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Quest Diagnostics Investments Incorporated patents


Recent patent applications related to Quest Diagnostics Investments Incorporated. Quest Diagnostics Investments Incorporated is listed as an Agent/Assignee. Note: Quest Diagnostics Investments Incorporated may have other listings under different names/spellings. We're not affiliated with Quest Diagnostics Investments Incorporated, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "Q" | Quest Diagnostics Investments Incorporated-related inventors


Thyroglobulin quantitation by mass spectroscopy

Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide t129, purifying peptide t129, ionizing peptide t129, detecting the amount of peptide t129 ion generated, and relating the amount of peptide t129 ion to the amount of thyroglobulin originally present in the sample.. ... Quest Diagnostics Investments Incorporated

Cystic fibrosis transmembrane conductance regulator gene mutations

The present invention provides novel mutations of the cftr gene related to cystic fibrosis or to conditions associated with cystic fibrosis. Also provided are probes for detecting the mutant sequences. ... Quest Diagnostics Investments Incorporated

Systems and methods for administration of prescription drug benefits

The invention relates to the administration of prescription drug formulary information. A list of drugs that a particular prescription drug plan will pay for in whole or in part is called a formulary. ... Quest Diagnostics Investments Incorporated

Systems and methods for electronically distributing information

Embodiments of the invention include systems and methods for transmitting messages related to certain information while maintaining the confidentiality of that information. A potential recipient may register one or more devices for receipt of such messages while specifying rules regarding when different messages may be delivered to the various devices. ... Quest Diagnostics Investments Incorporated

Circulating microrna as a marker for hepatocellular carcinoma

Provided herein are methods for the diagnosis, or management of liver diseases, e.g., hepatocellular carcinoma, using profiles of the mirnas determined from cellular or acellular body fluids.. . ... Quest Diagnostics Investments Incorporated

Methods for detecting vitamin d metabolites by mass spectrometry

Provided are methods of detecting the presence or amount of a vitamin d metabolite in a sample using mass spectrometry. The methods generally directed to ionizing a vitamin d metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin d metabolite in the sample. ... Quest Diagnostics Investments Incorporated

Kisspeptin-54 detection by tandem mass spectrometry

Methods are described for measuring the amount of a kisspeptin-54-derived peptides in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying a kisspeptin-54 derived peptides in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.. ... Quest Diagnostics Investments Incorporated

Compositions and methods for screening solid tumors

The present technology relates to methods for determining whether a patient diagnosed with breast cancer, colorectal cancer, melanoma or lung cancer will benefit from or is predicted to be responsive to treatment with an individual therapeutic agent or a specific combination of therapeutic agents. These methods are based on screening a patient's solid tumors and detecting alterations in target nucleic acid sequences corresponding to a specific set of cancer-related genes. ... Quest Diagnostics Investments Incorporated

Methods and devices for detecting hepatitis c virus

The present disclosure provides rapid and non-invasive methods for determining whether a patient will benefit from treatment with therapeutic agents that inhibit hepatitis c virus (hcv). These methods are based on detecting hcv rna and/or anti-hcv antibodies in small-volume dried biological fluid samples that are collected using a microsampling device. ... Quest Diagnostics Investments Incorporated

Methods for detecting dna mutations using mitra tip extraction

The present disclosure provides rapid and non-invasive methods for determining whether a patient exhibiting cancer symptoms, or at risk for hereditary cancers such as breast cancer, ovarian cancer, colon cancer, or skin cancer, will benefit from treatment with one or more therapeutic agents. These methods are based on detecting hereditary cancer-related mutations in small-volume dried biological fluid samples that are collected using a volumetric absorptive microsampling device (e.g., mitra tip). ... Quest Diagnostics Investments Incorporated

Methods for detecting cystic fibrosis mutations using mitra tip extraction

The present disclosure provides methods for determining whether a patient exhibiting cystic fibrosis symptoms, or a patient at risk for cystic fibrosis, will benefit from treatment with one or more anti-cystic fibrosis therapeutic agents. These methods are based on detecting hereditary cystic fibrosis related mutations in small-volume dried biological fluid samples that are collected using a volumetric absorptive microsampling device. ... Quest Diagnostics Investments Incorporated

