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Roche Diagnostics Operations Inc patents


Recent patent applications related to Roche Diagnostics Operations Inc. Roche Diagnostics Operations Inc is listed as an Agent/Assignee. Note: Roche Diagnostics Operations Inc may have other listings under different names/spellings. We're not affiliated with Roche Diagnostics Operations Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "R" | Roche Diagnostics Operations Inc-related inventors


 new patent  Identification of patients with abnormal fractional shortening

The present invention relates to a method for assessing whether a subject shall be subjected to an imaging based diagnostic assessment. The method is based on the determination of the amount(s) of a cardiac troponin and/or fibroblast growth factor 23 (fgf-23) in a sample from the subject, and on the comparison of the, thus, determined amount(s) with a reference amount (reference amounts). ... Roche Diagnostics Operations Inc

 new patent  Troponin and bnp based diagnosis of risk patients and cause of stroke

Method for determination of whether a subject suffers from intermittent atrial fibrillation based on the determination of the amount of a troponin t in a sample in a patient suffering from atrial fibrillation using a binding assay. Kits and devices adapted to carry out the methods are also provided.. ... Roche Diagnostics Operations Inc

Laboratory sample distribution system and laboratory automation system

A laboratory sample distribution system is presented. The system comprises a number of sample container carriers, a transport plane, a number of electro-magnetic actuators, a number of position sensors and a position determination unit. ... Roche Diagnostics Operations Inc

Particle-based immunoassay using a pegylated analyte-specific binding agent

Disclosed is a method for measurement of an analyte in a microparticle-based analyte-specific binding assay, wherein the microparticles are coated with the first partner of a binding pair, the method involving mixing the coated microparticles, an analyte-specific binding agent conjugated to the second partner of the binding pair, and a sample suspected of containing or containing the analyte, wherein the second partner of the binding pair is bound to the analyte-specific binding agent via a linker having from 12 to 30 ethylene glycol units (peg 12 to 30), thereby binding the analyte via the conjugated analyte-specific binding agent to the coated microparticles, separating the microparticles having the analyte bound via the binding pair and the analyte-specific binding agent from the mixture and measuring the analyte bound to the microparticles.. . ... Roche Diagnostics Operations Inc

Characterizing the emission properties of samples

The present disclosure relates to a method for characterizing a light source. The method includes providing a light source to be characterized, collecting light emitted from the light source by using imaging optics, the imaging optics generating a pupil of the collected light emitted from the light source, generating an image of a pupil of light emitted only from a first surface area of the light source at a detector using the imaging optics, laterally shifting the light source and the imaging optics relative to each other and after the lateral shift, generating an image of a pupil of light emitted only from a second surface area of the light source at the detector using the imaging optics. ... Roche Diagnostics Operations Inc

Alkaline pretreatment of parvoviruses for immunoassays

Disclosed is a method for detecting a capsid polypeptide of a non-enveloped virus in a sample from a subject which includes (a) contacting the sample with a base, and (b) detecting a capsid polypeptide of the virus in the sample. Moreover, the present disclosure relates to a method for pre-processing a sample from a subject for detection of a virus, including contacting the sample with a base. ... Roche Diagnostics Operations Inc

Laboratory sample distribution system and laboratory automation system

A laboratory sample distribution system is presented. The system comprises a number of sample container carriers to carry one or more sample containers. ... Roche Diagnostics Operations Inc

Tube rack transfer device and diagnostic instrument

A tube rack transfer device for transferring racks is presented. A first rail extends in a first horizontal direction and a second rail extends in a second horizontal direction orthogonal to the first direction. ... Roche Diagnostics Operations Inc

Supplementing measurement results of automated analyzers

A computer-implemented method for supplementing measurement results of automated analyzers is presented. The method includes obtaining, at a computer device, a result of a measurement performed by an automated analyzer, the computer device and the automated analyzer being located within a privileged computer network, obtaining a context related algorithm associated with the result of the measurement defining one or more triggering conditions and context related information from a computer device residing outside of the privileged computer network at the computer device and processing the result of the measurement by using the context related algorithm to generate a context specific supplement to the result of the measurement at the computer device.. ... Roche Diagnostics Operations Inc

Use of compounds comprising two or more hydrophobic domains and a hydrophilic domain comprising peg moieties for stabilization of a cell

The present invention relates to the use compounds comprising two or more hydrophobic domains and a hydrophilic domain comprising a polyethylene glycol (peg) moiety for stabilization of a cell, and methods related thereto.. . ... Roche Diagnostics Operations Inc

Rotatable cartridge with multiple metering chambers

A method and cartridge for determining an amount of at least two analytes in a biological sample and an automatic analyzer are disclosed. The cartridge may comprise a cartridge inlet, a sample holding chamber fluidically connected to the inlet, and two or more metering chambers. ... Roche Diagnostics Operations Inc

Sample container carrier, laboratory sample distribution system and laboratory automation system

A sample container carrier for a laboratory sample distribution system is presented. The sample container carrier comprises a magnetic element that is arranged such that a magnetic move force applied to the sample container carrier depends on an angularity. ... Roche Diagnostics Operations Inc

Inventory alert system for laboratories

Disclosed herein is a system and computer implemented method for detecting extraordinary demand of a consumable(s) for processing biological samples by laboratory instrument(s) in a plurality of laboratories based on exceptional deviations from usual demand levels of trigger laboratories in the proximity of a target laboratory.. . ... Roche Diagnostics Operations Inc

