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Salk Institute For Biological Studies patents


Recent patent applications related to Salk Institute For Biological Studies. Salk Institute For Biological Studies is listed as an Agent/Assignee. Note: Salk Institute For Biological Studies may have other listings under different names/spellings. We're not affiliated with Salk Institute For Biological Studies, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "S" | Salk Institute For Biological Studies-related inventors


Compositions and methods for treating age-related diabetes and related disorders

The invention features compositions and methods treating or preventing for age-related insulin resistance, type 2 diabetes and related disorders. The method involves depleting ftreg cells with an anti-st2 antibody to decrease age-related ftreg accumulation and restore insulin sensitivity, thereby treating age-related insulin resistance, type 2 diabetes and related disorders.. ... Salk Institute For Biological Studies

Motor neuron-specific expression vectors

The present disclosure relates to nucleic acid promoter sequences that are able to specifically express genes operatively linked to the promoter in brainstem and spinal motor neuron cells, and to methods for using such promoters to selectively express genes in motor neurons in vitro and in vivo. It is based, at least in part, on the discovery that the nucleic acid of seq id no: 1 functioned as a motor neuron-specific promoter and was successful in expressing transgenes in motor neuron cells in vivo. ... Salk Institute For Biological Studies

Treatment of steroid-induced hyperglycemia with fibroblast growth factor (fgf) 1 analogs

Methods of using fgf1 analogs, such as fgf1 mutant proteins having an n-terminal deletion, point mutation(s), or combinations thereof, to reduce blood glucose levels in subjects with steroid-induced diabetes, hypercortisolemia, or diabetes due to treatment with an antipsychotic agent, are provided. Such mutant fgf1 proteins can be part of a chimeric protein that includes a β-klotho-binding protein, an fgfr1-binding protein, a β-klotho-binding protein and a fgfr1-binding protein, a c-terminal region from fgf19 or fgf21.. ... Salk Institute For Biological Studies

Synthetic adenoviruses with tropism to damaged tissue for use in promoting wound repair and tissue regeneration

Synthetic adenoviruses having chimeric fiber proteins and liver detargeting mutations are described. The synthetic adenovirus vectors are capable of specifically infecting cells at wound sites or in regions of damaged tissue. ... Salk Institute For Biological Studies

Estrogen related receptor gamma (errgamma) enhances and maintains brown fat thermogenic capacity

Brown adipose tissue (bat) plays a role in keeping an organism warm in response to a cold environment. In response to cold, transcription factors, including peroxisome proliferator receptor alpha (pgc1α), mediate the adaptive changes in the expression of oxidative and thermogenic genes in bat. ... Salk Institute For Biological Studies

Vitamin d receptor agonists to treat diseases involving cxcl12 activity

Provided herein are methods of treating pancreatic ductal adenocarcinoma in a mammalian subject. In some examples, such methods include administering a therapeutically effective amount of a vdr agonist (such as calcipotriol and/or paricalcitol) and administering a therapeutically effective amount of one or more chemotherapeutic agents, wherein the one or more chemotherapeutic agents comprise gemcitabine, 5-fluorouracil, cisplatin, protein-bound paclitaxel, and a pd-1 monoclonal antibody and/or pdl-1 monoclonal antibody.. ... Salk Institute For Biological Studies

Methods for treating metabolic disorders using fgf

The method provides methods and compositions for treating metabolic disorders such as impaired glucose tolerance, elevated blood glucose, insulin resistance, dyslipidemia, obesity, and fatty liver.. . ... Salk Institute For Biological Studies

Mutated fibroblast growth factor (fgf) 1 and methods of use

The present disclosure provides fgf1 mutant proteins, such as those having an n-terminal deletion, point mutation(s), or combinations thereof, which can reduce blood glucose in a mammal. Such mutant fgf1 proteins can be part of a chimeric protein that includes a β-klotho-binding protein, an fgfr1c-binding protein, a β-klotho-binding protein and a fgfr1c-binding protein, a c-terminal region from fgf19 or fgf21. ... Salk Institute For Biological Studies

