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Mayo Foundation For Medical Education And Research patents


Recent patent applications related to Mayo Foundation For Medical Education And Research. Mayo Foundation For Medical Education And Research is listed as an Agent/Assignee. Note: Mayo Foundation For Medical Education And Research may have other listings under different names/spellings. We're not affiliated with Mayo Foundation For Medical Education And Research, we're just tracking patents.

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Assessing and treating precursor plasma cell disorders

This document relates to materials and methods in assessing and treating mammals (e.g., humans) with precursor plasma cell (pc) disorders. Materials and methods for determining if a mammal (e.g., a mammal having a precursor plasma cell disorder) has an elevated level of 2-hydroxyglutarate (2-hg) that can be used to identify the precursor plasma cell disorder as likely to progress to a pc cancer (e.g., multiple myeloma) are provided. ... Mayo Foundation For Medical Education And Research

Insulin secreting polypeptides

This document provides methods and materials related to insulin secreting polypeptides. For example, polypeptides having the ability to induce insulin secretion and methods and materials for using use such polypeptides to induce insulin secretion and to treat diabetes are provided.. ... Mayo Foundation For Medical Education And Research

Identification of immunoglobulin free light chains by mass spectrometry

This document relates to methods for identifying one or more immunoglobulin free light chains in a sample using mass spectrometry. For example, this document relates to a method for identifying one or more immunoglobulin free light chains in a sample that includes (a) providing a sample; (b) subjecting the sample to a mass spectrometry technique to obtain a mass spectrum of the sample; and (c) identifying the presence of the one or more immunoglobulin free light chains.. ... Mayo Foundation For Medical Education And Research

Methods for autologous stem cell transplantation

Materials and methods for obtaining populations of lymphocytes and administering the population of lymphocytes to a subject are disclosed herein. In particular, disclosed herein are materials and methods for predicting and improving survival based on the absolute number of natural killer cells observed in the subject after transplant.. ... Mayo Foundation For Medical Education And Research

Systems and methods for medical imaging of patients with medical implants for use in revision surgery planning

Systems and methods are provided for processing medical images to generate information useful for planning or guiding revision surgeries, designing implants for use in revisions surgeries, or generally evaluating the bone architecture of a subject. The medical images may be x-ray images, such as those acquired with a computed tomography (“ct”) system, magnetic resonance images, such as those acquired with a magnetic resonance imaging (“mri”) system, or ultrasound images, such as those acquired with an ultrasound imaging system. ... Mayo Foundation For Medical Education And Research

Biomarkers predictive of cytokine release syndrome

The present disclosure relates to the identification and use of biomarkers (e.g., analytes, analyte profiles, or markers (e.g., gene expression and/or protein expression profiles)) with clinical relevance to cytokine release syndrome (crs).. . ... Mayo Foundation For Medical Education And Research

B7-h5, a costimulatory polypeptide

B7-h5 costimulatory polypeptides, nucleic acids encoding such polypeptides, and methods for using the polypeptides and nucleic acids to enhance a t cell response are provided herein.. . ... Mayo Foundation For Medical Education And Research

Methods and materials for reducing supression of immune function

This document provides methods and materials involved in reducing suppression of immune function in mammals. For example, methods and materials for (a) identifying a mammal as having an elevated level of cd14+/dr− cells (e.g., cd14+/dr− monocytes) and (b) administering ru486 (mifepristone; or drugs with a similar functional profile) to the identified mammal under conditions that change the ratio of cd14+/hla-dr− cells to cd14+/hla-dr− cells as well as methods and materials for (a) identifying a mammal as being likely to experience an elevated level of cd14+/dr− cells (e.g., cd14+/dr− monocytes) and (b) administering ru486 (mifepristone; or drugs with a similar functional profile) to the identified mammal under conditions that reduce the degree to which the mammal develops cd14+/dr− cells are provided.. ... Mayo Foundation For Medical Education And Research

Removing senescent cells from a mixed cell population or tissue using a phosphoinositide 3-kinase (pi3k) inhibitor

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.. ... Mayo Foundation For Medical Education And Research

Integrated image reconstruction and gradient non-linearity correction with spatial support constraints for magnetic resonance imaging

A system and method for simultaneously reconstructing magnetic resonance images and correcting those imaged for gradient nonlinearity effects are provided. As opposed to conventional methods for gradient nonlinearity correction where distortion is corrected after image reconstruction is performed, the model-based method described here prospectively accounts for the effects of gradient nonlinearity during reconstruction and implements a spatial support constraint to reduce noise amplification effects.. ... Mayo Foundation For Medical Education And Research

Methods and materials for assessing immune system profiles

This document provides methods and materials involved in assessing immune system profiles. For example, methods and materials for performing flow cytometry to determine the number of cd4+ lymphocytes, cd8+ lymphocytes, regulatory t cells, b cells, nk cells, granulocytes, cd14+hla-drlo/neg g monocytes, and/or cd86+ monocytes per unit volume (e.g., cells per μl or ml) of whole blood (e.g., fresh, un-manipulated whole blood) obtained from a mammal (e.g., a human) are provided.. ... Mayo Foundation For Medical Education And Research

Vesicular stomatitis viruses

This document provides methods and materials related to vesicular stomatitis viruses. For example, vesicular stomatitis viruses, nucleic acid molecules encoding vsv polypeptides, methods for making vesicular stomatitis viruses, and methods for using vesicular stomatitis viruses to treat cancer are provided.. ... Mayo Foundation For Medical Education And Research

Targeting tgr5 to treat disease

Materials and methods for treating cholangiopathies by targeting tgr5, including materials and methods for treating cholangiopathies such as polycystic liver disease, are provided herein.. . ... Mayo Foundation For Medical Education And Research

Treating pulmonary conditions by selectively removing senescent cells from the lung using an intermittent dosing regimen

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.. ... Mayo Foundation For Medical Education And Research

08/23/18 / #20180235886

Carrier-binding agent compositions and methods of making and using the same

Described herein are compositions of binding agents and carrier proteins, and optionally at least one therapeutic agent, and methods of making and using the same, in particular, as a cancer therapeutic. Also described are lyophilized compositions of binding agents and carrier proteins, and optionally at least one therapeutic agent, and methods of making and using the same, in particular, as a cancer therapeutic.. ... Mayo Foundation For Medical Education And Research

08/16/18 / #20180231521

Immunity to folate receptors

This document provides methods and materials related to assessing immunity to folate receptors. For example, methods and materials for assessing frα immunity in a mammal are provided. ... Mayo Foundation For Medical Education And Research

08/16/18 / #20180228839

Methods and materials for producing t cells

This document provides methods and materials for producing cd8+ t cells. For example, methods and materials for using low glucose levels (e.g., from about 0.3 mm to about 0.7 mm glucose) to culture cells to produce particular populations of t cells (e.g., cd8+ t cells such as tissue resident memory t cells) are provided.. ... Mayo Foundation For Medical Education And Research

08/16/18 / #20180228491

Medical devices and methods for body conduit lengthening and anastomosis formation

Devices and methods for body conduit lengthening and anastomosis creation can be used to treat patients with a variety of health conditions. For example, among other uses, this document describes esophageal lengthening and anastomosis devices that can be used to remedy esophageal atresia in neonatal patients.. ... Mayo Foundation For Medical Education And Research