Methods for reducing interferences

The present invention relates to a method for determining an analyte in a sample suspected to comprise said analyte, comprising a) contacting with said sample at least a first and a second capture compound for said analyte, wherein said first and second capture compounds are non-identical capture compounds, and wherein said capture compounds compete in binding to said analyte; b) contacting said capture compounds contacted with said sample with a specifier, wherein said specifier competes in binding to said capture compounds with said analyte; c) determining the amount of complexes comprising said specifier and a capture compound; and d) determining said analyte in a sample based on the result of step c). The present invention further relates to a method for improving the specificity of an indirect immunoassay for determining an analyte, comprising replacing at least 10% of a capture compound by a non-identical capture compound; wherein the capture compound replaced competes in binding to said analyte with the capture compound introduced. ... Roche Diagnostics Operations Inc

05/03/18 / #20180120289

Medical instrument with shutter for sealing a test strip port

A medical instrument/analyzer for measuring a biological sample using a test strip. The instrument comprises: a housing with an exterior surface, an internal surface, and an interior volume; an analytical unit within the interior volume with a test strip mount; a test strip port between the exterior and the interior surfaces; a shutter configured for sealing the test strip port when closed, wherein the shutter comprises a test strip support aligned with the test strip port and mount when the shutter is in the open position, wherein the shutter has a first sealing surface, the test strip port has a second sealing surface, and the first sealing and second sealing surfaces are configured to mate in the closed position, wherein the shutter comprises a mechanism for moving between the open and the closed position; and an actuator configured for moving the shutter between the open and closed position.. ... Roche Diagnostics Operations Inc

04/19/18 / #20180106821

Storage module, method of operating a laboratory automation system and laboratory automation system

A storage module for a laboratory automation system, a method of operating a laboratory automation system, and a laboratory automation system are presented. Items used by laboratory stations are stored centrally in a storage module and can be transported to the laboratory stations using a laboratory sample distribution system.. ... Roche Diagnostics Operations Inc

04/19/18 / #20180105323

External packaging for safeguarding at least one package during transportation

A process for safeguarding a product during transportation comprises forming a package by surrounding a product with packaging material and accommodating the package in an external packaging that comprises a carrier element and a bag element. The carrier element includes an upper side including a border and a lower side opposite the upper side, wherein the lower side comprises a base. ... Roche Diagnostics Operations Inc

04/19/18 / #20180104683

Test element analysis system for the analytical examination of a sample

A test element analysis system for the analytical examination of a sample, a method for positioning a test element in a measuring device and a method for an analytical examination of a sample are disclosed. The test element analysis system comprises: a measurement device comprising a test element receptacle for receiving a test element at least partially, wherein the receptacle comprises a first part and a second part, the first part comprises a support surface for placement of the test element, the second part comprises an alignment pin for engagement with an alignment hole of the test element, the second part is movable relative to the first part in a direction essentially perpendicular to the support surface, the receptacle is configured to position the second part in at least three distinct positions relative to the first part comprising an intermediate position, a closed position, and an open position.. ... Roche Diagnostics Operations Inc

04/12/18 / #20180100826

Method and test element for electrochemically detecting at least one analyte in a sample of a body fluid

A method and test element for electrochemically detecting at least one analyte in a sample are provided, wherein the method comprises: a) providing at least one test element comprising at least one first electrode contacting a test chemistry and at least one second electrode, wherein a surface of the second electrode consists of silver metal; b) contacting both the first and second electrodes with the sample comprising chloride ions; c) applying a first voltage between the first electrode as a cathode and the second electrode as an anode with a voltage sufficient for forming a layer of silver chloride at the surface of the second electrode; d) applying a second voltage between the first electrode as the anode and the second electrode as the cathode; and e) determining an electrical signal between the first and the second electrodes, whereby the analyte in the sample comprising the chloride ions is detected.. . ... Roche Diagnostics Operations Inc

04/12/18 / #20180099812

Sample container handling device

A sample container handling device is presented. The device comprises a linear transport unit and a release unit comprising a release blade segment. ... Roche Diagnostics Operations Inc

04/05/18 / #20180095036

Quality control material, system and method

A quality control (qc) material for performing a qc procedure with respect to at least one detector is introduced. The qc material comprises at least one first qc substance and at least one second qc substance, wherein the first qc substance is interferable with the second qc substance or with the performance and/or lifetime of the detector and wherein the first qc substance is entrapped by carrier particles that prevent the first qc substance to interfere with the second qc substance or with the performance and/or lifetime of the detector. ... Roche Diagnostics Operations Inc

04/05/18 / #20180093267

Rotatable cartridge with a metering chamber for analyzing a biological sample

An automatic analyzer cartridge, spinnable around a rotational axis, has aliquoting and metering chambers, a connecting duct there between, and a vent connected to the metering chamber and nearer to the rotational axis than the metering chamber. The metering chamber has side walls that taper away from a central region. ... Roche Diagnostics Operations Inc

03/22/18 / #20180080949

Automated scheduler for laboratory equipment

A method is presented. The method includes receiving at least one order, generating one or more optimization problem instances using one or more resource descriptions of automated laboratory equipment, one or more protocol descriptions of the automated laboratory equipment, an objective function and the at least one order. ... Roche Diagnostics Operations Inc

