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Merck Patent Gmbh patents (2015 archive)


Recent patent applications related to Merck Patent Gmbh. Merck Patent Gmbh is listed as an Agent/Assignee. Note: Merck Patent Gmbh may have other listings under different names/spellings. We're not affiliated with Merck Patent Gmbh, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "M" | Merck Patent Gmbh-related inventors


12/31/15 / #20150380649

Metal-ligand coordination compounds

The present invention relates to novel metal-ligand coordination compounds of the general formula t1-(a-t2)i, where t1 and t2 represent metal-ligand coordination compounds, to the use thereof in a device, and to a formulation and a device which comprise the novel compounds.. . ... Merck Patent Gmbh

12/31/15 / #20150376421

Reactive mesogen based polymer particles

This invention relates to polymer particles comprising monomer units of at least one reactive mesogen, a process for their preparation, the use of these particles for the preparation of optical, electrooptical, electronic, electrochemical, electrophotographic, electrowetting and electrophoretic displays and/or devices and security, cosmetic, decorative, and diagnostic applications, and electrophoretic fluids and displays.. . ... Merck Patent Gmbh

12/31/15 / #20150376206

Macrocyclic pyridazinone derivatives

The present invention relates to compounds of formula (i) wherein r1, r2, r3, r4, l and z have the meaning given in claim 1, and their use in the prophylaxis and treatment of diseases.. . ... Merck Patent Gmbh

12/31/15 / #20150376182

Substituted acetylene derivatives and their use as positive allosteric modulators of mglur4

The present invention relates to novel acetylene derivatives as positive allosteric modulators for modulating metabotropic glutamate receptor subtype 4 (mglur4) and/or altering glutamate level or glutamatergic signalling.. . ... Merck Patent Gmbh

12/31/15 / #20150376167

Pyridazinone-amides derivatives

The present invention relates to compounds of formula (i) wherein r1, ra, rb and z have the meaning given in claim 1, and their use in the prophylaxis and treatment of diseases.. . ... Merck Patent Gmbh

12/31/15 / #20150374687

Substituted quinoxaline derivatives and their use as positive allosteric modulators of mglur4

The present invention relates to novel quinoxaline derivatives as positive allosteric modulators for modulating metabotropic glutamate receptor subtype 4 (mglur4) and/or altering glutamate level or glutamatergic signalling.. . ... Merck Patent Gmbh

12/24/15 / #20150368226

Piperidinylcarbazoles

. . The present invention provides compounds of formula (i) for the treatment of parasitic diseases including malaria, as well as neurodegenerative diseases. Formula (i) wherein r3, r4, x and y have the meaning given in claim 1.. ... Merck Patent Gmbh

12/24/15 / #20150368188

Substituted carboxylic acid derivatives as aggrecanase inhibitors for the treatment of osteoarthritis

The present invention relates to compounds of the formula i and in particular medicaments comprising at least one compound of the formula i for use in the treatment and/or prophylaxis of physiological and/or pathophysiological states in the triggering of which adamts5 is involved, in particular for use in the treatment and/or prophylaxis of osteoarthritis, hepatocirrhosis, traumatic cartilage injuries, pain, allodynia or hyperalgesia.. . ... Merck Patent Gmbh

12/24/15 / #20150367543

Process for the production of three-dimensional patterns in plastic mouldings

The present invention relates to a process for the production of three-dimensional patterns in plastic mouldings, in particular to an injection-moulding process for the production of mouldings having a three-dimensional pattern, to the polymeric mouldings produced by means of this process, and to the use thereof, in particular for decorative purposes.. . ... Merck Patent Gmbh

12/17/15 / #20150361079

Spiro-quinazolinone derivatives and their use as positive allosteric modulators of mglur4

. . The present invention relates to novel spiro-quinazolinone derivatives as positive allosteric modulators for modulating metabotropic glutamate receptor subtype 4 (mglur4) and/or altering glutamate level or glutamatergic signalling.. . ... Merck Patent Gmbh

12/17/15 / #20150361053

2 amino-3,4-dihydrcquinazoline derivatives and the use thereof as cathepsin d inhibitors

The present invention relates to compounds of the formula (i) and in particular to medicaments comprising at least one compound of the formula (i) for use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions in the triggering of which cathepsin d is involved, in particular for use in the treatment and/or prophylaxis of osteoarthritis, traumatic cartilage injuries, arthritis, pain, allodynia or hyperalgesia.. . ... Merck Patent Gmbh

12/17/15 / #20150361046

Positive allosteric modulators of mglur3

The present invention relates to novel substituted pyridine derivatives as positive allosteric modulators for modulating metabotropic glutamate receptor subtype 3 (mglur3) and/or altering glutamate level or glutamatergic signalling.. . ... Merck Patent Gmbh

12/17/15 / #20150361037

Acylguanidines for treating osteoarthritis

The present invention relates to compounds of the formula (i) and in particular to medicaments comprising at least one compound of the formula i for use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions in the triggering of which cathepsin d is involved, in particular for use in the treatment and/or prophylaxis of osteoarthritis, traumatic cartilage injuries, arthritis, pain, allodynia or hyperalgesia.. . ... Merck Patent Gmbh

12/10/15 / #20150357508

Oxide media for gettering impurities from silicon wafers

The present invention relates to a novel process for the preparation of printable, low- to high-viscosity oxide media, and to the use thereof in the production of solar cells.. . ... Merck Patent Gmbh

12/10/15 / #20150355456

Electrowetting fluids

This invention relates to electrowetting fluids, the use of these fluids for the preparation of an electrowetting displays devices, and electrowetting display devices comprising such fluids.. . ... Merck Patent Gmbh

12/10/15 / #20150355149

Method and device for carrying out thin-layer chromatography

The invention relates to a method for carrying out thin-layer chromatography in which a liquid sample is applied to a separating layer (14), in which a mobile phase is subsequently applied to the separating layer (14) and brought into contact with the sample, and in which, after a development phase, a thin-layer chromatogram is produced, the liquid sample is taken up from a sample storage container (11, 12, 13) with the aid of an autopipette (4) using a new pipette tip (8, 9) for each sample application operation and applied to the separating layer (14). The invention further relates to a device (5) which is suitable for carrying out the method.. ... Merck Patent Gmbh

12/10/15 / #20150353575

Semiconducting polymers

The invention relates to novel polymers containing repeating units based on benzodithiophene or derivatives thereof, monomers and methods for their preparation, their use as semiconductors in organic electronic (oe) devices, especially in organic photovoltaic (opv) devices, and to oe and opv devices comprising these polymers.. . ... Merck Patent Gmbh

12/10/15 / #20150353548

2-aminopyridine compounds

The invention provides novel substituted 2-aminopyridine compounds according to formula (i), their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.. . ... Merck Patent Gmbh

12/10/15 / #20150353497

Novel quinoline derivatives and their use in neurodegenerative diseases

The present invention relates to quinoline compounds, and pharmaceutically acceptable compositions thereof, useful as antagonists of p2x7, and for the treatment of p2x7-related disorders.. . ... Merck Patent Gmbh

12/03/15 / #20150349277

Metal complexes

The present invention relates to metal complexes and to electronic devices, in particular organic electroluminescent devices, comprising these metal complexes.. . ... Merck Patent Gmbh

12/03/15 / #20150349256

Conjugated polymers

The invention relates to novel conjugated polymers containing one or more thieno[3,2-b]thiophene based polycyclic repeating units, to methods for their preparation and educts or intermediates used therein, to polymer blends, mixtures and formulations containing them, to the use of the polymers, polymer blends, mixtures and formulations as organic semiconductors in organic electronic (oe) devices, especially in organic photovoltaic (opv) devices and organic photodetectors (opd), and to oe, opv and opd devices comprising these polymers, polymer blends, mixtures or formulations.. . ... Merck Patent Gmbh

12/03/15 / #20150349035

Electronic apparatus having an oxygen ion pump

The present invention relates to an electronic apparatus which contains an electronically active material and an oxygen ion pump for removing oxygen from the apparatus. Furthermore, the present invention also relates to the use of an oxygen ion pump for removing oxygen from an electronic apparatus.. ... Merck Patent Gmbh

11/26/15 / #20150340636

Electronic device

The application relates to an electronic device comprising an emitting layer which comprises at least one emitter compound and at least two host materials. The application furthermore relates to the use of the device in displays or in lighting applications.. ... Merck Patent Gmbh

11/26/15 / #20150340627

Materials for electronic devices

The present application relates to a compound of a formula (i), (ii) or (iii). The compound can be used in an electronic device, preferably an organic electronic device.. ... Merck Patent Gmbh

11/26/15 / #20150340621

Organic electroluminescent device

The present invention relates to organic electroluminescent devices which comprise mixtures of at least two electron-conducting materials, in particular as matrix for phosphorescent emitters.. . ... Merck Patent Gmbh

11/26/15 / #20150340619

Electronic device

The present application relates to an electronic device having defined composition of the emitting layer. The application furthermore relates to the use of the device in displays or in lighting applications.. ... Merck Patent Gmbh

11/26/15 / #20150340616

Polymer comprising a thiadiazol group, the production of such polymer and its use in organic electronic devices

The present invention relates to a novel polymer comprising a thiadiazol group, the production of such a polymer, its use in organic electronic devices as well as such organic electronic devices.. . ... Merck Patent Gmbh

11/26/15 / #20150340613

Compounds for electronic devices

The present invention relates to compounds of the formula (i) and to the use thereof in organic electronic devices, and to organic electronic devices which comprise compounds of the formula (i), preferably as hole-transport materials and/or as matrix materials, in particular in combination with a further matrix material.. . ... Merck Patent Gmbh

