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Micromass Uk Limited patents


Recent patent applications related to Micromass Uk Limited. Micromass Uk Limited is listed as an Agent/Assignee. Note: Micromass Uk Limited may have other listings under different names/spellings. We're not affiliated with Micromass Uk Limited, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "M" | Micromass Uk Limited-related inventors


 new patent  Ambient ionisation with an impactor spray source

An ion source is disclosed comprising a nebuliser 1 arranged and adapted to emit a liquid spray, a first target 5 arranged downstream of the nebuliser 1, wherein the liquid spray is arranged to impact upon the first target 5, and a sample target 10 arranged downstream of the first target 5, wherein a sample to be analysed is provided at the sample target 10.. . ... Micromass Uk Limited

Mass filter having extended operational lifetime

A mass filter is disclosed having at least one electrode (42-48) comprising an aperture (43) or recess. Voltages are applied to the electrodes (42-48) of the mass filter such that ions having mass to charge ratios in a desired range are confined by the electrodes and are transmitted along and through the mass filter, whereas ions (47,49) having mass to charge ratios outside of said desired range are unstable and pass into the aperture (43) or recess such that they are filtered out by the mass filter. ... Micromass Uk Limited

A method of mass analysis using ion filtering

A method of mass spectrometry is disclosed comprising detecting the ions transmitted by a mass filter (4) with a detector (6); changing the rf and/or dc voltage applied to the mass filter (4) during a voltage transition period so as to change the mass to charge ratio capable of being transmitted by the mass filter (4); preventing ions from reaching the detector during the voltage transition period; and allowing ions to be transmitted to the detector (6) after the voltage transition period.. . ... Micromass Uk Limited

Echo cancellation for time of flight analogue to digital converter

A method of mass spectrometry is disclosed comprising digitising a signal output from a detector to provide a first digitised signal. A finite impulse response (“fir”) filter, a digital filter or an echo cancellation filter is applied to the first digitised signal in order to reduce the effect of baseline perturbations, echoes or ringing effects. ... Micromass Uk Limited

Separating ions in an ion trap

A method is disclosed comprising: trapping ions in an ion trap (40); applying a first force on the ions within the ion trap in a first direction, said force having a magnitude that is dependent upon the value of a physicochemical property of the ions; applying a second force on these ions in the opposite direction so that the ions separate according to the physicochemical property value as a result of the first and second forces; and then pulsing or driving ions out of one or more regions of the ion trap.. . ... Micromass Uk Limited

Sample mass spectrum analysis

A method of analysing a sample mass spectrum comprises comparing a sample mass spectrum of a sample with each reference mass spectrum of plural reference mass spectra. A similarity index is assigned to each reference mass spectrum of the plural reference mass spectra based on similarity between the sample mass spectrum and the reference mass spectrum. ... Micromass Uk Limited

Oversampled time of flight mass spectrometry

A method of mass spectrometry is disclosed comprising passing ions to an oversampled time of flight mass analyser (4) and sequentially recording ion signals on a plurality of different channels (51, 52) to obtain a plurality of first oversampled mass spectral data sets of reduced complexity. An upstream separation device (3) may be provided to further reduce the complexity of each of the mass spectral data sets.. ... Micromass Uk Limited

Compact mass spectrometer

A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. ... Micromass Uk Limited

Lock mass library for internal correction

A method of calibrating or optimising an analytical instrument is disclosed that comprises analysing analyte from a sample using an analytical instrument, determining a sample type of the sample based on analysis of analyte from the sample, identifying one or more species of the analyte that are known to be endogenous to the determined sample type, and calibrating or optimising the analytical instrument using the one or more identified endogenous species.. . ... Micromass Uk Limited

Adaptive and targeted control of ion populations to improve the effective dynamic range of mass analyser

A method of mass spectrometry is disclosed wherein one or more relatively abundant or intense species of ions in a first population of ions are selectively attenuated so as to form a second population of ions. The total ion current of the second population of ions is then adjusted so that the ion current corresponding to ions which are onwardly transmitted to a mass analyser comprising an ion detector is within the dynamic range of the ion detector.. ... Micromass Uk Limited

Tissue analysis by mass spectrometry or ion mobility spectrometry

A method of analysis using mass and/or ion mobility spectrometry or ion mobility spectrometry is disclosed comprising: using a first device to generate aerosol, smoke or vapour from one or more regions of a first target of biological material; and mass and/or ion mobility analysing and/or ion mobility analysing said aerosol, smoke, or vapour, or ions derived therefrom so as to obtain first spectrometric data. The method may use an ambient ionisation method.. ... Micromass Uk Limited

Automated beam check

A method of automatically performing a routine to check the operational state of a mass spectrometer is disclosed wherein the method is performed automatically as a start-up routine upon switching on the mass spectrometer. The method comprises automatically generating a vacuum within one or more vacuum chambers of a mass spectrometer and automatically generating first ions using an internal ion source, wherein the internal ion source is located within a vacuum chamber of the mass spectrometer or is located within a chamber downstream from an atmospheric pressure interface, and detecting at least some of the first ions or second ions derived from the first ions. ... Micromass Uk Limited

Cell population analysis

A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed comprising: (a) using a first device to generate smoke, aerosol or vapour from a target in vitro or ex vivo cell population; (b) mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and (c) analysing said spectrometric data in order to identify and/or characterise said target cell population or one or more cells and/or compounds present in said target cell population.. . ... Micromass Uk Limited

Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry ("reims") device

An apparatus is disclosed comprising a first device for generating aerosol, smoke or vapour from one or more regions of a target, an inlet conduit to an ion analyser or mass spectrometer, the inlet conduit having an inlet through which the aerosol, smoke or vapour passes, and a venturi pump arrangement arranged and adapted to direct the aerosol, smoke or vapour towards the inlet.. . ... Micromass Uk Limited

03/01/18 / #20180057852

Spectrometric analysis of microbes

A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed. The method comprises: using a first device to generate smoke, aerosol or vapour from a target comprising or consisting of a microbial population; mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and analysing said spectrometric data in order to analyse said microbial population.. ... Micromass Uk Limited

02/22/18 / #20180053644

Improved ionisation of gaseous samples

A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing an analyte; supplying a matrix compound to said analyte such that said analyte dissolves in said matrix; forming first droplets of the dissolved analyte; and colliding said first droplets with a collision surface. The use of matrix improves the analyte ion signal.. ... Micromass Uk Limited

02/22/18 / #20180049643

In vivo endoscopic tissue identification tool

An apparatus is disclosed including a tool comprising a first device for generating aerosol from a target, the first device being deployed through an opening in a tubing of the tool, wherein the tubing is provided with aspiration ports or fenestrations such that the generated aerosol is aspirated into the tubing via the aspiration ports or fenestrations. The aspirated aerosol is then transferred to a mass spectrometer for subsequent mass analysis.. ... Micromass Uk Limited

