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National University Of Singapore patents


Recent patent applications related to National University Of Singapore. National University Of Singapore is listed as an Agent/Assignee. Note: National University Of Singapore may have other listings under different names/spellings. We're not affiliated with National University Of Singapore, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "N" | National University Of Singapore-related inventors


A n-doped electrically conductive polymeric material

There is provided a material comprising a n-doped electrically conductive polymer comprising at least one electron-deficient aromatic moiety, each electron-deficient aromatic moiety having a gas-phase electron affinity (ea) of 1-3 ev; and at least one counter-cation covalently bonded to the polymer or to a further polymer comprised in the material, the polymer being n-doped to a charge density of 0.1-1 electron per electron-deficient aromatic moiety, the polymer being capable of forming a layer having a vacuum workfunction (wf) of 2.5-4.5 ev, and wherein all the counter-cations comprised in the material are immobilised such that any electron in the polymer cannot significantly diffuse or migrate out of the polymer. There is also provided a method of preparing the material.. ... National University Of Singapore

Treatment of fibrosis

Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of interleukin 11 (il-11) is disclosed.. ... National University Of Singapore

Spectroscopic tissue analysis apparatus and methods

An apparatus for spectroscopic tissue analysis is disclosed. The apparatus comprises: a light delivery system configured to direct an excitation signal on to a tissue sample; a light collection system configured to collect a backscattered signal comprising diffuse reflectance photons backscattered by the tissue sample; an imaging device; a spectrometer; an optical adaptor configured to direct a first portion of the backscattered signal to the imaging device and a second portion of the backscattered signal to the spectrometer; and an analysis system configured to apply polar decomposition to spectral image data of the tissue captured by the imaging device and the spectrometer and thereby derive polarization metrics for the tissue sample.. ... National University Of Singapore

Intragastric device for weight management

An intragastric device comprising: an inflation magnet provided within a capsule and configured to move towards a first end of a capsule during activation of the intragastric device by applying a magnetic field externally to a user after swallowing the intragastric device; a first chamber and a second chamber physically separated by a partition having a through hole; a separator connected to the inflation magnet and sealing the through hole before activation of the intragastric device, wherein activation of the intragastric device moves the separator to unseal the through hole to allow a chemical reaction between a first chemical stored in the first chamber and a second chemical stored in the second chamber; a balloon secured to the capsule and collapsed against the capsule before activation of the intragastric device; and an expandable volume configured to expand when the balloon is inflated by a gaseous product of the chemical reaction.. . ... National University Of Singapore

Method and system for dynamically optimized of learning

A method for dynamically optimized course of learning is provided. The method comprises creating a learning environment profile of target leaners of a target course, wherein the learning environment profile comprises one or more sets of data collected from the target leaners and one or more teachers of the target course; establishing a plurality of parameters for optimizing cerebral learning for the target leaners in response to the one or more sets of data; optimizing the course of learning in accordance with the plurality of parameters; presenting the optimized course of learning to one or more of the target learners; measuring the cerebral learning of the one or more target leaners of the optimized course or learning to arrive at an effectiveness feedback (efk) of the plurality of parameters; and refining one or more of the plurality of parameters to dynamically optimize the course of learning when the effectiveness feedback falls below a predetermined threshold. ... National University Of Singapore

Printing drug tablets with fully customizable release profiles for personalized medicine

Provided herein is a method for producing a dosage form that can be customized according to a patient's needs. In particular, the invention relates to dosage forms comprising an erodible polymer and an active pharmaceutical agent, wherein the erodible polymer is designed to have a specified geometric shape. ... National University Of Singapore

Wbp2 as a co-prognostic factor with her2 for stratification of patients for treatment

The present invention provides a method for the prognosis of overall survival, cancer recurrence or response to treatment for a patient suffering from cancer, the method comprising: (a) examining a sample from the patient to determine whether the patient is human epidermal growth factor receptor 2 (her2) positive or negative; and (b) measuring ww domain-binding protein 2 (wbp2) levels in the patient's sample, wherein a result in step (a) and a result in step (b) provides a prognosis of overall survival, cancer recurrence or response to treatment for the patient. The present invention also provides a kit carrying out the method of the present invention.. ... National University Of Singapore

A plant protein and modified clay composite

A polymer composite comprising a clay modified with a coupling agent such as an organosilane; and a plant protein matrix, wherein the coupling agent couples the modified clay to the plant protein polymeric matrix. An antimicrobial agent can also be coupled to the coupling agent. ... National University Of Singapore

A polymer product and preparation therof

The present invention provides a polymer product and a method for preparing the polymer product comprising electrospinning from a dope solution comprising at least one polymer and at least one cross-linking agent to prepare and/or fabricate the polymer product. In certain embodiments, the cross-linking agent comprises at least one catecholamine or at least one polyphenol, wherein the method comprises (i) electrospinning the biocompatible polymer product using a dope solution comprising a polymer and at least one catecholamine or at least one polyphenol and (ii) exposing the polymer product to at least one gaseous alkaline reagent. ... National University Of Singapore

Vascularized tissue, skin or mucosa equivalent

The disclosure relates to a method for the differentiation of stem cells to endothelial cells, vascular smooth muscle cells, fibroblasts and keratinocytes; their use in the production of a organotypic vascularized skin or mucosa model or composition; a method relating thereto; the use of the model or composition in the testing of pharmaceutical and/or cosmetic agents; and including therapeutic and cosmetic skin compositions developed or tested thereby.. . ... National University Of Singapore

Il-11ra antibodies

Il-11ra antibodies are disclosed. Also disclosed are compositions comprising the il-11ra antibodies, and methods using the il-11ra antibodies.. ... National University Of Singapore

Il-11 antibodies

Il-11 antibodies are disclosed. Also disclosed are compositions comprising the il-11 antibodies, and methods using the il-11 antibodies.. ... National University Of Singapore