11/26/15 / #20150340612

Uv emitters comprising a multiple bond

The invention relates to organic electroluminescent devices comprising organic compounds with a double or triple bond, to which at least one aromatic ring is bonded, as emitter compounds. The invention also relates to possible uses of said devices.. ... Merck Patent Gmbh

11/26/15 / #20150340541

Doping media for the local doping of silicon wafers

The present invention relates to a novel process for the preparation of print-able, high-viscosity oxide media, and to the use thereof in the production of solar cells.. . ... Merck Patent Gmbh

11/26/15 / #20150340518

Printable diffusion barriers for silicon wafers

The present invention relates to a novel process for the preparation of printable, high-viscosity oxide media, and to the use thereof in the production of solar cells.. . ... Merck Patent Gmbh

11/26/15 / #20150340165

Additives for dye-sensitized solar cells

The present invention relates to the use of at least one imidazol derivative of formula i or 1-(3,3,4,4,4-pentafluorobutyl)-1h-imidazole, 1-(3,3,4,4,4-pentafluorobutyl)-1,2,3-triazole or 1-(2′-thioethyl)ethylimidazole as additive in dye-sensitized solar cells and to special electrolyte formulations and a dye-sensitized solar cell comprising at least one compound of formula i or 1-(3,3,4,4,4-pentafluorobutyl)-1h-imidazole, 1-(3,3,4,4,4-pentafluorobutyl)-1,2,3-triazole or 1-(2′-thioethyl)ethylimidazole.. . ... Merck Patent Gmbh

11/26/15 / #20150337292

Method of producing secretable antibodies by expression in saccharomyces cerevisiae

The invention relates to a method for the production and non-covalent surface display of antibodies and derived fragments as well as molecule libraries based thereon on the surface of s. Cerevisiae cells. ... Merck Patent Gmbh

11/26/15 / #20150337258

Cell culture media

The present invention relates to cell culture media comprising inorganic ester derivatives of tyrosine and/or cysteine. The poor solubility of tyrosine and the often non-sufficient stability of cysteine in cell culture media is overcome by substituting them with an inorganic ester derivative, e.g. ... Merck Patent Gmbh

11/26/15 / #20150337197

Materials for organic electroluminescent devices

The present invention relates to compounds which are suitable for use in electronic devices, and to electronic devices, in particular organic electro-luminescent devices, comprising these compounds.. . ... Merck Patent Gmbh

11/26/15 / #20150336959

Electronic device

The present application relates to an electronic device comprising a heteroaromatic compound of a formula (i) as functional material, in particular as electron-transport material and as matrix material for emitter compounds.. . ... Merck Patent Gmbh

11/26/15 / #20150336215

Process for the laser treatment of coatings

The present invention relates to a process for the laser treatment of effect pigment-containing coatings, to coatings produced using this process, and to the use thereof in decorative and security products.. . ... Merck Patent Gmbh

11/19/15 / #20150333280

Metal complexes

. . The present invention relates to metal complexes and to electronic devices, in particular organic electroluminescent devices, comprising these metal complexes.. . ... Merck Patent Gmbh

11/19/15 / #20150333274

Materials for electronic devices

The present application relates to a compound of a formula (i) which contains an indenocarbazole group, a carbazole group and an electron-deficient group bonded to the indenocarbazole group. The compound is suitable for use in electronic devices, in particular in organic electroluminescent devices.. ... Merck Patent Gmbh

11/19/15 / #20150333263

Polymer comprising a naphthalene group and its use in organic electronic devices

The present application relates to novel polymers comprising a naphthalene group, the production of such polymers as well as their use in organoelectronic devices and the respective organoelectronic devices.. . ... Merck Patent Gmbh

11/19/15 / #20150329772

Materials for electronic devices

The present application relates to a compound of a formula (i), which is suitable for use as functional material in an electronic device, in particular as emitter material in an organic electroluminescent device.. . ... Merck Patent Gmbh

11/19/15 / #20150329589

Copolymers for protein precipitation

The present invention relates to the isolation of recombinant and/or biotherapeutic proteins for capture or clarification from cell culture fluid using copolymers. The copolymers used according to the process of the present invention comprise hydrophobic and anionic residues.. ... Merck Patent Gmbh

11/19/15 / #20150328316

Magnesium hydroxide carbonate as excipient in pharmaceutical preparations having improved release of active ingredient

The present invention relates to pharmaceutical formulations of active ingredients which have low solubility in aqueous solutions, having improved release of active ingredient, and to a process for the preparation thereof. In particular, these are pharmaceutical preparations in which magnesium hydroxide carbonate serves as excipient.. ... Merck Patent Gmbh

11/12/15 / #20150325793

Polymer containing aldehyde groups, reaction and crosslinking of this polymer, crosslinked polymer, and electroluminescent device comprising this polymer

. . . . . . The present invention relates to a polymer which comprises at least one structural unit which contains at least one aldehyde group, and to a process for the preparation of a crosslinkable or crosslinked polymer including a polymer which contains aldehyde groups. The present invention thus also relates to a crosslinkable polymer and a crosslinked polymer which is prepared by the process according to the invention, and to the use of this crosslinked polymer in electronic devices, in particular in organic electroluminescent devices, so-called oleds (oled=organic light emitting device).. ... Merck Patent Gmbh

11/12/15 / #20150323722

Reactive mesogens

The invention relates to reactive mesogens (rms) comprising a terphenyl group, to mixtures and formulations comprising them, to polymers obtained form such rms and rm mixtures, and the use of the rms, rm mixtures and polymers in optical or electrooptical components or devices, like optical retardation films for liquid crystal displays (lcds).. . ... Merck Patent Gmbh

11/12/15 / #20150322208

Conjugated polymers

The invention relates to novel conjugated polymers containing one or more polycyclic repeating units, to methods for their preparation and educts or intermediates used therein, to polymer blends, mixtures and formulations containing them, to the use of the polymers, polymer blends, mixtures and formulations as organic semiconductors in organic electronic (oe) devices, especially in organic photovoltaic (opv) devices and organic photodetectors (opd), and to oe, opv and opd devices comprising these polymers, polymer blends, mixtures or formulations.. . ... Merck Patent Gmbh

11/12/15 / #20150322198

Polymers containing 2,7-pyrene structural units

The present invention relates to polymers containing 2,7-pyrene structural units, to a process for the preparation thereof, and to blends and formulations comprising these polymers. The present invention furthermore relates to the use of the polymers or blends according to the invention in electronic devices and to electronic devices, in particular oleds, comprising the polymers or blends according to the invention.. ... Merck Patent Gmbh

11/12/15 / #20150322159

Methods of use of anti-cd19 antibodies with reduced immunogenicity

Anti-cd19 b4 antibodies with modified variable regions are disclosed. The modified anti-cd19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regions of the heavy chain variable region or light chain variable region, thereby to reduce a t-cell response.. ... Merck Patent Gmbh

11/12/15 / #20150322091

Organic electroluminescent device and boric acid and borinic acid derivatives used therein

The present invention relates to the use of aromatic boronic acid or borinic acid derivatives in organic electronic devices, in particular electroluminescent devices.. . ... Merck Patent Gmbh

11/05/15 / #20150318498

Metal complexes

. . . . The present invention relates to metal complexes and to electronic devices, in particular organic electroluminescent devices, comprising these metal complexes.. . ... Merck Patent Gmbh

11/05/15 / #20150318484

Materials for electronic devices

The present application relates to a compound according to formula (i), and the use thereof as a functional material in an electronic device. The compound according to formula (i) is preferably used as a hole-transporting material in an organic electroluminescence device (oled).. ... Merck Patent Gmbh

11/05/15 / #20150318478

Materials for organic electroluminescent devices

The present invention describes indenocarbazole derivatives having electron- and hole-transporting properties, in particular for use in the emission and/or charge-transport layer of electroluminescent devices or as matrix material. The invention furthermore relates to a process for the preparation of the compounds according to the invention and to electronic devices comprising same.. ... Merck Patent Gmbh

11/05/15 / #20150315473

Liquid-crystalline medium

The present application relates to a liquid-crystalline medium which is suitable for use in a guest-host system. The application furthermore relates to an lc device, preferably a device for the regulation of the passage of energy, containing the liquid-crystalline medium.. ... Merck Patent Gmbh

11/05/15 / #20150315177

Substituted quinones or analogues as colouring agents

The invention relates to protein-adhesive dyes, to the preparation thereof and to preparations comprising same, and to a method for colouring keratin-containing fibres, in particular for colouring human hair.. . ... Merck Patent Gmbh

10/29/15 / #20150310998

Cobalt complexes with tricyanoborate or dicyanoborate counter-anions for electrochemical or optoelectronic devices

The present invention relates to cobaltcomplex salts and their use as redox active species or dopant for hole transport materials in electrochemical and/or optoelectronic devices. The present invention relates additionally to electrochemical and/or optoelectronic devices comprising said salts and electrolyte formulations comprising said salts.. ... Merck Patent Gmbh

10/29/15 / #20150306002

3-hydroxy-4-oxo-4h-pyran- or 3-hydroxy-4-oxo-1,4-dihydropyridine derivatives as protein-adhesive active substances

The invention relates to the use of 4-oxo-4h-pyran or 4-oxo-1,4-dihydropyridine derivatives as protein-adhesive active compounds, in particular as skin- or hair-adhesive and/or skin- or hair-binding uv absorbers, and for the protection of the skin, of the hair or of the nails against damage caused by ultraviolet radiation, to specific 4-oxo-4h-pyran or 4-oxo-1,4-dihydropyridine derivatives, to the preparation thereof and to preparations comprising same. The invention furthermore relates to the use of the structural unit 4-oxo-4h-pyran-3-o-yl or 4-oxo-1,4-dihydropyridin-3-o-yl as linker for the functionalisation of protein-containing matrices.. ... Merck Patent Gmbh