02/15/18 / #20180047556

Orthogonal acceleration coaxial cylinder time of flight mass analyser

A time of flight mass analyser is disclosed comprising an annular ion guide having a longitudinal axis and comprising a first annular ion guide section and a second annular ion guide section. Ions are introduced into the first annular ion guide section so that the ions form substantially stable circular orbits within the first annular ion guide section about the longitudinal axis. ... Micromass Uk Limited

02/15/18 / #20180047555

Imaging guided ambient ionisation mass spectrometry

A method is disclosed comprising obtaining or acquiring image or other data from one or more regions of a target using an imaging sensor. The image or other data may then be used to determine one or more regions of interest of the target. ... Micromass Uk Limited

02/15/18 / #20180047554

Rapid evaporative ionisation mass spectrometry ("reims") and desorption electrospray ionisation mass spectrometry ("desi-ms") analysis of swabs and biopsy samples

A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.. . ... Micromass Uk Limited

02/15/18 / #20180047553

Spectrometric analysis

A method of spectrometric analysis comprises obtaining one or more sample spectra for an aerosol, smoke or vapour sample. The one or more sample spectra are subjected to pre-processing and then multivariate and/or library based analysis so as to classify the aerosol, smoke or vapour sample. ... Micromass Uk Limited

02/15/18 / #20180047551

Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue

A method of ion imaging is disclosed that includes automatically sampling a plurality of different locations on a sample using a front device which is arranged and adapted to generate aerosol, smoke or vapour from the sample. Mass spectral data and/or ion mobility data corresponding to each location is obtained and the obtained mass spectral data and/or ion mobility data is used to construct, train or improved a sample classification model.. ... Micromass Uk Limited

02/15/18 / #20180045679

Method of screening samples

A method of screening a sample for at least one compound of interest is disclosed. The method comprises comparing the ion mobility and at least one further physicochemical property of the ions of a compound of interest to the same properties of candidate ions in the sample. ... Micromass Uk Limited

02/15/18 / #20180042583

Chemically guided ambient ionisation mass spectrometry

A method is disclosed comprising obtaining or acquiring chemical or other non-mass spectrometric data from one or more regions of a target using a chemical sensor. The chemical or other non-mass spectrometric data may be used to determine one or more regions of interest of the target. ... Micromass Uk Limited

02/15/18 / #20180042582

Physically guided rapid evaporative ionisation mass spectrometry ("reims")

A method is disclosed comprising obtaining physical or other non-mass spectrometric data from one or more regions of a target using a probe. The physical or other non-mass spectrometric data may be used to determine one or more regions of interest of the target. ... Micromass Uk Limited

02/08/18 / #20180038838

Collision surface for improved ionisation

An apparatus for performing ambient ionisation mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil-shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapour onto said collision assembly.. ... Micromass Uk Limited

01/11/18 / #20180012743

Method of charge reduction of electron transfer dissociation product ions

A mass spectrometer is disclosed wherein highly charged fragment ions resulting from electron transfer dissociation fragmentation of parent ions are reduced in charge state within a proton transfer reaction cell by reacting the fragment ions with a neutral superbase reagent gas such as octahydropyrimidolazepine.. . ... Micromass Uk Limited

01/11/18 / #20180011055

Method of charge state selection

A method of mass spectrometry or ion mobility spectrometry is disclosed in which analyte ions of a desired charge state are isolated. The method comprises: separating analytes according to their electrophoretic mobility; ionising the analytes; and mass filtering the resulting analyte ions, wherein the mass to charge ratios of the ions transmitted by a mass filter are varied as a function of the electrophoretic mobility and according to a predetermined relationship such that substantially only ions having said desired charge state are transmitted by the mass filter.. ... Micromass Uk Limited

12/28/17 / #20170372881

Mass spectrometer

A mass spectrometer is disclosed comprising a mass selective ion trap and a quadrupole rod set mass filter arranged downstream of the mass selective ion trap. Ions are mass selectively ejected from the ion trap in a substantially synchronised manner with the scanning of the mass filter in order to increase the duty cycle of the mass filter.. ... Micromass Uk Limited

12/21/17 / #20170365452

Method of calibrating ion signals

A method of mass or ion mobility spectrometry is disclosed comprising: providing an ion source for generating analyte ions and reference ions; providing a mass analyser or ion mobility separator (ims); providing an ion trap between the ion source and the mass analyser or ims; guiding reference ions from the ion source into the ion trap and trapping the reference ions in the ion trap; guiding the analyte ions from the ion source into the mass analyser or ims, wherein the analyte ions bypass the ion trap; and releasing reference ions from the ion trap into the mass analyser or ims for analysis.. . ... Micromass Uk Limited

12/14/17 / #20170358433

Mass spectrometer with bypass of a fragmentation device

A method for analyzing a mixture of components includes forming precursor ions from the components, alternately causing the precursor ions to pass to and to by-pass a fragmentation device, to form product ions from the precursor ions that pass to the device and to form substantially fewer product ions from precursor ions that by-pass the device, and obtaining mass spectra from product ions received from the device and from precursor ions that by-passed the device. An apparatus for analyzing a sample includes an ion source for forming precursor ions from the components of the sample, a fragmentation device for forming product ions from the precursor ions, a by-pass device disposed upstream of the fragmentation device for switchable by-pass of the fragmentation device, and a mass analyzer.. ... Micromass Uk Limited

11/30/17 / #20170345637

Efficient ion trapping

An ion trapping system is disclosed comprising an ion urging system for urging ions to spread out within an ion trapping region. Alternatively, the ion trapping system may deflect ions such that ions enter the ion trapping region at different locations. ... Micromass Uk Limited

11/23/17 / #20170338093

Method of separating ions

The present disclosure relates generally to a method of separating ions according to their ion mobility, comprising (i) accumulating a first population of ions in a first region of an ion mobility separator, (ii) separating said first population of ions according to their ion mobility in said first region of said ion mobility separator, and (iii) accumulating a second population of ions in said first region of said ion mobility separator whilst said first population of ions are being separated according to their ion mobility in said ion mobility separator.. . ... Micromass Uk Limited

10/12/17 / #20170294296

Probe adaptor assembly

An apparatus for connecting an ionisation probe assembly to a mass and/or ion mobility spectrometer is disclosed. The apparatus comprises: an attachment member for releasably attaching a probe assembly to the apparatus; a cap for enclosing the attachment member; wherein the apparatus is operable to deliver a voltage to a probe assembly only when the cap is arranged to enclose the attachment member; and wherein the cap is configurable to enclose the attachment member when a probe assembly is attached to the apparatus.. ... Micromass Uk Limited

