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Northwestern University patents


Recent patent applications related to Northwestern University. Northwestern University is listed as an Agent/Assignee. Note: Northwestern University may have other listings under different names/spellings. We're not affiliated with Northwestern University, we're just tracking patents.

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Devices for material delivery, electroporation, sonoporation, and/or monitoring electrophysiological activity

The invention relates generally to systems and devices for material delivery, energy delivery, and/or monitoring electrophysiological activity, and method of use thereof. In particular, the present invention provides devices and systems, and methods of use thereof, configured to deliver therapeutic compositions, to provide electroporation and/or sonoporation to increase therapeutic efficiency, and to monitor electrophysiological activity, for example, before and after treatment.. ... Northwestern University

Nanoconjugates able to cross the blood-brain barrier

Polyvalent nanoconjugates address the critical challenges in therapeutic use. The single-entity, targeted therapeutic is able to cross the blood-brain barrier (bbb) and is thus effective in the treatment of central nervous system (cns) disorders. ... Northwestern University

System and method for electrical characterization of electrical materials

Systems and methods can provide a fast and accurate way to measure conductivity and hall effect, such that transient conductivities, transient carrier densities or transient mobilities can be measured on millisecond time scales, for example. The systems and methods can also reduce the minimum magnetic field needed to extract carrier density or mobility of a given sample, and reduce the minimum mobility that can be measured with a given magnetic field.. ... Northwestern University

Nucleic acid functionalized nanoparticles for therapeutic applications

Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided.. . ... Northwestern University

Photocrosslinking reagents and methods of use thereof

Provided herein are photocrosslinking reagents, crosslinkable proteins displaying photocrosslinking groups, crosslinked protein-protein complexes, and methods of use thereof.. . ... Northwestern University

Annuloplasty ring for receiving a replacement valve

An annuloplasty ring including elastic features that make the ring optimal for receiving a subsequent prosthetic valve via a “valve in ring procedure.” the elastic features provide a squeezing force on the native valve annulus that both ensures coaptation of the native valve leaflets and also prevents paravalvular leakage around a subsequently-placed prosthetic valve.. . ... Northwestern University

Chalco-phosphate-based hard radiation detectors

Methods and devices for detecting incident radiation, such as incident x-rays or gamma-rays, are provided. The methods and devices use high purity, high quality single-crystals of inorganic semiconductor compounds having the formula a2p2x6, where a represents pb or sn and x represents s or se, as photoelectric materials.. ... Northwestern University

Carbonaceous nanoparticles, methods of making same and uses thereof

Compositions of carbonaceous nanoparticle fabrication and their use for electrode materials in supercapacitors are provided. The supercapacitor includes a first electrode having a first substrate and carbonaceous nanoparticles; a second electrode comprising a second substrate and carbonaceous nanoparticles; a separator positioned between the first electrode and the second electrode; and an electrolyte. ... Northwestern University

Cxcr4 chemokine receptor modulators

Provided herein are small molecule modulators of cxcr4 activity (e.g., agonists, antagonists, inverse agonists, partial agonists), and methods of use thereof (e.g., for the treatment of disease).. . ... Northwestern University

Compositions and methods for urinary bladder regeneration

The present invention provides compositions and methods for the regeneration of tissue. In particular, the present invention provides mesenchymal stem cells (mscs) and endothelial progenitor cells (epcs) for bladder regeneration.. ... Northwestern University

Injectable thermoresponsive polyelectrolytes

Provided herein are compositions, devices, and systems comprising thermoresponsive, biodegradable elastomeric materials, and methods of use and manufacture thereof.. . ... Northwestern University

Nylon-3 co-polymers and synthetic lung surfactant compositions containing same

Non-natural oligomers have recently shown promise as functional analogues of lung surfactant proteins b and c (sp-b and sp-c), two helical and amphiphilic proteins that are critical for normal respiration. The generation of non-natural mimics of sp-b and sp-c has previously been restricted to step-by-step, sequence-specific synthesis, which results in discrete oligomers that are intended to manifest specific structural attributes. ... Northwestern University

Inhibition of cancer cell motility

Provided herein are compositions and methods for inhibiting cancer cell motility and/or metastasis. In particular embodiments, kbu2046 (or an analog thereof) and one or more additional therapies (e.g., cancer therapies (e.g., hormone therapies and chemotherapies) are provided to inhibit cancer cell motility, inhibit metastasis, and/or treat cancer (e.g., prostate cancer, lung cancer, breast cancer, colon cancer, etc.).. ... Northwestern University

Compositions and methods to reduce pharmaceutical-induced toxicity

Provided herein are compositions and methods to reduce toxicity resulting from pharmaceutical treatment, that can lead to increased risk of developing parkinson's disease (pd) and/or acceleration of pd-associated deterioration.. . ... Northwestern University

05/31/18 / #20180151515

System and method for stripline electrodes for thin-film characterization

Systems and methods provide a device for characterizing a thin film, including a conducting or insulating substrate, an active layer on the conducting or insulating substrate to be characterized, and a plurality of stripline electrodes on the active layer. The plurality of stripline electrodes include a pitch width of a same order as the thickness of the active layer and strip width smaller than the thickness of the active layer.. ... Northwestern University

05/24/18 / #20180145271

Flashing ratchets

Provided herein are flashing ratchets that produce transport based on the oscillating application of regularly-spaced, asymmetric potentials. In particular, devices are provided that transport electrons without the requirement of an overall source-drain bias favoring electron transport.. ... Northwestern University

05/17/18 / #20180134581

Metal-organic frameworks for adsorption of liquid phase compounds

The present invention provides for the use of a metal-organic framework (mof) in removing particular chemical species or compounds, in particular oxy-anions, from a liquid or liquid stream. In some embodiments, the mof is a zr-based mof, such as nu-1000, and the oxy-anions that are removed include, include, for example, oxy-anions of selenium, including selenite (seo32−) and selenate (seo42−); oxy-anions of antimony, including oxy-anions in either the sb[iii] (antimonite) or the sb[v] (antimonate) redox state; and oxy-anions of lead, including oxy-anions in either the pb[ii] or the pb[iv] redox state, such as pb(oh)62−, pb(oh)64−, pbo32−, and pbo22−. ... Northwestern University

05/17/18 / #20180133711

Minimally-invasive collection system for collecting biological samples for quantifying heavy metals, other toxicants, pathogens, and biomarkers

Disclosed are devices, kits, compositions, and methods for collecting, transporting, and detecting toxicants, pathogens, and biomarkers in a biological sample. The devices, kits, compositions and methods may be utilized to collect and transport dried blood samples from a skin prick and detect toxicants, pathogens, and biomarkers in the dried blood samples.. ... Northwestern University

05/17/18 / #20180132756

Medical evaluation system and method using sensors in mobile devices

A medical evaluation system includes an i/o module, a processing module, and an analysis module. The i/o module receives sensory data obtained by a motion sensor disposed in a mobile device carried by a patient at least when the patient is in a non-clinical environment. ... Northwestern University

05/10/18 / #20180129863

High throughput partial wave spectroscopic microscopy and associated systems and methods

