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Roche Diagnostics Operations Inc patents (2015 archive)


Recent patent applications related to Roche Diagnostics Operations Inc. Roche Diagnostics Operations Inc is listed as an Agent/Assignee. Note: Roche Diagnostics Operations Inc may have other listings under different names/spellings. We're not affiliated with Roche Diagnostics Operations Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "R" | Roche Diagnostics Operations Inc-related inventors


12/17/15 / #20150362516

In-vitro diagnostic analysis method and system

A method and system for automatic in-vitro diagnostic analysis are described. The method comprises adding a first reagent type and a second reagent type to a first test liquid during a first and second cycle times respectively. ... Roche Diagnostics Operations Inc

12/17/15 / #20150360878

Laboratory sample distribution system and corresponding method of operation

A laboratory sample distribution system is presented. The system comprises a plurality of container carriers. ... Roche Diagnostics Operations Inc

12/17/15 / #20150360876

Laboratory sample distribution system and laboratory automation system

A laboratory sample distribution system comprising a number of sample container carriers moving on a transport plane is presented. The system further comprises an earthquake detection device in order to minimize influences on operation of the system by an earthquake. ... Roche Diagnostics Operations Inc

12/10/15 / #20150355206

Handling of sample tubes comprising geometric tube data

A method for handling a sample tube containing a biological sample is presented. A tube label can be attached to the sample tube. ... Roche Diagnostics Operations Inc

12/10/15 / #20150355199

Agents, kits and methods for complement factor h-related protein 1 detection

The present invention relates to an assay for specific detection of complement factor h-related protein 1 (cfhr1) in a sample from a subject, as well as kits and agents related thereto.. . ... Roche Diagnostics Operations Inc

12/03/15 / #20150347698

Hazard based assessment patterns

Methods and devices for retrospectively assessing continuous monitoring reference pattern data to determine a risk of a patient glucose level measurement taken in at least one data segment being outside a predetermined range. The methods and devices can include executing an algorithm to compare risk scores derived from reference pattern data in a currently collected data segment with risk scores of previously stored reference pattern data of previously collected data segments for a patient for assessing risk.. ... Roche Diagnostics Operations Inc

12/03/15 / #20150346229

Method for operating an automated sample workcell

A method of operating the automated sample workcell for processing one or more biological samples is presented. The method comprises receiving one or more biological samples. ... Roche Diagnostics Operations Inc

11/26/15 / #20150339438

Analysis system and computer implemented method for analyzing biological samples

Analysis system and computer implemented method for analyzing biological samples are disclosed. The system has at least one analyzer for performing an analysis and a decision unit being operable to determine in response to the receipt of the analysis request whether results obtained from performing the analysis on the sample indicated in the analysis request are valid. ... Roche Diagnostics Operations Inc

11/26/15 / #20150338415

Means amd methods applying sflt-1/pigf or endoglin/pigf ratio to rule out onset of preeclampsia within a certain time period

The present invention concerns the field of diagnostic assays for prenatal diagnosis of preeclampsia. In particular, it relates to a method for diagnosing whether a pregnant subject is not at risk for preeclampsia within a short window of time comprising a) determining the amount of at least one angiogenesis biomarker selected from the group consisting of sflt-1, endoglin and plgf in a sample of said subject, and b) comparing the amount with a reference, whereby a subject being not at risk for developing preeclampsia within a short period of time is diagnosed if the amount is identical or decreased compared to the reference in the cases of sflt-1 and endoglin and identical or increased in the case of plgf, wherein said reference allows for making the diagnosis with a negative predictive value of at least about 98%. ... Roche Diagnostics Operations Inc

11/26/15 / #20150338349

Bg meter illuminated test strip

A handheld medical device is configured to illuminate a test strip inserted therein and may include a housing having a port configured to receive a test strip. A circuit board may be mounted inside the housing. ... Roche Diagnostics Operations Inc

11/26/15 / #20150338288

Handheld analyte meter with recharging control for improved analyte testing

A handheld analyte meter, such as a blood glucose meter, has a measurement module, a rechargeable battery and a charging control to select a maximum charging current to regulate self-heating during recharging that can interfere with analyte tests. Self-heating by the meter can bias temperature measurements made inside the meter that are used to determine whether the temperature is acceptable for testing. ... Roche Diagnostics Operations Inc

11/26/15 / #20150337282

Stabilization of thermolysin in aqueous solution

The present invention deals with the proteolytic enzyme thermolysin which tends to be unstable in aqueous solution. The invention provides methods and compositions to enhance the stability of dissolved thermolysin in aqueous solution. ... Roche Diagnostics Operations Inc

11/12/15 / #20150324520

Blood glucose meter supporting contextual data filtering

The handheld blood glucose meter creates blood glucose records having contextual information to improve filtering of blood glucose records for improved healthcare decisions. The contextual information includes events and associated sub-events. ... Roche Diagnostics Operations Inc

11/12/15 / #20150320345

Eletrochemical sensor having symmetrically distributed analyte sensitive areas

The present invention provides an electrochemical sensor that employs multiple electrode areas that are exposed for contact with a body fluid, e.g., when the sensor is inserted subcutaneously into a patient's skin. The exposed electrode areas are arranged symmetrically, such that a symmetrical potential distribution is produced when an ac signal is applied to the sensor. ... Roche Diagnostics Operations Inc

10/22/15 / #20150300974

Systems and methods for multiple analyte analysis

Systems and methods for multiple analyte analysis are provided. In one embodiment, a method includes determining concentrations of first and second analytes in a sample. ... Roche Diagnostics Operations Inc