Use of phospholipid scramblase inhibitors for modulating inflammatory immune responses

The finding that phosphatidylserine (ptdser) exposure on the outer leaflet of virally transduced cells triggers their engulfment by resident immune cells is described. It is demonstrated that inhibition of phospholipid scramblase 1 (plscr1) activity prevents ptdser externalization and enables prolonged protection of vector-transduced cells from phagocytosis. ... Salk Institute For Biological Studies

Selective cell targeting using adenovirus and chemical dimers

Compositions and methods for retargeting adenovirus to a cell using chemical dimers are described. In particular, a recombinant adenovirus comprising a nucleic acid comprising a capsid-dimerizing agent binder conjugate and a ligand-dimerizing agent binder conjugate is provided.. ... Salk Institute For Biological Studies

Adenoviral tumor diagnostics

Compositions and methods for detecting a cancer in a subject using a recombinant reporter adenovirus are described. In particular, recombinant adenovirus is used to diagnose a cancer in a patient and further used for screening compounds effective in treating the cancer in said patient.. ... Salk Institute For Biological Studies

Fibroblast growth factor (fgf) 1 mutants and methods of use to reduce blood glucose

The present disclosure provides fgf1 mutant proteins, which include an n-terminal deletion, point mutation(s), or combinations thereof. In some examples, the mutant fgf1 proteins have reduced mitogenic activity. ... Salk Institute For Biological Studies

Reprogramming progenitor compositions and methods of use therefore

The invention generally features compositions comprising induced pluripotent stem cell progenitors (also termed reprogramming progenitor cells) and methods of isolating such cells. The invention also provides compositions comprising induced pluripotent stem cells (ipscs) derived from such progenitor cells. ... Salk Institute For Biological Studies

Methods for treating metabolic disorders using fgf

The method provides methods and compositions for treating metabolic disorders such as impaired glucose tolerance, elevated blood glucose, insulin resistance, dyslipidemia, obesity, and fatty liver.. . ... Salk Institute For Biological Studies

01/18/18 / #20180015057

Err alpha and err gamma are essential coordinators of cardiac metabolism and function

Provided herein are methods and kits for increasing cardiac contraction, increasing mitochondrial activity, and/or increasing oxphos activity. Such methods include use of therapeutically effective amounts of one or more agents that increases estrogen-related receptor (err) α activity and one or more agents that increases errγ activity. ... Salk Institute For Biological Studies

01/04/18 / #20180000768

Intestinal fxr agonism enhances glp-1 signaling to restore pancreatic beta cell functions

Disclosed are embodiments of a method of treating or preventing latent autoimmune diabetes of adults (lada) in a subject. Such embodiments include administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or farnesoid x receptor (fxr) agonist compounds, thereby activating fxr receptors in the intestines, and treating or preventing latent autoimmune diabetes of adults (lada) in the subject.. ... Salk Institute For Biological Studies

12/14/17 / #20170355740

Methods of using fibroblast growth factor (fgf) 1 with mutation in the heparin binding domain and methods to reduce blood glucose

The present disclosure provides fgf1 mutant proteins having one or more mutations in the heparin binding domain. Such mutants may also have an n-terminal deletion, point mutation(s), or combinations thereof. ... Salk Institute For Biological Studies

10/26/17 / #20170305894

Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof

Provided herein are compounds of formula (i) and compositions useful in increasing ppars activity. The compounds and compositions provided herein are useful for the treatment of ppars related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).. ... Salk Institute For Biological Studies

10/26/17 / #20170304255

Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof

Provided herein are compounds of formula (i) useful for the treatment of ppar-delta related diseases (e.g. Mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases).. ... Salk Institute For Biological Studies

