, apparatus, and system for mass spectrometry

A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 amu. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments. ... Massachusetts Institute Of Technology

06/16/16 / #20160170285

Optoelectronic filter

An optoelectronic filter having at least one input and an output includes a modulator circuit having at least first and second inputs with a first one of the modulator circuit inputs adapted to couple to a respective one of the at least one input of the optoelectronic filter. The modulator circuit receives at least a first radio frequency (rf) signal having a first power level and a second rf signal having a second, different power level at the first one of the modulator circuit inputs and in response thereto generates a modulated signal at an output thereof. ... Massachusetts Institute Of Technology

06/16/16 / #20160169810

Selective detection of alkenes or alkynes

A detector can detect an analyte including a carbon-carbon multiple bond moiety and capable of undergoing diels-alder reaction with a heteroaromatic compound having an extrudable group. The detector can detect, differentiate, and quantify ethylene.. ... Massachusetts Institute Of Technology

06/16/16 / #20160168594

Oncogenic models based on delivery and use of the crispr-cas systems, vectors and compositions

The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. ... Massachusetts Institute Of Technology

06/16/16 / #20160168165

Myc modulators and uses thereof

The present disclosure provides compounds of formula (i-a), formula (i), and formula (ii). The compounds described herein may be myc modulators (e.g., myc inhibitors) and may be useful in treating in a subject in need thereof diseases associated with myc and proliferative diseases (e.g., cancer). ... Massachusetts Institute Of Technology

06/16/16 / #20160168162

Luminescent compound and electroluminescent device exhibiting thermally activated delayed fluorescence

A chemical compound is provided having a structure that includes at least one donor moiety covalently bonded to at least one acceptor moiety. For example, the compound may include an indolocarbazole moiety covalently bonded to at least one furylpyridine moiety. ... Massachusetts Institute Of Technology

06/16/16 / #20160167306

Systems and methods of hierarchical material design for additive fabrication

According to some aspects, a method of designing a three-dimensional object based on a shape of the object, the object to be fabricated via additive fabrication from a plurality of materials, is provided. The method comprises selecting, for a first volume element of the object, one of the plurality of materials based at least in part on a position of the first volume element within the object, at least one spatial decomposition of the object, the at least one spatial decomposition identifying a plurality of volumetric subregions of the object, and a material composition of at least a first volumetric subregion of the plurality of volumetric subregions, wherein the first volumetric subregion comprises the position of the first volume element.. ... Massachusetts Institute Of Technology

06/16/16 / #20160166803

Systems and methods for delivering chemical and electrical stimulation across one or more neural circuits

Systems, devices, and methods are provided for delivering chemical and electrical stimulation across one or more neural circuits. The systems, devices, and methods can also be used for sensing and recording specific neural activity. ... Massachusetts Institute Of Technology

06/09/16 / #20160164451

Spectrally-engineered solar thermal photovoltaic devices

A solar thermal photovoltaic device, and method of forming same, includes a solar absorber and a spectrally selective emitter formed on either side of a thermally conductive substrate. The solar absorber is configured to absorb incident solar radiation. ... Massachusetts Institute Of Technology

06/09/16 / #20160164394

Electropermanent magnet-based motors

An electropermanent linear actuator has a stator, forcer, drive circuitry, and feedback control mechanism. The stator includes at least one electropermanent magnet with a coil that passes current pulses that change the magnetization of the magnet, which change persists after current is removed. ... Massachusetts Institute Of Technology

06/09/16 / #20160163904

2-terminal metal halide semiconductor/c-silicon multijunction solar cell with tunnel junction

A 2-terminal multi-junction solar cell having a thin film of metal halide semiconductor as the top solar-cell material and crystalline silicon as the bottom solar-cell material. In the illustrative embodiment, the top solar-cell material is a perovskite of the form am(ixh1-x)3, where a is a cation, preferably methylammonium (ch3nh3), formamidinium ([r2n—ch═nr2]+), or cesium; m is metal, preferably pb, sn, ge; h is a halide, preferably br or cl; and x=iodine fraction, in the range of 0 to 1, inclusive. ... Massachusetts Institute Of Technology

06/09/16 / #20160161479

Optoelectronic detection system

The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the target particle to be detected, where binding of the target particle to the receptors directly or indirectly activates a reporter molecule, thereby producing a measurable optical signal.. ... Massachusetts Institute Of Technology

06/09/16 / #20160161433

Electrospun polymer fibers for gas sensing

Disclosed herein are fibers made from intrinsically conductive polymers, such as polyaniline, that are useful as chemiresistive gas sensors. The experimental results, based on both sensitivity and response time, show that doped pani fibers are excellent ammonia sensors. ... Massachusetts Institute Of Technology

06/09/16 / #20160159038

Grafted polymer surfaces for dropwise condensation, and associated methods of use and manufacture

Presented herein are articles and methods featuring substrates with thin, uniform polymeric films grafted (e.g., covalently bonded) thereupon. The resulting coating provides significant reductions in thermal resistance, drop shedding size, and degradation rate during dropwise condensation of steam compared to existing coatings. ... Massachusetts Institute Of Technology

06/09/16 / #20160159010

Automated three-dimensional printer part removal

Three-dimensional printing system with automated part removal. In one embodiment, the system includes a printing surface on which a part is made and a printing device supported for controlled movement with respect to the printing surface to print the part on the printing surface. ... Massachusetts Institute Of Technology

06/09/16 / #20160158363

Multi-tailed lipids and uses thereof

The present invention provides multi-tailed lipid compounds, and salts and stereoisomers thereof, and methods of preparing the compounds. Also provided are compositions including a compound of the invention and an agent (e.g., an sirna, mrna, plasmid dna, small molecule, protein, peptide). ... Massachusetts Institute Of Technology

06/02/16 / #20160157127

Method and apparatus for packet capture using preambles and postambles

In a transmitting device, packets are generated that include both preambles and postambles under some network conditions and packets are generated that include only a preamble or a postamble under other network conditions. Both the preamble and the postamble of the packets may include information that can be used by a receiver device in receipt of a packet to determine that a packet has arrived. ... Massachusetts Institute Of Technology

06/02/16 / #20160155534

Thermally-drawn fiber including porosity

There is provided a fiber that includes a fiber material disposed along a longitudinal-axis fiber length. A porous domain has a porous domain length along at least a portion of the fiber length, within the fiber material. ... Massachusetts Institute Of Technology