08/09/18 / #20180224448

Methods for detecting novel autoantibodies in crohn's disease

Identification of autoantibodies associated with crohn's disease useful in diagnosis and management using an innovative protein array technology, namely nucleic acid programmable protein arrays (nappa) and applications relating thereto. Overall, reactivity of igg autoantibodies was stronger than that of iga autoantibodies; however, iga autoantibodies showed greater differential reactivity between cases and controls. ... Mayo Foundation For Medical Education And Research

08/09/18 / #20180221471

Monovalent anti-cd3 adjuvants

This document provides methods and materials related to using monovalent anti-cd3 antibodies (e.g., monovalent anti-cd3 fab fragments) as adjuvants to increase the immune response produced against an antigen (e.g., a tumor associated antigen). For example, vaccine compositions containing monovalent anti-cd3γε fab fragments in combination with tumor associated antigens (e.g., tumor associated antigens having little or no immunogenicity in the absence of monovalent anti-cd3γε fab fragments) alone or in combination with adjuvants for signals two and/or three required for full activation of t cell immune function, as well as methods and materials for using monovalent anti-cd3γε fab fragments to increase the immune response produced against an antigen (e.g., a tumor associated antigen) within a mammal (e.g., a human) are provided.. ... Mayo Foundation For Medical Education And Research

08/09/18 / #20180221146

Methods for making nanofibrous coverings for implantable medical devices

Methods for making implantable medical devices with nanofibrous covering materials are described. For example, this document describes methods for making stent-like implantable medical devices with a skirt composed of nanofibrous material that is applied by an electrospinning process either directly or indirectly.. ... Mayo Foundation For Medical Education And Research

08/09/18 / #20180221026

Endoluminal anastomosis and tissue closure devices

Multiple endoscopic devices and methods for closing perforations and/or creating anastomoses in tissue are described. For example, this document provides devices and methods for performing esophagogastric anastomoses and for closing esophageal perforations in a minimally invasive fashion. ... Mayo Foundation For Medical Education And Research

08/09/18 / #20180220997

System and method for accelerated clutter filtering in ultrasound blood flow imaging using randomized ultrasound data

Described here are systems and methods for ultrasound clutter filtering to produce images of blood flow in a subject. In general, the clutter filtering is based on a singular value implementation, such as an accelerated singular value decomposition (“svd”). ... Mayo Foundation For Medical Education And Research

08/09/18 / #20180220630

Transgenic animals capable of being induced to delete senescent cells

This document relates to methods and materials involved in the removal of senescent cells within a mammal. For example, transgenic non-human animals that can be induced to delete senescent cells are provided.. ... Mayo Foundation For Medical Education And Research

08/02/18 / #20180218110

Erythropoietic stimulating agent (esa) dosage determination

An erythropoietic stimulating agent (esa) dosing system/method determines patient-specific esa therapies for patients affected by insufficient hemoglobin production that may benefit from esa treatment. The esa dosing system includes a model that represents a process by which red blood cells are produced in humans. ... Mayo Foundation For Medical Education And Research

08/02/18 / #20180215794

Treating cancer with viral nucleic acid

This document provides methods and materials related to the use of nucleic acid coding for viruses to reduce the number of viable cancer cells within a mammal. For example, methods for using infectious nucleic acid to treat cancer, engineered viral nucleic acid, methods for making engineered viral nucleic acid, methods for identifying infectious nucleic acid for treating cancer, methods and materials for controlling virus-mediated cell lysis, and methods and materials for assessing the control of virus-mediated cell lysis are provided.. ... Mayo Foundation For Medical Education And Research

08/02/18 / #20180214518

Using nucleic acids encoding nap-2 and tgf-alpha polypeptides to improve cardiac function

This document provides methods and materials for reducing the risk of major adverse cardiac events. For example, methods and materials for identifying patients at risk of experiencing a major adverse cardiac event as well as methods and material for treating patients at risk of experiencing a major adverse cardiac event (e.g., patients who underwent percutaneous coronary intervention (pci) for st-elevation myocardial infarction (stemi) are provided.. ... Mayo Foundation For Medical Education And Research

08/02/18 / #20180214497

Replication-competent vesicular stomatitis viruses

This document provides methods and materials related to vesicular stomatitis viruses. For example, replication-competent vesicular stomatitis viruses, nucleic acid molecules encoding replication-competent vesicular stomatitis viruses, methods for making replication-competent vesicular stomatitis viruses, and methods for using replication-competent vesicular stomatitis viruses to treat cancer or infectious diseases are provided.. ... Mayo Foundation For Medical Education And Research

07/19/18 / #20180203088

Systems and methods for concomitant field correction in magnetic resonance imaging with asymmetric gradients

Systems and methods for performing concomitant field corrections in magnetic resonance imaging (“mri”) systems that implement asymmetric magnetic field gradients are provided, in general, the systems and methods described here can correct for the effects of concomitant fields of multiple orders, such as zeroth order, first order, and second order concomitant fields.. . ... Mayo Foundation For Medical Education And Research

07/19/18 / #20180201684

B7-h1, a novel immunoregulatory molecule

The invention provides novel polypeptides useful for co-stimulating t cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides.. ... Mayo Foundation For Medical Education And Research

07/19/18 / #20180200294

Treating rotator cuff conditions

This document provides methods and materials related to treating rotator cuff conditions (e.g., rotator cuff tendonitis or rotator cuff injuries such as partial rotator cuff tears). For example, methods and materials for using zinc or a zinc chelator to treat rotator cuff conditions are provided.. ... Mayo Foundation For Medical Education And Research

07/19/18 / #20180200261

Methods and materials for treating cancer

This document provides methods and materials for treating cancer. For example, methods and materials for using an inhibitor of a bet polypeptide to increase the sensitivity of cancer cells to treatment with an inhibitor of a parp polypeptide are provided.. ... Mayo Foundation For Medical Education And Research

07/19/18 / #20180199971

Bone expansion devices and methods

Devices and methods for creating space within a body structure for therapeutic purposes include an expandable member disposed on the distal end portion of a catheter. Such devices and methods can be used, for example, for creating space within bone, and for injecting a filler material such as cement into the space to strengthen, repair, or otherwise enhance the bone structure.. ... Mayo Foundation For Medical Education And Research

07/12/18 / #20180193458

Compositions and methods for treating senescence-associated diseases and disorders

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders. ... Mayo Foundation For Medical Education And Research

07/05/18 / #20180187270

Methods and materials for detecting colorectal cancer and adenoma

The present invention provides methods and materials related to the detection of colorectal neoplasm-specific markers (e.g., markers associated with colorectal cancer, markers associated with adenoma) in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals (e.g., humans) having a colorectal neoplasm by detecting the presence and level of indicators of colorectal neoplasia such as, for example, long dna (e.g., quantified by alu pcr) and the presence and level of tumor-associated gene alterations (e.g., mutations in kras, apc, melanoma antigen gene, p53, braf, bat26, pik3ca) or epigenetic alterations (e.g., dna methylation) (e.g., cpg methylation) (e.g., cpg methylation in coding or regulatory regions of bmp-3, bmp-4, sfrp2, vimentin, septin9, alx4, eya4, tfpi2, ndrg4, foxe1) in dna from a stool sample obtained from the mammal.. ... Mayo Foundation For Medical Education And Research

