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Nanobio Corporation patents


Recent patent applications related to Nanobio Corporation. Nanobio Corporation is listed as an Agent/Assignee. Note: Nanobio Corporation may have other listings under different names/spellings. We're not affiliated with Nanobio Corporation, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "N" | Nanobio Corporation-related inventors


 new patent  Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents

The present application discloses methods and apparatuses for single molecule drug screening, discovery and validation. These methods and apparatuses allow a user to detect rapidly, using observation of single molecules, whether and how a drug candidate interferes with a target enzyme involved in a particular disease pathway. ... Nanobio Corporation

Nanoparticles for use as a therapeutic vaccine

The present invention relates to the field of human health and more particularly concerns nanoparticles for use as a therapeutic vaccine in the context of radiotherapy in a subject suffering of a cancer, in particular of a metastatic cancer or of a liquid cancer.. . ... Nanobio Corporation

Immunogenic compositions for use in vaccination against bordetella

The present application relates to immunogenic compositions comprising a mixture of bordetella (e.g., b. Pertussis) antigens and an oil in water nanoemulsion. ... Nanobio Corporation

Process for forming a solution containing gold nanoclusters binding with ligands

The present invention discloses a process for forming a solution containing gold nanoclusters binding with ligands, the process comprises the following steps: provide a aqueous solution that comprises a gold precursor, a base and ligands; perform a reduction reaction by adding a reductant into the aqueous solution to form a liquid containing gold nanoclusters binding with the ligands; concentrate the liquid containing the gold nanoclusters binding with the ligands to a solid; dissolve the solid into water to form a crude solution; and perform a purification process by passing the crude solution through a membrane or a dialysis tube to obtain the solution containing the gold nanoclusters binding with the ligands.. . ... Nanobio Corporation

System and method of measuring cell viability and growth

A novel sh-saw biosensor capable of non-invasive and touch-free detection of cancer cell viability and growth or proliferation in two-dimensional (2d) and three-dimensional (3d) cell cultures as well as stem cell regeneration as it pertains to cancer cell biology and anti-cancer drug development is presented. The biosensor includes two pairs of resonators including interdigital transducers reflecting fingers to quantify mass loading by the cells in suspension as well as within a tumoroid culture platform. ... Nanobio Corporation

Sealing device of microfluidic chip and operation method therefor

According to one embodiment of the present invention, a sealing device of a microfluidic chip and an operation method therefor are provided. The device can comprise: a support part in which the microfluidic chip is arranged; and a heat sealing part applying heat to an inlet part and an outlet part of the microfluidic chip so as to seal the inlet part and the outlet part.. ... Nanobio Corporation

Compositions and methods for inducing nanoparticle mediated microvascular embolization of tumors

Nanoparticle mediated microvascular embolization (nme) of tumor tissue may occur after systemic administration of pem, leading to widespread shutdown of vascular flow, hemorrhage, and necrosis. Pem constructs are developed that incorporate large amounts of iron-containing protein, possess high oxygen affinities, and demonstrate delayed nitric oxide binding. ... Nanobio Corporation

Nanoemulsion respiratory syncytial virus (rsv) subunit vaccine

The present application relates to the field of immunology, in particular, a vaccine composition of respiratory syncytial virus (rsv) surface proteins, fusion (f) and glycoprotein (g) proteins subunit vaccine preferentially mixed with the immune cell targeting and enhancer, nanoemulsion to induce a protective immune response and avoid vaccine-induce disease enhancement.. . ... Nanobio Corporation

Compositions and methods for inducing nanoparticle-mediated microvascular embolization of tumors

Nanoparticle mediated microvascular embolization (nme) of tumor tissue may occur after systemic administration of pem as a result of the nitric oxide sequestration by pem. Nitric oxide sequestration may cause a reduction in available extracellular nitric oxide in the tumor endothelium, which may prompt a widespread shutdown of vascular flow, hemorrhage, and necrosis. ... Nanobio Corporation

Nucleic acid extraction appratus and operation method thereof

In accordance with one embodiment of the present invention, there is disclosed an apparatus for nucleic acid extraction and an operation method thereof. The apparatus for nucleic acid extraction includes: a first rack having a plurality of sample tube receivers arranged in a circle; a second rack having a plurality of elution tube receivers arranged in a circle on an outer side thereof and a washing solution receiver positioned at the center thereof, a part of the washing solution receiver extending outwards to have projections formed in alternation with a plurality of the elution tube receivers; a main body having the first and second racks arranged to position the first rack on the top of the second rack; a rotational driver for separately rotating the first and second racks; a dispenser for separately dispensing a washing solution and an eluting solution into sample tubes; and a pressurizer for maintaining the inside of the sample tubes under raised pressure.. ... Nanobio Corporation