06/02/16 / #20160155346

System and method for learning recommendation simulation

A method and system for learning recommendation simulations for an online learning environment includes a topic graph generator, a virtual learner generator, and a learning recommendation simulator, a virtual learner traverses topics on the topic graph and learns from learning nuggets included in each topic. The virtual learner's learning performance is assessed and used to modify learning nugget attributes for each of the learning nuggets.. ... Massachusetts Institute Of Technology

06/02/16 / #20160154960

Systems and methods for risk rating framework for mobile applications

Systems, methods and computer readable medium for training a risk rating system for assessing a risk of a mobile application are disclosed. One or more features representing operational characteristics of mobile applications and malware are extracted. ... Massachusetts Institute Of Technology

06/02/16 / #20160153006

Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation

The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a crispr complex, as well as methods for the design and use of such vectors. ... Massachusetts Institute Of Technology

06/02/16 / #20160153005

Delivery and use of the crispr-cas systems, vectors and compositions for hepatic targeting and therapy

The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. ... Massachusetts Institute Of Technology

06/02/16 / #20160152890

Compositions, articles, and methods for down-converting light and other applications

The present invention generally relates to compositions, articles, and methods for down-converting light and other applications. In some embodiments, the articles comprise a substrate and a composition comprising one or more types of polymers and one or more additives. ... Massachusetts Institute Of Technology

06/02/16 / #20160152638

Multistimuli-responsive white luminescent materials including metal elements

Combined lanthanide metal (ln(iii))-coordination complex fluorescence can provide a versatile molecular platform for design of white-light-emitting materials with advanced multistimuli-responsive properties. Red, green and blue light emitting ln(iii) complexes can be combined in solution or in a polymer complex to achieve white luminescent materials responsive to various external stimuli (e.g. ... Massachusetts Institute Of Technology

06/02/16 / #20160152059

Nanoporous stamp for flexographic printing

A nanoporous stamp for printing a variety of materials is disclosed. The nanoporous stamp may include a substrate and an array of carbon nanotubes disposed on and attached to the substrate. ... Massachusetts Institute Of Technology

06/02/16 / #20160151756

Compositions and methods for arranging colloid phases

The present invention generally relates to colloids and methods for changing the arrangement of droplet phases. In some embodiments, the colloids and methods comprise a plurality of droplets comprising two or more components, such that the two or more components can change arrangement of the components in the presence of an external stimulus. ... Massachusetts Institute Of Technology

06/02/16 / #20160151753

Compositions and methods for forming emulsions

The present invention generally relates to compositions and methods for forming droplets and/or emulsions. In some embodiments, the compositions and methods comprise two or more components miscible at a first temperature and immiscible at a second temperature, dispersed in an outer phase.. ... Massachusetts Institute Of Technology

06/02/16 / #20160151568

Systems and methods for delivering a therapeutic agent using mechanical advantage

Devices and methods for delivering a therapeutic agent to a patient are disclosed herein. In one embodiment, a delivery system includes a reservoir containing a fluid and a fluid communicator in fluid communication with the reservoir. ... Massachusetts Institute Of Technology

06/02/16 / #20160151404

Nucleic acid particles, methods and use thereof

The present invention provides, among other things, a particle which includes a core comprised of self-assembled one or more nucleic acid molecules, the core being characterized by an ability to adopt at least two configurations: a first configuration having a first greatest dimension greater than 2 μm and; a second configuration having a second greatest dimension less than 500 nm, wherein addition of a film coating converts the core from its first configuration to its second configuration. Methods of making and using of provided particles are also disclosed.. ... Massachusetts Institute Of Technology

05/26/16 / #20160148072

Assisted surveillance of vehicles-of-interest

A computer-implemented image processing method includes accessing image data representing a plurality of images of a plurality of vehicles and reading a data model representing a predefined vehicle attribute. The method further includes processing a portion of the image data to detect a vehicle feature of at least one of the vehicles represented in at least one of the images based on the predefined vehicle attribute, and processing the portion of the image data to generate vehicle data representing the detected vehicle feature.. ... Massachusetts Institute Of Technology

05/26/16 / #20160148038

Systems, apparatus, and methods for analyzing blood cell dynamics

Systems, apparatus, and methods for non-invasively detecting a white blood cell (wbc) event from in vivo capillary data may include obtaining a plurality of images, followed by specifying two-dimensional (2d) coordinates corresponding to internal contour and external contour of a capillary visible in the images. The two sets of 2d coordinates may be resampled to generate two sets of resampled coordinates, between which intermediate curves, including a middle curve, are generated. ... Massachusetts Institute Of Technology

05/26/16 / #20160147153

Systems, devices, and methods for printing on three-dimensional objects

Systems, devices, and methods for printing on surfaces of three-dimensional objects are provided. The systems, devices, and methods allow for images, and three-dimensional structures, to be printed onto a surface of a three-dimensional object. ... Massachusetts Institute Of Technology

05/26/16 / #20160145553

Modular platform for multi-tissue integrated cell culture

The systems and methods disclosed herein are generally related to a cell culture system. More particularly, the systems and methods enable the culturing and interconnecting of a plurality of tissue types in a biomimetic environment. ... Massachusetts Institute Of Technology

05/26/16 / #20160144068

Nanocomposite hydrogels

Provided herein are hemostatic compositions useful for treating wounds in a patient in need thereof. An exemplary hemostatic comprises gelatin or a derivative thereof and silicate nanoparticles. ... Massachusetts Institute Of Technology

05/26/16 / #20160143848

Neat liquid pharmaceutical formulations

Essentially non-aqueous liquid pharmaceutical formulations are formed by mixing at least one pharmaceutically active ingredient and at least one other compound capable of interacting with the active pharmaceutical ingredient through non-covalent interactions to form a low-temperature transition mixture. The stable liquid formulations are readily obtained, even with drugs that are poorly soluble and/or unstable in water.. ... Massachusetts Institute Of Technology

05/19/16 / #20160140448

Systems and methods for improving petroleum fuels production

A method for selecting one or more crude oils from a plurality of crude oils. In some embodiments, a plurality of scenarios may be generated, each scenario comprising a plurality of values corresponding, respectively, to a plurality of uncertain parameters, the plurality of uncertain parameters comprising at least one uncertain parameter relating to a quality of a crude oil of the plurality of crude oils. ... Massachusetts Institute Of Technology