10/01/15 / #20150276782

Sample distribution system and laboratory automation system

A sample distribution system having a transport surface on which sample container carriers can be moved is presented. The sample distribution system has ambient-condition influencing device in order to influence ambient conditions over a sub-region of the transport surface in such a way that samples can be kept there for a certain time without impairment.. ... Roche Diagnostics Operations Inc

10/01/15 / #20150276781

Sample distribution system and laboratory automation system

A sample distribution system having a transport surface and sample container carriers arranged thereupon is disclosed. A dirt detection device for limiting the effect of dirt is provided.. ... Roche Diagnostics Operations Inc

10/01/15 / #20150276778

Vertical conveying device, laboratory sample distribution system and laboratory automation system

A vertical conveying device for the transport of sample container carriers having sample tubes received therein between a bottom level and a top level of a sample distribution system is presented. The vertical conveying device comprises a plurality of conveying surfaces which are movable along a circulating path. ... Roche Diagnostics Operations Inc

10/01/15 / #20150276777

Transport device, sample distribution system and laboratory automation system

A transport device for receiving a sample container and for transporting the sample container on a transport surface, the transport device being capable of being moved magnetically over the transport surface and, further, having a cooling device is presented. A sample distribution system comprising such a transport device and to a laboratory automation system is also presented.. ... Roche Diagnostics Operations Inc

10/01/15 / #20150276776

Dispatching device, sample distribution system and laboratory automation system

A dispatching device for dispatching sample containers received in respective sample container carriers from a transport surface to an external position and/or from the external position to the transport surface is presented. The dispatching device has a tube and a capsule, a conveying surface with an electromagnetic actuator being formed in the capsule. ... Roche Diagnostics Operations Inc

10/01/15 / #20150273147

System and method for adjusting therapy based on risk associated with a glucose state

The present disclosure relates to a system and method for determining a basal rate adjustment based on risk associated with a glucose state of a person with diabetes. A method may include detecting a glucose state of the person based on a received glucose measurement signal and determining a current risk metric associated with the detected glucose state. ... Roche Diagnostics Operations Inc

09/24/15 / #20150268251

Biomarkers in the selection of therapy of heart failure

The present invention relates to a method for identifying a subject being eligible to the administration of at least one medicament selected from the group consisting of a beta blocker, an aldosterone antagonist, a diuretic, and an inhibitor of the renin-angiotensin system. The method is based on the determination of the amount of at least one biomarker selected from the group consisting of gdf-15 (growth differentiation factor 15), endostatin, mimecan, igfbp7 (igf binding protein 7), a cardiac troponin, a bnp-type peptide, uric acid, gal3 (galectin-3), osteopontin, sst2 (soluble st2), plgf, sflt-1, p1np, cystatin c, prealbumin, and transferrin in a sample from a subject suffering from heart failure. ... Roche Diagnostics Operations Inc

09/17/15 / #20150260744

System and method for locating sample vessels

A system and method for locating sample vessels are presented. The system comprises a holder having an array of positions for holding sample vessels. ... Roche Diagnostics Operations Inc

09/03/15 / #20150247867

Use of gfap for identification of intracerebral hemorrhage

The present invention relates to the use of glial fibrillary acidic protein (gfap) as a diagnostic marker for intracerebral hemorrhage. The invention especially relates to methods for the early detection of intracerebral hemorrhage. ... Roche Diagnostics Operations Inc

08/20/15 / #20150233957

Transport device, sample distribution system and laboratory automation system

A transport device for a sample container is presented. The transport device has a chuck for holding the sample container. ... Roche Diagnostics Operations Inc

08/20/15 / #20150233956

Transport device, sample distribution system, and laboratory automation system

A transport device for transporting a sample container along a transport surface is presented. The transport device comprises a permanent magnet, a holding unit and a receiving unit. ... Roche Diagnostics Operations Inc

08/20/15 / #20150233946

Tnt based diagnosis of paroxysmal atrial fibrillation

The present invention relates to a method for diagnosing a recent paroxysmal atrial fibrillation. The method is based on the determination of the at least one marker selected from the group consisting of a cardiac troponin, nt-probnp (n-terminal prohormone of brain natriuretic peptide), hscrp, il-6 (interleukin-6) and igfbp7 (insulin like growth factor binding protein 7) in a sample from the subject, and on the comparison of the, thus, determined amount(s) with a reference amount (reference amounts). ... Roche Diagnostics Operations Inc

08/20/15 / #20150233945

Ntprobnp and ctnt based therapy guidance in heart failure

The present invention relates to a method for guiding heart failure treatment in a subject suffering from heart failure. The method is based on the determination of the amount of a bnp-type peptide and a cardiac troponin in a sample from said subject. ... Roche Diagnostics Operations Inc

08/20/15 / #20150233889

Process and production device for the production of at least one analytical device

A process for the production of at least one analytical device is disclosed. The analytical device comprises at least one capillary element. ... Roche Diagnostics Operations Inc

08/13/15 / #20150226753

Release reagent for vitamin d compounds

A reagent composition for releasing vitamin d compounds bound to vitamin d-binding protein, an in vitro method for the detection of a vitamin d compound in which the vitamin d compound is released from vitamin d-binding protein by the use of this reagent composition and the reagent mixture obtained in this manner. The use of the disclosed reagent composition to release vitamin d compounds as well as a kit for detecting a vitamin d compound which contains the reagent composition for releasing vitamin d compounds in addition to common detecting reagents.. ... Roche Diagnostics Operations Inc

08/13/15 / #20150224500

Cartridge for dispensing a fluid comprising a reagent

A cartridge for dispensing a fluid is presented. The cartridge comprises a reservoir chamber for receiving the fluid and for receiving a ventilation gas. ... Roche Diagnostics Operations Inc

