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Pennsy Corporation patents


Recent patent applications related to Pennsy Corporation. Pennsy Corporation is listed as an Agent/Assignee. Note: Pennsy Corporation may have other listings under different names/spellings. We're not affiliated with Pennsy Corporation, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "P" | Pennsy Corporation-related inventors


 new patent  A method of magnetically aligning and crystallizing membrane proteins

The disclosure describes a method of forming highly ordered membrane protein crystals. The forming process is done in the presence of a magnetic field to exploit the diamagnetic anisotropy of the membrane protein. ... Pennsy Corporation

Compositions and methods for the modulation of root hair production and stress responses in plants

Compositions and methods for modulating root hair production and stress responses in plants are provided.. . ... Pennsy Corporation

Compositions and methods for altering tissue specificity and improving aav9-mediated gene transfer

A method of altering the targeting and/or cellular uptake efficiency of an adeno-associated virus (aav) viral vector having a capsid containing an aav9 cell surface binding domain is described. The method involves modifying a clade f cell surface receptor which comprises a glycan having a terminal sialic acid residue and a penultimate β-galactose residue. ... Pennsy Corporation

Resiquimod topical and injectable compositions for the treatment of neoplastic skin conditions

Compositions and methods for treatment of viral skin disease, precancerous and cancerous skin disease, and other neoplasms are disclosed.. . ... Pennsy Corporation

Engineered human anti-aav antibodies and uses thereof

A method for generating engineered human anti-aav antibodies is described. Also described are compositions, panels and arrays containing these antibodies and uses thereof.. ... Pennsy Corporation

Spectral emission modification using localized surface plasmon of metallic nanoparticles

A method for engineering a line shape of emission spectrum of an organic emissive material in an electroluminescent device is disclosed in which a layer of plasmonic metallic nanostructures having a localized surface plasmonic resonance (lspr) is provided in proximity to the emissive layer and the layer of plasmonic metallic nanostructures is greater than 2 nm but less than 100 nm from the emissive layer and the lspr of the plasmonic metallic nanostructures matches the emission wavelength of the organic emissive material. An electroluminescent device incorporating the plasmonic metallic nanostructures is also disclosed.. ... Pennsy Corporation

Thin film metal silicides and methods for formation

The disclosed subject matter provides thin films including a metal silicide and methods for forming such films. The disclosed subject matter can provide techniques for tailoring the electronic structure of metal thin films to produce desirable properties. ... Pennsy Corporation

In vitro artificial lymph node method for sensitization and expansion of t cells for therapy and epitope mapping

A method of creating a microenvironment for culture expansion of t cells. The expanded t cells can be used for a variety of therapeutic and research purposes.. ... Pennsy Corporation

Methods and compositions for stimulating immune response using potent immunostimulatory rna motifs

The presently disclosed subject matter relates to methods and compositions relating to immunostimulatory rna motifs that act as adjuvants and/or immunostimulatory agents to enhance host immune responses.. . ... Pennsy Corporation

Mechano-sensitive microcapsules for drug delivery

Embodiments of the present invention relate to mechanically-activated microcapsules (mamcs) for controlled drug-delivery, wherein the mamcs release one or more active ingredients in response to mechanical stimuli in a subject's body. The mamcs provide a platform for stimulating biological regeneration, biological repair, modifying disease, and/or controlling disease in mechanically-loaded musculoskeletal tissues.. ... Pennsy Corporation

Compositions and methods for degradation of misfolded proteins

The present invention relates to compositions and methods for promoting the degradation of misfolded proteins and protein aggregates. The compositions and methods may be used to treat a disorder associated with misfolded proteins or protein aggregates. ... Pennsy Corporation

211-astatine containing radiotherapeutics for the treatment of cancer

Described herein is an alpha-emitting radionuclide, 211at, which has been incorporated into a selective sigma-2 ligand moiety to provide cytotoxic capabilities to a chemical compound. As described herein, a compound of formula (i), wherein r1-r4, m, and n are defined herein, was prepared and utilized in in vitro and in vivo tumor targeting of alpha-emitting sigma-2 ligand in a breast cancer model. ... Pennsy Corporation

Use of the irritating principal oleocanthal in olive oil, as well as structurally and functionally similar compounds

The invention provides methods of synthesizing the purified enantiomers of oleocanthal. The invention further provides methods of using oleocanthals in various formulations including, food additives; pharmaceuticals; cosmetics; animal repellants; and discovery tools for mammalian irritation receptor genes, gene products, alleles, splice variants, alternate transcripts and the like.. ... Pennsy Corporation

Methods for modulating an inflammatory response

The inventive subject matter relates to novel methods for modulating an immune response in an animal, which comprises administering to said animal an effective amount of an agent that increases il-27r/wsx-1 activity. Further, the inventive subject matter relates to pharmaceutical compositions comprising an effective amount of an agent that increases il-27r/wsx-1 activity.. ... Pennsy Corporation

06/07/18 / #20180160530

Scalable, printable, patterned sheet of high mobility graphene on flexible substrates

The present invention provides methods for fabricating graphene workpieces. The present invention also provides for products produced by the methods of the present invention and for apparatuses used to perform the methods of the present invention.. ... Pennsy Corporation

06/07/18 / #20180155412

Aav-mediated expression of anti-influenza antibodies and methods of use thereof

Aav vectors expressing anti-influenza antibodies are provided. Also described are pharmaceutical compositions useful in delivery same for prophylactic or anti-viral purposes. ... Pennsy Corporation

06/07/18 / #20180153962

Synergistic combination of neuronal viability factors and uses thereof

The present invention relates to the synergistic combination of the short and long rod-derived cone viability factors and to methods for treating retinal degenerative diseases.. . ... Pennsy Corporation

05/24/18 / #20180140602

Combination of chimeric antigen receptor therapy and amino pyrimidine derivatives

The invention provides compositions and methods for treating diseases associated with expression of cd19, e.g., by administering a recombinant t cell comprising the cd19 car as described herein, in combination with a btk inhibitor, e.g., an amino pyrimidine derivative described herein. The invention also provides kits and compositions described herein.. ... Pennsy Corporation

05/17/18 / #20180135030

Compositions useful in treatment of ornithine transcarbamylase (otc) deficiency

Non-viral delivery systems comprising engineered hotc dna and rna sequences are provided which when delivered to a subject in need thereof are useful for treating hyperammonemia, ornithine transcarbamylase deficiency and symptoms associated therewith. Also provided are methods of using hotc for treatment of liver fibrosis and/or cirrhosis in otcd patients by administering hotc.. ... Pennsy Corporation

05/17/18 / #20180133307

Influenza nucleic acid molecules and vaccines therefrom

Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of ha hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more influenza a serotpyes using the vaccines that are provided.. ... Pennsy Corporation

05/10/18 / #20180127676

Nano-additives enabled advanced lubricants

The presently disclosed technology relates to a nano-additives to improve the performance of lubricants, oils, and greases. More specifically, the presently disclosed technology relates to applying capped metal oxide nanoparticles, such as capped zirconia nanoparticles, in the lubricants to produce a tribofilms on the lubricating surfaces to provide wear protection to the said surfaces. ... Pennsy Corporation