Quantitation of insulin-like growth factor-i and insulin-like growth factor-ii with high-resolution mass spectrometry

Methods are provided for determining the amount of an igf-i and/or igf-ii protein in a sample using high resolution/high accuracy mass spectrometry. The methods generally comprise enriching an igf-i and/or igf-ii protein in a sample, ionizing an igf-i and/or igf-ii protein from the sample to generate igf-i and/or igf-ii protein ions, and determining the amount of igf-i and/or igf-ii protein ions with high resolution/high accuracy mass spectrometry.. ... Quest Diagnostics Investments Incorporated

Cystic fibrosis gene mutations

. . The present invention provides novel mutations of the cftr gene related to cystic fibrosis or to conditions associated with cystic fibrosis. Also provided are probes for detecting the mutant sequences. ... Quest Diagnostics Investments Incorporated

Compositions and methods for determining endometrial cancer prognosis

The present invention provides methods and compositions for determining prognosis in individual with cancer, in particular endometrial cancer. The present invention also provides methods of developing and using predictive models that are useful for determining prognosis of endometrial cancer and other similar diseases. ... Quest Diagnostics Investments Incorporated

02/22/18 / #20180051329

Alignment and variant sequencing analysis pipeline

Provided are systems and methods for analyzing genetic sequence data from next generation sequence (ngs) platforms. Also provided are methods for the preparation of samples for nucleic acid sequence analysis by ngs. ... Quest Diagnostics Investments Incorporated

02/15/18 / #20180045743

Mass spectrometric quantitation assay for metabolites of leflunomide

Methods are described for determining the amount of metabolites of leflunomide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying teriflunomide in a sample.. ... Quest Diagnostics Investments Incorporated

02/08/18 / #20180037938

Kits for detecting mycobacterium avium/intracellulare nucleic acid

Disclosed is a method for determining the presence of mycobacterium avium complex nucleic acids in a biological sample. In particular, the mig gene of m. ... Quest Diagnostics Investments Incorporated

02/01/18 / #20180031561

Mpl mutations in jak2 v617f negative patients with myeloproliferative disease

The invention provides compositions and methods for diagnosing a patient as having a myeloproliferative disease by identifying mutations in the mpl gene or gene products.. . ... Quest Diagnostics Investments Incorporated

01/25/18 / #20180024151

Mass spectrometric determination of eicosapentaenoic acid and docosahexaenoic acid

The invention relates to the detection of dha and epa. In a particular aspect, the invention relates to methods for detecting dha and epa by mass spectrometry and kits for carrying out such methods.. ... Quest Diagnostics Investments Incorporated

01/25/18 / #20180023145

Nucleic acid detection combining amplification with fragmentation

Provided herein are methods and compositions for detection of a nucleic acid target in a sample. The methods and compositions use primer directed amplification in conjunction with nucleic acid fragmentation. ... Quest Diagnostics Investments Incorporated

01/11/18 / #20180011117

Lipoprotein analysis by differential charged-particle mobility

The invention provides methods of preparation of lipoproteins from a biological sample, including hdl, ldl, lp(a), idl, and vldl, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. ... Quest Diagnostics Investments Incorporated

01/04/18 / #20180003714

Bcr-abl variants

A splice variant of bcr-abl mrna that produces bcr-abl protein with a truncated c-terminus and its role in resistance to treatment with kinase inhibitors is disclosed. Vectors for expressing the truncated gene product are provided as well as recombinant cells that express the truncated gene product from a cdna construct. ... Quest Diagnostics Investments Incorporated

