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Osaka University patents


Recent patent applications related to Osaka University. Osaka University is listed as an Agent/Assignee. Note: Osaka University may have other listings under different names/spellings. We're not affiliated with Osaka University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "O" | Osaka University-related inventors


Fluorescent protein

A photo-switching fluorescent protein of a type in which wavelengths for switching fluorescence on and off and wavelength for fluorescence excitation are all independent of one another is provided, which has an amino acid sequence in which at least an s208g mutation is introduced into seq id no: 1. The fluorescent protein may have an amino acid sequence in which at least three mutations, i47v, m153t, and s208g, are introduced into seq id no: 1. ... Osaka University

Biological information measurement apparatus and biological information measurement method

A biological information measurement apparatus includes: a pressure sensor including a pressure detecting element; a pressing mechanism which presses the pressure sensor against an artery in a living body; a press controller which controls a pressing force of the pressing mechanism; a blood flow sensor; a blood flow information measurer which measures blood flow information based on output of the blood flow sensor; a pressing force decider which decides a first pressing force based on blood flow information measured during a pressing force control time period when the pressing force is changed in one direction, and information of a pressure pulse wave detected during the pressing force control time period; and a record controller which records a pressure pulse wave detected in a first state where the pressing force is controlled to the first pressing force, and blood flow information measured in the first state.. . ... Osaka University

Nuclear spin polarization enhancing method through dynamic nuclear polarization by using soluble pentacene

An object is to provide a method for enhancing a nuclear spin polarization. Triplet dnp where a pentacene derivative represented by the following formula (a) is used as a polarizing agent enables an effective enhancement in nuclear spin polarization to be achieved. ... Osaka University

Electro-optic probe, electromagnetic wave measuring apparatus, and electromagnetic wave measuring method

Provided is an electro-optic probe for detecting an electromagnetic wave, including: an electro-optic crystal; and an optical fiber optically coupled to the electro-optic crystal, wherein a direction of a unique axis of the electro-optic crystal and a polarization direction of light from the optical fiber that enters the electro-optic crystal are set to be in line with each other, or wherein a direction of a unique axis of the electro-optic crystal and a unique polarization direction of the optical fiber are set to be in line with each other.. . ... Osaka University

Optical waveguide forming method and apparatus

An optical waveguide is formed using a gas-enclosed vessel that has an internal space in which a polyvalent ionizable gas is enclosed, a laser beam irradiation unit, and a discharge circuit that causes a pulse current to flow in the gas-enclosed vessel at an initial current value. The pulse current is increased from the initial current value to a subsequent current value greater than the initial current value, and a polyvalent ionization channel is formed in the internal space, while increasing the pulse current, by irradiating the internal space in the plasma state with a trigger laser beam generated by the pulse laser beam irradiation device. ... Osaka University

Method for bonding metal and resin and metal resin bonded body

A direct bonding method of metal and resin comprises a first step where the metal material is subjected to electrolytic treatment by using a carboxylic acid to form a new surface, which is then coated with the carboxylic acid to obtain a carboxylic acid-coated metal material; a second step where the resin material and the carboxylic acid-coated metal material are laminated to form an interface to be bonded; a third step where the interface is heated to tg of the resin material or higher by heating means to remove water from the interface, the decomposition of the resin material generates a carboxyl group, and the new surface is exposed on the surface of the carboxylic acid-coated metal material by removal of the carboxylic acid; and a fourth step where the interface is cooled below the tg to form a bonded part by bonding the carboxyl group and the new surface.. . ... Osaka University

Method for determining leg-phase shift timing, leg-phase shift timing determination apparatus, method for controlling walking assistance, and walking assistance apparatus

A walking assistance apparatus includes: a walking assistance attachment to be attached to a leg of a human body and including a variable stiffness mechanism having stiffness that is changeable in a direction where the human bends and stretches the knee by motor driving; and a controller. The controller includes a foot-end motion calculation part configured to receive an output from a sensor to detect motion of a leg and successively calculate a relative velocity of a foot end with reference to a waist of the human body; and a leg state determination part configured to determine shift timing between a swing phase and a stance phase based on the relative velocity of the foot end.. ... Osaka University

Oral cancer vaccine

A cancer vaccine that can be orally administered can be provided through the use of a transformed bifidobacterium capable of expressing and displaying a wt1 protein. The wt1 protein expressed and displayed by the transformed bifidobacterium is a protein covering most of a wt1 protein unlike a wt1 peptide vaccine restricted to a certain hla. ... Osaka University

Reflective structure, device, and method for producing reflective structure

A liquid crystal element (1) includes helical structures (7). The liquid crystal element (1) has a light incidence surface (13) on which light is incident and a reflective surface (17) which reflects the light coming through the light incidence surface (13). ... Osaka University

Method for cryopreservation of cardiocytes derived from pluripotent stem cells or mesenchymal stem cells derived from adipose tissue or bone marrow

