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Mcmaster University patents


Recent patent applications related to Mcmaster University. Mcmaster University is listed as an Agent/Assignee. Note: Mcmaster University may have other listings under different names/spellings. We're not affiliated with Mcmaster University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "M" | Mcmaster University-related inventors


Micelles for mucoadhesive drug delivery

Biocompatible block copolymer micelles for use in mucoadhesive drug delivery are provided. The micelles comprise a degradable hydrophobic polymer, a degradable synthetic hydrophilic polymer and a mucoadhesive polymer. ... Mcmaster University

Method of determining risk of an adverse cardiac event

Methods of determining the risk of an adverse cardiovascular event or death in a mammal are provided which include determining in a biological sample obtained from the mammal the level of a combination of biomarkers selected from a glucose metabolism biomarker, a heart function biomarker, a renal function biomarker and at least one biomarker of cardiac injury. A score is allotted based on the level of each biomarker, and the cumulative score is indicative of the risk of an adverse cardiovascular event.. ... Mcmaster University

Laterally-fed membrane chromatography device

A method of forming a frame around a membrane stack for a laterally-fed membrane chromatography device is provided. The method includes placing a membrane stack having one or more membrane layers on a bottom surface of body of a master mold, the body having opposed side walls and opposed end walls, the opposed side walls spaced apart by a distance greater than a length of the membrane stack, the opposed end walls spaced apart by a distance greater than a width of the membrane stack; placing a cap on the body of the master mold to enclose the membrane stack in the master mold, the cap having at least one opening for injecting a material into a space defined by the end walls of the master mold, the side walls of the master mold, end walls of the membrane stack side walls of the membrane stack, the bottom surface of the body and an inner surface of the cap; injecting the material into the space around the membrane stack; and curing the material to form a frame around the membrane stack.. ... Mcmaster University

Porous cellulosic substrates for lithium ion battery electrodes

An electrode material for an electrochemical cell is provided. The electrode includes a porous hydrophilic substrate, an electroactive material, and a binder. ... Mcmaster University

Generating induced neural progenitor cells from blood

The present disclosure provides a method of generating induced neural progenitor cells from cd34+/cd45+ blood cells using a pou domain containing gene or protein and inhibitors of smad and gsk-3β, without traversing the pluripotent state. Also provided are uses and assays of the cells produced by the methods of the disclosure.. ... Mcmaster University

Switched reluctance machine with even pole-phase index

Various embodiments are described herein for switched reluctance machine configurations. In at least one embodiment, a switched reluctance machine configured according to the teachings herein comprises a stator including a predetermined number of salient stator poles (ns), a rotor rotatably mounted with respect to the stator, with the rotor comprising a plurality of salient rotor poles, and a plurality of coils provided around the predetermined number of stator poles to form at least one phase of the switched reluctance machine, where the rotor poles and the stator poles are symmetrically disposed, and a number of rotor poles is related to 0□ and a number of phases according to: i) (ns/m)k ceil (mod(k,m)/m) number of phases, and ii) (ns/m)k ceil (mod(k,m/2)/m/2) for an even number of phases, where m is the number of phases, and k is a configuration index based on ns and m.. ... Mcmaster University

Switched reluctance machine with odd pole-phase index

Various embodiments are described herein for switched reluctance machine configurations. In at least one embodiment, a switched reluctance machine configured according to the teachings herein comprises a stator including a predetermined number of salient stator poles (ns), a rotor rotatably mounted with respect to the stator, with the rotor comprising a plurality of salient rotor poles, and a plurality of coils provided around the predetermined number of stator poles to form at least one phase of the switched reluctance machine, where the rotor poles and the stator poles are symmetrically disposed, and a number of rotor poles is related to ns and a number of phases according to: i) (ns/m)k ceil (mod (k,m)/m) for an odd number of phases, and ii) (ns/m)k ceil (mod(k,m/2)/m/2) for an even number of phases, where m is the number of phases, and k is a configuration index based on ns and m.. ... Mcmaster University