11/30/17 / #20170342402

Diagnosis of prostate cancer

The invention provides methods for isolating rna from whole urine and urine fractions for the diagnosis of prostate cancer and/or benign prostate hyperplasia. An exemplary method for diagnosing prostate cancer in an individual, said method comprises: (a) determining the amount of rna encoding one or more diagnostic genes in the soluble urine fraction of a urine sample obtained from said individual; (b) comparing the amount of said rna to a reference value for said one or more diagnostic genes, wherein said reference value is derived from the amount of rna encoding said one or more diagnostic genes in one or more individuals that do not have prostate cancer; and (c) diagnosing said individual as having prostate cancer when the amount of said rna is greater than said reference value.. ... Quest Diagnostics Investments Incorporated

11/23/17 / #20170337331

Graphical presentation of medical data

Methods and user interfaces are provided for the display of data comprising series of data over time, with particular application to medical laboratory results and prescriptions of medication. A user may view multiple results simultaneously in a single display, with the abilities to zoom the time scale in and out and to select the time period for which results are displayed. ... Quest Diagnostics Investments Incorporated

10/26/17 / #20170306410

Bcr-abl1 splice variants and uses thereof

The present invention is based on bcr-abl1 splice variants which result from insertion and/or truncation of the bcr-abl1 transcript and the finding that these variants provide resistance to kinase domain inhibitors such as imatinib, nilotinib and dasatinib.. . ... Quest Diagnostics Investments Incorporated

10/12/17 / #20170292868

Device and method for evaluating amount of biological sample in a specimen container

An apparatus and method are provided to evaluate an amount of a biological sample in a specimen container. A fixture has a bottom surface configured to support a specimen container. ... Quest Diagnostics Investments Incorporated

10/05/17 / #20170287688

Methods of detecting reverse triiodothyronine by mass spectrometry

Provided are methods for determining the amount of reverse t3 in a sample using mass spectrometry. The methods generally involve ionizing reverse t3 in a sample and detecting and quantifying the amount of the ion to determine the amount of reverse t3 in the sample.. ... Quest Diagnostics Investments Incorporated

09/28/17 / #20170275693

Nucleic acid analysis using emulsion pcr

The present invention provides methods for analyzing large nucleic acids including chromosomes and chromosomal fragments. In one aspect, the present invention provides a method of nucleic acid analysis comprising the steps of (a) obtaining a sample of nucleic acid comprising at least one chromosome or fragment greater than about 1 000 base pairs in length and containing a target region; (b) creating an emulsion in which each drop of the emulsion contains an average of between about 0-2, 0-1.75, 0-1.5, 0-1.0, 0-0.75, 0-0.5, or fewer chromosomes or fragments of step (a), (c) performing emulsion pcr, (d) quantifying the number of emulsion droplets containing amplified nucleic acid from the target region; (e) calculating the ratio of droplets containing amplified nucleic acid from the target region to total droplets; and (f) comparing the ratio of step (e) to a reference ratio representing a known genotype.. ... Quest Diagnostics Investments Incorporated

09/21/17 / #20170269107

Methods for detecting estrone by mass spectrometry

Provided are methods for determining the amount of estrone in a sample using mass spectrometry. The methods generally involve ionizing estrone in a sample and detecting and quantifying the amount of the ion to determine the amount of estrone in the sample.. ... Quest Diagnostics Investments Incorporated

09/14/17 / #20170262166

Visual presentation of multi-dimensional data sets

Computer systems and methods may display multi-dimensional data sets in a dynamically-generated ocular view, which may show the relationship between data points in the different dimensions. For example, such a data set may include in one dimension results of one or more laboratory tests and, in another dimension, body systems or functions that the respective tests may relate to. ... Quest Diagnostics Investments Incorporated

09/14/17 / #20170261523

Mass spectrometry of steroidal compounds in multiplexed patient samples

The invention relates to the quantitative measurement of steroidal compounds by mass spectrometry. In a particular aspect, the invention relates to methods for quantitative measurement of steroidal compounds from multiple samples by mass spectrometry.. ... Quest Diagnostics Investments Incorporated

09/14/17 / #20170260591

Ddr2 mutations as targetable features of melanoma or basal cell carcinoma

Described herein are methods for diagnosing melanoma or basal cell carcinoma based on mutations in the ddr2 gene. Further, a distinct subgroup of braf-mutated melanomas have somatic mutations in the ddr2 gene as well. ... Quest Diagnostics Investments Incorporated

