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Roche Molecular System Inc patents


Recent patent applications related to Roche Molecular System Inc. Roche Molecular System Inc is listed as an Agent/Assignee. Note: Roche Molecular System Inc may have other listings under different names/spellings. We're not affiliated with Roche Molecular System Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "R" | Roche Molecular System Inc-related inventors


Sealable microfluidic chip for thermocycling

The present disclosure relates to reversible sealing of a microfluidic chip used for thermal incubation of an aqueous sample suspected to contain a target nucleic acid. The microfluidic chip contains a flow channel and a plurality of reaction compartments, into which the sample and a displacement fluid are introduced through an inlet port sealable by means of a sealing agent having a melting point above room temperature.. ... Roche Molecular System Inc

Device and method for biological sample collection and inspection

A device is described including a lid, a collection portion support, and a collection portion with a surface for receiving a biological sample, the lid includes a window and a window holder, the surface defines a first plane, the collection portion includes a first, a second, and a third position markers, each position marker indicates a center point marker, the center points define a second plane that has a line of intersection with the first plane, the device has an interior volume defined partially by the collection portion support, the collection portion, the window, and the window holder, the window allows visual inspection of the position markers, the collection portion support has a fluid inlet and a fluid outlet with a fluid path from the fluid inlet to the fluid outlet via the interior volume.. . ... Roche Molecular System Inc

Generic matrix for control nucleic acids

The present invention belongs to the field of in-vitro diagnostics. Within this field, it particularly concerns the amplification of at least a first target nucleic acid that may be present in at least one fluid sample using an internal control nucleic acid for qualitative and/or quantitative purposes and at least one external control nucleic acid in an aqueous buffer. ... Roche Molecular System Inc

Dna polymerases with increased 3'-mismatch discrimination

Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. ... Roche Molecular System Inc

Systems & methods for detecting cells using engineered transduction particles

Accurate measurements of the presence or absence of a target cell in a sample are provided. For example, the sample can be mixed with a plurality of transduction particles capable of binding to the target cells, the transduction particles being engineered to include a nucleic acid molecule formulated to cause the target cells to produce a plurality of detectable reporter molecules once the particles bind to and deliver the nucleic acid molecules into the one or more target cells. ... Roche Molecular System Inc

Reversibly protected nucleotide reagents with high thermal stability

The present invention provides for stable nucleotide reagents used for nucleic acid amplification by pcr and rt-pcr (reverse transcriptase-pcr) that comprises modified nucleoside polyphosphates. The present invention also provides for methods for using the modified nucleoside polyphosphates for detecting the presence or absence of a target nucleic acid sequence in a sample in an amplification reaction.. ... Roche Molecular System Inc

Instrument and method for automatically heat-sealing a microplate

A heating device for heating a thermally fixable sealing cover disposed over the microplate adjacent the wells, a cooling device for actively cooling the microplate and a controller set up to control activity of the heating and cooling devices in a manner to heat the sealing cover so as to thermally fix it to the microplate and to actively cool the microplate so as to keep a temperature of the samples below a predefined temperature when heating the sealing cover. It further relates to a method for automatically sealing a microplate in which the thermally fusible sealing cover is disposed over the microplate, the sealing cover is heated to thermally fix it to the microplate and the microplate is actively cooled in a manner that a temperature of the liquid reaction mixtures is kept below a predefined temperature when heating the sealing cover.. ... Roche Molecular System Inc

Compositions and methods for detecting mecc-containing methicillin-resistant staphylococcus aureus

Methods for the rapid detection of the presence or absence of mecc-containing staphylococcus aureus (mecc-mrsa) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. ... Roche Molecular System Inc

Analytical system with accurate positioning of multiwell plates

The present disclosure relates to an analytical system with at least three components: a multiwell plate on which the wells are included in an optically transparent area; a frame holding the multiwell plate close to its edge while permitting the plate a certain extent of freedom of movement; a baseplate to which the multiwell plate, but not the frame is firmly fixed via a docking mechanism, such that different expansion of plate and frame can be compensated. A second aspect described herein relates to a method of docking a corresponding multiwell plate held by a frame to a baseplate and subjecting the multiwell plate to a step of a biological or chemical assay within this arrangement.. ... Roche Molecular System Inc