Blockade of cd7 expression and chimeric antigen receptors for immunotherapy of t-cell malignancies

The present invention provides compositions comprising an anti-cd7 chimeric activating receptor (car) and an anti-cd7 protein expression blocker, and methods of using such compositions in cancer therapy.. . ... National University Of Singapore

Selective anti-cancer compounds

A compound of formula i, wherein the compound of formula i has the structure: wherein r1 to r5, y, l, z and x1 to x7 have meanings given in the description, said compounds having utility in the treatment of hyperproliferative disease.. . ... National University Of Singapore

06/21/18 / #20180172678

Dynamic light scattering nanoplatform for high-throughput drug screening

Methods, systems and nanoprobes for identifying sequence-specific transcription factor dna interactions for drug and/or disease screening are provided. The method includes homogeneously mixing plasmonic metal nanoparticle probes with protein samples as an assay in multi-well plates. ... National University Of Singapore

06/21/18 / #20180171354

Vectors

We disclose dumbbell-shaped vectors adapted for efficient expression in mammalian cells. We also disclose a novel method allowing the efficient synthesis of dumbbell-shaped vectors at low cost for delivery of recombinant dna and rna into host cells; and the use of dumbbell-shaped vectors for transient expression in, for example, primary human cells.. ... National University Of Singapore

06/21/18 / #20180169648

A disposable measurement tip and method for use thereof

A disposable measurement tip for an instrument for measuring at least one parameter of a sample, the measurement tip comprising; a tip body; a filling channel in the tip body for holding the sample to be analyzed and having an opening on one end of the tip body to receive the sample; a population of micro-particles held within the tip body filling channel and which can be mixed with the sample when the sample is received in the filling channel; wherein in use the sample in the tip is illuminated by the instrument and the illumination which impinges on the micro-particles is directed back, by the micro-particles, to the instrument to be detected and to thereby enable the at least one parameter to be determined.. . ... National University Of Singapore

05/31/18 / #20180151802

Interconnect structure and method for on-chip information transfer

An interconnect structure for on-chip information transfer, and a method for on-chip information transfer. The interconnect structure comprises a source configured for electrically generating plasmons; a detector configured for electrically detecting the generated plasmons; and a plasmonic waveguide coupled between the source and the detector.. ... National University Of Singapore

05/31/18 / #20180150640

Policy aware unified file system

A system and method for operating a policy aware unification file system within a computer system that takes into account the security requirements of each file system as each file system is unified into the unified file system. As the application is compatible with existing run time policies of files and directories within each file system that is to be unified, the application supports the enforcement of security policies or requirements of each file and/or directory that has been unified into the unified file system.. ... National University Of Singapore

05/31/18 / #20180148506

Blockade of cd7 expression and chimeric antigen receptors for immunotherapy of t-cell malignancies

The present invention provides compositions comprising an anti-cd7 chimeric activating receptor (car) and an anti-cd7 protein expression blocker, and methods of using such compositions in cancer therapy.. . ... National University Of Singapore

05/24/18 / #20180143185

Chemical fluorescent probes for detecting biofilms

The present invention relates to a family of fluorescent compounds based on the bodipy scaffold, and methods for the preparation of said compounds. The present invention further relates to the use of said compounds for the detection of bacterial biofilms, wherein the bacterial biofilm comprises pseudomonas aeruginosa and the compound specifically binds to a fap protein of pseudomonas aeruginosa, or wherein the compound specifically binds to bacterial cells that contain high levels of cyclic-di-guanosine-monophosphate (c-di-gmp).. ... National University Of Singapore

05/17/18 / #20180135016

Chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease

The invention provides a chimeric receptor comprising nkg2d, dap10 and cd3 zeta. Also disclosed is a composition comprising this chimeric receptor and methods for making and using it to enhance the cytotoxicity and antitumor capacity of nk cells. ... National University Of Singapore

05/17/18 / #20180135015

Chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease

The invention provides a chimeric receptor comprising nkg2d, dap10 and cd3 zeta. Also disclosed is a composition comprising this chimeric receptor and methods for making and using it to enhance the cytotoxicity and antitumor capacity of nk cells. ... National University Of Singapore

05/17/18 / #20180135014

Chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease

The invention provides a chimeric receptor comprising nkg2d, dap10 and cd3 zeta. Also disclosed is a composition comprising this chimeric receptor and methods for making and using it to enhance the cytotoxicity and antitumor capacity of nk cells. ... National University Of Singapore

05/17/18 / #20180135013

Chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease

The invention provides a chimeric receptor comprising nkg2d, dap10 and cd3 zeta. Also disclosed is a composition comprising this chimeric receptor and methods for making and using it to enhance the cytotoxicity and antitumor capacity of nk cells. ... National University Of Singapore

05/17/18 / #20180132509

Nanostructured iron/carbon for scavenging oxygen

The invention is directed to a nanostructured composite material comprising a mixture of at least one metal particle such as iron and a carbon material from biomass such as d-glucose, d-glucosamine hydrochloride or a-cyclodextrin. The invention is also directed to a composition comprising the composite material comprising the composite material and an inorganic salt, and a method for synthesizing the composite material comprising immersing the carbon material into a solution of metal ions, drying the impregnated carbon particle and subjecting the impregnated carbon particle to a carbothermal reduction process. ... National University Of Singapore

05/03/18 / #20180119222

Method for diagnosis and prognosis of chronic heart failure

Present application relates to methods for determining whether a subject has heart failure or is at risk of having heart failure, specifically that of heart failure with reduced left ventricular ejection fraction (hfref) and a heart failure with preserved left ventricular ejection fraction (hfpef), comprising determining the level of selected mirna(s) observed in a sample obtained from the subject and wherein an altered level of the mirna(s) compared to control indicates that the subject has heart failure or is at risk of developing heart failure. Also encompassed are methods of determining an altered risk of death or disease progression to hospitalization and death based on alteration of selected mirnas in a sample from the subject and kits thereof.. ... National University Of Singapore