03/15/18 / #20180075223

Point of care testing (poct) system

Disclosed are a system architecture and a method to enable workflow solutions via remote configuration services for the configuration management of point of care analyzers. According to particular embodiments, the disclosed system and method are configured to enable remote configuration services of point of care analyzers across different platforms.. ... Roche Diagnostics Operations Inc

03/15/18 / #20180074087

Laboratory sample distribution system, laboratory system and method of operating

A laboratory sample distribution system is presented. The laboratory sample distribution system comprises a plurality of container carriers. ... Roche Diagnostics Operations Inc

03/15/18 / #20180071740

Cartridge for dispensing particles and a reagent fluid

A method of dispensing a particle mixture and a reagent fluid cartridge are presented. The cartridge comprises a first reservoir partially filled with reagent fluid, a second reservoir partially filled with particles, a pumping chamber, a first pumping chamber conduit connecting the first reservoir and the pumping chamber, a second pumping chamber conduit connecting the second reservoir and the pumping chamber, an outlet for dispensing reagent fluid and particles from the cartridge, an outlet conduit connecting the outlet to the pumping chamber, and a valve sealing the outlet conduit. ... Roche Diagnostics Operations Inc

03/08/18 / #20180067141

Method of operating a laboratory sample distribution system, laboratory sample distribution system and laboratory automation system

A method of operating a laboratory sample distribution system is presented. The laboratory sample distribution system comprises a number of sample container carriers. ... Roche Diagnostics Operations Inc

03/08/18 / #20180067140

Signal offset determination and correction

A method for determining a background shift is presented. The method includes obtaining a plurality of optical measurement sets of a sample taken by a sample analyzer at different points in time. ... Roche Diagnostics Operations Inc

03/08/18 / #20180067139

System and method for storing and retrieving vessel holders

An automated system and method for storing/retrieving vessel holders is presented. A first storage compartment comprises first storage sections. ... Roche Diagnostics Operations Inc

03/01/18 / #20180062857

Method for authenticating an instrument for processing a biological sample or reagent and system comprising an instrument for processing a biological sample or reagent

A method for authenticating an instrument for processing a biological sample or reagent is disclosed. The method comprises generating a pin code by the instrument, entering the pin code and identification data associated with the instrument in a database of an electronic device, verifying the pin code and identification data at the electronic device, transmitting an authentication certificate to the instrument if the pin code and identification data correspond to target data stored in the database, installing the authentication certificate on the instrument, whereby the instrument is registered with the electronic device, and using the authentication certificate for an encrypted communication between the instrument and the electronic device. ... Roche Diagnostics Operations Inc

03/01/18 / #20180056301

Test tube carrier

A test tube carrier for transporting test tubes in a laboratory automation system is presented. The test tube carrier comprises a base body and at least three centering fingers attached to the base body. ... Roche Diagnostics Operations Inc

02/01/18 / #20180029731

Recapper, laboratory automation system, and method of recapping a sample container

A recapper for placing foils on laboratory sample containers is presented. The foils are brought on the sample container by a lever arrangement that is rotated around a vertical axis.. ... Roche Diagnostics Operations Inc

01/11/18 / #20180010990

Automated system for processing particles

A method for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. ... Roche Diagnostics Operations Inc

01/04/18 / #20180003710

Method of assessing rheumatoid arthritis by measuring anti-ccp and anti-pik3cd

The present invention relates to a method aiding in the assessment of rheumatoid arthritis (“ra”). The method is used in assessing ra in vitro. ... Roche Diagnostics Operations Inc

12/21/17 / #20170363649

Release reagent for vitamin d compounds

A reagent composition for releasing vitamin d compounds bound to vitamin d-binding protein and an in vitro method for the detection of a vitamin d compound in which the vitamin d compound is released from vitamin d-binding protein by the use of this reagent composition as well as the reagent mixture obtained in this manner. Also disclosed is the use of the reagent compositions to release vitamin d compounds as well as a kit for detecting a vitamin d compound.. ... Roche Diagnostics Operations Inc

12/21/17 / #20170363624

Method of immobilizing a cell on a support using compounds comprising a polyethylene glycol moiety

The present invention relates to a method of immobilizing a cell on a support, the method comprising a) providing a compound or salt thereof comprising, preferably consisting of, one or more hydrophobic domains attached to a hydrophilic domain, wherein the one or more hydrophobic domains are covalently bound to said hydrophilic domain, and wherein the one or more hydrophobic domains each comprise a linear lipid, a steroid or a hydrophobic vitamin, and wherein the hydrophilic domain comprises a polyethylene glycol (peg) moiety, and wherein the compound comprises a linking group; b) contacting a cell with the compound under conditions allowing the interaction of the compound with the membrane of the cell, thereby immobilizing the linking group on the surface of the cell; and c) contacting the linking group immobilized on the cell with a support capable of binding the linking group, thereby immobilizing the cell on the support.. . ... Roche Diagnostics Operations Inc

12/21/17 / #20170363608

Method of setting a handover position and laboratory automation system

A method of setting a handover position of a gripping device at a laboratory automation system is presented. A position of a position determining device held by the gripping device is detected using position sensors in order to determine the handover position. ... Roche Diagnostics Operations Inc