The present technology provides methods, systems, and apparatuses to achieve high throughput and high speed acquisition of partial wave spectroscopic (pws) microscopic images. In particular, provided herein are high-throughput, automated partial wave spectroscopy (ht/a-pws) instruments and systems capable of rapid acquisition of pws microscopic images and clinical, diagnostic, and research applications thereof.. ... Northwestern University

05/10/18 / #20180128812

Compositions and methods for identifying metabolically active agents

The present invention relates to cells with altered cell cycle control. In particular, the present invention provides cells with altered cell cycle control and uses of such cells to identify metabolically active agents.. ... Northwestern University

05/10/18 / #20180125990

Materials for tissue regeneration

Provided herein are materials for the promotion of tissue regeneration, and methods of promoting tissue regeneration and wound healing therewith. In particular, materials displaying laminin-derived peptide sequences that facilitate cell migration into the material, and methods of use thereof, are provided.. ... Northwestern University

05/10/18 / #20180125924

Supramolecular glycosaminoglycans

Provided herein are glycosylated peptide amphiphiles (gpas), supramolecular glyconanostructures assembled therefrom, and methods of use thereof. In particular, provided herein are glycosaminoglycan (gag) mimetic peptide amphiphiles (pas) and supramolecular gag mimetic nanostructures assembled therefrom that mimic the biological activities of gags, such as heparin, heparan sulfate, hyaluronic acid etc.. ... Northwestern University

05/03/18 / #20180120982

Haptic device with indirect haptic feedback

A method of creating a haptic effect on a touch surface, the method including the steps of detecting a location of a first appendage and a second appendage on a touch surface, applying a mechanical force to the first and second appendages at the detected locations on the touch surface, modulating the amplitude of the mechanical force to adjust a friction force applied to the first appendage and second appendage to simulate a texture.. . ... Northwestern University

05/03/18 / #20180117502

Layer-by-layer sorting of rhenium disulfide via high-density isopycnic density gradient ultracentrifugation

Separation of rhenium disulfide nanomaterials and related fluid density gradient media.. . ... Northwestern University

05/03/18 / #20180117219

3d printing of biomedical implants

Provided herein are methods, compositions, devices, and systems for the 3d printing of biomedical implants. In particular, methods and systems are provided for 3d printing of biomedical devices (e.g., endovascular stents) using photo-curable biomaterial inks (e.g., or methacrylated poly(diol citrate)).. ... Northwestern University

05/03/18 / #20180117175

Templated nanoconjugates

The present disclosure is directed to compositions comprising templated nanoconjugates and methods of their use.. . ... Northwestern University

05/03/18 / #20180117151

Pulmonary intravascular non-classical monocytes mediate lung transplant ischemia-reperfusion injury

Disclosed are methods and compositions which may be utilized to inhibit and/or deplete non-classical monocytes during a transplantation procedure. The disclosed methods and compositions may be utilized in order to reduce damage to organs and tissues during a transplantation procedure and/or to improve the success rate of the transplantation procedure.. ... Northwestern University

04/19/18 / #20180104196

Endoxifen for local transdermal therapy to the breast

Disclosed are methods and topical formulations for treating and/or preventing cell proliferative diseases and disorders including breast cancer and ductal carcinoma is situ (dcis) using local transdermal therapy (ltt). The disclosed methods typically include administering topically to the breast or breasts of the patient a topical formulation comprising an effective dose of the tamoxifen metabolite, n-desmethyl-4-hydroxytamoxifen (i.e., endoxifen or enx) for treating breast cancer. ... Northwestern University

04/12/18 / #20180098952

Inactivators of toxoplasma gondii ornithine aminotransferase for treating toxoplasmosis and malaria

Disclosed are methods, compounds, and compositions for treating infection by an apicomplexan parasite that include administering a compound that selectively inactivates ornithine aminotransferase of the apicomplexan parasite. Specifically, the methods, compounds, compounds may be utilized for treating infection by toxoplasma gondii and toxoplasmosis and for treating infection by plasmodium falciparum and malaria. ... Northwestern University

04/05/18 / #20180096166

System and method for secure query processing for private data networks

Systems and methods enable two or more data providers that do not trust each other with their data to pool their data for analysis. The systems and methods can translate conventional database sql queries into secure multiparty computation so that the data providers can analyze their collective data without requiring any of them to disclose private information.. ... Northwestern University

04/05/18 / #20180094026

Methods of treating depression and other related diseases

The invention relates to methods for treating depression, anxiety, and other related diseases by administering a peptide nmdar partial agonist.. . ... Northwestern University

04/05/18 / #20180092988

Nanocarriers having surface conjugated peptides and uses thereof for sustained local release of drugs

Disclosed are biodegradable nanocarriers that have a net positive surface charge and zeta potential between about +2 to about +20 mv. The positive surface charge of the nanocarriers is provided by peptides that are covalently attached to the surface of the nanocarriers. ... Northwestern University

04/05/18 / #20180092894

Treatment of eosinophilic inflammatory disease

Provided herein are compositions and methods for the treatment of eosinophilic inflammatory diseases of the mucosal surfaces using proton pump inhibitors. In particular, administration of inhibitors of h,k-atpase (atp12a) provides treatment for eosinophilic inflammatory diseases.. ... Northwestern University

04/05/18 / #20180092761

Biomimetic and variable stiffness ankle system and related methods

A cam system for an assistive device and related methods are disclosed. The cam system may comprise a cam profile and a cam follower. ... Northwestern University

03/29/18 / #20180087039

Tissue factor (tf)-targeted nanotherapy

. . Provided herein are tissue factor (tf)-targeted nanofibers and methods of treating hemorrhage in a subject therewith. In particular, peptide amphiphiles (pas) are provided that comprise a tf-targeting peptide sequence and self-assemble under aqueous conditions into pa nanofibers displaying the tf-targeting sequence on the exterior of the nanofiber.. ... Northwestern University

03/29/18 / #20180085492

Antioxidant scaffolds for beta cell delivery

Provided herein are thermoresponsive citrate-based hydrogels and methods of use thereof for cell delivery. In particular, pancreatic islet cells entrapped within poly(polyethyleneglycol citrate-co-n isopropylacrylamide) (ppcn) hydrogels are provided herein, as well as methods of use thereof for extra-hepatic islet transplantation.. ... Northwestern University

03/29/18 / #20180085390

Polyvalent rna-nanoparticle compositions

The present invention concerns nanoparticles functionalized with duplex rna for a variety of uses, including but not limited to gene regulation. More specifically, the disclosure provides a new strategy for conjugating rna to a nanoparticle to achieve increased stability and activity.. ... Northwestern University