07/05/18 / #20180187163

Mumps virus as a potential oncolytic agent

This document relates to methods and materials for virotherapy. For example, this document provides methods and materials for treating cancer using a recombinant mumps virus as an oncolytic agent.. ... Mayo Foundation For Medical Education And Research

07/05/18 / #20180187161

Differentiating induced pluripotent stem cells into glucose-responsive, insulin-secreting progeny

This document provides methods and materials related to differentiating ips cells into glucose-responsive, insulin-secreting progeny. For example, methods and material for using indolactam v (ilv) and glucagon like peptide-1 (glp-1) to produce glucose-responsive, insulin-secreting progeny from ips cells are provided.. ... Mayo Foundation For Medical Education And Research

07/05/18 / #20180186854

Treating type i and type ii diabetes

This document provides methods and materials for treating diabetes. For example, methods and materials for using nucleic acid encoding human preproinsulin to treat diabetes (e.g., type i or type ii diabetes) are provided.. ... Mayo Foundation For Medical Education And Research

07/05/18 / #20180185258

Skin care compositions

This document provides methods and materials related to skin care. For example, skin care compositions containing azelaic acid, tacrolimus, tazarotene, and zinc oxide and methods for using such skin care compositions are provided.. ... Mayo Foundation For Medical Education And Research

06/28/18 / #20180179680

Degradable scaffolding for electrospinning

Various aspects of the present disclosure are directed toward apparatuses, systems and methods that include a porous coating on a medical device. The porous coating may be formed by forming a scaffold along an exterior surface of the medical device to support the porous coating during application thereof and electrospinning a polymer to apply the porous coating on the scaffold.. ... Mayo Foundation For Medical Education And Research

06/28/18 / #20180179281

Costimulatory b7-h1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target

The invention features methods of diagnosis by assessing b7-h1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with b7-h1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of b7-h1.. . ... Mayo Foundation For Medical Education And Research

06/21/18 / #20180172712

Methods and materials for assessing hydrogen peroxide accumulation in cells

This document provides methods and materials for assessing hydrogen peroxide accumulation within cells (e.g., cancer cells) exposed to one or more test agents. For example, methods and materials for determining whether or not cancer cells (e.g., mm cells) from a mammal (e.g., a human) accumulate hydrogen peroxide following contact with a test agent (e.g., an imid) and exogenous h2o2 are provided.. ... Mayo Foundation For Medical Education And Research

06/21/18 / #20180171412

Targeted therapies for cancer

Various embodiments provide compositions and methods for detecting cancers containing an nrg1 fusion event and treating a patient with a therapeutic agent that is targeted to the nrg1 fusion. Exemplary compositions for treating cancers containing the nrg1 fusion may comprise therapeutic agents inhibiting epidermal growth factor receptor and/or erbb2 such as cetuximab, panitumumab, sym004, mm-151, mab 806, mab 528, mehd794a, gefitinib, erlotinib, lapatinib, afatinib, pd153035, ag1478, trastuzumab, and pertuzumab. ... Mayo Foundation For Medical Education And Research

06/14/18 / #20180161374

Using autologous mesenchymal stem cells to treat multiple system atrophy

This document provides methods and materials for treating multiple system atrophy in a mammal. Specifically, the methods comprises intrathecally administering to the mammal a composition comprising autologous mesenchymal stem cells (e.g. ... Mayo Foundation For Medical Education And Research

06/14/18 / #20180161347

Methods and materials for killing hiv infected cells

This document provides methods and materials involved in killing hiv infected cells (e.g., cd4 t cells). For example, methods and materials for using one or more bcl-2 inhibitors (e.g., abt-199) alone or in combination with one or more agents capable of reactivating hiv (e.g., latency reversing agent) to kill hiv infected cells (e.g., cd4 t cells) are provided.. ... Mayo Foundation For Medical Education And Research

06/07/18 / #20180156902

Shear viscosity imaging with acoustic radiation force

Shear waves are generated and measured in viscoelastic phantoms by a single push beam. Using numerical simulations or an analytical function to describe the diffraction of the shear wave, the resulting shear wave motion induced by the applied push beam is calculated with different shear elasticity values and then convolved with a separate expression that describes the effects of viscosity value for the medium. ... Mayo Foundation For Medical Education And Research

06/07/18 / #20180153994

Blocking il-9 signaling in conjunction with chemotherapy to treat cancer

This document provides methods and materials related to using inhibitors of il-9 signaling in conjunction with chemotherapy to treat cancer (e.g., solid tumors). For example, methods and materials for using inhibitors of il-9 signaling (e.g., anti-il9 antibody preparations) in conjunction with chemotherapy to treat cancer (e.g., solid tumors such as breast cancer tumors or colon cancer tumors) or to reduce the growth rate of cancer (e.g., solid tumors such as breast cancer tumors or colon cancer tumors) within a mammal are provided.. ... Mayo Foundation For Medical Education And Research

06/07/18 / #20180153698

Joint fusion instrumentation and methods

Systems and methods for joint preparation and fusion are disclosed. The system includes a cutting device having a handle, and rigid blade member. ... Mayo Foundation For Medical Education And Research

05/31/18 / #20180147209

Par1 modulation to alter myelination

Materials and methods for modulating protease activated receptor 1 (par1) activity to alter myelination are provided.. . ... Mayo Foundation For Medical Education And Research

05/31/18 / #20180147009

Thermal therapy systems and methods

Devices and methods can be used to deliver thermal therapy to treat tissue. For example, this document provides devices and methods for treating varices, varicosity, other bleeding vessels, polyps, and cancer using microwave-delivered thermal therapy in a minimally invasive fashion. ... Mayo Foundation For Medical Education And Research

05/31/18 / #20180146875

Non-invasive monitoring of physiological conditions

This document provides methods and materials related to the non-invasive measurement of analytes in blood.. . ... Mayo Foundation For Medical Education And Research

05/24/18 / #20180140429

Distal radioulnar joint prosthesis and method of use

A distal radioulnar joint prosthesis for replacing the distal radioulnar joint and a method for its implantation is provided. Such a device includes an ulnar component, a radial component, and a motion liner. ... Mayo Foundation For Medical Education And Research

05/24/18 / #20180140418

Device and methods for self-centering a guide catheter

This document provides devices and methods for the treatment of heart conditions such as valvular stenosis. For example, this document provides devices and methods by which a guide catheter can align itself with a blood flow stream to thereby help direct a guidewire or other elongate device transmitted from the guide catheter through an orifice of a heart valve.. ... Mayo Foundation For Medical Education And Research

05/24/18 / #20180140219

System and method for generating nonalcoholic fatty liver disease activity score (nas) using magnetic resonance elastography

The present disclosure relates to a system and method for non-invasively determining nafld activity scores (nas) in patients using mechanical properties determined through magnetic resonance elastography (mre) imaging. The non-invasively determined nas score is then used to diagnose nfald and nash patients.. ... Mayo Foundation For Medical Education And Research

05/17/18 / #20180133442

Hydraulic auto crossing balloon/catheter

Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for crossing a tissue region. The apparatuses, systems, and methods may include a catheter and a tip section arranged therewith. ... Mayo Foundation For Medical Education And Research