Semicontinuous divided wall distillation

A distillation column for separating components of a feed stream is described herein. The distillation column has a top end; a bottom end spaced from the top end; a set of trays dispersed along a length of the distillation column between the top end and the bottom end; and a dividing wall extending between the top end and the bottom end to divide the distillation column into a pre-fractionation zone, a top zone, a bottom zone and an outflow zone. ... Mcmaster University

Switched reluctance machine with toroidal winding

A switched reluctance machine has a stator core salient with stator poles disposed concentrically with a rotor that is salient with rotor poles. A plurality of coil windings are wound about the stator core so that a pair of windings are adjacent each of the stator poles. ... Mcmaster University

Method for diagnosing and monitoring inflammatory disease progression

Methods for diagnosing or monitoring endometriosis in a mammal are provided. The methods include the steps of determining the expression levels of bdnf, glycodelin and optionally zag, in a biological sample from the mammal, and determining that the mammal has endometriosis when the biomarker expression levels in the sample are elevated.. ... Mcmaster University

Allosteric activators for treatment of phenylketonuria

A method of restoring activity in phenylalanine hydroxylase is provided. The method comprises exposing the phenylalanine hydroxylase to shikimic acid, a functionally equivalent analogue thereof, a pharmaceutically acceptable salt of shikimic acid or analogue thereof, or combinations thereof. ... Mcmaster University

Carbon nanotube-based magnetic bio-ink and biosensors and methods of making and using

A new magnetic carbon nanotube (mcnt) biosensor ink (mbio-ink) that utilizes immobilized capture agents to detect specific target analytes via a simple current response method is presented here, expanding the applications of magnetic carbon nanotubes as biomolecule-sensing nanomaterials. The employment of a magnetic field to print the mbio-ink into electrically conductive networks facilitates its integration with an external circuit via the use of a simple electrode system. ... Mcmaster University

Uses of and methods of treatment with cystathionine

The present invention relates to uses of and methods of treatment with cystathionine. In one embodiment, cystathionine reduces the development of toxin-induced liver and/or kidney disease induced by homocystinuria and/or acute nephropathy. ... Mcmaster University

Brush amphiphilic block copolymers, and self-assembled nanoparticles therefrom

The present application relates to brush amphiphilic block copolymers comprising at least one block which is hydrophilic and at least another block which is hydrophobic. The block copolymers can be used to prepare nanoparticles for biomedical applications including delivery of pharmaceuticals and other bioactive agents. ... Mcmaster University

12/28/17 / #20170368033

Affinity based drug release formulations

The present application describes a two-step drug delivery formulation comprising a high affinity interaction between a drug conjugate and a compound, followed by introduction of a second compound with higher affinity to the drug conjugate to facilitate drug release. Delivery methods and specific interactions are also described.. ... Mcmaster University

12/14/17 / #20170356936

Enhanced system and method for conducting pca analysis on data signals

Systems and methods relating to fault detection and diagnosis. Signals received from sensors are first filtered to remove noise and are then analyzed using wavelet packet transform (wpt) based pca. ... Mcmaster University

12/07/17 / #20170349626

Chromatography device and method for filtering a solute from a fluid

A chromatography device for removing a solute from a fluid is provided. The device has a first plate having an inlet and a first channel. ... Mcmaster University

09/07/17 / #20170254068

Self-reinforced masonry blocks, walls made from self-reinforced masonry blocks, and method for making self-reinforced masonry blocks

A self-reinforced masonry block comprises a main body having opposed substantially parallel stacking surfaces and at least one tubular cell defined therethrough from one stacking surface to the other. At least one confining reinforcement is embedded in the main body to surrounding a corresponding cell. ... Mcmaster University

09/07/17 / #20170252672

Laterally-fed membrane chromatography device

A laterally-fed membrane chromatography device for removing a solute from a fluid is provided. The device has a top plate, a middle plate and a bottom plate. ... Mcmaster University