12/07/17 / #20170350912

Supplying consumable items to an automated sample analyzer

A method for supplying consumable items to an automated sample analyzer is presented. The automated analyzer comprises a consumable repository including two or more storage areas. ... Roche Diagnostics Operations Inc

10/26/17 / #20170307643

Loading device for loading a reagent rotor of an analytical instrument with reagent vessels and analytical instrument

A loading device for loading a reagent rotor of an analytical instrument with reagent vessels is disclosed. The loading device comprises a tray to receive reagent vessels. ... Roche Diagnostics Operations Inc

10/12/17 / #20170292148

Detection of bacterial (mollicutes) contamination

The present disclosure provides a method and system for the pcr amplification of a target sequence which suppresses non-specific amplification products. The disclosure concerns the use of a primer pair optimized to amplify a nucleic acid of a contaminant in the background of genomic dna of a first organism. ... Roche Diagnostics Operations Inc

09/28/17 / #20170275381

Detection of a posttranslationally modified polypeptide by a bivalent binding agent

A bivalent binding agent having a first monovalent binder that binds to a polypeptide epitope of a target polypeptide, a second monovalent binder that binds to a posttranslational polypeptide modification on the target polypeptide and a linker. Further disclosed are methods for the detection of a posttranslationally modified target polypeptide, for making the disclosed bivalent binding agent, and for use of the disclosed bivalent binding agent in histological staining procedures.. ... Roche Diagnostics Operations Inc

09/28/17 / #20170275380

Detection of a polypeptide dimer by a bivalent binding agent

A bivalent binding agent, capable of binding a polypeptide dimer, consisting of two monovalent binders linked to each other via a linker, the first monovalent binder binds an epitope of a first target polypeptide comprised in said dimer and the second monovalent binder binds to an epitope of a second target polypeptide comprised in said dimer. Each monovalent binder has a kdiss in the range of 5×10−3/sec to 10−4/sec, and the bivalent binding agent has a kdiss of 3×10−5/sec or less. ... Roche Diagnostics Operations Inc

09/21/17 / #20170269068

Method for measurement of vitamin d

The present invention concerns an in vitro method for measurement of 25-hydroxyvitamin d, wherein the potentially interfering compound 24,25-dihydroxyvitamin d3 is blocked by a binding agent specifically binding to 24,25-dihydroxyvitamin d3 and not binding to 25-hydroxyvitamin d.. . ... Roche Diagnostics Operations Inc

09/14/17 / #20170261526

Quality controls of analyzers for biological samples

A method for monitoring the performance of an analyzer for biological samples having an automated preparation device is presented. The method comprises receiving an instruction that a monitoring procedure shall be executed, after receipt of the instruction that a monitoring procedure shall be executed, obtaining, by the automated preparation device, at least two quality control ingredients from a repository including a plurality of quality control ingredients, and mixing, by the automated preparation device, the at least two quality control ingredients in a sample preparation receptacle to obtain a quality control which mimics the properties of a biological sample to be analyzed by the analyzer. ... Roche Diagnostics Operations Inc

09/14/17 / #20170261517

Nt-pro anp and sflt-1 for the differentiation between circulatory and ischemic events

The present disclosure relates to the field of laboratory diagnostics. The present disclosure provides means and methods for differentiating between an acute circulatory event and an ischemic event, as the cause underlying an acute medical event of a patient.. ... Roche Diagnostics Operations Inc

09/14/17 / #20170261498

Chaperone-chaperone fusion polypeptides for reduction of interference and stabilization of immunoassays

The invention concerns a fusion polypeptide comprising several molecules of folding helper polypeptides, comprising one multimerization domain, in particular skp, and at least one molecule of slyd or slpa, wherein no further target polypeptide sequences are fused to said fusion polypeptide. The invention further concerns an immunoassay and the use of said fusion polypeptide in an immunoassay for reduction of interferences or minimizing false positive results or for stabilizing proteinaceous assay reagents. ... Roche Diagnostics Operations Inc

09/14/17 / #20170261490

Test element analysis system for the analytical examination of a sample

A test element analysis system for the analytical examination of a sample comprising: at least one evaluation device with at least one test element holder and at least one measuring device for measuring a change in a measuring zone of a test element; at least one barcode reader comprising at least one circuit board having a front side facing the barcode of the test element positioned in the test element holder and a reverse side facing away from the test element, wherein at least one electronic control element of the barcode reader is disposed on the circuit board and wherein the circuit board comprises at least one cavity penetrating the circuit board; at least one camera carrier element; and at least one camera electrically connected to the camera carrier element, with the camera carrier element and the camera being positioned such that the camera observes the barcode through the cavity.. . ... Roche Diagnostics Operations Inc

09/07/17 / #20170254825

Storage and supply for vessel holders

An automated system and method for processing vessels containing biological samples are presented. The system comprises vessel holders, a transport medium for transporting the vessel holders between the components of the system, a work cell for processing, a storage module for empty vessel holders, wherein the storage module is connected to the transport medium, a robotic manipulator for engaging and/or disengaging the vessels with empty vessel holders, an empty vessel holder transfer unit for introducing empty vessel holders into or retrieving them from the storage module, and an empty vessel holder detection unit, including an empty vessel holder detector for discriminating between filled and empty vessel holders as well as a transfer initiator configured to initiate the introduction or re-introduction of an empty vessel holder detected in or on the transport medium into the storage module by the empty vessel holder transfer unit.. ... Roche Diagnostics Operations Inc