05/17/18 / #20180133211

Methods and materials for promoting bone formation

This document provides methods and materials involved in promoting new bone formation for the treatment of medical conditions such as osteoporosis, bone defects, bone injury (e.g., fractures) implant ingrowth, and joint/spine fusions. For example, methods and materials for using sulforaphane and/or ezh2 polypeptide inhibitors (e.g., gsk126 or unc1999) to treat osteoporosis, bone fractures and defects, implant ingrowth, and joint fusions are provided.. ... Mayo Foundation For Medical Education And Research

05/17/18 / #20180133159

Methods and materials for delivering agents to liver tissue

This document provides methods and materials for delivering agents to liver tissue. For example, methods and materials for using microbeads to deliver agents (e.g., chemotherapeutic agents) to liver tissue are provided.. ... Mayo Foundation For Medical Education And Research

05/17/18 / #20180132819

Intra-cardiac echocardiography with magnetic coupling

This document provides devices and methods for interventional treatment of heart conditions. For example, this document provides devices and methods that enhance intra-cardiac echocardiography visualization of interventional devices such as trans-septal puncturing needles.. ... Mayo Foundation For Medical Education And Research

05/10/18 / #20180125846

Targeted therapies for cancer

Methods of treating, and for selecting a chemotherapy regimen for treatment of cancer in a patient (fig. 9). ... Mayo Foundation For Medical Education And Research

05/03/18 / #20180119218

Spatial molecular analysis of tissue

Various methods and devices for spatial molecular analysis from tissue is provided. For example, a method of spatially mapping a tissue sample is provided with a microarray having a plurality of wells, wherein adjacent wells are separated by a shearing surface; overlaying said microarray with a tissue sample; applying a deformable substrate to an upper surface of said tissue sample; applying a force to the deformable substrate, thereby forcing underlying tissue sample into the plurality of wells; shearing the tissue sample along the shearing surface into a plurality of tissue sample islands, with each unique tissue sample island positioned in a unique well; and imaging or quantifying said plurality of tissue sample islands, thereby generating a spatial map of said tissue sample. ... Mayo Foundation For Medical Education And Research

05/03/18 / #20180119108

Methods and materials for obtaining induced pluripotent stem cells

This document provides methods and materials involved obtaining induced pluripotent stem (ips) cells. For example, methods and materials for increasing the efficiency for making ips cells as well as methods and materials for selecting ips cells are provided.. ... Mayo Foundation For Medical Education And Research

04/19/18 / #20180106815

Quantifying monoclonal antibody therapeutics by lc-ms/ms

This document relates to methods for quantifying antibody therapeutics using mass spectrometry techniques.. . ... Mayo Foundation For Medical Education And Research

04/19/18 / #20180105886

Detecting neoplasm

This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.. ... Mayo Foundation For Medical Education And Research

04/19/18 / #20180104222

Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques

Foamy macrophages with senescence markers accumulate in the subendothelial space at the onset of atherosclerosis where they drive pathology by increasing expression of key atherogenic and inflammatory cytokines and chemokines. In advanced lesions, senescent cells promote features of plaque instability, including elastic fiber degradation and fibrous cap thinning, by heightening metalloprotease production. ... Mayo Foundation For Medical Education And Research

04/19/18 / #20180103620

Methods and materials for using transgenic non-human animals expressing sodium iodide symporter polypeptides to monitor pathological processes, disease progression, or therapeutic responses over time

This document provides methods and materials for using live transgenic non-human animals (e.g., non-human mammals) to perform radiotracer imaging to monitor pathological processes, disease progression, or therapeutic responses in vivo over time. For example, methods and materials for using live transgenic non-human animals (e.g., non-human mammals) having somatic and germline cells that include nucleic acid (e.g., a transgene) having a promoter sequence operably linked to a nucleic acid sequence encoding a nis polypeptide to perform radiotracer imaging to monitor pathological processes, disease progression, or therapeutic responses in vivo over time are provided.. ... Mayo Foundation For Medical Education And Research

04/12/18 / #20180100015

Costimulatory b7-h1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target

. . The invention features methods of diagnosis by assessing b7-h1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with b7-h1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of b7-h1.. . ... Mayo Foundation For Medical Education And Research

04/12/18 / #20180099127

Surgical drain line stripping devices

Medical drain lines tend to become clogged with blood or pus and thereafter lose their efficacy. Devices can be used for stripping blockages from medical drainage lines. ... Mayo Foundation For Medical Education And Research

04/05/18 / #20180093960

Method of inhibiting apolipoprotein-e expression while increasing expression of at least one of ldl-receptor protein or abca1 protein comprising administering a small compound

This invention offers an effective method of decreasing expression of apolipoprotein e and increasing expression of at least one of either ldl-receptor protein or abca1 protein including selecting mammalian cells expressing apoe and at least one of either ldl-receptor protein or abca1 protein, contacting the mammalian cell with an effective amount of a compound having general formula (i) or general formula (ii) in an amount sufficient to decrease expression of the apoe and increase expression of at least one of the ldl-receptor protein or the abca1 protein in the mammalian cell.. . ... Mayo Foundation For Medical Education And Research

04/05/18 / #20180092922

Methods used to treat cancer

The invention encompasses methods of treating a patient with cancer, such as glioblastoma. The methods may include the administration of one or more pharmaceutical compositions that are capable of inhibiting troy to treat the patient with cancer.. ... Mayo Foundation For Medical Education And Research

04/05/18 / #20180092760

Shoulder prosthesis with variable inclination humeral head component

Methods and devices are disclosed for joint (e.g., shoulder) arthroplasty, including for reverse joint arthroplasty. In one aspect, there is provided a trial device for determining inclination, offset, and/or version of a prosthetic tray with respect to a prosthetic stem or stemless implant. ... Mayo Foundation For Medical Education And Research

04/05/18 / #20180092743

Expandable valve prosthesis with sealing mechanism

A prosthetic heart valve includes at least one sealing member. The sealing member is adapted to conform to any surface irregularities found on the inner surface of the valve annulus, including any calcium deposits formed on the valve leaflets. ... Mayo Foundation For Medical Education And Research

04/05/18 / #20180092575

Diamond-containing electrodes for neurochemical detection

This document provides methods and materials involved in assessing concentrations of analytes in an environment using a diamond-containing carbon electrode. For example, methods and materials for using fscv or paired pulse voltammetry to discriminate analytes based on their adsorption characteristics to a diamond-containing carbon electrode are described herein.. ... Mayo Foundation For Medical Education And Research

03/29/18 / #20180085383

Small molecule cd38 inhibitors and methods of using same

The invention provides methods and compositions for inhibiting cd38 activity, and methods of treating or preventing various disorders associated with cd38 activity.. . ... Mayo Foundation For Medical Education And Research

03/22/18 / #20180080921

Vitamin d deficiencies

Methods for determining the amount of vitamin d compounds in a sample are provided. The methods can employ lc-ms/ms techniques and optionally the use of deuterated internal standards. ... Mayo Foundation For Medical Education And Research