04/19/18 / #20180106873

Method for providing a magnetic sensor with a biasing spin-orbit effective field

The invention relates to magnetic sensor comprising a sensor element that is able to generate a spin-orbit torque (sot). The sot acts as a transverse bias field to set a proper working point for the sensor and so ensure that it responds linearly to an external field with maximized sensitivity. ... National University Of Singapore

04/19/18 / #20180105583

Antibodies that bind zika virus envelope protein and uses thereof

Isolated monoclonal antibodies which bind to zika virus envelope protein and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.. ... National University Of Singapore

04/05/18 / #20180096069

Interactive clothes searching in online stores

A clothing search system provides a clothing search to users using a component-based image search. Retailer catalogs are analyzed to determine clothing components within clothing images. ... National University Of Singapore

03/22/18 / #20180080035

Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway

The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (ggpps) enzyme in cells and the production of terpenoids.. . ... National University Of Singapore

03/08/18 / #20180067000

A resistive microfluidic pressure sensor

A resistive microfluidic pressure sensor is provided which comprises a first layer comprising a microfluidic channel with a carbon-based conductive liquid and a second layer comprising at least two electrodes, the at least two electrodes being adapted to measure resistance of the carbon-based conductive liquid upon deformation of the microfluidic channel as a result of a change in force applied on a surface of the sensor.. . ... National University Of Singapore

03/08/18 / #20180064074

Chimeric gene constructs for generation of fluorescent transgenic ornamental fish

Four zebrafish gene promoters, which are skin specific, muscle specific, skeletal muscle specific and ubiquitously expressed respectively, were isolated and ligated to the 5′ end of the egfp gene. When the resulting chimeric gene constructs were introduced into zebrafish, the transgenic zebrafish emit green fluorescence under a blue light or ultraviolet light according to the specificity of the promoters used. ... National University Of Singapore

02/22/18 / #20180051107

Construct for promoting absorption of molecules by a cell and methods of using the contstruct

The present disclosure is directed to a construct for promoting absorption of molecules by a cell and the application thereof in drug and gene delivery. The present disclosure further describes topographical modulation of endocytosis for drug and gene delivery.. ... National University Of Singapore

02/08/18 / #20180040887

Sodium-ion battery anode

The present invention relates to an electrode material for a sodium-ion battery, in particular, the present invention relates to an electrode material suitable for use as an anode of a sodium-ion battery wherein the electrode material comprises sodium titanate. In an aspect of the present invention, the electrode material comprises a sodium titanate having the formula na3+xti3o7, wherein the value of x is defined as −0.5≦x≦0.3, wherein said material is an intermediate phase between na2ti3o7 and na3+xti3o7.. ... National University Of Singapore

02/01/18 / #20180033956

High efficiency spin torque switching using a ferrimagnet

In one embodiment, a spin torque device uses a thick (e.g., >1 nm, and preferably >=2-6 nm) ferrimagnet (fim) layer, instead of a thin (e.g., <1-2 nm) fm layer in the device's stack. The fim layer may be composed of a cobalt-gadolinium (co—gd) alloy, cobalt-terbium (co—tb) multilayers, or other materials that provide anti-ferromagnetic coupling between two sub-lattices. ... National University Of Singapore

01/25/18 / #20180026215

Organic field-effect-transistors with low contact resistance

This invention provides a transistor device structure that in-corporates a self-aligned doped contact formed by inserting a molecularly-thin layer of bonded anions between the semiconductor and the source-drain electrode array wherein the semiconductor is p-doped at the interface with the bonded-anion layer, and a method of making this structure using oxidant species incorporated into the molecularly-thin layer. The device shows ohmic hole injection and hole extraction at the contacts to give high-performance transistor characteristics with low contact resistance.. ... National University Of Singapore

01/18/18 / #20180017551

Process for making an array

There is disclosed a method of making an array for cell assays comprising the step of providing an array of structures on a substrate, each of said structures having a pre-defined topography thereon, and wherein at least one structure has a different topography from at least one other structure.. . ... National University Of Singapore

01/18/18 / #20180016618

Electrochemical detection of microorganisms

The present invention provides a method for determining the presence of a microorganism in a sample using an electrochemically active reporter, wherein the method comprises (a) contacting the sample with an electrochemically active reporter, wherein the electrochemically active reporter is a conjugate comprising a sugar moiety and a redox active reporter moiety that are covalently linked such that the covalent bond can be enzymatically cleaved in the presence of the microorganism by an enzyme expressed by the microorganism, wherein the redox active reporter moiety is selected from the group consisting of resorufin and compounds of formula (i) as defined herein, under conditions that allow enzymatic cleavage of the covalent bond between the sugar moiety and the redox active reporter moiety and reduction of the redox active report moiety in the presence of the microorganism; (b) electrochemically determining the released redox active reporter moiety; and (c) determining the presence of the microorganism and, optionally, number of the microorganisms in the sample based on the determined released redox active reporter moiety. Also encompassed are the electrochemically active reporters used in the described methods and their use for determination of the presence of microorganisms in a sample.. ... National University Of Singapore

01/11/18 / #20180009952

Fillers for polymers

This invention relates to a composite material comprising a core comprising an organosilica such as a polyhedral oligomeric silsesquioxane (poss) and a functionalized elastomeric polymer such as poly(n-butyl acrylate) bonded onto said core. The elastomer is preferably functionalised with an amine moiety. ... National University Of Singapore