10/22/15 / #20150303397

Inorganic barrier layers

. . . . An organic electroluminescent device the emits light in the uv and blue region of the visible spectrum, the device comprising an anode, a cathode, at least one emission layer and at least one exciton-blocking layer (exbl) between an emission layer and anode, wherein the exciton-blocking layer includes an inorganic material having a wide band gap and the use of the device in phototherapy.. . ... Merck Patent Gmbh

10/22/15 / #20150302995

Cobaltcomplex salts

The present invention relates to cobaltcomplex salts and their use as redox active species or dopant for hole transport materials in electrochemical and/or optoelectronic devices. The present invention relates additionally to electrochemical and/or optoelectronic devices comprising said salts and electrolyte formulations comprising said salts.. ... Merck Patent Gmbh

10/22/15 / #20150301368

Liquid-crystal displays and liquid-crystalline media having homeotropic alignment

The present invention relates to liquid-crystalline media (lc media) having negative or positive dielectric anisotropy comprising self-alignment additives (sams) with an at least one bifunctional or polyfunctional anchor group, which effects the homeotropic (vertical) alignment of the lc media at a surface or the cell walls of a liquid-crystal display (lc display). The invention therefore also encompasses lc displays having homeotropic alignment of the liquid-crystalline medium (lc medium) without conventional imide alignment layers. ... Merck Patent Gmbh

10/22/15 / #20150301344

Lens element

The invention provides a switchable lens element comprising an inverse lens structure formed by an isotropic material and an isotropic cover sheet wherein the resulting lens structure comprises an electrically switchable polymer stabilized blue phase lc medium having the same refractive index in its isotropic state. Furthermore, the present invention relates to the use of such a lens element in an electro-optical device i.e. ... Merck Patent Gmbh

10/22/15 / #20150299577

Liquid-crystalline medium

The application relates to a liquid-crystalline medium comprising at least one dichroic dye having a rylene structure which absorbs red light. The application furthermore relates to a device, preferably a device for the regulation of the passage of energy through a light-transmitting area, which contains the liquid-crystalline medium.. ... Merck Patent Gmbh

10/22/15 / #20150299562

Formulation in high-purity solvent for producing electronic devices

The present invention relates to a formulation with which electronic devices can be produced with improved performance with respect to operating voltage, efficiency and service life. The present invention likewise relates to a method for producing a formulation according to the invention and to a method for producing electronic devices using the formulation according to the invention. ... Merck Patent Gmbh

10/22/15 / #20150299184

Amine derivatives as potassium channel blockers

The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of kv1.3 channels found in t cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.. ... Merck Patent Gmbh

10/22/15 / #20150298097

Surface modification of porous base supports

The present invention relates to new separation materials with improved binding capacity, its manufacturing, and application, especially for binding protein a.. . ... Merck Patent Gmbh

10/22/15 / #20150297594

Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with a mek inhibitor

A pharmaceutical composition comprising 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile or a pharmaceutically acceptable salt and/or solvate thereof and n-((s)-2,3-dihydroxy-propyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide or a pharmaceutically acceptable salt and/or solvate thereof.. . ... Merck Patent Gmbh

10/01/15 / #20150280150

Bi-, tri- or tetranuclear mixed metal complexes containing group ib and iva elements for electronic devices such as oleds

. . . . . . The present invention relates to metal complexes which contain elements of group ib and iva mixed and electronic devices, in particular organic electroluminescent devices, which comprise metal complexes of this type. The compounds claimed are described by formula (1), formula (2) or formula (3), where the following applies to the symbols and indices used: m is on each occurrence, identically or differently, cu, ag or au; e is on each occurrence, identically or differently, si, ge or sn; the other variables are as defined in the claims.. ... Merck Patent Gmbh

10/01/15 / #20150280147

Aromatic aza-bicyclic compounds containing cu, ag, au, zn, al for use in electroluminescent devices

The present invention relates to metal complexes and electronic devices, in particular organic electroluminescent devices such as oleds, containing said metal complexes. The following compounds of formula (1) are claimed: m(l)n(l′)m, the compound of general formula (1) containing a sub-structure m(l)n of formula (2) and l representing a mono-anionic ligand. ... Merck Patent Gmbh

10/01/15 / #20150280133

Electronic device

The invention relates to an electronic device containing at least one compound of formula (i) or (ii) in an organic layer. The invention further relates to a method for producing the electronic device and the use of a compound of formula (i) or (ii) in an electronic device.. ... Merck Patent Gmbh

10/01/15 / #20150280128

Passivation layers for organic electronic devices

The invention generally relates to passivation layers for use in organic electronic devices, and more specifically in organic field effect transistors, to processes for preparing such passivation layers, and to organic electronic devices and organic field effect transistors encompassing such passivation layers.. . ... Merck Patent Gmbh

10/01/15 / #20150275079

Eu-activated luminophores

The invention relates to eu2+-activated phosphors, to a process for the preparation of these compounds, and to phosphor mixtures, light sources and lighting units which comprise the eu2+-activated phosphors according to the invention.. . ... Merck Patent Gmbh

10/01/15 / #20150274797

Antibody fusion proteins with a modified fcrn binding site

Disclosed are antibody fusion proteins with a modified fcrn binding site and nucleic acid molecules encoding them. The antibody fusion protein include two polypeptide chains, wherein the first polypeptide chain includes a biologically active molecule linked to at least a portion of an immunoglobulin constant region. ... Merck Patent Gmbh

10/01/15 / #20150273062

Magnesium hydroxide carbonate as carrier material in active ingredient-containing preparations

The present invention relates to solid formulations which contain at least one porous carrier and one or more functional substances in a stable mixture, and to the use thereof.. . ... Merck Patent Gmbh

09/24/15 / #20150270506

Electronic device

. . The present application relates to an electronic device comprising a hole-transport layer a, a doped hole-transport layer b and a hole-transport layer c, where hole-transport layers a, b and c are arranged between the anode and the emitting layer, and where hole-transport layer b is arranged on the cathode side of hole-transport layer a and hole-transport layer c is arranged on the cathode side of hole-transport layer b.. . ... Merck Patent Gmbh

09/24/15 / #20150270500

Metal complexes

The present invention relates to metal complexes and to electronic devices, in particular organic electroluminescent devices, comprising these metal complexes.. . ... Merck Patent Gmbh

09/24/15 / #20150270495

Materials for organic electroluminescent devices

The present invention relates to compounds according to formula (1), a method for producing these compounds and electronic devices, in particular organic electroluminescent devices containing said compounds.. . ... Merck Patent Gmbh

09/24/15 / #20150270490

Conjugated polymers

The invention relates to novel polymers containing repeating units based on benzo[2,1,3]thiadiazole-5,6-dicarboxylic acid bis-ester, monomers and methods for their preparation, their use as semiconductors in organic electronic (oe) devices, especially in organic photovoltaic (opv) devices, and to oe and opv devices comprising these polymers.. . ... Merck Patent Gmbh

09/24/15 / #20150270489

Emitter and hosts with aromatic units

The invention concerns polymers, electroluminescence devices, compositions and their use.. . ... Merck Patent Gmbh

09/24/15 / #20150270318

Method for producing organic electronic devices with bank structures, bank structures and electronic devices produced therewith

The present invention relates to a process for producing an organic electronic device, wherein a layer is selectively swelled with a swelling solvent so as to form bank structures allowing the deposition of the semiconductor material in a specific and well-defined area. The present invention further relates to bank structures, organic electronic devices and products or assemblies produced by said process.. ... Merck Patent Gmbh

09/24/15 / #20150267119

Polymerisable compounds and the use thereof in liquid-crystal displays

The present invention relates to polymerisable compounds, to processes and intermediates for the preparation thereof, to liquid-crystal (lc) media comprising them, and to the use of the polymerisable compounds and lc media for optical, electro-optical and electronic purposes, in particular in lc displays, especially in lc displays of the psa (“polymer sustained alignment”) type.. . ... Merck Patent Gmbh

09/24/15 / #20150266862

Heterocyclic compounds as nav channel inhibitors and uses thereof

The present invention relates to heterocyclic compounds, and pharmaceutically acceptable compositions thereof, useful as nav1.6 inhibitors.. . ... Merck Patent Gmbh

09/24/15 / #20150265516

Compositions containing cyclic peptides and methods of use

The invention relates generally to cyclic peptides and their use in compositions, especially topical, cosmetic and/or personal care compositions, and compositions containing said cyclic peptides.. . ... Merck Patent Gmbh

09/17/15 / #20150263297

Metal complexes

. . . . The present invention relates to metal complexes and to electronic devices, in particular organic electroluminescent devices, comprising these metal complexes.. . ... Merck Patent Gmbh

09/17/15 / #20150259538

Gold pigment

The present invention relates to a golden interference pigment which is suitable, in particular, for printing processes, to a process for the preparation of a pigment of this type, and to the use thereof. . ... Merck Patent Gmbh

09/17/15 / #20150259518

Microspheres

The present invention relates to microspheres and to their use, preferably as laser absorbing additive, and to a process for their production.. . ... Merck Patent Gmbh

09/17/15 / #20150259363

Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity

The present invention provides novel pyrimidine and pyridine compounds according to formula (i), formula (ii), formula (iii), formula (iv) and formula (v) their manufacture and use for the treatment of hyperproliferative diseases including, but not limited to, cancer, lupus, allergic disorders, sjogren's disease and rheumatoid arthritis. In preferred embodiments, the present invention describes irreversible kinase inhibitors including, but not limited to, inhibitors of bruton's tyrosine kinase.. ... Merck Patent Gmbh