09/07/17 / #20170254824

Sample carrier handling device

A sample carrier handling devices for manipulating a sample carrier is presented. The sample carrier is configured to carry a sample container containing a sample which is used in a diagnostics laboratory. ... Roche Diagnostics Operations Inc

09/07/17 / #20170254772

Test element for electrochemically detecting at least one analyte

A test element for electrochemically detecting at least one analyte in a bodily fluid is disclosed. The test element comprises at least one first electrode and at least one second electrode. ... Roche Diagnostics Operations Inc

09/07/17 / #20170253431

Transporting device for transporting a laboratory diagnostic vessel carrier

A transporting device for transporting a laboratory diagnostic vessel carrier from a first line portion to a second line portion of a conveying line is disclosed. The first line portion is above the second line portion with respect to gravity. ... Roche Diagnostics Operations Inc

09/07/17 / #20170251922

System for in-vivo measurement of an analyte concentration

The analyte concentration, such as glucose, in a human or animal body is measured with an implantable sensor that generates measurement signals. The measurement signals are compressed through statistical techniques to produced compressed measurement data that can is easier to process and communicate. ... Roche Diagnostics Operations Inc

08/31/17 / #20170248625

Device for mounting a plurality of actuator modules

A device for mounting a plurality of actuator modules in a grid pattern to a support frame with support bars is provided. Each actuator module has a regular polygonal basic shape with three, four or six corners. ... Roche Diagnostics Operations Inc

08/31/17 / #20170248624

Sample container carrier

A sample container carrier for transporting sample containers, for example test tubes and/or vials, in a laboratory automation system is presented. The sample container carrier comprises a body having a hollow center with a central axis (a). ... Roche Diagnostics Operations Inc

08/31/17 / #20170248623

Sample container carrier

A sample container carrier for transporting sample containers, for example test tubes and/or vials, in a laboratory automation system is presented. The sample container carrier comprises a body having a hollow center with a central axis. ... Roche Diagnostics Operations Inc

08/31/17 / #20170248598

Recombinant trypanosoma cruzi jl7 antigen variants and their use for detecting chagas disease

The invention concerns variants of jl7 antigens that are suitable for detecting antibodies against trypanosoma cruzi (causing chagas disease) in an isolated biological sample. These antigens comprise a jl7 specific amino acid sequence, said jl7 specific sequence consisting of two copies of seq id no. ... Roche Diagnostics Operations Inc

08/31/17 / #20170248597

Antigen composition for detecting chagas disease

The present invention concerns a composition of polypeptides suitable for detecting antibodies against trypanosoma cruzi (t. Cruzi) in an isolated biological sample consisting of three polypeptides 1f8, jl7 and cruzipain. ... Roche Diagnostics Operations Inc

08/31/17 / #20170247679

Blends containing proteases

Described are compositions, in particular lyophilizates, containing proteolytic enzymes, and methods for producing the compositions. Typically these compositions contain one or more proteases with collagenase activity and a neutral protease, for example, thermolysin. ... Roche Diagnostics Operations Inc

08/24/17 / #20170240945

Interference compensating two electrodes test strip

A method of detecting at least one analyte in a test sample is provided comprising a) contacting the test sample (i) to an active chemistry matrix changing at least one electrochemical property dependent on an enzymatic activity active in the presence of the analyte, the active chemistry matrix contacting a first electrode; and (ii) to an inactive chemistry matrix, the inactive chemistry matrix contacting a second electrode, b) closing an electrical circuit including the first electrode, the second electrode, and the active chemistry matrix and inactive chemistry matrix, followed by determining a first value of the at least one electrochemical property, c) inverting electrical polarity of the electrical circuit of b), followed by determining a second value of the at least one electrochemical property, and d) detecting the at least one analyte based on the first value and on the second value.. . ... Roche Diagnostics Operations Inc

08/10/17 / #20170227552

Biomarkers for risk prediction of mortality

The present invention relates to a method for predicting the risk of a subject of rapidly progressing to chronic heart failure and/or of hospitalization due to chronic heart failure and/or death. The method is based on the determination of at least one biomarker selected from the group consisting of a bnp-type peptide, igfbp7 (igf binding protein 7), a cardiac troponin, soluble st2 (sst2), fgf-23 (fibroblast growth factor 23), and growth differentiation factor 15 (gdf-15), in a sample of a subject. ... Roche Diagnostics Operations Inc

08/10/17 / #20170226068

Phenazinium mediators

The present invention relates to a chemical compound or a salt or solvate thereof being an 1-amino-phenazine derivative and to uses thereof. The present invention further relates to a chemistry matrix and to a test element comprising the aforesaid chemical compound. ... Roche Diagnostics Operations Inc

07/27/17 / #20170212141

Method and device for transferring sample tubes between a laboratory automation system and a sample archiving system

A method and a device for transferring tubes between a laboratory automation system and a sample archiving system are presented. When transferring a tube from the laboratory automation system to the sample archiving system, a tube carrier carrying a tube is conveyed to a first take-over module via a first conveyor. ... Roche Diagnostics Operations Inc

07/27/17 / #20170212140

Laboratory sample container carrier handling apparatus and laboratory system

A sample container carrier handling apparatus is presented. A first revolving device located at a first level moves sample container carriers along a first path. ... Roche Diagnostics Operations Inc