10/12/17 / #20170292960

Mass spectrometry for determining if a mutated variant of a target protein is present in a sample

A method of mass spectrometry is disclosed for determining if a mutated variant of a target protein is present in a sample. The method comprises subjecting the sample to fragmentation so as to cause said target protein to fragment to form second generation fragment ions, and then mass analysing these fragment ions to obtain spectral data. ... Micromass Uk Limited

10/12/17 / #20170292641

Probe assembly connector

An attachment device for releasably attaching a fluid line to a fluid inlet or outlet is disclosed. The device comprises an attachment member for releasably engaging a fluid inlet or outlet, and an elastic member coupled to the attachment member. ... Micromass Uk Limited

10/05/17 / #20170287692

Combined mass-to-charge ratio and charge state selection in tandem mass spectrometry

A mass spectrometer is disclosed comprising an ion mobility spectrometer and an ion gate. A collision cell is arranged downstream of the ion gate. ... Micromass Uk Limited

10/05/17 / #20170284983

Interface probe

A gc fitting for an inner tube of a heated transfer line of a gas chromatography interface probe, the fitting comprising a first section comprising a substantially cylindrical projection for fluid connection to a gc source in use, and a second section having a larger radius than the first section in at least one direction, the second section being provided with at least one flat.. . ... Micromass Uk Limited

09/28/17 / #20170276645

Accurate mobility chromatograms

A method of mass spectrometry is disclosed comprising: a) separating first ions or components of an analyte sample according to a physicochemical property other than ion mobility; b) separating said first ions or second ions formed from said components according to ion mobility; c) detecting the intensities of said first ions, or detecting the intensities of second ions formed from said components, or detecting the intensities of ions derived from said first or second ions; wherein the intensity of the ions detected at any given time is recorded together with an associated value of said physicochemical property and an associated value of said ion mobility so as to obtain spectral data; d) examining the intensities of the spectral data as a function of said ion mobility so as to detect an intensity peak in said spectral data, determining a discrete value of ion mobility for said peak, and defining a window of values of ion mobility that encompasses said discrete value; and e) filtering said spectral data so as to include only spectral data that has been associated with values of ion mobility that are within said window of ion mobility values.. . ... Micromass Uk Limited

09/21/17 / #20170271141

Fast modulation with downstream homogenisation

A method of mass spectrometry is disclosed involving scanning a parameter of a first device through which a mixture of components is passed. Different components are transmitted through or produced in the first device at different values of the parameter and hence scanning the device parameter introduces a temporal modulation or profile to the components. ... Micromass Uk Limited

09/14/17 / #20170263430

Low cross-talk fast sample delivery system based upon acoustic droplet ejection

An ion source for a mass spectrometer is disclosed comprising an ultrasonic transducer which focuses ultrasonic energy onto a surface of a sample fluid without directly contacting the sample fluid.. . ... Micromass Uk Limited

09/14/17 / #20170263428

Impactor spray ion source

There is provided an ion source comprising one or more nebulisers and one or more targets, wherein said one or more nebulisers are arranged and adapted to emit, in use, a stream predominantly of droplets which are caused to impact upon said one or more targets and to ionise said droplets to form a plurality of ions, wherein said one or more targets further comprise one or more structures configured to disturb gas flowing along a surface of said one or more targets.. . ... Micromass Uk Limited

09/14/17 / #20170263425

Multi-dimensional survey scans for improved data dependent acquisitions

A method of analysing ions is disclosed comprising performing an initial multi-dimensional survey scan comprising separating parent ions according to a first physico-chemical property (e.g. Ion mobility) and then separating the parent ions according to a second physico-chemical property (e.g. ... Micromass Uk Limited

09/14/17 / #20170263424

Two-dimensional separation and imaging technique for the rapid analysis of biological samples

A method of ion mapping is disclosed comprising depositing a sample onto a target surface and separating the sample on the target surface according to a first physico-chemical property in a first dimension and according to a second physico-chemical property in a second dimension. The method further comprises ionising and mass analysing multiple separate regions of the sample so as to generate an ion map of at least a portion of the sample deposited upon the target surface. ... Micromass Uk Limited

09/07/17 / #20170254776

Theoretical collision cross section ("ccs") in experimental design

A method of mass spectrometry is disclosed comprising calculating an ion mobility value, collision cross section or interaction cross section of a plurality of different analyte ions under one or more different analytical conditions, and setting one or more operational parameters of a mass spectrometer in response to the calculated ion mobility values, collision cross sections or the calculated interaction cross sections so as to maximise or enhance a subsequent ion mobility separation of a plurality of different analyte ions.. . ... Micromass Uk Limited

08/31/17 / #20170250062

Unknown identification using collision cross section

A method of mass spectrometry is disclosed comprising experimentally determining or measuring one or more first ion mobility values, collision cross sections or interaction cross sections collision cross sections or first ion mobility parameters and one or more mass or mass to charge ratios of one or more analyte ions, generating a first list of possible candidate compounds which correspond to said one or more analyte ions on the basis of the one or more determined or measured masses or mass to charge ratios, and calculating, estimating or determining one or more second ion mobility values, collision cross sections or interaction cross sections collision cross sections or second ion mobility parameters of at least some of the candidate compounds in the first list. The method further comprises a step of either: (i) generating a second reduced list of possible candidate compounds by filtering or removing candidate compounds from the first list if the difference between said one or more experimentally determined or measured first ion mobility values, collision cross sections or interaction cross sections collision cross sections or first ion mobility parameters and the one or more calculated, estimated or determined second ion mobility values, collision cross sections or interaction cross sections collision cross sections or second ion mobility parameters is greater than a predetermined amount; and/or (ii) reducing a likelihood value associated with one or more possible candidate compounds in the first list if the difference between said one or more experimentally determined or measured first ion mobility values, collision cross sections or interaction cross sections collision cross sections or first ion mobility parameters and the one or more calculated, estimated or determined second ion mobility values, collision cross sections or interaction cross sections collision cross sections or second ion mobility parameters is greater than a predetermined amount.. ... Micromass Uk Limited

08/24/17 / #20170243729

Ion source

A method of ionising a sample is provided, comprising providing a fluid sample, wherein the fluid sample contains an analyte, applying one or more pulses of acoustic energy to the fluid sample to cause a spray of the fluid sample to eject from the surface of the fluid sample, and applying an ac, rf or alternating voltage to the fluid sample using an electrode.. . ... Micromass Uk Limited