03/22/18 / #20180080085

Methods and materials for assessing and treating cancer

This document provides methods and materials involved in assessing cancer (e.g., breast cancer). For example, methods and materials for determining whether or not a cancer patient (e.g., a breast cancer patient) having er−/pgr−/her2− cancer cells is likely to have a favorable or unfavorable outcome and/or is likely to respond a cancer treatment that includes a pd-1 inhibitor and/or pd-l1 inhibitor in combination with a jak2 inhibitor are provided. ... Mayo Foundation For Medical Education And Research

03/22/18 / #20180078257

Magnetic wound closure systems

Devices, systems, and methods can be used for the closure of surgical wounds. For example, surgical wounds can be closed using magnetic closure devices rather than the conventional methods of using sutures, clips, or staples. ... Mayo Foundation For Medical Education And Research

03/15/18 / #20180075212

Medication prescribing tool

Embodiments of the disclosure include tools such as computer systems and methods that can be used by health care providers and others such as patients, pharmacists and payers to determine value optimized prescribed medication fulfillment information such as therapeutically equivalent medications and cost-effective pharmacies or other dispensing facilities for individual users. Outputs from the tools that have this information include prescription and fulfillment information, and can be, for example, in the form of reports and visual displays. ... Mayo Foundation For Medical Education And Research

03/15/18 / #20180071320

Methods and materials for treating calcific aortic valve stenosis

This document provides methods and materials involved in treating cardiovascular conditions such as calcific aortic valve stenosis. For example, methods and materials for using sgc agonists or a combination of sgc agonists and pde5a inhibitors to reduce calcification of heart valves and/or vessels or to slow progression of aortic sclerosis to calcific aortic valve stenosis are provided.. ... Mayo Foundation For Medical Education And Research

03/15/18 / #20180071106

Facet joint replacement devices

Devices and systems can be used to treating spinal conditions. For example, this document describes artificial facet joint systems that can be implanted to treat spinal conditions while facilitating normal stability and motions of the spine. ... Mayo Foundation For Medical Education And Research

03/08/18 / #20180064848

Use of resected liver serum for whole liver-engineering

The disclosure provides a method of using blood or fractions thereof, e.g., serum, obtained from a mammal subjected to liver surgery, for example, obtained following a partial hepatectomy, to increase the engraftment, proliferation and/or functionality of cells on a biocompatible scaffold.. . ... Mayo Foundation For Medical Education And Research

03/08/18 / #20180064797

Methods and materials for generating cd8+ t cells having the ability to recognize cancer cells expressing a her2/neu polypeptide

This document provides methods and materials for generating cd8− t cells having the ability to recognize cancer cells expressing a her2/neu polypeptide. For example, methods and materials for using a polypeptide consisting of an slaflpesfd amino acid sequence in vivo or in vitro to generate cd8+ t cells having the ability to recognize and lyse cancer cells expressing a her2/neu polypeptide are provided.. ... Mayo Foundation For Medical Education And Research

03/08/18 / #20180064528

Vessel dissection and harvesting apparatus, systems and methods

Apparatus, systems, and methods for endoscopic dissection of blood vessels and control over cavity pressure within an endoscopic procedure are described herein. Apparatus, systems, and methods for harvesting of blood vessels are also described herein.. ... Mayo Foundation For Medical Education And Research

03/01/18 / #20180061049

Systems and methods for analyzing in vivo tissue volumes using medical imaging data

Computer-aided methods and computer-based systems designed to elicit information from imaging data of a volume of in vivo tissue to facilitate clinical determinations and/or pathological evaluation.. . ... Mayo Foundation For Medical Education And Research

03/01/18 / #20180055645

Joint fusion instrumentation and methods

Systems and methods for joint preparation and fusion are disclosed. The system includes a cutting device having a handle, and rigid blade member. ... Mayo Foundation For Medical Education And Research

03/01/18 / #20180055476

System and method for pre-surgical breast tumor localization using non-radioactive localization material

A system and method is provided that includes a method for controlling an ultrasound detector system for localizing a marker seed at least partially composed of a piezoelectric material. The method includes arranging least one marker seed including a piezoelectric material proximate to a region of interest (roi) in a subject. ... Mayo Foundation For Medical Education And Research

02/22/18 / #20180049874

Heart valve regurgitation anchor and delivery tool

A heart valve anchor apparatus may include a body having a proximal portion and a distal portion. The body may include a first radially expandable portion at the proximal portion of the body, a second radially expandable portion at the distal portion of the body, and a root portion extending from the first radially expandable portion to the second radially expandable portion, the root portion having an outer extent. ... Mayo Foundation For Medical Education And Research

02/15/18 / #20180044295

Compounds for modulating mitochondrial function

Compounds and compositions that can modulate mitochondrial function in neuronal cells are provided herein, as are methods for using the compounds and compositions to treat or prevent conditions such as alzheimer's disease.. . ... Mayo Foundation For Medical Education And Research

02/15/18 / #20180043041

Methods for cell labeling and medical imaging

Methods of ex vivo labeling of a biological material for in vivo imaging, methods of labeling a biological material in vivo, methods for preparing a labeling agent, and methods for in vivo imaging of a subject using a biological material labeled with a labeling agent are disclosed. In one non-limiting example, the biological material is selected from cells and the labeling agent is a 89zr-desferrioxamine-ncs labeling agent.. ... Mayo Foundation For Medical Education And Research

02/08/18 / #20180038969

Methods for optimizing imaging technique parameters for photon-counting computed tomography

Described here are systems and methods for optimization techniques for automatically selecting x-ray beam spectra, energy threshold, energy bin settings, and other imaging technique parameters for photon-counting detector computed tomography (“pcct”). The techniques described here are generally based on subject or object size, material of interest, and location of the target material. ... Mayo Foundation For Medical Education And Research

02/08/18 / #20180037958

Detecting esophageal disorders

Provided herein is technology for esophageal disorder screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of esophageal disorders (e.g., barrett's esophagus, barrett's esophageal dysplasia, etc.). In addition, the technology provides methods, compositions and related uses for distinguishing between barrett's esophagus and barrett's esophageal dysplasia, and between barrett's esophageal low-grade dysplasia, barrett's esophageal high-grade dysplasia, and esophageal adenocarcinoma within samples obtained through endoscopic brushing or nonendoscopic whole esophageal brushing or swabbing using a tethered device (e.g. ... Mayo Foundation For Medical Education And Research

02/08/18 / #20180036322

Methods and materials for treating human immunodeficiency virus infections

This document provides methods and materials for treating hiv infections. For example, methods and materials for using one or more proteosome inhibitors in combination with one or more other agents to treat hiv infections are provided.. ... Mayo Foundation For Medical Education And Research

02/01/18 / #20180028795

Dissolvable dilator

Devices and methods can be used for the dilation of body conduits. For example, this document provides devices and methods for dilating a ureter using a dissolvable dilator element that is compatible with an ureteroscope system. ... Mayo Foundation For Medical Education And Research

01/25/18 / #20180021390

Prevotella histicola preparations and the treatment of autoimmune conditions

This document provides methods and materials related to prevotella histicola preparations. For example, prevotella histicola preparations in the form of an oral medicament or dietary supplement (e.g., a pill, tablet, capsule) are provided. ... Mayo Foundation For Medical Education And Research

