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Ohio State Innovation Foundation patents


Recent patent applications related to Ohio State Innovation Foundation. Ohio State Innovation Foundation is listed as an Agent/Assignee. Note: Ohio State Innovation Foundation may have other listings under different names/spellings. We're not affiliated with Ohio State Innovation Foundation, we're just tracking patents.

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Mirna biomarkers for radiation biodosimetry

Disclosed herein are mirna biomarkers and methods for measuring exposure of a mammalian subject to ionizing radiation using a cell-free biological sample. Also disclosed are dosimeters and methods for triaging and treating a subject exposed to ionizing radiation.. ... Ohio State Innovation Foundation

Methods and compositions relating to anti-nucleolin recombinant immunoagents

Disclosed herein are methods and compositions related to single chain antibody fragments which specifically bind nucleolin (ncl). Also disclosed are treating and diagnosing diseases using single chain antibody fragments that bind nucleolin.. ... Ohio State Innovation Foundation

Selective media and uses thereof

The present embodiments provide for media useful for selection and enrichment of salmonella species. In a particular embodiment, the medium is a minimal medium that includes fructose-asparagine as the sole nutrient source. ... Ohio State Innovation Foundation

Immobilization of biomolecules by self-assembled nanostructures

Disclosed are nanostructures such as carboxysomes that encapsulate rubisco and carbonic anhydrase to provide a protected environment to maximize co2 assimilation. Conditions are disclosed were rubisco can be sequestered into a variety of self-assembling nanotubes. ... Ohio State Innovation Foundation

Compositions and methods for treating and preventing porcine reproductive and respiratory syndrome

Disclosed herein are methods and compositions for treating or preventing porcine reproductive and respiratory syndrome (prrs) infection in a subject.. . ... Ohio State Innovation Foundation

Compositions and methods for inhibiting leishmania

Compositions and methods for inhibiting leishmaniasis using ais are provided. Aspects provide compositions and methods for administering ais alone or in combination with other compounds to infected hosts.. ... Ohio State Innovation Foundation

Rewriting forms for constrained interaction

The innovation describes and discloses methods and systems that improve system performance for technical communication systems by providing transformed forms from input form attributes and a plurality of target technical display environments. Since certain technical display environments may have constraints that provide limitations in the visualization and interactions of original forms designed for a purpose that does not take into account the possible variety of technical display environments, the disclosed innovation provides a transformed structure that is rendered in a target constrained technical communication environment. ... Ohio State Innovation Foundation

Galvanotaxis assay for quantitative assessment of the metastatic potential of cancer cells

An apparatus and method for accelerating and/or inhibiting the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of cells without the need for chemokines or glucose. The present invention can also be used to study and quantify the metastatic potential of different cell lines.. ... Ohio State Innovation Foundation

Agile tooling

A system and manufactures are provided that augment various manufacturing processes by combining skinning techniques, for example from additive manufacturing methods, with modular substructures in order to provide cost and development time saving while not sacrificing end product material characteristics. Modular substructures provide a range of benefits from wide adaptability and reusability, to customized cooling channels within tooling systems. ... Ohio State Innovation Foundation

Anatomical articulator for dental diagonostic method and prosthetic reconstruction

An anatomical articulator for modeling a temporomandibular joint includes a lower base portion comprising at least one upright support. A set of replica condyles produced from digital data representing a patient jaw structure is connected to the at least one upright support. ... Ohio State Innovation Foundation

Polymeric membranes for separation of gases

Membranes, methods of making the membranes, and methods of using the membranes are described herein. The membranes can comprise a gas permeable support layer, optionally an inorganic layer disposed on the support, and a selective polymer layer disposed on the inorganic layer. ... Ohio State Innovation Foundation

Benzene-1,3,5-tricarboxamide derivatives and uses thereof

The present invention relates to compounds, compositions, lipid-like nanoparticles, and methods for delivery of therapeutic, diagnostic, or prophylactic agents (for example, a polynucleotide).. . ... Ohio State Innovation Foundation

Zeolitic materials including paired lewis acid catalytic sites

Disclosed are zeolitic materials that include a microporous crystalline framework substituted with one or more paired lewis acid sites. Each of the one or more paired lewis acid sites within the zeolitic material can comprise a first lewis acid metal center and a second lewis acid metal center. ... Ohio State Innovation Foundation

Methods for the separation of co2 from a gas stream

Disclosed herein are 2-stage membrane separation methods for capturing co2 from a feed gas. The methods can employ two selectively permeable membranes, which may be the same or different. ... Ohio State Innovation Foundation

05/10/18 / #20180127737

Non-contact system for accelerating wound healing using an electromagnetic coil to induce an electric field transverse to an axis of the wound

A system for accelerating the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of cells. The system of the present invention accelerates the healing of wounds by electrotaxis of cells.. ... Ohio State Innovation Foundation

05/10/18 / #20180125442

Computed tomography (ct)-based elastography

Systems and methods are provided for ct-based elastography. A ct gantry is rotated while acquiring ct image data at a first frequency while tissue vibration is induced at a second vibrational frequency. ... Ohio State Innovation Foundation