Pcr apparatus comprising repeated sliding means and pcr method using same

One embodiment of the present invention relates to a pcr apparatus comprising a repeated sliding means and a pcr method using same. According to the present invention, the throughput of samples can be increased by simultaneously, rapidly, and accurately performing a pcr on the large number of samples through repeated thermal contact between a pcr heating block having two or more heaters disposed therein and a pcr chip having two or more reaction chambers disposed therein. ... Nanobio Corporation

Two-color fluorescence localization super-resolution biological microscopy method and system

A two-color fluorescence localized super-resolution biological microscopy method and system are disclosed. The method includes: performing two-color fluorescence labeling on a biological sample by using alexa647 and alexa750 fluorescent molecules or cy5 and cy7 fluorescent molecules, and soaking the biological sample in an imaging buffer solution; illuminating the biological sample by laser to generate a flashing fluorescent signal of a first channel and a flashing fluorescent signal of a second channel respectively; constructing a super-resolution image of a first biological structure and a super-resolution image of a second biological structure respectively; and aligning the super-resolution image of the first biological structure and the super-resolution image of the second biological structure so as to construct a super-resolution image of a third biological structure. ... Nanobio Corporation

Pharmaceutical composition, preparation and uses thereof

The invention relates to a pharmaceutical composition comprising the combination of (i) at least one biocompatible nanoparticle, said biocompatible nanoparticle comprising at least one oligomer of albumin (n≧2) or consisting in an oligomer of albumin, and of (ii) at least one compound of interest, typically at least one pharmaceutical compound, to be administered to a subject in need of such at least one compound of interest, wherein the at least one nanoparticle potentiates the at least one compound of interest efficiency. The longest dimension of the biocompatible nanoparticle is typically between about 4 and about 500 nm. ... Nanobio Corporation

Pharmaceutical composition, preparation and uses thereof

The present invention relates to a pharmaceutical composition comprising the combination of (i) at least one biocompatible nanoparticle and (ii) at least one carrier comprising at least one pharmaceutical compound, to be administered to a subject in need of such a pharmaceutical compound, wherein the combination of the at least one biocompatible nanoparticle and of the at least one carrier comprising the pharmaceutical compound(s) potentiates the compound(s) of interest efficiency. The longest dimension of the biocompatible nanoparticle is typically between about 4 and about 500 nm and its absolute surface charge value is of at least 10 mv (. ... Nanobio Corporation

09/14/17 / #20170258720

Pharmaceutical compositions, preparation and uses thereof

The present disclosure generally relates to the field of medicine. The present invention more specifically relates to a pharmaceutical composition comprising the combination of (i) at least one biocompatible nanoparticle comprising, or consisting in, at least one natural compound which is an inhibitor of a human cyp enzyme, the longest dimension of said nanoparticle being of at least 4 nm and less than 100 nm, and (ii) at least one compound of interest, typically at least one pharmaceutical compound, to be administered to a subject in need of such at least one compound of interest, wherein the combination of the at least one biocompatible nanoparticle and of the at least one compound of interest potentiates the at least one compound of interest's bioavailability. ... Nanobio Corporation

09/14/17 / #20170258718

Pharmaceutical composition, preparation and uses thereof

The present invention relates to a pharmaceutical composition comprising the combination of (i) at least one biocompatible nanoparticle and (ii) at least one pharmaceutical compound, to be administered to a subject in need of such a pharmaceutical compound, wherein the nanoparticle potentiates the pharmaceutical compound efficiency. The longest dimension of the biocompatible nanoparticle is typically between about 4 and about 500 nm, its absolute surface charge value is of at least 10 mv (. ... Nanobio Corporation

09/14/17 / #20170258717

Pharmaceutical composition combining at least two distinct nanoparticles and a pharmaceutical compound, preparation and uses thereof

The present invention relates to a pharmaceutical composition comprising the combination of (i) at least two distinct biocompatible nanoparticles and (ii) at least one compound of interest, typically at least one pharmaceutical compound, to be administered to a subject in need of such at least one compound of interest, wherein the at least two distinct biocompatible nanoparticles potentiate the compound(s) of interest efficiency. The at least two biocompatible nanoparticles can be administered sequentially or simultaneously to the subject but are to be administered separately, typically with an interval of between more than about 5 minutes and about 72 hours, from the at least one compound of interest, preferably before the administration of the at least one compound of interest, to said subject. ... Nanobio Corporation

06/08/17 / #20170157614

High-speed real-time pcr device based on lab-on-a-chip for detecting food-borne bacteria to agrifood, and methods for detecting food-borne bacteria to agrifood using the same

The present invention relates to an ultra-high speed real-time pcr device on the basis of a lab-on-a-chip for detecting bacteria that causes food poisoning pertaining to agricultural food and a food poisoning detection method using the same. The present invention can provide a micro pcr chip which can simultaneously accommodate a plurality of small-volume samples and concurrently secure maximum thermal contact efficiency with a heating block so as to secure rapid results, and accurately measure an optical signal emitted from a nucleic acid amplification product even without any separate filtering or processing. ... Nanobio Corporation