Generic sample preparation

The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids in a simultaneous manner.. ... Roche Molecular System Inc

Dna polymerases with increased 3’-mismatch discrimination

Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. ... Roche Molecular System Inc

Dna polymerases with increased 3'-mismatch discrimination

Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. ... Roche Molecular System Inc

Methods for determining the amount of a nucleic acid of interest in an unprocessed sample

The present disclosure relates to methods for determining the amount or concentration of a nucleic acid of interest in an unprocessed sample by analyzing a processed sample and a reference sample with digital polymerase chain reaction (dpcr).. . ... Roche Molecular System Inc

Dna polymerases with increased 3'-mismatch discrimination

Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. ... Roche Molecular System Inc

05/17/18 / #20180135033

Dna polymerases with improved activity

Disclosed are dna polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. ... Roche Molecular System Inc

05/10/18 / #20180129781

Detection of sequence variants

Systems, methods, and apparatuses are provided for detecting nucleic acid sequence variants. Other embodiments are directed to systems and computer readable media associated with methods described herein.. ... Roche Molecular System Inc

05/10/18 / #20180127838

Compositions and methods for detection of bk virus

Methods for the rapid detection of the presence or absence of bk virus in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. ... Roche Molecular System Inc

05/03/18 / #20180119117

Dna polymerases with increased 3'-mismatch discrimination

Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. ... Roche Molecular System Inc

05/03/18 / #20180119116

Dna polymerases with increased 3'-mismatch discrimination

Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. ... Roche Molecular System Inc

04/12/18 / #20180100205

Phi6 internal control compositions, devices & methods

The disclosure provides control compositions used in nucleic acid amplification. Various modifications to the disclosed compositions and methods of using the same, devices, and kits are described.. ... Roche Molecular System Inc

04/05/18 / #20180095046

Sensor for detecting a state of a fluid within a microfluidic plate, system for controlling a preparation of a sample including a fluid and method for detecting a state of a fluid within a microfluidic plate

A sensor (100) for detecting a state of a fluid within a microfluidic plate (120) is disclosed. The sensor (100) comprises at least a first planar electrode (102) and a second planar electrode (104) arranged parallel to one another so as to form an electric capacitor (106). ... Roche Molecular System Inc

04/05/18 / #20180094249

Polymerase variants

The present disclosure provides variant pol6 polymerase polypeptides, compositions comprising the pol6 variant polypeptides, and methods for using the variant pol6 polypeptides for determining the sequencing of nucleic acids, for example, by nanopore sequencing. The variant pol6 polymerases possess decreased rates of dissociation of template from the polymerase-template complex, which result in increased processivity relative to the parental pol6 polypeptides from which they are derived.. ... Roche Molecular System Inc

04/05/18 / #20180093268

Microfluidic device and method for manufacturing the same

The present disclosure provides a microfluidic device (1) comprising at least one flow channel (21) connecting an inlet opening (22) with an outlet opening (23), and an array of wells (24) in fluid communication with the flow channel (21), wherein the flow channel (21) comprises an inlet portion (211) at the inlet opening (22), an outlet portion (212) at the outlet opening (23), and a middle portion (213) between the inlet portion (211) and the outlet portion (212), wherein at least the middle portion (213) comprises the array of wells (24) and is provided with a hydrophilic surface, and the flow channel (21) further comprises a transition area (214) provided at least between the middle portion (213) and the outlet portion (212), which transition area (214) is constituted by providing a hydrophobic surface. Furthermore, a method for manufacturing such a microfluidic device is also provided.. ... Roche Molecular System Inc

03/29/18 / #20180087090

Method for reducing quantification errors caused by reaction volume deviations in digital polymerase chain reaction

. . The present disclosure relates to a method for reducing quantification errors caused by reaction volume deviations in digital polymerase chain reaction (dpcr) and to a method for determining the amount or concentration of a nucleic acid of interest in a sample with dpcr.. . ... Roche Molecular System Inc