09/10/15 / #20150255725

Organic semiconductors

. . . . The invention relates to novel organic semiconducting oligomers or polymers containing alkylated dithieno[2,3-d:2′,3′-d′]-s-indaceno[1,2-b:5,6-b′]dithiophene units, methods for their preparation and educts or intermediates used therein, polymers, blends, mixtures and formulations containing them, the use of the oligomers, polymers, blends, mixtures and formulations as semiconductor in organic electronic (oe) devices, especially in organic photovoltaic (opv) devices or organic photodetectors (opd), and to oe, opv and opd devices comprising these oligomers, polymers, blends, mixtures or formulations.. . ... Merck Patent Gmbh

09/10/15 / #20150255724

Materials for organic electroluminescent devices

The present invention relates to an organic composition which comprises a conjugated polymer as hole-transport compound and a doping compound. The present invention furthermore relates to the use of the composition according to the invention in organic electroluminescent devices, in particular in the so-called buffer layer of such devices. ... Merck Patent Gmbh

09/10/15 / #20150255720

Compounds for electronic devices

The present invention relates to compounds which are suitable for use in electronic devices, preferably organic electroluminescent devices.. . ... Merck Patent Gmbh

09/10/15 / #20150252265

Liquid-crystalline media having homeotropic alignment

The present invention relates to liquid-crystalline media (lc media) having negative or positive dielectric anisotropy, comprising a low-molecular-weight component and a polymerizable component. The polymerizable component comprises self-aligning, polymerizable mesogens (polymerizable self-alignment additives) which effect homeotropic (vertical) alignment of the lc media at a surface or the cell walls of a liquid-crystal display (lc display). ... Merck Patent Gmbh

09/10/15 / #20150252041

7-azaindole-2,7-naphthyridine derivative for the treatment of tumours

The compound 4-(2-methyl-1h-pyrrolo[2,3-b]pyridin-3-yl)-2,7-naphthyridin-1-ylamine and pharmaceutically usable salts and/or tautomers thereof. The use of this compound for the treatment of tumours, tumour growth, tumour metastases and/or aids.. ... Merck Patent Gmbh

09/03/15 / #20150246875

Fluorosurfactants

. . The present invention relates to novel compounds containing fluorinated end groups, to the use thereof as surface-active substances, and to compositions comprising these compounds.. . ... Merck Patent Gmbh

09/03/15 / #20150246573

Dispenser for opening a tape-like packaging

A dispenser for opening a tape like packaging comprising first and second films releasably connected to each other, forming envelopes sealed around an object, and disposed sequentially with a predetermined pitch. The dispenser comprises a space for holding a container of the packaging, a separator through which the packaging can be passed, for spreading apart and separating the films at an outlet thereof when a pulling force is acting on said first and second films, thereby opening envelopes and releasing the objects contained therein, and means for winding up separated first and second films of the tape like packaging. ... Merck Patent Gmbh

08/27/15 / #20150243914

Organic semiconductor formulations

. . . . Embodiments in accordance with the present invention relate generally to formulations for use in organic semiconductor layers of organic electronic devices, and more specifically in organic field effect transistors, to organic semiconductor layers prepared from such formulations, and to organic electronic devices and organic field effect transistors encompassing such organic semiconductor layers.. . ... Merck Patent Gmbh

08/27/15 / #20150243897

Materials for organic electroluminescence devices

The present invention relates to compounds according to formula (1) or formula (2) which are suitable for use in electronic devices, more particularly organic electroluminescence devices, and also to electronic devices which contain said compounds.. . ... Merck Patent Gmbh

08/27/15 / #20150240157

Liquid crystalline medium

The present invention relates to a liquid-crystalline medium based on a mixture of polar compounds having negative dielectric anisotropy (Δ∈), which is distinguished by the fact that it has a value for the ratio γ1/Δn2 in the range 6-45 with a clearing point of >60° c. And a Δ∈ of ≦−2.3. ... Merck Patent Gmbh

08/27/15 / #20150239637

Packaging for a product comprising at least one hygroscopic flowable solid

In packaging (1) for a product (3) comprising at least one hygroscopic flowable solid, a drying wrapping (10) made from a moisture-impermeable material which surrounds a product bag (2) filled with the product (3) is arranged in a transport container (4), and in which the desiccant (14) is arranged on an inside (11) of the drying wrapping (10) facing the product bag (2). The desiccant (14) is arranged in at least one, preferably in a plurality of desiccant bags (13). ... Merck Patent Gmbh

08/20/15 / #20150236261

Materials for electronic devices

The invention relates to a mixture containing at least two different triaryl amino compounds of formula (i). The mixture is suitable for use in an electronic device, preferably in an organic electroluminescent device, and in particular for use as a hole transport layer.. ... Merck Patent Gmbh

08/20/15 / #20150232749

Phosphorus-containing metal complexes

The present invention relates, inter alia, to metal complexes having improved solubility, to processes for the preparation of the metal complexes, to devices comprising these metal complexes and to the use of the metal complexes.. . ... Merck Patent Gmbh

08/20/15 / #20150231101

Solid pharmaceutical preparation containing levothyroxine

The invention relates to a solid pharmaceutical preparation comprising levothyroxine sodium, gelatine, citric acid and a filler. The solid pharmaceutical preparation has an improved stability.. ... Merck Patent Gmbh

08/13/15 / #20150228905

Compounds for electronic devices

The present invention relates to compounds of the formula (1), to the use thereof in electronic devices, and to electronic devices, particularly organic electroluminescence devices, comprising said compounds according to the invention, particularly as blue emitting material in an emitting layer.. . ... Merck Patent Gmbh

08/13/15 / #20150228903

Process of surface modification of dielectric structures in organic electronic devices

The invention relates to a process of modifying the surface energy of dielectric structures, like for example dielectric layers or bank structures, in organic electronic (oe) devices, more specifically in organic field effect transistors (ofets).. . ... Merck Patent Gmbh

08/13/15 / #20150228902

Formulations containing conductive polymers and use thereof in organic electronic devices

The invention relates to formulations containing doped conductive polymers, which due to outstanding hole injection characteristics and high conductivity are very suitable for use in organic electronic devices, preferably in organic electroluminescent devices, in particular in the buffer layers thereof. Thus the invention further relates to the use of the formulations according to the invention in organic electronic devices, preferably in electroluminescent devices, in particular in the buffer layers thereof.. ... Merck Patent Gmbh

08/13/15 / #20150225483

Targeted tgfß inhibition

This invention relates generally to bifunctional molecules including (a) a tgfβrii or fragment thereof capable of binding tgfβ and (b) an antibody, or antigen binding fragment thereof, that binds to an immune checkpoint protein, such as programmed death ligand 1 (pd-l1), uses of such molecules (e.g., for treating cancer), and methods of making such molecules.. . ... Merck Patent Gmbh

08/13/15 / #20150225451

Hydroxystatin derivatives for the treatment of arthrosis

The present invention relates to compounds of the formula (i) and in particular to medicaments comprising at least one compound of the formula (i) for use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions in the triggering of which cathepsin d is involved, in particular for use in the treatment and/or prophylaxis of arthrosis, traumatic cartilage injuries arthritis, pain, allodynia or hyperalgesia.. . ... Merck Patent Gmbh

08/13/15 / #20150225371

Novel pyrimidine imidazole amines as modulators of kinase activity

The invention provides novel imidazole amine compounds according to formula (i) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.. . ... Merck Patent Gmbh

08/13/15 / #20150225369

Ddr2 inhibitors for the treatment of osteoarthritis

The present invention relates to compounds of the formula i and in particular medicaments comprising at least one compound of the formula i for use in the treatment and/or prophylaxis of physiological and/or pathophysiological states in the triggering of which ddr2 is involved, in particular for use in the treatment and/or prophylaxis of osteoarthritis, hepatocirrhosis, traumatic cartilage injuries, pain, allodynia or hyperalgesia.. . ... Merck Patent Gmbh

08/13/15 / #20150225267

Electrodeionization module and apparatus

The present invention relates to an improved electrodeionization (edi) module and apparatus adapted to transfer ions present in a liquid under the influence of an electric field.. . ... Merck Patent Gmbh

08/13/15 / #20150224189

Silicon dioxide nanoparticles and the use thereof for vaccination

The invention relates to ultrasmall, monodisperse nanoparticles comprising silicon dioxide to the surface of which at least one antigen is attached. The nanoparticles can be used for the immunoprophylaxis or immunotherapy of cancer. ... Merck Patent Gmbh

08/06/15 / #20150221868

Organic semiconducting formulation

. . The invention generally relates to formulations for use in organic semiconductor layers of organic electronic devices, and more specifically in organic field effect transistors, to organic semiconductor layers prepared from such formulations, and to organic electronic devices and organic field effect transistors encompassing such organic semiconductor layers.. . ... Merck Patent Gmbh

08/06/15 / #20150219977

Electrophoretic fluids

This invention relates to electrophoretic fluids, the use of these fluids for the preparation of an electrophoretic display device, and electrophoretic displays comprising such fluids.. . ... Merck Patent Gmbh

08/06/15 / #20150218637

Genetic markers for predicting responsiveness to fgf-18 compound

This application is directed to the use of biomarkers for predicting the sensitivity to treatment with an fgf-18 compound in a patient having a cartilage disorder, such as osteoarthritis, cartilage injury, fractures affecting joint cartilage or surgical procedures with impact on joint cartilage (e.g., microfracture), in order to reduce the risk of adverse events and increase the overall benefit after therapy.. . ... Merck Patent Gmbh