08/17/17 / #20170236700

Time of flight mass spectrometer

There is provided a mass spectrometer comprising a time of flight mass analyser comprising an acceleration electrode, a time of flight region and an ion detector, and a control system arranged and adapted (i) to apply a plurality of extraction pulses to said acceleration electrode in order to accelerate consecutive groups of ions into said time of flight region, wherein ions having a relatively high mass to charge ratio in a preceding group of ions arrive at said detector after ions having a relatively low mass to charge ratio in a subsequent group of ions, wherein ions within each consecutive group of ions have a mass to charge ratio within one or more predetermined, selected or otherwise known mass to charge ratio ranges, and (ii) to determine a frequency or period of said plurality of extraction pulses that will avoid coincidence of ions from said consecutive groups of ions at said ion detector, wherein said plurality of extraction pulses are applied at said determined frequency or period.. . ... Micromass Uk Limited

08/10/17 / #20170229297

Intelligent dynamic range enhancement

A method of mass spectrometry is disclosed comprising transmitting ions and obtaining first mass spectral data and automatically determining during an acquisition whether the first mass spectral data suffers from saturation or is approaching saturation. If a determination is made during an acquisition that the first mass spectral data suffers from saturation or is approaching saturation then the method further comprises automatically changing or altering the intensity of ions which are detected by an ion detector and obtaining second mass spectral data. ... Micromass Uk Limited

08/03/17 / #20170221690

Method of introducing ions into a vacuum region of a mass spectrometer

A method of mass spectrometry or ion mobility spectrometry is disclosed. The method comprises providing a spectrometer comprising an orifice between an atmospheric pressure region and a sub-atmospheric pressure region of the spectrometer, wherein the sub-atmospheric pressure region comprises an ion guide or ion trap; providing a sample probe comprising a needle assembly on which a sample is deposited or that is supplied with a sample; inserting the needle assembly through the orifice and into the sub-atmospheric pressure region so that the sample is arranged within or adjacent to the ion guide or ion trap in the sub-atmospheric pressure region; and then desorbing the sample from the needle assembly within the sub-atmospheric pressure region and/or ionising the sample within the sub-atmospheric pressure region so as to generate ions that enter the ion guide or ion trap. ... Micromass Uk Limited

07/27/17 / #20170213716

Method for separating ions according to a physicochemical property

A method of separating ions according to a physicochemical property is disclosed. The method comprises causing ions to perform a plurality of cycles along or around an ion guiding path such that the ions separate according to said physicochemical property. ... Micromass Uk Limited

07/27/17 / #20170213713

Multipath duty cycle enhancement

A mass spectrometer is disclosed comprising a first device, a second device and a switch arranged and adapted: (i) to direct ions at a first time t1 to the first device and to substantially prevent ions from entering the second device; and (ii) to direct ions at a second later time t2 to the second device and to substantially prevent ions from entering the first device. At the first time t1 the second device may not be in an operational state to potentially optimally fragment, react, mass filter or otherwise process ions since the second device may be in a process of equilibration, changing state, re-filling, recharging, transition, replenishing, switching voltage or altering an operational parameter. ... Micromass Uk Limited

07/27/17 / #20170212081

Mobility selective attenuation

A method of mass spectrometry is disclosed comprising separating a first population of ions according to their ion mobility and selectively attenuating ions in the first population of ions in one or more ion mobility and/or drift time ranges so as to form a second population of ions. The step of selectively attenuating ions comprises applying a varying, increasing or decreasing attenuation factor to ions in different ion mobility and/or drift time ranges. ... Micromass Uk Limited

07/20/17 / #20170207073

Histogramming different ion areas on peak detecting analogue to digital convertors

A method of mass spectrometry is disclosed comprising digitising a first signal output from an ion detector to produce a first digitised signal, detecting one or more peaks in the first digitised signal and determining a first area s0 or a first intensity i0 of the one or more peaks and a first arrival time t0 of the one or more peaks thereby forming a first list of data pairs and determining whether or not the first area s0 or the first intensity i0 exceeds a first threshold area smax or a first threshold intensity imax. The first threshold area smax and the first threshold intensity imax correspond respectively to a peak area and a peak intensity indicative of substantially simultaneous arrival of two ions which the ion detector is unable to resolve. ... Micromass Uk Limited

07/20/17 / #20170207072

Method of mass spectrometry and a mass spectrometer

The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring the parent and fragmentation ions from two or more different areas of the sample and identifying changes in the number of parent ions between the areas in the sample, and corresponding changes in the number of fragmentation ions between the two areas.. ... Micromass Uk Limited

07/13/17 / #20170200597

Ion guide

An ion guide is disclosed comprising a first array of electrodes and a second array of electrodes and one or more apertures or ion exit regions. The first array of electrodes comprises a first plurality of arcuate electrodes arranged in parallel with one another and such that said first plurality of arcuate electrodes at least partially surround said one or more apertures or ion exit regions and/or wherein said second array of electrodes comprises a second plurality of arcuate electrodes arranged in parallel with one another and such that said second plurality of arcuate electrodes at least partially surround said one or more apertures or ion exit regions. ... Micromass Uk Limited

07/13/17 / #20170200595

Ion mobility separation device

An ion mobility separator and a method of separating ions according to their ion mobility are disclosed. An rf ion guide is provided having a plurality of electrodes that are arranged to form an ion guiding path that extends in a closed loop. ... Micromass Uk Limited

07/13/17 / #20170200594

Hybrid mass spectrometer

A method of mass spectrometry is disclosed comprising separating ions temporally in a first device and analysing the mass or mass to charge ratio of the ions or of product or fragment ions derived from the ions in a mass or mass to charge ratio analyser disposed downstream of the first device. The method further comprises obtaining a first set of drift times for the ions through the first device by measuring ion arrival times and determining the transit time of the ions and/or of the product or fragment ions through one or more intermediate regions or devices disposed between the first device and the mass to charge ratio analyser. ... Micromass Uk Limited

07/13/17 / #20170199153

Segmented linear ion mobility spectrometer driver

An ion mobility spectrometer or separator is disclosed comprises plural groups of electrodes, each group of electrodes comprising: (i) a first electrode connected to a first independently controllable voltage supply; (ii) one or more intermediate electrodes; and (iii) a second electrode connected to a second independently controllable voltage supply, wherein the first electrode, the one or more intermediate electrodes and the second electrode are interconnected by a series of resistors or other components so as to form a resistive divider so that the potential of the one or more intermediate electrodes is determined by the voltages supplied by the first and second voltage supplies and the resistance of the resistors; a drift region; a first device arranged and adapted to pulse a packet of ions into the drift region so that the ions are caused to separate temporally and assume one or more ion distributions; and a control system arranged and adapted: (i) to cause at least some of the independently controllable voltage supplies to supply voltages to at least two adjacent groups of electrodes so as to substantially continuously subject at least part or substantially the whole of the one or more ion distributions to a first non-zero voltage gradient or a first non-zero constant or linear electric field as the one or more ion distributions progress along the drift region; and (ii) to cause at least some of the independently controllable voltage supplies to supply voltages to groups of electrodes other than the at least two adjacent groups of electrodes to create, maintain or apply a second different voltage gradient or a second different electric field across one or more portions of the drift region which are distal from the one or more ion distributions.. . ... Micromass Uk Limited