03/15/18 / #20180073161

Nanopore forming method and uses thereof

The invention relates to a method for making nanopores in thin layers or monolayers of transition metal dichalcogenides that enables accurate and controllable formation of pore within those thin layer(s) with sub-nanometer precision.. . ... Roche Molecular System Inc

03/15/18 / #20180073064

Methods for performing multiplexed real-time pcr

The present invention describes methods for performing higher multiplexed real-time pcr for detection and quantitation of target nucleic acids using tagged hydrolysis probes.. . ... Roche Molecular System Inc

03/15/18 / #20180073056

Methods for performing multiplexed pcr

The present invention describes methods for performing higher multiplexed pcr for detection and quantitation of target nucleic acids using tagged hydrolysis probes.. . ... Roche Molecular System Inc

03/15/18 / #20180073011

Methods and compositions for purifying double stranded nucleic acids

Provided herein are methods and compositions to effectively isolate short, double-stranded nucleic acids on magnetic glass particles.. . ... Roche Molecular System Inc

03/15/18 / #20180073008

Reaction mixtures

The present invention provides stable dried reaction mixtures, methods for their preparation, methods for their use, and kits comprising them. The stable dried reaction mixtures are useful in many recombinant dna techniques, especially nucleic acid amplification by the polymerase chain reaction (pcr).. ... Roche Molecular System Inc

03/01/18 / #20180056300

Housing for laboratory instrument, laboratory instrument & method for assembling a laboratory instrument

A housing for a laboratory instrument is disclosed. The laboratory instrument comprises a base plate, wherein a holder configured to hold at least one consumable or a rack comprising at least one consumable is mounted onto said base plate, wherein the housing comprises a frame, wherein the frame is configured to support the base plate. ... Roche Molecular System Inc

03/01/18 / #20180056297

Assembly, instrument for performing a temperature-dependent reaction and method for performing a temperature-dependent reaction in an assembly

An assembly (10) comprising a sample block (12), a heat sink (30) and at least one electrodeposited thermoelectric element (48) is disclosed. Further, an instrument and a method for performing a temperature-dependent reaction are disclosed.. ... Roche Molecular System Inc

02/22/18 / #20180051325

Multiplex allele specific pcr assays for detection of estrogen receptor esr1 mutations

Provided herein are methods and compositions to detect mutations in estrogen receptor (esr1).. . ... Roche Molecular System Inc

02/15/18 / #20180045641

Plate with wells for chemical or biological reactions, and method for multiple imaging of such a plate by means of an imaging system

The present disclosure provides a plate comprising an array of wells for chemical or biological reactions, wherein each of the wells comprises a reaction chamber with at least one opening on a surface of the plate. The array of wells consist of a plurality of adjacent blocks of wells, wherein each block of wells consists of a plurality of adjacent rows of wells, and wherein at least one void is provided in each block of wells in between the rows of wells. ... Roche Molecular System Inc

02/15/18 / #20180044648

Dna polymerases with increased 3'-mismatch discrimination

Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. ... Roche Molecular System Inc

02/08/18 / #20180037945

Helper oligonucleotide for improved efficiency of amplification and detection/quantitation of nucleic acids

Improved methods for the detection and quantitation of a target nucleic acid in a sample using a non-extending helper oligonucleotide are described. The methods include contacting nucleic acids in a sample with amplification reagents including one or more primers, one or more non-extending helper oligonucleotides, and one or more probes. ... Roche Molecular System Inc

01/25/18 / #20180023063

Dna polymerases with increased 3'-mismatch discrimination

Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. ... Roche Molecular System Inc

01/11/18 / #20180010107

Dna polymerases with improved activity

Provided are dna polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of primer extension methods. ... Roche Molecular System Inc

01/11/18 / #20180010106

Dna polymerases with improved activity

Disclosed are dna polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. ... Roche Molecular System Inc