08/06/15 / #20150218155

Bicyclic heteroaromatic compounds

Compounds of the formula i, in which x1, x2, x3, x4, x5, r1, r2, r3, r4, r5 and r6 have the meanings indicated in claim 1, are kinase inhibitors and can be employed, inter alia, for the treatment of tumours.. . ... Merck Patent Gmbh

07/30/15 / #20150214489

Materials for organic electroluminescent devices

. . . . The present invention relates to carbazole derivatives, in particular for use as triplet matrix materials in organic electroluminescent devices. The invention further relates to a method for producing the compounds according to the invention and to electronic devices comprising same.. ... Merck Patent Gmbh

07/30/15 / #20150210830

Surfactant mixtures

The present invention relates to novel surfactant mixtures, to the use thereof as additives, for example in preparations for surface coating, such as paints, lacquers, protective coatings and special coatings electronic or in optical applications.. . ... Merck Patent Gmbh

07/23/15 / #20150207076

Polymers of benzodithiophene and their use as organic semiconductors

. . The invention relates to novel polymers of benzodithiophene, methods and materials for their preparation, their use as semiconductors in organic electronic (oe) devices, and to oe devices comprising these polymers.. . ... Merck Patent Gmbh

07/23/15 / #20150207075

Derivatives of 2-diarylaminofluorene and organic electronic compounds containing them

The present invention relates to certain fluorenes, to the use of the compounds in an electronic device, and to an electronic device comprising at least one of these compounds. The present invention furthermore relates to a process for the preparation of the compounds and to a formulation and composition comprising one or more of the compounds.. ... Merck Patent Gmbh

07/23/15 / #20150205158

Liquid crystal display

The present invention relates to a liquid crystal (lc) display of the ffs type comprising a liquid crystal medium with negative dielectric anisotropy and a di- or multireactive polymerizable compound, and an alignment layer inducing planar alignment in the lc medium.. . ... Merck Patent Gmbh

07/23/15 / #20150203917

Prognosis biomarkers in cartilage disorders

This application is directed to the use of biomarkers for prognosing disease severity in a subject having a cartilage disorder, such as osteoarthritis, cartilage injury, fractures affecting joint cartilage or surgical procedures with impact on joint cartilage (e.g., microfracture). It also describes a method of predicting sensitivity to a drug prior to drug administration in a subject having a cartilage disorder, as well as clinical management based on the likelihood of said patients of being non-sensitive, sensitive or highly sensitive to a drug treatment.. ... Merck Patent Gmbh

07/23/15 / #20150203758

Liquid-crystalline media

The invention relates to liquid-crystalline media which can be used, in particular, for electro-optical displays having active-matrix addressing based on the ecb effect and for ips (in-plane switching) displays or ffs (fringe field switching) displays.. . ... Merck Patent Gmbh

07/23/15 / #20150203748

Process for production of phoshors

The present invention relates to a process for the preparation of a europium-doped alkaline-earth metal siliconitride or silicooxynitride having increased emission efficiency. The present invention furthermore relates to europium-doped alkaline-earth metal siliconitrides or silicooxynitrides which are obtainable by the preparation process according to the invention, and to the use of the europium-doped alkaline-earth metal siliconitrides or silicooxynitrides according to the invention as conversion phosphors. ... Merck Patent Gmbh

07/23/15 / #20150203491

Imidazo[4,5-c]quinolines as dna-pk inhibitors

The invention relates to compounds of the formulae (i) and (ii) in which r1, r2, r3, r4, r5, r8, x and m have the meaning indicated in the claims, and/or physiologically acceptable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. The compounds of the formula (i) can be used for the inhibition of serine/threonine protein kinases and for the sensitisation of cancer cells to anticancer agents and/or ionising radiation. ... Merck Patent Gmbh

07/16/15 / #20150197819

Biomarkers and methods for determining efficacy of anti-egfr antibodies in cancer therapy

The invention relates to biomarkers based on gene expression products and methods for determining the efficacy of anti-egfr antibodies in the treatment of egfr expressing cancer. The invention is further related to the prediction of sensitivity or resistance of a patient suffering from egfr expressing cancer to the treatment of said patient with a specific anti-egfr antibody. ... Merck Patent Gmbh

07/02/15 / #20150187965

Process for the production of solar cells having a local back surface field (lbsf)

. . The present invention relates to a method for producing solar cells with local back surface field (lbsf) using an alkaline etching paste which allows the back surface to be polished and the back surface edges to be insulated in a single process step.. . ... Merck Patent Gmbh

07/02/15 / #20150183790

Fused triazole derivatives as gamma secretase modulators

The present invention provides fused bicyclic triazole derivatives of formula (i) useful as gamma secretase modulators (gsm), for the treatment of alzheimer's disease and related diseases.. . ... Merck Patent Gmbh

07/02/15 / #20150182432

Phenyl ketone derivatives as self-tanning agents

The present invention relates to the use of phenyl ketone derivatives of the formula i for use as self-tanning substance or for increasing melanin synthesis, improving melanin transport and/or improving the distribution of melanin in suprabasal layers, and to preparations comprising these phenyl ketone derivatives.. . ... Merck Patent Gmbh

06/25/15 / #20150179953

Compounds and organic electroluminescent devices

. . . . . . The present invention concerns particular fluorenes, the use of the compound in an electronic device, and an electronic device containing at least one of these compounds. The present invention further concerns a method for producing the compound and a formulation and composition containing one or more of the compounds.. ... Merck Patent Gmbh

06/25/15 / #20150179940

Compounds and organic electronic devices

The present invention relates to certain fluorenes, to the use of the compounds in an electronic device, and to an electronic device comprising at least one of these compounds. The present invention furthermore relates to a process for the preparation of the compounds and to a formulation and composition comprising one or more of the compounds.. ... Merck Patent Gmbh

06/25/15 / #20150177587

Electrophoretic fluid

This invention relates to electrophoretic fluid comprising solvents, a highly absorbing dye, and charged particles of different colour, and electrophoretic display devices comprising such fluids.. . ... Merck Patent Gmbh

06/25/15 / #20150175628

Imidazo-oxadiazole and imidazo-thiadiazole derivatives

The present invention provides compounds of formula (i) used as amyloid beta lowering agent for the treatment of neurodegenerative diseases.. . ... Merck Patent Gmbh

06/25/15 / #20150175574

Ligands and their preparation

The present invention relates to secondary amines suitable for the preparation of ligands for organometallic complexes, their preparation and their use.. . ... Merck Patent Gmbh

06/18/15 / #20150171348

Metal complexes

. . The present invention relates to metal complexes and to electronic devices, in particular organic electroluminescent devices, comprising these metal complexes.. . ... Merck Patent Gmbh

06/18/15 / #20150168797

Electrophoretic fluids

This invention relates to electrophoretic fluids, the use of these fluids for the preparation of an electrophoretic display device, and electrophoretic displays comprising such fluids.. . ... Merck Patent Gmbh

06/18/15 / #20150168746

Particles for electrophoretic displays

This invention relates to particles comprising a pigment core particle encapsulated by a polymer, a process for their preparation, electrophoretic fluids comprising such particles, and electrophoretic display devices comprising such fluids.. . ... Merck Patent Gmbh

06/18/15 / #20150166949

Process for producing cell culture media

The present invention relates to an a process for manufacturing dry powder cell culture media. The preparation and usage of mixed particles generated by co-lyophilisation leads to homogenously blended cell culture media.. ... Merck Patent Gmbh

06/18/15 / #20150166892

Method of preparing a birefringent polymer film

The invention relates to a method of preparing a polymer film and to the use of such polymer film as in liquid crystal displays (lcds) or other optical or electrooptical devices, for decorative or security applications, as alignment layer or optical retardation film.. . ... Merck Patent Gmbh

06/18/15 / #20150166799

Effect pigments

The present invention relates to effect pigments based on coated, flake-form substrates, where an organic coating which contains fluoroalkyl groups and hydrophilic groups and is built up from at least one siloxane and/or at least one silane is applied to the substrate as outer layer.. . ... Merck Patent Gmbh

06/18/15 / #20150166588

Process for the preparation of perfluoroalkylcyano- or perfluoroalkylcyanofluoroborates

The invention relates to a process for the preparation of salts having perfluoroalkyltricyano- or perfluoroalkylcyanofluoroborate anions, ((per)fluoro)phenyltricyano- or ((per)fluoro)phenylcyanofluoroborate anions, phenyltricyanoborate anions which are mono- or disubstituted by perfluoroalkyl groups having 1 to 4 c atoms or phenylcyanofluoroborate anions which are mono- or disubstituted by perfluoroalkyl groups having 1 to 4 c atoms, by reaction of alkali metal trifluoroperfluoroalkylborate with trialkylsilyl cyanide and a subsequent salt-exchange reaction or by direct reaction of an organic trifluoroperfluoroalkyl borate with trialkylsilyl cyanide.. . ... Merck Patent Gmbh

06/11/15 / #20150159088

Compounds and liquid-crystalline medium

The invention relates to compounds of the formula i, and to a liquid-crystalline medium, preferably having a nematic phase and negative dielectric anisotropy, which comprises one or more compounds of formula i, defined herein, for use in an electro-optical display, particularly in an active-matrix display based on the va, ecb, palc, ffs or ips effect, and to the use of the compounds of the formula i for the stabilization of a liquid-crystalline medium which comprises one or more compounds of the formula ii and one or more compounds of the formulae iii-1 to iii-4, defined herein.. . ... Merck Patent Gmbh