08/31/17 / #20170247746

Catalytic nucleic acid probes as microbial indicators

The disclosure relates to a method of generating catalytic nucleic acid probes useful for detecting microorganisms such as bacterial pathogens. In one embodiment, the catalytic nucleic acid probes are fluorogenic dnazymes. ... Mcmaster University

07/27/17 / #20170214252

Energy storage balancing system

The integration of the auxiliary power module (apm) functionality into non-dissipative balancing hardware of a high voltage battery or supercapacitor pack enables a more cost-effective non-dissipative balancing system while maintaining a similar complexity in topologies. The system uses state-space equations and three control problems to balance high-voltage energy storage elements and charge low voltage energy storage elements. ... Mcmaster University

07/13/17 / #20170199203

Metabolite panel for improved screening and diagnostic testing of cystic fibrosis

A novel method of diagnosing cystic fibrosis in a human subject is provided. The method includes the steps of: i) determining in a biological sample from the subject the level of one or more metabolic biomarkers; ii) comparing the level of the biomarker to a control level and determining the difference between the biomarker level and the control level; and iii) determining that the subject has cystic fibrosis or a related disorder when the difference in the level of the biomarker in the sample is statistically different from the control level.. ... Mcmaster University

05/18/17 / #20170138961

New markers for the assessment of the risk for development of a cardiovascular disorder

The present invention relates to the assessment of the risk for development of a cardiovascular disorder. It discloses the use of biochemical markers in the assessment of the risk for development of a cardiovascular disorder. ... Mcmaster University

04/27/17 / #20170117784

Double-rotor switched reluctance machine with segmented rotors

Various embodiments are described herein for a double-rotor switched reluctance machine with segmented rotors. In one example embodiment, the double-rotor switched reluctance machine comprises an interior rotor, an exterior rotor spaced from the interior rotor and concentrically disposed outside the interior rotor, and at least one stator disposed concentrically with the interior rotor and the exterior rotor. ... Mcmaster University

04/06/17 / #20170097320

Multi-segment injection-capillary electrophoresis-mass spectrometry (msi-ce-ms): a multiplexed screening platform and data workflow for chemical analysis

Various embodiments illustrating a multiplexed method for high throughput screening of ions in biological samples within a single capillary when using capillary electrophoresis mass spectrometry (ce-ms) are illustrated. The method includes sequential injection of multiple sample segments in series within a single capillary, the sample segments being separated by a spacer plug of buffer, and multiplexed analysis of the sample segments simultaneously within a single capillary electrophoresis (ce) run. ... Mcmaster University

04/06/17 / #20170096175

Method of forming deep-drawn paint film laminated sheet metal and articles made therefrom

A method for painting a complex or compound curved three-dimensional surface of a portion of an article. The method comprises providing a paint film; providing sheet metal having opposite major surfaces; laminating the paint film onto a major surface of the sheet metal to form a painted sheet metal laminate comprising a first portion and a second portion; permanently deforming the first portion of the painted sheet metal laminate into a formed portion of the article having a complex or compound curved three-dimensional shape; applying an initial force for securing the second portion of the painted sheet metal laminate during an initial stage of said permanently deforming step; and applying a later force for securing the second portion of the painted sheet metal laminate during a later stage of said permanently deforming step. ... Mcmaster University

03/16/17 / #20170071971

Combination therapy for the treatment of cancer

Described are methods and compositions for treating cancer that include a dopamine receptor (dr) antagonist such as thioridazine and a chemotherapeutic agent. Optionally, the chemotherapeutic agent is a dna synthesis inhibitor such as cytarabine or a microtubule inhibitor such as paclitaxel or docetaxel. ... Mcmaster University

01/26/17 / #20170021732

Electric generator for diesel electric locomotive

Electric generators are described herein. The electric generators include an interior machine formed of an interior rotor and an interior portion of a stator, and an exterior machine substantially concentric to the interior machine. ... Mcmaster University








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