03/22/18 / #20180081083

Stress manipulated coating for figure reshape of optical substrates

A deposition system for forming a stress distributed coating layer is provided which comprises a deposition apparatus comprising a source from which a coating material emanates, the source configured to restrict a flux of the coating material towards a backside of an optical substrate; a holder configured to hold the optical substrate; a drive system configured to provide relative translation of the source and the optical substrate; and a bias voltage power supply operably coupled to the source and the optical substrate and configured to apply a bias voltage between the source and the backside of the optical substrate. A device is operably coupled to the deposition apparatus, the device comprising a processor; and a computer-readable medium operably coupled to the processor, the computer-readable medium having computer-readable instructions stored thereon that, when executed by the processor, cause the deposition apparatus to deposit the coating material onto the backside of the optical substrate and to adjust the bias voltage between the source and the backside of the optical substrate during the deposition of the coating material as a function of relative position of the source and the optical substrate to provide a stress distributed coating layer on the backside of the optical substrate.. ... Northwestern University

03/22/18 / #20180080058

Nanopatterned extracellular matrices enable cell-based assays with a mass spectrometric readout

The present disclosure provides methods in which adherent cells are treated with small molecules, cultured, lysed, and then analyzed by mass spectrometry to measure the activities of endogenous enzymes. The implementation of this method relies on the use of surfaces that are nanopatterned with cell adhesion ligands to mediate cell attachment and a peptide that is a substrate for the desired enzyme activity in the lysate.. ... Northwestern University

03/22/18 / #20180080030

Compositions and methods for correcting limb girdle muscular dystrophy type 2c using exon skipping

The invention is directed to one or more antisense polynucleotides and their use in pharmaceutical compositions in a strategy to induce exon skipping in the γ-sarcoglycan gene in patients suffering from limb-girdle muscular dystrophy-2c (lgm-d2c) or in patients at risk of such a disease. The invention also provides methods of preventing or treating muscular dystrophy, e.g., lgmd2c, by exon skipping in the gamma sarcoglycan gene using antisense polynucleotides. ... Northwestern University

03/22/18 / #20180079922

Ink compositions for fabricating objects from regoliths and methods of forming the objects

Ink compositions for fabricating objects from planetary regoliths and objects fabricated from the ink compositions are provided. The objects include flexible, elastomeric objects and hard objects. ... Northwestern University

03/22/18 / #20180078255

Indirect attachment of a needle to a mesh suture

A medical device includes a surgical needle, an elongated suture, and an intervening segment. The elongated suture has a first end proximate to the needle and a second end located away from the needle. ... Northwestern University

03/15/18 / #20180074080

Nanoparticles as catalytic substrates for real-time biosensing of human performance and diagnostic and therapeutic methods

Nanostructures having an inorganic core and a lipid layer capable of binding a lecithin:cholesterol acyltransferase (lcat) activator such as an apolipoprotein are provided herein. Methods of using the nanostructures and related devices and compositions for assessing the risk of developing a disease or condition or treating the disease or condition are also provided.. ... Northwestern University

03/15/18 / #20180074042

Devices and methods for filtering blood plasma

The present invention provides systems, devices, kits, and methods for separating blood plasma from whole blood. In particular, the present invention provides systems, devices, and methods for separating a fixed volume of blood plasma from whole blood with minimal energy input.. ... Northwestern University

03/15/18 / #20180073079

Compositions and methods for identifying depressive disorders

Provided herein are compositions, kits, and methods for the identification of depressive disorders. In particular, provided herein are compositions, kits, and methods for the detection or diagnosis of major depressive disorder.. ... Northwestern University

03/08/18 / #20180064697

Methods and compositions for modulating calcium channels

The present invention relates to methods and compositions for modulating calcium channels. In particular, the present invention provides methods and compositions for modulating (e.g., disrupting) cav1.3a calcium channels for research and therapeutic methods (e.g., treating dopaminergic diseases and conditions).. ... Northwestern University

03/08/18 / #20180064377

Soft, wearable microfluidic systems capable of capture, storage, and sensing of biofluids

The invention provides systems for handling biofluids including the transport, capture, collection, storage, sensing, and/or evaluation of biofluids released by tissue. Systems of some aspects provide a versatile platform for characterization of a broad range of physical and/or chemical biofluid attributes in real time and over clinically relevant timeframes. ... Northwestern University

03/01/18 / #20180059849

Touch interface device and method for applying controllable shear forces to a human appendage

A method of moving a plurality of appendages of an operator in contact with a touch surface including the steps of measuring a plurality of locations when the touch surface is touched by the plurality of appendages, moving the touch surface in a swirling motion by one or more actuators coupled with the touch surface, controlling a voltage on each of a plurality of electrodes disposed below the touch surface, controlling an electrostatic normal force acting on each of the appendages by adjusting the voltage applied to each of the plurality of appendages by each electrode lying beneath the appendage, synchronizing the electrostatic normal force generated by the voltage applied to each of the plurality of appendages with the swirling motion by basing a frequency of the swirling motion on the frequency of application of the electrostatic normal force.. . ... Northwestern University

03/01/18 / #20180059550

Heat actuated and projected lithography systems and methods

In accordance with an embodiment of the disclosure, a tip array can include an elastomeric tip substrate layer comprising a first surface and an oppositely disposed second surface, the tip substrate layer being formed from an elastomeric material; a plurality of tips fixed to the first surface, the tips each comprising a tip end disposed opposite the first surface, the tips having a radius of curvature of less than about 1 micron; and an array of heaters disposed on the second surface of the tip substrate layer and configured such that when the tip substrate layer is heated by a heater, a tip disposed in a location of a heated portion of tip substrate layer is lowered relative to a tip disposed in a location of an unheated portion of the tip substrate layer.. . ... Northwestern University

03/01/18 / #20180057884

Compositions and methods for identifying depressive disorders

Provided herein are compositions, kits, and methods for the identification of depressive disorders. In particular, provided herein are compositions, kits, and methods for the detection or diagnosis of major depressive disorder.. ... Northwestern University

02/22/18 / #20180051001

Tetrahydrothiophene-based gaba aminotransferase inactivators

Tetrahydrothiophene and related heterocyclic analogs and related methods for gaba aminotransferase inactivation.. . ... Northwestern University

02/22/18 / #20180050905

Sorting process of nanoparticles and applications of same

A sensing platform includes a substrate, an array of wells formed in the substrate, and sorted nanoparticles filling in the array of wells such that each well contains a single sorted nanoparticle, wherein the sorted nanoparticles are in a cluster state.. . ... Northwestern University

02/08/18 / #20180040711

Noncentrosymmetric metal electrodes for ferroic devices

A ferroelectric heterostructure may comprise a ferroelectric layer comprising a ferroelectric material and a first electrode layer comprising a first noncentrosymmetric metal, the first electrode layer disposed on the ferroelectric layer to form a ferroelectric-first electrode interface, wherein the ferroelectric layer is characterized by exhibiting an electric polarization and the first electrode layer is characterized by exhibiting polar ionic displacements and further wherein, a component of the polar ionic displacements of the first electrode layer is parallel to a component of the electric polarization of the ferroelectric layer.. . ... Northwestern University

02/08/18 / #20180039366

Touch interface device having an electrostatic multitouch surface and method for controlling the device