05/10/18 / #20180127577

Bijels and methods of making the same

A method of making a bijel includes dispersing surface-active nanoparticles in a ternary liquid mixture. The ternary liquid mixture includes a hydrophilic liquid, a hydrophobic liquid, and a solvent. ... Pennsy Corporation

05/10/18 / #20180125984

Drug-containing implants and methods of use thereof

The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (pla) and optionally polyglycolic acid (pga). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia and other diseases and disorders, utilizing implants of the present invention.. ... Pennsy Corporation

05/03/18 / #20180118834

Phosphoglycerate kinase 1 (pgk) promoters and methods of use for expressing chimeric antigen receptor

The invention provides compositions and methods for treating diseases associated with expression of a tumor antigen as described herein. The invention also relates to nucleic acids comprising a truncated pgk promoter operably linked to a chimeric antigen receptor (car) specific to a tumor antigen as described herein, vectors encoding the same, and recombinant t cells comprising the cars of the present invention. ... Pennsy Corporation

05/03/18 / #20180118785

Compstatin analogs with improved activity

Compounds comprising peptides and peptidomimetics capable of binding the c3 protein and inhibiting complement activation are disclosed. These compounds display improved complement activation-inhibitory activity as compared with currently available compounds. ... Pennsy Corporation

04/19/18 / #20180107879

System and method for adaptive, rapidly deployable, human-intelligent sensor feeds

The disclosure describes a sensor system that provides end users with intelligent sensing capabilities, and embodies both crowd sourcing and machine learning together. Further, a sporadic crowd assessment is used to ensure continued sensor accuracy when the system is relying on machine learning analysis. ... Pennsy Corporation

04/19/18 / #20180104365

Radiotracer derivatives of trimethoprim for diagnositc imaging

The present invention provides radiolabeled trimethoprim which are useful in imaging tests such as pet scans. The compounds show robust bacterial uptake in vitro and identify infections from inflammation or tumor when administered to a subject. ... Pennsy Corporation

04/05/18 / #20180092968

Compositions to disrupt protein kinase a anchoring and uses thereof

The invention provides compositions and methods for treating diseases associated with expression of a cancer associated antigen as described herein. The invention also relates to chimeric antigen receptor (car) specific to a cancer associated antigen and modified t-cell receptor (tcr) t cells as described herein, vectors encoding the same, and recombinant t cells comprising the cars or tcrs of the present invention. ... Pennsy Corporation

03/29/18 / #20180088597

Multi-sensor fusion for robust autonomous flight in indoor and outdoor environments with a rotorcraft micro-aerial vehicle (mav)

The subject matter described herein includes a modular and extensible approach to integrate noisy measurements from multiple heterogeneous sensors that yield either absolute or relative observations at different and varying time intervals, and to provide smooth and globally consistent estimates of position in real time for autonomous flight. We describe the development of the algorithms and software architecture for a new 1.9 kg mav platform equipped with an imu, laser scanner, stereo cameras, pressure altimeter, magnetometer, and a gps receiver, in which the state estimation and control are performed onboard on an intel nuc 3rd generation i3 processor. ... Pennsy Corporation

03/29/18 / #20180085168

System and method for virtual radiation therapy quality assurance

A method comprises receiving one or more plan parameters of a first radiation treatment plan for a first patient and one or more passing rate data for the first treatment plan; generating a predictive model for passing rate data from the plan parameters of the first radiation treatment plan and the passing rate data for the first treatment plan; receiving one or more plan parameters of a second radiation treatment plan for a second patient; and applying the predictive model to the plan parameters of the second radiation treatment to generate one or more predicted passing rate data for the plan parameters for the second patient.. . ... Pennsy Corporation

03/29/18 / #20180085050

Systems and methods for individualized sleep optimization

Systems and methods for sleep management are disclosed. The systems and methods, utilize one or more peripheral devices, a network, one or more networked computers, and one or more remote servers. ... Pennsy Corporation

03/22/18 / #20180079821

Fusion proteins for modulating regulatory and effector t cells

The present invention provides fusion proteins that act on the glucocorticoid-induced tnfr family-related gene (gitr) and ox40 signaling pathway. The proteins of the invention are useful in modulating both regulatory t (treg) cells and effector t (teff) cells.. ... Pennsy Corporation

03/22/18 / #20180079785

Aza-amino acid collagen compounds

The invention relates to aza-amino acid backbone-modified biomimetic collagens and general methods for designing and making biomimetic materials and molecular mimics.. . ... Pennsy Corporation

03/22/18 / #20180078682

Antibacterial coatings that inhibit biofilm formation on implants

Orthopedic and dental implants coated with an antibacterial coating and methods of making and using, are described herein. The implant can be coated with a hydrophobic, polycationic antibacterial polymer. ... Pennsy Corporation

03/22/18 / #20180078638

Isg15 and its use as an adjuvant

Disclosed herein is a vaccine comprising an antigen and isg15. Also disclosed herein is a method for increasing an immune response in a subject in need thereof. ... Pennsy Corporation

03/22/18 / #20180078631

Synthetic immunogens for prophylaxis or treatment of tuberculosis

Compositions comprising a nucleic acid molecule that encodes tb esat-6 proteins are disclosed. Methods of inducing an immune response against tb an individual are disclosed. ... Pennsy Corporation

03/15/18 / #20180071272

Novel chronotherapy based on circadian rhythms

The invention includes a formulation of a therapeutic compound, wherein release of the therapeutic compound from the formulation coincides with peak or trough expression of at least one target gene of the therapeutic compound. The invention also includes a method of developing such formulations and a method of treating a disorder in a subject using such formulations.. ... Pennsy Corporation

03/15/18 / #20180071233

Compositions and methods for treating asthma and other lung diseases

The present invention provides methods for dilating the bronchi or bronchioles and relaxing a pulmonary smooth muscle in a subject by treating the subject with a pharmaceutical composition, which includes a histone deacetylase (hdac) inhibitor. The ability to dilate the bronchi or bronchioles and relax a pulmonary smooth muscle according to the methods of the invention allows treating, alleviating, or inhibiting bronchoconstrictive diseases or disorders and symptoms associated or derived from bronchoconstrictive diseases.. ... Pennsy Corporation

03/08/18 / #20180064732

Compositions and methods for suppressing or reducing systemic immune response in a subject

The present invention includes a method of suppressing systemic immune response in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin d analog to a subject in need thereof. The present invention further includes a method of treating an autoimmune disease in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin d analog to a subject in need thereof.. ... Pennsy Corporation

03/01/18 / #20180062140

Polymerized ionic liquid block copolymers as battery membranes

. . The present invention is directed to lithium ion transport media for use in separators in lithium ion batteries, and the membranes, separators, and devices derived therefrom.. . ... Pennsy Corporation

03/01/18 / #20180057841

Method of increasing the function of an aav vector

A method of correcting singletons in a selected aav sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected aav is provided. This method involves altering one or more singletons in the parental aav capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional aav capsid sequences.. ... Pennsy Corporation