05/10/18 / #20180125432

Electromagnetic system and method

Differences of electromagnetic (em) properties between healthy and cancerous tissues allow detection of abnormal conditions occurring in a tissue of an animal, for example, intra-operative cancer detection. By using a time-varying em field, electrical eddy currents are generated in the tissue sample, and assessed using phase-sensitive detection. ... Ohio State Innovation Foundation

05/03/18 / #20180123480

Enhanced flyback converter

A dc/dc flyback converter that exhibits reduced switch and transformer voltage stresses in comparison to known flyback converters. The flyback converter also employs soft switching. ... Ohio State Innovation Foundation

05/03/18 / #20180119255

High-entropy alcrtiv alloys

The present disclosure relates to relates generally to metal alloys. The present disclosure relates more particularly to high entropy alloys having relatively high strength and relatively low weight. ... Ohio State Innovation Foundation

05/03/18 / #20180118957

Liquid impregnated surfaces for liquid repellancy

Articles including repellent surfaces and methods of making and using these articles are disclosed. The repellant surface can comprise a polymer having a roughened surface and a fluorinated silane and a lubricating liquid deposited on the roughened surface. ... Ohio State Innovation Foundation

05/03/18 / #20180117146

Egfr-directed car therapy for glioblastoma

Glioblastoma (gb) remains the most aggressive primary brain malignancy; brain metastasis, such as breast cancer brain metastases (bcbms), are also aggressive and are associated with poor prognosis. Adoptive transfer of chimeric antigen receptor (car)-modified immune cells has emerged as a promising anti-cancer approach, yet the potential utility of car-engineered cells to treat brain cancers has not been explored. ... Ohio State Innovation Foundation

04/12/18 / #20180099874

Hierarchically porous aluminosilicate materials

Disclosed are methods of synthesizing a hierarchically porous aluminosilicate materials. Methods for synthesizing a hierarchically porous aluminosilicate material can comprise (i) combining, in aqueous solution, a base, an aluminum source, and silicon source to form a precursor gel; (ii) removing water from the precursor gel to form a nucleated gel; and (iii) reacting the nucleated gel at a temperature of from 0° c. ... Ohio State Innovation Foundation

04/12/18 / #20180099043

Methods to improve induction of iga antibodies by vaccines

A vaccine composition is disclosed that contains a vaccine antigen and a neutrophil inhibitor in amounts effective to promote an iga response to the antigen in a subject. Also disclosed is a method for enhancing immune response to a vaccine antigen in a subject that involves co-administering to the subject the vaccine antigen and an adjuvant composition comprising a neutrophil inhibitor in an amount effective to promote an iga response to the vaccine antigen in the subject.. ... Ohio State Innovation Foundation

03/29/18 / #20180088078

Miniaturized gas sensor device and method

Various embodiments of a gas sensor device and method of fabricating a gas sensor device are provided. In one embodiment a gas sensor device includes a base substrate, an electrolyte layer disposed on the base substrate and a plurality of potentiometric sensor units electrically coupled to the base substrate. ... Ohio State Innovation Foundation

03/29/18 / #20180088077

Miniaturized gas sensor device and method

Various embodiments of a gas sensor device and method of fabricating a gas sensor device are provided. In one embodiment a gas sensor device includes a base substrate, an electrolyte layer disposed on the base substrate and a plurality of potentiometric sensor units electrically coupled to the base substrate. ... Ohio State Innovation Foundation

03/29/18 / #20180088076

Miniaturized gas sensor device and method

Various embodiments of a gas sensor device and method of fabricating a gas sensor device are provided. In one embodiment a gas sensor device includes a base substrate, an electrolyte layer disposed on the base substrate and a plurality of potentiometric sensor units electrically coupled to the base substrate. ... Ohio State Innovation Foundation

03/29/18 / #20180086803

Engineered calmodulin for treatment of ryanopathies

Compositions and methods are disclosed for altering the binding affinity of calmodulin for ryanodine receptor 2 (ryr2). As disclosed herein, these therapeutic calmodulin (tcam) proteins can be used to correct ryanopathies by prolonging the ryr2 refractory period. ... Ohio State Innovation Foundation

03/22/18 / #20180083813

Frequency-independent receiver and beamforming technique

Example systems and methods described herein relate to radio communication architectures and techniques for beamforming and down-conversion without a priori knowledge of the source location or frequency. An example radio receiver includes a plurality of antenna elements that include a first element, a second element, and a third element. ... Ohio State Innovation Foundation

03/22/18 / #20180080441

Method and system for multi-stage compression of a gas using a liquid

A method of compressing a gas includes pumping, using a pump, at least a portion of a liquid contained in a first chamber to a second chamber containing a gas at a first pressure such that the portion of the liquid pumped into the second chamber compresses the gas in the second chamber to a second pressure greater than the first pressure, wherein the portion of the liquid pumped into the second chamber is admitted into the second chamber so that the admitted liquid flows along an internal surface of the second chamber.. . ... Ohio State Innovation Foundation

03/15/18 / #20180076354

Ultraviolet light emitting diodes with tunnel junction

An example ultraviolet (uv) light emitting diode (led) is described herein. The uv led can include an n-doped contact region, an active region configured to emit uv light that is arranged between an n-doped region and a p-doped region, and a tunnel junction. ... Ohio State Innovation Foundation