01/25/18 / #20180021295

Methods and materials for assessing chemotherapy responsiveness and treating cancer

This document provides methods and materials involved in assessing chemotherapy responsiveness and treating cancer (e.g., breast cancer). For example, methods and materials for determining whether or not a cancer patient (e.g., a breast cancer patient) is likely to respond to chemotherapy (e.g., a taxane therapy) based at least in part on the presence of a variant in the mammal's polycystic kidney disease gene 1 (pkd1) are provided. ... Mayo Foundation For Medical Education And Research

01/11/18 / #20180010186

Estimating abdominal aortic aneurysm (aaa) expansion rate using clinical and genetic data

The present invention relates to methods of identifying and using risk factors for estimating aneurysm expansion, including high risk expansion in abdominal aortic aneurysm patients, such factors including associated genetic variants and gender differences. In particular, methods of using genetic risk scores and/or patient genotypes are provided for use, including individualizing surveillance for reducing aaa, reducing growth rates of aaa and reducing rates of aneurysm ruptures.. ... Mayo Foundation For Medical Education And Research

01/11/18 / #20180010164

Methods and materials for assessing and treating arthritis

This document provides methods and materials involved in assessing mammals (e.g., humans) for arthritis. For example, methods and materials for assessing a mammal's gut microbial diversity to identify the mammal as having arthritis (e.g., rheumatoid arthritis) are provided. ... Mayo Foundation For Medical Education And Research

01/11/18 / #20180008620

Methods of treating neurological inflammatory disorders

Methods of treating neurological inflammatory disease or seizures caused by neuroinflammation by administering cpmp are described. Treating neuroinflammatory and neurometabolic diseases with cpmp is described so as to override dyshomeostasis in the moco synthesis pathway and control synaptic inhibition in the gephyrin-gabar pathway. ... Mayo Foundation For Medical Education And Research

01/11/18 / #20180008315

Traction apparatuses and spinal traction systems

Traction apparatuses can be used to facilitate spinal surgery. For example, this document provides traction apparatuses that engage with the skull of a patient, traction apparatuses that engage with the pelvis of a patient, and cervical traction systems for use in conjunction with the skull and/or pelvis traction apparatuses to facilitate correction of occipito-cervical-thoracic deformities, and to safely position the head during spinal surgery. ... Mayo Foundation For Medical Education And Research

01/04/18 / #20180002707

Methods and materials for assembling nucleic acid constructs

This document provides methods and materials for assembling nucleic acid constructs (e.g., talens). For example, methods for assembling tales that are rapid, flexible for use in many cloning scaffolds (such as common nuclease and nickase backbones), and achievable with standard molecular biology laboratory tools, thereby making tales a more accessible genome system, are provided.. ... Mayo Foundation For Medical Education And Research

01/04/18 / #20180002416

Early marker of proteinuria in patients treated with an anti-vegf treatment

This document provides methods and materials related to determining whether or not a human receiving a therapy (e.g., an anti-vegf therapy such as a bevacizumab therapy) has developed or is at risk for developing proteinuria. For example, methods and materials for detecting urinary podocytes to determine whether or not a human receiving anti-vegf therapy has or is at risk for developing proteinuria or kidney injury are provided.. ... Mayo Foundation For Medical Education And Research

01/04/18 / #20180002290

Pyrazole derivatives as inhibitors of stat3

Compositions that modulate the activity of signal transducer and activator of transcription-3 (stat3) activity as well as their methods of use, such as treatment and imaging are provided. Compositions contain small molecules such as substituted pyrazoles and are useful in treatment of diseases related to the activity of stat3 including, for example, cancer and other diseases.. ... Mayo Foundation For Medical Education And Research

12/28/17 / #20170368241

Co2-sensing chest tube and needle thoracostomy devices

This document provides systems and methods that can improve the efficacy of tube and needle thoracostomy. For example, this document provides devices and methods for confirming the proper placement of a chest tube or needle within the pleural space to relieve a pneumothorax or tension pneumothoax.. ... Mayo Foundation For Medical Education And Research

12/28/17 / #20170368090

Methods and materials for reducing the risk of infections

This document relates to methods and materials for reducing the risk of infection after a shoulder surgery or medical procedure. For example, this document relates to methods and materials for using a topical composition containing clindamycin or erythromycin to reduce the risk of or to prevent infection associated with shoulder surgeries or medical procedures.. ... Mayo Foundation For Medical Education And Research

12/21/17 / #20170363634

Soluble b7-h1

This document features methods of evaluating mammals by assessing expression of b7-h1 in a body fluid.. . ... Mayo Foundation For Medical Education And Research

12/21/17 / #20170362595

Methods and materials for treating cancer

This document provides methods and materials for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, methods and material for using one or more inhibitors of an scd1 polypeptide to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccrcc)) or to increase the efficacy of a renal cell carcinoma treatment are provided. ... Mayo Foundation For Medical Education And Research

12/21/17 / #20170360906

Methods and materials for reducing cardiac xenograft rejection

This document provides methods and materials involved in reducing cardiac xenograft rejection. For example, methods and materials for preparing transgenic pigs expressing reduced or no endogenous sda or sda-like glycans derived from the porcine β1,4 n-acetyl-galactosaminyl transferase 2 (b4galnt2) glycosyltransferase and/or reduced or no endogenous α-gal antigens, methods and materials for modifying the xenograft recipient's immunological response to non-gal antigens (e.g. ... Mayo Foundation For Medical Education And Research

12/21/17 / #20170360290

Tube thoracostomy using an optical trocar

Systems and methods that can improve the safety and efficacy of chest tube thoracostomy are described. For example, this document provides systems and methods that facilitate direct visual confirmation of the proper placement of a chest tube within the thoracic space.. ... Mayo Foundation For Medical Education And Research

12/14/17 / #20170355754

Treatment of neonatal hypoxia including impairments or effects thereof

The invention provides methods for the treatment of neonatal hypoxia and associated white matter disease or injury, particularly in infant, including neonatal, animals, particularly periventricular leukomalacia (pvl) comprising administering one or more cns reactive antibody, particularly selected from igm12, igm22, igm42 and igm46. Compositions for use in treatment of white matter disease or injury in infants, particularly pvl are provided. ... Mayo Foundation For Medical Education And Research

12/07/17 / #20170348275

Prostacyclin compositions for regulation of fracture repair and bone formation

The present disclosure provides a prostacyclin coated implant to enhance fracture repair and bone formation comprising: an implant; and a prostacyclin coating comprising a prostacyclin compound disposed in a polymer coating the implant, wherein the prostacyclin coating releases the prostacyclin compound which enhances fracture repair and bone formation.. . ... Mayo Foundation For Medical Education And Research

12/07/17 / #20170348108

Joint fusion instrumentation and methods

Systems and methods for joint preparation and fusion are disclosed. The system includes a cutting device having a handle, and rigid blade member. ... Mayo Foundation For Medical Education And Research

11/23/17 / #20170336635

Imaging data capture and video streaming system

Systems and methods of the present invention provide for one or more server computers communicatively coupled to a network and configured to: receive an imaging data from a medical imaging device; encode a digital video data stream from the video data; transmit the digital video data stream via a wireless channel to at least one terminal output device coupled to the network, the terminal output device comprising: a camera mounted to the terminal output device comprising a lens transmitting, to the terminal output device, a view of a surgical field; and a display attached to the terminal output device and displaying the digital video data stream concurrently with the view of the surgical field.. . ... Mayo Foundation For Medical Education And Research

