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Research Development Foundation patents


Recent patent applications related to Research Development Foundation. Research Development Foundation is listed as an Agent/Assignee. Note: Research Development Foundation may have other listings under different names/spellings. We're not affiliated with Research Development Foundation, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "R" | Research Development Foundation-related inventors


Modulation of srpx2-mediated angiogenesis

The present invention relates to nucleic acids and antibodies against srpx2 and srpx2 protein function in angiogenesis. Angiogenesis-related conditions, such as cancer or wound healing, can be treated by the composition comprising the srpx2 antagonists or agonists, respectively.. ... Research Development Foundation

Serine protease molecules and therapies

Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). ... Research Development Foundation

Jam-c antibodies and methods for treatment of cancer

A novel method to reduce b-cell lymphoma cell migration to and engraftment of the spleen in patients with jam-c positive b-cell lymphomas is described. In certain aspects, a method for identifying and treating jam-c positive b-cell lymphoma patients with anti-jam-c antibodies is provided. ... Research Development Foundation

Vaccines and diagnostics for the ehrlichioses

The present invention concerns vlpt immunoreactive compositions for e. Chaffeensis and compositions related thereto, including vaccines, antibodies, polypeptides, peptides, and polynucleotides. ... Research Development Foundation

Elimination of proliferating cells from stem cell-derived grafts

Provided herein are methods and compositions for a suicide gene approach comprising an expression vector comprising a cell cycle-dependent promoter driving the expression of a suicide gene. Also provided herein are methods to render proliferative cells sensitive to a prodrug after transplantation but avoids expression of the suicide gene in post-mitotic cells, such as neurons.. ... Research Development Foundation

Methods and compositions relating to improved lentiviral vectors and their applications

The present invention provides hiv-derived lentivectors which are safe, highly efficient, and very potent for expressing transgenes for human gene therapy, especially, in human hematopoietic progenitor cells as well as in all other blood cell derivatives. The lentiviral vectors comprise a self-inactivating configuration for biosafety and promoters such as the ef1α promoter as one example. ... Research Development Foundation

Jam-c antibodies and methods for treatment of cancer

A novel method to reduce b-cell lymphoma cell migration to and engraftment of the spleen in patients with jam-c positive b-cell lymphomas is described. In certain aspects, a method for identifying and treating jam-c positive b-cell lymphoma patients with anti-jam-c antibodies is provided. ... Research Development Foundation

Sortase-modified molecules and uses thereof

Cell-targeted cytotoxic agents, including sortase serine protease constructs, are provided. Such compounds can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). ... Research Development Foundation

Methods for generating engineered enzymes

Provided are improved methods for identifying the substrate recognition specificity or activity of a protease, convertase (sortase), or kinase. In some embodiments, methods are provided for identifying the endogenous protease or convertase cleaving patterns (e.g., “cleaveome”) inside the secretory pathway of a living cell. ... Research Development Foundation

Immunoreactive protein orthologs of ehrlichia canis and e. chaffeensis

The present invention concerns gp36 immunoreactive compositions for e. Canis and gp 47 immunoreactive compositions for e. ... Research Development Foundation

Methods for treating insulin resistance and for sensitizing patients to glp1 agonist therapy

Methods for treatment of insulin resistance and type ii diabetes by administration of inhibitors of the pki pathway are provided. In some aspects, inhibitors of the pki pathway, such as inhibitors of pikb, hif1 and/or mtor, can be used to treat subject having insulin resistance who are refractory to glp1 agonist therapy.. ... Research Development Foundation

Immunoreactive glycoprotein gp19 of ehrlichia canis

The present invention concerns gp19 immunoreactive compositions for e. Canis and compositions related thereto, including vaccines, antibodies, polypeptides, peptides, and polynucleotides. ... Research Development Foundation

Vaccines and diagnostics for the ehrlichioses

The present invention concerns vlpt immunoreactive compositions for e. Chaffeensis and compositions related thereto, including vaccines, antibodies, polypeptides, peptides, and polynucleotides. ... Research Development Foundation

Methods for treatment and prevention of tauopathies and amyloid beta amyloidosis by modulating crf receptor signaling

Methods for treating or preventing tauopathies and/or aβ amyloidosis by modulating crf receptor signaling. Accumulation of hyperphosphorlyated tau protein in the cns may be reduced by administration of crf-r1 selective antagonists and/or crf-r2 selective agonists. ... Research Development Foundation

05/04/17 / #20170122720

Apparatus and methods for optical coherence tomography and two-photon luminescence imaging

Exemplary embodiments of the present disclosure include a combined catheter-based optical coherence tomography-two-photon luminescence (oct-tpl) imaging system. Exemplary embodiments further include methods to detect, and further characterize the distribution of cellular components (e.g., macrophage, collagen/elastin fiber, lipid droplet) in thin-cap fibroatheromas with high spatial resolution in vivo.. ... Research Development Foundation

03/23/17 / #20170081377

Rtef-1 variants and the use thereof for inhibition of angiogenesis

Dominant negative (dn) variants of transcriptional enhancer factor 1-related (rtef-1) are described. Dn rtef-1 polypeptides may be directly targeted to cells or delivered in nucleic acid expression vectors to alter cellular transcription. ... Research Development Foundation

03/09/17 / #20170067079

Methods and compositions relating to restricted expression lentiviral vectors and their applications

The present invention provides hiv-derived lentivectors which are safe, highly efficient, and very potent for expressing transgenes for human gene therapy, especially, in human hematopoietic progenitor cells as well as in all other blood cell derivatives. The lentiviral vectors comprise promoters active to promote expression specific to cell types or tissues. ... Research Development Foundation

03/02/17 / #20170058030

Engineered antibody fc variants

In some aspects, mutant or variant fc domains are provided that can exhibit increased affinity or selectivity for fcγriib. The variant fc domain may be a mutant igg1 fc domain. ... Research Development Foundation

02/09/17 / #20170037091

Sty peptides for inhibition of angiogenesis

Peptides for the treatment of cancer and angiogenic disorders are provided. In some aspects, the peptides may be used to decrease angiogenesis or vegf expression or function in a cancer such as, e.g., an ocular cancer. ... Research Development Foundation








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