01/11/18 / #20180008638

Methods for enhancing efficacy of therapeutic immune cells

The present invention relates to a method of using a receptor (e.g., chimeric antigen receptor—car) that activates an immune response upon binding a cancer cell ligand in conjunction with a target-binding molecule that targets a protein or molecule ci for removal or neutralization to generate enhanced anti-cancer immune cells. The present invention also relates to engineered immune cells having enhanced therapeutic efficacy and uses thereof.. ... National University Of Singapore

01/04/18 / #20180000638

Convex contact probe for the delivery of laser energy

Systems, devices, and methods for treating a glaucomatous eye are provided. Embodiments may provide a treatment probe for treating an eye of a patient. ... National University Of Singapore

12/07/17 / #20170351612

Data processing method and device in cache coherence directory architecture

The embodiment of the disclosure discloses a data processing method and device in a cache coherence directory architecture. The method includes that allocating a tag entry in a tag array for a data block; allocating a data entry in a data array for the data block when the data block is actively shared; and de-allocating the data entry when the data block is temporarily private or gets evicted in the data array. ... National University Of Singapore

12/07/17 / #20170349546

Light-activated two-component protein binding matrix

A binding pair for chromatographic separation or purification of a molecule of interest, where one binding member of the pair is an isomerizable organic molecule and the other binding member of the pair is an isomer-specific affinity agent bound to a molecule of interest. The binding pair associates and disassociates upon exposure to a binding agent, such as using light, decreased intensity of light, darkness, heat, stress, ions, an isomerizable affinity agent, change in ph, or a combination thereof.. ... National University Of Singapore

12/07/17 / #20170347878

A method and system for monitoring and/or assessing pupillary responses

The present invention relates to a method for monitoring and/or assessing pupillary responses to a continuous illumination of light starting at a first intensity which is gradually changed to subsequent intensity over a predefined period of time. The method may be used to detect aberrant pupillary responses. ... National University Of Singapore

10/26/17 / #20170306001

Chimerization and characterization of a monoclonal antibody with potent neutralizing activity across multiple influenza a h5n1 clades

Mab 9f4 provides heterologous protection against multiple influenza a h5n1 clade viruses, including one of the recently designated subclades, namely 2.3.4, through binding to a novel epitope. The present invention relates to isolated mouse-human chimeric (xi) igg1-9f4 and iga1-9f4 mab which retain high degrees of binding and neutralizing activity against influenza h5n1. ... National University Of Singapore

10/12/17 / #20170292104

Microfluidic system and method for perfusion bioreactor cell retention

A microfluidic system for cell retention for a perfusion bioreactor is provided. The system comprises at least one inlet configured to receive a bioreaction mixture to be processed. ... National University Of Singapore

10/05/17 / #20170283721

Catalytic membrane system for converting biomass to hydrogen

A two-reactor catalytic system including a catalytic membrane gasification reactor and a catalytic membrane water gas shift reactor. The catalytic system, for converting biomass to hydrogen gas, features a novel gasification reactor containing both hollow fiber membranes that selectively allow o2 to permeate therethrough and a catalyst that facilitates tar reformation. ... National University Of Singapore

09/28/17 / #20170280523

Single-stage multi-string led driver with dimming

A driver circuit for light emitting diodes (leds) and a driving method for leds. The driver circuit comprises a single stage dc-dc converter with multiple output channels, the converter comprising one set of switches on a primary side of the converter, a rectifier and voltage multiplier component at the secondary side; and a dimming control component configured to control the respective switches on the primary side of the converter for controlling an output current in the multiple output channels.. ... National University Of Singapore

09/28/17 / #20170279038

Magnetization-switching magnetic system

A magnetic system containing a plurality of stacked layer arrays, each of which includes a first anti-ferromagnetic (afm1) layer, a heavy metal (hm) layer formed of a material having strong spin-orbit coupling, and, optionally, a ferromagnetic (fm) layer or a second anti-ferromagnetic (afm2) layer. Also disclosed is a method of preparing such a magnetic system.. ... National University Of Singapore

09/21/17 / #20170270986

Techniques to improve switching probability and switching speed in sot devices

In one embodiment, a desirable (e.g., substantially 100%) sot switching probability is achieved in a sot device by applying in-plane input current as one or more pulses having a tuned pulse width. In the case of a single pulse, pulse width may be selected as a single tuned pulse width or a range of pulse widths that avoid a specific pulse width determined to cause a switch-back response. ... National University Of Singapore

09/21/17 / #20170266224

Cationic polyamines for treatment of viruses

Antiviral cationic polyamines were prepared by modifying polyethylenimines with n-acylating agents that introduce a side chain comprising one or more carbons and at least one alcohol hydroxy group. The cationic polyamines can have a linear or branched polyethylenimine backbone structure. ... National University Of Singapore

09/14/17 / #20170263447

Method to transfer two dimensional film grown on metal-coated wafer to the wafer itself in a face-to-face manner

A method of in-situ transfer during fabrication of a component comprising a 2-dimensional crystalline thin film on a substrate is disclosed. In one embodiment, the method includes forming a layered structure comprising a polymer, a 2-dimensional crystalline thin film, a metal catalyst, and a substrate. ... National University Of Singapore

09/07/17 / #20170254952

Highly efficent on-chip direct electronic-plasmonic transducers

In one embodiment, an on-chip electronic-plasmonic transducer is provided that is capable of both direct plasmon generation and detection at high efficiencies. The electronic-plasmonic transducer includes a metal-insulator-metal junction formed from a first wire constructed of a first metal, a tunneling barrier material in contact with the first wire, and a second wire made from a second metal in contact with the tunneling barrier material. ... National University Of Singapore

08/24/17 / #20170242840

Methods and systems for automated text correction

The present embodiments demonstrate systems and methods for automated text correction. In certain embodiments, the methods and systems may be implemented through analysis according to a single text correction model. ... National University Of Singapore