06/29/17 / #20170186594

Monitoring liquid chromatography elution to determine when to perform a lockmass calibration

A method of mass spectrometry is disclosed that comprises acquiring mass spectral data during a single experimental run or acquisition of a mass spectrometer and determining a first time t during the single experimental run or acquisition for calibrating the mass spectrometer. The step of determining the first time t further comprises determining a time when the mass spectral data being acquired during the single experimental run or acquisition is equal to or below a threshold. ... Micromass Uk Limited

06/29/17 / #20170184616

Separating and quantifying thiamine pyrophosphate and pyridoxal 5-phosphate in human whole blood

The present disclosure provides robust, high-throughput, and clinically applicable methods for simultaneously separating and quantifying the biologically active forms of vitamin b1 (tpp) and vitamin b6 (plp) from human whole blood.. . ... Micromass Uk Limited

06/29/17 / #20170184547

Mass spectrometer

A mass spectrometer is disclosed comprising a first ion trap or ion guide, a single ion mobility spectrometer or separator stage and a second ion trap or ion guide arranged downstream of the ion mobility spectrometer or separator. In a mode of operation ions from the second ion trap or ion guide are passed from the second ion trap or ion guide back upstream to the ion mobility spectrometer or separator.. ... Micromass Uk Limited

06/22/17 / #20170178886

Ion guide construction method

A method of constructing an ion guide is disclosed comprising providing an elongated spine member and a plurality of plates. Each plate comprises an aperture therethrough for receiving the spine member and at least one electrode for use in guiding ions. ... Micromass Uk Limited

06/22/17 / #20170178880

Two dimensional ms/ms acquisition modes

A method of mass spectrometry is disclosed comprising performing a plurality of experimental runs, wherein each experimental run comprises: periodically mass analysing fragment or product ions at a plurality of time intervals, wherein a delay time is provided between the start of the experimental run and the first time interval at which the fragment or product ions are mass analysed. Different delay times are provided in different ones of the experimental runs and fragment or product ions that have been analysed in the same time interval in at least one of said experimental runs and that have been analysed in different time intervals in at least one other of said experimental runs are identified as fragment or product ions of interest. ... Micromass Uk Limited

06/22/17 / #20170176401

Secondary ultrasonic nebulisation

A secondary ultrasonic nebulisation device is disclosed comprising: a liquid sample delivery capillary; a sample receiving surface arranged for receiving a liquid sample from the capillary; and an ultrasonic transducer configured for oscillating the surface so as to nebulise the liquid sample received thereon, wherein the device is configured such that the oscillations of the surface by the ultrasonic transducer cause charged droplets and/or gas phase ions to be generated from the sample.. . ... Micromass Uk Limited

06/15/17 / #20170169999

Compact mass spectrometer

A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. ... Micromass Uk Limited

06/08/17 / #20170162374

Improved quadrupole robustness

An apparatus for filtering ions is disclosed comprising a separation device for separating ions temporally according to a first physico-chemical property and a first quadrupole rod set for filtering ions according to their mass to charge ratio, wherein the first quadrupole rod set comprises a plurality of rods and wherein the first quadrupole rod set is arranged downstream of the separation device. The apparatus further comprises a control system arranged and adapted during a single cycle of separation of the separation device: (i) to operate the first quadrupole rod set in a first resolving mode of operation wherein ions of interest are selected by the first quadrupole rod set; and (ii) to operate the first quadrupole rod set in a second non-resolving or transmission mode of operation at separation times when substantially no ions of interest are present so that substantially no ions impact upon the rods of the first quadrupole rod set.. ... Micromass Uk Limited

05/18/17 / #20170140916

Ion trap with spatially extended ion trapping region

A mass or mass to charge ratio selective ion trap is disclosed which directs ions into a small ejection region. A rf voltage acts to confine ions in a first (y) direction within the ion trap. ... Micromass Uk Limited

05/18/17 / #20170140910

Photo-dissociation of proteins and peptides in a mass spectrometer

A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2d or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected. ... Micromass Uk Limited

05/18/17 / #20170140908

Ion mobility spectrometry data directed acquisition

A method of analysing ions, comprising performing an initial multidimensional survey scan comprising separating parent ions according to a first physico-chemical property and separating said parent ions according to a second physico-chemical property, producing a two-dimensional data set comprising data corresponding to said first physico-chemical property and data corresponding to said second physico-chemical property, identifying one or more target ion species of interest and determining a mode of operation of a mass spectrometer for said target ion species of interest using data relating to said target ion species of interest in said two-dimensional data set, wherein said mode of operation comprises the location of fragmentation of said target ions of interest.. . ... Micromass Uk Limited

05/18/17 / #20170138915

Staggered chromatography mass spectrometry

An analytical instrument is disclosed comprising a liquid chromatography system comprising a first column, a chromatographic delay line and a splitter arranged and adapted in a mode of operation to split eluent from the first column into a first portion of eluent and a second portion of eluent. The instrument further comprises a first device. ... Micromass Uk Limited

05/11/17 / #20170133213

Method of transmitting ions through an aperture

A mass spectrometer is disclosed comprising: an ion source; an aperture; a flight region arranged between the ion source and aperture for separating ions according to their mass to charge ratio; and ion optics arranged and configured for causing ions to be reflected or deflected whilst they separate according to mass to charge ratio in the flight region and such that the ions are focussed to a geometrical focal point at the aperture so that the ions are transmitted through the aperture. The multi-reflecting or multi-deflecting ion optics provides a relatively long flight path for the ions, whilst naturally converging the ion beam to a focus. ... Micromass Uk Limited

05/11/17 / #20170133211

Time shift for improved ion mobility spectrometry or separation digitisation

A method of analysing ions is disclosed comprising: (i) separating ions according to a physico-chemical property in a separator; (ii) transmitting ions which emerge from the separator through a transfer device with a first transit time t1, energising a pusher electrode or orthogonal acceleration electrode and obtaining first data; (iii) transmitting ions which subsequently emerge from the separator through the transfer device with a second greater transit time t2, energising the pusher electrode or orthogonal acceleration electrode and obtaining second data; and (iv) repeating steps (ii) and (iii) one or more times. The pusher electrode or orthogonal acceleration electrode is energised with a period t3, wherein t2−t1 is arranged to equal t3/2. ... Micromass Uk Limited