05/19/16 / #20160138904

Methods and apparatus for imaging of occluded objects

An active imaging system, which includes a light source and light sensor, generates structured illumination. The light sensor captures transient light response data regarding reflections of light emitted by the light source. ... Massachusetts Institute Of Technology

05/19/16 / #20160138529

Fuel management system for variable ethanol octane enhancement of gasoline engines

Fuel management system for efficient operation of a spark ignition gasoline engine. Injectors inject an anti-knock agent such as ethanol directly into a cylinder of the engine. ... Massachusetts Institute Of Technology

05/19/16 / #20160138174

Electrochemically responsive composites of redox polymers and conducting fibers

Disclosed are composite compositions, comprising a conductive matrix and an electrochemically active polymer, which are useful as heterogeneous catalysts or charge-storage materials. Suitable electrochemically active polymers include redox polymers, such as polyvinylferrocene, and conducting polymers, such as polypyrrole, and interpenetrating networks containing both redox polymers and conducting polymers.. ... Massachusetts Institute Of Technology

05/19/16 / #20160137785

Poly(beta-amino alcohols), their preparation, and uses thereof

A new class of poly(beta-amino alcohols) (pbaas) has been prepared using combinatorial polymerization. The inventive pbaas may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. ... Massachusetts Institute Of Technology

05/19/16 / #20160136579

Minor component ratio balancing in filtration systems, and associated methods

Filtration systems in which the ratios of minor components in mixtures can be balanced, and associated methods, are generally described. Certain embodiments are related to methods in which a portion of a retentate stream produced by filtering an initial liquid feed during a first filtration step is mixed with the permeate produced by filtering the permeate from the first filtration step. ... Massachusetts Institute Of Technology

05/19/16 / #20160136578

Flow control in multi-step filtration, and associated systems

Flow control in multi-step filtration systems and associated methods are generally described. Certain embodiments are related to methods in which a single filter is used to perform multiple, separate filtration steps. ... Massachusetts Institute Of Technology

05/19/16 / #20160136577

Concentration control in filtration systems, and associated methods

Concentration control in filtration systems and associated methods are generally described. Streams originating from upstream filters and having similar concentrations of a target minor component and/or similar osmotic pressures can be mixed and subsequently filtered within additional filters. ... Massachusetts Institute Of Technology

05/19/16 / #20160136307

Nanoparticles for magnetic particle imaging applications

One method of preparing a nanoparticle can include decomposing a compound at a high temperature, adding an acid to the solvent to form a reaction mixture, increasing the temperature of the reaction mixture to boiling point of the reaction mixture, and heating the reaction mixture at the boiling point for 60 to 120 minutes to produce the nanoparticle. The coated nanoparticle or the nanoparticle can be used in magnetic particles imaging.. ... Massachusetts Institute Of Technology

05/12/16 / #20160134377

Method and apparatus for transmitting phase shift keyed optical signals

A burst-mode phase shift keying (psk) communications apparatus according to an embodiment of the present invention enables practical, power-efficient, multi-rate communications between an optical transmitter and receiver. Embodiments may operate on differential psk (dpsk) signals. ... Massachusetts Institute Of Technology

05/12/16 / #20160133297

Dynamic video summarization

Cyclical pixel-based remapping techniques are disclosed for efficiently creating and displaying a video summary. Cyclical temporal remapping at the pixel level requires less processing power and eliminates the need for object identification and tracking, allowing for dynamic adjustment of summary video parameters while a user is viewing the summary video. ... Massachusetts Institute Of Technology

05/12/16 / #20160133157

Educational building blocks to model dna and rna structures

A kit of educational building blocks models nucleic acid structures for use in teaching nucleic acid structures using building blocks that visually represent nucleotides and their components.. . ... Massachusetts Institute Of Technology

05/12/16 / #20160132787

Distributed, multi-model, self-learning platform for machine learning

A system is provided for multi-methodology, multi-user, self-optimizing machine learning as a service for that automates and optimizes the model training process. The system uses a large-scale distributed architecture and is compatible with cloud services. ... Massachusetts Institute Of Technology

05/12/16 / #20160130306

Human adaptation of h7 ha

The present invention provides, among other things, systems (e.g., comprising compositions and/or methods) for diagnosis, prophylaxis, treatment, prevention, and/or characterization of influenza transmission and/or infection. The present invention also provides methods for monitoring influenza variants for their potential to present a pandemic risk to humans.. ... Massachusetts Institute Of Technology

05/12/16 / #20160130138

Method and applications of thin-film membrane transfer

The disclosure relates to method and apparatus for micro-contact printing of micro-electromechanical systems (“mems”) in a solvent-free environment. The disclosed embodiments enable forming a composite membrane over a parylene layer and transferring the composite structure to a receiving structure to form one or more microcavities covered by the composite membrane. ... Massachusetts Institute Of Technology

05/12/16 / #20160129440

Microfluidic structures for biomedical applications

Microfluidic structures featuring substantially circular channels may be fabricated by embossing polymer sheets.. . ... Massachusetts Institute Of Technology

05/12/16 / #20160129019

Compositions, methods, and systems relating to controlled crystallization and/or nucleation of molecular species

The present invention generally relates to compositions, methods, and systems relating to controlled crystallization and/or nucleation of a molecular species. In some embodiments, the crystallization and/or nucleation of the molecular species may be controlled by tuning the surface chemistry and/or the morphology of a crystallization substrate. ... Massachusetts Institute Of Technology

05/12/16 / #20160128566

Apparatus and method of determining an eye prescription

Eye prescriptions may be determined by providing a simple, easy to use, portable device with a specially configured targeting light source that aligns the eye, mitigates accommodation, and provides accurate results. Unlike stationary, closed view autorefractors, this device typically is portable, self-usable, relatively inexpensive, enabling more widespread use across the world.. ... Massachusetts Institute Of Technology

05/05/16 / #20160121546

Methods and apparatus for hygromorphic shape control

A composite film includes a substrate that is not responsive to relative humidity, and also one or more layers of hygromorphic material. The hygromorphic material expands in response to an increase in relative humidity and contracts in response to a decrease in relative humidity. ... Massachusetts Institute Of Technology