08/31/17 / #20170248620

Vitamin d metabolite determination utilizing mass spectrometry following derivatization

The invention relates to the detection of vitamin d metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin d metabolites by mass spectrometry.. ... Quest Diagnostics Investments Incorporated

08/24/17 / #20170242044

Methods for detecting vitamin c by mass spectrometry

Provided are methods for determining the amount of vitamin c in a sample using mass spectrometry. The methods generally involve ionizing vitamin c in a sample and detecting and quantifying the amount of the ion to determine the amount of vitamin c in the sample.. ... Quest Diagnostics Investments Incorporated

07/27/17 / #20170212127

C peptide detection by mass spectrometry

. . Methods are described for measuring the amount of c peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying c peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.. ... Quest Diagnostics Investments Incorporated

07/06/17 / #20170191116

Method for direct microbial identification

Described herein are methods for direct detection of microbial agent(s) in a polymicrobial sample, such as a biological sample from a human, without culturing the microbial agent(s). The direct detection can identify mixtures of bacteria and/or fungi in the sample. ... Quest Diagnostics Investments Incorporated

06/22/17 / #20170176452

Thyroglobulin quantitation by mass spectroscopy

Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide t129, purifying peptide t129, ionizing peptide t129, detecting the amount of peptide t129 ion generated, and relating the amount of peptide t129 ion to the amount of thyroglobulin originally present in the sample.. ... Quest Diagnostics Investments Incorporated

06/22/17 / #20170176451

Kisspeptin-54 detection by tandem mass spectrometry

Methods are described for measuring the amount of a kisspeptin-54-derived peptides in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying a kisspeptin-54 derived peptides in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.. ... Quest Diagnostics Investments Incorporated

06/22/17 / #20170175198

Discriminating braf mutations

Provided herein are methods for detecting and discriminating braf v600 mutations. Also provided herein are methods for diagnosis, prognosis, management, and treatment decisions of braf v600 mutation-related diseases or conditions.. ... Quest Diagnostics Investments Incorporated

05/18/17 / #20170137884

Bcr-abl truncation mutations

Truncation variants of bcr-abl mrna that produces bcr-abl proteins with a truncated c-terminus and its role in resistance to treatment with kinase inhibitors is described. Vectors for expressing the truncated gene products are described as well as recombinant cells that express the truncated gene products from cdna constructs. ... Quest Diagnostics Investments Incorporated

05/18/17 / #20170137867

Methods for the diagnosis of bacterial vaginosis

The present invention relates to methods for the diagnosis of bacterial vaginosis based on an analysis of a patient sample. For example, patient test samples are analyzed for the presence or absence of one or more lactobacilli and two or more pathogenic organisms. ... Quest Diagnostics Investments Incorporated

04/27/17 / #20170115314

Mass spectrometric determination of cookson-derivatized, non-metabolized vitamin d

The invention relates to the detection of vitamin d. In a particular aspect, the invention relates to methods for detecting derivatized vitamin d by mass spectrometry.. ... Quest Diagnostics Investments Incorporated

04/27/17 / #20170115312

Mass spectrometry assay for congenital adrenal hyperplasia

Methods are provided for detecting the amount of one or more cah panel analytes (i.e., pregnenolone, 17-oh pregnenolone, progesterone, 17-oh progesterone, dehydroepiandrosterone (dhea), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more cah panel analytes in a sample and quantifying the generated ions to determine the amount of one or more cah panel analytes in the sample. ... Quest Diagnostics Investments Incorporated

04/13/17 / #20170102400

Methods for detecting vitamin d metabolites by mass spectrometry

Provided are methods of detecting the presence or amount of a vitamin d metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin d metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin d metabolite in the sample. ... Quest Diagnostics Investments Incorporated