05/11/17 / #20170131290

Fast method to analyse blood samples for the identification of hemoglobin variants using electron transfer dissociation

A method of screening or testing a sample is disclosed that comprises ionising a native human hemoglobin sample to generate parent or precursor ions, subjecting the parent or precursor ions to electron transfer dissociation fragmentation so as to generate a plurality of fragment ions, mass analysing the fragment ions and determining whether or not the fragment ions include fragment ions which are indicative of a variant of hemoglobin.. . ... Micromass Uk Limited

05/11/17 / #20170131238

Confirmation using multiple collision cross section ("ccs") measurements

A method of identifying ions or confirming the identity of ions is disclosed comprising determining a physico-chemical or other property of first ions under first conditions, determining the physico-chemical or other property of the first ions or second ions derived from the first ions under second different conditions, and identifying or confirming the identity of the first ions or determining a class of the first or the second ions on the basis of the physico-chemical or other property of the first ions as determined under the first conditions and on the basis of the physico-chemical or other property of the first ions or second ions derived from the first ions as determined under the second conditions.. . ... Micromass Uk Limited

05/04/17 / #20170125235

Ion profiling with a scanning quadrupole mass filter

A mass spectrometer is disclosed comprising an ion mobility separation device for separating ions according to their ion mobility, a first quadrupole mass filter downstream of the ion mobility separation device, a control system arranged and adapted to scan and/or step the set mass of the first quadrupole mass filter a plurality of times over a first mass to charge ratio range of <±2 amu during the elution time of an ion mobility peak from the ion mobility separation device, and an analyser or ion detector downstream of the first quadrupole mass filter arranged and adapted to analyse or detect ions so as to acquire multi-dimensional ion mobility-mass to charge ratio data.. . ... Micromass Uk Limited

05/04/17 / #20170125232

Secondary electrospray ionization at reduced pressure

A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing gas phase analyte in a vacuum housing; electrospraying a reagent solution outside of the vacuum housing so as to form charged droplets of reagent solution and/or reagent ions; conveying the charged droplets and/or reagent ions into the vacuum housing and reacting them with the analyte so as to form analyte ions; and analysing the analyte ions with a mass analyser and/or ion mobility analyser. Reacting the droplets of reagent solution and/or reagent ions with the analyte in sub-atmospheric pressures improved the reaction conditions.. ... Micromass Uk Limited

05/04/17 / #20170125231

A method of compressing an ion beam

A method of mass or ion mobility spectrometry is disclosed comprising: releasing ions from an ion trapping volume into an ion separation region; separating the ions along a longitudinal direction according to a physicochemical property; and compressing the ion beam in a direction orthogonal to the longitudinal axis. The method enables the ions to be focussed without increasing the charge density and hence space-charge effects to undesirable levels.. ... Micromass Uk Limited

05/04/17 / #20170125229

Ion entry/exit device

A method of introducing and ejecting ions from an ion entry/exit device (4) is disclosed. The ion entry/exit device (4) has at least two arrays of electrodes (20,22). ... Micromass Uk Limited

05/04/17 / #20170125226

Time of flight detection system

A ion detector system for a mass spectrometer is disclosed comprising a detector comprising an array of sensor pixels, wherein a dimension of the sensor pixels is <about 10 μm, and an aperture arranged and adapted such that a beam of charged particles or light passes through the aperture in use, wherein the aperture comprises a pinhole aperture or slit having a dimension comparable to, equal to, or less than the dimension of the sensor pixels.. . ... Micromass Uk Limited

05/04/17 / #20170125225

Method of generating ions of high mass to charge ratio by charge reduction

A method of charge stripping analyte ions is disclosed. The method comprises reacting the analyte ions with reagent ions or charged particles; and then urging the reacted analyte ions through a neutral, inert gas such that said analyte ions interact or collide with the gas molecules in a manner that reduces the charge state of the reacted analyte ions, thereby forming product ions of reduced charge state. ... Micromass Uk Limited

05/04/17 / #20170125224

Method of identifying precursor ions

A method of mass spectrometry is disclosed comprising mass selectively transmitting precursor ions from a mass analyser into a fragmentation or reaction device, wherein the mass to charge ratios of the ions transmitted varies with time; fragmenting the precursor ions in the fragmentation or reaction device so as to produce fragment or product ions; mass analysing the fragment or product ions; determining the start and end times at which a first fragment or product ion is detected; using said start and end times to determine the start and end times at which a precursor ion of said first fragment or product ion is transmitted by said mass analyser; and using the start and end times at which the precursor ion is transmitted by said mass analyser to determine a mass to charge ratio of said precursor ion. The present invention enables precursor ion peaks to be resolved from the fragment data even when a low resolution mass analyser is used to analyse the precursor ions.. ... Micromass Uk Limited

05/04/17 / #20170125222

Self-calibration of spectra using differences in molecular weight from known charge states

A method of calibrating a mass spectrometer is disclosed comprising mass analysing first ions derived from an analyte molecule, wherein the first ions have a first charge state; determining a first mass or mass to charge ratio of the first ions; mass analysing second ions derived from the analyte molecule, wherein the second ions have a second different charge state and wherein the second ions comprise protonated or adduct variants of the first ions; determining a second mass or mass to charge ratio of the second ions; a determining a calibration correction based upon the first mass or mass to charge ratio and the second mass or mass to charge ratio.. . ... Micromass Uk Limited

05/04/17 / #20170122907

Controlling gas-phase ion interactions

A mass spectrometer or ion mobility spectrometer is disclosed comprising: a first device for separating ions or molecules according to a physicochemical property; an ion mobility separation device for receiving and separating at least some of said ions or ions derived from said molecules according to their ion mobility; a gas supply connected to said ion mobility separation device for supplying gas into said ion mobility separation device; and a control system configured to adjust said gas supply so as to change the composition of gas within the ion mobility separation device as a function of time.. . ... Micromass Uk Limited

04/27/17 / #20170117129

Monitoring ion mobility spectrometry environment for improved collision cross section accuracy and precision

A mass spectrometer is disclosed comprising an ion mobility separator for separating ions according to their ion mobility, one or more first devices or stages arranged upstream of the ion mobility separator and a control system. The control system is arranged and adapted to monitor directly or indirectly the operating environment within the ion mobility separator, and to control the operating environment within the ion mobility separator based on the monitoring by controlling one or more gas flows to or within one or more of the one or more first devices or stages.. ... Micromass Uk Limited