A method is disclosed for cryopreservation of cardiocytes derived from pluripotent stem cells or mesenchymal stem cells derived from adipose tissue or bone marrow, the method maintaining the function of the cardiocytes derived from differentiated pluripotent stem cells or mesenchymal stem cells derived from adipose tissue or bone marrow, and yet reducing the possibility for tumorigenesis of undifferentiated pluripotent stem cells or mesenchymal stem cells derived from adipose tissue or bone marrow. A method is also disclosed for cryopreservation of cardiocytes derived from pluripotent stem cells or mesenchymal stem cells (derived from adipose tissue or bone marrow, the method including dissociating cells from a cell population which has been induced to differentiate into cardiocytes from pluripotent stem cells or mesenchymal stem cells derived from adipose tissue or bone marrow.. ... Osaka University

Corneal epithelioid cells derived from surface ectodermal cells

The present invention relates to a method for inducing a keratin 12-positive corneal epithelioid cell from a surface ectoderm-derived cell. More specifically, the present invention relates to a method for inducing a keratin 12-positive corneal epithelioid cell, comprising introducing pax6, klf4, and oct4 into a surface ectoderm-derived cell, such as an oral mucosal epithelial cell, and a corneal epithelioid cell induced by the method.. ... Osaka University

Oligopeptide having proinflammatory cytokine secretion-inhibiting activity

Provided is an oligopeptide having preventive and therapeutic effects on infarction diseases. The oligopeptide contains a de loop sequence of rankl protein, and has inhibitory activity on proinflammatory cytokine secretion from cells.. ... Osaka University

Virtual network control apparatus, virtual network control method, and program

A virtual network control apparatus configured to perform assignment of physical resources under management for a virtual network embedding request, including: a physical network resource management agent configured to manage use state of resources on a physical network at each future time; and a virtual network control agent, the virtual network control agent including: demand prediction means configured to perform prediction of future demand for a virtual network; and use resource determination means configured to calculate physical resources to be used at each future time by the virtual network based on a prediction result of the demand obtained by the demand prediction means and information of future use state of resources on the physical network obtained from the physical network resource management agent, and to notify the physical network resource management agent of information of physical resources of the calculation result.. . ... Osaka University

Core-shell catalyst and reaction acceleration method

Provided are (i) a catalyst that has a core-shell structure and is highly active in an oxygen reduction reaction, which is a cathode reaction of a fuel cell, and (ii) a reaction acceleration method in which the catalyst is used. A core-shell catalyst for accelerating an oxygen reduction reaction, contains: silver or palladium as a core material; and platinum as a shell material, the core-shell catalyst having, on a surface thereof, a (110) surface of a face centered cubic lattice.. ... Osaka University

05/17/18 / #20180133986

Self-repairing material and manufacturing method therefor

The present invention provides a self-repairing material having self-repairing properties and shape memory properties, as well as high dynamic strength, and also provides a method for manufacturing the same. The self-repairing material of the present invention comprises a polymer comprising specific monomer units in specific ratios, and the concentration of the monomer units is within a specific range.. ... Osaka University

05/03/18 / #20180120299

Tim protein-bound carrier, methods for obtaining, removing and detecting extracellular membrane vesicles and viruses using said carrier, and kit including said carrier

The invention provides a carrier and a method for obtaining, removing, or detecting extracellular membrane vesicle or virus present in a sample. In particular, the invention provides (a) a carrier (a tim carrier) on which a protein (a tim protein), selected from a t-cell immunoglobulin and mucin domain-containing molecule-4 (a tim-4) protein, a tim-3 protein, and a tim-1 protein, is bound; (b) a method for obtaining the extracellular membrane vesicle or the virus in the sample; (c) a method for removing the extracellular membrane vesicle or the virus in the sample; (d) a method for detecting the extracellular membrane vesicle or the virus in the sample; (e) a kit for capturing the extracellular membrane vesicle or the virus, comprising the tim carrier; and f) a kit for capturing the extracellular membrane vesicle or the virus, comprising a reagent containing the tim protein and a reagent containing the carrier.. ... Osaka University

04/19/18 / #20180104747

Method for producing copper particles, copper particles, and copper paste

A method for producing copper particles includes a preparation step and a heating step. In the preparation step, a copper compound, a salt of a main group metal, and a polyhydric alcohol are prepared. ... Osaka University

04/05/18 / #20180093725

Legged mechanism, walking robot, method for controlling posture, and recording medium

A walking robot (1) includes a body (20) joined with an upper part of two legs (10) so that the body has a changeable posture relative to the legs; and a posture control unit (105, 106, 107) configured to control a posture of the body stably in accordance with states of the legs (10) and the body (20). The walking robot includes: a state calculation unit (101, 102, 103) configured to calculate periodically, from angular information on the legs (10) and the body (20), angular momentum p1 around a lower end of the leg in a stance phase and integral pi1 of the angular momentum; and a stabilization determination unit (104) configured to determine whether the calculated angular momentum p1 and integral pi1 are approaching or getting away from target values, and output a result of the determination to the posture control unit (105, 106, 107).. ... Osaka University

03/22/18 / #20180081202

Optical quantizer

An optical quantizer including: a first shaping unit which performs at least intensity modulation of the sampling optical pulses using an analog signal to generate first optical pulses having a spectrum in which intensity is flat in a spectrum axis direction; a second shaping unit which performs spectrum shaping of the sampling optical pulses to generate second optical pulses having a spectrum in which intensity increases or decreases monotonously in the spectrum axis direction; a phase shifter which shifts a phase of optical pulses input to one of the first shaping unit and the second shaping unit so that a phase difference between the first optical pulses and the second optical pulses becomes a predetermined phase difference; an interference device which causes interference between the first optical pulses and the second optical pulses; and a wavelength demultiplexer which demultiplexes optical pulses output from the interference device into light of wavebands.. . ... Osaka University