04/13/17 / #20170102368

Methods for detecting lacosamide by mass spectrometry

Provided are methods for determining the amount of lacosamide in a sample using mass spectrometry. The methods generally involve ionizing lacosamide in a sample and detecting and quantifying the amount of the ion to determine the amount of lacosamide in the sample.. ... Quest Diagnostics Investments Incorporated

03/30/17 / #20170089917

Amyloid beta detection by mass spectrometry

Provided are methods for the detection or quantitation of amyloid beta. In a particular aspect, provided herein are methods for detecting amyloid beta or fragments thereof by mass spectrometry. ... Quest Diagnostics Investments Incorporated

03/30/17 / #20170088899

Microrna profiling for diagnosis of dysplastic nevi and melanoma

Provided herein are methods for mirna profiling for the diagnosis, prognosis, and management of melanoma and differentiation of melanoma from nevi.. . ... Quest Diagnostics Investments Incorporated

03/23/17 / #20170081735

Direct amplification and detection of viral and bacterial pathogens

Provided herein are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods as-saying saying extracted nucleic acids.. . ... Quest Diagnostics Investments Incorporated

03/23/17 / #20170081725

Microrna profiling for diagnosis of dysplastic nevi and melanoma

Provided herein are methods for mirna profiling for the diagnosis, prognosis, and management of melanoma and differentiation of melanoma from nevi.. . ... Quest Diagnostics Investments Incorporated

03/16/17 / #20170073669

Rna isolation from soluble urine fractions

The invention provides methods for isolating rna from the soluble fraction of urine. The methods can be used for detecting the presence or absence of an rna, or quantifying the amount of an rna. ... Quest Diagnostics Investments Incorporated

02/23/17 / #20170049225

Workspace for performing liquid chromotography analysis

A work space apparatus for performing scientific analysis having a plurality of modules coupled to an upper region of a desk surface and a top surface coupled to and vertically above the plurality of modules. Each of the plurality of modules has a width defined by a first sidewall and second sidewall and a height that is adjustable.. ... Quest Diagnostics Investments Incorporated

02/16/17 / #20170045511

Assays and methods for the diagnosis of post-streptococcal disorders

Provided are methods for diagnosing a disease in a subject with a previous streptococcal infection by determining the presence or absence of one or more autoantibodies in a biological sample from the subject, wherein the one or more autoantibodies recognize an antigen from a protein selected from the group consisting of elavl2, elavl3, elavl4, nova-1, nova-2, cdr1, cdr2; and cdr3. The presence of such autoantibodies is indicative of a positive diagosis for a post-streptococcal disease such as pandas, post-gabhs glomerulonephritis, rheumatic fever, autism and syndenham's chorea.. ... Quest Diagnostics Investments Incorporated

01/26/17 / #20170023537

Quantitation of tamoxifen and metabolites thereof by mass spectrometry

Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein determine the amount of norendoxifen. ... Quest Diagnostics Investments Incorporated

01/26/17 / #20170022566

Cystic fibrosis transmembrane conductance regulator gene mutations

The present invention provides novel mutations of the cftr gene related to cystic fibrosis or to conditions associated with cystic fibrosis. The mutations include duplication of exons including duplication of exons 6b through 10. ... Quest Diagnostics Investments Incorporated

01/05/17 / #20170002418

Cystic fibrosis transmembrane conductance regulator gene mutations

. . The present invention provides novel mutations of the cftr gene related to cystic fibrosis or to conditions associated with cystic fibrosis. Also provided are probes for detecting the mutant sequences. ... Quest Diagnostics Investments Incorporated

01/05/17 / #20170002416

Method to detect repeat sequence motifs in nucleic acid

Methods for determining the presence or absence of expansion of cgg repeat sequence in the fmr1 gene presence or absence of expansion of ccg repeat sequence in the fmr2 gene are provided. The methods are useful in identifying an individual with normal/intermediate, versus premutation or full mutation allele of fmr1 gene and fmr2 gene due to the expansion of cgg repeats and ccg repeats in the 5′-untranslated region respectively. ... Quest Diagnostics Investments Incorporated








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