05/05/16 / #20160121023

Materials and methods for rescue of ischemic tissue and regeneration of tissue integrity during resection, engraftment and transplantation

Cell-containing implants populated with endothelial cells rescue liver donor and recipient endothelium and parenchyma from ischemic injury after major hepatectomy and engraftment. The inventions disclosed herein highlight the discovery that endothelial-hepatocyte physiologically communicate and cooperate during hepatic repair. ... Massachusetts Institute Of Technology

05/05/16 / #20160120438

Nmr sensor and methods for rapid, non-invasive determination of hydration state or vascular volume of a subject

The invention features methods for detecting the hydration state or vascular volume of a subject using a device capable of nuclear magnetic resonance (nmr) measurement. The methods involve exposing a portion of a tissue of the subject in vivo to a magnetic field and rf pulse from the device to excite hydrogen nuclei of water within the tissue portion, and measuring a relaxation parameter of the hydrogen nuclei in the tissue portion, the relaxation parameter being a quantitative measure of the hydration state or vascular volume of the subject as a whole. ... Massachusetts Institute Of Technology

04/28/16 / #20160119798

Adaptive communication for mobile router systems

An approach to adaptively positioning a set of mobile routers to provide communication services to a set of clients makes use of estimated direction profiles of communication between routers and clients. The approach does not rely on a euclidean model in which communication characteristics (e.g., signal strength, data rate, etc.) depend on distance between communicating nodes, and does not necessarily require sampling of communication characteristics in unproductive directions in order to move the routers to preferable locations.. ... Massachusetts Institute Of Technology

04/28/16 / #20160117932

Method and apparatus for locating a target using an autonomous unmanned aerial vehicle

Described herein is an unmanned aerial vehicle (uav) system that incorporates sensor data to statistically minimize the time to autonomously locate a target on the ground. The system uses a two-stage approach to finding the rf target: 1) randomized flight, such as lévy fight, to search the ground space and, 2) a geo-localization process, such as a simplex minimization process, to home in on the target.. ... Massachusetts Institute Of Technology

04/28/16 / #20160117610

Transportation service reservation method, transportation service reservation apparatus, and computer-readable storage medium

A transportation service reservation method executes, by a computer, a process including receiving a ride request specifying an origin and a destination, generating feasible products having service types, by referring to a storage unit that stores information indicating a schedule allocated to each vehicle and the service types of the schedule, for each vehicle capable of providing products having the service types, computing a choice probability of each product forming an assortment of the feasible products, for each of assortments satisfying a predetermined condition amongst the subsets of the feasible product set that are generated, computing an expected value of a number of future ride requests, and selecting an assortment to be presented with respect to the ride request, from the assortment satisfying the predetermined condition, based on the choice probability and the expected value.. . ... Massachusetts Institute Of Technology

04/28/16 / #20160116384

Expansion microscopy

The present invention relates to an enlarged sample of interest for microscopy and methods for enlarging a sample of interest and the optical imaging of a sample of interest with resolution better than the classical microscopy diffraction limit, by synthesizing a swellable polymer network within a sample, it can be physically expanded, resulting in physical magnification.. . ... Massachusetts Institute Of Technology

04/28/16 / #20160115045

Purification of ultra-high saline and contaminated water by multi-stage ion concentration polarization (icp) desalination

A water stream is passed between two juxtaposed similar ion exchange membranes (aems or cems), forming an ion depletion and ion enrichment zones when an electric field is applied. As cations are selectively transferred through the cems, for example, anions are relocated in order to achieve electro-neutrality, resulting in the concentration drop (increase) in ion depletion (enrichment) zone. ... Massachusetts Institute Of Technology

04/28/16 / #20160114290

Methods and systems for carrying out a ph-influenced chemical and/or biological reaction

The present invention generally relates to methods and systems for carrying out a ph-influenced chemical and/or biological reaction. In some embodiments, the ph-influenced reaction involves the conversion of co2 to a dissolved species.. ... Massachusetts Institute Of Technology

04/28/16 / #20160114042

Amine-containing lipidoids and uses thereof

Provided herein are lipidoids that may be prepared from the conjugate addition of alkylamines to acrylates. In some embodiments, provided lipidoids are biodegradable and may be used in a variety of drug delivery systems. ... Massachusetts Institute Of Technology

04/07/16 / #20160098650

System for real-time optimal matching of ride sharing requests

System for optimal matching of ride sharing requests. A trip request manager receives trip requests from patrons and a shareability network is established. ... Massachusetts Institute Of Technology

04/07/16 / #20160097606

Heterogeneous surfaces

Condensation can be an important process in both emerging and traditional power generation and water desalination technologies. Superhydrophobic nanostructures can promise enhanced condensation heat transfer by reducing the characteristic size of departing droplets via a surface-tension-driven mechanism. ... Massachusetts Institute Of Technology

04/07/16 / #20160095936

Immunostimulatory compositions and methods of use thereof

Lipid conjugates for enhanced delivery of cargo to the lymph nodes are disclosed. The lipid conjugates typically include three domains: a lipophilic domain that binds to albumin, a polar block domain, and a cargo such as a molecular adjuvant or immunostimulatory compound (such as an oligonucleotide) or antigenic peptide. ... Massachusetts Institute Of Technology

03/31/16 / #20160091705

Methods and apparatus for stretched light field microscope

The information budget of a light field microscope is increased by increasing the field of view and image circle diameter of the microscope, while keeping the ratio of overall magnification of the microscope to the numerical aperture of the microscope unchanged. Alternatively, the information budget is increased by increasing the field of view and image circle diameter of the microscope by a first factor, while increasing the ratio of overall magnification of the microscope to the numerical aperture of the microscope by a smaller, second factor. ... Massachusetts Institute Of Technology

03/24/16 / #20160086707

Partial insulation superconducting magnet

The present invention is a superconducting partial insulation magnet and a method for providing the same. The magnet includes a coil with a non-insulated superconducting wire winding wound around a bobbin. ... Massachusetts Institute Of Technology

03/24/16 / #20160086080

Method and/or system for magnetic localization

A method of real time magnetic localization comprising: providing an artificial neural network field model that is calibrated and optimized for a predetermined magnet; receiving signals from one or more magnetic sensors; and solving the location of the magnet using the model based on the signals.. . ... Massachusetts Institute Of Technology