03/22/18 / #20180078184

Dual-task performing ability evaluation method and dual-task performing ability evaluation system

A dual-task performing ability evaluation method includes a dual task step (s201), an analysis step (s401), and an evaluation step (s601). In the dual task step (s201), a subject performs a dual task including a movement task that requires the subject to perform specific movement and an intelligence task that requires the subject to answer a specific problem. ... Osaka University

03/15/18 / #20180073926

Light wavelength measurement method and light wavelength measurement apparatus

A light wavelength measurement method of measuring a wavelength of target light includes: receiving target light on a second dispersion device that disperses the target light into a plurality of second beams which reach a plurality of positions corresponding to the wavelength of the target light; and measuring the wavelength of the target light, by using the plurality of the second beams as a vernier scale for measuring the wavelength of the target light within a wavelength range specified by a main scale.. . ... Osaka University

03/15/18 / #20180073024

Chimeric double-stranded nucleic acid

A method of reducing the level of a transcription product in a cell comprising contacting with the cell a composition comprising a double-stranded nucleic acid complex comprising a first nucleic acid strand annealed to a second nucleic acid strand, wherein: (i) the first nucleic acid strand hybridizes to the transcription product and comprises (a) a region consisting of at least 4 consecutive nucleotides that are recognized by rnase h when the strand is hybridized to the transcription product, (b) one or more nucleotide analogs located on 5′ terminal side of the region, (c) one or more nucleotide analogs located on 3′ terminal side of the region and (d) a total number of nucleotides and nucleotide analogs ranging from 8 to 35 nucleotides and (ii) the second nucleic acid strand comprises (a) nucleotides and optionally nucleotide analogs and (b) at least 4 consecutive rna nucleotides.. . ... Osaka University

03/15/18 / #20180071545

Coil apparatus for use in transcranial magnetic stimulation apparatus for increasing current generated by induced electric field

A coil apparatus for use in a transcranial magnetic stimulation apparatus is provided in which the coil apparatus includes a coil arranged to oppose a surface of a head of a human to generate a current by an induced electric field in a magnetic stimulation-target region in a brain by electromagnetic induction, and to stimulate neurons. The coil apparatus includes the coil configured by winding a conductive wire along a predetermined reference surface; and a magnetic body arranged between the head and the coil to oppose the coil, and arranged at a position at an opposite side of the head. ... Osaka University

03/08/18 / #20180067082

Dielectric barrier discharge ionization detector

. . A dielectric barrier discharge ionization detector capable of achieving a high signal-to-noise ratio is provided. The detector includes: a discharging section for generating plasma from argon-containing gas by electric discharge; and a charge-collecting section for ionizing a component in a sample gas by an effect of the plasma and for detecting ion current formed by the ionized component. ... Osaka University

03/08/18 / #20180067079

Dielectric barrier discharge ionization detector

The dielectric barrier discharge ionization detector includes: a dielectric tube through which a plasma generation gas is passed; a high-voltage electrode formed on the outer wall of the dielectric tube; two ground electrodes and formed on the outer wall of the dielectric tube, with the high-voltage electrode in between; a voltage supplier for applying ac voltage between the high-voltage electrode and each ground electrode to generate electric discharge within the dielectric tube and thereby generate plasma from the plasma generation gas; and a charge-collecting section for detecting an ion current formed by ionized sample-component gas produced by the plasma. The distance between one ground electrode and the high-voltage electrode is longer than a discharge initiation distance between these two electrodes, while the distance between the other ground electrode and the high-voltage electrode is shorter than the discharge initiation distance between these two electrodes.. ... Osaka University

03/08/18 / #20180064792

Immunizing peptide, method for producing immunizing peptide, pharmaceutical composition for immune disease containing same, and method for treating immune disease

The present invention provides a novel immunizing peptide that can induce production of an antibody to a complex of the immunizing peptide and an mhc molecule of a living organism the immunizing peptide according to the present invention includes a t-cell epitope and an antibody-inducing portion of a target protein. The antibody-inducing portion is at least one of the following amino acid residues in an amino acid sequence of the target protein: one or more contiguous amino acid residues immediately upstream of a n-terminal amino acid residue of the t-cell epitope; and one or more contiguous amino acid residues immediately downstream of a c-terminal amino acid residue of the t-cell epitope. ... Osaka University

03/01/18 / #20180061954

Semiconductor device and method for manufacturing semiconductor device

A semiconductor device (100) includes a base layer (10), an interface layer (20), and a deposition layer (30). The base layer (10) includes a nitride semiconductor that contains gallium. ... Osaka University

03/01/18 / #20180055886

Method for collecting functional cells in vivo with high efficiency

Biologically low invasive vessels are filled with biological factors that have the activity of mobilizing specific functional cells in the body. The vessels are indwelled in the body. ... Osaka University

02/22/18 / #20180051446

Image display system for work machine, remote operation system for work machine, and work machine