07/27/17 / #20170212139

Device for lifting a sample tube

A device for lifting a sample tube comprising a holder having holding elements for holding a sample tube is presented. The holder is supported moveably in the vertical direction between a lower holder position and an upper holder position for lifting and lowering a held sample tube. ... Roche Diagnostics Operations Inc

07/06/17 / #20170191990

Redoxindicators

The present invention relates to a chemical compound or a salt or solvate thereof being a phenazine-, phenanthridine-, phenanthroline-, quinoline-, quinoxaline-, acridine- isoquinoline-, pyrazine- or pyridine-derivative comprising a conjugated π-system and a π-acceptor group, and to uses thereof. The present invention further relates to a chemistry matrix and to a test element comprising the chemical compound of the present invention. ... Roche Diagnostics Operations Inc

06/29/17 / #20170184622

Method of operating a laboratory sample distribution system, laboratory sample distribution system and laboratory automation system

A method of operating a laboratory sample distribution system is presented. The method comprises a number of sample container carriers on a transport plane by a number of electro-magnetic actuators. ... Roche Diagnostics Operations Inc

06/29/17 / #20170184591

Soluble and immunoreactive variants of htlv capsid antigen p24

The invention concerns soluble and antigenic htlv p24 variants that can be fused to chaperones and their use in diagnostic applications such as immunoassays for detecting antibodies against htlv-i or htlv-ii in an isolated biological sample. In particular, the invention relates to a soluble htlv-i or htlv-ii p24 antigen comprising either the n- or the c-terminal domain of p24 and lacking the other domain. ... Roche Diagnostics Operations Inc

06/22/17 / #20170177913

Method for storing temporary data in a memory of an rfid tag associated with a consumable of a laboratory instrument and system comprising a laboratory instrument, consumable and rfid tag

A method for storing temporary data in a memory of a rfid tag associated with a consumable of a laboratory instrument for processing a reagent or biological sample is disclosed. The method comprises providing the rfid tag associated with the consumable. ... Roche Diagnostics Operations Inc

06/22/17 / #20170177880

Method of restoring settings of an instrument for processing a sample or a reagent and a system for processing a sample or reagent

A method for saving and/or restoring settings of an instrument for processing a sample or reagent is disclosed. The instrument comprises a control unit and an operating system. ... Roche Diagnostics Operations Inc

06/22/17 / #20170176478

Calibration and/or error detection in an optical measurement device for biological samples

A method for calibration and/or error detection in an optical measurement device for biological samples having at least a first and a second measurement channel is described. The method comprises calculating an updated reference factor for the second measurement channel based on the first and second detection signals, comparing the updated reference factor with at least one current reference factors and depending on the result of the comparison, storing the updated reference factor as a current reference factor for use in a later measurement in the second measurement channel or keeping the current reference factors for use in a later measurement in the second measurement channel.. ... Roche Diagnostics Operations Inc

06/22/17 / #20170176306

Blood collector with capillary structure

System and method of determining an amount of an analyte in a blood sample using a cartridge and blood collector are disclosed. The blood collector has a mounting surface, a capillary structure with a curved portion, and a capillary inlet. ... Roche Diagnostics Operations Inc

06/22/17 / #20170174448

Laboratory sample distribution system and laboratory automation system

A laboratory sample distribution system in which a sample container carrier can be centered at a specific position is presented. A laboratory automation system with such a laboratory sample distribution system is also presented.. ... Roche Diagnostics Operations Inc

06/15/17 / #20170168079

Set of sample container carriers for a laboratory sample distribution system, laboratory sample distribution system and laboratory automation system

A set of sample container carriers, a laboratory sample distribution system comprising such a set of sample container carriers, and a laboratory automation system comprising such a laboratory sample distribution system are presented. The set of sample container carriers comprises sample container carriers of a first type and a second type. ... Roche Diagnostics Operations Inc

06/08/17 / #20170160299

Laboratory sample distribution system and laboratory automation system

A laboratory sample distribution system and to a laboratory automation system comprising a printed circuit board arrangement and a coil are presented. The printed circuit board arrangement and the coil are configured such that assembly and maintenance of the laboratory automation system are greatly simplified.. ... Roche Diagnostics Operations Inc

05/18/17 / #20170142324

Method for generating an entry for an electronic laboratory journal

A method for generating an entry for an electronic laboratory journal is presented. The method includes selecting a laboratory workflow specifying at least one action an operator has to carry out. ... Roche Diagnostics Operations Inc

05/18/17 / #20170138971

Laboratory sample distribution system and corresponding method of operation

A laboratory sample distribution system is presented. The laboratory sample distribution system comprises a number of container carriers. ... Roche Diagnostics Operations Inc

05/11/17 / #20170131310

Sample container carrier, laboratory sample distribution system and laboratory automation system

A sample container carrier for a laboratory sample distribution system having a cover above a magnet in order to suitably align magnetic field lines is presented. A laboratory sample distribution system having such a sample container carrier and to a laboratory automation system containing such a laboratory sample distribution system are also presented.. ... Roche Diagnostics Operations Inc

05/11/17 / #20170131309

Laboratory sample distribution system and laboratory automation system

A laboratory sample distribution system is presented. The system comprises sample container carriers carrying a sample container and comprising a magnetically active device. ... Roche Diagnostics Operations Inc