03/24/16 / #20160083783

Novel hybridization probes and uses thereof

The present invention relates to novel hybridization probes useful for rapid hybridization to realize a practicable and affordable pathogen diagnostic based on rna signature detection, technology and hardware. In particular, the present invention relates to a nucleic acid structure which may comprise nucleic acid tiles, wherein each nucleic acid tile comprises nucleic acid oligomers, wherein each nucleic acid oligomer hybridizes to each other thereby forming a nucleic acid tile.. ... Massachusetts Institute Of Technology

03/24/16 / #20160083722

Composability and design of parts for large-scale pathway engineering in yeast

Expression cassettes comprising promoter and terminator combinations are provided and can be used to tune gene expression. Synthetic yeast promoters and methods of making them also are provided.. ... Massachusetts Institute Of Technology

03/24/16 / #20160083256

Continuous process for the production of nanostructures including nanotubes

The present invention provides methods for uniform growth of nanostructures such as nanotubes (e.g., carbon nanotubes) on the surface of a substrate, wherein the long axes of the nanostructures may be substantially aligned. The nanostructures may be further processed for use in various applications, such as composite materials. ... Massachusetts Institute Of Technology

03/24/16 / #20160083063

Wingsail with adaptable flexible flap

Wingsail. The wingsail includes a substantially rigid airfoil section having a leading and a trailing edge and a flap is attached to the trailing edge through a torsion fitting having a torsional stiffness along the span of the rigid airfoil section selected to control flap deflection with respect to the rigid airfoil section under aerodynamic loading to control rolling moment of the wingsail.. ... Massachusetts Institute Of Technology

03/24/16 / #20160082331

Force-sensing net

In exemplary implementations of this invention, a basketball net or flat net measures the translational kinetic energy of a ball that passes through an aperture in the net or impacts the net. The net includes one or more electrically conductive cords, which have a resistance that varies depending on the degree to which the cord is stretched. ... Massachusetts Institute Of Technology

03/17/16 / #20160079060

Patterning of nanostructures

A technique for forming nanostructures including introducing a plurality of molecular-size scale and/or nanoscale building blocks to a region near a substrate and simultaneously scanning a pattern on the substrate with an energy beam, wherein the energy beam causes a change in at least one physical property of at least a portion of the building blocks, such that a probability of the portion of the building blocks adhering to the pattern scanned by the energy beam is increased, and wherein the building blocks adhere to the pattern to form the structure. The energy beam and at least a portion of the building blocks may interact by electrostatic interaction to form the structure.. ... Massachusetts Institute Of Technology

03/17/16 / #20160076978

Deposition and imaging of particles on planar substrates

Among other aspects, the present invention provides for the deposition of biological particles, such as cells, in a liquid, in a desired two-dimensional pattern on a planar surface of a substrate so as to permit rapid, simple, and sensitive detection of cells and/or sub-cellular components (e.g., proteins, biomarkers) disposed on the substrate. In various aspects, the systems and methods can enable reproducible high-throughput screening and/or allow for sensitive and specific detection of rare events in heterogeneous cell populations within a biological sample, with limited or no selective cell loss or sample enrichment.. ... Massachusetts Institute Of Technology

03/17/16 / #20160076778

Localized thermal management system

Localized thermal management system. The system includes an array of emitters of beams of infrared radiation mourned for rotation within a volumetric space. ... Massachusetts Institute Of Technology

03/17/16 / #20160076061

Engineering microbes and metabolic pathways for the production of ethylene glycol

The invention relates to recombinant cells and their use in the production of ethylene glycol.. . ... Massachusetts Institute Of Technology

03/17/16 / #20160075742

Human adaptation of h3 influenza

The present invention provides, among other things, technologies and methodologies for detection, treatment, and/or prevention of influenza transmission and/or infection. The present invention also provides technologies for monitoring influenza variants for their potential to present a pandemic risk to humans.. ... Massachusetts Institute Of Technology

03/17/16 / #20160075089

Methods and apparatus for additive manufacturing along user-specified toolpaths

One or more input/output devices accept user-inputted path instructions that specify a set of multiple deposition paths for an extruder to travel. An actuator actuates motion of the extruder along a trajectory that includes each of the deposition paths and also includes multiple non-deposition paths. ... Massachusetts Institute Of Technology

03/17/16 / #20160074812

Energy-efficient conductive-gap membrane distillation

Apparatus for energy-efficient conductive-gap membrane distillation includes a feed-liquid source and a distillation module. The distillation module includes a feed-liquid chamber in fluid communication with the feed-liquid source. ... Massachusetts Institute Of Technology

03/17/16 / #20160074538

Nanoparticles for magnetic resonance imaging applications

A method of preparing a coated nanoparticle can include decomposing a compound to produce a nanoparticle, oxidizing the nanoparticle to produce an oxidized nanoparticle, and coating the oxidized nanoparticle with a zwitterionic ligand to produce the coated nanoparticle. The coated nanoparticle or the nanoparticle can be used in magnetic resonance imaging.. ... Massachusetts Institute Of Technology

03/10/16 / #20160071278

Method for mapping an environment

. . A method for mapping an environment comprises moving a sensor along a path from a start location (p0) through the environment, the sensor generating a sequence of images, each image associated with a respective estimated sensor location and comprising a point cloud having a plurality of vertices, each vertex comprising an (x,y,z)-tuple and image information for the tuple. The sequence of estimated sensor locations is sampled to provide a pose graph (p) comprising a linked sequence of nodes, each corresponding to a respective estimated sensor location. ... Massachusetts Institute Of Technology

03/10/16 / #20160070254

Methods and apparatus for digital material skins

A digital material skin is made of a set of discrete units with a finite set of parts and joints. The discrete units are assembled into a layer according to a regular geometry, with each of the discrete units being reversibly connected to at least one other unit in the set. ... Massachusetts Institute Of Technology

03/10/16 / #20160070161

Illuminated 3d model

An illuminated three-dimensional model is fabricated by importing or generating a digital dataset representing the surface of a three-dimensional source surface; producing a three-dimensional model of the three-dimensional source surface from the digital dataset, wherein the three-dimensional model has a translucent or diffusive surface and a base surface; and mounting a projection device in a configuration such that distinctive patterns of light are directed from the projection device through the base surface of the three-dimensional model to selectively illuminate at least a portion of the translucent or diffusive surface of the three-dimensional model.. . ... Massachusetts Institute Of Technology