A touch interface device comprising a touch surface, a first electrode coupled with the touch surface, a second electrode coupled with the touch surface, where when an appendage of an operator touches the touch surface above both the first electrode and the second electrode a first actuation electrical potential from the first electrode and a second actuation electric potential from the second electrode establish electric fields that pass from one of the first and second electrodes directly through the outermost layer of the appendage and return to the other of the first and second electrodes via the outermost layer of the appendage.. . ... Northwestern University

02/08/18 / #20180038933

System and method for acquiring both t2*-weighted and t1-weighted data in a single acquisition using a single dose of contrast agent

Described here are systems and methods for obtaining measurements of both tissue perfusion and permeability with a magnetic resonance imaging (“mri”) system after the administration of a single dose of contrast agent. To this end, the mri system is directed to acquire t2-weighted or t2*-weighted data, during which the acquired signal values are monitored for a trigger event. ... Northwestern University

02/08/18 / #20180038799

Raman and surface enhanced raman spectroscopy for monitored drugs

The present disclosure provides systems, methods, and kits for identifying and determining the concentration of a drug of interest suspected of being present in an intravenous drug solution. An electrochemical surface enhanced raman (ec-sers) substrate is used to acquire an ec-sers spectrum of the intravenous drug solution. ... Northwestern University

02/08/18 / #20180037586

Substituted 4-methyl-pyrrolo[1,2-a]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity

Disclosed are new small molecules having a 4-methylpyrrrolo[1,2-a]pyrimidine-8-carboxamide core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising the small molecules which may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, including neurological diseases and disorders such as gaucher's disease and parkinson's disease. ... Northwestern University

02/01/18 / #20180031662

System and method for mapping and quantifying in-vivo blood flow stasis

Described here are systems and methods for producing an image that depicts blood flow stasis using magnetic resonance imaging (mri), doppler echocardiography, or other medical instruments for measuring flow velocities in a human body. A time series of three-dimensional (3d) image volumes is provided, where this time series of 3d image volumes contains flow velocity information at voxel locations in a 3d volume in a subject. ... Northwestern University

02/01/18 / #20180031583

Phosphatidylethanolamine-specific probes

Provided herein are phosphatidylethanolamine (pe)-specific probes and methods of use thereof. In particular, the present invention provides conjugates of pe binding moieties with detectable markers, and methods of use thereof to detect and/or characterize pe within cells.. ... Northwestern University

02/01/18 / #20180030539

Biomarkers predictive of predisposition to depression and response to treatment

The present invention relates generally to the identification of subjects with a predisposition to recurrent depression, predicting a subject's responsiveness to therapy, and determining whether a subject has remitted from depression following therapy. In particular, provided herein are biomarkers, methods, and kits for such uses.. ... Northwestern University

02/01/18 / #20180030538

Biomarkers predictive of predisposition to depression and response to treatment

The present invention relates generally to the identification of subjects with a predisposition to recurrent depression, predicting a subject's responsiveness to therapy, and determining whether a subject has remitted from depression following therapy. In particular, provided herein are biomarkers, methods, and kits for such uses.. ... Northwestern University

02/01/18 / #20180028446

Nanostructure enhanced targeting (nset) of inflammatory cells

The present invention provides nanomaterials for the specific targeting of immune cells. Methods of treating cardiac disease and inflammatory disease are also described.. ... Northwestern University

01/25/18 / #20180025124

Systems and methods for identifying content based on user interactions

Disclosed is an intelligent recommendation system for identifying and/or providing personalized one or more independent applications and/or healthcare related media content (e.g., multimedia content and applications involved in healthcare or the treatment of various health conditions of a user) to a plurality of user devices and/or client devices.. . ... Northwestern University

01/25/18 / #20180022878

Facile assembly of soft nanoarchitectures and co-loading of hydrophilic and hydrophobic molecules via flash nanoprecipitation

Described herein are flash nanoprecipitation methods capable of encapsulating hydrophobic molecules, hydrophilic molecules, bioactive protein therapeutics, or other target molecules in amphiphilic copolymer nanocarriers.. . ... Northwestern University

01/25/18 / #20180021040

Mesh suture

A medical device includes a surgical needle attached to an elongated mesh suture. The suture is constructed of macroporous flat wall that facilitates and allows tissue integration into the suture core subsequent to introduction to the body, thereby preventing suture pull-through and improving biocompatibility.. ... Northwestern University

01/25/18 / #20180020922

Devices, methods, and systems of functional optical coherence tomography

The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as oct. Generally, oct data is acquired and optical information is extracted from oct scans to quantitatively determine a flow rate of fluid in the target; angiography is also performed using one or more fast scanning methods to determine a concentration of one or more analytes. ... Northwestern University

01/18/18 / #20180019493

Three dimensional extrusion printed electrochemical devices

Solid oxide electrochemical devices, methods for making the electrochemical devices, and methods of using the electrochemical devices are provided. The electrochemical devices comprise a plurality of stacked functional layers that are formed by a combination of three-dimensional (3d) extrusion printing and two-dimensional (2d) casting techniques.. ... Northwestern University

01/18/18 / #20180017487

Biological tissue analysis by inverse spectroscopic optical coherence tomography

A method and system to measure and image the full optical scattering properties by inverse spectroscopic optical coherence tomography (isoct) is disclosed. Tissue is modeled as a medium with continuous refractive index (ri) fluctuation and such a fluctuation is described by the ri correlation functions. ... Northwestern University

01/18/18 / #20180016614

Highly productive one-pot system for the incorporation of non-standard amino acids into cell-free synthesized proteins

Disclosed are methods, systems, components, and compositions related to genomically recoded and engineered organisms. The disclosed genomically recoded and engineered organisms may be used to prepare extracts for use in platforms and methods for preparing sequence defined biopolymers in vitro. ... Northwestern University

01/18/18 / #20180016548

Acellular scaffolds for maturation of ipsc-hepatocytes

Provided herein are compositions and systems comprising induced pluripotent stem cell (ipsc)-derived hepatocytes and systems and methods for acellular maturation thereof. In particular, ipsc-derived hepatocytes are matured on decellularized extracellular matrix (ecm) to yield cells with enhanced hepatocytic biomarkers and functionality.. ... Northwestern University

01/11/18 / #20180013065

Optical discs as low-cost, quasi-random nanoimprinting templates for photon management

Photonic devices are provided comprising a photoactive layer and at least one additional layer, wherein a surface of the photoactive layer or a surface of the at least one additional layer has imprinted thereon a quasi-random pattern of nanostructures corresponding to a quasi-random pattern of nanostructures defined in a recording layer of a pre-written optical media disc. Methods of patterning a layer of a photonic device are also provided.. ... Northwestern University

01/11/18 / #20180011571

Haptic device with indirect haptic feedback

A method of imitating a texture on a touch surface, the method including the steps of sensing a position of a user's finger on the touch surface, modulating a coefficient of friction of the touch surface in response to the sensed position of a user's appendage relative to the touch surface and/or a derivative thereof, where the friction modulator does not alter the contour of the touch surface in a manner that is perceptible to a user's sight or touch.. . ... Northwestern University

01/11/18 / #20180010001

Enhanced conductivity, adhesion and environmental stability of printed graphene inks with nitrocellulose

