Onyx Therapeutics Inc patents

Compounds for proteasome enzyme inhibition

Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of n-terminal nucleophile (ntn) hydrolases. The activities of those ntn having multiple activities can be differentially inhibited by the compounds described. ... Onyx Therapeutics Inc

Prodrugs of peptide epoxy ketone protease inhibitors

This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.. . ... Onyx Therapeutics Inc

Compunds for enzyme inhibition

Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of n-terminal nucleophile (ntn) hydrolases associated with the proteasome. The peptide-based compounds include an epoxide or aziridine, and functionalization at the n-terminus. ... Onyx Therapeutics Inc

Combination therapy with peptide epoxyketones

The invention provides combination therapy, wherein one or more other therapeutic agents are administered agents are administered with peptide epoxyketones or a pharmaceutically acceptable salt thereof. Another aspect of the invention relates to treating cancer with a peptide epoxyketone administered in combination with another therapeutic agent.. ... Onyx Therapeutics Inc