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Oxford Nanopore Technologies Ltd patents


Recent patent applications related to Oxford Nanopore Technologies Ltd. Oxford Nanopore Technologies Ltd is listed as an Agent/Assignee. Note: Oxford Nanopore Technologies Ltd may have other listings under different names/spellings. We're not affiliated with Oxford Nanopore Technologies Ltd, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "O" | Oxford Nanopore Technologies Ltd-related inventors


Modified enzymes

The invention relates to modified dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.. . ... Oxford Nanopore Technologies Ltd

Apparatus and methods for measuring an electrical current

Arrangements are disclosed for measuring small electrical currents with high sensitivity, for example in the context of sensing molecular entities, for example via interactions between the molecular entities and a membrane protein inserted in an amphiphilic membrane. In one arrangement there is provided a current sensing circuit (52) configured to integrate the current output by a sensor element (56) during each of a plurality of sensing frames (62). ... Oxford Nanopore Technologies Ltd

Method

The invention relates to a novel method of producing hetero-oligomeric pores. The invention also relates to hetero-oligomeric pores produced using the method and polynucleotide characterisation using the hetero-oligomeric pores.. ... Oxford Nanopore Technologies Ltd

Enzyme method

The invention relates to a new method of characterizing a target polynucleotide. The method uses a pore and a hel308 helicase or amolecular motor which is capable of binding to the target polynucleotide at an internal nucleotide. ... Oxford Nanopore Technologies Ltd

Hetero-pores

The invention relates to hetero-oligomeric pores derived from msp. The invention also relates to polynucleotide characterisation using the hetero-oligomeric pores.. ... Oxford Nanopore Technologies Ltd

Formation of layers of amphiphilic molecules

To form a layer separating two volumes of aqueous solution, there is used an apparatus comprising elements defining a chamber, the elements including a body of non-conductive material having formed therein at least one recess opening into the chamber, the recess containing an electrode. A pre-treatment coating of a hydrophobic fluid is applied to the body across the recess. ... Oxford Nanopore Technologies Ltd

Biochemical analysis instrument

An analysis instrument comprises plural modules connected together over a data network, each module comprising an analysis apparatus operable to perform biochemical analysis of a sample. Each module comprises a control unit that controls the operation of the analysis apparatus. ... Oxford Nanopore Technologies Ltd

Enzyme-pore constructs

The invention relates to constructs comprising a transmembrane protein pore subunit and a nucleic acid handling enzyme. The pore subunit is covalently attached to the enzyme such that both the subunit and enzyme retain their activity. ... Oxford Nanopore Technologies Ltd

Biochemical analysis apparatus and rotary valve

An analysis apparatus for performing biochemical analysis of a sample using nanopores comprises: a sensor device that that supports plural nanopores, reservoirs holding material for performing the analysis; a fluidics system; and plural containers for receiving respective samples, all arranged in a cartridge that is removably attachable to an electronics unit arranged to generate drive signals to perform signal processing circuit to generate output data representing the results of the analysis. The fluidics system supplies samples selectively from the containers to the sensor device using a rotary valve. ... Oxford Nanopore Technologies Ltd

Electrical device with detachable components

A detachable electrical device can be formed from a kit comprising a pair of component parts adapted for connection to each other, wherein the connected components of the device may be subsequently disconnected, comprising: an array of electrical connectors, each electrical connector comprising an electrically conductive liquid; and an array of electrodes; wherein the arrays can be brought into contact with each other so as to provide a plurality of electrical connections between the electrically conductive liquid of the array of electrical connectors and the electrodes of the array of electrodes, and wherein the electrical connections may be subsequently broken by detaching the electrically conductive liquid from the electrodes of the array.. . ... Oxford Nanopore Technologies Ltd

Pump

A pump for use in low-profile applications comprises a barrel for holding fluid; and a piston that converts a rotational driving force into a longitudinal driving motion within the barrel. The pump provides space saving advantages by reducing the need for external equipment and mechanisms around the pump for providing actuation or moving the actuating mechanism.. ... Oxford Nanopore Technologies Ltd

Adaptors for nucleic acid constructs in transmembrane sequencing

The invention relates to adaptors for sequencing nucleic acids. The adaptors may be used to generate single stranded constructs of nucleic acid for sequencing purposes. ... Oxford Nanopore Technologies Ltd

Mutant pores

The invention relates to mutant forms of msp. The invention also relates to polynucleotide characterisation using msp.. ... Oxford Nanopore Technologies Ltd