06/04/15 / #20150155514

Organic electroluminescence device

The present invention relates to white-emitting organic electroluminescent devices in which the dependence of the colour point on the luminance can be adjusted specifically.. . ... Merck Patent Gmbh

06/04/15 / #20150155494

Organic electronic device comprising an organic semiconductors formulation

The invention generally relates to organic semiconductor formulations for use in organic semiconductor layers of organic electronic devices, and more specifically in organic field effect transistors, to organic semiconductor layers prepared from such formulations, and to organic electronic devices and organic field effect transistors encompassing such organic semiconductor layers.. . ... Merck Patent Gmbh

06/04/15 / #20150155491

Phenanthrene compounds for organic electronic devices

The invention relates to specific phenanthrenes, the use of the compound in an electronic device, and an electronic device containing at least one of said compounds. The invention further relates to a method for producing the compound and a formulation and composition containing one or more of the compounds.. ... Merck Patent Gmbh

06/04/15 / #20150153257

Sample preparation device

A sample preparation device, preferably for sterility testing, comprising a manifold including one or more receptacles for filtration units and at least one inlet and/or outlet port. The receptacle(s) is/are respectively provided with one or more connectors for establishing a fluid connection with mating ports of the filtration units and media containers/vials upon insertion of the same into the respective receptacles. ... Merck Patent Gmbh

06/04/15 / #20150152328

Photoactivated etching paste and its use

The improved method for the etching of transparent conductive oxide layers placed on flexible polymer substrates, hard substrates like glass or on silicon wafers comprises the use of new etching pastes, which are activated by irradiation.. . ... Merck Patent Gmbh

06/04/15 / #20150152104

7-azaindole derivatives

Compounds of the formula (i) in which r, r1, r2 and r3 have the meanings indicated in claim 1, are inhibitors of pdk1 and cell proliferation/cell vitality and can be employed for the treatment of tumours.. . ... Merck Patent Gmbh

06/04/15 / #20150152059

Solid state forms of n-((s)-2,3-dihydroxy-propyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide

The invention relates to solid state forms of n—((s)-2,3-dihydroxy-propyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide, processes for their preparation, and medical uses thereof.. . ... Merck Patent Gmbh

05/28/15 / #20150148351

Novel polymorphic forms of 3-(1--6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride salt and processes of manufacturing thereof

The present invention relates to 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride solvates and crystalline modifications thereof. The present invention further relates to processes of manufacturing these crystalline modifications as well as their use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, e.g. ... Merck Patent Gmbh

05/28/15 / #20150146155

Liquid crystal medium

The present invention relates to a liquid crystal (lc) medium, to its use for optical, electro-optical and electronic purposes, in particular in lc displays, especially in lc displays of the ps (“polymer sustained”) or psa (“polymer sustained alignment”) type, and to lc displays, especially ps or psa displays, comprising said lc medium.. . ... Merck Patent Gmbh

05/28/15 / #20150144847

Conjugated polymers

The invention relates to novel conjugated polymers containing one or more repeating units derived from indacenodibenzothiophene or dithia-dicyclopenta-dibenzothiophene, to methods for their preparation and educts or intermediates used therein, to polymer blends, mixtures and formulations containing them, to the use of the polymers, polymer blends, mixtures and formulations as organic semiconductors in organic electronic (oe) devices, especially in organic photovoltaic (opv) devices and organic photodetectors (opd), and to oe, opv and opd devices comprising these polymers, polymer blends, mixtures or formulations.. . ... Merck Patent Gmbh

05/28/15 / #20150144846

Organic semiconductor

The invention relates to novel compounds containing one or more units derived from 1,5-disubstituted-1,5-dihydro-[1,5]naphthyridine-2,6-dione, to methods for their preparation and educts or intermediates used therein, to mixtures and formulations containing them, to the use of the compounds, mixtures and formulations as organic semiconductors in organic electronic (oe) devices, especially in organic photovoltaic (opv) devices and organic photodetectors (opd), and to oe, opv and opd devices comprising these compounds, mixtures or formulations.. . ... Merck Patent Gmbh

05/21/15 / #20150141698

Process for the preparation of tris(perfluoroalkyl)phosphine oxides and bis(perfluoroalkyl)phosphinic acids

The invention relates to a method for producing tris(perfluoroalkyl)phosphine oxides and bis(perfluoroalkyl)phosphinic acids by reacting tris(perfluoroalkyl)difluorophosphorane or bis(perfluoroalkyl)trifluorophosphorane with non-metal oxides, metalloid oxides or organic compounds with basic oxygen residues.. . ... Merck Patent Gmbh

05/21/15 / #20150141626

Reducing the immunogenicity of fusion proteins

Disclosed are compositions and methods for producing fusion proteins with reduced immunogenicity. Fusion proteins of the invention include a junction region having an amino acid change that reduces the ability of a junctional epitope to bind to mhc class ii, thereby reducing its interaction with a t-cell receptor. ... Merck Patent Gmbh

05/21/15 / #20150140123

Protein expression analyses for identifying genotoxic compounds

The invention relates to a method for screening compounds with (pro-)genotoxic activity by providing a system being capable of expressing a panel of defined proteins, incubating at least a portion of the system with compounds to be screened, and comparing the expression of the proteins in the system with the protein expression in a control system, thereby detecting the (pro-)genotoxic activity. Another object of the invention concerns a method for monitoring the likelihood of developing a physiological and/or pathological condition, which is caused, mediated and/or propagated by the genetic deregulation of proliferation, differentiation and/or damage repair, in response to a compound administered to a mammal in need of such treatment by determining an expression level of defined proteins in a biological sample withdrawn from the mammal. ... Merck Patent Gmbh

05/21/15 / #20150140024

Variants of group 5 allergens of the true grasses having reduced allergeneity due to mutagenesis of proline residues

The present invention relates to the preparation and use of recombinant variants of group 5 allergens of the poaceae (true grasses), which are characterised by reduced ige reactivity compared with known wild-type allergens and at the same time substantially retained reactivity with t-lymphocytes.. . ... Merck Patent Gmbh

05/21/15 / #20150139922

Extracts of darlingtonia californica

The present invention relates to an extract from plant parts of darlingtonia californica, to a process for the preparation thereof, to the use of the extract in cosmetic or dermatological preparations and as self-tanning agent, and to preparations comprising an extract from plant parts of darlingtonia californica and the preparation thereof.. . ... Merck Patent Gmbh

05/07/15 / #20150126680

Particles for electrophoretic displays

This invention relates to particles comprising a core particle and a polymeric shell, a process for their preparation, electrophoretic fluids comprising such particles, and electrophoretic display devices comprising such fluids.. . ... Merck Patent Gmbh

05/07/15 / #20150126484

Aminopyrimidine derivatives for use as modulators of kinase activity

The invention provides novel heterocyclic amine compounds according to formula (i) and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.. . ... Merck Patent Gmbh

05/07/15 / #20150123049

Particles for electrophoretic displays

This invention relates to particles for electrophoretic displays, a process for their preparation, electrophoretic fluids comprising such particles, and electrophoretic display devices comprising such fluids.. . ... Merck Patent Gmbh

04/30/15 / #20150118172

Use of dicyclohexylmethanol derivatives having antimicrobial properties

The present invention relates to the use of at least one dicyclohexylmethanol derivative of the formula (i) as antimicrobial active compound or as anti-acne, antidandruff, deodorant or antiperspirant active compound, to preparations comprising these compounds, and to specific dicyclohexylmethanol derivatives and to a process for the preparation thereof.. . ... Merck Patent Gmbh

04/30/15 / #20150118165

Use of cyclohexanol ethers having antimicrobial properties

The present invention relates to the use of at least one cyclohexanol ether derivative of the formula i as antimicrobial active compound or as anti-acne, antidandruff, deodorant or antiperspirant active compound, to preparations comprising these compounds, and to specific cyclohexanol ether derivatives.. . ... Merck Patent Gmbh

04/30/15 / #20150115239

Electronic devices

The application relates to an electronic device comprising anode, cathode, at least one emitting layer between anode and cathode, at least one p-doped layer a which comprises a monotriarylamine as host, and at least one layer b comprising a monotriarylamine. The invention furthermore relates to a p-doped mixture comprising a monotriarylamine of the formula (ii), (iii) or (iv) as host and an electron-acceptor compound as dopant and to the use of the mixture in an electronic device.. ... Merck Patent Gmbh

04/23/15 / #20150111933

Deuterated thiazolidinone analogues as agonists for follicle stimulating hormone receptor

The present invention relates to deuterated thiazolidinone analogues as agonists for follicle stimulating hormone receptor and their use for treating fertility disorders.. . ... Merck Patent Gmbh

04/23/15 / #20150110999

Process for producing three-dimensional patterns in liquid-crystalline coatings

The present invention relates to a method for producing three-dimensional macroscopic patterns in liquid-crystalline coatings, patterned layers containing liquid-crystalline materials and produced by said method, and the use thereof in decorative and security products. In the method, the liquid-crystalline coating in a non-solidified state is brought into contact with a printing form for a relief printing method, with the result that depressions which are not deeper than 10 μm arise in the coating.. ... Merck Patent Gmbh

04/23/15 / #20150108409

Small molecules and their use as organic semiconductors

The invention relates to compounds based on benzo[1,2-b:4,5-b′]dithiophene (bdt), methods for their preparation and intermediates used therein, mixtures and formulations containing them, the use of the compounds, mixtures and formulations as semiconductor in organic electronic (oe) devices, especially in organic photovoltaic (opv) devices, and to oe devices comprising these compounds, mixtures or formulations.. . ... Merck Patent Gmbh

04/23/15 / #20150108408

Cross-linkable and cross-linked polymers, process for the preparation thereof, and the use thereof