08/13/15 / #20150224497

Sample collection tubes

A sample collection tube is disclosed for collecting a body fluid sample. The tube includes a closure arranged at an open end to close the open end and a partially evacuated inner space. ... Roche Diagnostics Operations Inc

07/30/15 / #20150212104

Method for operating an automated sample workcell

A method of operating the automated sample workcell for processing one or more biological samples is presented. The method comprises receiving one or more biological samples. ... Roche Diagnostics Operations Inc

07/23/15 / #20150204863

Methods of specifically releasing a sub-group of objects

The present invention relates to a method of specifically releasing a one or more members of a sub-group of objects from an entity, a method of detecting a subject's disease by detecting one or more members of a sub-group of biological entities indicative of the disease and a method of isolating one or more members of a sub-group of objects from a group of objects.. . ... Roche Diagnostics Operations Inc

07/16/15 / #20150196258

Low energy wireless communication systems and methods for medical devices

A method performed by a medical device for transmitting data packets includes: removing select data fields from a data packet defined in accordance with ieee standard 11073 to form a modified data packet; determining a length of the modified data packet; determining whether the length of the modified data packet is greater than a predetermined maximum length of data packets under the bluetooth low energy protocol, as defined in bluetooth core specification version 4.0 or higher; when the length of the modified data packet is greater than the predetermined maximum length of data packets defined under the bluetooth low energy protocol, partitioning the modified data packet into a plurality of individual data packets, wherein each of the individual data packets includes a portion of the modified data packet; and transmitting the individual data packets via an antenna in accordance with the bluetooth low energy protocol.. . ... Roche Diagnostics Operations Inc

07/09/15 / #20150192587

Use of protein s100a12 as a marker for colorectal cancer

The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein s100a12 in the diagnosis of colorectal cancer. ... Roche Diagnostics Operations Inc

07/02/15 / #20150185230

Identification of patients with abnormal fractional shortening

The present invention relates to a method for assessing whether a subject shall be subjected to an imaging based diagnostic assessment. The method is based on the determination of the amount(s) of a cardiac troponin and/or fibroblast growth factor 23 (fgf-23) in a sample from the subject, and on the comparison of the, thus, determined amount(s) with a reference amount (reference amounts). ... Roche Diagnostics Operations Inc

06/25/15 / #20150178508

Controlling an analysis system of biological samples

A method for controlling an analysis system is presented. The method comprises receiving, by an encryption unit, authentication data of a user. ... Roche Diagnostics Operations Inc

06/25/15 / #20150177268

Storage and supply for vessel holders

An automated system and method for processing vessels containing biological samples are presented. The system comprises vessel holders, a transport medium for transporting the vessel holders between the components of the system, a work cell for processing, a storage module for empty vessel holders, wherein the storage module is connected to the transport medium, a robotic manipulator for engaging and/or disengaging the vessels with empty vessel holders, an empty vessel holder transfer unit for introducing empty vessel holders into or retrieving them from the storage module, and an empty vessel holder detection unit, including an empty vessel holder detector for discriminating between filled and empty vessel holders as well as a transfer initiator configured to initiate the introduction or re-introduction of an empty vessel holder detected in or on the transport medium into the storage module by the empty vessel holder transfer unit.. ... Roche Diagnostics Operations Inc

06/18/15 / #20150166973

Recombinantly produced neutral protease originating from paenibacillus polymyxa

The present disclosure provides the sequence of a paenibacillus polymyxa preproenzyme which is the precursor of a neutral protease, expression thereof in a transformed host organism, and methods for production of the neutral protease, by recombinant means. Further, use of the recombinantly produced neutral protease is disclosed in the field of cell biology, particularly for the purpose of tissue dissociation. ... Roche Diagnostics Operations Inc

06/11/15 / #20150160250

Device for gripping vessels

A device for gripping vessels is presented. The device comprises a mount, a support having a longitudinal axis coupled to the mount so to be rotatable relative to the mount around the longitudinal axis, a rotating mechanism for rotating the support, a gripper coupled to the support so to be translatable relative to the support along the longitudinal axis. ... Roche Diagnostics Operations Inc

06/11/15 / #20150160249

Tube rack transfer device and diagnostic instrument

A tube rack transfer device for transferring racks is presented. A first rail extends in a first horizontal direction and a second rail extends in a second horizontal direction orthogonal to the first direction. ... Roche Diagnostics Operations Inc

06/11/15 / #20150157788

Therapeutic system with an adaptor for an infusion set

A therapeutic system configured for the delivery of fluid. The therapeutic system in an exemplary embodiment comprises a fluid delivery device having a fluid reservoir, an outlet port with a lumen for outputting the fluid from the reservoir, a pump for pumping the fluid through the lumen and a controller for controlling the therapeutic system. ... Roche Diagnostics Operations Inc

06/04/15 / #20150153323

Plasma separation system and method for plasma separation

The disclosure relates to a system for separating plasma from whole blood, with a collector vessel for receiving whole blood, a filtering device for extracting plasma, whose input side can be attached to the collector vessel, and with a transport unit furnished with a pump for creating a partial vacuum. The transport unit is part of an analyser and the filtering device together with the attached collector vessel may be docked onto the sample input part of the analyser via the output side of the filtering device.. ... Roche Diagnostics Operations Inc