Graphene ink compositions comprising nitrocellulose and related methods of use comprising either thermal or photonic annealing.. . ... Northwestern University

01/11/18 / #20180009870

Therapeutic targeting of set1b/compass pathway for treating cancers

Disclosed are methods for treating set1/compass-associated cancers characterized by expression of set1b/compass. The methods typically include administering a therapeutic amount of an inhibitor of the set1b/compass pathway and/or an agonist for a target that is negatively regulated by the set1b/compass pathway.. ... Northwestern University

01/11/18 / #20180008156

Systems, methods, and apparatus for esophageal panometry

Systems, methods, and apparatus for esophageal panometry are provided. An example method includes capturing measurement data including an area and a pressure of an esophageal body via a measurement device positioned with respect to the esophageal body; generating representations of the exported measurement data; analyzing the measurement data to determine esophageal reactivity based on the area and pressure; assessing esophageal function based on the determined esophageal reactivity; and outputting an indication of esophageal function.. ... Northwestern University

12/28/17 / #20170369851

Artificial ovary

Artificial ovaries comprising porous three-dimensional scaffolds are provided. Also provided are ink compositions and methods for printing the scaffolds. ... Northwestern University

12/28/17 / #20170369472

Map kinase modulators and uses thereof

The invention provides for novel map kinase inhibitors and compositions comprising the same. In some embodiments, the map kinase inhibitors are p38α map kinase inhibitors. ... Northwestern University

12/28/17 / #20170368377

Photoluminescent panthenol citrate biomaterials

Provided herein are compositions comprising panthenol-citrate containing materials. In particular, panthenol citrate compounds, oligomers, and polymers, and methods of use and synthesis thereof, are provided herein. ... Northwestern University

12/28/17 / #20170367982

High density lipoprotein functionalized magnetic nanostructures

Provided herein are compositions and methods for diagnosis and treatment of early-stage atherosclerotic plaques and reduction of plaques in arteries. In particular, provided herein are high-density-lipoprotein-functionalized magnetic nanostructures (hdl-mns) capable of (i) precise anatomic detection of atherosclerotic lesions, (ii) removal of excess cholesterol from macrophage cells in atherosclerotic plaque, and/or (iii) delivery of therapeutic agents to plaque locations, and methods of diagnosis and treatment of atherosclerosis.. ... Northwestern University

12/28/17 / #20170367596

Tonometry based blood pressure measurements using a two-dimensional force sensor array

Representative methods, apparatus and systems are disclosed for blood pressure and other vital sign monitoring using arterial applanation tonometry, including ambulatory blood pressure and other vital sign monitoring. A representative system comprises a wearable apparatus. ... Northwestern University

12/21/17 / #20170365557

Self-similar and fractal design for stretchable electronics

The present invention provides electronic circuits, devices and device components including one or more stretchable components, such as stretchable electrical interconnects, electrodes and/or semiconductor components. Stretchability of some of the present systems is achieved via a materials level integration of stretchable metallic or semiconducting structures with soft, elastomeric materials in a configuration allowing for elastic deformations to occur in a repeatable and well-defined way. ... Northwestern University

12/21/17 / #20170362167

Zirconium- and hafnium-based metal-organic frameworks as epoxide ring-opening catalysts

Metal-organic frameworks (mofs) and method of using the mofs to catalyze reactions involving epoxide ring-opening mechanisms are provided. The structure of the mofs can be represented by the formula: m6(μ3-ligand)8(ohx)8(tbapy)2, where m is zr or hf, the ligands are selected from hydroxo-, oxo- and aquo-ligands, and x is independently selected from 1 or 2.. ... Northwestern University

12/21/17 / #20170360992

Thromboresistant-anticoagulant extracellular matrix

Provided herein are bioactivated polymer/extracellular matrix (ecm) composites and methods of preparation and use thereof. In particular, heparinized cysteine-polymer/ecm composites, and methods of preparation and use thereof, are provided. ... Northwestern University

12/14/17 / #20170358795

Electrode material comprising graphene-composite materials in a graphite network

. . A durable electrode material suitable for use in li ion batteries is provided. The material is comprised of a continuous network of graphite regions integrated with, and in good electrical contact with a composite comprising graphene sheets and an electrically active material, such as silicon, wherein the electrically active material is dispersed between, and supported by, the graphene sheets.. ... Northwestern University

12/14/17 / #20170354711

High density lipoprotein nanoparticles for inflammation

The invention in aspects relates to methods of treating sepsis using hdl-np. The methods include the use of nanoparticles having a core and a lipid based shell with optimal lipids therein.. ... Northwestern University

12/14/17 / #20170354420

Intranasal occlusion device and methods of using the same

An intranasal occlusion device having an inflatable balloon within a sponge that is used to prevent drainage of fluid, such as blood and other fluids into the airway during sinus and nasal minor procedures or surgeries, and methods of using the device to occlude an intranasal cavity of a patient. The device provides for suction to remove the fluid and may facilitate office-based minor procedures or surgeries.. ... Northwestern University

12/07/17 / #20170352151

Spatiotemporal background phase correction for phase contrast velocity encoded mri

A computer-implemented method for performing spatiotemporal background phase correction for phase contrast velocity encoded magnetic resonance imaging includes performing a phase contrast magnetic resonance imaging scan of a region of interest within a patient to yield a complex image and calculating a plurality of filter cut-off frequencies based on physiological limits associated with the patient. A spatiotemporal filter is created based on the plurality of filter cut-off frequencies. ... Northwestern University

12/07/17 / #20170351318

System and method for associative power and clock management with instruction governed operation for power efficient computing

A system includes an arm core processor, a programmable regulator, a compiler, and a control unit, where the compiler uses a performance association outcome to generate a 2-bit regulator control values encoded into each individual instruction. The system can provide associative low power operation where instructions govern the operation of on-chip regulators or clock generator in real time. ... Northwestern University

12/07/17 / #20170349928

Methods for activating natural energy metabolism for improving yeast cell-free protein synthesis

Disclosed are compositions, methods, and kits for enhanced synthesis of a biological macromolecule in vitro using cell-free protein synthesis. The compositions, methods, and kits include or utilize: a cell-free extract; a phosphate-free energy source; and a phosphate source, and typically do not include an exogenous nucleoside triphosphate or an exogenous nucleoside diphosphate.. ... Northwestern University

12/07/17 / #20170349552

Treatment of amyotrophic lateral sclerosis

The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (als) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds.. ... Northwestern University

11/23/17 / #20170335335

Systems and methods for untargeted metabolomic screening

Provided herein are systems and methods for untargeted screening of metabolite products of biosynthetic gene clusters. In particular, systems and methods are provided for the detection of secondary metabolites and the correlation off such metabolites to the biosynthetic gene clusters responsible for the biosynthesis thereof.. ... Northwestern University