Method for nanopore rna characterisation

The invention relates to a new method of characterising fig. 3 a target rna polynucleotide by taking one or more measurements as the target rna polynucleotide moves with respect to a transmembrane pore. ... Oxford Nanopore Technologies Ltd

09/07/17 / #20170253910

Methods for delivering an analyte to transmembrane pores

The invention relates to a new method of delivering an analyte to a transmembrane pore in a membrane. The method involves the use of microparticles.. ... Oxford Nanopore Technologies Ltd

08/24/17 / #20170240955

Method

The invention relates to a method for modifying a template double stranded polynucleotide, especially for characterisation using nanopore sequencing. The method produces from the template a plurality of modified double stranded polynucleotides. ... Oxford Nanopore Technologies Ltd

08/17/17 / #20170233804

Analysis of a polymer

Analysis of a polymer a biochemical analysis system analyses polymers by taking measurements of a polymer from a sensor element comprising a nanopore during translocation of the polymer through the nanopore. When a polymer has partially translocated, the series of measurements is analysed using reference data derived from a reference sequence to provide a measure of similarity. ... Oxford Nanopore Technologies Ltd

08/03/17 / #20170219557

Analysis of a polymer comprising polymer units

A sequence of polymer units in a polymer (3), eg. Dna, is estimated from at least one series of measurements related to the polymer, eg. ... Oxford Nanopore Technologies Ltd

07/20/17 / #20170204457

Method for characterising a double stranded nucleic acid using a nano-pore and anchor molecules at both ends of said nucleic acid

The invention relates to a method for method of characterising, such as sequencing, a target double stranded polynucleotide. The polynucleotide is coupled to a membrane using at least two adaptors with different strengths of coupling to the membrane.. ... Oxford Nanopore Technologies Ltd

04/20/17 / #20170107569

Method for attaching one or more polynucleotide binding proteins to a target polynucleotide

The invention relates to new methods of attaching one or more polynucleotide binding proteins to a target polynucleotide. The invention also relates to new methods of characterising target polynucleotides.. ... Oxford Nanopore Technologies Ltd

04/06/17 / #20170096703

Analysis of a polymer from multi-dimensional measurements

A target sequence of polymer units is estimated from plural series of measurements taken from sequences of polymer units that comprise the target sequence or a complementary sequence. Each measurement is dependent on a k-mer (k polymer units). ... Oxford Nanopore Technologies Ltd

03/30/17 / #20170091427

Model adjustment during analysis of a polymer from nanopore measurements

An estimate of a target sequence of polymer units is generated from a series of measurements taken by a measurement system comprising nanopores during translocation of the polymer through a nanopore. A global model of the measurement system is stored, comprising transition weightings for possible transitions between k-mers on which successive measurements are dependent and emission weightings for possible values of measurements being observed when the measurement is dependent on possible identities of k-mer. ... Oxford Nanopore Technologies Ltd

03/09/17 / #20170067101

Sample preparation method

The invention relates to an improved method for characterising a template polynucleotide. The method involves using a polymerase to prepare a modified polynucleotide which makes it easier to characterise than the template polynucleotide.. ... Oxford Nanopore Technologies Ltd

03/02/17 / #20170058338

Method of improving the movement of a target polynucleotide with respect to a transmembrane pore

The invention relates to improving the movement of a target polynucleotide with respect to a transmembrane pore when the movement is controlled by a polynucleotide binding protein. The invention also relates to improved transmembrane pores and polynucleotide binding proteins.. ... Oxford Nanopore Technologies Ltd

03/02/17 / #20170058337

Mutant pores

The invention relates to mutant forms of msp. The invention also relates to polynucleotide characterisation using msp.. ... Oxford Nanopore Technologies Ltd

01/26/17 / #20170022557

Method of target molecule characterisation using a molecular pore

The invention relates to a new method of determining the presence, absence or one or more characteristics of multiple analytes. The invention concerns coupling a first analyte to a membrane containing a detector and investigating the first analyte using the detector. ... Oxford Nanopore Technologies Ltd

01/05/17 / #20170002406

Method for controlling the movement of a polynucleotide through a transmembrane pore

The invention relates to new methods of controlling the movement of polynucleotides through transmembrane pores. The invention also relates to new methods of characterising target polynucleotides using helicases.. ... Oxford Nanopore Technologies Ltd








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