03/01/18 / #20180057609

Enhancing activity of car t cells by co-introducing a bispecific antibody

The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a t cell, genetically modified to express a chimeric antigen receptor (car), a bispecific antibody, or a combination thereof to a subject. ... Pennsy Corporation

03/01/18 / #20180057557

Methods and compositions of a follicle stimulating hormone receptor immunoreceptor or chimeric antigen receptor

The present invention relates to compositions and methods for diagnosing and treating diseases, disorders or conditions associated with dysregulated expression of fshr. The invention provides novel peptides that specifically bind to follicle-stimulation hormone receptor (fshr).. ... Pennsy Corporation

02/22/18 / #20180051243

System, method, and device for high-throughput, automated culturing of genetically modified organisms

A fluid transfer system includes a transfer carousel capable of rotational and/or translational movement; at least one holding vessel (e.g. Syringe) having a plunger, wherein the syringe is connected to the transfer carousel such that the movement of the transfer carousel results in movement of the syringe and wherein the syringe is capable of translational movement relative to the transfer carousel; a drive motor connected to the syringe that is capable of controlling the position of the plunger; and a peripheral module comprising at least one vessel that is capable of containing a fluid, wherein the vessel has an opening that can be mated with the syringe to allow fluid transfer between the vessel and the syringe. ... Pennsy Corporation

02/15/18 / #20180044623

Artificial placenta and methods of preparation

The presently disclosed subject matter provides a microfluidic device that can simulate capillary blood flow on a fetal side of the device and pooled blood on a maternal side of the device (i.e., intervillous space). The microfluidic device can reconstitute the maternal-fetal interface, can expand the capabilities of cell culture models, and can provide an alternative to current maternal-fetal transfer models.. ... Pennsy Corporation

02/15/18 / #20180044424

Car-expressing cells against multiple tumor antigens and uses thereof

The invention provides compositions and methods for treating cancer by using immune effector cells (e.g., t cells, nk cells) engineered to conditionally express an agent which enhances the immune effector response of an immune effector cell that expresses a chimeric antigen receptor (car). The conditional agents described herein include agents that target a cancer associated antigen, e.g., a car, agents that inhibit one or more checkpoint inhibitors of the immune response, and a cytokine.. ... Pennsy Corporation

02/15/18 / #20180044423

Treatment of cancer using a cd33 chimeric antigen receptor

The invention provides compositions and methods for treating diseases associated with expression of cd33. The invention also relates to chimeric antigen receptor (car) specific to cd33, vectors encoding the same, and recombinant t cells comprising the cd33 car. ... Pennsy Corporation

02/08/18 / #20180039402

User interface input method and system for handheld and mobile devices

Methods, systems, and computer readable media for receiving user input. According to one example method for receiving user input, the method includes identifying gestures from directional movements of a user's fingers on a touch sensor, mapping the gestures to alphanumeric characters, and outputting alphanumeric characters, including defining a set of the gestures as different sequences of at least two of: a contact event, a no contact event, a hold event, a finger movement in a first direction, a finger movement in a second direction.. ... Pennsy Corporation

02/08/18 / #20180037625

Use of the cd2 signaling domain in second-generation chimeric antigen receptors

The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified t cell expressing a car having an antigen binding domain, a transmembrane domain, a cd2 signaling domain, and a cd3 zeta signaling domain. ... Pennsy Corporation

02/01/18 / #20180030502

Regulation of autophagy and cell survival

Methods of treating an individual who has been identified as having glycolysis dependent cancer are disclosed. The methods comprise the step of: administering to suc an individual a combination of an anti-cancer composition that renders the cancer incapable of glycolysis and an autophagy inhibitor. ... Pennsy Corporation

02/01/18 / #20180030479

Method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby

Adeno-associated virus rh.10 sequences, vectors containing same, and methods of use are provided.. . ... Pennsy Corporation

02/01/18 / #20180030110

Fully-human t-cell receptor specific for the 369-377 epitope derived from the her2/neu (erbb2) receptor protein.

The present invention relates to compositions and methods for treating her2/neu (erbb2) expressing cancer cells. In some embodiments, the invention includes an isolated t cell receptor (tcr) having high affinity for and that specifically binds erbb2369-377 epitope on a target cell. ... Pennsy Corporation

02/01/18 / #20180028672

Protease triggered release of molecules from hydrogels

The invention relates to compositions comprising (i) biocompatible hydrogel and (ii) one or more therapeutic agents contained within said hydrogel; wherein the hydrogel is cross-linked utilizing a cross-linker comprising a peptide sequence that is capable of being degraded by an enzyme; the therapeutic agent being effective as a treatment of a condition related to the presence of the enzyme.. . ... Pennsy Corporation

02/01/18 / #20180028640

Proteins comprising mrsa pbp2a and fragments thereof, nucleic acids encoding the same, and compositions and their use to prevent and treat mrsa infections

Nucleic acid molecules which encode an mrsa pbp2a protein or a fragment thereof which comprises at least 245 amino acid are disclosed. Compositions comprising the nucleic acid molecules are disclosed. ... Pennsy Corporation

02/01/18 / #20180028625

Administration of plant expressed oral tolerance agents

Protein replacement therapy for patients with hemophilia or other inherited protein deficiencies is other complicated by pathogenic antibody responses, including antibodies that neutralize the therapeutic protein or that predispose to potentially life-threatening anaphylactic reactions by formation of ige. Using murine hemophilia b as a model, we have developed a prophylactic protocol against such responses that is non-invasive and does not include immune suppression or genetic manipulation of the patient's cells. ... Pennsy Corporation

02/01/18 / #20180028417

Iron oxide nanoparticles and methods of use thereof

The presently disclosed subject matter relates to iron oxide nanoparticle compositions and formulations thereof for: (1) the treatment and elimination of biofilms; (2) the prevention of biofilm formation; (3) biofilm extracellular matrix degradation; (4) the inhibition of bacterial viability and growth within the biofilm; and (5) the prevention of tooth or apatitic demineralization. In particular, the presently disclosed subject matter provides a composition for the prevention and treatment of an oral disease (e.g., dental caries) that includes one or more iron oxide nanoparticles and hydrogen peroxide.. ... Pennsy Corporation

01/25/18 / #20180024140

Atomic description of immune complex that causes heparin-induced thrombocytopenia

The present invention provides a humanized antibody or antibody fragment comprising (a) a humanized light chain comprising 1) complementarity determining region (cdr)-l1, the sequence of which is identical to the sequence of seq id no: 3; 2) cdr-l2, the sequence of which is identical to the sequence of seq id no: 4; and 3) cdr-l3, the sequence of which is identical to the sequence of seq id no: 5, and (b) a humanized heavy chain comprising 1) cdr-h1, the sequence of which is identical to the sequence of seq id no: 6; 2) cdr-h2, the sequence of which is identical to the sequence of seq id no: 7; and 3) cdr-h3, the sequence of which is identical to the sequence of seq id no: 8, as well as methods for treating, diagnosing, and monitoring the progression of hit. The present invention also provides methods for assessing the antigenicity and ability to cause hit of anionic anticoagulants. ... Pennsy Corporation

