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Rubicon Genomics Inc patents


Recent patent applications related to Rubicon Genomics Inc. Rubicon Genomics Inc is listed as an Agent/Assignee. Note: Rubicon Genomics Inc may have other listings under different names/spellings. We're not affiliated with Rubicon Genomics Inc, we're just tracking patents.

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Methods and compositions for generating and amplifying dna libraries for sensitive detection and analysis of dna methylation

The present invention regards a variety of methods and compositions for obtaining epigenetic information, such as dna methylation patterns, through the preparation, amplification and analysis of methylome libraries. In particular, the method employs preparation of a dna molecule by digesting the dna molecule with at least one methylation-sensitive restriction enzyme; incorporating a nucleic acid molecule into at least some of the digested dna molecules by either (1) incorporating at least one primer from a plurality of primers that have a 5′ constant sequence and a 3′ variable sequence, wherein the primers are substantially non-self-complementary and substantially non-complementary to other primers in the plurality; or (2) incorporating an oligonucleotide having an inverted repeat and a loop under conditions wherein the oligonucleotide becomes blunt-end ligated to one strand of the digested dna molecule, followed by polymerization from a 3′ hydroxyl group present in a nick in the oligonucleotide-linked molecule; and amplifying one or more of the dna molecules. ... Rubicon Genomics Inc

Dna amplification and sequencing using dna molecules generated by random fragmentation

The present invention is directed to methods to prepare a dna molecule or a plurality of dna molecules by random fragmentation. In some embodiments, the present invention regards preparing a template for dna sequencing by random fragmentation. ... Rubicon Genomics Inc








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