06/04/15 / #20150153258

Method and separation device for separating a filtrate from a sample fluid

A separation device for separating a filtrate from a sample fluid, especially for extracting plasma from whole blood, comprising a sample container for receiving the sample fluid and a filter plunger to be introduced under seal into the sample container, which filter plunger has a filter element at its front end and a grip element on the opposite end and will receive in its interior the filtrate obtained. After insertion of the filter plunger into the sample container an annular chamber is formed between the inner wall of the sample container and the outer wall of the filter plunger, which is sealed against the exterior by a sealing lip and in which an air cushion is formed upon introduction of the filter plunger into the sample container, which acts on the sample fluid. ... Roche Diagnostics Operations Inc

06/04/15 / #20150151082

Cradle including optical indication device

A cradle and methods of using embodiments of the cradle are described. The cradle has a proximal side and a distal side, where the proximal side has a skin attachment member for releasable attachment to a patient's skin. ... Roche Diagnostics Operations Inc

06/04/15 / #20150151041

Automatic device for transferring fluid

A transfer station for transferring a medical fluid between at least one supply container and at least one administration container of an infusion device is described. In an embodiment, the transfer station comprises at least one supply port configured for fluidic connection of the at least one supply container to the transfer station, and at least one exit port configured for fluidic connection of the at least one administration container to the transfer station. ... Roche Diagnostics Operations Inc

06/04/15 / #20150151035

Device and filter cartridge for separating plasma from whole blood

A multi-part device for separating plasma from whole blood is provided, with a sample taking unit for receiving whole blood, a filter unit with a layered filter with multiple layers for extracting plasma, and a pumping unit, typically a plunger pump, for creating a partial vacuum in the filter unit. The filter unit and a plasma collector vessel with a conical tip extending towards the filter unit are contained in a filter cartridge, which may be taken apart after plasma extraction, thus exposing the conical tip of the plasma collector vessel for sample input into an analyser.. ... Roche Diagnostics Operations Inc

06/04/15 / #20150150496

Reuse protection for lancet system

A lancet magazine for use in a lancing aid is described comprising a plurality of lancets each having a lancet body at the proximal end of the lancet and a lancet tip at the distal end of the lancet, where the proximal end of the lancet points in the direction of the proximal end of the housing of the lancet magazine and the distal end of the lancet is aligned in the direction of the distal end of the housing and the lancets in the unused state are completely surrounded by the housing. Furthermore, an extension unit is movably connected to the housing in such a manner that the housing can be extended by movement of the extension unit in the direction of the distal end of the housing such that the lancet is prevented from emerging from the lancet magazine.. ... Roche Diagnostics Operations Inc

06/04/15 / #20150150494

Device for performing at least one medical function

A device for performing at least one medical function on a user is proposed. The device has at least one medical functional element that is designed to perform the medical function. ... Roche Diagnostics Operations Inc

05/28/15 / #20150148536

New bis-iridium-complexes for manufacturing of ecl-labels

The present invention relates to novel bis-iridium-based ir(iii) complexes, labels manufactured using these complexes and a method for producing such complexes.. . ... Roche Diagnostics Operations Inc

05/28/15 / #20150147752

New iridium-based complexes for ecl

The present invention relates to novel iridium-based ir(iii) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. In the electrochemiluminescence based detection of an analyte.. ... Roche Diagnostics Operations Inc

05/28/15 / #20150147751

New iridium-based complexes for ecl

The present invention relates to novel iridium-based ir(iii) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. In the electrochemiluminescence based detection of an analyte.. ... Roche Diagnostics Operations Inc

05/28/15 / #20150147750

New iridium-based complexes for ecl

The present invention relates to novel iridium-based ir(iii) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. In the electrochemiluminescence based detection of an analyte.. ... Roche Diagnostics Operations Inc

05/21/15 / #20150141870

Method for producing a membrane ring or test strip ring and ring magazine

A method for producing a membrane ring or test strip ring for a diagnostic test device includes an elongate strip that is divided into segments by cuts running transversely to the longitudinal direction of the strip, where the cuts are made only as far as a residual width of the strip so that a material bridge remains intact between the segments adjacent to the cuts (24). The strip is closed by bringing its ends together to form a ring where the cut edges of the cuts running towards the material bridges each enclose an acute angle (α). ... Roche Diagnostics Operations Inc

05/21/15 / #20150140682

Iridium-based complexes for ecl

The present invention relates to novel iridium-based ir(iii) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. In the electrochemiluminescence based detection of an analyte.. ... Roche Diagnostics Operations Inc

05/21/15 / #20150140669

Cartridge for dispensing a fluid

A cartridge for dispensing fluid is presented. The cartridge comprises a valve. ... Roche Diagnostics Operations Inc

05/21/15 / #20150140584

Reagent materials and associated test elements

Reagent materials and associated test elements are provided. In one embodiment, a test element having dual functionality includes a first coenzyme-dependent enzyme or a substrate for the first enzyme, a second coenzyme-dependent enzyme or a substrate for the second enzyme, and a coenzyme selected from the group consisting of thio-nad, thio-nadp, and a compound according to formula (i). ... Roche Diagnostics Operations Inc

05/21/15 / #20150140582

Immunological test element with improved control zone

The invention concerns a test element for carrying out an immunological sandwich test for determining an analyte from a liquid sample containing a reagent zone or conjugate zone which contains a conjugate of an analyte binding partner and a label which can be detected directly or indirectly by visual, optical or electrochemical means (e.g. An enzyme, fluorescent or direct label etc.) wherein said conjugate can be dissolved by the liquid sample, a detection zone which contains a permanently immobilized (i.e. ... Roche Diagnostics Operations Inc

05/21/15 / #20150140561

Compound for sequencing by synthesis

The present invention provides deoxynucleoside tri- or tetraphosphate comprising a 3′ nitrate and a detectable label covalently bound to the oxygen atom of an oxymethyl or oxyallyl or oxypropargyl substitution of a nucleobase. Such compounds provide new possibilities for future sequencing by synthesis technologies.. ... Roche Diagnostics Operations Inc