01/25/18 / #20180022795

Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy

The present invention provides compositions and methods for regulating the specificity and activity of t cells. In one embodiment, the invention provides a type of chimeric antigen receptor (car) wherein the car is termed a “kir-car” which is a car design comprising a component of a receptor naturally found on natural killer (nk) cells. ... Pennsy Corporation

01/25/18 / #20180021579

Method and apparatus for improving cognitive performance

A method for delivering electrical stimulation to alter a cognitive state of a user, the method comprising: monitoring a brain signal from the user via one or more intracranial electrodes implanted in the brain of the user while the user is presented with a stimulus; comparing the brain signal to a testing phase biomarker, wherein the testing phase biomarker is derived from a cognitive test performed on a contributor during a testing phase; delivering electrical stimulation to a brain of the user based on the comparing step to steer the brain of the user towards a high performance cognitive state.. . ... Pennsy Corporation

01/18/18 / #20180016638

Novel methods for early identification of bone healing ability in injured patients

The present invention relates to the discovery that the expression levels of some rna molecules, comprising messenger rna (mrna), non-coding rna (ncrna) and/or microrna (mirna), and protein can be used as a diagnostic signature to predict or monitor the bone healing ability in an acutely injured subject or in a chronic nonunion subject. In certain embodiments, the invention relates to methods and compositions useful for differentiating between a nonunion, slow healing, and/or normal healing of a fractured bone and treatment recommendations. ... Pennsy Corporation

01/18/18 / #20180016598

Simian adenoviruses sadv-43, -45, -46, -47, -48, -49, and -50, and uses thereof

A recombinant vector comprises simian adenovirus 43, 45, 46, 47, 48, 49 or 50 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus 43, 45, 46, 47, 48, 49 or 50 gene(s) is also disclosed. ... Pennsy Corporation

01/18/18 / #20180015149

Collagen iii composition and uses

The invention includes methods of suppressing cancer metastasis and local recurrence in a subject. In one aspect, the method comprises removing the tumor by surgery; and implanting a composition of the invention to the site of the primary tumor. ... Pennsy Corporation

01/04/18 / #20180002716

Compositions and methods thereof for down-regulation of genes following oral delivery of an rnai molecule bioencapsulated within plant cells

Compositions and methods for down-regulating genes through oral administration of rnai molecule encapsulated in plant cells are provided.. . ... Pennsy Corporation

01/04/18 / #20180002698

C-rel-specific sirna and its use for preventing and treating autoimmune psoriasis

The present invention provides a c-rel-specific sirna and its use for preventing and treating autoimmune psoriasis. In particular, the c-rel-specific sirnas have sequences as shown in seq id nos. ... Pennsy Corporation

01/04/18 / #20180000928

Immunogenicity of an optimized synthetic consensus dna vaccine for porcine epidemic diarrhea virus

Provided herein is a vaccine comprising a porcine epidemic diarrhea virus (pedv) antigen. The antigen can be a consensus antigen. ... Pennsy Corporation

12/28/17 / #20170372137

Systems, devices, and methods for robotic remote sensing for precision agriculture

The present subject matter relates to systems, devices, and methods for data-driven precision agriculture through close-range remote sensing with a versatile imaging system. This imaging system can be deployed onboard low-flying unmanned aerial vehicles (uavs) and/or carried by human scouts. ... Pennsy Corporation

12/28/17 / #20170369777

Morphologically and size uniform monodisperse particles and their shape-directed self-assembly

Monodisperse particles having: a single pure crystalline phase of a rare earth-containing lattice, a uniform three-dimensional size, and a uniform polyhedral morphology are disclosed. Due to their uniform size and shape, the monodisperse particles self assemble into superlattices. ... Pennsy Corporation

12/28/17 / #20170368180

Methods of promoting nervous system regeneration

The invention includes a composition comprising an astrocyte comprising aligned and elongated astrocyte processes resulting from ex vivo machine-driven, physical stretching of the astrocyte maintained in culture, as well as a method of making it. The invention also includes a composition comprising an astrocyte comprising aligned bi-polar processes resulting from growth within hydrogel micro-columns in culture, as well as a method of making it. ... Pennsy Corporation

12/21/17 / #20170365057

Semi-automated heart valve morphometry and computational stress analysis from 3d images

A method is provided for measuring or estimating stress distributions on heart valve leaflets by obtaining three-dimensional images of the heart valve leaflets, segmenting the heart valve leaflets in the three-dimensional images by capturing locally varying thicknesses of the heart valve leaflets in three-dimensional image data to generate an image-derived patient-specific model of the heart valve leaflets, and applying the image-derived patient-specific model of the heart valve leaflets to a finite element analysis (fea) algorithm to estimate stresses on the heart valve leaflets. The images of the heart valve leaflets may be obtained using real-time 3d transesophageal echocardiography (rt-3dtee). ... Pennsy Corporation

12/21/17 / #20170362669

Compositions, kits, and methods to detect hiv virus

Provided herein include compositions comprising a primer having the nucleic acid sequence of acein-f3_c, a primer having the nucleic acid sequence of acein-b3_a, a primer having the nucleic acid sequence of acein-b3_b, a primer having the nucleic acid sequence of acein-fip_e, a primer having the nucleic acid sequence of acein-fip_f, a primer having the nucleic acid sequence of acein-bip (or acein-bip-song), a primer having the nucleic acid sequence of acein-lf; and a primer having the nucleic acid sequence of acein-lb. Also provided are methods of detecting human immunodeficiency virus (hiv) nucleic acids in a sample comprising performing reverse transcription-based loop mediated isothermal amplification (rt-lamp) on a sample using the previously disclosed compositions.. ... Pennsy Corporation

12/21/17 / #20170362295

Use of icos-based cars to enhance antitumor activity and car persistence

The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a genetically modified th17 cell to express a car having an antigen binding domain, a transmembrane domain, and an icos intracellular signaling domain.. ... Pennsy Corporation

12/21/17 / #20170360913

Compositions and methods for t cell delivery of therapeutic molecules

The present invention includes compositions and methods for modifying a t cell with a nucleic acid encoding a switch molecule comprising an extracellular domain comprising a membrane receptor or fragment thereof and an intracellular domain comprising a signaling receptor or fragment thereof. In one aspect, a method comprises introducing a nucleic acid encoding a switch molecule and a nucleic acid encoding a soluble fusion protein and/or a nucleic acid encoding a bispecific antibody into a population of cells comprising t cells, wherein the t cells transiently expresses the switch molecule and soluble fusion protein or bispecific antibody. ... Pennsy Corporation

12/14/17 / #20170355778

Compositions and methods of treating tumors

Methods of treating an individual who has an erbb protein mediated tumor is disclosed. Methods of preventing erbb protein mediated tumors in an individual are disclosed. ... Pennsy Corporation

12/14/17 / #20170354369

Methods and systems for testing opticokinetic nystagmus

A mobile system for measuring opticokinetic nystagmus in a subject includes a display screen to provide an opticokinetic stimulus and an imaging system to record eye movement data of the subject. The mobile system is configured to compare the stimulus and the recorded eye movement data to provide objective vision acuity testing.. ... Pennsy Corporation