11/23/17 / #20170332935

Methods and systems for identifying non-penetrating brain injuries

The present disclosure provides methods for identifying non-penetrating brain injury in a subject, as well as methods for classifying a subject that received a hit to the body that transmitted an impulsive force to the brain as either having a non-penetrating brain injury or not, by analyzing one or more components of frequency-following response (ffr) following administration of an acoustic stimulus to the subject. In addition, the present disclosure provides methods for assessing a subject's recovery from a non-penetrating brain injury. ... Northwestern University

11/09/17 / #20170319650

Maspin-based inhibition of osteoclast activity and promotion of bone formation

Provided herein are compositions and methods for the treatment of bone disorders through the maspin-based inhibition of osteoclastogenesis and osteoclast activity and the promotion of bone formation.. . ... Northwestern University

10/26/17 / #20170308597

Systems and methods for enabling situational awareness for events via data visualization

Aspects of the present disclosure relate to data visualization, and more specifically, to technology that automatically visualizes various analytics and predictions generated for mass participation endurance events, or other events of interest.. . ... Northwestern University

10/26/17 / #20170307440

Devices, methods, and systems relating to super resolution imaging

Certain examples disclose systems and methods for imaging a target. An example method includes: a) activating a subset of light-emitting molecules in a wide field area of a target using an excitation light; b) capturing one or more images of the light emitted from the subset of the molecules illuminated with the excitation light; c) localizing one or more activated light emitting molecules using one or more single molecule microscopic methods to obtain localization information; d) simultaneously capturing spectral information for the same localized activated light emitting molecules using one or more spectroscopic methods; e) resolving one or more non-diffraction limited images of the area of the target using a combination of the localization and spectral information for the localized activated light emitting molecules; and 0 displaying the one or more non-diffraction limited images.. ... Northwestern University

10/26/17 / #20170306320

Methods for in vitro ribosome synthesis and evolution

Disclosed are methods, components, compositions, and kits for preparing and identifying engineered e. Coli ribosomes. ... Northwestern University

10/26/17 / #20170306258

Lubricant additives, lubricant compositions, and applications of same

A lubricant composition includes a base lubricant and a plurality of lubricant additive molecules. Each lubricant additive molecule includes a surface active group attractable to a target surface, and a carbon containing component connected to the surface active group, for providing a carbon source to form a carbon film on the target surface. ... Northwestern University

10/26/17 / #20170305998

Modified pigment epithelium-derived factor (pedf) peptides and uses thereof for treating neovascular diseases, inflammatory diseases, cancer, and for cytoprotection

Disclosed are modified pigment epithelium-derived factor (pedf) peptides, particulate carrier prodrugs thereof, and pharmaceutical compositions comprising the peptides or particulate carrier prodrugs. The peptides, particulate carrier prodrugs, and pharmaceutical compositions may be used to treat diseases and disorders that are amenable to treatment with anti-angiogenic agents, anti-tumorigenic agents, anti-fibrotic agents, chemotherapy-protecting agents, and immune stimulating agents. ... Northwestern University

10/26/17 / #20170305901

Therapeutic targeting of interleukin-1 receptor-associated kinase 4 (irak4) in cancers characterized by rearrangements in the mixed lineage leukemia gene (mll-r)

Disclosed are methods for treating cancers associated with rearrangements in the mixed lineage leukemia gene (mll-r), including mll-r leukemia. The methods typically include administering a therapeutic amount of one or more therapeutic agents that inhibit the biological activity of one or more members of the interleukin-1 signaling pathway such inhibitors of interleukin-1 receptor-associated kinase 4 (irak4).. ... Northwestern University

10/26/17 / #20170305813

Sulfur as a selective oxidant in oxidative hydrocarbon processing over oxide/chalcogenide catalysts

Methods for oxidative coupling of methane using metal oxide catalysts and a sulfur oxidant.. . ... Northwestern University

10/26/17 / #20170304587

Phase-locked loop to enhance slow wave sleep

Certain examples provide systems and methods to enhance slow wave sleep. An example method includes identifying a sleep stage for slow wave sleep in a subject being monitored. ... Northwestern University

10/26/17 / #20170304232

Endoxifen for local transdermal therapy to the breast

Disclosed are methods and topical formulations for treating and/or preventing cell proliferative diseases and disorders including breast cancer and ductal carcinoma is situ (dcis) using local transdermal therapy (ltt). The disclosed methods typically include administering topically to the breast or breasts of the patient a topical formulation comprising an effective dose of the tamoxifen metabolite, n-desmethyl-4-hydroxytamoxifen (i.e., endoxifen or enx) for treating breast cancer. ... Northwestern University

10/12/17 / #20170293009

Magnetic barcode imaging

Provided herein is technology relating to magnetic resonance imaging contrast agents and particularly, but not exclusively, to methods and systems for visualizing one or more magnetic resonance imaging contrast agent.. . ... Northwestern University

10/12/17 / #20170290944

Promotion of wound healing

The present invention provides compositions and methods that promote wound healing in a subject with a cutaneous injury. In particular, the present invention provides systemic and/or local administration of one or more compositions that cause ganglioside depletion (e.g., glucosylceramide synthase (gcs) inhibitors) for the treatment of cutaneous wounds.. ... Northwestern University

10/05/17 / #20170289707

Hearing assistance device control

A hearing assistance device may be a hearing aid worn on a person or a mobile device. The hearing assistance device may perform a hearing assistance algorithm based on signal processing parameters. ... Northwestern University

10/05/17 / #20170283467

Programmable polypeptide and nucleic acid nanoparticles

Provided herein are polypeptides that self-assemble into nanoparticles upon binding to nucleic acids. The nanoparticles find use, for example in the delivery of the nucleic acids into cells.. ... Northwestern University

10/05/17 / #20170281798

Synthetic scaffolds for metastasis detection

Provided herein are synthetic scaffolds engineered to function as a pre-metastatic niche to detect metastasis. In particular, synthetic scaffolds described herein provide detection of the earliest events in metastasis, thereby enabling treatment of metastasis before the disease burden increases.. ... Northwestern University

10/05/17 / #20170281680

Scaffold delivery of immune suppressors and transplant material for control of transplant rejection

The present invention provides compositions, devices, and methods for the coordinated delivery of transplant material and immune suppressors for control of transplant rejection. In particular embodiments, immune suppression cells (e.g., regulatory t cells) and transplant material (e.g., cells, tissue, etc.) are provided within a delivery scaffold for transplant into a subject.. ... Northwestern University

09/28/17 / #20170275278

Mammalian and bacterial nitric oxide synthase inhibitors

Disclosed are compounds that are shown to inhibit the biological activity of nitric oxide synthases (noss). Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds and pharmaceutical compositions for treating a subject in need thereof. ... Northwestern University

09/21/17 / #20170269755

Haptic device with controlled traction forces

A haptic device comprising a substrate having a surface, a first actuator that modulates a friction experienced by a user's finger touching the substrate surface, a second actuator that oscillates the substrate surface laterally, such that the combined effect of the first and second actuator is a net shear force applied to the user's finger, a finger position sensor that detects and measures location of the user's finger relative to the substrate surface, and a control device that receives at least one parameter related to the location of the user's finger and controls the first actuator and second actuator to simulate the feel of a shape different from that of the substrate.. . ... Northwestern University