03/10/16 / #20160068899

Methods for quantitating dna using digital multiple displacment amplification

The present invention provides improved methods for detecting contamination in wga reagents as well as improved methods for quantitating nucleic acids, such as dna. The present invention relates to novel methods of quantifying nucleic acids involving whole-genome amplification (wga) reaction components and a dye molecule to detects nucleic acids and partitioning reactions to quantify nucleic acids.. ... Massachusetts Institute Of Technology

03/10/16 / #20160067250

Methods of reducing kinase inhibitor resistance

Methods, compounds and kits relating to treating cancer, reducing kinase inhibitor or resistance, and reducing or preventing diminished ectodomain shedding are described.. . ... Massachusetts Institute Of Technology

03/03/16 / #20160064788

Air secondary battery

An air secondary battery has a positive electrode to which an oxygen-containing gas is supplied, a negative electrode containing a metal active material, and an electrolytic solution through which a metal ion generated from the metal active material is transported. The positive electrode contains a composite containing a matrix and a zeolite disposed in the matrix. ... Massachusetts Institute Of Technology

03/03/16 / #20160064787

Air secondary battery

An air secondary battery has a cathode to which an oxygen-containing gas is supplied, an anode containing an active metal material, and an electrolyte interposed between the cathode and the anode. In a discharge process, metal ions are generated from the active metal material, transferred through the electrolyte, and then reacted and bonded with oxygen molecules in the oxygen-containing gas on the cathode. ... Massachusetts Institute Of Technology

03/03/16 / #20160064734

Sodium transition metal oxide electroactive compounds

Embodiments related to electroactive compounds, their methods of manufacture, and use are described. In one embodiment, an electroactive compound may include na(feax1-a)o2. ... Massachusetts Institute Of Technology

03/03/16 / #20160064539

Semiconductor structure and recess formation etch technique

A semiconductor structure has a first layer that includes a first semiconductor material and a second layer that includes a second semiconductor material. The first semiconductor material is selectively etchable over the second semiconductor material using a first etching process. ... Massachusetts Institute Of Technology

03/03/16 / #20160064156

High-performance supercapacitors based on metal nanowire yarns

An energy-storage device is formed from a first and a second yarn, each yarn including a plurality of nanowires including aluminum and/or a transition metal. An anode pad is in contact with the first yarn and a cathode pad is in contact with the second yarn. ... Massachusetts Institute Of Technology

03/03/16 / #20160060519

Highly luminescent color-selective nanocrystalline materials

A nanocrystal capable of light emission includes a nanoparticle having photoluminescence having quantum yields of greater than 30%.. . ... Massachusetts Institute Of Technology

03/03/16 / #20160058851

Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness

The invention relates to methods of protecting against chronic stress in a subject and treating stress sensitive disorders in a subject by antagonizing ghrelin or ghrelin receptor.. . ... Massachusetts Institute Of Technology

02/25/16 / #20160056309

Method and optoelectronic structure providing polysilicon photonic devices with different optical properties in different regions

Method and structural embodiments are described which provide an integrated structure using polysilicon material having different optical properties in different regions of the structure.. . ... Massachusetts Institute Of Technology

02/25/16 / #20160054520

Method and structure providing a front-end-of-line and a back-end-of-line coupled waveguides

An integrated structure and method of formation provide a lower level waveguide having a core of a first material and a higher level waveguide having a core of a second material and a coupling region for coupling the two waveguides together. The different core materials provided different coupled waveguides having different light loss characteristics.. ... Massachusetts Institute Of Technology

02/25/16 / #20160052261

Methods and apparatus for handheld inkjet printer

A handheld inkjet printer includes an inkjet print head and a tip. One or more sensors measure the position of points on a curved surface that are physically touched by the tip while the tip is moved relative to the surface. ... Massachusetts Institute Of Technology

02/18/16 / #20160046590

Sonic hedgehog modulators

Sonic hedgehog modulators and methods of use thereof are provided for.. . ... Massachusetts Institute Of Technology

02/18/16 / #20160045120

Systems and methods for spike sorting

In a system for unsupervised spike sorting, features/dimensions suitable for clustering of the recorded spike signal data are identified, and the feature space is scaled according to the computed respective importances of the various features/dimensions. Clustering is performed on the scaled feature space.. ... Massachusetts Institute Of Technology

02/11/16 / #20160044218

High-resolution surface measurement systems and methods

This disclosure provides systems, devices, and methods for capturing and measuring surface topography. This disclosure provides a high resolution retrographic sensor comprising a volume of elastomer and a thin, opaque reflective membrane. ... Massachusetts Institute Of Technology

02/11/16 / #20160043449

Recycling car batteries for perovskite solar cells

An efficient perovskite solar cells can be synthesized from used car batteries by using both the anodes and cathodes of car batteries as material sources for the synthesis of lead iodide perovskite materials.. . ... Massachusetts Institute Of Technology

02/11/16 / #20160043270

Engineered band gaps

An optoelectronic device as well as its methods of use and manufacture are disclosed. In one embodiment, an optoelectronic device includes first and second semiconducting atomically thin layers with corresponding first and second lattice directions. ... Massachusetts Institute Of Technology

02/11/16 / #20160040218

Selective purification of rna and rna-bound molecular complexes

Disclosed are methods for isolating a target nucleic molecule of interest from a sample. The methods include contacting a sample comprising a target nucleic molecule of interest with at least one single stranded nucleic acid targeting probe comprising a nucleic acid sequence between about 30 nucleotide and the length of the target nucleic acid length that hybridizes to the target nucleic molecule of interest under highly stringent hybridization conditions. ... Massachusetts Institute Of Technology

02/11/16 / #20160040212

Methods for the detection of dna-rna proximity in vivo

Disclosed is a method for detecting spatial proximity relationships between rna and dna molecules in a cell. The method includes: providing a sample of rna and dna wherein the rna and fdna have ends capable of joining to other dna and rna, respectively; joining at least one end of the fragmented rna to the end of at least one fragmented dna, to create at least one joined rna-dna hybrid molecule, wherein the join encodes the information about the proximity of the rna and dna in the cell; reverse transcribing the at least one joined rrna-dna hybrid molecule to create least one target join dna molecule that retains the information of the join, and determining the sequence of the target join thereby detecting spatial proximity relationships between rna and dna molecules in a cell.. ... Massachusetts Institute Of Technology