12/14/17 / #20170354324

Vision test for determining retinal disease progression

The present invention provides a reading test to measure vision loss. In one embodiment, the vision loss is due to disease progression. ... Pennsy Corporation

11/30/17 / #20170343565

Biomarkers for seizures

The application relates to markers for seizures and epilepsy. Polypeptide expression panels or arrays are provided, comprising one or more probes capable of binding specific polypeptides in blood plasma or blood serum of a mammalian subject. ... Pennsy Corporation

11/30/17 / #20170343533

Fluid separator for point of care molecular diagnostics

The present disclosure provides devices and methods using plasma coil r separating a fluid—e.g., plasma or serum—from whole blood. In some embodiments, the devices and methods use hydrophobic or superhydrophobic surfaces to encourage whole blood to contact a selective membrane that extracts the desired fluid component from the blood.. ... Pennsy Corporation

11/30/17 / #20170342124

Universal immune receptor expressed by t cells for the targeting of diverse and multiple antigens

The invention provides compositions and methods for adoptive t cell therapy in treating a variety of disorders including cancer, infections, and autoimmune disorders. In one embodiment, the invention provides a universal immune receptor (univir) that comprises an extracellular label binding domain, a transmembrane domain, and a cytoplasmic domain or otherwise an intracellular domain.. ... Pennsy Corporation

11/23/17 / #20170335395

A parkinson's disease diagnostic biomarker panel

. . The present invention relates to a method of diagnosing parkinson's disease in a subject using a novel set of biomarkers. The invention further includes compositions, methods and uses of a novel set of biomarkers to assess the risk of developing parkinson's disease, to provide pre-symptomatic diagnosis of parkinson's disease, and to assess prognosis of parkinson's disease following therapeutic or other intervention.. ... Pennsy Corporation

11/23/17 / #20170335331

Altering gene expression in cart cells and uses thereof

The present invention relates to compositions and methods for generating a modified t cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group consisting of tcr α chain, tcr β chain, beta-2 microglobulin, a hla molecule, ctla-4, pd1, and fas and further comprising a nucleic acid encoding a modified t cell receptor (tcr) comprising affinity for a surface antigen on a target cell or an electroporated nucleic acid encoding a chimeric antigen receptor (car). Also included are methods and pharmaceutical compositions comprising the modified t cell for adoptive therapy and treating a condition, such as an autoimmune disease.. ... Pennsy Corporation

11/23/17 / #20170335281

Treatment of cancer using chimeric antigen receptor

The invention provides compositions and methods for treating diseases associated with expression of a cancer associated antigen as described herein. The invention also relates to chimeric antigen receptor (car) specific to a cancer associated antigen as described herein, vectors encoding the same, and recombinant t cells comprising the cars of the present invention. ... Pennsy Corporation

11/23/17 / #20170334980

Anti-properdin antibodies and uses thereof

This invention relates to selective inhibition of the alternative pathway (ap) of the complement system using an anti-properdin antibody. Specifically, the invention relates to methods of treating an ap-mediated pathology or ap-mediated condition in an individual by contacting the individual with an anti-properdin antibody.. ... Pennsy Corporation

11/23/17 / #20170333450

Compositions and methods for treating hiv-associated cognitive dysfunction

The present invention provides methods comprising treating and/or preventing cognitive dysfunction in subjects infected with hiv by administering an antioxidant inflammation modulator (aim). The present invention also provides for methods for treating and/or preventing an hiv-associated neurocognitive disorder by contacting peripheral blood monocytes of an hiv+subject with an aim.. ... Pennsy Corporation

11/23/17 / #20170332981

A method and device for magnetic resonance imaging data acquisition guided by physiologic feedback

An adaptive real-time radial k-space sampling trajectory (arks) can respond to a physiologic feedback signal to reduce motion effects and ensure sampling uniformity. In this adaptive k-space sampling strategy, the most recent signals from an ecg waveform can be continuously matched to the previous signal history, new radial k-space locations c were determined, and these mr signals combined using multi-shot or single-shot radial acquisition schemes. ... Pennsy Corporation

11/16/17 / #20170327842

Purification and purity assessment of rna molecules synthesized with modified nucleosides

This invention provides purified preparations of an rna, oligoribonucleotide, or polyribonucleotide comprising a modified nucleoside, and methods of assessing purity of purified preparations of an rna, oligoribonucleotide, or polyribonucleotide comprising a modified nucleoside.. . ... Pennsy Corporation

11/16/17 / #20170326253

Ph-sensitive peptides and their nanoparticles for drug delivery

A new nanoscale carrier made by one or more ph-sensitive peptides is provided for delivery of a biologically active substance. The peptides are composed of ph-sensitive hydrophilic and hydrophobic amino acids in the backbone. ... Pennsy Corporation

11/09/17 / #20170322141

Measuring hiv reservoirs with optical scanning

Devices, systems and methods detect latent hiv in a patient on anti-retroviral therapy (art), the method comprising using optical scanning to identify in a cell sample of the patient gag+cd4 downregulated cells as in indication of latent hiv.. . ... Pennsy Corporation

11/09/17 / #20170319700

Drug-containing implants and methods of use thereof

The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (pla) and optionally polyglycolic acid (pga). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia and other diseases and disorders, utilizing implants of the present invention.. ... Pennsy Corporation

11/09/17 / #20170319684

Novel artificial antigen presenting cells and uses thereof

The invention relates to novel artificial antigen presenting cells (aapcs). The aapc comprises at least one stimulatory ligand and at least one co-stimulatory ligand where the ligands each specifically bind with a cognate molecule on a t cell of interest, thereby mediating expansion of the t cell. ... Pennsy Corporation

11/09/17 / #20170319319

Systems and methods for mesh augmentation and prevention of incisional hernia

Techniques for mesh augmentation and prevention of incisional hernia, including systems and methods for affixing mesh to a fascial incision. A mesh strip can be integrated with one or more uni-directional fasteners. ... Pennsy Corporation

11/09/17 / #20170319058

Apparatus and methods for testing visual function and functional vision at varying luminance levels

A test of visual function and/or functional vision may be performed at varying luminance levels. A first course may be selected for a subject. ... Pennsy Corporation

10/26/17 / #20170309025

Vivo detection of egfr mutation in glioblastoma via mri signature consistent with deep peritumoral infiltration

A method, including a computer-implemented method, is provided for in vivo detection of epidermal growth factor receptor (egfr) mutation status within peritumoral edematous tissue of a patient. The method includes performing quantitative pattern analysis of magnetic resonance imaging (mri) data corresponding to mri of in vivo peritumoral edematous tissue to determine a level of spatial heterogeneity or similarity within the in vivo peritumoral edematous tissue. ... Pennsy Corporation

10/26/17 / #20170307192

Extension module with housing for electronic components

A fixture for an elongate structure includes an extension module having a housing secured therearound. The extension module includes a longitudinal body portion having first connector and a second connector. ... Pennsy Corporation