11/23/17 / #20170335401

Detection of lung neoplasia by analysis of methylated dna

Provided herein is technology for lung neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of lung cancer.. . ... Mayo Foundation For Medical Education And Research

11/23/17 / #20170333530

Methods and materials for reducing cysts and kidney weight in mammals with polycystic kidney disease

This document provides methods and materials for using natriuretic polypeptides to reduce the generation of kidney cysts, to reduce the number of kidney cysts, to reduce the size of kidney cysts, and/or to reduce the weight of a mammal's kidneys in mammals with polycystic kidney disease. For example, methods and materials for using natriuretic polypeptides (e.g., bnp) and/or nucleic acid encoding natriuretic polypeptides to reduce kidney cystogenesis and to reduce kidney organ to body weight ratios in mammals with mammals with polycystic kidney disease (e.g., autosomal recessive polycystic kidney disease) are provided.. ... Mayo Foundation For Medical Education And Research

11/23/17 / #20170333005

Method for ultrasound elastography through continuous vibration of an ultrasound transducer

A method for imaging an object by ultrasound elastography through continuous vibration of the ultrasound transducer is taught. An actuator directly in contact with the ultrasound transducer continuously vibrates the transducer in an axial direction, inducing shear waves in the tissue and allowing for real-time shear wave imaging. ... Mayo Foundation For Medical Education And Research

11/16/17 / #20170330354

System and method for improved energy series of images using multi-energy ct

A method for creating an energy series of images acquired using a multi-energy computed tomography (ct) imaging system having a plurality of energy bins includes acquiring, with the multi-energy ct imaging system, a series of energy data sets, where each energy data set is associated with at least one of the energy bins. The method includes producing a conglomerate image using at least a plurality of the energy data sets and, using the conglomerate image, reconstructing an energy series of images, each image in the energy series of images corresponding to at least one of the energy data sets.. ... Mayo Foundation For Medical Education And Research

11/16/17 / #20170326288

Medical reservoir level sensor

Devices can be used to detect a level of a fluid in a medical fluid reservoir. Methods for controlling the flow rate of a medical pump, and/or the occlusion amount of a medical fluid tube, that are based on the detected level of fluid in the medical reservoir can be used in a clinical setting.. ... Mayo Foundation For Medical Education And Research

11/09/17 / #20170322084

Spectrometric systems and mechanical methods for improved focus localization of time and space-varying measurements

A system and method of dynamically localizing a measurement of parameter characterizing tissue sample with waves produced by spectrometric system at multiple wavelengths and detected at a fixed location of the detector of the system. The parameter is calculated based on impulse response of the sample, reference data representing characteristics of material components of the sample, and path lengths through the sample corresponding to different wavelengths. ... Mayo Foundation For Medical Education And Research

11/09/17 / #20170319803

Double cuff tracheostomy device

This document provides devices and methods for performing tracheostomies. For example, this document provides devices and methods for performing tracheostomies using tracheostomy tubes that include a cuff at the neck opening area that can prevent or reduce the potential for air leaks.. ... Mayo Foundation For Medical Education And Research

10/26/17 / #20170309048

Computer system and method for diagnostic data display

A method for operating a computer system to generate and display multidimensional data. A set of multidimensional data points and a selected deviation range is received at a processor. ... Mayo Foundation For Medical Education And Research

10/26/17 / #20170308409

Body lumen occlusion apparatus and methods

Body lumen occlusion apparatus and methods are described.. . ... Mayo Foundation For Medical Education And Research

10/26/17 / #20170307617

Methods and materials for treating renal cell carcinoma

This document provides methods and materials related to treating renal cell carcinoma. For example, methods and materials for assessing a cancer patient (e.g., a renal cell carcinoma patient) for tumor or peritumoral tissue containing cd14+ cells and proceeding with a cancer treatment option (e.g., a renal cell carcinoma treatment option) based on the presence, absence, or level of cd14+ cells present within the tumor or peritumoral tissue are provided.. ... Mayo Foundation For Medical Education And Research

10/26/17 / #20170304624

Devices and methods for cardiac pacing and resynchronization

Devices and methods can be used for artificial cardiac pacing and/or resynchronization. For example, this document provides improved electrodes for stimulating and sensing electrical activity of the heart, and provides pacing and resynchronization systems incorporating such electrodes. ... Mayo Foundation For Medical Education And Research

10/26/17 / #20170304557

Vaccination delivery system and method

A device can be used for delivering a dose of a vaccine, medicine, medication, drug, or prescription. For example, this document describes a wearable vaccination device that plays an audible sound or musical tune for distracting or entertaining the patient while an intradermal vaccine is delivered via the patient's skin. ... Mayo Foundation For Medical Education And Research

10/26/17 / #20170304527

Wound irrigation system

This document provides devices, systems, and methods for treating patients with wounds. For example, this document provides a multi-lumen tubular device that can deliver wound irrigation, wound suction, and medicinal treatment through the lumens of the tubular device.. ... Mayo Foundation For Medical Education And Research

10/26/17 / #20170304113

Gastroduodenal balloon tubes and methods for use in localized hypothermia

Materials and methods for producing localized hypothermia in a patient (e.g., for treatment of acute pancreatitis and pancreatic cancer).. . ... Mayo Foundation For Medical Education And Research

10/26/17 / #20170304060

Joint fusion instrumentation and methods

Systems and methods for joint preparation and fusion are disclosed. The system includes a cutting device having a handle, and rigid blade member. ... Mayo Foundation For Medical Education And Research

10/26/17 / #20170303972

Joint fusion implant and methods

An implant for fusing a joint between first and second bone portions. The implant includes a screw member, and a washer polyaxially rotatable relative to the screw member. ... Mayo Foundation For Medical Education And Research

10/26/17 / #20170303938

Joint fusion instrumentation and methods

Systems and methods for joint preparation and fusion are disclosed. The system includes a cutting device having a handle, and rigid blade member. ... Mayo Foundation For Medical Education And Research

10/12/17 / #20170291952

Carrier-binding agent compositions and methods of making and using the same

Described herein are compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic. Also described are lyophilized compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic.. ... Mayo Foundation For Medical Education And Research

10/12/17 / #20170290744

Gastrointestinal feeding tubes with enhanced skin surface bumpers

Gastric and intestinal feeding tube devices and methods can be enhanced to provide better patient outcomes. For example, this document provides gastric and intestinal feeding tube devices that include an external bumper with pressure sensors and pressure indicators that facilitate usage of the feeding tube devices within an appropriate range of skin surface pressure. ... Mayo Foundation For Medical Education And Research

10/12/17 / #20170290582

Thorascopic heart valve repair method and apparatus

An instrument for performing thorascopic repair of heart valves includes a shaft for extending through the chest cavity and into a heart chamber providing access to a valve needing repair. A movable tip on the shaft is operable to capture a valve leaflet and a needle is operable to penetrate a capture valve leaflet and draw the suture therethrough. ... Mayo Foundation For Medical Education And Research