08/24/17 / #20170238876

Multi-channel neural signal amplifier system providing high cmrr across an extended frequency range

A high cmrr neural signal amplifier is configured for supply rail common mode feedback (sr-cmfb) whereby a set of cmfb signals is provided to supply rails of front end lnas. High cmrr is maintained through buffering outputs of front end signal lnas and a reference lna coupled to signal and reference inputs of second stage amplifiers, respectively; and buffering the reference lna output using an active/guard buffer pair, whereby across a plurality of distinct multiplexing time intervals, during each multiplexing time interval one buffer of the pair functions as an active buffer that drives second stage amplifier reference inputs corresponding to second stage amplifier outputs being multiplexed to a set of multiplexor outputs, and the other buffer of the pair functions as a guard buffer coupled to other second stage amplifier reference inputs corresponding to second stage amplifier outputs not being multiplexed to the set of multiplexor outputs.. ... National University Of Singapore

08/17/17 / #20170237106

A battery system

The present invention relates to batteries and more particularly to battery systems. More particularly, the present invention relates to metal-air based battery systems. ... National University Of Singapore

08/17/17 / #20170237002

Resistive switching co-sputtered pt-(nio-al2o3)-pt devices

In one embodiment, a capacitor-like structure is constructed that includes an rf co-sputtered tmo layer. The capacitor-like structure includes a first electrode (e.g., a bottom electrode) constructed of a first metal (e.g., pt), a rf co-sputtered tmo layer on the first electrode including a first oxide and a second oxide (e.g., a rf co-sputtered al2o3—nio layer), and a second electrode constructed of a second metal (e.g., pt) in contact with the co-sputtered tmo layer. ... National University Of Singapore

08/17/17 / #20170231529

Method and apparatus for assisting movement rehabilitation

A method and apparatus implementing a tele-rehabilitation system with remote supervision via wireless telecommunication means is disclosed. The method for assisting a user performing musculoskeletal movement in rehabilitation exercise comprises of motion-sensing a first part of user's body to be exercised (e.g. ... National University Of Singapore

08/10/17 / #20170226541

Method of improving solvent tolerance in microbes

The invention relates generally to a method of improving solvent tolerance in microbes, and in particular, to a method of improving bio-butanol titre in a fermentation process due to improved solvent tolerance in microbes. The method of improving butanol titre in a fermentation process involves the addition of a membrane insertion molecule comprising a conjugated oligoelectrolyte, particularly an oligo-polyphenylene vinylene conjugated oligoelectrolyte.. ... National University Of Singapore

08/10/17 / #20170226511

Aptamers for binding flavivirus proteins

The present invention relates to nucleic acids. In particular, it relates to aptamers capable of binding to a flavivirus structural protein or a flavivirus non-structural protein, useful as therapeutics for preventing, treating and/or diagnosing a flavivirus infection in a patient.. ... National University Of Singapore

08/03/17 / #20170222146

Multilayer heterostructures for application in oleds and photovoltaic devices

This invention relates to a supported polymer heterostructure and methods of manufacture. The heterostructure is suitable for use in a range of applications which require semiconductor devices, including photovoltaic devices and light-emitting diodes.. ... National University Of Singapore

08/03/17 / #20170219581

Methods and compositions for modulating th-gm cell function

Disclosed herein is a t-helper cell (“th-gm” cell) that is regulated by il-7/stat5 and which secrete gm-csf/il-3. Also disclosed are methods and compositions for modulating th-gm function for the treatment of, e.g., inflammatory disorders. ... National University Of Singapore

07/27/17 / #20170210840

Thermogelling graft copolymer and method of preparation thereof

A thermogelling graft copolymer is provided. The copolymer is obtainable by (a) polymerizing, in a first step, an activated lignin-based polymer with n-isopropylacrylamide (nipaam) to form a lignin/poly(n-isopropylacrylamide) (pnipaam) graft copolymer, and (b) polymerizing, in a second step, the lignin/poly(n-isopropylacrylamide) (pnipaam) graft copolymer with a monomer mixture comprising (i) poly(ethylene glycol) (meth)acrylate and/or a c1-10 alkyl ether thereof, and (ii) poly(propylene glycol) (meth)acrylate and/or a c1-10 alkyl ether thereof, to obtain a lignin-poly(n-isopropylacrylamide)-block-poly(ethylene glycol)/poly(propylene glycol) graft copolymer. ... National University Of Singapore

07/20/17 / #20170203340

Rapid cleaning method for ultrapure water piping system

A cleaning method including an alkaline cleaning step followed by an acid cleaning step is used, for example, to treat a newly constructed ultrapure water distribution piping system (using pvdf piping system). The inherent inorganic and organic contaminants in the piping material as well as contaminants deposited (if any) during the construction phase can be removed efficiently. ... National University Of Singapore

07/13/17 / #20170200851

Device incorporating an oxide film and method of fabricating the same

A device and a method of forming a device. The method comprises forming an oxide material film; forming two metal electrodes on the oxide material film, the two metal electrodes laterally spaced from each other such that an electric path between the two electrodes comprises at least a portion of the oxide material film; configuring the oxide material film such that a current-voltage characteristic of the device as measured via the two metal electrodes exhibits nonlinearity and rectification.. ... National University Of Singapore

07/13/17 / #20170200486

Techniques to modulate spin orbit spin transfer torques for magnetization manipulation

In one embodiment, a so-stt device has a non-symmetric device geometry. The device may be fabricated to have a non-symmetric magnetic pattern by tilting a shaped magnetic pattern (e.g., an ellipse, diamond, rectangle, etc. ... National University Of Singapore