10/26/17 / #20170306416

Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof

Cancer biomarkers and methods of using them are disclosed.. . ... Pennsy Corporation

10/26/17 / #20170306354

Adeno-associated virus (aav) serotype 8 sequences, vectors containing same, and uses therefor

Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of raav particles.. ... Pennsy Corporation

10/26/17 / #20170305971

Potent compstatin analogs

Compounds comprising peptides and peptidomimetics capable of binding c3 protein and inhibiting complement activation are disclosed. These compounds display greatly improved complement activation-inhibitory activity as compared with currently available compounds. ... Pennsy Corporation

10/26/17 / #20170304825

Apparatus and methods for manufacturing a microfluidic device

A microfluidic device includes an integrated circuit and a first substrate layer having a first surface and a second surface. The first surface of the first substrate layer is connected to the integrated circuit. ... Pennsy Corporation

10/12/17 / #20170293563

Techniques for metadata processing

Techniques are described for metadata processing that can be used to encode an arbitrary number of security policies for code running on a processor. Metadata may be added to every word in the system and a metadata processing unit may be used that works in parallel with data flow to enforce an arbitrary set of policies. ... Pennsy Corporation

10/12/17 / #20170292132

Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof

Described herein are synonymously altered gene sequences which express protein in differing levels within secretory as compared to non-secretory target tissue. An expression cassette comprising an open reading frame (orf) for a protein under the control of regulatory sequences which direct expression of the product in cell, which orf has been modified to preferentially increase expression levels in a selected tissue, wherein the modified orf is characterized by a triplet frequency of any one of tables 3-12, 16 or 17.. ... Pennsy Corporation

10/12/17 / #20170291954

Glypican-3 antibody and uses thereof

The present invention relates to compositions and methods of isolated polynucleotides that encode or polypeptides comprising glypican-3 (gpc3). The invention also includes a chimeric antigen receptor (car) wherein the car is able to target gpc3. ... Pennsy Corporation

10/12/17 / #20170290858

Altering gene expression in modified t cells and uses thereof

The present invention relates to compositions and methods for generating a modified t cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group consisting of tcr α chain, tcr β chain, beta-2 microglobulin and fas further comprising a nucleic acid encoding a modified t cell receptor (tcr) comprising affinity for a surface antigen on a target cell or an electroporated nucleic acid encoding a chimeric antigen receptor (car). Also included are methods and pharmaceutical compositions comprising the modified t cell for adoptive therapy and treating a condition, such as an autoimmune disease.. ... Pennsy Corporation

10/05/17 / #20170285124

Edema invariant tractography

Edema invariant tractography methods are provided. The methods include acquiring data using a multishell, high angular resolution diffusion imaging sequence; (ii) modeling the data using a multi-compartment model; and (iii) reconstructing the fibers through a probabilistic tracking algorithm using a fiber orientation distribution which has streamlines fitted to the output of said probabilistic tracking algorithm.. ... Pennsy Corporation

10/05/17 / #20170283775

Compositions and methods for treatment of cancer

The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified t cell to express a car wherein the car comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a cd3 zeta signaling domain.. ... Pennsy Corporation

10/05/17 / #20170281793

Anti-tem1 antibodies and uses thereof

The invention relates to anti-tem 1 antibodies or antigen-binding fragments thereof, yeast libraries comprising the same, and prophylactic, diagnostic, and therapeutic methods using the same.. . ... Pennsy Corporation

10/05/17 / #20170281691

Methods for constructing antibiotic resistance free vaccines

The present invention provides listeria vaccine strains that express a heterologous antigen and a metabolic enzyme, and methods of generating same.. . ... Pennsy Corporation

09/28/17 / #20170275686

Methods for detecting genomic dna methylation

The presently disclosed subject matter provides high-throughput methods for performing genomic dna methylation assessments. The presently disclosed subject matter further provides methods for diagnosing a subject with a disease and/or disorder, and for determining the prognosis of a subject that has a disease and/or disorder. ... Pennsy Corporation

09/28/17 / #20170275252

Asymmetric bisaminoquinolines and bisaminoquinolines with varied linkers as autophagy inhibitors for cancer and other therapy

The invention provides novel asymmetric and symmetric bisaminoquinolmes and related compounds, methods of treatment and syntheses. The novel compounds exhibit effective anticancer activity and are useful in the treatment of a variety of autophagy-related disorders.. ... Pennsy Corporation

09/28/17 / #20170274014

Combinations of low, immune enhancing, doses of mtor inhibitors and cars

The invention relates, in part, to a method of treating a subject comprising administering to the subject a low, immune enhancing of a mtor inhibitor and an immune effector cell engineered to express a car.. . ... Pennsy Corporation

09/21/17 / #20170266406

Nasal air jet insufflator

The present invention provides an apparatus for nasally delivering a supraglottic jet ventilation and methods of treating breathing disorders by utilizing the apparatus for nasally delivering a supraglottic jet ventilation.. . ... Pennsy Corporation

09/21/17 / #20170266282

Dna antibody constructs and method of using same

Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. ... Pennsy Corporation

09/14/17 / #20170261508

Methods for monitoring cd4+ t-helper type 1 response in cancer and immune restoration

A method for diagnosing or treating a mammalian subject having, or at risk of developing cancer, comprising: generating a circulating anti-cancer cd4+ th1 response from antigen presenting cells or their precursors and cd4+ t-cells from a sample of said subject's blood which causes secretion of interferon-gamma (“ifn-γ”); and detecting said anti-cancer cd4+ th1 response to determine if said response is depressed. A method for restoring her2-specific cd4+ th1 immune response in a her2-positive breast cancer patient in need thereof, comprising: administering to said patient a therapeutically effective amount of a dendritic cell (“dc”) vaccine comprising autologous dcs pulsed with her2-derived mhc class ii binding peptides (“dc vaccination”) to elevate said patient's anti-her2 cd4+ th1 response, and measuring said anti-her2 th1 response of said patient pre- and post-dc vaccination to determine the amount of increase in said response.. ... Pennsy Corporation

09/14/17 / #20170260347

Nanocomposite films and methods for producing the same

A method of producing a nanocomposite film includes generating a bilayer film including at least a first layer of at least one nanoparticle and a second layer of at least one material and annealing the bilayer film. A uniform nanocomposite film includes a plurality of nanoparticles dispersed in a polymer matrix, wherein the plurality of nanoparticles form at least 60% by volume of the polymer nanocomposite film.. ... Pennsy Corporation

09/14/17 / #20170260221

Ruthenium-based photolinkers and methods of use

The present invention provides ruthenium-based photolinker compounds, caged molecules comprising the ruthenium-based photolinker compounds, and methods of use. In certain aspects, the compositions disclosed herein comprise an active domain conjugated to a ruthenium-based photolinker, such that irradiation of the photolinker exposes the active domain.. ... Pennsy Corporation