03/15/18 / #20180074001

Displacement current phase tomography for imaging of lossy medium

A system and method for displacement current phase tomography. The present system invention obtains a linear relationship between mutual displacement current from a sensor (output current of the measuring electrode terminals) and the area (or volume) of an object to be imaged in the imaging domain. ... Ohio State Innovation Foundation

03/08/18 / #20180066238

Live attenuated vaccines for pneumoviruses and related methods and materials

Described herein are mutant pneumoviruses comprising a nucleotide sequence which encodes a mutated zinc binding motif in an m2-1 protein of the pneumovirus, wherein the zinc binding motif is mutated relative to wild-type pneumovirus. The mutant pneumoviruses described herein grow to high titer in cell culture, are genetically stable, are attenuated in vitro and in vivo, and are highly immunogenic. ... Ohio State Innovation Foundation

03/08/18 / #20180065101

Systems and methods for partial or complete oxidation of fuels

A system used for converting multiple fuel feedstocks may include three reactors. The reactor system combination can be so chosen that one of the reactors completely or partially converts the fuel while the other generates the gaseous product required by utilizing the gaseous product from the second reactor. ... Ohio State Innovation Foundation

03/01/18 / #20180057950

Materials and methods for the electrochemical reduction of carbon dioxide

Disclosed are methods for electrochemically reducing carbon dioxide to provide a product. The methods can comprise contacting the carbon dioxide with an electroreduction catalyst in an electrochemical cell, and applying a potential to the electrochemical ceil to form the product. ... Ohio State Innovation Foundation

02/22/18 / #20180052460

Method for controlling autonomous valet system pathing for a motor vehicle

A method for autonomously parking or un-parking a motor vehicle includes receiving a map of a parking area having a first temporary obstruction zone, determining a starting location of the motor vehicle relative to the parking area, selecting a destination location within the parking area, setting the first temporary obstruction zone as operative or inoperative, generating a path from the starting location to the destination location, wherein the path does not enter the first temporary obstruction zone when operative, and driving the motor vehicle autonomously along the path from the starting location of the motor vehicle to the destination location.. . ... Ohio State Innovation Foundation

02/22/18 / #20180052459

Method for autonomously parking a motor vehicle for head-in, tail-in, and parallel parking spots

A method for autonomously parking a motor vehicle in various types of parking spots includes the steps of receiving a map of a parking area, locating the motor vehicle within the parking area, selecting a parking spot within the parking area, generating a node tree from the location of the motor vehicle to the parking spot, selecting a path from the node tree, wherein the path connects the location of the motor vehicle to the parking spot, autonomously driving the motor vehicle along the path from the location of the motor vehicle to an intermediate location on the path, and performing a parking maneuver into the parking spot from the intermediate location. The parking maneuver may be a head-in, tail-in, or parallel parking maneuver.. ... Ohio State Innovation Foundation

02/22/18 / #20180050691

Optimized path planner for an autonomous valet parking system for a motor vehicle

A method for autonomously parking or un-parking a motor vehicle includes locating the motor vehicle relative to a parking area, selecting a destination location within the parking area, generating a path from the location of the motor vehicle to the destination location, wherein the path includes a plurality of linked nodes, each node having a cost associated therewith, wherein the cost of a child node is equal to an inherited cost plus a base cost and a change cost, wherein the change cost is a function of characteristics of a parent node, and autonomously driving the motor vehicle along the path from the location of the motor vehicle to the destination location.. . ... Ohio State Innovation Foundation

02/22/18 / #20180050690

Method for autonomously parking and un-parking a motor vehicle

A method for autonomously parking or un-parking a motor vehicle includes the steps of locating the motor vehicle within a parking area, setting a destination location within the parking area, generating and setting a path from the location of the motor vehicle to the destination location, and autonomously driving the motor vehicle along the path. The path is generated by (a) generating a first set of nodes from the location of the motor vehicle, (b) assigning a cost to each node in the first set of nodes, (c) selecting a lowest cost node from the first set of nodes, (d) generating another set of nodes from the selected node, (e) assigning a cost to each of the newly generated nodes, (f) selecting a lowest cost node from all of the nodes, and (g) repeating steps (d)-(f) until a lowest cost node is located at the destination location.. ... Ohio State Innovation Foundation

02/22/18 / #20180049991

Oligonucleotide lipid nanoparticle compositions, methods of making and methods of using the same

Methods for inhibiting oligonucleotide activity in vitro or in vivo to a cell that are formulated with at least one oligonucleotide encapsulated in a lipid nanoparticle are disclosed.. . ... Ohio State Innovation Foundation

02/08/18 / #20180037882

Galvanotaxis assay for quantitative assessment of metastatic potential of cancer cells

A system for accelerating and/or inhibiting the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of cells without the need for chemokines or glucose. The present invention can also be used to study and quantify the metastatic potential of different cell lines.. ... Ohio State Innovation Foundation

02/08/18 / #20180037663

Methods and compositions related to single chain antibody fragments that bind to tumor-associated glycoprotein 72 (tag-72)