07/06/17 / #20170191765

Device and method for a two phase heat transfer

The invention provides a two phase heat transfer device comprising an inlet for receiving a heat transfer fluid, and; an array of heat transfer fins in spaced relation; primary spaces between said heat transfer fins defining primary channels parallel to a path from the inlet to outlet, and; oblique spaces between said heat transfer fins defining oblique channels arranged at an angle to said primary channels. It is preferable that walls defining the primary and oblique spaces provide nucleate boiling regions and the interruption of fully developed convective boiling regions.. ... National University Of Singapore

06/29/17 / #20170186457

Graphene as a protective overcoat for magnetic media without the use of a nucleation layer

A graphene layer, used as an anti-corrosive protection medium for magnetic media, overcomes the existing problem of reducing the carbon overcoat layer thickness for magnetic media. Unlike the amorphous carbon that is currently used as an anti-corrosion layer, the impenetrability of graphene to all known gaseous substances enables full corrosion protection of the underlying magnetic medium with a layer of graphene that may be, for example, as thin as a single layer of graphene. ... National University Of Singapore

06/22/17 / #20170179561

Reconfigurable waveguide for spin wave transmission

A waveguide for spin wave (sw) transmission, a method of fabricating a waveguide for sw transmission, and a method of transmitting an sw. The waveguide comprises a plurality of nanomagnetic material elements, each nanomagnetic material element having a respective predetermined geometric shape such that each nanomagnetic material element exhibits a deterministic ground state initializable by a magnetic field applied across the waveguide; wherein the nanomagnetic material elements are disposed relative to each other for dipolar coupling between adjacent nanomagnetic material elements.. ... National University Of Singapore

06/22/17 / #20170177563

Methods and systems for automated text correction

The present embodiments demonstrate systems and methods for automated text correction. In certain embodiments, the methods and systems may be implemented through analysis according to a single text correction model. ... National University Of Singapore

06/22/17 / #20170174812

Crosslinked polymers prepared from functional monomers having imidazolium, pyridinium, aryl-substituted urea or aryl-substituted thiourea groups and uses thereof

The invention relates to a polymer obtainable by radical co-polymerisation of a first monomer of general formula (i) or (ii) or a mixture thereof: wherein a, a′, b, b′ x, y, y′ and n are as defined herein; with a second, cross-linking monomer and optionally with one or more further co-monomers; wherein the molar ratio of the first monomer to other monomers is less than or equal to 1:5. The polymers selectively bind to phosphate ester compounds and can be used as a solid phase in a method for isolating compounds comprising a phosphate ester group from a mixture comprising one or more phosphate monoesters and/or phosphate diesters and/or other compounds such as lipids.. ... National University Of Singapore

06/22/17 / #20170174759

Treatment of fibrosis

Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of interleukin 11 (il-11) is disclosed.. ... National University Of Singapore

06/22/17 / #20170174732

Nanobody-flourescent protein fusion

We describe the rational structure-based design of monomeric and dimeric forms of a nanobody-enhanced gfp (termed vsfgfp) that demonstrates ˜1.3-fold higher brightness than sfgfp in a monomeric form and ˜2.5-fold higher brightness in a dimeric form. These new vsfgfp variants demonstrate high stability and brightness in both bacterial and eukaryotic cells and are thus ideal for in vivo imaging applications. ... National University Of Singapore

06/22/17 / #20170173083

Compositions and methods for ex vivo expansion of human hematopoietic stem/progenitor cells

Described herein are methods and compositions which lead to the efficient ex vivo expansion of hematopoietic cells, such as hematopoietic stem cells (hscs) and hematopoietic stem and progenitor cells hspcs. Using combinations of small molecule drugs and cytokines/growth factors/grown factors targeting epigenetic status in cells, significant improvements in the expansion of cells was observed, including cells isolated from human cord blood or peripheral mobilized stem/progenitor cells. ... National University Of Singapore

06/15/17 / #20170168073

Chalcone-urea derivatives as insulin sensors

The invention relates to compounds of formula (i) or derivatives, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites or prodrugs thereof, in which the substituents are as defined in the specification. These compounds may be useful as insulin sensors; in insulin secretion studies and as probes for insulin detection.. ... National University Of Singapore

06/15/17 / #20170166867

2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis

This invention relates to a method for inducing or enhancing the differentiation of pluripotent stem cells into cardiomyocyte via casein kinase 1 inhibition said method comprising culturing the stem cells in the presence of a medium comprising a casein kinase 1 inhibitor of the formula (i) or (ii) or a stereoisomer, tautomer, or a salt thereof wherein r1, r2 and r3 independently from another represent hydrogen, optionally substituted alkyl, alkenyl, alkynyl, heterocyclyl, heteroaryl or aryl; x represents nr4, o or s; and r4 represents hydrogen, optionally substituted alkyl, alkenyl, alkynyl, heterocyclyl, heteroaryl or aryl. The method can be used in the late phase of stem cell differentiation and in the compounds of formula (i) or (ii) in combination with other small molecules can lead to especially high differentiation of stem cells into cardiomyocytes. ... National University Of Singapore

06/15/17 / #20170164869

Systems and methods for tracking and displaying endoscope shape and distal end orientation

Systems and methods for tracking shape and orientation of an endoscope employ motion tracking sensors to track locations on the endoscope for use in determining real time shape and distal end orientation for display during navigation of the endoscope. An example system includes sensor units distributed along the endoscope and a control unit. ... National University Of Singapore

06/08/17 / #20170158742

Biotinylated protein

Disclosed are methods of screening a library of molecules to identify or select one or more molecules which selectively bind to a fused protein, or fragment thereof. The fused protein comprises a moiety and a protein selected from a group consisting of flavivirus structural and non-structural (ns) proteins. ... National University Of Singapore

05/18/17 / #20170139495

Human-machine interface with graphene-pyroelectric materials

A version of the invention comprises a device for controlling or interfacing with a computer or other form of communicable machine based on the pyroelectric effect, and includes at least one optically- and infrared- (ir-) transparent graphene electrode.. . ... National University Of Singapore