04/27/17 / #20170117125

Liquid extraction matrix assisted laser desorption ionisation ion source

A matrix assisted laser desorption ionisation (“maldi”) ion source is disclosed comprising a first device arranged and adapted to supply a flow of liquid on to the surface of a target or a sample to be analysed so that the liquid forms a liquid junction on the surface of the target or the sample to be analysed and wherein analyte molecules to be ionised are extracted into the liquid junction, and a laser source emits a laser beam which causes analyte ions or an analyte plume to be released or desorbed from the liquid junction.. . ... Micromass Uk Limited

04/20/17 / #20170110310

Synchronised variation of source conditions of an atmospheric pressure chemical ionisation mass spectrometer coupled to a gas chromatograph to improve stability during analysis

A mass spectrometer is disclosed comprising a gas chromatography separation device, an atmospheric pressure ionisation ion source and a control system arranged and adapted: (i) to operate the atmospheric pressure ionisation ion source at one or more first settings for a first period of time whilst one or more solvents elute from the gas chromatography separation device during a solvent front; and then (ii) to operate the atmospheric pressure ionisation ion source at one or more second different settings for a second subsequent period of time whilst one or more analytes elute from the gas chromatography separation device.. . ... Micromass Uk Limited

04/20/17 / #20170110304

Processing mass spectral data

A method of mass spectrometry is disclosed that comprises transforming mass spectral data to produce frequency-domain mass spectral data, modifying the frequency-domain mass spectral data to produce modified frequency-domain mass spectral data by attenuating and/or removing one or more ranges of the frequency-domain mass spectral data that relate to noise associated with peaks of interest in the mass spectral data, and transforming the modified frequency-domain mass spectral data to produce modified mass spectral data.. . ... Micromass Uk Limited

04/20/17 / #20170110303

Combined tandem mass spectrometry and ion mobility mass spectrometry

A method of analysing ions is disclosed comprising performing an initial multi-dimensional survey scan comprising separating parent ions according to a first physico-chemical property and separating the parent ions according to a second physico-chemical property. At least one parent ion of interest from the initial multi-dimensional survey scan is determined, the at least one parent ion of interest having a first value or range of the first physico-chemical property and a second value or range of the second physico-chemical property. ... Micromass Uk Limited

04/13/17 / #20170102361

Optimised ion mobility separation timescales for targeted ions

An analytical device for analysing ions is provided comprising a separator for separating ions according to a physico-chemical property and an interface comprising one or more ion guides. A quadrupole rod set mass filter is arranged downstream of the interface. ... Micromass Uk Limited

04/06/17 / #20170098531

Flagging adc coalescence

A method of mass spectrometry is disclosed comprising digitising at least one individual signal or transient, determining in relation to the digitised signal or transient an indication of overlap and/or coalescence of ion arrivals in the digitised signal or transient, or one or more ion arrival envelopes in the digitised signal or transient, and marking or flagging the digitised signal or transient as suffering from overlap or coalescence of ion arrivals based on the indication.. . ... Micromass Uk Limited

03/30/17 / #20170092477

Ion guide

An ion guide comprises a first ion guide portion that forms a first ion guiding path and a second ion guide portion that forms a second ion guiding path. A first device applies a plurality of different first voltages or potentials to the electrodes of the first ion guide portion in order to generate an electric field that directs ions from the first ion guiding path of the first ion guide portion into the second ion guiding path of the second ion guide portion. ... Micromass Uk Limited

03/30/17 / #20170092475

Method of generating electron transfer dissociation reagent ions

A method of mass spectrometry is disclosed wherein ions are subjected to an electron detachment, electron capture or electron transfer process in order to form ions having a different charge state. At least some of the ions having a different charge state are caused to interact with analyte ions to cause at least some of the analyte ions to fragment to form daughter, fragment or product ions.. ... Micromass Uk Limited

03/30/17 / #20170089862

Mass spectrometer

A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells. ... Micromass Uk Limited

03/23/17 / #20170082435

Ion source alignment

An ion analysis instrument is disclosed comprising an indicator device for providing an indication of a relative positioning of an ion source, a sample, and/or a sampling orifice or capillary of an ion analysis instrument such as a mass or ion mobility spectrometer in order to facilitate re-alignment of one or more of these components following a change. The indicator device comprises a source of electromagnetic radiation such as a pair of lasers or image projection devices.. ... Micromass Uk Limited

03/16/17 / #20170076929

Multi-dimensional ion separation

A method of mass spectrometry is disclosed comprising separating first ions according to a first physico-chemical property in a first separator wherein at least some of the first ions undergo a different number of cycles or passes within the separator and separating the first ions which emerge from the first separator according to a second physico-chemical property wherein the second physico-chemical property is correlated with the first physico-chemical property. The method further comprises determining the second physico-chemical property of the first ions and determining, assigning or de-convolving the first physico-chemical property of the first ions based upon the determined second physico-chemical property of the first ions.. ... Micromass Uk Limited

03/16/17 / #20170076927

Using theoretical collision cross section ("ccs") in sample identification

A method of mass spectrometry is disclosed that comprises predicting 1 one or more first reaction products which may result from subjecting an analyte to one or more reactions of interest, calculating 2 one or more first masses or mass to charge ratios and one or more first ion mobility values, collision cross sections or interaction cross sections of at least some first reaction product ions which may be generated from the one or more first reaction products under first conditions, and calculating one or more second masses or mass to charge ratios and one or more second ion mobility values, collision cross sections or interaction cross sections of at least some second reaction product ions which may be generated from the one or more first reaction products under second different conditions. The method further comprises generating third ions from a sample under the first conditions, generating fourth ions from the sample under the second conditions, experimentally determining 3 one or more third masses or mass to charge ratios and one or more third ion mobility values, collision cross sections or interaction cross sections of at least some of the third ions, and experimentally determining one or more fourth masses or mass to charge ratios and one or more fourth ion mobility values, collision cross sections or interaction cross sections of at least some of the fourth ions. ... Micromass Uk Limited

03/16/17 / #20170076926

De-convolution of overlapping ion mobility spectrometer or separator data

A method of mass spectrometry is disclosed comprising separating first ions according to a first physico-chemical property in a first separator wherein at least some of the first ions undergo a different number of cycles or passes within the separator and separating the first ions which emerge from the first separator according to a second physico-chemical property wherein the second physico-chemical property is correlated with the first physico-chemical property. The method further comprises determining the second physico-chemical property of the first ions and determining, assigning or de-convolving the first physico-chemical property of the first ions based upon the determined second physico-chemical property of the first ions.. ... Micromass Uk Limited