Disclosed herein are methods and compositions related to single chain antibody fragments which specifically bind sialyl-tn epitope of tumor-associated glycoprotein 72 (tag-72).. . ... Ohio State Innovation Foundation

02/08/18 / #20180036939

Systems and methods for additive manufacturing

Disclosed herein are systems and methods method of additively manufacturing distributed sensors in a structural workpiece. The apparatus includes a movable head having an actuator coupled to an ejection port to regulate dispensation of a first thermoplastic polymer fed from an elongated chamber located in the movable head and coupled to the ejection port, wherein the movable printer head comprises a pair of electrodes proximately positioned relative to the chamber so as to direct an electric field, when the electrodes are energized, thereacross or therethough. ... Ohio State Innovation Foundation

02/01/18 / #20180031872

On-chip optical polarization controller

An example optical polarization controller can include a substantially planar substrate and a waveguide unit cell formed on the substantially planar substrate. The waveguide unit cell can include a first out-of-plane waveguide portion and a second out-of-plane waveguide portion coupled to the first out-of-plane waveguide portion. ... Ohio State Innovation Foundation

02/01/18 / #20180030094

Chemical synthesis and screening of bicyclic peptide libraries

Disclosed herein are bicyclic peptide compounds, compositions comprising same, methods for making same, and libraries comprising same. The disclosed compounds, in various aspects, are useful for treating a variety of disorders, including inflammatory disorders, autoimmune disorders, and disorders of uncontrolled cellular proliferation. ... Ohio State Innovation Foundation

02/01/18 / #20180028642

Chlamydia-activated b cell platforms and methods thereof

Disclosed herein is a chlamydia-activated b cell (cab) platform. Also disclosed is a method of enhancing a population of b cells, comprising exposing said b cells to chlamydia spp. ... Ohio State Innovation Foundation

01/25/18 / #20180021447

Lipid nanoparticle compositions and methods of making and methods of using the same

Lipid nanoparticle formulations, methods of making, and methods of using same are disclosed.. . ... Ohio State Innovation Foundation

12/28/17 / #20170370573

Oxygen carrying materials

In accordance with one embodiment of the present disclosure, an oxygen carrying material may include a primary active mass, a primary support material, and a secondary support material. The oxygen carrying material may include about 20% to about 70% by weight of the primary active mass, the primary active mass including a composition having a metal or metal oxide selected from the group consisting of fe, co, ni, cu, mo, mn, sn, ru, rh, and combinations thereof. ... Ohio State Innovation Foundation

12/28/17 / #20170369664

Functional surfaces and methods of making thereof

Provided herein are methods of making functional surfaces, including liquid repellant surfaces that can exhibit selective wetting properties. Methods of forming a functional surfaces can comprise providing a dispersion of nanoparticles; and applying the dispersion to a polymer surface to form a multiplicity of re-entrant structures embedded within and protruding from the polymer surface. ... Ohio State Innovation Foundation

12/21/17 / #20170361299

Methods and devices for the preparation of nanomaterials

Disclosed herein are methods for preparing nanomaterials, such as nanoparticles. The methods can involve jet-mixing two or more precursor solutions to form the nanomaterials. ... Ohio State Innovation Foundation

12/07/17 / #20170351027

Patterned ion-sliced crystal for hybrid integrated photonics

An example method of forming a deterministic thin film from a crystal substrate is described herein. The method can include implanting ions into a surface of the crystal substrate to form a thin film crystal layer, and bonding the crystal substrate and a handle substrate to form a bilayer bonding interface between the crystal substrate and the handle substrate. ... Ohio State Innovation Foundation

12/07/17 / #20170348409

Compositions and methods related to viral vaccines

Provided herein are methods and compositions relating to infectious bursal disease virus (ibdv), and vaccines for treatment and prevention thereof.. . ... Ohio State Innovation Foundation

11/30/17 / #20170341017

Membranes for fluid separation

Membranes, methods of making the membranes, and methods of using the membranes are described herein. The membranes can comprise a gas permeable support and a continuous phase comprising a selective inorganic material disposed within the gas permeable support. ... Ohio State Innovation Foundation

11/23/17 / #20170335472

Catalytic materials and methods of making and using thereof

Iron-containing mixed-phase metal oxides are described. The mixed-phase metal oxides can exhibit electrocatalytic and/or photo-electrocatalytic activity towards reducing reactions, such as the reduction of carbon dioxide.. ... Ohio State Innovation Foundation

11/23/17 / #20170333493

Probiotic bacteria for the prevention and treatment of salmonella

As disclosed herein, fructose-asparagine (f-asn) is a primary nutrient utilized during salmonella-mediated gastroenteritis. Engineered bacteria are disclosed that can compete with salmonella for f-asn and other nutrients and withstand salmonella-induced inflammation. ... Ohio State Innovation Foundation

11/23/17 / #20170332938

Methods for co-imaging tissue stiffness and blood flow in an mri scan

Techniques for co-imaging tissue stiffness and blood flow using a single mri scan are disclosed. The methods use a combined gradient waveform that provides adequate sensitivity for concurrent encodings of flow and tissue stiffness. ... Ohio State Innovation Foundation