01/04/18 / #20180000023

System for separating and detecting an analyte

The present invention relates to an automated analytical system and an automated method for separating and detecting an analyte, as well as an automated analytical instrument.. . ... Roche Molecular System Inc

12/28/17 / #20170369856

Dna polymerases and related methods

Disclosed are mutant dna polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. ... Roche Molecular System Inc

12/14/17 / #20170356058

Compositions and methods for detection of hepatitis c virus genotype 3

Methods for the rapid detection of the presence or absence of hepatitis c virus (hcv) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. ... Roche Molecular System Inc

12/14/17 / #20170356025

Internal control probes for improving pcr assay performance

The present invention relates to methods for improving multiplex real-time pcr assays by the use of an internal control probe labeled with quasar 705.. . ... Roche Molecular System Inc

11/30/17 / #20170342508

Compositions and methods for detection of trichomonas vaginalis

Methods for the rapid detection of the presence or absence of trichomonas vaginalis (tv) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. ... Roche Molecular System Inc

11/30/17 / #20170342468

Compositions and methods for detection of mycoplasma genitalium

Methods for the rapid detection of the presence or absence of mycoplasma genitalium (mg) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. ... Roche Molecular System Inc

11/23/17 / #20170336428

Rfid tracking systems and methods

Improved component tracking methods and systems are disclosed herein. The use of suspended reagent and/or sample identifiers are described as well as the use of suspended and supplemental identifiers to enhance component tracking in assay systems.. ... Roche Molecular System Inc

11/23/17 / #20170336397

Rfid detection systems and methods

Improved detection and tracking methods and systems are disclosed herein. The use of rfid labels that are operably connected upon complex formation in a binding assay is described as well as the use of rfid labels and supplemental identifiers to enhance component tracking in assay systems.. ... Roche Molecular System Inc

11/23/17 / #20170335413

Cell surface marker depletion in a sample processing device

The disclosure provides methods, devices, and kits for conducting a quantitative analysis of a whole blood sample. Various modifications to the disclosed methods, devices, and kits are described.. ... Roche Molecular System Inc

11/16/17 / #20170327897

Methods and compositions for classifying dlbcl

Provided herein are methods and compositions to classify dlbcl subtypes using quantitative rt-pcr.. . ... Roche Molecular System Inc

11/16/17 / #20170327887

Detection of met exon 14 deletions and associated therapies

Provided herein are methods and compositions to detect met exon 14 skipping using rt-pcr, and methods of treating individuals with met exon 14 deleted cancers.. . ... Roche Molecular System Inc

11/16/17 / #20170327815

Protein-based sample collection matrices and devices

Provided herein are methods and compositions to effectively isolate nucleic acids using protein-based sample collection matrices.. . ... Roche Molecular System Inc

10/12/17 / #20170292145

Qualitative and quantitative detection of microbial nucleic acids

The present invention relates to new methods and uses for the qualitative and quantitative detection of microbial nucleic acids using at least a first control nucleic acid, or a first and a second control nucleic acid in different concentrations. The method is based on amplification of nucleic acids, for example the polymerase chain reaction. ... Roche Molecular System Inc

10/05/17 / #20170283888

Use of rnase h for the selective amplification of viral dna

The present invention concerns the amplification of at least a first and a second target nucleic acid that may be present in at least one fluid sample using rnase h and a polymerase with reverse transcriptase activity.. . ... Roche Molecular System Inc

10/05/17 / #20170283790

Sample processing methods

A method of processing a sample may include introducing a sample into a vessel, the vessel having proximal and distal ends, the sample being introduced into the proximal end of the vessel; incubating the sample in the vessel with a substance capable of specific binding to a preselected component of the sample; propelling components of the incubated sample, other than the preselected component, toward the proximal end of the vessel by clamping the vessel distal to the incubated sample and compressing the vessel where the incubated sample is contained; propelling the preselected component toward a distal segment of the vessel by clamping the vessel proximal to the preselected component and compressing the vessel where the preselected component is contained; and mixing the preselected component with a reagent in the distal segment of the vessel.. . ... Roche Molecular System Inc