An image display system for a work machine includes an imaging device mounted to a work machine including a working unit having a working implement, an attitude detector detecting an attitude of the working unit, a distance detector determining information about distance to an object to be worked by the work machine, and a processor using information about position of the working implement obtained using an attitude of the working unit, and information about position of the object to be worked obtained from the information about distance from the work machine to an object to be worked, determined by the distance detector, generating an image of a portion corresponding to the working implement, on the object to be worked opposing the working implement, combining the generated image with an image of the object to be worked imaged by the imaging device, and displaying the combined image on a display device.. . ... Osaka University

02/15/18 / #20180042220

Method for cryopreserving sheet-shaped cell culture

Methods are disclosed of freezing, cryopreserving, and transferring a frozen sheet-shaped cell culture. The method of freezing includes (1) a step of immersing in a cryopreservation solution a sheet-shaped cell culture supported by a mesh-shaped support body; (2) a step of removing the cryopreservation solution adhered to the sheet-shaped cell culture, while keeping the sheet-shaped cell culture supported by the mesh-shaped support body; (3) a step of enclosing the sheet-shaped cell culture in a cold-resistant film, an upper surface and a lower surface of the sheet-shaped cell culture being covered by the mesh-shaped support body; and (4) a step of freezing the sheet-shaped cell culture.. ... Osaka University

02/08/18 / #20180037649

Ckap4-molecular-targeted antitumor agent

Disclosed is to identify a target molecule that is involved in dkk1-induced hyperproliferation of tumor cells to provide a novel antitumor agent. Cytoskeleton-associated protein 4 (ckap4) specifically regulates the hyperproliferation effects that are induced by dickkopf-related protein 1 (dkk1), and proliferation of tumor cells can be suppressed by inhibiting expression or function of ckap4 in the tumor cells.. ... Osaka University

02/01/18 / #20180034900

Design apparatus, design method, and recording medium

In cdn, a design apparatus for designing a probability that a delivery server or a delivery route is selected for content delivery in response to a delivery request from a user includes a parameter input unit configured to receive, as input parameter values, a parameter related to the network and an estimated amount of demand for delivery requests, a selection probability design unit configured to design, based on the received input parameter values, a selection probability that a cache server is selected as the delivery server or a selection probability that a delivery route is selected, using model predictive control, so as to reduce an excessive delivery request, which is a rejection of a delivery request, wherein the delivery route is a combination of the delivery server and a delivery path on which the content is delivered by the delivery server, and a selection probability output unit configured to output the selection probability of the cache server or the selection probability of the delivery route.. . ... Osaka University

02/01/18 / #20180031947

Liquid crystal element, deflection element, liquid crystal module, and electronic device

A liquid crystal element includes: a first electrode to which a first voltage is applied; a second electrode to which a second voltage is applied; an insulating layer that is an electrical insulator; a highly resistive layer; a liquid crystal layer containing liquid crystal; a third electrode to which a third voltage is applied; a first boundary layer that is an electrical insulator; and a second boundary layer that faces the first boundary layer with the insulating layer therebetween. The insulating layer is located among the first electrode, the second electrode, and the highly resistive layer, and insulates the first electrode, the second electrode, and the highly resistive layer from one another. ... Osaka University

01/11/18 / #20180010093

Method for inducing differentiation of corneal epithelial cells from pluripotent stem cells

The present invention relates to a method for inducing the differentiation of corneal epithelial cells from pluripotent stem cells. More specifically, the present invention relates to a method for autonomously differentiating pluripotent stem cells, such as human ips cells, into ectodermal cell lineage in a serum-free medium without using feeder cells and inducing the differentiation of the resultant ocular surface ectodermal lineage cells into corneal epithelial cells.. ... Osaka University

01/04/18 / #20180002419

Screening method for pain suppressor and pharmaceutical composition for prevention or treatment of pain

The present invention provides a screening method for a pain suppressor, which method comprises using flrt3 to select a substance capable of inhibiting flrt3 expression or a substance capable of inhibiting flrt3 transport to the spinal cord. In addition, the present invention provides a pharmaceutical composition for prevention or treatment of pain, which pharmaceutical composition comprises, as an active ingredient, a substance capable of inhibiting flrt3 expression or a substance capable of inhibiting flrt3 transport to the spinal cord.. ... Osaka University

12/28/17 / #20170373983

Evaluation device, evaluation method and recording medium

An evaluation device includes a first evaluator configured, for each record used for transmission control of data circulating in a network, to evaluate extent of variation of an amount of the data, based on a history of the amounts of the data matching a condition of the record; a second evaluator configured, for each of the records, to evaluate a size of a space represented by the record, based on the condition of the record; and a calculator configured, for each of the records, to calculate an index value representing a possibility that a predetermined or a greater amount of the data matches the condition of the record within a fixed period of time, based on an evaluation result by the first evaluator, and an evaluation result by the second evaluator. Therefore, it is possible to evaluate a possibility of a sudden occurrence of a flow whose traffic volume is large.. ... Osaka University

12/21/17 / #20170363636

Fluorescent probe, singlet oxygen detection agent, and singlet oxygen detection method

An object of the present invention is to provide a fluorescent probe that easily penetrates a cell and is capable of selectively and efficiently detecting singlet oxygen generated in the cell, a singlet oxygen detection agent containing the fluorescent probe, and a singlet oxygen detection method using the fluorescent probe. The fluorescent probe for detecting singlet oxygen comprises a compound having a silicon-rhodamine skeleton and a skeleton that increases the fluorescence of the fluorescent probe after trapping singlet oxygen to be greater than the fluorescence before trapping singlet oxygen, or a salt, hydrate, or solvate thereof.. ... Osaka University