09/21/17 / #20170269172

Group iii-v ferromagnetic/non-magnetic semiconductor heterojunctions and magnetodiodes

Ferromagnetic group iii-v semiconductor/non-magnetic group iii-v semiconductor heterojunctions, with a magnetodiode device, to detect heterojunction magnetoresistance responsive to an applied magnetic field.. . ... Northwestern University

09/14/17 / #20170260587

Sqstm1 mutations in amyotrophic lateral sclerosis

Provided herein is technology relating to diagnosing, monitoring, and treating disease and particularly, but not exclusively, to methods, compositions, and kits for diagnosing, monitoring, and treating amyotrophic lateral sclerosis by detecting and identifying mutations in the gene sqstm1 and providing therapies by targeting aberrant biological functions related to mutant forms of sqstm1.. . ... Northwestern University

09/14/17 / #20170260192

Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis

The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (i), wherein r1, r2, r3, and r4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.. ... Northwestern University

09/14/17 / #20170260165

2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase

Imidazolyl-pyrimidine and related compounds, as can utilize heme-iron coordination in the selective inhibition of neuronal nitric oxide synthase.. . ... Northwestern University

09/14/17 / #20170258880

Peptide conjugated particles

The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (plg) particles in particular, plg particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).. . ... Northwestern University

09/14/17 / #20170258870

Limp-2 based peptides and related uses

Disclosed are limp-2 peptides, limp-2 polypeptides, variants thereof, and pharmaceutical compositions comprising the limp-2 peptides, limp-2 polypeptides, or variants thereof. The disclosed peptides and polypeptides preferably comprise an amino acid sequence that is sufficient for providing a biological activity associated with limp-2, which may include binding and/or activating biological molecules such as β-glucocerebrosidase and binding viral protein 1 (vp1) of enterovirus 71 (e71) or coxsackievirus a16 (ca16). ... Northwestern University

09/07/17 / #20170254817

Biomarkers in nasal exhaled breath

A method of diagnosing or assessing risk of a tauopathy in a person is disclosed. The method may comprise collecting a nasal sample of exhaled breath from the person's nose, analyzing the nasal sample to detect the presence of tau protein in the sample, and determining the concentration of tau protein in the nasal sample, wherein the tau protein concentration in the nasal sample indicates susceptibility to the tauopathy.. ... Northwestern University

09/07/17 / #20170253581

Substituted heterocycles as c-myc targeting agents

Disclosed are substituted heterocycles compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-myc and may be utilized as therapeutics for treating cancer and cell proliferative disorders.. ... Northwestern University

09/07/17 / #20170253486

Stable aqueous dispersions of optically and electronically active phosphorene

Methods for the preparation of few-layer phosphorene, compositions thereof and related devices fabricated therefrom.. . ... Northwestern University

08/31/17 / #20170249014

Interfaces and methods of digital composition and editing of textures for rendering on tactile surfaces

This disclosure provides designer interfaces that present condensed representations of texture functions, the representations displaying selected control points that manipulate the representations, an algorithm that computes a texture function based on the positions of said selected control points, and the texture function generating a signal to control a force on an appendage of a user that touches a tactile surface, and methods of using the designer interfaces.. . ... Northwestern University

08/24/17 / #20170239202

(s)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, and related compounds as gaba aminotransferase inactivators for the treatment of epilepsy, addiction and hepatocellular carcinoma

Cyclopentene carboxylic acid-related compounds as gaba-at inhibitors for treatment of various addictions, disorders and disease states.. . ... Northwestern University

08/17/17 / #20170232109

Protein/oligonucleotide core-shell nanoparticle therapeutics

The present disclosure is directed to core-shell nanoparticles, compositions comprising core-shell nanoparticles, and methods of their use.. . ... Northwestern University

08/10/17 / #20170229742

Protective cathode coatings for lithium-ion batteries

Cathode coatings for lithium ion batteries, cathodes coated with the coatings, and lithium ion batteries incorporating the coated cathodes are provided. The coatings, which are composed of binary, ternary, and higher order metal oxides and/or metalloid oxides, can reduce the hydrofluoric acid (hf)-induced degradation of the electrolyte and/or cathodes, thereby improving the performance of lithium ion batteries, relative to lithium ion batteries that employ bare cathodes.. ... Northwestern University

08/10/17 / #20170227947

Automated toolpath generation method for double sided incremental forming

An automated method for generating toolpaths in double sided incremental forming (dsif) operations is disclosed which uses a geometrically constructed map to build a structure of all the geometric features that is capable of tracking and forming the features in the correct order while simultaneously keeping track of the location of the virgin material. The aforementioned method allows toolpaths for complex. ... Northwestern University

08/10/17 / #20170224239

Cycle length iteration for the detection of atrial activations from electrogram recordings of atrial fibrillation

A method is provided of analyzing a cardiac electrogram using a computer. In one step, a determination is made as to a plurality of cycle lengths between a plurality of activation peaks of the cardiac electrogram. ... Northwestern University

08/03/17 / #20170218174

Immobilization of an active agent on a substrate using compounds including trihydroxyphenyl groups

The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. ... Northwestern University

08/03/17 / #20170217796

Compounds for lithium extraction via ion exchange

Methods for extracting lithium from solutions containing lithium ions via reversible cation exchange with h+ are provided. The methods utilize metal oxide or metalloid oxide cation exchange materials having an active sublattice that preferentially bind li+ cations, relative to both h+ and na+, in a sample solution and preferentially bind h+, relative to li+, in an acidic solution.. ... Northwestern University

08/03/17 / #20170216249

Substituted phenyl aziridine precursor analogs for inhibiting androgen-independent prostate cancer cell growth

Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one or more substituted phenyl aziridine precursors, their respective aziridines, analogs thereof, derivatives thereof, or pharmaceutically acceptable salts thereof such as cpda. ... Northwestern University

07/27/17 / #20170213355

Method for acquiring intentionally limited data and the machine learning approach to reconstruct it

Aspects of the present disclosure involve a data capturing and processing system that intentionally captures data and/or data sets with missing pieces of information. The data and/or datasets may include various types of data, such as one-dimensional signals, two-dimensional images (or other images), and/or three-dimensional structures. ... Northwestern University

07/27/17 / #20170212992

Systems and methods for generating high resolution probabilistic raster maps for electronic health record and other data associated with a geographical region

Described here are systems and methods for generating probabilistic maps that depict the probability distribution of data across a geographical region. More particularly, the systems and methods described here are capable of generating probabilistic maps of associated data at finer geographical resolution than is available for the associated data and are also capable of estimating and outputting related errors at that same geographical resolution.. ... Northwestern University

07/27/17 / #20170209622

Graphene-based ink compositions for three-dimensional printing applications

Electrically conducting, biocompatible, biodegradable tissue growth comprising graphene flakes in a polymeric matrix are provided.. . ... Northwestern University

07/27/17 / #20170209604

Method for detecting soluble oligomeric amyloid beta

A method for detecting soluble oligomeric amyloid β in a subject using, e.g., pet is provided.. . ... Northwestern University