09/21/17 / #20170268074

Hev assay

A method of simultaneously amplifying genotypes 1, 2, 3 and/or 4 of hev is disclosed comprising amplifying the genotypes 1, 2, 3 and/or 4 of hev with one single none-degenerate forward primer partially overlapping the 5′utr region of hev and at least one reverse primer. Also disclosed are related methods comprising a probe, and kits for the detection of genotypes 1, 2, 3 and/or 4 of hev.. ... Roche Molecular System Inc

09/21/17 / #20170267995

Suspension container for binding particles for the isolation of biological material

A device, method and system is provided for binding particles for the separation and/or isolation of biological materials. In particular, a container is provided including a suspension of binding particles for the isolation of biological material, inner walls forming an elongate groove at the bottom of said container, and a cover having openings and/or being penetrable for a linear arrangement of multiple pipets or pipet tips, said openings being located above and parallel to said elongate groove.. ... Roche Molecular System Inc

09/14/17 / #20170260596

Compositions and methods for detection of zika virus

Methods for the rapid detection of the presence or absence of zika virus in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. ... Roche Molecular System Inc

09/07/17 / #20170253870

Device for separation

A device comprising a support part is disclosed. The support part is configured to receive a tip holder, a liquid waste container and a multiwell plate. ... Roche Molecular System Inc

08/24/17 / #20170241912

Optics for analysis of microwells

In one aspect of the present disclosure an optical measurement device includes a sample holder defining a sample plane, wherein the sample holder is configured to arrange a sample carrier including an array of measurement positions in the sample plane, an illumination unit configured to illuminate the sample plane, a detector and an optical imaging system configured to image the sample plane including the array of measurement positions onto the detector, the optical imaging system including two or more curved reflective elements adapted to image the sample plane onto the detector with a magnification of between 2:1 and 1:2 and the detector being configured to take an image of all measurement positions of the array of measurement positions at a time.. . ... Roche Molecular System Inc

08/17/17 / #20170233801

Methods and compositions for nucleic acid detection

Methods, compositions, reaction mixtures, kits, and/or systems for producing a complementary sequence to a region in a target polynucleotide in a sample are provided. In some aspects, the methods, compositions, reaction mixtures, kits, and/or systems comprise subjecting the sample to a nucleic acid amplification reaction in a reaction mixture under conditions to yield the complete sequence to the region of the target polynucleotide. ... Roche Molecular System Inc

08/03/17 / #20170220832

Method for teaching positioning of a bar code scanner & apparatus for processing a sample or reagent

A method for teaching positioning of a bar code scanner is disclosed. The method includes moving the bar code scanner relative to a first bar code so as to sweep a light beam emitted from the bar code scanner across the first bar code, detecting an orientation of the bar code scanner relative to the first bar code and positioning the bar code scanner based on the orientation. ... Roche Molecular System Inc

07/27/17 / #20170212079

Use of titanium nitride as a counter electrode

A nanopore cell includes a titanium nitride (tin) counter electrode configured to be at a first electric potential. The nanopore cell also include a working electrode configured to be at a second electric potential and an insulating wall. ... Roche Molecular System Inc

07/27/17 / #20170212078

Molded flow channel

A nanopore based sequencing system includes a plurality of nanopore sensors. Each nanopore sensor has a portion for receiving a fluid. ... Roche Molecular System Inc

07/20/17 / #20170204462

Multiplexed nucleic acid target identification by strucutre based probe cleavage

The present invention provides for novel methods and compositions for nucleic acid sequence detection. Unique, identifying cleavage fragments from probes, bound to target nucleic acids, are produced during pcr by the 5′-nuclease activity of the polymerase. ... Roche Molecular System Inc

07/13/17 / #20170197208

Pipetting device for an apparatus for processing a sample or reagent, apparatus for processing a sample or reagent & method for pipetting a sample or reagent