05/18/17 / #20170138860

Raman spectroscopy system, apparatus, and method for analyzing, characterizing, and/or diagnosing a type or nature of a sample or a tissue such as an abnormal growth

Characterizing, identifying, or diagnosing the type and/or nature of a sample or a tissue such as an abnormal growth using a raman spectrum includes analyzing distinct spectral subintervals within the raman spectrum in two distinct wavelength ranges, such as fp and hw wavelength ranges, to identify a match with one or more reference markers in one or both wavelength ranges; and from the match characterizing, identifying, or diagnosing the type and/or nature of the sample or tissue. Fp and hw raman spectra can be detected or acquired simultaneously using a single diffraction grating.. ... National University Of Singapore

05/04/17 / #20170121720

Combinatorial metabolic engineering of saccharomyces cerevisiae for terminal alkene production

Modified saccharomyces cerevisiae yeast that produce terminal alkenes are described. The modification of the saccharomyces cerevisiae yeast includes insertion of at least one heterologous fatty acid decarboxylase gene, deletion of faa1 and faa4, overexpression of hem3, and triple-deletion of ctt1, cta1 and ccp1. ... National University Of Singapore

05/04/17 / #20170121271

Multiphase reactor system

A one-to-many parallelized millireactor system capable of high throughput production in millireactors. Also disclosed is a method for carrying out multi-phase reactions.. ... National University Of Singapore

05/04/17 / #20170119614

Actuator device, method and system for limb rehabilitation

An actuator device, a method and a system for limb rehabilitation, and a pneumatic actuator element. The actuator device for limb rehabilitation comprises one or more pneumatic actuator elements; and means for coupling the pneumatic actuator elements to the limb at or near one or more joints of the limb; wherein each pneumatic actuator element comprises: an expandable main body having a longitudinal axis; one or more channel networks formed in the main body such that, in an acquiescent state of the pneumatic actuator element, a projected length of each channel network along the longitudinal axis is shorter than a total channel length of said each channel network.. ... National University Of Singapore

04/20/17 / #20170107491

Chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease

The invention provides a chimeric receptor comprising nkg2d, dap10 and cd3 zeta. Also disclosed is a composition comprising this chimeric receptor and methods for making and using it to enhance the cytotoxicity and antitumor capacity of nk cells. ... National University Of Singapore

04/20/17 / #20170106074

Influenza vaccine, composition, and methods of use

The invention relates to compositions and vaccines that include a mutated bordetella strain for treating or preventing an influenza infection in a mammal. In addition, the invention further provides methods for protecting a mammal against infection by influenza and/or eliciting an immune response against an influenza virus in a mammal using the composition or vaccine.. ... National University Of Singapore

04/13/17 / #20170102473

Wing for wide tow of geophysical survey sources

Techniques are disclosed relating to wide towing of marine survey signal sources. In one embodiment, an apparatus includes a signal source and a wing coupled to the signal source. ... National University Of Singapore

04/13/17 / #20170101358

Triphasic flow millireactors

Disclosed is a reactor system that contains multiple millireactors, each including a millitube, a first feed line, a second feed line, and a third feed line. Each of the first and second feed lines has a hydraulic damper disposed therein. ... National University Of Singapore

03/23/17 / #20170081723

Fusion genes in cancer

The present invention relates to a method for determining or making of a prognosis if a patient has cancer or is at an increased risk of having cancer, the method comprising testing for the presence of one or more cancer-associated fusion genes, or proteins derived thereof, in a sample obtained from a patient. More specifically, the present invention relates to fusion genes clec16a-emp2, snx2-prdm6, mll3-prkag2, dus2l-pskh1 and cldn18-arhgap26 in gastric cancer. ... National University Of Singapore

03/09/17 / #20170067919

Compositions and methods utilizing lysophosphatidylcholine scaffolds

The invention relates to compositions and methods for utilizing lysophosphatidylcholine scaffolds. The compositions and methods can be used for lpc-mediated delivery of fatty acids and other molecules; to screen and identify fatty acid formulations for parenteral nutrition; and for live animal organ imaging, among other uses. ... National University Of Singapore

03/09/17 / #20170067084

Production of chiral 1,2-amino alcohols and alpha-amino acids from alkenes by cascade biocatalysis

Disclosed herein are methods of forming chiral 1,2-aminoalcohols and α-aminoacids from alkene starting materials by way of an enzymatic cascade reaction sequence that may be accomplished in a single reaction vessel without the need to isolate any intermediates. Also disclosed herein are recombinant nucleic acids, vectors and host cells for use in the methods of the invention.. ... National University Of Singapore

02/23/17 / #20170049997

Arterial sheath which allows distal perfusion within a cannulated vessel

Defining proximal as toward the heart and distal as away from the heart, a sheath includes a proximal opening and multiple fenestrations maintainable in position slightly beyond a site or point of sheath entry into a vessel by way of an anchoring assembly having a set of radially displaceable anchoring elements configured for abutting a superficial vessel wall. The fenestrations and/or anchoring element(s) are arranged obliquely or non-obliquely around peripheral portions of the sheath. ... National University Of Singapore

02/16/17 / #20170045520

Method for predicting response to therapy for cancer

The present invention provides a method of predicting response of a cancer patient to a therapy. The method comprises the step of determining a presence or absence of at least one mutation of itch (seq id no: 1) in a first sample isolated from a cancer patient, wherein the presence of a mutation is predictive of response of the cancer patient to a therapy selected from the group consisting of: wnt pathway-, egfr-, her2-, hormonal- and wbp2-based therapy.. ... National University Of Singapore

