Oncomed Pharmaceuticals Inc patents (2018 archive)

Combination therapy for treatment of disease

The present invention provides methods comprising combination therapy for modulating immune responses, for inhibiting tumor growth, and/or for treating cancer. In particular, the present invention provides notch pathway inhibitors in combination with immunotherapeutic agents for the treatment of cancer and other diseases.. ... Oncomed Pharmaceuticals Inc

Compositions and methods for diagnosing and treating cancer

An isolated antibody that specifically binds to an extracellular domain of two or more human fzd receptors and inhibits growth of tumor cells is described. Also described is a method of treating cancer comprising administering an antibody of the present disclosure in an amount effective to inhibit tumor cell growth.. ... Oncomed Pharmaceuticals Inc

Lymphotoxin-beta receptor-binding agents, targeting antibodies, and uses thereof

Polypeptides, agents, and molecules that bind lymphotoxin-beta receptor (ltβr) and/or tumor-associated antigens are disclosed. The polypeptides, agents, or molecules may include, without limitation, fusion or single-chain lymphotoxin-αββ polypeptides and homodimer and heterodimer molecules comprising the lymphotoxin-αββ polypeptides. ... Oncomed Pharmaceuticals Inc

Immunotherapy with binding agents

Binding agents that modulate the immune response are disclosed. The binding agents may include soluble receptors, polypeptides, and/or antibodies. ... Oncomed Pharmaceuticals Inc

Compositions and methods for treating and diagnosing cancer

The present invention relates to compositions and methods for characterizing, diagnosing and 2treating cancer. In particular, the present invention identifies lgr5 as a protein over-expressed in solid tumor stem cell. ... Oncomed Pharmaceuticals Inc

Compositions and methods for diagnosing and treating cancer

The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. ... Oncomed Pharmaceuticals Inc

Tnfrsf-binding agents and uses thereof

Polypeptides and agents that bind a tnf receptor superfamily protein are disclosed, particularly agents that specifically bind gitr, ox40, or cd40. The polypeptides or agents may include fusion polypeptides, particularly polypeptides comprising gitrl, ox40l, or cd40l and/or bispecific agents. ... Oncomed Pharmaceuticals Inc