03/09/17 / #20170069479

Ambient ionisation with an impactor spray source

An ion source is disclosed comprising a nebuliser arranged and adapted to emit a liquid spray, a first target arranged downstream of the nebuliser, wherein the liquid spray is arranged to impact upon the first target, and a sample target arranged downstream of the first target, wherein a sample to be analysed is provided at the sample target.. . ... Micromass Uk Limited

03/09/17 / #20170069478

Glow discharge ion source

A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode located within an isolation valve, which is provided in the vacuum chamber. ... Micromass Uk Limited

03/09/17 / #20170069477

Ion guide with orthogonal sampling

A mass spectrometer is disclosed comprising a rf ion guide wherein in a mode of operation a continuous, quasi-continuous or pulsed beam of ions is orthogonally sampled from the ion guide and wherein the continuous, quasi-continuous or pulsed beam of ions is not axially trapped or otherwise axially confined within the rf ion guide. The ion guide is maintained, in use, at a pressure selected from the group consisting of: (i) 0.0001-0.001 mbar; (ii) 0.001-0.01 mbar; (iii) 0.01-0.1 mbar; (iv) 0.1-1 mbar; (v) 1-10 mbar; (vi) 10-100 mbar; and (vii) >100 mbar.. ... Micromass Uk Limited

03/09/17 / #20170069475

Hybrid acquisition method incorporating multiple dissociation techniques

A method is disclosed wherein parent or precursor ions are fragmented or reacted according to a first fragmentation or reaction mode, and when an ion of interest is detected the method then temporarily switches to a second mode of fragmentation or reaction. This enables a full un-biased ms/ms data set to be provided over a wide mass to charge ratio range with high-duty cycle, together with complementary detailed fragment data of interest, in a single experimental run or acquisition.. ... Micromass Uk Limited

03/02/17 / #20170062199

Identification and removal of chemical noise for improved ms and ms/ms analysis

A method of mass spectrometry is disclosed comprising mass analysing ions and obtaining mass spectral data and determining parent or precursor ions of interest. The method further comprises determining first adduct or chemical artefact ions which have mass to charge ratios which have a substantially linear relationship with the mass to charge ratio of the parent or precursor ions of interest and removing or attenuating the first adduct or chemical artefact ions from the mass spectral data.. ... Micromass Uk Limited

03/02/17 / #20170062197

Mass spectrometer with digital step attenuator

A method is disclosed comprising passing a signal output from a detector through a programmable attenuator or a programmable amplifier prior to digitising the signal, and switching an attenuation factor or gain factor of the programmable attenuator or the programmable amplifier one or more times during a data acquisition period.. . ... Micromass Uk Limited

03/02/17 / #20170059525

Flushing ion mobility separation cell between ion mobility separation cycles

An apparatus is provided to separate ions temporally according to a physico-chemical property comprising an ion guide comprising a plurality of electrodes and a first device arranged and adapted to remove undesired ions remaining within the ion guide after ions of interest have exited the ion guide.. . ... Micromass Uk Limited

02/23/17 / #20170053786

Mass spectrometer data acquisition

A data acquisition system for a tof mass spectrometer comprises a processing module and a data collection module. The processing module generates a stream of data comprising, for each respective transient of a first scan, a set of time-intensity related parameter pairs. ... Micromass Uk Limited

02/23/17 / #20170053785

Mass spectrometer with reduced potential drop

A method of mass spectrometry is disclosed comprising providing a first device and a second device disposed downstream of the first device. The method further comprises introducing a potential difference between the exit of the first device and the entrance of the second device and reducing the total potential drop across the first and second devices by applying a reverse axial electric field to the first device and/or the second device. ... Micromass Uk Limited

02/16/17 / #20170047211

Method of localizing lipid double bonds

A method of mass spectrometry for analysing lipids and similar biological molecules is disclosed. The lipid molecules may be ionised to form a plurality of lipid parent ions and subjected to photon-induced fragmentation to form a plurality of fragment or product ions. ... Micromass Uk Limited

02/16/17 / #20170047208

Self-calibration of spectra using precursor mass to charge ratio and fragment mass to charge ratio known differences

A method of checking or adjusting the calibration of a mass spectrometer is disclosed. The method comprises fragmenting parent or precursor ions and generating fragment or product ion mass spectral data and recognising first neutral loss ions in the fragment or product ion mass spectral data. ... Micromass Uk Limited

02/02/17 / #20170032954

High pressure mass resolving ion guide with axial field

A mass spectrometer is disclosed comprising a first mass filter comprising a plurality of electrodes and a first device arranged and adapted to generate an axial force which drives at least some ions axially through or along the first mass filter and a quadrupole mass filter or mass analyser arranged downstream of the mass filter.. . ... Micromass Uk Limited

02/02/17 / #20170032951

Orthogonal acceleration coaxial cylinder mass analyser

A mass analyser is disclosed comprising an annular ion guide comprising a first annular ion guide section and a second annular ion guide section, wherein the annular ion guide comprises: (i) an inner cylindrical electrode arrangement which is axially segmented and comprises a plurality of first electrodes and (ii) an outer cylindrical electrode arrangement which is axially segmented and comprises a plurality of second electrodes. Ions are introduced into the first annular ion guide section so that the ions form substantially stable circular orbits. ... Micromass Uk Limited

01/26/17 / #20170025260

Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis

A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as hydrogen-deuterium exchange. ... Micromass Uk Limited

01/19/17 / #20170018414

Microwave cavity resonator detector

An ion detector system for a mass spectrometer is disclosed comprising a first device arranged and adapted to receive ions and emit or output first electrons and a microwave cavity resonator arranged and adapted to deflect the first electrons onto a first detector.. . ... Micromass Uk Limited

01/12/17 / #20170011899

Method of optimising spectral data

A method of mass spectrometry or ion mobility spectrometry is disclosed. The method comprises: providing a plurality of species of ions; analysing the ions during a plurality of sequential acquisition periods so as to obtain spectral data relating to the ions; varying the value of an operational parameter of the spectrometer such that it has different values during the different acquisition periods, wherein the spectral data obtained for a given ion varies depending on the value of the operational parameter; storing the spectral data obtained during the different acquisition periods separately; selecting a target ion; and then interrogating the spectral data so as to identify a set of first acquisition periods that include data corresponding to said target ion. ... Micromass Uk Limited

01/05/17 / #20170003250

Method of charge state selection

A method of mass spectrometry or ion mobility spectrometry is disclosed in which analyte ions of a desired charge state are isolated. The method comprises: separating analytes according to their electrophoretic mobility; ionising the analytes; and mass filtering the resulting analyte ions, wherein the mass to charge ratios of the ions transmitted by a mass filter are varied as a function of the electrophoretic mobility and according to a predetermined relationship such that substantially only ions having said desired charge state are transmitted by the mass filter.. ... Micromass Uk Limited








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