05/07/15 / #20150126401

Calprotectin and hemoglobin/haptoglobin complex from stool sample to assess colorectal cancer

The present invention relates to a method aiding in the assessment of colorectal cancer. The method especially is used in assessing the absence or presence of colorectal cancer in vitro. ... Roche Diagnostics Operations Inc

04/30/15 / #20150118759

System and method for display type detection of a handheld medical device

A device which supports identification of an integrated display and dynamic adjustments to operating parameters thereof includes: a port that receive a test strip having a reaction site for receiving a sample of fluid from a patient, a blood glucose (bg) meter cooperatively operable with a test strip inserted in the port to measure glucose in a sample of fluid on the test strip, and a display device having an electrically resistive component integrated therein and operable to display the glucose measurement in accordance with one or more operating parameters associated with the display device the system also includes a monitoring module electrically connected to the resistive component, wherein the monitoring module determines a type for the display device based on a resistance of the resistive component and a control module that selectively adjusts a given operating parameter of the display device in accordance with the type of display device.. . ... Roche Diagnostics Operations Inc

04/30/15 / #20150118534

Battery well for a medical testing device

An electronic device may include a battery well and a plurality of tabs. The battery well may receive a disk-shaped battery and may include an annular sidewall, an open end, an end wall and a recess. ... Roche Diagnostics Operations Inc

04/23/15 / #20150111236

Method and device for detecting an analyte in a body fluid

A method for detecting at least one analyte in at least one sample of a body fluid is disclosed. Therein, at least one test element (124) is used, the at least one test element (124) having at least one test field (162) with at least one test chemistry (154) is used, wherein the test chemistry (154) is adapted to perform at least one optically detectable detection reaction in the presence of the analyte. ... Roche Diagnostics Operations Inc

04/16/15 / #20150104876

Release reagent for vitamin d compounds

The present invention concerns a reagent composition for releasing vitamin d compounds bound to vitamin d-binding protein, a method for the detection of a 25-hydroxyvitamin d compound in which the 25-hydroxyvitamin d compound is released from vitamin d-binding protein using this reagent and the mixture obtained in this manner is analyzed, the use of the reagent to release vitamin d compounds as well as a kit for detecting 25-hydroxyvitamin d which contains the reagent for releasing vitamin d compounds in addition to the usual immunological reagents.. . ... Roche Diagnostics Operations Inc

04/16/15 / #20150104350

Apparatus for separating cuvettes

An apparatus, system for analyzing, and process for separating cuvettes supplied in bulk form are presented. The apparatus comprises a reservoir with an inlet for supplying cuvettes in bulk form to a reservoir space, a separator with an outlet for outputting separated cuvettes from a separator space communicating with the reservoir space, a reservoir spiral contained in the reservoir space to transport cuvettes to the separator space by rotating the reservoir spiral, and a separator spiral contained in the separator space to transport cuvettes to the outlet by rotating the separator spiral. ... Roche Diagnostics Operations Inc

04/09/15 / #20150099954

Sensor elements for detecting an analyte in a body fluid sample as well as methods of making the same

Sensor elements are provided for determining at least one analyte concentration in a body fluid. The sensor elements are at least partially implantable into a body tissue and have a substrate and at least two electrodes. ... Roche Diagnostics Operations Inc

04/09/15 / #20150096888

Bg meter lens attachment and seal

A blood glucose test device with viewing lens seal includes a meter body rigid portion of a first polymeric material and an opening. A resilient portion of a second polymeric material more compressible than the first polymeric material integrally connected to the rigid portion defines a rigid portion outer covering. ... Roche Diagnostics Operations Inc

04/02/15 / #20150095042

High/low blood glucose risk assessment systems and methods

A blood glucose (bg) measurement engine selectively measures bg levels in blood samples input to a handheld diabetes management device. A computer readable medium includes code executed by a processor to: identify a period of n days, the period including the current date and n−1 days immediately prior to the current date, wherein n is an integer greater than 6; determine a total number of the n days during which the patient input at least two blood samples; and, when the total number of the n days is greater than m, m being an integer greater than zero and less than or equal to n: calculate a value based on the bg levels of blood samples input during the period; based on the value, classify the patient as having a first, second, or third risk of being hypoglycemic in the future.. ... Roche Diagnostics Operations Inc

04/02/15 / #20150094688

Disposable inserter for use with a medical device

An inserter and methods of using embodiments of the inserter are described. The inserter includes a housing having a cannula assembly and an insertion mechanism. ... Roche Diagnostics Operations Inc

04/02/15 / #20150093771

Microfluidic analytical device for analysis of chemical or biological samples, method and system thereof

An analytical device for analysis of chemical or biological samples, a method of using such a device, based on rotation of the device, integrated sample dosing and optical detection, and a system comprising such a device are disclosed. The analytical device comprises a device body having a liquid processing unit. ... Roche Diagnostics Operations Inc

03/26/15 / #20150086990

Detection of bacterial (mollicutes) contamination

The present disclosure provides a method and system for the pcr amplification of a target sequence which suppresses non-specific amplification products. The disclosure concerns the use of a primer pair optimized to amplify a nucleic acid of a contaminant in the background of genomic dna of a first organism. ... Roche Diagnostics Operations Inc

03/26/15 / #20150082754

Carrier element and packaging device for packaging at least one product into at least one package

A carrier element for use in a packaging device is provided wherein the carrier element is connectable with at least one transport device of the packaging device. The carrier element comprises at least one receiving surface for receiving at least one package. ... Roche Diagnostics Operations Inc