11/23/17 / #20170332937

Hydraulically-powered and hybrid hydraulic-pneumatic systems and methods for achieving magnetic resonance elastography

Systems and methods are described for inducing tissue vibration for magnetic resonance elastography is described. The system includes a hydraulic drive component that is mechanically linked to a pneumatic drive component. ... Ohio State Innovation Foundation

11/16/17 / #20170328904

Tethered lipoplex nanoparticle biochips and methods of use

Disclosed are compositions and methods for the use of lipoplex nanoparticle chips and arrays in the detection of/diagnosis of a disease or condition.. . ... Ohio State Innovation Foundation

11/09/17 / #20170323460

Image color data normalization and color matching system for translucent material

A shade selection program is disclosed that predicts the shade choice with the smallest ciede2000 color difference for dental composite resin restorations when given a backing and target shade. By utilizing generated regression models, a database of spectral reflectance information, and principles of kubelka-munk layering, a highly accurate shade selection program was designed. ... Ohio State Innovation Foundation

11/09/17 / #20170320941

Cs1-specific chimeric antigen receptor engineered immune effector cells

Disclosed herein are chimeric antigen receptors (car) that can specifically recognize tumor-associated antigens (taa) on multiple myeloma (mm) cells. Also disclosed are immune effector cells, such as t cells or natural killer (nk) cells, that are engineered to express these cars. ... Ohio State Innovation Foundation

10/26/17 / #20170308782

Stretchable broad impedance bandwidth rfid devices

According to the embodiments described herein, a stretchable rfid device can include an rfid chip and an rfid antenna. The rfid antenna can be electrically coupled and mechanically attached to the rfid chip. ... Ohio State Innovation Foundation

10/26/17 / #20170307955

Devices and methods for implementing an optical switching engine

Disclosed herein are various improvements in optical switching engines. In one aspect, a range of switching engines includes various multiple bounce, multiple image devices, such as, for example, the herriott cell and the robert cell. ... Ohio State Innovation Foundation

10/26/17 / #20170306337

Bioproduct formation from a plasmid addiction system in the absence of co-inducers and antibiotics

Described herein are plasmid addiction systems comprising a host cell comprising one or more inactivated host cell essential genes; and a plasmid comprising one or more plasmid essential genes operably linked to a constitutively active promoter. Also described herein are metabolism-based plasmid addiction systems (pas) comprising a host cell and a plasmid operably linked to a constitutively active promoter for producing value-based products (e.g., 1-butanol) and methods of generating pass in microorganisms and producing 1-butanol from a pas in the absence of antibiotics and/or co-inducers.. ... Ohio State Innovation Foundation

10/26/17 / #20170305959

Antileishmanial compositions and methods of use

In one aspect, the invention relates methods and compositions for treating parasitic diseases, for example, leishmaniasis. In a further aspect, the compounds of the methods and compositions are isolated from pentalinon andrieuxii. ... Ohio State Innovation Foundation

10/26/17 / #20170304571

Intubation with audiovibratory guidance

Systems and methods are provided for inserting an endoscope through an anatomical cavity to a target site. A speaker is positioned externally proximate to a patient and the endoscope is inserted into the anatomical cavity. ... Ohio State Innovation Foundation

10/26/17 / #20170304383

Small molecule ras inhibitors

Disclosed herein are novel compounds that are ras inhibitors. Also disclosed are compositions comprising the compounds and methods of using the compounds in treating various diseases. ... Ohio State Innovation Foundation

10/26/17 / #20170304261

Silvestrol, silvestrol analogs and uses thereof

Disclosed herein are treatment methods, vaccination methods, compositions, co-therapeutic methods, combination therapeutic compositions and kits comprising silvestrol and silvestrol analogs alone or in combination with therapeutic and preventative therapies. Disclosed herein are also methods, compositions and kits that can be used to treat cancer, viral infections, to modulate the immune system or as preventative therapies.. ... Ohio State Innovation Foundation

10/12/17 / #20170291253

Hybrid structures for joining of metals and continuous fiber materials

A transition structure includes a metallic portion, a fiber portion including a plurality of tows embedded within the metallic portion and extending out from the metallic portion forming a fabric, and a binding material forming a matrix surrounding the fiber portion embedded within the metallic portion. The fiber portion may be attached to or form part of a composite vehicle component. ... Ohio State Innovation Foundation

10/05/17 / #20170281740

Serodiagnosis of salmon poisoning disease

Neorickettsia helminthoeca is an obligate intra-cytoplasmic bacterium that causes salmon poisoning disease (spd), an acute, febrile, fatal disease of dogs. Disclosed are compositions and methods for the immunodetection of n. ... Ohio State Innovation Foundation

10/05/17 / #20170281723

Improved peptidyl calcineurin inhibitors

Improved calcineurin inhibitors and methods of using these improved calcineurin inhibitors to inhibit calcineurin-nfat signaling in cells and in subjects are disclosed.. . ... Ohio State Innovation Foundation