02/11/16 / #20160039902

Channelrhodopsin variants and uses thereof

Cschrimson light-activated ion channel polypeptides, their encoding polynucleotides, and variants thereof are provided. Methods of introducing and using cschrimson light activated ion channels and variants thereof for to alter cell activity and function are also provided.. ... Massachusetts Institute Of Technology

02/11/16 / #20160038609

Multistage nanoparticles

Multistage nanostructures, e.g., for delivery of agents such as imaging agents and therapeutic agents to tumor vasculature.. . ... Massachusetts Institute Of Technology

02/11/16 / #20160038415

Lipid vesicle compositions and methods of use

The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles comprise terminal-cysteine-bearing antigens or cysteine-modified antigens, at their surface and/or internally.. ... Massachusetts Institute Of Technology

02/04/16 / #20160034820

Systems and methods for distributed solution of optimization problems

A framework is presented for designing a class of distributed, asynchronous optimization algorithms realized as signal processing architectures utilizing various conservation principles. The architectures are specifically based on stationary conditions pertaining to primal and dual variables in a class of generally nonconvex optimization problems. ... Massachusetts Institute Of Technology

02/04/16 / #20160033212

Enhanced flow boiling heat transfer in microchannels with structured surfaces

A two-phase microchannel heat sink can be a fluid channel including a bottom wall including a superhydrophilic surface with microstructures and a side wall including a surface that is hydrophobic relative to the superhydrophilic surface of the bottom wall. When heat flux is applied to the fluid channel, a liquid film on the bottom wall is maintained and nucleation of boiling occurs only on the side wall.. ... Massachusetts Institute Of Technology

02/04/16 / #20160031931

Solid phase peptide synthesis processes and associated systems

Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. ... Massachusetts Institute Of Technology

02/04/16 / #20160031837

Compounds for inducing proliferation and differentiation of cells, and methods of use thereof

The present invention provides methods of inducing proliferation of and/or differentiating cells comprising contacting cells with compounds within the methods of the invention. The present invention further provides cells obtainable by the methods of the invention. ... Massachusetts Institute Of Technology

02/04/16 / #20160031824

Benzimidazole derivatives and uses thereof

The present invention provides novel compounds of formula (i), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and pharmaceutical compositions thereof. The present invention also provides methods and kits using the inventive compounds and pharmaceutical compositions for treating and/or preventing diseases associated with protein aggregation, such as amyloidoses (e.g., parkinson's disease and alzheimer's disease), treating and/or preventing neurodegenerative diseases, treating and/or preventing diseases associated with tar dna binding protein 43 kda, reducing or preventing protein aggregation, and/or modulating e3 ubiquitin ligase in a subject in need thereof.. ... Massachusetts Institute Of Technology

02/04/16 / #20160030598

Reaction-based fluorescent probes for detecting zinc

Disclosed are compounds and methods useful in the detection of e.g., zn2+, in vitro and in vivo. The compounds include amino acids and peptides functionalized with a moiety that binds, e.g., zn2+. ... Massachusetts Institute Of Technology

02/04/16 / #20160030360

Modified alginates for anti-fibrotic materials and applications

Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.. ... Massachusetts Institute Of Technology

02/04/16 / #20160030359

Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates

Biomedical devices for implantation with decreased pericapsular fibrotic overgrowth are disclosed. The device includes biocompatible materials and has specific characteristics that allow the device to elicit less of a fibrotic reaction after implantation than the same device lacking one or more of these characteristic that are present on the device. ... Massachusetts Institute Of Technology

01/28/16 / #20160028403

Superconducting three-terminal device and logic gates

A three-terminal device that exhibits transistor-like functionality at cryogenic temperatures may be formed from a single layer of superconducting material. A main current-carrying channel of the device may be toggled between superconducting and normal conduction states by applying a control signal to a control terminal of the device. ... Massachusetts Institute Of Technology

01/28/16 / #20160028402

Superconducting three-terminal device and logic gates

A three-terminal device that exhibits transistor-like functionality at cryogenic temperatures may be formed from a single layer of superconducting material. A main current-carrying channel of the device may be toggled between superconducting and normal conduction states by applying a control signal to a control terminal of the device. ... Massachusetts Institute Of Technology

01/28/16 / #20160024687

Confined lateral growth of crystalline germanium material

There is provided a substrate with a lower growth confinement layer disposed thereon. An upper growth confinement layer is disposed above and vertically separated from the lower growth confinement layer. ... Massachusetts Institute Of Technology

01/28/16 / #20160023403

Systems and methods of machine vision assisted additive fabrication

The present application relates generally to systems and methods for using machine vision to provide information on one or more aspects of an additive fabrication device, such as calibration parameters and/or an object formed by the device or in the process of being formed by the device. According to some aspects, a method is provided for calibrating an additive fabrication device. ... Massachusetts Institute Of Technology

01/28/16 / #20160022839

Therapeutic retroviral vectors for gene therapy

Retroviral gene therapy vectors that are optimized for erythroid specific expression and treatment of hemoglobinopathic conditions are disclosed.. . ... Massachusetts Institute Of Technology

01/28/16 / #20160022821

Biodegradable poly (beta-amino esters) and uses thereof

Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. ... Massachusetts Institute Of Technology

01/21/16 / #20160018344

Sensor and method of detecting an analyte using 19f nmr

A sensor including a fluorinated receptor can be used to identify an analyte through shift in 19f nmr resonance of the receptor when the receptor interacts with the analyte.. . ... Massachusetts Institute Of Technology

01/21/16 / #20160017794

Engine reformer systems for lower cost, smaller scale manufacturing of liquid fuels

A reformer-liquid fuel manufacturing system that utilizes an engine to generate hydrogen-rich gas is disclosed. The engine operates at very rich conditions, such as 2.5<φ<4.0. ... Massachusetts Institute Of Technology