03/19/15 / #20150080843

Manually operable portable infusion device

A portable therapeutic fluid delivery device and a method for delivering a therapeutic fluid into a body of a patient are provided. In one aspect the therapeutic fluid delivery device and the method can be implemented using at least one housing securable to the body of the patient, a reservoir coupled to the at least one housing, a therapeutic fluid dispensing mechanism, a memory component, a controller, at least one bolus delivery button configured to signal the controller to initiate the delivery of the therapeutic fluid into the body of the patient; and, an inadvertent initiation prevention mechanism adapted for preventing the patient from activating the at least one bolus delivery button.. ... Roche Diagnostics Operations Inc

03/19/15 / #20150080690

Sensor cartridge and inserter

A sensor cartridge comprising a sterile capsule. The sensor cartridge further comprises a sensor within the sterile capsule. ... Roche Diagnostics Operations Inc

03/19/15 / #20150080689

Method for making a dry sensor element for an enzymatic determination of an analyte in a body fluid and a dry sensor element

A method for making a dry sensor element for an enzymatic determination of an analyte in a body fluid includes providing a substrate, producing a working electrode on the substrate, producing a counter electrode on the substrate, and producing electric connectors on the substrate connected to the working electrode and the counter electrode, the step of producing the working electrode further comprising depositing an active enzymatic electrode layer containing an enzyme and a catalyzer material for catalyzing an enzymatic determination of an analyte of a body fluid, the catalyzer material comprising at least one of metal nano-particles and metal oxide nano-particles. A dry sensor element for an enzymatic determination of an analyte in a body fluid is also disclosed.. ... Roche Diagnostics Operations Inc

03/19/15 / #20150080684

Sensor insertion assembly, sensor cartridge, and inserter

A sensor insertion assembly comprising a sensor cartridge having an insertion needle and a sensor within a sterile capsule. The sensor insertion assembly further comprises an inserter comprising a chamber for receiving the sensor cartridge, wherein the inserter further comprises an insertion mechanism operable for actuating the insertion needle for inserting the sensor into a subject. ... Roche Diagnostics Operations Inc

03/19/15 / #20150079689

Displaying glucose measurements on a handheld glucose meter

A computer-implemented method is provided for displaying glucose measurements of a person on a handheld glucose meter. The method includes: determining a current blood glucose measurement for a person from a test strip inserted into a port of the handheld glucose meter; displaying the current glucose measurement on a result screen of the handheld glucose meter immediately following the measurement of the current glucose measurement by the handheld glucose meter; providing an indicium of a logbook screen on the result screen concurrently with the display of the current glucose measurement on the result screen; and displaying the logbook screen in response to a user input received by the handheld glucose meter, where the logbook screen displays the current glucose measurement along with at least two preceding glucose measurements of the person.. ... Roche Diagnostics Operations Inc

03/19/15 / #20150079685

Method and apparatus for accelerating the equilibration of a fluid

A method and an apparatus for accelerating the equilibration of a fluid, typically the reference fluid of an analyzer, are provided, the surface of the fluid being in contact with a gas phase. The device can comprise a cassette, which can be exchangeably inserted into an analyzer and which holds at least one flexible, gas-tight bag, in which the fluid and the gas phase are accommodated. ... Roche Diagnostics Operations Inc

03/19/15 / #20150079684

Tube rotator

A tube rotator for rotating test tubes arranged in a tube rack as well as a system and process for reading information of machine-readable labels of the test tubes are disclosed. The tube rotator may comprise a pivoted lever having two lever arms, a friction wheel rotatably fixed to one lever arm and arranged to be brought in or out of contact with at least one test tube for rotating the test tube by friction. ... Roche Diagnostics Operations Inc

03/19/15 / #20150079615

Use of biomarkers in the assessment of the early transition from arterial hypertension to heart failure

Methods and systems for diagnosing functional and/or structural abnormalities of the heart preceding heart failure, and for predicting the risk of developing heart failure, in a subject comprising measuring a cardiac troponin in a sample and comparing the measurement to a reference value. Other markers, including gdf15 and igfbp7 are also measured in some embodiments.. ... Roche Diagnostics Operations Inc

03/19/15 / #20150079604

Soluble immunoreactive treponema pallidum tpn47 antigens

The invention concerns soluble variants of treponema pallidum antigen 47 (tpn47 antigen) comprising at least domain b, or at least domains a and b, optionally domain d of the complete tpn47 protein molecule with the proviso that all antigens lack domain c (amino acid residues 224 to 351) of tpn47. The tpn47 antigens can be fused to a chaperone. ... Roche Diagnostics Operations Inc

03/19/15 / #20150076010

Encoded biosensors and methods of manufacture and use thereof

An analyte test sensor strip is disclosed having information coded thereon as well as a method of forming the same and conducting an analyte test using the analyte test sensor strip. Information relating to an attribute of the strip or batch/lot of strips may be coded based on resistance values pertaining to electrical aspects of the strip, such as a primary resistive element and a secondary resistive element, the secondary resistive element having one of a plurality of states defined by a location of a closed tap to form a unique resistive path for the secondary resistive element that includes a portion of the primary resistive element depending on the location of the closed tap. ... Roche Diagnostics Operations Inc

03/19/15 / #20150076004

Systems and methods for multiple analyte analysis

Systems and methods for multiple analyte analysis are provided. In one embodiment, a method includes determining concentrations of first and second analytes in a sample. ... Roche Diagnostics Operations Inc