A pipetting device (100) for an apparatus for processing a sample or reagent is disclosed. The pipetting device (100) comprises a coupling mechanism, wherein the coupling mechanism comprises at least a first coupling unit (104) adapted to be coupled to a first pipetting tip (108) and a second coupling unit (106) adapted to be coupled to a second pipetting tip (110), and a selection element (138) for selectively allowing a coupling of the first coupling unit (104) to or releasing the first coupling unit (104) from the first pipetting tip (108) and for selectively allowing a coupling of the second coupling unit to or releasing the second coupling unit (106) from the second pipetting tip (110). ... Roche Molecular System Inc

07/06/17 / #20170191111

Detecting an analyte in a flash and glow reaction

Accurate measurements of the presence or absence of an analyte (e.g., mrsa) in a sample are provided. For example, the sample can be subjected to an activation reagent (potentially after an initial reagent has already been added), which can cause a flash signal that increases and then decreases over time. ... Roche Molecular System Inc

07/06/17 / #20170191053

Successive capture of nucleic acid by magnetic glass particles

Provided herein are methods and components for successive capture of nucleic acids using magnetic glass particles.. . ... Roche Molecular System Inc

07/06/17 / #20170191044

Dna polymerases with improved activity

Disclosed are dna polymerases having increased reverse transcriptase efficiency, mismatch tolerance, extension rate and/or tolerance of rt and polymerase inhibitors relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. ... Roche Molecular System Inc

06/29/17 / #20170183720

Generic method for the stabilization of specific rna

The present invention relates to methods and compositions for the stabilization of specific rna molecules that can either be the target for detection or the control standard.. . ... Roche Molecular System Inc

06/15/17 / #20170166953

Methods and kits for joining fragmented nucleic acids together

Methods and kits for joining fragmented nucleic acid sequences together are provided, including performing an amplifying step including contacting a sample suspected of including a fragmented target nucleic acid with a pair of external primers and a pair of self-complementary internal primers, and generating a full length target nucleic acid. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. ... Roche Molecular System Inc

06/01/17 / #20170153260

Laboratory instrument & method of using the same

Disclosed is a method of operating a laboratory instrument (100, 1000), wherein the laboratory instrument is configured for receiving a sample rack (112) with one or more sample tubes (126), wherein the laboratory instrument comprises a robotic head (106) for bringing a pipettor (108) into fluidic contact with the one or more sample tubes when the sample rack is in an operating position (122), wherein the robotic head is configured for loading the sample rack into the operating position, and wherein the method comprises the steps of: receiving (200) the sample rack by the laboratory instrument; and loading (202) the rack into the operating position using the robotic head.. . ... Roche Molecular System Inc

05/11/17 / #20170131317

Method for prevention of contamination

A method is provided for disposing of a liquid within an automated analytical system for processing a fluid biological sample, wherein a contamination prevention shield including channels for pipets or pipet tips is reversibly docked to a container for liquid waste in order to reduce the risk of cross-contamination. A tip rack assembly is provided for processing a fluid sample, the assembly including a rack for pipet tips and the contamination prevention shield. ... Roche Molecular System Inc

05/11/17 / #20170131314

Pipetting device for an apparatus for processing a sample or reagent, apparatus for processing a sample or reagent & method for pipetting a sample or reagent

A pipetting device (100) for an apparatus (164) for processing a sample or reagent is disclosed. The pipetting device (100) comprises a coupling mechanism (102), wherein the coupling mechanism (102) comprises at least a first coupling unit (104) adapted to be coupled to a first pipetting tip and a second coupling unit (106) adapted to be coupled to a second pipetting tip, and a tilt mechanism (112) for moving the first coupling unit (104) between an untilted position, in which the first coupling unit (104) and the second coupling unit (106) are arranged parallel to one another, and a tilted position, in which the first coupling unit (104) is tilted relative to the second coupling unit (106).. ... Roche Molecular System Inc

04/13/17 / #20170101632

Dna polymerases with improved activity

Disclosed are dna polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. ... Roche Molecular System Inc

04/13/17 / #20170100715

Instrument and method for the automated thermal treatment of liquid samples

An instrument and a method for the automated thermal treatment of liquid samples are disclosed. An inter-distance between a temperature-controlled receptacle for loading with a plurality of vessels for containing the samples and end portions of optical fibers can be varied, wherein the receptacle is configured to form a thermal communication with the loaded vessels and wherein the optical fibers have first and second end portions. ... Roche Molecular System Inc