05/11/17 / #20170131307

Laboratory sample distribution system and laboratory automation system

A laboratory sample distribution system and a laboratory automation system comprising such a laboratory sample distribution system are presented. The laboratory sample distribution system comprises a number of sample container carriers adapted to move autonomously and to communicate with each other and with a central control unit.. ... Roche Diagnostics Operations Inc

04/27/17 / #20170115294

Use of protein s100a12 as a marker for colorectal cancer

The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein s100a12 in the diagnosis of colorectal cancer. ... Roche Diagnostics Operations Inc

04/20/17 / #20170108522

Method of rotating a sample container carrier, laboratory sample distribution system and laboratory automation system

A method of rotating a sample container carrier on a transport plane of a laboratory sample distribution system is presented. The sample container carrier is rotated by using a movement relative to a number of rotator elements. ... Roche Diagnostics Operations Inc

04/13/17 / #20170101277

Laboratory sample distribution system and laboratory automation system

A laboratory sample distribution system and a laboratory automation system comprising such a laboratory sample distribution system are presented. The laboratory sample distribution system comprises a plurality of electro-magnetic actuators. ... Roche Diagnostics Operations Inc

04/13/17 / #20170101272

Laboratory distribution system for conveying test tube holders

A conveyor device for conveying test tube holders in a laboratory distribution system is presented. The conveyor device is a screw conveyor device comprising a helical track having a helix axis and a drive shaft having an axis of rotation parallel or coaxial to the helix axis, which drive shaft is adapted to be driven to rotate about the axis of rotation for causing a movement of one test tube holder or a plurality of test tube holders contacting the helical track between an entry region and an exit region. ... Roche Diagnostics Operations Inc

04/06/17 / #20170097372

Laboratory sample distribution system, laboratory system and method of operating

A laboratory sample distribution system is presented. The laboratory sample distribution system comprises a plurality of container carriers. ... Roche Diagnostics Operations Inc

04/06/17 / #20170097370

Apparatus and method for processing at least one sample

A method and apparatus for processing a sample is presented. The apparatus comprises a chamber, a first input for inputting a first vessel into the chamber, a second input for inputting a second vessel into the chamber, the second input is different from the first input, a rotor comprising a first compartment for receiving the first vessel and a second compartment for receiving the second vessel, a gripper to grip the first vessel and to transport the first vessel to the first compartment, and a pipettor to pipette a sample from the first vessel and/or second vessel. ... Roche Diagnostics Operations Inc

04/06/17 / #20170096307

Method of configuring a laboratory automation system, laboratory sample distribution system and laboratory automation system

A method of configuring a laboratory automation system is presented. The position of a laboratory station is detected automatically. ... Roche Diagnostics Operations Inc

04/06/17 / #20170095814

Cartridge with a rotatable lid

An automatic analyzer cartridge, spinnable around a rotational axis, has a support structure with a front face perpendicular to the rotational axis, a fluidic structure for processing a biological sample into the processed biological sample, a measurement structure with at least one detection zone on the front face, and a rotatable lid covering the front face. The rotatable lid is rotatable about the rotational axis relative to the support structure from a first position relative to the support structure to a second position relative to the support structure. ... Roche Diagnostics Operations Inc

04/06/17 / #20170095813

Rotatable cartridge for analyzing a biological sample

An automatic analyzer cartridge spinnable around a rotational axis has a fluid chamber for receiving a fluid, an aliquoting chamber, a duct connecting the fluid chamber and the aliquoting chamber, a downstream fluidic element, a siphon for siphoning the fluid from the aliquoting chamber to the downstream fluidic element, a fluidic structure for processing a biological sample into the processed biological sample, and a measurement structure for enabling measurement of the processed biological sample. The siphon has a siphon entrance in the aliquoting chamber and a siphon exit in the downstream fluidic element, wherein the siphon has a bend, wherein the bend is the portion of the siphon closest to the rotational axis, wherein the siphon entrance starts at the bend, wherein the siphon entrance extends to a lower portion of the aliquoting chamber. ... Roche Diagnostics Operations Inc

04/06/17 / #20170095812

Rotatable cartridge with a metering chamber for analyzing a biological sample

An automatic analyzer cartridge, spinnable around a rotational axis, has aliquoting and metering chambers, a connecting duct there between, and a vent connected to the metering chamber and nearer to the rotational axis than the metering chamber. The metering chamber has side walls that taper away from a central region. ... Roche Diagnostics Operations Inc

04/06/17 / #20170095811

Rotatable cartridge for processing and analyzing a biological sample

An automatic analyzer cartridge, spinnable about a rotational axis, has fluid and aliquoting chambers, a metering chamber connected to a vent that is nearer to the rotational axis than the metering chamber, first and second ducts connecting the fluid and aliquoting chambers, and the metering and aliquoting chambers, respectively. Metering chamber side walls taper away from a central region, wherein capillary action next to the walls is greater than in the central region. ... Roche Diagnostics Operations Inc

03/30/17 / #20170089631

Condensed water collector

A compartment comprising at least one target area susceptible to condensed water formation includes at least one condensed water collector is presented. The condensed water collector comprises at least a first portion arranged to collect condensed water from the at least one target area and at least a second portion outside of the at least one target area. ... Roche Diagnostics Operations Inc

