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Natera Inc patents


Recent patent applications related to Natera Inc. Natera Inc is listed as an Agent/Assignee. Note: Natera Inc may have other listings under different names/spellings. We're not affiliated with Natera Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "N" | Natera Inc-related inventors


Systems and methods for detection of aneuploidy

Provided herein are improved methods for detecting aneuploidy in a sample. The methods in certain embodiments are used for the analysis of circulating dna in serum samples, such as circulating fetal dna or circulating tumor dna. ... Natera Inc

Systems and methods for detection of aneuploidy

Provided herein are improved methods for detecting aneuploidy in a sample. The methods in certain embodiments are used for the analysis of circulating dna in serum samples, such as circulating fetal dna or circulating tumor dna. ... Natera Inc

Detecting mutations and ploidy in chromosomal segments

The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.. ... Natera Inc

System and method for cleaning noisy genetic data and determining chromosome copy number

Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary dna, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. ... Natera Inc

System and method for cleaning noisy genetic data and determining chromosome copy number

Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary dna, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. ... Natera Inc

System and method for cleaning noisy genetic data and determining chromosome copy number

Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary dna, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. ... Natera Inc

System and method for cleaning noisy genetic data and determining chromosome copy number

Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary dna, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. ... Natera Inc

Compositions and methods for identifying nucleic acid molecules

The present disclosure provides methods and compositions for sequencing nucleic acid molecules and identifying individual sample nucleic acid molecules using molecular index tags (mits). Furthermore, reaction mixtures, kits, and adapter libraries are provided.. ... Natera Inc

Compositions and methods for identifying nucleic acid molecules

The present disclosure provides methods and compositions for sequencing nucleic acid molecules and identifying individual sample nucleic acid molecules using molecular index tags (mits). Furthermore, reaction mixtures, kits, and adapter libraries are provided.. ... Natera Inc

Compositions and methods for identifying nucleic acid molecules

The present disclosure provides methods and compositions for sequencing nucleic acid molecules and identifying individual sample nucleic acid molecules using molecular index tags (mits). Furthermore, reaction mixtures, kits, and adapter libraries are provided.. ... Natera Inc

Methods and compositions for determining ploidy

The invention provides improved methods, compositions, and kits for detecting ploidy of chromosome regions, e.g. For detecting cancer or a chromosomal abnormality in a gestating fetus. ... Natera Inc

Methods for non-invasive prenatal ploidy calling

The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a sample of dna from the mother of the fetus and from the fetus, and from genotypic data from the mother and optionally also from the father. The ploidy state is determined by using a joint distribution model to create a set of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. ... Natera Inc

Methods for non-invasive prenatal ploidy calling

The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a sample of dna from the mother of the fetus and from the fetus, and from genotypic data from the mother and optionally also from the father. The ploidy state is determined by using a joint distribution model to create a set of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. ... Natera Inc

Methods for non-invasive prenatal ploidy calling

Disclosed herein are methods for determining the copy number of a chromosome in a fetus in the context of non-invasive prenatal diagnosis. In an embodiment, the measured genetic data from a sample of genetic material that contains both fetal dna and maternal dna is analyzed, along with the genetic data from the biological parents of the fetus, and the copy number of the chromosome of interest is determined. ... Natera Inc

01/25/18 / #20180025109

Methods for non-invasive prenatal ploidy calling

The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of dna comprising dna from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. ... Natera Inc

08/24/17 / #20170242960

Methods for non-invasive prenatal ploidy calling

The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of dna comprising dna from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. ... Natera Inc

06/22/17 / #20170177786

Method for non-invasive prenatal testing using parental mosaicism data

Provided herein are methods for determining the ploidy state of one or more chromosome in a developing fetus. The subject methods provide for increase accuracy by utilizing information about the mosaicism level of one or more chromosomes of interest in the mother of fetus. ... Natera Inc

06/22/17 / #20170175187

System and method for cleaning noisy genetic data and determining chromosome copy number

Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary dna, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. ... Natera Inc

06/15/17 / #20170166971

System and method for cleaning noisy genetic data and determining chromosome copy number

Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary dna, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. ... Natera Inc

04/20/17 / #20170107576

Detecting mutations and ploidy in chromosomal segments

The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.. ... Natera Inc

03/16/17 / #20170076038

Methods for non-invasive prenatal ploidy calling

Disclosed herein are methods for determining the copy number of a chromosome in a fetus in the context of non-invasive prenatal diagnosis. In an embodiment, the measured genetic data from a sample of genetic material that contains both fetal dna and maternal dna is analyzed, along with the genetic data from the biological parents of the fetus, and the copy number of the chromosome of interest is determined. ... Natera Inc

02/23/17 / #20170051355

Highly multiplex pcr methods and compositions

The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.. ... Natera Inc

02/02/17 / #20170029893

System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals

A system and method for determining the genetic data for one or a small set of cells, or from fragmentary dna, where a limited quantity of genetic data is available, are disclosed. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related subjects. ... Natera Inc

01/12/17 / #20170011166

Methods for non-invasive prenatal ploidy calling

Disclosed herein are methods for determining the copy number of a chromosome in a fetus in the context of non-invasive prenatal diagnosis. In an embodiment, the measured genetic data from a sample of genetic material that contains both fetal dna and maternal dna is analyzed, along with the genetic data from the biological parents of the fetus, and the copy number of the chromosome of interest is determined. ... Natera Inc








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