07/27/17 / #20170209252

Medical devices, systems, and kits for the medialization of a vocal cord

Medical devices, systems, methods, and kits for the medialization of a vocal cord are described. A method comprises creating a passageway in thyroid cartilage of a patient, advancing a light source through the passageway, activating the light source, viewing light emitted from the light source to confirm placement of the passageway relative to the vocal cord, and advancing a medical device through the passageway to move the vocal cord toward a midline of the larynx of the patient.. ... Northwestern University

07/20/17 / #20170205401

Yeast-based biosensor

Provided herein are compositions and systems comprising yeast-based biosensors (ybbs) and methods of use thereof. In particular, ybbs are provided for the detection and/or quantification of an analyte (e.g., peptide analyte) in a sample (e.g., a biological sample, environmental sample, etc.). ... Northwestern University

07/20/17 / #20170203369

Synthesis of uniform anisotropic nanoparticles

Methods of synthesizing various metal nanoparticle structures having high uniformity, using iterative reduction and oxidation conditions, is provided herein.. . ... Northwestern University

07/13/17 / #20170198290

Anti-inflammatory treatment via inhibition of endothelial cell kinesin light chain 1, variant 1 (klc1c)

Provided herein are compositions and methods for the inhibition of endothelial cell kinesin light chain 1, variant 1 (klc1c) expression and/or activity, and treatment or prevention of inflammation therewith.. . ... Northwestern University

07/06/17 / #20170194982

System and method for energy efficient time domain signal processing

Time domain signal processing (tdsp) encodes information into time rather than voltage with high efficiency. Circuit level design techniques can also reduce the area and energy consumption of tdsp. ... Northwestern University

07/06/17 / #20170194765

Monolithical widely tunable quantum cascade laser devices

Monolithic, wavelength-tunable qcl devices are provided which comprise a substrate, an array of qcls formed on the substrate and an optical beam combiner formed on the substrate electrically isolated from the array of qcls. In embodiments, the qcl devices are configured to provide laser emission in the range of from about 3 μm to about 12 μm, a wavelength tuning range of at least about 500 cm−1, and a wavelength tuning step size of about 1.0 nm or less.. ... Northwestern University

07/06/17 / #20170191128

Tissue molecular signatures of kidney transplant rejection

By a genome-wide gene analysis of expression profiles of known or putative gene sequences in kidney biopsy samples, the present inventors have identified a consensus set of gene expression-based molecular biomarkers for distinguishing kidney transplantation patients who have acute rejection (ar), acute dysfunction no rejection (adnr), chronic allograft nephropathy(can), or transplant excellent/normal (tx). These molecular biomarkers are useful for diagnosis, prognosis and monitoring of transplantation patients.. ... Northwestern University

07/06/17 / #20170188818

Devices, methods, and systems of functional optical coherence tomography

The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as oct. Generally, oct data is acquired and optical information is extracted from oct scans to quantitatively determine both a flow rate of fluid in the target and a concentration of one or more analytes. ... Northwestern University

06/29/17 / #20170183735

Molecular signatures for distinguishing liver transplant rejections or injuries

By a genome-wide gene analysis of expression profiles of known or putative gene sequences in peripheral blood and biopsy samples, the present inventors have identified a consensus set of gene expression-based molecular biomarkers for distinguishing liver transplantation patients who have acute rejection (ar), hepatitis c virus recurrence (hcv-r), both ar/hcv-r, or acute dysfunction no rejection (adnr). These molecular biomarkers are useful for diagnosis, prognosis and monitoring of liver transplantation patients.. ... Northwestern University

06/29/17 / #20170182018

Treatment for dopaminergic disorders

The present invention provides systems, compositions and methods for treatment of dopaminergic disorders (e.g., parkinson's disease) using the combination of a first compound that inhibits a voltage-gated calcium channel of the type cav1.3 (e.g., a dihydropyridine such as isradipine), and a second compound that is monoamine oxidase inhibitor and/or is a nitric oxide synthase inhibitor (e.g., rasagiline or derivative thereof).. . ... Northwestern University

06/22/17 / #20170181112

System and method for resolving neighborhood wireless network affairs with radio signals

A system and method include a wireless node with a scheduler and a harmonizing controller connected with the node. The harmonizing controller includes a processor and a memory, where the memory stores instructions, which when executed by the processor, causes the processor to receive a radio signal, process the radio signal to determine bits of the signal, and synchronize a wireless schedule of the scheduler with a schedule of other nodes based on the bits to perform neighborhood harmonization.. ... Northwestern University

06/22/17 / #20170173226

Immobilization of an active agent on a substrate

The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. ... Northwestern University

06/22/17 / #20170172440

Contribution of oxidative stress to af electrograms

The invention relates generally to methods of detecting reactive oxygen species (ros) in cardiac tissue and treatment modalities for ablating ros-associated tissue in cardiac disease. The methods rely upon targeting ros-associated cardiac tissue for ablation and/or gene therapy in a subject using analytical tools based upon a plurality of recorded atrial egms for a tissue to assess ros content and underlying af organization as a function of ros blockade conditions.. ... Northwestern University

06/15/17 / #20170168572

Haptic display with simultaneous sensing and actuation

Touch interface devices and methods for producing multi-point haptics utilizing simultaneous sensing and actuation are disclosed. In one configuration, one or more electrodes connected to a front surface of a substrate are arranged in a pattern and connected to an electronic controller configured to produce a haptic effect by applying one or more voltages to the electrodes, and measure the locations of one or more touch points by applying one or more voltages to the electrodes. ... Northwestern University

06/15/17 / #20170166756

Surface-independent, surface-modifying, multifunctional coatings and applications thereof

The present invention provides a surface-independent surface-modifying multifunctional biocoating and methods of application thereof. The method comprises contacting at least a portion of a substrate with an alkaline solution comprising a surface-modifying agent (sma) such as dopamine so as to modify the substrate surface to include at least one reactive moiety. ... Northwestern University

06/01/17 / #20170152228

Screening methods for the binding affinity of chemical entities to biological molecules and nedd4-1 inhibitors identified by the screening methods

Disclosed are methods for preparing and screening for an inhibitor of the activity of a biological molecule having a catalytic or non-catalytic cysteine residue. The methods including preparing a library of candidate inhibitor molecules by conjugating an electrophile to a plurality of drug molecules where the library of candidate inhibitor molecules thus formed react with cysteine residues. ... Northwestern University

05/18/17 / #20170141333

Gate-tunable p-n heterojunction diode, and fabrication method and application of same

A method of fabricating a diode includes forming a first semiconductor layer having a first portion and a second portion extending from the first portion on a substrate; forming first and second electrodes on the substrate, the first electrode extending over and being in contact with the first portion of the first semiconductor layer; forming an insulting film to cover the first electrode and the first portion of the first semiconductor layer; and forming a second semiconductor layer having a first portion and a second portion extending from the first portion on the substrate. The second portion of the second semiconductor layer overlapping with the second portion of the first semiconductor layer to define a vertically stacked heterojunction therewith. ... Northwestern University








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