12/07/17 / #20170350856

Field effect transistor and sensor using same

. . A field effect transistor and a sensor using the field effect transistor is provided. The field effect transistor can be manufactured so as to have uniform properties by simple steps at low costs, and can stably detect, when used as a sensor, a very small amount of analyte with a high sensitivity while the properties are hardly deteriorated. ... Osaka University

12/07/17 / #20170348681

Activation of supported olefin metathesis catalysts by organic reductants

An organic reductant, in particular an organo silicon reductant suitable for activating supported catalysts of the type monem, wherein e is s and/or se, in particular mon, wherein m is w, mo or re, is described as well as its use in metathesis reactions. The reduced catalysts are able to metathesize olefins at low temperatures and are therefore also suitable for metathesis of functionalized olefins.. ... Osaka University

11/23/17 / #20170335284

Differentiation-induced cell population from which undifferentiated cells have been removed, use of same, and method for producing same

Provided is a cell population comprising differentiated cells obtainable by inducing differentiation of pluripotent stem cells, wherein the content ratio of undifferentiated pluripotent stem cells is 0.2% or less.. . ... Osaka University

10/26/17 / #20170306396

Electrodes for biomolecular sequencing device, and biomolecular sequencing device, method, and program

The nano-gap electrode pair 12 is disposed so that a biomolecule joined to at least one or more types of a single molecule included in a sample passes an opposing position, and the strength of the electric field in a position spaced only a predetermined distance on the downstream side from the opposing position 64 becomes stronger than the strength of the electric field in a position spaced only the predetermined distance on the upstream side from the opposing position 64.. . ... Osaka University

10/26/17 / #20170304504

Method for producing the laminate of a sheet-shaped cell culture and fibrin gels

A method for treating a disease associated with tissue abnormality in a subject. The method includes administering an amount of a pharmaceutical composition to a subject in need of treating a disease associated with tissue abnormality, the pharmaceutical composition comprising a laminate comprising a fibrin gel and a cell culture. ... Osaka University

10/05/17 / #20170283778

Artificial peritoneal tissue and method for producing same

The present disclosure relates to: an artificial peritoneal tissue comprising a cellular tissue and a mesothelial cell layer that covers the surface of the cellular tissue, wherein the cellular tissue comprises a fibroblast, an extracellular matrix, and a vascular endothelial cell and/or a lymphatic endothelial cell each capable of forming a lumen; and a method for producing the artificial peritoneal tissue.. . ... Osaka University

10/05/17 / #20170282469

Process for producing surface-modified molded article, and process for producing composite using surface-modified molded article

An object of the present invention is to provide a process for producing a surface-modified molded article, whereby surface layer strength of a molded article can be enhanced, and a molded article containing an organic polymer compound with low adhesive property, such as a fluororesin, can be bonded to an adherend without the use of an adhesive, and whereby a treatment step or an apparatus in an atmospheric-pressure plasma treatment are not complicated, and to provide a process for producing a composite of the surface-modified molded article and an adherend. The present invention is a process for producing a surface-modified molded article wherein a surface of the molded article containing an organic polymer compound is subjected to an atmospheric pressure plasma treatment to introduce a peroxide radical with adjusting the surface temperature of the molded article to (melting point of the organic polymer compound −120° c. ... Osaka University

09/28/17 / #20170275336

Novel peptide and use thereof

An object of the present invention is to provide a novel peptide and a novel immunostimulant or hair grower containing the peptide as an active ingredient. The present invention provides a peptide of 23 or less amino acids comprising the amino acid sequence lhrlkrlrkrl (seq id no: 1), preferably the amino acid sequence lhrlkrlrkrlk (seq id no: 9), and also provides an immunostimulant containing the peptide, a vaccine adjuvant containing the peptide, a vaccine composition containing the peptide, and a hair grower containing the peptide.. ... Osaka University

09/21/17 / #20170270830

Training device and training device system

A stent is formed of a shape-memory alloy and is to be inserted and placed inside a three-dimensional model of a biological organ manufactured for training, under a state in which the stent is mounted on a balloon of a balloon catheter. The stent is expandable under a room temperature environment. ... Osaka University

09/21/17 / #20170268042

Pcr method and pcr kit

Provided are a pcr method and a pcr kit each of which has higher detection accuracy and is more convenient. A pcr method of the present invention subjects a sample to a pcr reaction, the sample containing: a primer set including a first primer and a second primer; a template amplified by the primer set; a first probe which loses at least one bulge structure in a case where a double strand is formed by the first probe and the first primer and which forms the at least one bulge structure by being dissociated from the double strand formed by the first probe and the first primer; and a bulge structure-binding molecule which emits a signal by binding to the at least one bulge structure.. ... Osaka University

09/14/17 / #20170260271

T cell-redirected antigen-binding molecule for cells having immunosuppression function

It was discovered that antigen-binding molecules comprising (i) a domain that binds to a molecule expressed on the surface of cells having immune response-suppressing functions, and (ii) a t cell receptor complex-binding domain exhibit more superior antitumor effects than conventional antigen-binding molecules by crosslinking t cells with cells having immune response-suppressing functions, and damaging the cells having immune response-suppressing functions.. . ... Osaka University

