Heteroaryl carbonitriles for the treatment of disease
. . The invention relates to pharmaceutical compositions and dosage forms having a piperidine carbonitrile as an active ingredient for the treatment of various diseases and conditions. The preferred compound is a crystalline form of a trifluoromethylphenylalkoxyalkylheteroarylaryl piperidine carbonitrile. ... Opko Health Inc
. . . . This application discloses a process to synthesize 8-({1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy)-methyl]-8-pheny-1,7-diazaspiro[4.5]decan-2-one comprising reacting a compound of the formula 27a-sulfonate with zinc in the presence of acetic acid.. . ... Opko Health Inc