The present invention relates to cross-linkable and cross-linked polymers, methods for the production thereof, the use of said cross-linked polymers in electronic devices, especially in oleds (oled=organic light emitting diode), and to electronic devices, especially organic electroluminescent devices which contain the cross-linked polymers.. . ... Merck Patent Gmbh

04/16/15 / #20150105843

Metal complexes comprising condensed heteroaromatic rings

The present invention relates inter alia to a new class of heteroleptic metal complexes comprising condensed aromatic heterocyclic rings, their preparation and use.. . ... Merck Patent Gmbh

04/16/15 / #20150105560

Formulation comprising ionic organic compounds for use in electron transport layers

The invention relates to formulations comprising ionic organic compounds for use in electron transport layers or electron collecting layers of organic electronic (oe) devices, more specifically in organic photovoltaic (opv) devices, to electron transport layers comprising or being made through the use of such formulations, and to oe and opv devices comprising such formulations or electron transport layers.. . ... Merck Patent Gmbh

04/16/15 / #20150104865

Engineered heterodimeric protein domains

The present invention provides an engineered multidomain protein including at least two nonidentical engineered domains, each of which contains a protein-protein interaction interface containing amino acid sequence segments derived from two or more existing homologous parent domains, thereby conferring on the engineered domains assembly specificities distinct from assembly specificities of the parent domains. In particular, the engineered domains form heterodimers with one another preferentially over forming homodimers. ... Merck Patent Gmbh

04/16/15 / #20150104512

Coated tablets and the production thereof

The present invention provides a rapidly disintegrating pharmaceutical formulation in the form of a coated tablet having increased mechanical strength, or hardness. The invention furthermore relates to a process for the production of the coated tablet and to the use of these formulations.. ... Merck Patent Gmbh

04/09/15 / #20150099119

Particles for electrophoretic displays

This invention relates to coloured polymer, a process for their preparation, electrophoretic fluids comprising such particles, and electrophoretic display devices comprising such fluids.. . ... Merck Patent Gmbh

04/09/15 / #20150098914

Glucuronolactone derivatives as self-tanning substances

The invention relates to the use of specific glucuronolactone derivatives as self-tanning substances, as tanning enhancers for dihydroxyacetone or for a mixture of self-tanning substances comprising dihydroxyacetone, for modulation of the colour shade achieved in the case of tanning with dihydroxyacetone or by the mixture or preparation comprising dihydroxyacetone, as contrast-reduction agents or for colouring keratin-containing fibres, and to preparations or compositions for colouring keratin-containing fibres comprising these specific glucuronolactone derivatives.. . ... Merck Patent Gmbh

04/02/15 / #20150092262

Particles for electrophoretic displays comprising a core and a random-copolymer coating

. . This invention relates to particles comprising a core particle and a polymeric shell, electrophoretic fluids comprising such particles, and electrophoretic display devices comprising such fluids.. . ... Merck Patent Gmbh

03/26/15 / #20150087594

Induced neural stem cells

The present invention relates to a method of deriving an induced neural stem cell (incs) by nuclear reprogramming of a somatic cell, wherein the method comprises a step of contacting the somatic cell with oct4 protein or a functionally equivalent analogue, variant or fragment thereof for a limited time period, as well as an induced neural stem cell obtained by this method.. . ... Merck Patent Gmbh

03/26/15 / #20150085472

Silicate phosphors

The present invention relates to eu-, sm- or pr-doped silicate compounds, to a process for the preparation thereof and to the use thereof as conversion phosphors. The present invention also relates to an emission-converting material comprising at least the conversion phosphor according to the invention and to the use thereof in light sources, in particular pc-leds (phosphor converted light emitting devices). ... Merck Patent Gmbh

03/19/15 / #20150080411

Polymorphic forms of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl) piperazine hydrochloride

The invention relates to new crystalline modifications of the hydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine, crystalline modification of the dihydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine and amorphous 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride which are suitable in particular for the preparation of solid medicaments for the treatment or prevention of depressive disorders, anxiety disorders, bipolar disorders, mania, dementia, substance-related disorders, sexual dysfunctions, eating disorders, obesity, fibromyalgia, sleeping disorders, psychiatric disorders, cerebral infarct, tension, for the therapy of side-effects in the treatment of hypertension, cerebral disorders, chronic pain, acromegaly, hypogonadism, secondary amenorrhea, premenstrual syndrome and undesired puerperal lactation.. . ... Merck Patent Gmbh

03/19/15 / #20150079120

Dna sequence and preparation of grass pollen allergen phl p4 by recombinant methods

The present invention relates to the preparation and use of recombinant variants of group 6 allergens of the poaceae (true grasses), which are characterised by reduced ige reactivity compared with known wild-type allergens and at the same time substantially retained reactivity with t-lymphocytes.. . ... Merck Patent Gmbh

03/19/15 / #20150076418

Conjugated polymers

The invention relates to novel conjugated polymers comprising in their backbone one or more divalent donor units, like for example benzo[1,2-b:4,5-b′]dithiophene-2,6-diyl (bdt), that are linked on both sides to an acceptor unit, to methods of preparing the polymers and educts or intermediates used in such preparation, to polymer blends, mixtures and formulations containing the polymers, to the use of the polymers, polymer blends, mixtures and formulations as semiconductors organic electronic (oe) devices, especially in organic photovoltaic (opv) devices and organic photodetectors (opd), and to oe, opv and opd devices comprising these polymers, polymer blends, mixtures or formulations.. . ... Merck Patent Gmbh

03/19/15 / #20150076415

Polymers containing substituted oligo-triarylamine units and electroluminescence devices containing such polymers

The present invention relates to polymers containing oligo-triarylamine repetition units that are substituted in the ortho position, a method for the production thereof, and use thereof in electronic devices, particularly in organic electroluminescence devices, known as oleds (oled=organic light emitting diodes). The present invention further relates to organic electroluminescence devices containing these polymers.. ... Merck Patent Gmbh

03/12/15 / #20150071953

Variants of group 6 allergens of the true grasses having reduced allergeneity due to mutagenesis of proline residues

The present invention relates to the preparation and use of recombinant variants of group 6 allergens of the poaceae (true grasses), which are characterised by reduced ige reactivity compared with known wild-type allergens and at the same time substantially retained reactivity with t-lymphocytes.. . ... Merck Patent Gmbh

03/12/15 / #20150070628

Electro-optical switching element and electro-optical display

The present invention relates to electro-optical switching elements and displays comprising them. In particular, it relates to electro-optical switching elements comprising at least a light reflecting layer, a light switching layer, and a light conversion layer, which comprises one or more light emitting substances, in particular, a light reflecting layer, which selectively reflects visible light, a light controlling element that controls the amount of transmitted and/or reflected light, and a light converting layer that shifts the wavelength of the transmitted light to longer values. ... Merck Patent Gmbh

03/12/15 / #20150070609

Liquid crystal medium

The present invention relates to a liquid crystal (lc) medium comprising a polymerizable compound, to a process for its preparation, to its use for optical, electro-optical and electronic purposes, in particular in an lc display, especially in an lc display of the psa (“polymer sustained alignment”) type, and to an lc display comprising the lc medium.. . ... Merck Patent Gmbh

03/12/15 / #20150069304

Cyclohexadiene fullerene derivatives

The invention relates to novel fullerene derivatives, to methods for their preparation and educts or intermediates used therein, to mixtures and formulations containing them, to the use of the fullerene derivatives, mixtures and formulations as organic semiconductors in, or for the preparation of, organic electronic (oe) devices, especially organic photovoltaic (opv) devices and organic photodetectors (opd), and to oe, opv and opd devices comprising, or being prepared from, these fullerene derivatives, mixtures or formulations.. . ... Merck Patent Gmbh

03/12/15 / #20150069303

Polymers containing substituted triarylamine units and electroluminescent devices containing said polymers

The present invention relates to polymers which contain triarylamine repeating units that are substituted in the ortho position, methods for the production thereof, and the use thereof in electronic devices, especially in organic electroluminescent devices, so-called oleds (oled=organic light emitting diode). The present invention also relates to organic electroluminescent devices which contain said polymers.. ... Merck Patent Gmbh

03/12/15 / #20150069287

Thermally conductive, plate-shaped pigment coated with aluminium oxide

The present invention relates to thermally conductive pigments which consist of a substrate and a coating applied thereto comprising aluminium oxide and/or aluminium oxide hydrate, to a process for the preparation of these pigments, and to the use thereof.. . ... Merck Patent Gmbh

03/12/15 / #20150068979

Holder for monolithic sorbents

The present invention relates to a holder for monolithic sorbents in which a radial pressure can be exerted over the entire length of the sorbent by a conically tapering clamping tube.. . ... Merck Patent Gmbh

03/05/15 / #20150065730

Spirobifluorene compounds for organic electroluminescent devices

. . The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which comprise these compounds.. . ... Merck Patent Gmbh

03/05/15 / #20150065691

Anti-cancer antibodies with reduced complement fixation

The invention provides modified antibodies directed against gd2 that have diminished complement fixation relative to antibody-dependent, cell-mediated cytotoxicity, which is maintained. The modified antibodies of the invention may be used in the treatment of tumors such as neuroblastoma, glioblastoma, melanoma, small-cell lung carcinoma, b-cell lymphoma, renal carcinoma, retinoblastoma, and other cancers of neuroectodermal origin.. ... Merck Patent Gmbh

03/05/15 / #20150065644

Particles for electrowetting displays

This invention relates to polymer particles for use in electrowetting fluids and electrowetting displays devices comprising such particles.. . ... Merck Patent Gmbh

