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Precision Biosciences Inc patents


Recent patent applications related to Precision Biosciences Inc. Precision Biosciences Inc is listed as an Agent/Assignee. Note: Precision Biosciences Inc may have other listings under different names/spellings. We're not affiliated with Precision Biosciences Inc, we're just tracking patents.

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Self-limiting viral vectors encoding nucleases

Disclosed herein are viral vectors for use in recombinant molecular biology techniques. In particular, the present disclosure relates to self-limiting viral vectors comprising genes encoding site-specific endonucleases as well as recognition sequences for site-specific endonucleases such that expression of the endonuclease in a cell cleaves the viral vector and limits its persistence time. ... Precision Biosciences Inc

Methods and products for producing engineered mammalian cell lines with amplified transgenes

Methods of inserting genes into defined locations in the chromosomal dna of cultured mammalian cell lines which are subject to gene amplification are disclosed. In particular, sequences of interest (e.g., genes encoding biotherapeutic proteins) are inserted proximal to selectable genes in amplifiable loci, and the transformed cells are subjected to selection to induce co-amplification of the selectable gene and the sequence of interest. ... Precision Biosciences Inc

Genetically-modified cells comprising a modified human t cell receptor alpha constant region gene

Disclosed herein is a genetically-modified cell comprising in its genome a modified human t cell receptor alpha constant region gene, wherein the cell has reduced cell-surface expression of the endogenous t cell receptor. The present disclosure further relates to methods for producing such a genetically-modified cell, and to methods of using such a cell for treating a disease in a subject.. ... Precision Biosciences Inc

Genetically-modified cells comprising a modified human t cell receptor alpha constant region gene

Disclosed herein is a genetically-modified cell comprising in its genome a modified human t cell receptor alpha constant region gene, wherein the cell has reduced cell-surface expression of the endogenous t cell receptor. The present disclosure further relates to methods for producing such a genetically-modified cell, and to methods of using such a cell for treating a disease in a subject.. ... Precision Biosciences Inc

Genetically-modified cells comprising a modified human t cell receptor alpha constant region gene

Disclosed herein is a genetically-modified cell comprising in its genome a modified human t cell receptor alpha constant region gene, wherein the cell has reduced cell-surface expression of the endogenous t cell receptor. The present disclosure further relates to methods for producing such a genetically-modified cell, and to methods of using such a cell for treating a disease in a subject.. ... Precision Biosciences Inc

Genetically-modified cells comprising a modified human t cell receptor alpha constant region gene

Disclosed herein is a genetically-modified cell comprising in its genome a modified human t cell receptor alpha constant region gene, wherein the cell has reduced cell-surface expression of the endogenous t cell receptor. The present disclosure further relates to methods for producing such a genetically-modified cell, and to methods of using such a cell for treating a disease in a subject.. ... Precision Biosciences Inc

Dystrophin gene exon deletion using engineered nucleases

The invention relates to the field of molecular biology and recombinant nucleic acid technology. In particular, the invention relates to methods of treating patients with duchenne muscular dystrophy comprising the removal of at least one exon from the dystrophin gene using engineered nucleases to restore the normal reading frame. ... Precision Biosciences Inc








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