09/28/17 / #20170273608

Ionic barrier for floating gate in vivo biosensors

An ion-sensitive sensor includes a dielectric layer comprising al2o3 having a functionalized surface configured to bond with an analyte. The ion-sensitive sensor is immersed in an electrolytic solution containing a concentration of alkali ions. ... Ohio State Innovation Foundation

09/21/17 / #20170272158

Driver system with an optical power based isolated power supply

The present invention relates to a driver system that can include an optical power based isolated power supply. The driver system can include an optical receiver that can be in communication with an optical transmitter to receive an optical signal. ... Ohio State Innovation Foundation

09/21/17 / #20170269188

Folded transducer array for compact and deployable wave-energy guiding system

A wave energy guiding system is described that includes a structural substrate formed according to a folded-pattern topology including, for example, an origami-type folded-pattern topology such as miura-ori. The structural substrate includes a plurality of planar facets each positionable at an angle relative to adjacent planar facets. ... Ohio State Innovation Foundation

09/21/17 / #20170268591

Designs and manufacturing methods for lightweight hyperdamping materials providing large attenuation of broadband-frequency structure-borne sound

A hyperdamping inclusion under constraint with large, broadband frequency damping properties is disclosed. The inclusion includes materials under near-buckling constraint such that fundamental eigenfrequency vanishes at near-buckling.. ... Ohio State Innovation Foundation

08/24/17 / #20170241817

Velocity vector field mapping using electrical capacitance sensors

The present invention provides a system and method for velocity vector field calculation at the voxel level of a multi-phase flow system using electrical capacitance volume tomography sensors.. . ... Ohio State Innovation Foundation

08/17/17 / #20170232501

Hot forming of cooling galleries in steel pistons

A piston, particularly a piston for use in a diesel engine, particularly a heavy duty diesel engine, is formed from a billet of metal, such that the finished piston has a mass that is at least 50%, and, more preferably, up to about 62%, of the mass of the billet. Other than finishing steps, the piston is formed with a closed gallery, without loss of mass through machining processes.. ... Ohio State Innovation Foundation

08/10/17 / #20170224833

Self-assembling molecules that accumulate in acidic tumor microenvironments

Disclosed are compositions that contain a plurality of biocompatible self-assembling molecules that transform from isolated molecules or spherical micelles while in blood serum into cylindrical nanofibers in the acidic extracellular environment of tumors, which can be used to achieve a higher relative concentration of imaging drug delivery, or radiotherapeutic agents at the tumor site compared to non-tumor tissues. This transition is rapid and reversible, indicating the system is in thermodynamic equilibrium.. ... Ohio State Innovation Foundation

08/10/17 / #20170224259

Magnetic resonance imaging method to non-invasively measure blood oxygen saturation

Methods for data acquisition and processing of magnetic resonance (mr) imaging to obtain the oxygen saturation (o2sat) of blood using a relationship between transverse relaxation time (t2) of blood and oxygen saturation. The method includes obtaining multiple images at various t2 preparation times. ... Ohio State Innovation Foundation

08/03/17 / #20170218081

Methods and compositions related to antibody fragments that bind to tumor-associated glycoprotein 72 (tag-72)

Disclosed herein are methods and compositions related to antibody fragments which specifically bind sialyl-tn epitope of tumor-associated glycoprotein 72 (tag-72).. . ... Ohio State Innovation Foundation

08/03/17 / #20170216458

Intrathecal delivery of recombinant adeno-associated virus 9

The present invention relates to adeno-associated virus type 9 methods and materials useful for intrathecal delivery of polynucleotides. Use of the methods and materials is indicated, for example, for treatment of lower motor neuron diseases such as sma and als as well as pompe disease and lysosomal storage disorders. ... Ohio State Innovation Foundation

07/27/17 / #20170209838

Composite membranes for separation of gases

Membranes, methods of making the membranes, and methods of using the membranes are described herein. The membranes can comprise a gas permeable support layer, an inorganic layer disposed on the support, the inorganic layer comprising a plurality of discreet nanoparticles having an average particle size of less than 1 micron, and a selective polymer layer disposed on the inorganic layer, the selective polymer layer comprising a selective polymer having a co2:n2 selectivity of at least 10 at 57° c. ... Ohio State Innovation Foundation

07/27/17 / #20170209504

Probiotic formulations and methods for use

Provided herein are compositions comprising a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.. ... Ohio State Innovation Foundation

07/13/17 / #20170200906

Germanane analogs and optoelectronic devices using the same

The present invention provides novel two-dimensional van der waals materials and stacks of those materials. Also provided are methods of making and using such materials.. ... Ohio State Innovation Foundation

07/06/17 / #20170196074

Liquid thin-film laser target

Described in this disclosure is a laser target comprised of a liquid film creation device that is configured to form a liquid laser target. Methods of forming a liquid thin-film laser target are also described.. ... Ohio State Innovation Foundation

06/08/17 / #20170157397

Devices, systems, and methods for treating obstetric and gynecological disorders

One aspect of the present disclosure relates to a therapy delivery device for treating an obstetric or gynecological disorder other than urinary incontinence in a subject. The therapy delivery device can include a housing, at least one electrode, and a power source. ... Ohio State Innovation Foundation