10/12/17 / #20170291931

Fgf2 truncations and mutants and uses thereof

The present disclosure provides fgf2 mutant proteins, such as those having an n-terminal deletion, point mutation(s), or combinations thereof, which can reduce blood glucose in a mammal. Thus, the disclosed mutant fgf2 proteins can be used to treat one or more metabolic diseases. ... Salk Institute For Biological Studies

10/05/17 / #20170283777

Mammalian chimeric complementation

Disclosed herein are chimeric mammals, such as a chimeric mammal comprising cells derived from at least a first mammal and a second mammal, wherein the cells from the first mammal comprise a genetic modification at one or more loci and the cells from the second mammal form at least one organ or tissue, wherein the first and second mammals are different species.. . ... Salk Institute For Biological Studies

08/31/17 / #20170246236

Methods and compositions for enhanced delivery of compounds

Disclosed are compositions and methods related to multivalent compositions targeted to cells and tissues. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.. ... Salk Institute For Biological Studies

08/10/17 / #20170226154

Ppar agonists and methods of use thereof

Provided herein are deuterated compounds and compositions useful in increasing pparδ activity. The compounds and compositions provided herein are useful for the treatment of pparδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).. ... Salk Institute For Biological Studies

07/20/17 / #20170205396

Systems and methods for culturing nephron progenitor cells

Provided herein are self-renewable nephron progenitor cell (srnpc) and methods for making and using.. . ... Salk Institute For Biological Studies

07/20/17 / #20170202893

Oncolytic tumor viruses and methods of use

Recombinant adenoviruses that selectively replicate in e2f deregulated tumor cells are described. The recombinant adenoviruses have a genome encoding a modified e1a protein, a modified or deleted e4orf1 protein, a modified or deleted e4orf6/7 protein, or any combination thereof, such that the recombinant adenoviruses exhibit replication defects in normal cells compared to tumor cells. ... Salk Institute For Biological Studies

07/13/17 / #20170196879

Use of inhibitor of apoptosis protein (iap) antagonists in hiv therapy

Provided herein is the use of compounds that modulate the activity of inhibitor of apoptosis proteins (1aps), alone or in combination with other therapeutic agents, in the treatment of human immunodeficiency virus (hiv). Described herein is the use of iap antagonists in the treatment of human immunodeficiency virus (hiv) in a mammal, alone or in combination with other therapeutic agents used in hiv therapy. ... Salk Institute For Biological Studies

07/06/17 / #20170189485

Modulation of estrogen receptor-related receptor gamma (err gamma) and uses therefor

This application provides methods of increasing vascularization, muscle performance, muscle rehabilitation, and/or mitochondrial activity in subjects in need thereof, by administering a therapeutically effective amount of one or more agents that increases errγ activity to the subject. Such agents can include one or more errγ agonists. ... Salk Institute For Biological Studies

06/08/17 / #20170157212

Cdk modulators and methods for the treatment of cancer

Disclosed is a polypeptide that includes amino acids 183-222 of crif, wherein the polypeptide does not include the full length crif1 amino acid sequence. Also disclosed is a nucleic acid molecule encoding this polypeptide, vectors including this nucleic acid molecule, and host cells transformed with these vectors. ... Salk Institute For Biological Studies

03/30/17 / #20170087189

Compositions and methods for treating type 1 and type 2 diabetes and related disorders

The invention features compositions comprising in vitro generated beta cells capable of glucose-stimulated insulin secretion, methods of inducing beta cell maturation from embryonic or induced pluripotent stem cell-derived beta-like cells, and methods of using in vitro generated beta cells for the treatment of type 1 diabetes, type 2 diabetes, or a related disorder.. . ... Salk Institute For Biological Studies

03/02/17 / #20170056475

Methods for treating metabolic disorders using fgf

The method provides methods and compositions for treating metabolic disorders such as impaired glucose tolerance, elevated blood glucose, insulin resistance, dyslipidemia, obesity, and fatty liver.. . ... Salk Institute For Biological Studies








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