03/12/15 / #20150072355

Flap endonuclease-1 as a marker for cancer

Methods aiding in the assessment of cancer comprising use of the flap endonuclease-1 protein (=fen1) as a universal marker of different cancer types are provided. In particular, methods for assessing cancer from a liquid sample derived from an individual, which comprise measuring fen1 in the sample are disclosed. ... Roche Diagnostics Operations Inc

03/12/15 / #20150069893

Installation of analytical apparatus

An analytical apparatus to be installed on a substantially horizontal surface of a diagnostic laboratory is presented. The apparatus comprises a bottom side and an upper working side, the bottom side having at least three casters for rolling the apparatus on a surface and at least two feet. ... Roche Diagnostics Operations Inc

03/05/15 / #20150066382

Method and analysis system for processing biological samples

A method for guiding user input on a computer system of an analysis system that includes an in vitro diagnostic, ivd, device. The ivd device is coupled to the computer system that includes a display, processor, and memory to store applications being executable on the processor. ... Roche Diagnostics Operations Inc

03/05/15 / #20150061890

Presenting data generated by a continuous glucose monitor

A computer implemented method for transmitting messages generated by a continuous glucose monitor (cgm), the method comprising: generating a first message at the cgm at a first time, the first message being related to blood glucose measuring; generating a second message at the cgm at a second time, the second time being after the first time, the second message being related to blood glucose measuring; determining an elapsed time since a transmitter of the cgm has transmitted data; determining whether the elapsed time is greater than a threshold; determining whether the second message is to be transmitted before the first message, in response to the elapsed time being greater than the threshold; and transmitting data corresponding with the second message before transmitting data corresponding with the first message to a diabetes management device, in response to determining that the second message is to be transmitted before the first message.. . ... Roche Diagnostics Operations Inc

02/26/15 / #20150057616

Hand-held injection devices and methods of use

At least one hand-held injection device for the metered injection of a liquid drug into a person's tissue is disclosed. The exemplary injection device comprises an elongated drug reservoir having a longitudinal reservoir axis (a), an elongated dosing unit having a dosing unit inlet, a dosing unit outlet, and a metering cavity, the dosing unit having a longitudinal dosing unit axis (a′), the elongated drug reservoir being fluidically coupled to the dosing unit inlet. ... Roche Diagnostics Operations Inc

02/26/15 / #20150056642

Armet as a marker for chronic obstructive pulmonary disease (copd)

An in vitro method aiding in the assessment of chronic obstructive pulmonary disease (copd). The disclosure further relates to a method for assessing copd from a sample, derived from an individual, by measuring the protein armet in said sample in vitro.. ... Roche Diagnostics Operations Inc

02/26/15 / #20150053564

Method for making a dry sensor element for an enzymatic determination of an analyte in a body fluid, dry sensor element and article

A method for making a dry sensor element for an enzymatic determination of an analyte in a body fluid includes providing a substrate, producing a working electrode on the substrate, comprising depositing an active enzymatic electrode layer on a working electrode base structure provided on the substrate, the active enzymatic electrode layer containing an enzyme, producing a counter electrode on the substrate, and producing electric connectors on the substrate connected to the working electrode and the counter electrode, wherein the step of depositing the active enzymatic electrode layer on the working electrode base structure comprises depositing pedot:pss by electropolymerization. A dry sensor element for an enzymatic determination of an analyte in a body fluid is also disclosed.. ... Roche Diagnostics Operations Inc

02/19/15 / #20150050186

Valve for dispensing a fluid

A valve for dispensing a fluid comprising a dry portion and a wet portion is presented. Only the wet portion is contacted by the fluid. ... Roche Diagnostics Operations Inc

02/19/15 / #20150048119

Microfluidic dispenser, cartridge and analysis system for analyzing a biological sample

A dispenser for dispensing a fluid is presented. The dispenser comprises a compressible elastomeric fluid conduit having a first end and a second end for flowing the fluid from the first end to the second end, a first check valve and a second check valve distanced in the conduit for forming a fluid chamber, and an actor for compressing the fluid chamber for dispensing a portion of the fluid. ... Roche Diagnostics Operations Inc

02/12/15 / #20150046114

Sensitivity and the dynamic range of photometric assays by generating multiple calibration curves

A method for determining the amount of a specific analyte by photometric assays, wherein the specific analyte in a sample reacts with an analyte specific reaction partner in a reaction mixture. At least two calibration curves are generated, the first calibration curve recorded at a first wavelength is optimized for low concentrations of the specific analyte thereby maximizing the lower detection limit and, the second calibration curve recorded at a second wavelength is optimized for high concentrations of the specific analyte thereby maximizing the upper detection limit. ... Roche Diagnostics Operations Inc

02/12/15 / #20150044780

Multi-application approach for photometric determination of an analyte in a fluid sample on an automated analyzer

A method for determining the amount of specific analyte of a sample which may show interferences by photometric assays, wherein the analyte is quantified from the change in the optical signal of the reaction mixture after the interaction of the analyte with analyte specific reagents. Multiple calibration curves are generated for multiple wavelengths for the specific analyte. ... Roche Diagnostics Operations Inc

02/05/15 / #20150039007

Methods and structures for assembling lancet housing assemblies for handheld medical diagnostic devices

A method of assembling a lancet housing assembly comprising multiple lancets for use in a portable handheld medical diagnostic device for sampling bodily fluids from a skin site of a patient is disclosed. The method includes forming a plurality of lancet structures in a lancet sheet. ... Roche Diagnostics Operations Inc

02/05/15 / #20150038814

Amperometric sensor and method for its manufacturing

An in vivo amperometric sensor is provided for measuring the concentration of an analyte in a body fluid. The sensor comprises a counter electrode and a working electrode, and the working electrode comprises a sensing layer which is generally water permeable and arranged on a support member adjacent to a contact pad. ... Roche Diagnostics Operations Inc