09/14/17 / #20170258875

Agent for preventing or treating demyelinating disease

An object of the present invention is to provide a pharmaceutical preparation that can promote the proliferation of oligodendrocyte precursor cells to effectively prevent or treat a demyelinating disease. Fgf21 acts to promote the proliferation of oligodendrocyte precursor cells, and thus, the administration of fgf21, dna encoding fgf21, an fgf21 production-promoting substance, and/or fgf21-producing cells is effective for preventing or treating a demyelinating disease.. ... Osaka University

09/07/17 / #20170256903

Optical fiber device

In an optical fiber device having a configuration in which an optical fiber is joined to a side surface of another optical fiber, a joint portion is suppressed from reaching a high temperature. The optical fiber device includes a first fluoride fiber, a second fluoride fiber, and a heat dissipation member. ... Osaka University

09/07/17 / #20170253855

Corneal endothelial cell marker

A molecular marker expressed specifically in corneal endothelial cells, and a method for producing one or more corneal endothelial cells using the marker and a method for evaluating one or more corneal endothelial cells using the marker are provided. At least one molecule selected from the group consisting of zp4, mrgprx3, grip1, glp1r, htr1d, and clrn1 is used as a marker specific to corneal endothelial cells.. ... Osaka University

08/31/17 / #20170250458

Terahertz device and terahertz integrated circuit

A thz device includes: an antenna electrode capable of transmitting and receiving a thz wave to free space; first transmission lines capable of transmitting the thz wave, the first transmission lines respectively connected to the antenna electrodes; an active element of which a main electrode is connected to each of the first transmission lines; second transmission lines capable of transmitting the thz wave, the second transmission lines connected to the first active device; pad electrodes respectively connected to the second transmission lines; and a low-pass filter with respect to the thz wave, the low-pass filter connected to the pad electrodes, wherein impedance matching of between the antenna electrode and the active element is performed by an impedance conversion of the first transmission lines. The thz device is capable of the high-efficiency matching between the active element and the antenna due to the impedance conversion effect of the transmission line.. ... Osaka University

08/31/17 / #20170247658

Myocardial cell sheet

A sheet-shaped cell culture is disclosed that includes myocardial cells derived from pluripotent stem cells and has excellent functional properties. A sheet-shaped cell culture obtained by culturing a cell population that includes myocardial cells derived from pluripotent stem cells, wherein the proportion of the number of the myocardial cells derived from pluripotent stem cells to the total number of cells in the cell population is 50% to 70%; a method of producing the sheet-shaped cell culture; a composition including the sheet-shaped cell culture; and a method of treating a disease using the sheet-shaped cell culture or the composition.. ... Osaka University

08/24/17 / #20170242342

Photo-sensitized chemically amplified resist (ps-car) simulation

Methods and systems for ps-car photoresist simulation are described. In an embodiment, a method includes determining by simulation at least one process parameter of a lithography process using a radiation-sensitive material. ... Osaka University

08/17/17 / #20170233533

Self-restoring macromolecular material and production method for same

Provided is a self-restoring macromolecular material that not only has excellent stress relaxation but that can also be easily restored to its original state, even when damaged or severed. Also provided is a method for producing the self-restoring macromolecular material. ... Osaka University

08/17/17 / #20170232390

Dialyzer, liposome producing apparatus, and liposome producing method

A dialyzer (15) includes a hollow fiber dialysis column (20), a liquid tubing section (12a), and a flow rate changing section (16a). The hollow fiber dialysis column (20) includes a hollow fiber membrane, a first flow channel that allows a dialysis target to flow internally of the hollow fiber membrane, and a second flow channel that allows an external liquid to flow externally of the hollow fiber membrane. ... Osaka University

08/03/17 / #20170216288

Immunopotentiator potentiating tumor immunity or infection immunity

. . An object of the present invention is to provide an immunopotentiating agent for reducing tregs (in particular, effector tregs) and potentiating tumor immunity or infection immunity. Imatinib and/or a salt thereof has the action of reducing tregs (in particular, effector tregs) and potentiating tumor immunity or infection immunity, and can be used as an active ingredient for the immunopotentiating agent.. ... Osaka University

07/13/17 / #20170196970

Adjuvant for mucosal vaccine

. . An object of the present invention is to provide an adjuvant for a mucosal vaccine with high safety that induces a sufficient immune response in a mucosal membrane. According to the present invention, an adjuvant for a mucosal vaccine containing a protein complex composed of hemagglutinin (ha) subcomponents ha1 and ha2, and mutant subcomponent ha3 of botulinum toxin is provided.. ... Osaka University

07/06/17 / #20170189873

Thermal convection generating chip and liquid measuring device

A thermal convection generating chip (1) includes a rotatory body (2), a thermal convection pathway (11) provided in the rotatory body (2), and a supply path (12a to 12c) that supplies a liquid to the thermal convection pathway (11). The supply path (12a to 12c) includes a liquid receiving section (121) that receives the liquid and a suction passage (122) that provides communication between the liquid receiving section (121) and the thermal convection pathway (11). ... Osaka University