05/11/17 / #20170131267

Devices and methods for the rapid and accurate detection of analytes

Disclosed are field effect transistor-based (fet-based) sensors for the rapid and accurate detection of analytes both in vivo and in vitro. The fet-based sensors can include a substrate, a channel disposed on the substrate, a source electrode and a drain electrode electrically connected to the channel, and a recognition element for an analyte of interest immobilized on the surface of the channel via a linking group. ... Ohio State Innovation Foundation

05/11/17 / #20170130752

Welding methods and welded joints for joining high-strength aluminum alloys

Welding methods and welded joints for improving corrosion resistance of the joint between a plurality of high-strength aluminum alloy structural members are described herein. An example method can include applying a first weld at a junction between the plurality of high-strength aluminum alloy structural members using a first filler metal, and applying a second weld on at least a portion of a toe of the first weld using a second filler metal. ... Ohio State Innovation Foundation

05/04/17 / #20170120055

Systems and methods for treating autonomic instability and medical conditions associated therewith

One aspect of the present disclosure relates to a closed-loop therapy system for treating autonomic instability or a medical condition associated therewith in a subject. The therapy delivery system can include a sensing component, a delivery component, and a controller. ... Ohio State Innovation Foundation

05/04/17 / #20170120046

Systems and methods of improving an inflammatory disorder

Methods for improving an inflammatory disorder in a subject are provided. Methods include positioning a therapy delivery device on a neural target site that contributes to immune activity of the subject. ... Ohio State Innovation Foundation

05/04/17 / #20170119806

Arylnaphthalene lactone derivatives and methods of making and using thereof

A series of natural products including phyllanthusum, an arylnaphthalene lignan derivative, with anticancer and antitumor and immunostimulating activity are disclosed. The invention further encompasses methods of adding water solubilizing groups to the arylrings that include phosphonyl groups.. ... Ohio State Innovation Foundation

04/27/17 / #20170115244

Thermal simulator

A thermal simulator simulates the thermal behavior of items such as eggs for which the actual internal temperature profile is difficult to measure. A yolk body simulates the egg yolk, an albumen body surrounds the yolk body and simulates the egg albumen, and a shell layer surrounds the albumen body to simulate the shell. ... Ohio State Innovation Foundation

04/27/17 / #20170112896

Small molecule rac or rho inhibitors

Disclosed herein are methods of inhibiting rac or rho in a cell or tissue or for treating a disease mediated at least in part by rac or rho, using a compound of the formula:. . ... Ohio State Innovation Foundation

04/13/17 / #20170103528

Volumetric texture score

During lts calculations, first gray level transformations are applied to dicom images, followed by two-point correlation function based threshold calculations being applied to each pixel (voxel) in the given volume. Finally these calculations lead into estimation of textures within the given volume (lts). ... Ohio State Innovation Foundation

04/13/17 / #20170101681

Mirna biomarkers for monitoring bone marrow reconstitution

Disclosed herein are compositions and methods for monitoring hematopoietic reconstitution or suppression in a subject. Also disclosed are compositions and methods for reconstituting the hematopoietic compartment of a subject in need thereof. ... Ohio State Innovation Foundation

04/13/17 / #20170100605

Systems and methods of improving an immune disorder

Methods for improving an immune disorder in a subject are provided. The immune disorder can be an autoimmune disorder, a hypersensitivity syndrome, or an immune deficiency syndrome. ... Ohio State Innovation Foundation

04/13/17 / #20170100604

Systems and methods of improving metabolic syndrome

Methods for improving metabolic syndrome in a subject are provided. Methods include positioning a therapy delivery device on a neural target site that contributes to immune activity of the subject. ... Ohio State Innovation Foundation

04/13/17 / #20170100589

Systems and methods of improving infections by neuromodulation of immune function

Methods for improving infection in a subject are provided. Methods include positioning a therapy delivery device on a neural target site that contributes to immune activity of the subject. ... Ohio State Innovation Foundation

04/13/17 / #20170100588

Systems and methods of improving cancer symptoms by neuromodulation of immune function

Methods for improving cancer symptoms in a subject are provided. Methods include positioning a therapy delivery device on a neural target site that contributes to immune activity of the subject. ... Ohio State Innovation Foundation

03/30/17 / #20170087530

Methods for producing nanoparticles and using same

A method for producing nanocomposite particles is provided. The method comprises supplying an organic phase fluid an organic phase fluid, an aqueous phase fluid, an amphiphile, and a plurality of hydrophobic nanospecies to a nozzle. ... Ohio State Innovation Foundation

03/23/17 / #20170082868

Contact lens comprising lenticular-like curve

Disclosed herein is a contact lens comprising a rounded, minus-carrier, lenticular-like curve over a central, upper portion of the lens that allows the contact lens to translate upwards in downgaze.. . ... Ohio State Innovation Foundation

03/23/17 / #20170080081

Paramyxovirus immunogens and related materials and methods

Described herein are methyltransferase (mtase)-defective recombinant viruses as vaccines for human metapneumovirus (hmpv), human respiratory syncytial virus (hrsv), and human parainfluenza virus type 3 (piv3); as well as related materials and methods.. . ... Ohio State Innovation Foundation