02/05/15 / #20150037898

Devices and methods of determining disturbance variable-corrected analyte concentrations

Devices and methods are provided for determining concentration of at least one analyte in a body fluid sample such as blood, especially a blood glucose concentration. In the methods, a test element is provided that has at least one reagent element configured so as to carry out at least one optically detectable detection reaction in the presence of the analyte. ... Roche Diagnostics Operations Inc

01/29/15 / #20150028109

Orientation identification label, reagent container carrier structure, analyzer device and reader module

A reagent container carrier structure for holding at least one reagent container, wherein the carrier structure has thereon an rfid assembly and an optically detectable definition pattern defining an orientation of the carrier structure, is disclosed. The reagent container carrier structure may have an orientation identification label that has a front surface and a back surface, and further include an rfid assembly positioned on the back surface, and an optically detectable definition pattern defining an orientation of the label on the front surface. ... Roche Diagnostics Operations Inc

01/29/15 / #20150027639

Devices for producing a tape product having diagnostic aids

A method for producing an analysis tape for fluid samples, in particular body fluids, is proposed. The method comprises providing a laminate tape having a laminate carrier tape and at least one diagnostic functional layer, and cutting the laminate tape in such a way that a diagnostic auxiliary label arises; transferring the diagnostic auxiliary label to a vacuum roller; and transferring the diagnostic auxiliary label to a carrier tape. ... Roche Diagnostics Operations Inc

01/22/15 / #20150024948

Method for detecting balanced chromosomal aberrations in a genome

The present disclosure provides methods and systems for the capture and enrichment of target nucleic acids and analysis of the enriched target nucleic acids for detecting balanced chromosomal aberrations including translocations and inversions. The present disclosure provides for the enrichment of targeted sequences in a format whereby one fusion partner gene on a capturing platform is represented to allow subsequent sequencing of chimeric nucleic acids (i.e., nucleic acid strands that carry information on different dna regions of a genome). ... Roche Diagnostics Operations Inc

01/22/15 / #20150024506

Release reagent for vitamin d compounds

A reagent composition for releasing vitamin d compounds bound to vitamin d-binding protein, an in vitro method for the detection of a vitamin d compound in which the vitamin d compound is released from vitamin d-binding protein by the use of this reagent composition and the reagent mixture obtained in this manner. The use of the disclosed reagent composition to release vitamin d compounds as well as a kit for detecting a vitamin d compound which contains the reagent composition for releasing vitamin d compounds in addition to common detecting reagents.. ... Roche Diagnostics Operations Inc

01/22/15 / #20150024429

Method and device for the homogeneous distribution of suspended cell components

A method for the homogeneous distribution of cell components suspended in a liquid on a surface and a device for the implementation thereof.. . ... Roche Diagnostics Operations Inc

01/15/15 / #20150016937

Transport device

A device is presented in which individual sample containers can be conveyed from a start position to a target position. The role of start position and target position is interchangeable. ... Roche Diagnostics Operations Inc

01/08/15 / #20150012223

Reminder, classification, and pattern identification systems and methods for handheld diabetes management devices

A method includes: measuring a blood glucose (bg) level in a blood sample; storing the bg level and a time of receipt of the blood sample; storing a classification of the blood sample; in response to the receipt of the blood sample, selecting a group of stored bg levels having the classification of the blood sample and that were received within a predetermined period before receipt of the blood sample; calculating a bg evaluation parameter from the selected bg levels; evaluating the bg evaluation parameter in relation to first predetermined criteria, the first predetermined criteria including a first threshold indicative of a high bg level or a low bg level; selectively displaying an indication of recognition of a pattern in the selected bg levels when the bg evaluation parameter is greater than or less than the first threshold; and selectively removing the indication from the display.. . ... Roche Diagnostics Operations Inc

01/08/15 / #20150012027

Lancing actuator

A lancing actuator (114) includes a drive element (118) for driving a lancing element, the drive element being guided within a housing (112), a combined compression and torsion element (120) which, by a relaxing movement thereof, is adapted to drive the lancing motion, a combined triggering and driving device (122) having an actuating element (124) and a locking device (126), wherein the actuating element has an initial state and an actuated state and is accessible from the outside of the housing, wherein, in the initial state, the drive element is locked in the locking device under a torsional stress exerted by the combined compression and torsion element, wherein the combined triggering and driving device is configured in a manner that, when the actuating element makes a movement along an actuation path from the initial state into the actuated state, a torque is exerted on the drive element which prevails over the torsional stress exerted by the combined compression and torsion element such that the drive element is released from the locking device, which results in a triggering of the lancing motion.. . ... Roche Diagnostics Operations Inc

01/08/15 / #20150008141

Enzyme stabilization in electrochemical sensors

The present invention relates to a composition for forming an electrode, an electrochemical sensor comprising the same, and a method for determining an analyte using the electrochemical sensor.. . ... Roche Diagnostics Operations Inc

01/01/15 / #20150005605

Diffusion barriers and spacer membranes for enzymatic in-vivo sensors

An electrode system is disclosed for measuring a concentration or presence of an analyte under in-vivo conditions, where the electrode system includes at least one electrode with immobilized enzyme molecules and an improved diffusion barrier that controls diffusion of the analyte from body fluid surrounding the electrode system to the enzyme molecules. The diffusion barrier includes a hydrophilic polyurethane or a block copolymer having at least one hydrophilic block and at least one hydrophobic block. ... Roche Diagnostics Operations Inc








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