04/06/17 / #20170096634

Mycobacteria pre-analytic reagent

A pre-analytic reagent is provided for liquefaction of a sputum sample and complete inactivation of one or more mycobacteria, e.g., mycobacterium tuberculosis (mtb) suspected of being contained in the sputum sample at room temperature. The pre-analytic reagent may include one or more of each of: a chaotropic agent, a chelator, a reducing agent, a detergent, and acetic acid. ... Roche Molecular System Inc

03/23/17 / #20170082543

Instrument and method for detecting analytes

. . The present disclosure provides an instrument and methods for detecting an analyte, comprising a light source capable of generating excitation light for exciting a plurality of luminescence labels, an excitation beam path extending between said light source and said analyte, a detector capable of detecting light emitted from said luminescence label, an emission beam path extending between said analyte and said detector, a filter carrier carrying two or more pairs of filter portions, each pair being related to one luminescence label and comprising a first filter portion for transmitting excitation light and a second filter portion for transmitting emitted light, wherein said first filter portion of one pair is said second filter portion of another pair, and wherein said filter portions are arranged in a manner that a respective one of said pairs can be brought in an operative condition in which said first filter portion is in said excitation beam path and said second filter portion is in said emission beam path, and wherein said filter carrier and said beam paths are movable with respect to each other by at least one moving mechanism so as to bring a respective one of said pairs in said operative condition.. . ... Roche Molecular System Inc

03/16/17 / #20170076046

Informatics platform for integrated clinical care

An informatics platform provides an architecture to integrate information from relevant patient information systems. The informatics platform may include: a workflow tool that can be used to prepare and review information at multi-disciplinary board meetings; a visual timeline of patient events; a search engine to search for patients with specific attributes; a graphing tool that can display disparate clinical variables in a single chart; a virtual pinboard for users to identify relevant patient information for board meetings; an image viewing application that can provide for comparison of images from different information systems; structured reporting functionality that incorporates system aggregated patient information and board recommendations; an application interface that integrates clinically relevant tools to provide patient specific references; a collaboration interface that facilitates communication of patient specific information and documents the discussion threads as independent reference points; and a default display of relevant patient information customized for each clinical specialty.. ... Roche Molecular System Inc

03/09/17 / #20170067122

Diagnostic test for susceptibility to b-raf kinase inhibitors

The present invention provides methods and reagents for the detection of a mutation in braf and methods of selecting patients for treatment if a b-raf kinase inhibitor, such as a selective b-raf kinase inhibitor.. . ... Roche Molecular System Inc

03/09/17 / #20170067114

Novel mutation in the epidermal growth factor receptor kinase domain

A new in-frame deletion was found in exon 19 of the egfr gene, the exon that is often mutated in tumors. The invention comprises methods of detecting the mutation, methods of prognosis and methods of predicting response to treatment based on the presence of absence of the mutation.. ... Roche Molecular System Inc

02/09/17 / #20170037452

Compositions and methods for detection of mycobacterium tuberculosis

Method for the rapid detection of the presence or absence of mycobacterium tuberculosis (mtb) and other members of the mtb-complex in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. ... Roche Molecular System Inc

02/02/17 / #20170029792

Dna polymerases with improved activity

Disclosed are dna polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. ... Roche Molecular System Inc

02/02/17 / #20170029791

Dna polymerases with improved activity

Disclosed are dna polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. ... Roche Molecular System Inc

01/26/17 / #20170023567

Identification of antigen epitopes and immune sequences recognizing the antigens

Methods, compositions, and reaction mixtures are provided for identifying a t cell receptor (tcr) and an epitope peptide that specifically binds the tcr. Methods, compositions, and reaction mixtures are also provided for identifying a plurality of t cell receptors and corresponding epitope peptides that specifically bind the t cell receptors. ... Roche Molecular System Inc








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