02/16/17 / #20170045397

Device for analysing a specimen and corresponding method

A device for analysing a specimen is disclosed. The device comprises a first polarizer for polarizing a first beam of electromagnetic radiation; an optical device for directing the polarized beam of electromagnetic radiation at the specimen to enable interaction between the polarized beam of electromagnetic radiation and the specimen to cause generation of a second beam of electromagnetic radiation; a plurality of second polarizers for dividing the wavefront of the second beam of electromagnetic radiation into a plurality of beams of electromagnetic radiation polarized with different polarization states; and at least one spectrometer for analysing respective electromagnetic spectrums of the plurality of polarized beams of electromagnetic radiation to enable the specimen to be characterised. ... National University Of Singapore

02/16/17 / #20170044479

Dispase-based junctional protein tensor dish

Cell-culture devices and methods for determining the integrity of cell-cell adhesion are described. A cell culture device includes a channel-defining body that defines a plurality of channels in a cell-culture dish and a removable mask located above the channel-defining body. ... National University Of Singapore

02/16/17 / #20170042439

System, device and methods for brainwave-based technologies

System, device and methods for brainwave-based technologies. The system for measuring and processing brainwave data of a user comprises one or more electrodes for measuring the brainwave data of the user, and a processing unit coupled to the electrodes and configured to process the brainwave data for determining a current mental state of the user and to generate, based on the current mental state of the user, a control signal for instructing activation of a means for manipulating the current mental state of the user.. ... National University Of Singapore

02/09/17 / #20170038371

Combinatoric encoding methods for microarrays

A method for determining a presence or absence of one or more target analytes in a sample includes contacting the sample with an array of particles comprising at least first and second particle subsets disposed therein with a known particle number ratio with respect to each other. The first particle subset has at least one binding site configured to bind with a first target analyte and the second particle subset has at least one binding site configured to bind with a second, different target analyte. ... National University Of Singapore

02/02/17 / #20170033800

Symmetrical capacitor arrays succesive approximation register (sar) analog-to-digital converter (adc)

Analog-to-digital converter (adc) circuitry includes a first binary-weighted capacitor array having a total capacitance of 2n-2c. The value of n represents number of bits of a digital signal that represents an analog signal. ... National University Of Singapore

02/02/17 / #20170032815

Method of protecting a magnetic layer of a magnetic recording medium

A method of protecting a magnetic layer of a magnetic recording medium is provided to reduce the thickness of the magnetic spacing while improving corrosion resistance and tribological performance of the magnetic recording medium.. . ... National University Of Singapore

01/19/17 / #20170016770

Optical interference device

An optical interference device 100 is disclosed herein. In a described embodiment, the optical interference device 100 comprises a phase shifter array 108 for receiving a collimated beam of light. ... National University Of Singapore

01/19/17 / #20170014776

Anti-fouling membranes

A membrane assembly is provided. The membrane assembly comprises a membrane having a first surface and an opposing second surface, and a layer of anti-fouling polymer selected from the group consisting of an optionally functionalized hyperbranched polyglycerol, a hyperbranched polyimine, a zwitterionic copolymer obtainable by polymerizing 2-methacryloyloxyethyl lipoate with at least one of [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium hydroxide or 2-methacryloyloxyethylphosphorylcholine, and combinations thereof arranged on the first surface of the membrane. ... National University Of Singapore

01/12/17 / #20170009208

Biophysically sorted osteoprogenitors from culture expanded bone marrow derived mesenchymal stromal cells (mscs)

The invention provides, inter alia, populations of large mesenchymal stem cells (msc)(as well as conditioned medium from these cells) with enhanced regenerative potential, as well as methods of culturing and using these populations, such as therapeutic methods of mediating tissue repair or enhancing homing and engraftment of hematopoietic stem cells. These large msc populations can, in certain embodiments, be produced by biophysically sorting an msc-containing population.. ... National University Of Singapore

01/12/17 / #20170007800

Arterial cannula which allows proximal and distal perfusion within a cannulated vessel

A cannula includes a first segment configured to reside entirely within a vessel. The first segment includes a proximal exit opening disposed nearer to the heart, and multiple fenestrations disposed distally away from the proximal exit opening near a cannulation site. ... National University Of Singapore

01/05/17 / #20170005663

Nanomagnetic network structures and a method of reconfigurable operation based on magnetization dynamics

A nanomagnetic structure and a method of fabricating a nanomagnetic structure. The nanomagnetic comprises two or more nanomagnetic material elements, each nanomagnetic material element having a respective predetermined geometric shape such that the nanomagnetic structure exhibits different stable ground states initializable by magnetic fields applied across the nanomagnetic structure in respective different directions; wherein the nanomagnetic material elements are disposed relative to each other such that the magnetic structure exhibits a difference in effective internal magnetic field strength between the different stable ground states. ... National University Of Singapore

01/05/17 / #20170002382

Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway

The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.. . ... National University Of Singapore

01/05/17 / #20170002366

Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway

The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (ggpps) enzyme in cells and the production of terpenoids.. . ... National University Of Singapore

01/05/17 / #20170000908

A micellar particle

There is provided a micellar particle having at least a core-shell configuration, wherein a fluorescent molecule is encapsulated within said core and wherein said shell is formed from an inorganic compound.. . ... National University Of Singapore

01/05/17 / #20170000887

Uniform core-shell tio2 coated upconversion nanoparticles and use thereof

An upconversion nanoparticle (ucn) coated with a layer of semiconductor material is disclosed. The ucn core acts as a nanotransducer to convert near infrared (nir) to visible and/or ultraviolet (uv) light while the semiconductor shell serves as a photocatalyst. ... National University Of Singapore

01/05/17 / #20170000850

Differentiation therapy with cd137 ligand agonists

There is disclosed a method of treating cancer comprising administering an agonist of cd137 ligand (cd137l) to a subject in need thereof.. . ... National University Of Singapore








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