09/14/17 / #20170258921

Protease triggered release of molecules from hydrogels

The invention relates to compositions comprising (i) biocompatible hydrogel and (ii) one or more therapeutic agents contained within said hydrogel; wherein the hydrogel is cross-linked utilizing a cross-linker comprising a peptide sequence that is capable of being degraded by an enzyme; the therapeutic agent being effective as a treatment of a condition related to the presence of the enzyme.. . ... Pennsy Corporation

09/14/17 / #20170258836

Compositions and methods of stimulating and expanding t cells

The present invention includes a method for expanding a population of electroporated t cells. The method includes electroporating a population of cells comprising t cells with mrna encoding a chimeric membrane protein comprising an antigen binding domain to a molecule and an intracellular domain of a co-stimulatory molecule, wherein the cultured t cells expand at least 10 fold. ... Pennsy Corporation

09/14/17 / #20170258835

Methods and compositions for modified t cells

The present invention relates to compositions and methods for generating modified cells with nucleic acid encoding a t cell receptor (tcr), a nucleic acid encoding a bispecific antibody, affinity molecule chimeric receptor, bispecific affinity molecule, or a chimeric ligand engineered activation receptor (clear). One aspect includes a method for generating a modified t cell. ... Pennsy Corporation

09/14/17 / #20170258821

Use of secoisolariciresinol diglucosides (sdgs) and related compounds for protection against radiation and chemical damage

The invention provides compositions and methods for radioprotection and chemoprevention using therapeutic and prophylactics methods of using (s,s)-sdg (r,r)-sdg, (s,r)-sdg (r,s)-sdg, sdg, seco, el, ed, analogs thereof, stereoisomers thereof and other related molecules.. . ... Pennsy Corporation

09/14/17 / #20170258776

Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side effects

The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an effective amount of an mtp inhibitor to inhibit hyperlipidemia and/or hypercholesterolemia in said subject, wherein said administration comprises an escalating series of doses of the mtp inhibitor. In some embodiments the method comprises administering at least three step-wise, increasing dosages of the mtp inhibitor to the subject. ... Pennsy Corporation

09/07/17 / #20170254796

Ultra low capacitance glass supported dielectric membranes for macromolecular analysis

Provided are suspended solid-state membranes on glass chips with improved capacitance. Also provided are related methods of fabricating and using the disclosed chips.. ... Pennsy Corporation

09/07/17 / #20170254740

Situ tribometer and methods of use

Techniques for determining a characteristic of a sample using an atomic force microscope including a cantilever having a probe attached thereto, including positioning the sample within a cell and sliding the probe over a sliding zone of the sample within the cell. Lateral and vertical deformations of the cantilever are detected using the atomic force microscope as the probe is slid over the sliding zone. ... Pennsy Corporation

09/07/17 / #20170253876

Transcriptome in vivo analysis (tiva) and transcriptome in situ analysis (tisa)

Compositions and methods of capturing one or more nucleic acid molecules of a cell or subcellular compartment are described. In certain aspects, the compositions comprise a caged molecule comprising one or more photolinkers and an antisense oligonucleotide, which when uncaged hybridizes to a target nucleic acid molecule.. ... Pennsy Corporation

08/31/17 / #20170247413

Compstatin analogs with improved pharmacokinetic properties

Compounds comprising peptides capable of binding c3 protein and inhibiting complement activation are disclosed. The compounds comprise compstatin analogs in which the n-terminus contains an added or substituted component that improves (1) the peptide's binding affinity to c3 or its fragments, (2) the peptide's solubility in aqueous liquids, (3) the peptide's plasma stability, (4) the peptide's in vivo retention and/or (5) the peptide's bioavailability, as compared with an unmodified compstatin peptide under equivalent conditions. ... Pennsy Corporation

08/31/17 / #20170246690

Stabilizing agent-free metal nanoparticle synthesis and uses of metal nanoparticles synthesized therefrom

Described herein are methods of synthesizing metal nanoparticles and the metal nanoparticles synthesized therefrom. Further described in the present disclosure are methods of modifying the surfaces of metal nanoparticles and the metal nanoparticles modified thereby. ... Pennsy Corporation

08/24/17 / #20170240921

A method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby

Adeno-associated virus rh.20 sequences, vectors containing same, and methods of use are provided.. . ... Pennsy Corporation

08/24/17 / #20170240630

Human alpha-folate receptor chimeric antigen receptor

The invention provides compositions and methods for treating ovarian cancer. Specifically, the invention relates to administering a genetically modified t cell having α-folate receptor (frα) binding domain and cd27 costimulatory domain to treat ovarian cancer. ... Pennsy Corporation

08/24/17 / #20170239324

Antigen-binding proteins comprising recombinant protein scaffolds

Disclosed herein are recombinant protein scaffolds and recombinant multifunctional protein scaffolds for use in producing antigen-binding proteins in addition, nucleic acids encoding such recombinant protein scaffolds, recombinant multifunctional protein scaffolds, and antigen-binding proteins are provided vectors and cells useful for expression of the described proteins are also provided, as are methods of use.. . ... Pennsy Corporation

08/24/17 / #20170239294

Compositions and methods for treating b-lymphoid malignancies

Compositions and methods for inhibiting, treating, and/or preventing a b-cell neoplasm are provided.. . ... Pennsy Corporation

08/17/17 / #20170236955

Method for making ferroelectric material thin films

A method of growing a fe material thin film using physical vapor deposition by pulsed laser deposition or rf sputtering is disclosed. The method involves creating a target to be used for the pulsed laser deposition in order to create a kbnno thin film. ... Pennsy Corporation

08/17/17 / #20170236518

System and method for multi-user gpu-accelerated speech recognition engine for client-server architectures

Disclosed herein is a gpu-accelerated speech recognition engine optimized for faster than real time speech recognition on a scalable server-client heterogeneous cpu-gpu architecture, which is specifically optimized to simultaneously decode multiple users in real-time. In order to efficiently support real-time speech recognition for multiple users, a “producer/consumer” design pattern is applied to decouple speech processes that run at different rates in order to handle multiple processes at the same time. ... Pennsy Corporation

08/17/17 / #20170236516

System and method for audio-visual speech recognition

Disclosed herein is method of performing speech recognition using audio and visual information, where the visual information provides data related to a person's face. Image preprocessing identifies regions of interest, which is then combined with the audio data before being processed by a speech recognition engine.. ... Pennsy Corporation

08/17/17 / #20170236057

System and method for face detection and landmark localization

Disclosed herein is a deep learning model that can be used for performing speech or image processing tasks. The model uses multi-task training, where the model is trained for at least two inter-related tasks. ... Pennsy Corporation

08/17/17 / #20170234795

Apparatus and methods for analyzing the output of microfluidic devices

Microfluidic devices for analyzing droplets are disclosed. A described microfluidic device includes a substrate and a microfluidic channel formed on the substrate. ... Pennsy Corporation

08/17/17 / #20170232100

Vaccines having an antigen and interleukin-21 as an adjuvant

Disclosed herein is a vaccine comprising an antigen and il-21. Also disclosed herein are methods for increasing an immune response in a subject. ... Pennsy Corporation