02/26/15 / #20150057445

Substituted tetraarylbenzenes

. . The present invention relates to substances, to electroluminescent device comprising these substances, and to the use thereof.. . ... Merck Patent Gmbh

02/26/15 / #20150056229

Dna sequence, and recombinant preparation of the grass pollen allergen lol p 4

The present invention relates to the provision of a dna sequence of the major grass pollen allergen lol p 4. The invention also encompasses fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. ... Merck Patent Gmbh

02/19/15 / #20150051409

Process for preparing benzo[1,2-b;4,5-b']dithiophene-4,8-dicarboxylic acid or its 2,3-dihydro derivative

. . . . The invention relates to a process for preparing benzo[1,2-b;4,5-b′]dithiophene-4,8-dicarboxylic acid or its 2,3-dihydro derivative, and to novel products prepared by this process.. . ... Merck Patent Gmbh

02/19/15 / #20150051295

Use of propanol and propenol derivatives as antioxidants

The invention relates to the use of propanol and propenol derivatives as antioxidants, to compositions comprising propanol and propenol derivatives and the preparation thereof, and to certain propanol and propenol derivatives and the preparation thereof.. . ... Merck Patent Gmbh

02/19/15 / #20150051181

Process for producing nanoparticles laden with active ingredient

The present invention relates to a novel process for the production of nanoparticles laden with active compounds and to the use thereof as medicaments. The process for the production of nanoparticles comprises the steps (a) dissolution of at least one active compound and at least one polymer in an organic solvent, (b) mixing of the solution prepared in step (a) with an aqueous phase, (c) evaporation of the organic solvent, (d) purification of the nanoparticles laden with active compound obtained in step (c) by means of dialysis against aqueous dialysis solution comprising the same active compound.. ... Merck Patent Gmbh

02/19/15 / #20150048279

Conjugated polymers

The invention relates to novel conjugated polymers containing one or more repearting units derived from indacenodibenzothiophene or dithia-dicyclopenta-dibenzothiophene, to methods for their preparation and educts or intermediates used therein, to polymer blends, mixtures and formulations containing them, to the use of the polymers, polymer blends, mixtures and formulations as organic semiconductors in organic electronic (oe) devices, especially in organic photovoltaic (opv) devices, and to oe and opv devices comprising these polymers, polymer blends, mixtures or formulations.. . ... Merck Patent Gmbh

02/12/15 / #20150045572

Process for the preparation of phosphinic acid esters

The invention relates to a process for the preparation of alkyl phosphinates, alkenyl phosphinates, alkynyl phosphinates or phenyl phosphinates by reaction of a corresponding phosphine oxide with an alcohol or phenol in the presence of alkali-metal fluoride or tetraalkylammonium fluoride.. . ... Merck Patent Gmbh

02/12/15 / #20150045529

9,9'-spirobixanthene derivatives for electroluminescent devices

The present invention relates to compounds suitable for use in electronic devices, and to electronic devices, especially organic electroluminescent devices, comprising these compounds.. . ... Merck Patent Gmbh

02/12/15 / #20150044211

Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with other anti-tumor compounds

A pharmaceutical composition of 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile or a pharmaceutically acceptable salt and/or solvate thereof in combination with a compound selected from the group erlotinib, cetuximab, aflibercept, bevacizumab.. . ... Merck Patent Gmbh

02/12/15 / #20150041727

Organic semiconducting polymers

The invention relates to novel organic semiconducting polymers containing one or more monomers derived from s-indacene fused symmetrically on each terminus with dithieno[3,2-b;2′,3′-d]thiophene (iddtt), cyclopenta[2,1-b;3,4-b′]dithiophene (idcdt), or derivatives thereof, to methods for their preparation and educts or intermediates used therein, to polymer blends, mixtures and formulations containing them, to the use of the polymers, polymer blends, mixtures and formulations as semiconductors in organic electronic (oe) devices, especially in organic photovoltaic (opv) devices and organic photodetectors (opd), and to oe, opv and opd devices comprising these polymers, polymer blends, mixtures or formulations.. . ... Merck Patent Gmbh

02/12/15 / #20150041712

Composite ceramic which comprises a conversion phosphor and a material having a negative coefficient of thermal expansion

The present invention relates to a composite ceramic which comprises a conversion phosphor and a further material, characterised in that the further material has a negative coefficient of thermal expansion, and to a process for the preparation thereof. Furthermore, the present invention also relates to the use of the composite ceramic according to the invention as emission-converting material, preferably in a white light source, and to a light source, a lighting unit and a display device.. ... Merck Patent Gmbh

02/05/15 / #20150037203

Nanocrystals on fibers

. . . . The present invention relates inter alia to light- and/or irradiation-emitting fibers comprising nanocrystals, in particular quantum dots and nanorods, their preparation and use. The fiber may have a fiber core 10, an outer first electrode 20, a light emitting layer 30, a radiation transmissive second electrode 40 positioned over the organic light emitting layer 30. ... Merck Patent Gmbh

01/29/15 / #20150031896

Compounds for organic electronic devices

The present invention relates to the improvement of organic electroluminescent devices, in particular blue-emitting devices, by using compounds of the formula (1) as dopants in the emitting layer.. . ... Merck Patent Gmbh

01/29/15 / #20150031882

Methods for treating cancer using pi3k inhibitor and mek inhibitor

Methods of treating patients with cancer are provided, wherein the methods comprise administering to the patient an effective amount of a mek inhibitor and an effective amount of a pi3k inhibitor. Compositions in which the mek and pi3k inhibitors are combined also are described.. ... Merck Patent Gmbh

01/29/15 / #20150031670

Cyclic amides as metap-2 inhibitors

Compounds of the formula (i), in which r1, r3, r5, r6, r7, r, x and y have the meanings indicated in claim 1, are inhibitors of methionine aminopeptidase and can be employed for the treatment of tumours.. . ... Merck Patent Gmbh

01/29/15 / #20150030670

Aminoacid lipids

The present invention is directed to a new class of lipids, more specifically ether-lipids having a polar headgroup, as well as vesicles comprising these lipids, methods of their preparation as well as their uses in medical applications, wherein the ether-lipids are represented by general formula i. . ... Merck Patent Gmbh

01/29/15 / #20150030669

Targeting aminoacid lipids

The present invention is directed to carrier systems comprising ether-lipids conjugated to one or more bioactive ligands and exposed on the surface of the carrier system for use in targeted delivery and/or antigen display systems. Optionally one or more further bioactive agents may be encapsulated or embedded within or attached to or adsorbed onto the carrier system. ... Merck Patent Gmbh

01/22/15 / #20150023899

Pigment mixture

. . The present invention relates to a pigment mixture based on spherical particles having a defined particle-size distribution, and to the use thereof in paints, coatings, printing inks, security printing inks, plastics, ceramic materials, glasses, in cosmetic formulations, as tracer, as filler and for the preparation of pigment preparations and dry preparations.. . ... Merck Patent Gmbh

01/15/15 / #20150018526

Cytotoxins comprising modified bouganin toxin for the treatment of cancer

. . The invention provides modified forms of bouganin protein having biological activity and a reduced propensity to activate human t cells as compared to the non-modified bouganin protein. The invention also provides t-cell epitope peptides of bouganin, and modified t-cell epitope peptides of bouganin which have a reduced propensity to activate human t cells as compared to the non-modified t-cell epitope peptide. ... Merck Patent Gmbh

01/15/15 / #20150018343

Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators

The present invention provides compounds of formula (i) as m1 receptor positive allosteric modulators for the treatment of diseases mediated by the muscarinic m1 mediator.. . ... Merck Patent Gmbh

01/15/15 / #20150015931

Electrowetting fluids

This invention relates to electrowetting fluids, the use of these fluids for the preparation of an electrowetting displays devices, and electrowetting display devices comprising such fluids.. . ... Merck Patent Gmbh

01/15/15 / #20150014598

Polymers containing dibenzocycloheptene structural units

The invention relates to polymers containing dibenzocycloheptene structural units, to a method for the production thereof, and to blends and formulations containing said polymers. The invention further relates to the use of the polymers or blends according to the invention in electronic devices and to electronic devices, in particular oleds, containing the polymers or blends according to the invention.. ... Merck Patent Gmbh

01/15/15 / #20150014584

Liquid crystal medium and high frequency components comprising same

The present invention relates to liquid crystal media and to high frequency components comprising same, especially microwave components for high-frequency devices, such as devices for shifting the phase of microwaves.. . ... Merck Patent Gmbh

01/08/15 / #20150011557

Benzyl piperidine compounds as lysophosphatidic acid (lpa) receptor antagonist

. . The invention provides novel substituted benzyl piperidine compounds according to formula (i) as lysophosphatidic acid (lpa) receptor antagonists, their manufacture and use for the treatment of proliferative or inflammatory diseases, such as cancer, fibrosis or arthritis.. . ... Merck Patent Gmbh

01/08/15 / #20150011534

Pyridazinone derivatives

Compounds of the formula (i), in which r1, r2, r3, r4, r4′ have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular met kinase, and can be employed, inter alia, for the treatment of tumours.. . ... Merck Patent Gmbh

01/08/15 / #20150008373

Reactive mesogen formulation with conductive additive

The invention relates to a reactive mesogen (rm) formulation comprising a conductive additive, to a polymer film obtained thereof, and the use of the rm formulation and polymer film in optical or electrooptical components or devices, like optical retardation films for liquid crystal displays (lcds).. . ... Merck Patent Gmbh

01/01/15 / #20150005294

Azaheterocyclic compounds

. . The invention provides novel substituted azaheterocyclic compounds compounds according to formula (i), their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.. . ... Merck Patent Gmbh








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