06/08/17 / #20170157606

Microfluidic chip, manufacturing method therefor and analysis device using same

According to embodiments of the present invention, a microfluidic chip, a manufacturing method therefor and an analysis device using the same are provided. The microfluidic chip comprises: a substrate comprising an inflow part through which a fluid flows in, a fluid channel through which the fluid moves and an outflow part through which the fluid flows out; and a film attached to the substrate to protect at least one of the inflow part, the outflow part and the fluid channel from the outside, wherein the inflow part and the outflow part are implemented by penetrating through the surface of the substrate, and the fluid channel can be implemented by being sunk from the surface of the substrate.. ... Nanobio Corporation

06/01/17 / #20170151571

Multiplex pcr chip and multiplex pcr device comprising same

According to one embodiment of the present invention, a multiplex pcr device is disclosed. The multiplex pcr device comprises a multiplex pcr chip simultaneously carrying a plurality of mutually different nucleic acid molecules, and the invention may be characterised in that, attached spaced apart from each other on the multiplex pcr chip, there are a plurality of probes used for hybridization reactions whereby hybridization takes place specifically with mutually different amplified sequences of the nucleic acid molecules.. ... Nanobio Corporation

04/20/17 / #20170105929

Biodegradable nanoparticles as novel hemoglobin-based oxygen carriers and methods of using the same

Compositions of matter and methods for making, storing and administering artificial blood substitutes. Artificial blood substitutes may have oxygen carriers that encapsulate an oxygen-binding compound in a polymer vesicle. ... Nanobio Corporation

01/26/17 / #20170021354

Microfluidic chip and real-time analysis device using same

The present invention relates to a microfluidic chip and a real-time analysis device using same, and more specifically, to a microfluidic chip and a real-time analysis device using same capable of securing reliability of measurement results by appropriately preventing reduction of optical signal sensitivity due to bubbles included in a fluid. According to one embodiment of the present invention, the microfluidic chip is provided. ... Nanobio Corporation

01/12/17 / #20170008000

Pcr device having unidirectional sliding means and method for pcr using same

One embodiment of the present invention relates to a pcr device provided with a unidirectional sliding means and a method for pcr using same. According to the present invention, the amount of samples treated can be increased by simultaneously, rapidly, and accurately performing a pcr on a large number of samples through sequential thermal contact between a thermal block in which at least two heaters are repeatedly arranged and a pcr chip in which at least two reaction chambers are repeatedly arranged. ... Nanobio Corporation

01/12/17 / #20170007694

Methods and compositions for the stabilization of proteins

The present disclosure relates to buffer-stabilized protein compositions and methods of making the same. The disclosed compositions and methods provide a means of stabilizing and preserving proteins or peptides in such a way that the proteins or peptides maintain their native conformation and structure, maintain biological activity, and prevent aggregation.. ... Nanobio Corporation

01/12/17 / #20170007690

Methods and compositions for the stabilization of anthrax recombinant protective antigen

The present disclosure relates to buffer-stabilized anthrax recombinant protective antigen (rpa) compositions and methods of making the same. The disclosed compositions and methods provide a means of stabilizing and preserving rpa in such a way that the protein maintains its native conformation and structure, maintains its immunological activity, and prevents aggregation.. ... Nanobio Corporation

01/12/17 / #20170007689

Methods and compositions for nanoemulsion vaccine formulations

The present disclosure relates to nanoemulsion vaccine compositions and methods of making and using the same. The disclosed compositions and methods provide a means of treating, preventing, or protecting an individual from anthrax exposure or poisoning.. ... Nanobio Corporation

01/05/17 / #20170000743

Compositions and methods for delivery of gene editing tools using polymeric vesicles

A composition for genetic modification and a method of forming the composition, the composition may include a synthetic polymer vesicle, and a gene editing system encapsulated in the synthetic polymer vesicle. The gene editing system may include a protein component and a nucleic acid component configured to interact with a target sequence in a host cell genome.. ... Nanobio Corporation

01/05/17 / #20170000734

Compositions and methods for improved encapsulation of functional proteins in polymeric vesicles

Methods of preparing polymersome-encapsulated functional protein suspensions may include thermally blending an amount of a block copolymer with an amount of a low molecular weight polyethylene glycol (peg) for at least 30 minutes, mixing and cooling a resulting peg/polymer formulation to room temperature, adding an aliquot of a solution of the functional protein to a sample containing the peg/polymer formulation, and performing at least three dilution steps in which polymersomes that are generated are progressively saturated with the functional protein. The aliquot of the solution of the functional protein added may have a to the peg/polymer sample of around 0.5:1 to 1.5:1 by volume, and the thermal blending may be performed at 90-100° c.. ... Nanobio Corporation








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