03/23/17 / #20170082639

Prediction and recognition of acute kidney injury after surgery

Systems, kits, and methods for predicting the risk of an adverse event related to acute kidney injury aki as a consequence of a surgical intervention in a subject. Embodiments of the system and methods include means and steps for determining an amount of liver-type fatty acid binding protein (l-fabp) in a sample, such as a urine-sample of a subject; comparing the amounts of the l-fabp with a reference amount, and predicting the risk of an adverse event related to acute kidney injury as a consequence of surgical intervention in the subject.. ... Roche Diagnostics Operations Inc

03/16/17 / #20170074892

Tnt based diagnosis of paroxysmal atrial fibrillation

The present invention relates to a method for diagnosing a recent paroxysmal atrial fibrillation. The method is based on the determination of the at least one marker selected from the group consisting of a cardiac troponin, nt-probnp (n-terminal prohormone of brain natriuretic peptide), hscrp, il-6 (interleukin-6) and igfbp7 (insulin like growth factor binding protein 7) in a sample from the subject, and on the comparison of the, thus, determined amount(s) with a reference amount (reference amounts). ... Roche Diagnostics Operations Inc

03/09/17 / #20170067926

Laboratory analyzer for manually handling a plurality of reagents and method for operating a laboratory analyzer for manually handling a plurality of reagents

A laboratory analyzer for manually handling a plurality of reagents is disclosed. The laboratory analyzer comprises a computing device comprising a display for displaying a workflow of a pipetting process comprising a plurality of method steps to an operator, a pipette for pipetting reagents connected to the computing device, a plurality of compartments for receiving a plurality of reagents vessels including reagents to be pipetted by the pipette, and a camera connected to the computing device. ... Roche Diagnostics Operations Inc

03/09/17 / #20170067922

Analytical test management system and method

A test management system is presented. The system comprises an analyzer to perform tests a sample according to a first set of instructions, a manager module connected to the analyzer, and a first order interface connected to the manager module. ... Roche Diagnostics Operations Inc

03/02/17 / #20170059599

Laboratory cargo distribution system, laboratory automation system and method of operating a laboratory cargo distribution system

A laboratory cargo distribution system is presented. The laboratory cargo distribution system comprises a number of transport carriers, a transport plane, a number of electro-magnetic actuators, a storage device and a control device. ... Roche Diagnostics Operations Inc

03/02/17 / #20170059597

Movable loading element for loading an automated analysis system

A device for loading an automated analysis system is presented. The device comprises a chassis, a movable loading element movably coupled to the chassis and configured to move between a first and a second position, a holding structure, the holding structure being floatingly coupled to the movable loading element, the holding structure being configured to hold a receptacle for material to be loaded into the automated analysis system, a first alignment element attached to the chassis and a second alignment element attached to the holding structure. ... Roche Diagnostics Operations Inc

03/02/17 / #20170059564

Immunological test element with improved control zone

The invention concerns a test element for carrying out an immunological sandwich test for determining an analyte from a liquid sample containing a reagent zone or conjugate zone which contains a conjugate of an analyte binding partner and a label which can be detected directly or indirectly by visual, optical or electrochemical means (e.g. An enzyme, fluorescent or direct label etc.) wherein said conjugate can be dissolved by the liquid sample, a detection zone which contains a permanently immobilized (i.e. ... Roche Diagnostics Operations Inc

02/09/17 / #20170037390

Recombinantly produced neutral protease originating from paenibacillus polymyxa

The present disclosure provides the sequence of a paenibacillus polymyxa preproenzyme which is the precursor of a neutral protease, expression thereof in a transformed host organism, and methods for production of the neutral protease, by recombinant means. Further, use of the recombinantly produced neutral protease is disclosed in the field of cell biology, particularly for the purpose of tissue dissociation. ... Roche Diagnostics Operations Inc

02/09/17 / #20170036206

Handling of sample tubes comprising geometric tube data

A method for handling a sample tube containing a biological sample is presented. A tube label can be attached to the sample tube. ... Roche Diagnostics Operations Inc

01/26/17 / #20170023588

Troponin and bnp based diagnosis of risk patients and cause of stroke

Method for determination of whether a subject suffers from intermittent atrial fibrillation based on the determination of the amount of a troponin t in a sample in a patient suffering from atrial fibrillation using a binding assay. Kits and devices adapted to carry out the methods are also provided.. ... Roche Diagnostics Operations Inc

01/12/17 / #20170010283

Igfbp7 for diagnosing diastolic dysfunction

The present invention relates to a method for diagnosing and/or grading diastolic dysfunction or at least one structural or functional abnormality associated with diastolic dysfunction. The method comprises measuring the level of igfbp7 (insulin like growth factor binding protein 7) and, optionally, the level of at least one further marker in a patient suffering from heart failure, and comparing the level to a reference level. ... Roche Diagnostics Operations Inc

01/05/17 / #20170004394

Orientation identification label, reagent container carrier structure, analyzer device and reader module

A reagent container carrier structure for holding at least one reagent container, wherein the carrier structure has thereon an rfid assembly and an optically detectable definition pattern defining an orientation of the carrier structure, is disclosed. The reagent container carrier structure may have an orientation identification label that has a front surface and a back surface, and further include an rfid assembly positioned on the back surface, and an optically detectable definition pattern defining an orientation of the label on the front surface. ... Roche Diagnostics Operations Inc








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