03/23/17 / #20170080078

Compositions and methods for treating and preventing porcine reproductive and respiratory syndrome

Disclosed herein are methods and compositions for treating or preventing porcine reproductive and respiratory syndrome (prrs) infection in a subject.. . ... Ohio State Innovation Foundation

03/16/17 / #20170072041

Ehrlichial invasin for immuniztion, diagnosis, and cell delivery

Disclosed are vaccines containing one or more immunogenic polypeptides derived from an etpe protein from an ehrlichia sp. Or nucleic acid encoding these polypeptides. ... Ohio State Innovation Foundation

03/02/17 / #20170056839

Membranes for gas separation

Membranes, methods of making the membranes, and methods of using the membranes are described. The membranes can comprise a support layer, and a selective polymer layer disposed on the support layer. ... Ohio State Innovation Foundation

03/02/17 / #20170056834

Multilayer coatings and methods of making and using thereof

Multilayer coatings, articles comprising multilayer coatings, and methods of making and using thereof are described herein. The multilayer coating can contain two or more oppositely charged alternating layers, comprising at least one fixed layer comprising a first polymer and at least one inorganic layer comprising a plurality of particles, wherein the inorganic layer forms a surface of the two or more oppositely charged alternating layers. ... Ohio State Innovation Foundation

03/02/17 / #20170056346

Methods and compositions for treating multiple myeloma

Methods and compositions for sensitizing multiple myeloma cells to treatment with imids are provided. Aspects include methods of administering ar-42 and an imid (e.g., lenalidomide, pomalidomide) to multiple myeloma patients.. ... Ohio State Innovation Foundation

02/23/17 / #20170051005

Primers and methods for nucleic acid amplification

A primer and method for amplification of a target nucleic acid, the primer adapted to conform into a conformation that dissociates from a complementary strand of dna duplex. The conformation may have a free energy with more favorable thermodynamics than a corresponding dna duplex, such as a b-dna duplex. ... Ohio State Innovation Foundation

02/02/17 / #20170033187

Enhancement mode field effect transistor with doped buffer and drain field plate

This disclosure relates to a novel approach towards enhancing the threshold voltage of an enhancement-mode field-effect-transistor (e-mode fet) using doped or polarization-graded buffer layers and utilizing drain-connected field plates to engineer peak fields. Enhancement-mode field effect transistors (e-mode fets) with doped buffer layers replacing conventional undoped buffer layers could enable larger threshold voltages, owing to higher capacitance from the back. ... Ohio State Innovation Foundation

02/02/17 / #20170029589

Polymer foam and method for preparing the same

Polymer foam and a method for preparing the same are disclosed. In the present disclosure, the method sequentially comprises the following steps: providing a polymer body; performing a pressure-induced flow (pif) process on the polymer body at a first predetermined temperature and a first predetermined pressure for a pressure holding time, to obtain a polymer sheet; and performing a foaming process on the polymer sheet by using a foaming agent at a second predetermined temperature and a second predetermined pressure for a saturation time, to obtain polymer foam.. ... Ohio State Innovation Foundation

01/26/17 / #20170024024

Systems and methods for three dimensional control of mobile applications

The embodiments described herein relate to systems, methods, and devices for capturing arm motion. The arm motion can be transformed into a rendered object that can interact with a three dimensional scene that allows a user to intuitively grab, move, manipulate and hit objects within the scene.. ... Ohio State Innovation Foundation

01/26/17 / #20170020846

Compositions and methods for inhibiting the growth of multi-drug resistant microbes

Compositions and methods for preventing and treating infection with multi-drug resistant bacteria with ar-13 alone or in combination with antibiotics are provided.. . ... Ohio State Innovation Foundation

01/19/17 / #20170018843

Stretchable and flexible electronics and methods of making and using the same

A method of making a stretchable and flexible electronic device includes the steps of creating a computer aided design using a computer modeling software system of the electronic device; digitizing the computer aided design and importing the design into a computer memory of a sewing machine capable of performing embroidery; using the sewing machine and a conductive thread to embroider the design on to a fabric substrate to create the electronic device, whereby the electronic device comprises at least a portion of conductive threads; removing the fabric substrate from the electronic device using heat; coating the electronic device with a polymer.. . ... Ohio State Innovation Foundation

01/05/17 / #20170002353

Methods and compositions related to mir-21 and mir-29a, exosome inhibition and cancer metastasis

The present invention provides materials and methods related to the discovery that tumor secreted mir-21 and mir-29a can function by binding as ligands to receptors of the toll-like receptor family, murine tlr7 and human tlr8, in immune cells, triggering a tlr-mediated prometastatic inflammatory response, which leads to tumor growth and metastasis. Thus, by acting as paracrine agonists of tlrs, secreted mirnas are key regulators of the tumor microenvironment. ... Ohio State Innovation Foundation

01/05/17 / #20170000169

Colorant compositions and methods of use thereof

Natural blue colorant compositions and methods of use thereof are provided. The colorant compositions include at least one acylated anthocyanin, such as a diacylated anthocyanin. ... Ohio State Innovation Foundation








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