08/17/17 / #20170231533

Systems and methods for joint activity monitoring

Joint analysis system for analyzing kinematics of an anatomical including a sensor device, a storage device, a magnet, and an analysis engine. The sensor device can be configured to be disposed on a first side of the joint and can have one or more sensors, a processor coupled to the one or more sensors, a wireless data transmitter coupled to the processor, a data storage device coupled to the processor, and a battery coupled to the sensors, processor, wireless data transmitter, and data storage device. ... Pennsy Corporation

08/10/17 / #20170229043

Methods and devices for modeling the eye

The presently disclosed subject provides a biomimetic eye model, and methods of its production and use. In one exemplary embodiment, the biomimetic eye model can include a scaffold having a convex curvature, a fluidic device coupled to the scaffold, a fabricated eyelid coupled to the fluidic device and a motor coupled to the fabricated eyelid. ... Pennsy Corporation

08/10/17 / #20170227619

Chemical exchange saturation transfer (cest) imaging of lactate (latest)

Cest imaging technique and mr scanning are used as an mri method for detecting levels of lactate in vivo by exploiting the exchange of —oh protons on lactate with bulk water. In accordance with this method, one first obtains a lactate cest mri map of a slice of the body of a patient. ... Pennsy Corporation

08/10/17 / #20170227541

Methods for using exosomes to monitor transplanted organ status

This present disclosure relates to the use of donor organ-derived microvesicles to monitor the status of a transplanted organ in a subject. Accordingly, this disclosure provides for methods and kits for isolating, purifying and/or identifying donor organ-derived microvesicles from a biological sample of a subject. ... Pennsy Corporation

08/03/17 / #20170222576

Electrostatic clutch

An electrostatic clutch is described comprising a plurality of micron-scale thickness electrodes, adjacent electrodes being separated by a thin film of dielectric material. A power source and controller apply a voltage across two electrodes, causing an electrostatic force to develop. ... Pennsy Corporation

08/03/17 / #20170218379

Compositions and methods for self-regulated inducible gene expression

A self-regulating gene expression construct comprises a single promoter in operative association with a repressor sequence (e.g., bacterial repressor laci or gair), operator sequence(s) responsive to the expressed repressor protein, and a transgene. A dual-regulating construct comprises a single promoter controlling expression of a bacterial repressor sequence and a transgene, and which, in the presence of a first inducer molecule, transcribes the transgene and repressor; and a ribozyme in association with an aptamer sequence, the aptamer sequence capable of interacting with a second inducer molecule to terminate mrna degradation by the ribozyme. ... Pennsy Corporation

08/03/17 / #20170218378

Targeted protein replacement for the treatment of lysosomal storage disorders

The present invention relates to compositions and methods for delivering lysosomal proteins. The compositions and methods described herein permit the targeted delivery of exogenous lysosomal proteins to cell surface proteins that allow their internalization via non-clathrin pathways. ... Pennsy Corporation

08/03/17 / #20170218167

Polymer composite with liquid phase metal inclusions

Disclosed herein is a composite comprising an elastomer with an embedded network of liquid metal inclusions. The composite retains similar flexibility to that of an elastomer but exhibits electrical and thermal properties that differ from the properties of a homogeneous elastomer. ... Pennsy Corporation

08/03/17 / #20170217882

Antivirals against molluscum contagiosum virus

This invention provides compounds of formulas (i)-(xiv) as defined in the specification, and pharmaceutical compositions comprising the same, and methods of inhibiting, treating, or abrogating a molluscum contagiosum virus infection in a subject using compounds or compositions of the invention:. . ... Pennsy Corporation

08/03/17 / #20170217139

Composition, system, and method for rigidity tuning with conductive thermoplastic elastomer

Disclosed herein is a composite comprising a conductive elastomer and an isolating elastomer. When a current is passed through the conductive elastomer, its tensile modulus decreases as the elastomer heats from internal joule heating, changing the rigidity of the composite. ... Pennsy Corporation

08/03/17 / #20170216421

Manufacturing of multi-dose injection ready dendritic cell vaccines, combination therapies for blocking her2 and her3, and estrogen receptor positive her2 breast receptor positive her2 breast cancer therapy

The present embodiments relate to an fda-approved injectable multi-dose antigen pulsed dendritic cell (dc) vaccine. In one embodiment, the activated antigen-loaded dc vaccine comprises an initial immunizing dose and multiple “booster” doses. ... Pennsy Corporation

08/03/17 / #20170216419

Compositions and methods for cancer immunotherapy

The invention provides compositions and methods for cancer immunotherapy. Specifically, the invention provides an antigen-presenting cell, for example, a dendritic cell that comprises a tumor mitochondrial molecule or a tumor mitochondrial molecule derived from tumor mitochondrial protein lysate or a specific mitochondria derived protein of mitochondrial protein lysate as antigen source.. ... Pennsy Corporation

07/27/17 / #20170213690

Charged particle system and methods for irradiating a planning target volume

A method for irradiating a planning target volume with charged particles includes delivering the charged particles to the planning target volume with a charged particle therapy system including a charged particle beam path and a gantry configured to rotate about the planning target volume and to direct the charged particle beam path; rotating the gantry, during an irradiation session, to a plurality of positions; during the rotation, irradiating the planning target volume with the charged particles at a first energy level at one or more of the plurality of positions.. . ... Pennsy Corporation

07/27/17 / #20170212529

Multi-sensor fusion for robust autonomous flight in indoor and outdoor environments with a rotorcraft micro-aerial vehicle (mav)

The subject matter described herein includes a modular and extensible approach to integrate noisy measurements from multiple heterogeneous sensors that yield either absolute or relative observations at different and varying time intervals, and to provide smooth and globally consistent estimates of position in real time for autonomous flight. We describe the development of the algorithms and software architecture for a new 1.9 kg mav platform equipped with an imu, laser scanner, stereo cameras, pressure altimeter, magnetometer, and a gps receiver, in which the state estimation and control are performed onboard on an intel nuc 3rd generation i3 processor. ... Pennsy Corporation

07/27/17 / #20170211055

Sortase synthesized chimeric antigen receptors

Sortase molecules and methods described herein allow for the construction of a car or car member, e.g., in situ, on a carx, e.g., cart, cell. For example, sortase mediated transfer of an antigen binding domain, e.g., a scfv, onto a car member having a sortase acceptor motif in place of an antigen binding domain can provide for a complete car member on a cell wherein the cell does not comprise nucleic acid that encodes the complete car member.. ... Pennsy Corporation

07/27/17 / #20170210766

Silicon-based cross coupling agents and methods of their use

Compositions and methods using silicon-based cross-coupling agents in the formation of carbon-carbon and carbon-nitrogen bonds are described.. . ... Pennsy Corporation

07/27/17 / #20170209492

Subset-optimized chimeric antigen receptor-containing t-cells

This disclosure provides, for instance subset-optimized cart cells and related methods. For instance, the disclosure describes methods and compositions of cd4′ and cd8′ t cells that express cars containing specific combinations of intracellular signaling domains can be used to increase persistence and anti-tumor activity of the infused car-expressing t cells for treating a subject having a disease, e.g., a cancer.. ... Pennsy Corporation








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