06/22/17 / #20170176432

Autoantibody detection method, method for testing possibility of autoimmune disease contraction, autoantibody detection reagent, and autoimmune disease test reagent

The present invention provides an autoantibody detection method that can detect an autoantibody causing an autoimmune disease with high accuracy. The autoantibody detection method of the present invention includes the steps of; causing a sample and an antigen reagent comprising a denatured protein presented by an mhc class ii molecule to come into contact with each other; and detecting a complex of an autoantibody in the sample and the denatured protein in the antigen reagent. ... Osaka University

06/15/17 / #20170170137

Bonding structure and method for producing bonding structure

A bonding structure (100) of the present invention includes a substrate (110), a metal film (120), a semiconductor element (130). The substrate (110), the metal film (120), and the semiconductor element (130) are laminated in order just mentioned. ... Osaka University

06/08/17 / #20170160190

Measuring device and measuring method

A measuring device (1) includes a first signal generation section (3) and a first removal section (5). The first signal generation section (3) generates a first source signal (x1(t)) including a fundamental and a plurality of harmonics based on a first physical quantity (p1) and a second physical quantity (p2). ... Osaka University

06/08/17 / #20170159020

Method for enhancing activity of laminin fragments as cell culture matrix

The present invention provides a novel technique in a cell culture method using a cell culture vessel coated with a laminin fragment, which novel technique achieves cell culture as in the case of using a recommended coating concentration even when the coating concentration is lower than the recommended coating concentration. The present invention relates to a method for enhancing an activity for mammalian cultured cells of a laminin fragment or a variant thereof each having integrin binding activity.. ... Osaka University

06/08/17 / #20170158848

Material for preventing adhesion of aquatic organisms

The present invention provides a material for preventing adhesion of an aquatic organism formed from a fluororesin and a fluorinated pitch.. . ... Osaka University

06/01/17 / #20170151219

Antiperspirant agent

The present invention provides an antiperspirant which can effectively and safely control perspiration. The antiperspirant in accordance with an aspect of the present invention contains a mtor inhibitor. ... Osaka University

05/11/17 / #20170130206

Mutant hemagglutinin complex protein, and method for culturing pluripotent stem cells using same

Provided are a novel hemagglutinin that can remove cells deviated from the undifferentiated state, the cells being cells that emerge in a colony during culture of stem cells having pluripotency, and a novel method for culturing stem cells having pluripotency, the method using hemagglutinin. Provided is a mutant hemagglutinin complex protein derived from clostridium botulinum type b, the complex protein containing at least subcomponents ha2 and ha3 of hemagglutinin derived from clostridium botulinum type b, and the complex protein containing amino acids constituting a glycosylation site, with at least one of the amino acids having been mutated. ... Osaka University

05/11/17 / #20170128487

Enhancer of anti-tumor effect of anti-cancer agent

An object of the present invention is to provide an agent that potentiates the antitumor effect of an anticancer agent by allowing efficient accumulation of the anticancer agent in tumor tissue. The administration of carbonate apatite with the anticancer agent allows efficient accumulation of the anticancer agent in the tumor tissue to dramatically potentiate the antitumor effect of the anticancer agent.. ... Osaka University

05/11/17 / #20170128053

Vagina evaluation device and uterus evaluation device

A non-invasive and accurate vagina evaluation device and uterine evaluation devices are provided that measure the receptivity (uterine implantation capacity) of the mother's body to a fertilized egg implanting itself into the uterus. A first vagina evaluation device includes: a main body stretchable and expandable after insertion into a vagina, followed by air injection thereinto; four electrodes brought into contact with the vagina wall as the main body expands and stretches; and fixation means configured to fix the interval of arrangement of the electrodes. ... Osaka University

04/27/17 / #20170115408

Neutron monitor device and neutron measurement method

Provided are a neutron monitor device and a neutron measurement method which make it easier to measure the intensity of the neutrons having the energy region of 10 kev to several hundreds kev. A neutron monitor device includes a first detector which includes a hemispherical first body formed of pe and having a radius of 31 mm, a first specimen containing gan disposed at the center of the first body, a cd layer provided on an outer surface of the first body, and a b layer provided inside the first body, and a second detector which includes a hemispherical second body formed of pe and having a radius of 27 mm, a second specimen containing gan disposed at the center of the second body, a b layer provided on the outer surface of the second body, and a cd layer provided inside the second body.. ... Osaka University

04/27/17 / #20170112861

Drug delivery enhancer comprising substance for activating lysophospholipid receptors

The present invention provides a drug delivery enhancer comprising, as an active ingredient, a substance that activates a lysophospholipid receptor, the enhancer being intended to be used for enhancing the delivery of a therapeutic drug for a disease involving abnormal blood vessel formation to an affected area; a pharmaceutical composition for treating a disease involving abnormal blood vessel formation, the composition comprising, as an active ingredient, a substance that activates a lysophospholipid receptor; and a method for screening for a therapeutic drug for a disease involving abnormal blood vessel formation, the method comprising selecting a substance that activates a lysophospholipid receptor specifically expressed in vascular endothelial cells of an affected area.. . ... Osaka University