01/21/16 / #20160017393

Directed endonucleases for repeatable nucleic acid cleavage

The invention provides compositions and methods for repeatable directed endonucleases (rdes) and methods for repeatedly, and specifically cleaving dna offset from the rde's dna recognition sequence on the target nucleic acid rather than within the dna recognition sequence. Conservation of the recognition sequence of the target nucleic acid enables for re-localization of an rde back to the dna recognition sequence for further cleavage. ... Massachusetts Institute Of Technology

01/21/16 / #20160016321

Systems and methods for compiling robotic assemblies

Systems and methods to systematize the development of machines using inexpensive, fast, and convenient fabrication processes are disclosed. In an embodiment, a robot compiler generates a fabrication system, including mechanical, electrical, and software assemblies, that can be used for assembling a robot according to a user design.. ... Massachusetts Institute Of Technology

01/14/16 / #20160014393

Methods and apparatus for virtual sensor array

A time-of-flight camera images an object around a corner or through a diffuser. In the case of imaging around a corner, light from a hidden target object reflects off a diffuse surface and travels to the camera. ... Massachusetts Institute Of Technology

01/14/16 / #20160014335

Imaging system for immersive surveillance

Security guards at big facilities, such as airports, monitor multiple screens that display images from individual surveillance cameras dispersed throughout the facility. If a guard zooms with a particular camera, he will lose image resolution, along with perspective on the surrounding area. ... Massachusetts Institute Of Technology

01/14/16 / #20160013867

Devices and techniques for integrated optical data communication

Devices and techniques for integrated optical data communication. A method of encoding symbols in an optical signal may include encoding a first symbol by injecting charge carriers, at a first rate, into a semiconductor device, such as a pin diode. ... Massachusetts Institute Of Technology

01/14/16 / #20160011175

Methods for identifying stem cells by detecting fluorescence of cells and syncytia

Methods are disclosed for the characterization of the stage of development or pathology of a tissue sample, and for identifying pluripotent metakaryotic stem cells, comprising detecting fluorescence of cells and syncytia in fixed samples treated with a non-fluorescent schiff's base reagent in the absence of extraneous or exogenously added fluorescent dyes.. . ... Massachusetts Institute Of Technology

01/14/16 / #20160011135

Devices and methods for determination of species including chemical warfare agents

The present invention generally provides devices, systems, and methods for determination of one or more analytes. The analyte may be determined by monitoring, for example, a change in an electrical, optical, or other signal of a material (e.g., sensor material) present within the device, upon exposure to the analyte. ... Massachusetts Institute Of Technology

01/14/16 / #20160010982

Laser speckle photography for surface tampering detection

In one embodiment, a method comprises projecting, from a projector, a diffused on an object. The method further includes capturing, with a first camera in a particular location, a reference image of the object while the diffused is projected on the object. ... Massachusetts Institute Of Technology

01/14/16 / #20160009657

Amine-containing lipids and uses thereof

Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. ... Massachusetts Institute Of Technology

01/14/16 / #20160007935

Methods and apparatus for measuring physiological parameters

A sensor system includes one or more gyroscopes and one or more accelerometers, for measuring subtle motions of a user's body. The system estimates physiological parameters of a user, such as heart rate, breathing rate and heart rate variability. ... Massachusetts Institute Of Technology

01/07/16 / #20160006813

Sensor platform for context-aware experimental research

A platform for context-aware experimentation includes a housing for one or more sensors for obtaining data pertaining to an on-going experiment, a communications subsystem for transmitting data obtained by the sensors, and a microcontroller for receiving data from the sensors, providing it to the communications subsystem, and possibly controlling the sensors. The housing may be a tube, which may be configured to hold a sample and may have a cap, or a waterproof package, which may have an opening to admit at least part of a sample. ... Massachusetts Institute Of Technology

01/07/16 / #20160006676

Method and apparatus for performing finite memory network coding in an arbitrary network

Techniques for performing finite memory network coding in an arbitrary network limit an amount of memory that is provided within a node of the network for the performance of network coding operations during data relay operations. When a new data packet is received by a node, the data stored within the limited amount of memory may be updated by linearly combining the new packet with the stored data. ... Massachusetts Institute Of Technology

01/07/16 / #20160006365

High-frequency, high density power factor correction conversion for universal input grid interface

A circuit includes a reconfigurable rectifier, a voltage balancer, and a pair of converters. The reconfigurable rectifier includes an ac input port and three output ports. ... Massachusetts Institute Of Technology

01/07/16 / #20160002822

Production of free-standing crystalline material layers

Herein is provided a growth structure for forming a free-standing layer of crystalline material having at least one crystallographic symmetry. The growth structure includes a host substrate and a separation layer disposed on the host substrate for growth of a layer of the crystalline material thereon. ... Massachusetts Institute Of Technology

01/07/16 / #20160002611

Methods and apparatus for cell-free microfluidic-assisted biosynthesis

A trans-disciplinary system for cell-free biosynthesis includes a cell-free transcription-translation (tx-tl) tool and modular, generalizable microfluidic architectures. Both components of the system are independently functional and are combinable into a cell-free biosynthesis platform. ... Massachusetts Institute Of Technology

01/07/16 / #20160002178

Polyamine-fatty acid derived lipidoids and uses thereof

The present disclosure provides polyamine-fatty acid derived lipidoids (e.g., compounds of formula (i) or (ii)) and methods of preparing the lipidoids. A described lipidoid includes r—c(═o)—o— moieties (where r is a lipid moiety), which may be hydrolyzed into non-toxic fatty acids. ... Massachusetts Institute Of Technology

01/07/16 / #20160000590

Intravascular device

An electronic intravascular device is placed in tight contact with vessel walls and is used for electrical stimulation and/or electrical recording of the vessel wall and surrounding target tissue. The electrodes may operate via connectors interfacing them to external hardware or may incorporate electronics to allow wireless power, information transfer, and control. ... Massachusetts Institute Of Technology

01/07/16 / #20160000463

Instrument port for minimally invasive cardiac surgery

An instrument port for introducing instruments into a surgical site, including a port body having a channel running therethrough from a proximal end to a distal end, an instrument sleeve in slidable contact with the channel, creating a gap therebetween, and fluid flow for removing emboli efficiently from the instrument port, wherein the fluid flow includes the gap is provided. A fluid flow system for use in an instrument port is provided. ... Massachusetts Institute Of Technology








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