10/05/17 / #20170285034

Methods and materials for identifying and treating mammals having lung adenocarcinoma characterized by neuroendocrine differentiation

This document provides methods and materials involved in identifying mammals having lung adenocarcinoma characterized by neuroendocrine differentiation as well as methods and materials involved in treating mammals having lung adenocarcinoma characterized by neuroendocrine differentiation. For example, methods and materials for using ascl1 and ret expression levels to identify lung cancer patients having lung adenocarcinoma characterized by neuroendocrine differentiation are provided.. ... Mayo Foundation For Medical Education And Research

10/05/17 / #20170281212

Methods and devices for localizing, delineating and anchoring liver lesions for resection

This document provides methods and devices for localizing, delineating and/or anchoring lesions for resection from a solid organ (e.g., liver, breast, or pancreas). For example, this document provides devices that can be positioned within liver tissue to help delineate liver tumor tissue from normal liver tissue and to help hold liver tumor tissue in position for resection.. ... Mayo Foundation For Medical Education And Research

10/05/17 / #20170281193

Closure and ablation of body viscera and conduits

Devices and methods can be used to treat heart conditions. Some such devices include endocardial occlusion and ablation devices. ... Mayo Foundation For Medical Education And Research

10/05/17 / #20170281006

Systems and methods for assessing properties of biological tubes

A system and method is provided for measuring a mechanical property of a biological tube. The system and method operate to arrange a plurality of piezoelectric elements about the biological tube and apply a predetermined force or transduce an endogeneous or exogeneous force to the biological tube. ... Mayo Foundation For Medical Education And Research

09/28/17 / #20170275700

Methods and materials for identifying metastatic malignant skin lesions and treating skin cancer

This document provides methods and materials for identifying metastatic malignant skin lesions (e.g., malignant pigmented skin lesions). For example, methods and materials for using quantitative pcr results and correction protocols to reduce the impact of basal keratinocyte contamination on the analysis of test sample results to identify metastatic malignant skin lesions are provided. ... Mayo Foundation For Medical Education And Research

09/28/17 / #20170274211

System and method for suppressing vestibular activity of a human subject

A system for suppressing vestibular activity of a human subject includes an electronics module configured to generate one or more electrical stimulation signals. A plurality of electrodes each placed proximate a predetermined location on a head of a human subject is configured to deliver the one or more electrical stimulation signals to the predetermined location to suppress vestibular activity of the human subject.. ... Mayo Foundation For Medical Education And Research

09/14/17 / #20170260571

Methods and materials for treating endometrial cancer

This document provides methods and materials for detecting and/or treating endometrial hyperplasia and/or endometrial cancer. For example, this document provides methods and materials for identifying a female mammal as having endometrial hyperplasia and administering a therapy (e.g., hormone therapy) to the female mammal. ... Mayo Foundation For Medical Education And Research

09/14/17 / #20170260496

Cell culture media compositions for primary cells

Platelet lysate compositions and cell culture media compositions for maintaining and/or growing mammalian cells, such as mammalian endothelial cells (ecs) and mammalian endothelial progenitor cells (epcs), in particular human ecs (huecs) and human epcs (huepcs), such as primary huecs and primary huepcs, are provided. The cell culture media compositions contain a basal medium, a platelet lysate and, optionally, one or more exogenously added growth factors. ... Mayo Foundation For Medical Education And Research

09/14/17 / #20170258611

Devices and methods for forming stents in vivo

Materials and methods for generating conformable stents at sites of stenosis in bodily vessels (e.g., blood vessels) are provided herein.. . ... Mayo Foundation For Medical Education And Research

09/14/17 / #20170258521

Pericardial modification devices and methods

Devices and methods are described for the treatment of heart conditions such as heart failure with preserved ejection fraction, including diastolic heart failure, by performing a pericardial modification procedure. Intraoperative test procedures for assessing the efficacy of the pericardial modification procedure are also described.. ... Mayo Foundation For Medical Education And Research

09/07/17 / #20170253873

Polypeptide inhibitors of smad3 polypeptide activities

This document provides polypeptide inhibitors of smad3 polypeptide activities. For example, methods and materials for using polypeptides (e.g., polypeptides designed to include both a cell penetrating amino acid sequence and an amino acid segment of a sh3 domain of a snx9 polypeptide) to inhibit one or more smad3 polypeptide activities are provided. ... Mayo Foundation For Medical Education And Research

09/07/17 / #20170252482

Hip implant

Provided herein are hip implant devices and related surgical methods. The hip implants and methods can optionally be used in patients of asian descent.. ... Mayo Foundation For Medical Education And Research

09/07/17 / #20170252152

Self-centering guide catheter

An example medical device is disclosed. The device includes a tubular member having a lumen defined therein and a distal end portion, the distal end portion defining a guidewire port. ... Mayo Foundation For Medical Education And Research

08/17/17 / #20170232102

Hematologic cancer treatments

Disclosed herein are improved compositions and methods involved in treating hematologic cancers, i.e., cancers that begin in blood-forming tissue, such as the bone marrow, or in the cells of the immune system. The compositions comprise complexes containing albumin-containing nanoparticles (e.g., abraxane® nanoparticles) and antibodies. ... Mayo Foundation For Medical Education And Research

08/17/17 / #20170232072

Treating cardiovascular or renal diseases

This document provides methods and materials for treating cardiovascular and/or renal diseases. For example, aav9 vectors designed to express natriuretic polypeptides, nucleic acid molecules encoding natriuretic polypeptides, methods for making aav9 vectors, and methods for using such vectors or molecules to treat cardiovascular and/or renal diseases are provided.. ... Mayo Foundation For Medical Education And Research

08/10/17 / #20170226073

Compounds and methods for treating cancer

This document provides compounds, compositions, and methods for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, compounds, compositions, and methods for using one or more inhibitors of scd1 to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccrcc)), thyroid cancer, or liver cancer; or to increase the efficacy of treatment for the same.. ... Mayo Foundation For Medical Education And Research

08/03/17 / #20170221594

Solution target for cyclotron production of radiometals

Methods of producing and isolating 68ga, 89zr, 64cu, 63zn, 86y, 61cu, 99mtc, 45ti, 13n, 52mn, or 44sc and solution targets for use in the methods are disclosed. The methods of producing 68ga, 89zr, 64cu, 63zn, 86y, 61cu, 99mtc, 45ti, 13n, 52mn, or 44sc include irradiating a closed target system with a proton beam. ... Mayo Foundation For Medical Education And Research

08/03/17 / #20170218086

Methods and materials for treating cancer

This document provides methods and materials related to treating cancer. For example, methods and materials for using particles (e.g., nanoparticles) containing (a) one or more molecules having the ability to bind to a cancer cell (e.g., a human breast cancer cell) and (b) one or more molecules having the ability to bind to an apc (e.g., a human macrophage) to treat cancer are provided.. ... Mayo Foundation For Medical Education And Research

08/03/17 / #20170216453

Treating lymphomas

This document provides methods and materials related to treating lymphomas. For example, methods and materials relating to the use of a composition containing albumin-containing nanoparticle/antibody complexes (e.g., abraxane®/anti-cd20 polypeptide antibody complexes) to treat lymphomas are provided.. ... Mayo Foundation For Medical Education And Research








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