04/20/17 / #20170108591

Gamma-ray measurement device and gamma-ray measurement method

Provided are a gamma-ray measurement device and a gamma-ray measurement method which perform a gamma-ray measurement of simple and inexpensive structure in a mixed field of neutrons and gamma-rays. A gamma-ray measurement device is used in a method for measuring the dose in the same place when using a lead filter and when not using the filter, and obtaining a gamma dose from a difference. ... Osaka University

04/06/17 / #20170098559

Planarizing processing method and planarizing processing device

A planarization processing device for polishing a substrate, such as a semiconductor wafer, includes a drive motor that rotates the substrate about a rotational axis. A support plate holds a pad for polishing the substrate such that the surface of the pad faces the surface of the substrate. ... Osaka University

04/06/17 / #20170097570

Resist patterning method, latent resist image forming device, and resist material

A resist patterning method according to the present invention includes a resist layer forming step, a patterned exposure step, a flood exposure step, and a developing step. In the resist layer forming step, a resist layer containing a base resin, a sensitizer precursor, an acid generator, and a base generator is formed on a substrate. ... Osaka University

03/30/17 / #20170093257

Rotary electric machine and rotary electric machine controller

A rotary electric machine includes a rotor that rotates around a rotation axis serving as a center and has a plurality of salient poles protruding in directions perpendicular to the rotation axis, and a stator that includes an annular structural body disposed radially outside the rotor and surrounding the rotor, and 6×n windings provided along a circumferential direction of the structural body, a field signal for generating field magnetic flux and a drive signal for driving the rotor as a three-phase rotary electric machine being superimposed on each other to be input to each of the windings. N is a natural number equal to or larger than one.. ... Osaka University

02/23/17 / #20170049398

Casing of implantable device and implantable device, method for manufacturing casing of implantable device, and method for supporting treatment using implantable device

To allow an implantable device including an electronic circuit to be implanted in the head in a more preferable manner in terms of appearance and safely. This implantable device is used for a brain-machine interface or the like. ... Osaka University

02/23/17 / #20170049387

Intracerebral current simulation method and device thereof, and transcranial magnetic stimulation system including intracerebral current simulation device

An intracerebral current simulation method including a first step of providing head image data; a second step of forming a three-dimensional brain model including micro-polyhedron units; a third step of providing first information which includes conditions under which a coil is placed on a patient's head, an electric current is applied to the coil, and the patient's reaction to the magnetic stimulation is observed, the conditions including a position and orientation of the coil, an electric current applied to the coil, and a structure relating to a generated magnetic field of the coil; and a fourth step of calculating an eddy current or electric field induced inside each of the micro-polyhedron units on the basis of the first information provided in the third step and second information which includes conductivity assigned to each micro-polyhedron unit. Also disclosed is a transcranial magnetic stimulation device and system.. ... Osaka University

02/16/17 / #20170044567

Polynucleotide encoding nf-yb derived from jatropha and use thereof

. . By analyzing a jatropha genome, nf-yb-encoding genes of seq id nos: 1 to 11, fragments of nf-yb-encoding genes of seq id nos: 12 and 13, and genes relating thereto were found. By transforming jatropha with these nf-yb-encoding genes and the like, it is possible to overexpress a nf-yb polypeptide and so on, and to significantly improve the productivity of protein synthesis involved by the nf-yb polypeptide, and to significantly improve the dry stress resistance, for example. ... Osaka University

02/09/17 / #20170035939

Adipocyte sheet, three-dimensional structure thereof, and method for producing the same

The present invention aims to provide an artificial tissue that can efficiently reproduce myocardial tissue function and that can be used in an actual implantation and produced by culturing. The present invention relates to a graft material for treating myocardial disease, the graft material including a cell sheet containing adipocytes.. ... Osaka University

02/02/17 / #20170031245

Substrate treatment system

A substrate treatment system for treating a substrate, includes: a treatment station in which a plurality of treatment apparatuses which treat the substrate are provided; an interface station which directly or indirectly delivers the substrate between an exposure apparatus which is provided outside the substrate treatment system and performs exposure of patterns on a resist film on the substrate, and the substrate treatment system; a light irradiation apparatus which performs post-exposure using uv light on the resist film on the substrate after the exposure of patterns is performed; and a post-exposure station which houses the light irradiation apparatus and is adjustable to a reduced pressure or inert gas atmosphere, wherein the post-exposure station is connected to the exposure apparatus directly or indirectly via a space which is adjustable to a reduced pressure or inert gas atmosphere.. . ... Osaka University

02/02/17 / #20170029474

Polypeptide and anti-tumor agent

Provided is a polypeptide comprising an r domain of crm197 and comprising one or more amino acid substitutions or deletions at positions selected from the group consisting of 391, 460, 466, 467, 468, 472, 507, and 520 of the r domain.. . ... Osaka University

01/12/17 / #20170007674

Method for preventing or reducing postoperative pulmonary complications

The present invention relates to methods for preventing or reducing the incidence of postoperative pulmonary complications in surgical patients after an esophagectomy. The inventors discovered that the occurrence of postoperative pulmonary complications after an esophagectomy may be reduced through the perioperative administration of ghrelin to surgical patients.. ... Osaka University

01/05/17 / #20170000472

Retractor

A retractor has a rigid piercing tube and an expansion body. The expansion body has an introduction tube which is received within the piercing tube, a movable wire which is received within the introduction tube, and stationary wires which are arranged around the movable wire. ... Osaka University








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